No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
419 |
4. Check minimum number of eventsNone |
419 |
5. Include endpointsNone |
419 |
6. Filter based on genotype QC (FinnGen only) |
419 |
Control definitions (FinnGen only)
- Control exclude
- K11_APPENDIX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K35-K38
- Name in latin
- Alii morbi appendicis
Other diseases of appendix
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3360 | 2099 | 1235 |
| Only index persons | 2823 | 1812 | 1011 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.03 |
| Only index persons | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 37.74 | 37.44 | 37.89 |
| Only index persons | 33.98 | 34.08 | 33.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 419 | 286 | 133 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.06 |
| Median age at first event (years) | 37.42 | 35.73 | 41.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 377
- Matched controls
- 3772
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
54301
ICD-8 Finland
Other diseases of appendix, Stercolithium appendicis
+∞
74.5
69
*
K38.9
ICD-10 Finland
Disease of appendix, unspecified
+∞
73.4
68
*
JEA01
NOMESCO Finland
Laparoscopic appendectomy
76.7
57.4
64
10
K38.8
ICD-10 Finland
Other specified diseases of appendix
+∞
53.4
50
*
54309
ICD-8 Finland
Other diseases of appendix, Unspecified
+∞
52.3
49
*
54308
ICD-8 Finland
Other diseases of appendix, Alii definiti
+∞
41.4
39
*
5439X
ICD-9 Finland
Other diseases of appendix, Other and unspecified diseases of appendix
+∞
40.3
38
*
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
+∞
25.3
24
*
K38.1
ICD-10 Finland
Appendicular concretions
+∞
24.2
23
*
6421
FHL
Appendicectomy
9.2
19.0
40
48
54300
ICD-8 Finland
Other diseases of appendix, Mucocele appendicis
+∞
16.8
16
*
JEA00
NOMESCO Finland
Appendectomy
8.8
15.9
34
42
K35.1
ICD-10 Finland
Acute appendicitis with peritoneal abscess
+∞
13.6
13
*
54003
ICD-8 Finland
Acute appendicitis, Cum abscessu
+∞
12.6
12
*
D37.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Appendix
31.1
11.7
15
5
K38.0
ICD-10 Finland
Hyperplasia of appendix
+∞
11.5
11
*
D12.1
ICD-10 Finland
Benign neoplasm: Appendix
45.9
7.7
9
*
JAH01
NOMESCO Finland
Laparoscopy
4.2
7.6
28
71
K37
ICD-10 Finland
Unspecified appendicitis
81.6
7.4
8
*
C18.11
ICD-10 Finland
Malignant tumor of the appendix invasive carcinoma
30.6
7.2
9
*
N02AX02
ATC
tramadol; systemic, rectal
1.8
6.8
166
1146
54399
ICD-8 Finland
NA
+∞
6.3
6
*
K36
ICD-10 Finland
Other appendicitis
+∞
6.3
6
*
8480/3-C18.1
ICD-O-3
Mucinous adenocarcinoma of appendix
+∞
6.3
6
*
C18.19
ICD-10 Finland
Malignant tumor in appendix other or unspecified histology
27.2
6.2
8
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
81
372
2.46
10.88
4.0
4.0
3.8
20.7
ug/l
0.82
65
300
11
18
6.25
6.46
3.6
3.5
55.9
71.7
nmol/l
0.84
11
18
15
34
4.54
6.28
4.1
3.1
2.6
3.5
nmol/l
0.61
15
34
149
1080
1.59
4.69
2.6
2.5
65.9
57.2
u/l
0.26
137
997
45
235
2.02
4.36
1.4
1.6
—
—
—
0
0
227
1829
1.53
4.35
7.7
6.1
11.0
10.8
umol/l
0.11
220
1734
200
1583
1.50
4.08
4.9
3.9
—
—
—
0
0
14
42
3.41
4.08
1.4
1.5
—
—
—
0
0
30
141
2.21
3.81
3.9
2.8
788.2
1234.4
u/ml
0.14
24
117
40
212
1.98
3.73
2.4
2.4
26.5
68.9
u/ml
1.08
40
203
14
47
3.05
3.44
1.4
1.5
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
84
2.45
3.28
2.8
2.5
0.5
0.4
u/ml
—
9
49
235
1981
1.42
3.15
6.6
4.3
6.7
6.7
mmol/l
0.19
229
1856
235
1987
1.42
3.07
8.8
8.9
4.2
4.0
e9/l
0.70
214
1741
182
1474
1.41
3.02
5.7
4.4
36.4
35.7
g/l
0.88
168
1366
297
2624
1.45
3.00
4.3
4.1
12.2
12.1
mm/h
0.04
278
2406
261
2255
1.42
2.97
5.0
4.5
1699.0
3889.7
e6/l
—
7
40
49
303
1.70
2.84
2.1
2.0
375.8
365.3
nmol/l
0.13
44
282
304
2711
1.44
2.81
8.9
7.4
77.1
78.5
u/l
0.28
282
2537
12
42
2.91
2.77
1.3
1.6
—
—
—
0
0
109
816
1.45
2.75
2.8
2.2
—
—
—
0
0
22
107
2.11
2.62
1.9
1.9
38.6
37.7
g/l
0.23
17
93
162
1314
1.38
2.57
3.6
3.7
33.6
32.3
ng/l
0.04
111
911
14
58
2.46
2.39
1.4
1.6
—
—
—
0
0
21
105
2.05
2.35
1.9
1.6
—
200.0
—
0
7
44
280
1.64
2.31
1.8
2.5
66.3
67.1
g/l
0.23
38
257
187
1574
1.34
2.27
8.5
5.3
1.2
1.2
mmol/l
0.30
164
1431
23
121
1.95
2.25
1.9
2.0
3.4
3.2
g/l
0.33
18
97
201
1716
1.33
2.19
9.8
6.3
1.2
1.2
mmol/l
0.24
170
1457
8
24
3.38
2.19
1.9
1.3
—
—
—
0
0
6
14
4.33
2.16
1.7
1.4
—
—
—
0
0
198
1697
1.32
2.06
3.6
3.8
0.0
0.0
estimate
0.00
39
328
14
63
2.26
2.03
1.6
1.8
—
—
—
0
0
47
321
1.52
1.86
3.1
2.5
73.2
46.8
u/l
0.30
40
261
5
12
4.20
1.83
1.8
1.2
—
—
—
0
0
23
131
1.80
1.81
1.9
2.0
—
—
—
0
0
23
131
1.80
1.81
1.9
2.0
4.0
3.7
g/l
0.74
18
95
23
131
1.80
1.81
1.9
2.0
7.8
7.6
g/l
0.21
18
101
296
2707
1.32
1.81
4.3
4.0
14.9
14.7
pmol/l
0.43
269
2456
68
508
1.40
1.72
3.4
2.8
4.8
2.9
e6/l
0.42
37
262
5
13
3.88
1.72
1.8
1.2
—
—
—
0
0
196
1709
1.28
1.69
3.8
3.8
0.0
0.0
estimate
0.50
41
313
195
1704
1.27
1.64
5.2
5.1
0.0
0.0
estimate
0.00
40
330
22
128
1.76
1.64
1.7
2.1
—
—
—
0
0
72
549
1.38
1.62
3.2
2.6
1.1
1.0
e6/l
0.09
39
300
7
26
2.72
1.58
1.0
1.2
—
—
—
0
0
21
122
1.76
1.57
1.7
1.8
—
—
—
0
0
113
926
1.30
1.57
3.8
4.1
0.0
0.0
estimate
0.69
39
325
16
86
1.89
1.52
1.6
1.7
—
—
—
0
0
12
58
2.10
1.50
1.8
1.6
—
—
—
0
0
7
28
2.52
1.46
1.1
1.8
—
—
—
0
0
171
1489
1.25
1.44
2.6
2.2
77.3
78.1
nmol/l
0.13
154
1318
10
46
2.20
1.41
1.3
1.2
—
—
—
0
0
11
53
2.10
1.39
1.7
1.5
—
—
—
0
0
26
167
1.59
1.38
3.2
2.8
0.1
0.2
e6/l
1.02
26
162
16
90
1.81
1.35
1.6
1.7
—
—
—
0
0
55
415
1.37
1.34
29.1
21.2
1.5
1.3
inr
—
10
53
111
926
1.27
1.33
3.5
2.9
0.2
0.5
e6/l
2.07
84
691
256
2346
1.23
1.30
4.0
3.1
44.4
47.1
u/l
0.27
242
2189
342
3243
1.30
1.26
4.8
4.8
1.9
2.3
mu/l
0.56
315
2955
8
36
2.25
1.25
1.3
1.2
—
—
—
0
0
10
49
2.07
1.23
1.3
1.4
—
—
—
0
0
10
49
2.07
1.23
1.3
1.4
—
—
—
0
0
10
49
2.07
1.23
1.3
1.4
—
—
—
0
0
80
649
1.29
1.20
4.5
3.9
227.1
251.5
ng/l
0.06
57
504
10
50
2.02
1.17
1.3
1.4
—
—
—
0
0
10
50
2.02
1.17
1.3
1.4
—
—
—
0
0
10
50
2.02
1.17
1.3
1.4
—
—
—
0
0
28
191
1.50
1.17
1.5
1.7
—
—
—
0
0
8
39
2.07
1.16
1.9
1.6
—
—
—
0
0
29
201
1.48
1.13
1.2
1.4
—
—
—
0
0
91
756
1.26
1.13
1.2
1.2
2.8
1.8
u/ml
0.17
18
211
5
21
2.40
1.09
4.4
2.0
—
—
—
0
0
138
1207
1.21
1.06
3.6
3.1
—
—
—
0
0
12
67
1.81
1.05
3.7
3.7
58.2
56.8
%
0.09
12
67
15
90
1.69
1.05
1.1
1.3
—
—
—
0
0
67
541
1.28
1.05
1.9
1.9
—
—
—
0
0
348
3329
1.27
1.04
15.6
12.5
81.8
80.5
ml/min/173m2
0.55
310
2732
55
436
1.30
0.99
5.1
4.4
34.3
32.4
%
0.57
46
282
139
1225
1.20
0.98
3.9
3.4
2.4
2.4
mmol/l
0.23
117
1069
90
760
1.23
0.97
3.7
4.1
1.0
1.0
kg/l
0.09
13
100
10
54
1.87
0.97
1.0
1.3
—
—
—
0
0
362
3487
1.28
0.96
16.9
13.7
22.2
22.2
mg/l
0.00
307
2750
15
93
1.64
0.95
1.2
1.2
—
—
—
0
0
372
3600
1.30
0.91
19.6
15.5
139.7
139.7
mmol/l
0.10
367
3505
130
1148
1.19
0.89
3.4
3.1
33.4
31.9
u/l
0.19
124
1095
46
363
1.30
0.87
15.1
6.9
1.0
1.4
mmol/l
0.31
36
292
8
44
1.83
0.86
1.3
2.0
—
—
—
0
0
383
3727
1.32
0.84
12.0
10.4
26.8
25.6
u/l
0.66
371
3602
148
1329
1.18
0.83
4.0
3.9
—
—
—
0
0
122
1081
1.18
0.80
2.3
2.1
183.2
179.7
u/l
0.03
117
1019
76
645
1.22
0.80
1.7
1.7
1229.1
1196.0
nmol/l
0.13
56
474
11
66
1.68
0.79
3.4
3.2
4.9
4.4
e9/l
0.24
11
66
11
66
1.68
0.79
2.2
1.8
5249.6
734.5
u/l
—
5
21
11
66
1.68
0.79
2.6
4.2
28.8
25.9
mg/l
—
6
42
15
100
1.52
0.74
3.0
2.3
—
—
—
0
0
7
39
1.81
0.73
1.0
1.1
—
—
—
0
0
7
39
1.81
0.73
1.3
2.1
—
—
—
0
0
26
195
1.36
0.71
4.7
3.7
2.0
2.0
mmol/l
0.00
21
145
16
110
1.47
0.69
1.1
1.3
—
—
—
0
0
371
3611
1.24
0.69
19.6
15.6
4.0
4.0
mmol/l
0.12
366
3511
30
234
1.30
0.65
1.1
1.2
108.1
157.8
iu/ml
—
10
93
46
382
1.23
0.61
1.7
1.8
—
—
—
0
0
102
913
1.15
0.60
2.7
2.6
330.4
6204.9
umol/l
3.76
94
799
111
1003
1.15
0.57
2.6
3.0
1208.6
1112.6
ng/l
0.09
98
839
18
133
1.37
0.56
1.6
1.6
—
—
—
0
0
6
37
1.63
0.55
1.2
1.8
—
—
—
0
0
6
37
1.63
0.55
1.5
1.0
—
—
—
0
0
6
37
1.63
0.55
1.2
1.8
—
—
—
0
0
6
37
1.63
0.55
1.2
1.8
—
—
—
0
0
46
387
1.21
0.55
1.8
1.9
—
—
—
0
0
13
91
1.44
0.53
4.5
2.1
93.8
91.5
%
0.11
13
86
65
567
1.17
0.53
1.6
1.5
—
—
—
0
0
74
653
1.16
0.53
1.2
1.3
29.4
37.9
iu/ml
0.21
23
222
152
1409
1.12
0.52
2.1
1.9
105.8
96.1
pmol/l
1.18
80
690
9
63
1.44
0.52
1.4
1.4
—
—
—
0
0
89
803
1.14
0.47
1.6
1.5
21.1
22.2
nmol/l
0.25
74
678
7
48
1.47
0.47
1.4
1.1
—
—
—
0
0
74
662
1.14
0.45
3.1
2.8
2.4
2.5
mmol/l
1.43
66
577
159
1491
1.11
0.44
2.9
2.6
143.8
111.9
ug/l
0.45
145
1358
20
158
1.28
0.42
1.1
1.0
—
—
—
0
0
71
637
1.14
0.42
4.4
4.1
20.8
21.7
%
0.18
36
282
49
428
1.16
0.41
6.5
7.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
80
726
1.13
0.40
1.5
1.7
192308161.3
446.9
pmol/l
0.79
65
602
5
35
1.43
0.39
2.0
2.3
—
—
—
0
0
91
834
1.12
0.38
2.2
2.0
3.3
3.2
mg/l
0.04
78
703
10
72
1.40
0.37
1.1
1.1
102.2
3.1
e6/l
—
5
55
12
90
1.34
0.36
1.8
1.5
—
—
—
0
0
14
108
1.31
0.35
1.6
1.5
—
—
—
0
0
6
43
1.40
0.35
1.0
1.2
0.5
0.6
nmol/l
—
6
38
23
191
1.22
0.34
1.7
1.3
—
—
—
0
0
12
91
1.33
0.34
1.2
1.1
—
—
—
0
0
12
91
1.33
0.34
1.2
1.4
—
—
—
0
0
10
75
1.34
0.30
1.4
1.4
—
—
—
0
0
84
779
1.10
0.29
2.1
1.6
2.4
1.1
mg/l
0.48
63
602
62
566
1.11
0.29
1.3
1.4
—
—
—
0
0
11
85
1.30
0.28
1.5
1.4
—
—
—
0
0
340
3456
0.91
0.27
4.4
4.5
1.5
1.5
mmol/l
0.19
323
3190
13
105
1.25
0.25
1.7
1.6
—
—
—
0
0
53
485
1.11
0.25
3.0
2.2
2.3
2.3
g/l
0.03
47
443
332
3264
1.08
0.24
5.4
5.9
39.2
39.8
mmol/mol
0.77
302
3045
10
126
0.79
0.24
1.5
1.4
—
—
—
0
0
6
83
0.72
0.24
1.2
1.2
—
—
—
0
0
14
115
1.22
0.24
3.1
1.9
—
—
—
0
0
33
296
1.12
0.22
2.2
2.4
11.2
6.8
ug/l
0.59
27
261
343
3477
0.93
0.22
4.5
4.5
4.8
4.8
mmol/l
0.10
323
3233
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
1.2
1.4
—
—
—
0
0
32
288
1.12
0.20
6.4
3.4
1.8
2.4
mmol/l
0.49
27
230
6
50
1.20
0.20
2.7
1.7
—
—
—
0
0
346
3418
1.07
0.18
4.5
4.6
5.9
5.9
mmol/l
0.37
320
3117
7
58
1.21
0.18
1.4
1.7
231.1
231.4
pmol/l
—
7
52
10
83
1.21
0.15
1.2
1.8
—
—
—
0
0
32
294
1.10
0.15
6.5
3.4
5.6
5.8
kpa
0.73
32
287
9
82
1.10
0.15
1.9
1.5
—
—
—
0
0
45
421
1.08
0.14
9.4
5.2
1.0
1.0
mmol/l
0.68
40
389
9
83
1.09
0.14
1.2
1.2
—
—
—
0
0
27
248
1.09
0.13
6.1
2.7
4.4
4.4
kpa
0.08
27
240
31
287
1.09
0.13
2.5
2.8
66.5
65.5
ml/min/173m2
0.05
11
122
37
346
1.08
0.12
3.1
3.3
—
—
—
0
0
13
114
1.14
0.12
1.6
1.9
—
—
—
0
0
94
972
0.96
0.11
1.8
1.6
1.3
1.4
mmol/l
0.23
86
823
352
3547
0.95
0.11
4.9
5.0
2.8
2.8
mmol/l
0.20
333
3266
314
3169
0.96
0.10
18.4
14.4
39.7
40.0
%
0.30
224
2296
5
44
1.14
0.10
1.4
1.4
—
—
—
0
0
5
44
1.14
0.10
1.4
1.4
—
—
—
0
0
5
44
1.14
0.10
1.4
1.4
—
—
—
0
0
5
63
0.79
0.08
1.0
1.3
—
—
—
0
0
5
63
0.79
0.08
1.0
1.3
—
—
—
0
0
31
293
1.06
0.08
1.7
1.9
—
—
—
0
0
54
521
1.04
0.07
3.1
2.3
12.9
13.3
umol/l
0.12
49
477
218
2155
1.02
0.07
2.9
2.9
—
—
—
0
0
33
315
1.05
0.06
2.0
1.7
—
—
—
0
0
14
152
0.92
0.06
1.6
2.3
35.5
38.1
u/l
0.20
14
136
49
479
1.03
0.03
3.5
2.9
0.8
0.7
ug/l
0.20
33
294
11
118
0.93
0.03
1.4
1.1
—
—
—
0
0
11
118
0.93
0.03
1.3
1.1
—
—
—
0
0
334
3350
0.99
0.02
4.0
4.0
1.3
1.3
mmol/l
0.10
316
3068
46
453
1.02
0.01
3.3
2.3
21.3
22.7
%
0.22
38
390
26
261
1.00
0.00
1.5
1.8
—
—
—
0
0
10
95
1.05
0.00
1.5
1.3
—
—
—
0
0
62
617
1.01
0.00
1.3
1.3
4.0
10.8
u/ml
1.25
19
237
80
796
1.01
0.00
5.2
4.7
2.9
2.5
ug/l
0.23
73
716
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
60.3
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
22.6
—
0
8
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
0.00
1.6
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
119.2
—
0
6
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
168.5
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
65.7
—
0
6
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
6
60
1.00
0.00
1.7
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
90.7
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint K11_OTHAPPEND and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_OTHAPPEND | 1.183 [0.87, 1.6] | 0.277 |
| Birth year | 0.996 [0.99, 1.0] | 0.385 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 525 females with K11_OTHAPPEND died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_OTHAPPEND | 1.303 [0.91, 1.86] | 0.142 |
| Birth year | 0.989 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 371 males with K11_OTHAPPEND died.
Mortality risk
Mortality risk for people of age
years, who have K11_OTHAPPEND.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.251% |
| 5 | 0.711% | 1.634% |
| 10 | 1.591% | 4.017% |
| 15 | 3.205% | 7.607% |
| 20 | 6.275% | 13.089% |
Relationships between endpoints
↥Index endpoint: K11_OTHAPPEND – Other diseases of appendix
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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