No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
384 |
4. Check minimum number of eventsNone |
384 |
5. Include endpointsNone |
384 |
6. Filter based on genotype QC (FinnGen only) |
371 |
Control definitions (FinnGen only)
- Control exclude
- K11_OESSTODUO
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K20-K31
- Name in latin
- Ulcus pepticum loco non specificato
Similar endpoints
↥List of similar endpoints to
Peptic ulcer
based on the number of shared cases.
Similar with more cases:
- Gastroduodenal ulcer
- Diseases of oesophagus, stomach and duodenum
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4182 | 1927 | 2191 |
| Only index persons | 3048 | 1448 | 1600 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 63.74 | 68.52 | 59.49 |
| Only index persons | 61.57 | 66.17 | 57.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 371 | 175 | 196 |
| Unadjusted period prevalence (%) | 0.08 | 0.06 | 0.09 |
| Median age at first event (years) | 60.25 | 56.63 | 63.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 384
- Matched controls
- 3839
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
16.0
174.8
246
385
K27.9
ICD-10 Finland
Peptic ulcer, site unspecified, unspecified as acute or chronic, without haemorrhage or perforation
+∞
146.5
131
*
K27.0
ICD-10 Finland
Peptic ulcer, site unspecified, acute with haemorrhage
+∞
109.8
100
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
26.6
71.8
51
22
UJD02
NOMESCO Finland
Gastroscopy
16.5
54.6
48
33
K92.1
ICD-10 Finland
Melaena
9.5
49.8
64
79
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
12.6
40.2
41
36
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.9
38.0
193
793
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
7.6
33.5
51
76
K25.9
ICD-10 Finland
Gastric ulcer, Unspecified as acute or chronic, without haemorrhage or perforation
+∞
31.7
30
*
K27.1
ICD-10 Finland
Peptic ulcer, site unspecified, acute with perforation
+∞
29.6
28
*
K27.4
ICD-10 Finland
Peptic ulcer, site unspecified, chronic or unspecified with haemorrhage
+∞
26.3
25
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.6
26.1
70
177
K27.3
ICD-10 Finland
Peptic ulcer, site unspecified, acute without haemorrhage or perforation
+∞
25.3
24
*
K25.4
ICD-10 Finland
Gastric ulcer, Chronic or unspecified with haemorrhage
+∞
24.2
23
*
K25.0
ICD-10 Finland
Gastric ulcer, Acute with haemorrhage
+∞
23.2
22
*
A02BC03
ATC
lansoprazole; oral
3.0
22.3
143
636
A02BC01
ATC
omeprazole; systemic
3.0
22.3
142
630
53399
ICD-8 Finland
Peptic ulcer, site unspecified, Without mention of perforation
+∞
21.0
20
*
A02BC02
ATC
pantoprazole; systemic
3.0
20.8
284
1855
D64.9
ICD-10 Finland
Anaemia, unspecified
3.8
20.6
71
215
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.3
20.3
91
327
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
7.7
19.3
28
39
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
7.2
18.9
29
43
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.5
18.6
49
121
K29.7
ICD-10 Finland
Gastritis, unspecified
28.3
18.0
24
9
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
17.7
74
253
K30
ICD-10 Finland
Functional dyspepsia
4.7
17.1
42
98
K25.3
ICD-10 Finland
Gastric ulcer, Acute without haemorrhage or perforation
177.3
16.6
17
*
K29.3
ICD-10 Finland
Chronic superficial gastritis
42.1
16.5
20
5
UJF32
NOMESCO Finland
Coloscopy
2.7
16.4
122
573
JN3AD
NOMESCO Finland
Abdominal CT examination
3.4
15.7
63
209
E66.8
ICD-10 Finland
Other obesity
6.0
14.8
27
48
K27.7
ICD-10 Finland
Peptic ulcer, site unspecified, chronic without haemorrhage or perforation
+∞
13.6
13
*
A02BA02
ATC
ranitidine; systemic
2.6
13.4
94
424
R10.0
ICD-10 Finland
Acute abdomen
6.6
13.4
22
35
K92.0
ICD-10 Finland
Haematemesis
12.8
13.3
23
19
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
29.5
13.1
17
6
A02BD03
ATC
lansoprazole, amoxicillin and metronidazole; systemic
4.0
12.6
37
99
K25.1
ICD-10 Finland
Gastric ulcer, Acute with perforation
+∞
12.6
12
*
JDA60
NOMESCO Finland
Closure of perforated ulcer of stomach
+∞
12.6
12
*
K27.5
ICD-10 Finland
Peptic ulcer, site unspecified, chronic or unspecified with perforation
+∞
12.6
12
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
12.3
82
360
R11
ICD-10 Finland
Nausea and vomiting
3.3
12.1
48
158
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
11.7
100
492
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
19.7
11.7
17
9
K26.0
ICD-10 Finland
Duodenal ulcer, acute with haemorrhage
+∞
11.5
11
*
K25.7
ICD-10 Finland
Gastric ulcer, Chronic without haemorrhage or perforation
+∞
11.5
11
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.6
11.4
28
65
C03CA01
ATC
furosemide; systemic
2.1
11.2
157
945
N02AX02
ATC
tramadol; systemic, rectal
2.1
10.8
178
1133
K26.9
ICD-10 Finland
Duodenal ulcer, unspecified as acute or chronic, without haemorrhage or perforation
+∞
10.5
10
*
A02BC05
ATC
esomeprazole; systemic
2.1
10.5
150
905
R50.9
ICD-10 Finland
Fever, unspecified
2.6
10.4
70
307
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
19.4
10.3
15
8
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
10.2
127
725
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.9
10.2
53
204
JAH00
NOMESCO Finland
Laparotomy
5.1
9.9
21
43
P01AB01
ATC
metronidazole; oral, rectal
2.0
9.7
156
975
K26.4
ICD-10 Finland
Duodenal ulcer, chronic or unspecified with haemorrhage
+∞
9.4
9
*
K26.3
ICD-10 Finland
Duodenal ulcer, acute without haemorrhage or perforation
+∞
9.4
9
*
53390
ICD-8 Finland
Peptic ulcer, site unspecified, Perforatione non indicata, cum haemorrhagia
+∞
9.4
9
*
N05BA01
ATC
diazepam; systemic, rectal
2.5
9.1
61
266
A06AD11
ATC
lactulose; oral
2.3
8.8
76
373
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.3
8.6
33
106
R07.3
ICD-10 Finland
Other chest pain
2.8
8.5
46
180
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
8.5
40
145
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
20.6
8.5
12
6
A03FA02
ATC
cisapride; oral, rectal
3.0
8.5
38
134
E66.01
ICD-10 Finland
Obesity due to excess calories
3.1
8.5
36
123
K29.9
ICD-10 Finland
Gastroduodenitis, unspecified
92.0
8.4
9
*
K27.2
ICD-10 Finland
Peptic ulcer, site unspecified, acute with both haemorrhage and perforation
+∞
8.4
8
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.0
8.2
110
638
J01FF01
ATC
clindamycin; systemic
2.0
8.1
106
610
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.6
8.0
50
211
N03AX16
ATC
[U] pregabalin
2.1
8.0
93
512
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.6
8.0
26
75
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.2
7.7
78
406
ZXD05
NOMESCO Finland
Urgent procedure
1.9
7.5
120
736
JDA32
NOMESCO Finland
Endoscopic injection in stomach or pylorus
81.6
7.4
8
*
K29.0
ICD-10 Finland
Acute haemorrhagic gastritis
+∞
7.3
7
*
JDA61
NOMESCO Finland
Laparoscopic closure of perforated ulcer of stomach
+∞
7.3
7
*
K22.6
ICD-10 Finland
Gastro-oesophageal laceration-haemorrhage syndrome
+∞
7.3
7
*
K29.4
ICD-10 Finland
Chronic atrophic gastritis
30.6
7.2
9
*
UJF92
NOMESCO Finland
Capsular endoscopy
8.2
7.2
15
19
L04AX01
ATC
azathioprine; systemic
4.2
7.2
19
47
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
7.1
51
229
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
7.1
175
1224
N05CF01
ATC
zopiclone; oral
1.8
7.1
137
891
JKA20
NOMESCO Finland
Cholecystectomy
4.3
7.1
18
43
C07AB07
ATC
bisoprolol; oral
1.8
7.1
197
1428
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.1
7.1
77
412
J01MA12
ATC
levofloxacin; systemic
2.0
7.0
81
443
R52.2
ICD-10 Finland
Other chronic pain
3.9
6.9
20
53
J01MA02
ATC
ciprofloxacin; systemic
1.8
6.9
155
1054
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
6.9
109
665
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
3.8
6.8
21
58
A07AA09
ATC
vancomycin; oral
11.2
6.8
12
11
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
4.0
6.8
19
49
SPAT1262
SPAT
Handing over of treatment supplies
2.1
6.7
73
391
K65.0
ICD-10 Finland
Acute peritonitis
10.3
6.6
12
12
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
6.5
78
431
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.3
6.5
24
75
E86
ICD-10 Finland
Volume depletion
5.9
6.5
17
30
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.3
6.5
52
246
K27
ICD-10 Finland
Peptic ulcer, site unspecified
71.0
6.4
7
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.2
6.4
17
42
A02BA04
ATC
nizatidine; systemic
2.7
6.4
35
138
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
+∞
6.3
6
*
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
27.1
6.2
8
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.3
6.2
48
223
C10AC01
ATC
colestyramine; oral
5.9
6.2
16
28
AA1AD
NOMESCO Finland
CT of head and brain
1.8
6.2
106
660
E66.00
ICD-10 Finland
Metabolic syndrome
3.2
6.2
25
83
205
Kela drug reimbursment
Chronic hypertension
1.8
6.2
117
752
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
6.1
54
266
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.4
6.1
22
68
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.1
6.1
25
84
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
186
852
3.29
29.01
3.7
2.3
52.11
62.18
u/l
1.04
173
779
228
1478
2.33
14.53
9.4
6.1
12.03
11.45
umol/l
0.21
216
1399
136
710
2.42
14.32
3.6
2.0
3.43
3.25
mg/l
0.34
125
601
56
189
3.30
13.55
1.9
1.6
—
—
—
0
0
92
433
2.48
11.90
3.3
2.3
11.40
12.59
umol/l
0.81
86
399
81
374
2.48
10.84
3.4
2.4
21.12
22.39
%
0.26
71
328
107
561
2.26
10.72
1.9
1.7
1204.34
1221.28
nmol/l
0.05
86
408
96
484
2.31
10.53
2.3
1.8
—
—
—
0
0
73
326
2.53
10.47
2.3
1.7
—
—
—
0
0
177
1140
2.02
10.26
4.9
3.7
36.17
49.01
ng/l
0.76
135
835
183
1225
1.94
9.20
8.1
4.3
33.18
35.29
g/l
4.63
176
1140
20
43
4.85
8.92
4.2
3.2
43.85
33.97
umol/l
1.01
20
37
191
1308
1.91
8.87
3.9
2.5
—
—
—
0
0
19
40
4.94
8.68
1.3
1.5
—
—
—
0
0
203
1427
1.90
8.62
20.6
15.1
1.29
1.30
inr
0.03
60
419
111
637
2.04
8.59
3.5
2.6
5.20
4.81
e6/l
0.19
103
573
54
229
2.58
8.55
9.5
7.4
11.24
10.31
mmol/l
0.43
54
217
162
1063
1.91
8.47
4.0
3.1
—
—
—
0
0
85
449
2.15
8.15
2.0
1.8
31.34
29.08
s
2.34
85
437
69
335
2.29
8.13
2.3
1.7
—
—
—
0
0
168
1136
1.85
7.84
5.0
2.6
142.43
143.09
ug/l
0.01
162
1036
63
301
2.31
7.69
3.2
2.7
9.80
8.46
umol/l
0.21
56
268
20
49
4.25
7.63
1.3
1.5
—
—
—
0
0
57
265
2.35
7.39
5.7
3.5
1.10
2.12
mmol/l
1.11
47
215
57
267
2.33
7.27
5.7
3.5
5.78
5.81
kpa
0.06
57
259
25
75
3.49
7.23
1.3
1.3
—
—
—
0
0
131
844
1.84
6.97
2.2
2.0
259.05
252.38
u/l
0.03
124
798
215
1606
1.77
6.90
11.6
8.8
4.59
4.14
e9/l
1.58
201
1418
17
41
4.29
6.61
1.3
1.5
—
—
—
0
0
50
231
2.34
6.57
4.8
2.6
4.39
4.36
kpa
0.04
50
222
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
86
3.17
6.47
2.4
2.1
0.28
0.38
u/ml
0.62
17
38
272
2204
1.80
6.33
12.3
7.1
89.47
77.67
u/l
2.60
262
2052
221
1691
1.72
6.28
6.6
4.4
7.24
6.73
mmol/l
2.10
215
1589
20
57
3.65
6.24
1.5
1.4
260.62
273.10
ug/g
0.07
11
26
90
532
1.90
6.19
1.4
1.2
5.81
1.46
u/ml
0.77
35
142
240
1884
1.73
6.16
6.7
4.4
47.00
2330.26
e6/l
—
9
38
62
323
2.10
6.08
7.2
6.5
0.43
1.41
mmol/l
0.99
53
259
126
833
1.76
6.00
3.8
3.1
0.50
0.41
e6/l
0.25
106
632
39
168
2.47
5.97
4.0
4.0
1.19
2.14
mmol/l
0.68
29
122
24
81
3.09
5.79
2.0
1.5
—
—
—
0
0
192
1441
1.66
5.64
9.8
6.2
1.21
1.22
mmol/l
0.68
165
1213
160
1149
1.67
5.55
2.7
1.9
85.88
94.54
pmol/l
1.91
106
581
106
689
1.74
5.26
1.9
1.6
19.70
20.64
nmol/l
0.28
97
578
45
224
2.14
4.95
3.3
2.8
269.71
240.65
ng/l
0.11
38
205
20
67
3.09
4.90
1.2
1.6
—
—
—
0
0
223
1777
1.61
4.88
4.3
2.8
76.98
49.41
u/l
2.29
209
1652
20
69
3.00
4.67
1.3
1.5
—
—
—
0
0
127
891
1.64
4.66
4.2
3.7
7.39
11.74
mg/mmol
0.57
89
544
37
175
2.23
4.61
1.8
1.4
—
—
—
0
0
15
36
4.29
4.56
1.3
1.6
—
—
—
0
0
15
44
3.51
4.51
1.3
1.3
—
—
—
0
0
22
82
2.78
4.50
1.5
1.6
—
—
—
0
0
174
1327
1.57
4.46
9.0
5.4
1.20
1.22
mmol/l
1.13
167
1183
89
576
1.71
4.42
2.3
1.6
1.50
1.20
mg/l
0.44
76
449
36
178
2.13
4.04
5.1
3.0
121.39
126.85
g/l
0.69
36
173
124
895
1.57
3.94
4.0
3.0
7.42
7.47
mmol/l
0.04
105
748
96
661
1.60
3.70
4.2
2.3
—
—
—
0
0
174
1369
1.49
3.65
5.5
3.7
0.00
0.00
estimate
-0.00
46
290
174
1372
1.49
3.59
7.4
4.9
0.00
0.00
estimate
-0.00
41
263
91
626
1.59
3.51
2.0
1.7
100000380.36
444.52
pmol/l
0.49
73
511
175
1387
1.48
3.50
5.4
3.7
0.00
0.00
estimate
-0.00
41
256
16
59
2.79
3.36
1.6
1.4
—
—
—
0
0
121
896
1.51
3.35
3.3
3.1
2133.67
1583.22
ng/l
0.53
106
769
13
43
3.09
3.28
1.3
1.2
—
—
—
0
0
12
34
3.61
3.22
1.6
1.2
—
—
—
0
0
14
49
2.93
3.22
1.3
1.5
—
—
—
0
0
14
49
2.93
3.22
1.3
1.5
—
—
—
0
0
127
957
1.49
3.21
4.1
3.3
2.33
2.36
mmol/l
0.94
107
848
39
217
1.89
3.19
5.3
3.8
87.69
87.25
ng/l
0.01
33
188
15
55
2.80
3.19
1.2
1.5
—
—
—
0
0
16
61
2.69
3.17
1.7
1.3
—
—
—
0
0
140
1079
1.47
3.15
6.0
3.9
—
—
—
0
0
82
566
1.57
3.10
4.5
3.5
651.91
236.56
ng/l
0.32
63
449
99
716
1.52
3.03
3.4
2.8
3944.32
7807.24
umol/l
0.45
82
622
14
51
2.81
3.01
1.0
1.3
—
—
—
0
0
10
26
3.92
3.00
1.9
2.5
—
—
—
0
0
106
781
1.49
2.96
5.5
3.9
0.00
0.00
estimate
-0.00
40
259
21
96
2.26
2.89
2.1
2.4
—
—
—
0
0
49
304
1.70
2.82
3.4
4.2
3.35
21.37
ug/l
0.71
44
253
8
18
4.51
2.81
1.5
1.5
—
—
—
0
0
11
34
3.30
2.74
1.1
1.4
—
—
—
0
0
11
34
3.30
2.74
1.3
1.7
—
—
—
0
0
11
34
3.30
2.74
1.1
1.4
—
—
—
0
0
7
14
5.07
2.74
1.0
1.4
—
—
—
0
0
15
60
2.56
2.73
2.3
2.4
14.49
15.53
%
—
9
29
11
35
3.20
2.66
1.4
1.5
—
—
—
0
0
11
35
3.20
2.66
1.4
1.5
—
—
—
0
0
14
55
2.60
2.64
2.8
1.7
4415.60
357.43
u/l
—
5
10
11
36
3.11
2.58
1.4
1.5
—
—
—
0
0
11
36
3.11
2.58
1.4
1.5
—
—
—
0
0
11
36
3.11
2.58
1.3
1.7
—
—
—
0
0
11
36
3.11
2.58
1.4
1.5
—
—
—
0
0
12
42
2.92
2.57
1.3
1.2
573.80
291.46
u/ml
—
5
28
12
44
2.78
2.57
1.1
1.4
—
—
—
0
0
8
21
3.87
2.47
1.0
1.1
—
—
—
0
0
9
29
3.15
2.24
1.6
1.3
—
—
—
0
0
10
35
2.90
2.22
1.4
1.5
—
—
—
0
0
5
9
5.61
2.22
1.0
2.9
113.20
89.89
%
—
5
9
48
318
1.58
2.17
4.5
3.4
—
—
—
0
0
69
496
1.48
2.15
3.3
2.8
1.08
1.02
e6/l
0.05
44
294
13
55
2.41
2.14
1.4
1.3
—
—
—
0
0
13
55
2.41
2.14
1.4
1.3
—
—
—
0
0
12
50
2.44
2.04
2.6
2.8
5.90
4.49
e9/l
0.57
12
50
5
11
4.59
1.94
3.2
1.5
18.40
31.27
umol/l
—
5
11
81
613
1.41
1.92
6.4
4.1
1.02
1.02
kg/l
0.57
18
82
9
34
2.68
1.87
1.1
1.4
—
—
—
0
0
12
53
2.30
1.82
2.7
3.2
62.83
57.42
%
0.57
12
53
29
177
1.69
1.82
2.6
1.7
—
—
—
0
0
8
29
2.79
1.80
1.5
1.7
—
—
—
0
0
8
29
2.79
1.80
1.5
1.7
—
—
—
0
0
8
29
2.79
1.80
1.5
1.7
—
—
—
0
0
134
1112
1.31
1.75
3.2
2.1
72.71
77.91
nmol/l
1.28
123
981
27
164
1.69
1.73
5.1
2.9
0.60
0.22
e6/l
0.69
27
159
16
82
1.99
1.72
1.6
2.6
31.03
90.97
ug/min
—
9
50
236
2116
1.30
1.70
5.3
3.8
16.44
12.83
mm/h
2.34
220
1916
23
135
1.75
1.66
1.3
1.1
98.78
157.72
iu/ml
—
10
50
21
120
1.79
1.65
1.0
1.0
—
—
—
0
0
62
461
1.41
1.63
3.3
2.9
1.22
1.53
e6/l
0.31
37
259
5
14
3.60
1.62
1.4
1.5
—
—
—
0
0
5
14
3.60
1.62
1.0
1.4
—
—
—
0
0
10
207
0.47
1.60
1.6
1.7
—
—
—
0
0
6
20
3.03
1.58
1.2
1.5
—
—
—
0
0
5
15
3.36
1.52
1.4
1.5
—
—
—
0
0
5
15
3.36
1.52
1.0
1.1
—
—
—
0
0
9
40
2.28
1.41
1.2
1.1
—
—
—
0
0
7
29
2.44
1.40
1.0
1.3
—
—
—
0
0
15
82
1.86
1.37
1.8
1.3
—
—
—
0
0
19
113
1.72
1.34
2.7
1.7
—
—
—
0
0
14
76
1.87
1.31
1.2
1.2
—
—
—
0
0
14
76
1.87
1.31
1.2
1.2
—
—
—
0
0
39
280
1.44
1.26
2.4
2.0
1.62
1.46
%
0.57
32
247
5
19
2.65
1.22
1.2
1.6
66.40
84.84
umol/l
—
5
19
70
559
1.31
1.19
4.2
3.0
2.45
2.46
mmol/l
0.17
58
507
6
26
2.33
1.19
2.2
2.0
—
—
—
0
0
13
73
1.81
1.12
2.3
1.5
—
—
—
0
0
7
34
2.08
1.03
1.1
1.1
—
—
—
0
0
30
216
1.42
0.99
5.2
2.5
64.50
63.50
ml/min/173m2
0.03
12
86
5
23
2.19
0.98
2.0
1.1
—
—
—
0
0
181
1640
1.20
0.97
3.3
2.7
—
—
—
0
0
10
55
1.84
0.93
1.9
1.3
—
—
—
0
0
6
29
2.08
0.89
1.8
1.3
31.77
19.99
u/l
—
6
22
52
417
1.29
0.88
1.5
1.5
—
—
—
0
0
19
129
1.50
0.85
1.4
1.3
—
—
—
0
0
225
2095
1.18
0.84
4.4
3.7
14.95
14.93
pmol/l
0.04
208
1868
6
32
1.89
0.82
4.2
4.5
—
—
—
0
0
18
122
1.50
0.81
1.8
1.8
—
—
—
0
0
6
33
1.83
0.79
1.3
1.2
—
—
—
0
0
11
67
1.66
0.76
1.2
1.2
—
—
—
0
0
5
24
2.10
0.74
1.2
1.1
—
—
—
0
0
9
56
1.62
0.73
2.0
1.4
—
—
—
0
0
10
60
1.68
0.72
1.5
1.1
—
—
—
0
0
5
28
1.80
0.66
2.2
1.9
—
—
—
0
0
298
2865
1.18
0.65
31.2
14.0
28.82
24.86
mg/l
1.22
268
2249
7
44
1.60
0.65
1.0
1.0
—
—
—
0
0
8
50
1.61
0.61
1.9
2.0
—
—
—
0
0
50
420
1.22
0.60
1.2
1.3
1.51
13.61
u/ml
3.04
19
175
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
10
65
1.55
0.56
1.2
1.1
—
13.10
—
0
8
16
116
1.40
0.55
1.7
1.6
—
—
—
0
0
77
859
0.87
0.49
4.8
4.3
19.15
21.81
%
1.02
37
426
7
47
1.50
0.48
1.7
1.4
—
—
—
0
0
310
3176
0.87
0.44
43.8
20.6
38.09
40.06
%
6.29
294
2962
279
2876
0.89
0.44
5.6
4.9
2.53
2.69
mmol/l
2.13
264
2611
5
32
1.57
0.42
1.4
1.0
—
—
—
0
0
5
32
1.57
0.42
1.4
1.2
—
—
—
0
0
5
33
1.52
0.41
1.6
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
99
1073
0.90
0.40
6.2
4.9
3.02
2.93
ug/l
0.05
89
950
273
2811
0.90
0.39
5.2
4.4
4.43
4.59
mmol/l
1.82
259
2561
0
19
0.00
0.39
0.0
1.1
—
1.14
—
0
13
271
2789
0.90
0.38
5.2
4.4
1.37
1.46
mmol/l
2.63
255
2529
9
69
1.31
0.37
1.1
1.2
—
—
—
0
0
56
622
0.88
0.34
2.8
2.9
0.63
0.82
ug/l
1.35
43
404
12
91
1.33
0.34
1.5
2.2
—
—
—
0
0
19
155
1.24
0.33
1.2
1.4
—
51.44
—
0
14
272
2784
0.92
0.28
5.3
4.5
6.27
6.02
mmol/l
1.74
254
2500
5
40
1.25
0.22
1.6
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
6.3
—
—
—
0
0
266
2711
0.94
0.21
25.9
13.6
79.36
78.62
ml/min/173m2
0.19
238
2235
0
14
0.00
0.20
0.0
3.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
3.6
—
—
—
0
0
272
2669
1.06
0.20
7.4
5.8
41.87
40.19
mmol/mol
1.57
256
2450
49
456
1.09
0.17
1.2
1.3
49.40
39.98
iu/ml
0.16
15
151
15
129
1.17
0.17
2.2
3.3
4.56
4.38
pmol/l
0.31
15
115
264
2594
1.06
0.17
5.3
4.4
1.82
1.95
mu/l
1.08
246
2323
8
71
1.13
0.16
1.0
1.3
—
—
—
0
0
73
757
0.96
0.10
1.9
1.7
1.68
1.34
mmol/l
1.65
63
627
5
47
1.06
0.09
4.0
1.5
—
—
—
0
0
19
175
1.09
0.08
2.5
2.6
—
8.85
—
0
11
303
3049
0.97
0.06
16.7
10.0
26.09
25.53
u/l
0.23
298
2920
33
345
0.95
0.06
1.5
1.4
—
—
—
0
0
268
2697
0.98
0.05
4.7
3.9
1.38
1.27
mmol/l
1.57
253
2433
38
373
1.02
0.01
12.4
7.3
—
—
—
0
0
12
114
1.05
0.00
1.8
2.2
—
—
—
0
0
10
95
1.05
0.00
1.6
1.6
—
—
—
0
0
24
237
1.01
0.00
1.5
2.3
—
—
—
0
0
22
221
0.99
0.00
1.6
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
5
59
0.85
-0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
16.19
—
0
7
0
9
0.00
-0.00
0.0
1.3
—
9.91
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
7.21
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
7
70
1.00
-0.00
1.6
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_PULC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PULC | 1.855 [1.57, 2.19] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.207 |
During the follow-up period (1.1.1998 — 31.12.2019), 586 out of 1363 females with K11_PULC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PULC | 2.396 [1.99, 2.88] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 608 out of 1406 males with K11_PULC died.
Mortality risk
Mortality risk for people of age
years, who have K11_PULC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.215% | 0.419% |
| 5 | 1.024% | 2.613% |
| 10 | 2.649% | 6.388% |
| 15 | 4.898% | 11.583% |
| 20 | 8.644% | 19.041% |
Relationships between endpoints
↥Index endpoint: K11_PULC – Peptic ulcer
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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