diffuse idiopathic skeletal hyperostosis: This syndrome is characterized by the association of ankylosing vertebral hyperostosis with hyperkeratosis of the soles and palms.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
495 |
4. Check minimum number of eventsNone |
495 |
5. Include endpointsNone |
495 |
6. Filter based on genotype QC (FinnGen only) |
477 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M48
- Name in latin
- Hyperostosis ancylopoetica
Similar endpoints
↥List of similar endpoints to
Ankylosing hyperostosis [Forestier]
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3079 | 1249 | 1805 |
| Only index persons | 2836 | 1179 | 1657 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.05 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 58.00 | 58.94 | 57.26 |
| Only index persons | 57.53 | 58.39 | 56.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 477 | 191 | 286 |
| Unadjusted period prevalence (%) | 0.11 | 0.07 | 0.13 |
| Median age at first event (years) | 58.25 | 57.40 | 58.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 495
- Matched controls
- 4950
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M48.1
ICD-10 Finland
Ankylosing hyperostosis [Forestier]
+∞
307.7
483
*
M48.0
ICD-10 Finland
Spinal stenosis
134.8
307.7
175
20
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
60.1
236.6
136
31
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
47.0
148.4
89
23
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
26.9
136.2
98
45
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
10.4
116.9
156
209
M54.6
ICD-10 Finland
Pain in thoracic spine
17.1
116.1
104
76
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
16.0
113.8
106
83
N03AX12
ATC
[U] gabapentin; oral
9.3
109.7
163
248
M47.82
ICD-10 Finland
Other spondylosis, cervical region
51.4
101.3
59
13
N03AX16
ATC
[U] pregabalin
7.2
97.6
200
427
M54.5
ICD-10 Finland
Low back pain
6.5
96.4
252
678
M54.4
ICD-10 Finland
Lumbago with sciatica
8.7
86.2
127
188
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
252.1
84.2
84
*
M54.9
ICD-10 Finland
Dorsalgia, unspecified
10.0
79.0
100
122
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
27.0
72.8
51
21
N02AX02
ATC
tramadol; systemic, rectal
4.9
67.7
308
1236
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
128.8
63.6
67
6
M43.1
ICD-10 Finland
Spondylolisthesis
29.7
60.8
41
15
L03
ICPC
Low back symptom/complaint
4.6
53.4
171
509
M47.9
ICD-10 Finland
Spondylosis, unspecified
201.5
53.1
54
*
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
18.3
51.1
42
25
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
75.5
48.2
54
8
N06AX21
ATC
duloxetine; oral
6.4
47.5
88
162
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.7
45.6
290
1362
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
12.6
42.6
43
37
M53.1
ICD-10 Finland
Cervicobrachial syndrome
6.7
42.5
73
124
L86
ICPC
Back syndrome with radiating pain
8.8
42.2
56
71
M45
ICD-10 Finland
Ankylosing spondylitis
211.2
38.4
39
*
L02
ICPC
Back symptom/complaint
5.4
37.0
82
177
M54.8
ICD-10 Finland
Other dorsalgia
11.7
35.0
37
34
M03BX02
ATC
tizanidine; oral
3.4
34.7
343
1991
M01AH05
ATC
etoricoxib; oral
3.4
34.3
357
2130
M54.3
ICD-10 Finland
Sciatica
9.4
33.2
41
47
E66.01
ICD-10 Finland
Obesity due to excess calories
5.2
32.4
73
159
N06AA09
ATC
amitriptyline; systemic
5.2
30.9
70
153
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
62.6
30.5
35
6
N02BF01
ATC
gabapentin; oral
6.1
30.5
56
101
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
3.1
30.0
188
827
M03BC01
ATC
orphenadrine (citrate); systemic
3.4
29.8
132
473
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
39.8
29.7
37
10
M54.2
ICD-10 Finland
Cervicalgia
6.2
28.3
51
90
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.1
27.6
157
650
M01AH01
ATC
celecoxib; oral
3.4
26.7
120
431
N02AJ06
ATC
codeine and paracetamol; systemic
2.7
26.0
237
1251
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
98.8
25.9
28
*
N02BF02
ATC
pregabalin; oral
6.4
25.6
44
74
M01AH02
ATC
rofecoxib; oral
3.7
25.4
93
292
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
25.2
24
*
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
262.7
24.9
25
*
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
24.2
24.2
34
15
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
4.7
23.9
59
138
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.9
23.6
76
218
H02AB06
ATC
prednisolone; systemic
2.6
23.6
272
1589
M16.1
ICD-10 Finland
Other primary coxarthrosis
3.5
23.4
92
302
N02AA05
ATC
oxycodone; systemic
3.0
23.2
124
490
SPAT1301
SPAT
No procedures
2.7
23.1
188
927
E66.8
ICD-10 Finland
Other obesity
5.8
23.0
44
82
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
7.6
22.7
33
46
A07EC01
ATC
sulfasalazine; oral, rectal
4.5
22.7
59
144
NF1AA
NOMESCO Finland
Hip X-ray examination
4.0
22.6
70
195
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.7
22.1
154
700
M01AC06
ATC
meloxicam; systemic, rectal
2.5
22.0
215
1151
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.5
22.0
84
270
M47.81
ICD-10 Finland
Other spondylosis, occipito-atlanto-axial region
84.0
21.9
24
*
G47.3
ICD-10 Finland
Sleep apnoea
2.7
21.7
158
733
M79.6
ICD-10 Finland
Pain in limb
2.5
20.7
218
1201
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
21.2
20.6
30
15
R52.2
ICD-10 Finland
Other chronic pain
7.5
20.6
30
42
M25.5
ICD-10 Finland
Pain in joint
2.6
20.4
168
825
N02BE01
ATC
paracetamol; systemic, rectal
5.2
19.8
466
3747
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
19.7
179
917
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
208.0
19.7
20
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
208.0
19.7
20
*
M03BC51
ATC
orphenadrine, combinations; systemic
2.6
19.6
147
688
M79.1
ICD-10 Finland
Myalgia
3.3
19.4
84
291
A10BJ06
ATC
semaglutide; parenteral
4.6
19.2
48
113
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.5
19.2
173
882
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
4.2
19.0
53
136
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.0
18.9
99
383
A02BC05
ATC
esomeprazole; systemic
2.4
18.9
226
1303
L04AX03
ATC
methotrexate; systemic
3.6
18.5
67
207
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
31.4
18.5
24
8
A02BC03
ATC
lansoprazole; oral
2.5
18.5
166
843
Z01.8
ICD-10 Finland
Other specified special examinations
2.6
18.2
130
591
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
3.7
18.0
61
180
L13
ICPC
Hip symptom/complaint
2.8
17.8
109
458
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
17.8
17
*
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
5.8
17.7
33
60
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.9
17.7
56
158
M70.6
ICD-10 Finland
Trochanteric bursitis
3.2
17.4
75
259
M01AB05
ATC
diclofenac; systemic, rectal
2.4
17.4
340
2383
M54.1
ICD-10 Finland
Radiculopathy
15.5
17.3
28
19
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
5.5
17.3
34
65
A02BC02
ATC
pantoprazole; systemic
2.4
17.2
359
2581
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.8
16.6
99
409
205
Kela drug reimbursment
Chronic hypertension
2.3
16.6
176
954
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
2.9
16.0
86
336
M13.9
ICD-10 Finland
Arthritis, unspecified
3.7
16.0
54
159
C08CA01
ATC
amlodipine; oral
2.2
15.9
237
1469
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
15.8
267
1735
A10BA02
ATC
metformin; oral
2.2
15.8
192
1097
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.8
15.7
50
141
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
15.7
15
*
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
3.7
15.7
52
151
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.2
15.5
69
242
R07.4
ICD-10 Finland
Chest pain, unspecified
2.3
15.5
157
831
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.0
15.4
76
283
UJF32
NOMESCO Finland
Coloscopy
2.3
15.4
155
817
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
15.3
74
272
A02BC01
ATC
omeprazole; systemic
2.3
15.3
150
781
M77.1
ICD-10 Finland
Lateral epicondylitis
4.1
15.3
43
111
M01AE02
ATC
naproxen; oral, rectal
2.1
15.2
283
1899
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.7
15.1
96
409
C07AB07
ATC
bisoprolol; oral
2.1
15.1
281
1886
R03AC02
ATC
salbutamol; inhalant
2.1
14.9
268
1770
S18
ICPC
Laceration/cut
2.1
14.7
249
1606
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.2
14.7
167
923
B01AB05
ATC
enoxaparin; parenteral
2.2
14.7
181
1034
7216A
ICD-9 Finland
Spondylosis and allied disorders, Ankylosing vertebral hyperostosis
+∞
14.7
14
*
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
+∞
14.7
14
*
L01
ICPC
Neck symptom/complaint
2.9
14.6
75
285
M01AX05
ATC
glucosamine; oral
2.4
14.6
124
605
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.3
14.5
151
804
SPAT1153
SPAT
Removal of sutures
2.2
14.5
178
1014
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.2
14.5
163
897
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
14.4
198
1177
M01AX17
ATC
nimesulide; oral
2.3
14.4
138
710
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.2
14.4
166
922
SPAT1263
SPAT
Sampling
2.1
14.3
216
1331
SPAT1262
SPAT
Handing over of treatment supplies
2.4
14.3
119
576
J01MA02
ATC
ciprofloxacin; systemic
2.1
13.9
210
1290
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.5
13.8
50
154
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
5.9
13.8
25
44
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
13.6
13
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
13.6
162
908
J01AA02
ATC
doxycycline; systemic
2.4
13.5
394
3082
L01BA01
ATC
methotrexate; systemic
5.8
13.5
25
45
J01DB01
ATC
cefalexin; oral
2.5
13.4
414
3313
M02AA07
ATC
piroxicam; topical
2.1
13.4
189
1130
A46
ICD-10 Finland
Erysipelas
2.5
13.3
95
427
103
Kela drug reimbursment
Diabetes, insulin-treated
2.1
13.3
175
1018
Z50.1
ICD-10 Finland
Other physical therapy
4.0
13.3
39
104
A06AC01
ATC
ispaghula (psylla seeds); oral
2.2
13.2
143
770
I10
ICD-10 Finland
Essential (primary) hypertension
2.1
13.0
343
2558
M50.3
ICD-10 Finland
Other cervical disc degeneration
19.7
13.0
19
10
T90
ICPC
Diabetes non-insulin dependent
2.1
12.9
156
877
SAA01
NOMESCO Finland
Simple examination of mouth
2.1
12.8
346
2595
M79.0
ICD-10 Finland
Rheumatism, unspecified
10.4
12.6
24
24
M01AC01
ATC
piroxicam; systemic, rectal
2.6
12.6
81
346
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
2.7
12.6
73
296
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
+∞
12.5
12
*
M19.8
ICD-10 Finland
Other specified arthrosis
4.6
12.5
30
68
J01DA01
ATC
[U] cefalexin
2.0
12.3
304
2194
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.2
12.3
124
647
M43.0
ICD-10 Finland
Spondylolysis
38.6
12.3
15
*
M01AH03
ATC
valdecoxib; oral
3.7
12.1
39
111
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
5.6
11.9
23
43
N02AC04
ATC
dextropropoxyphene; oral
4.9
11.8
26
55
C10AA03
ATC
pravastatin; oral
3.1
11.8
52
181
N04BC05
ATC
pramipexole; oral
3.3
11.8
47
154
N06AX16
ATC
venlafaxine; oral
2.7
11.7
69
281
J01FF01
ATC
clindamycin; systemic
2.1
11.7
148
841
H02AB07
ATC
prednisone; oral
2.5
11.6
78
339
M79.7
ICD-10 Finland
Fibromyalgia
8.9
11.6
24
28
L84
ICPC
Back syndrome without radiat pain
4.5
11.6
29
68
A01
ICPC
Pain general/multiple sites
3.2
11.6
49
166
L28
ICPC
Limited function/disability (L)
2.4
11.5
91
427
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.4
11.5
42
130
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
+∞
11.5
11
*
AB5BT
NOMESCO Finland
Blockage of nerv root with X-ray guidance
+∞
11.5
11
*
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
+∞
11.5
11
*
WX704
NOMESCO Finland
Intubation
3.3
11.5
46
151
J45.9
ICD-10 Finland
Asthma, unspecified
2.3
11.4
94
450
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.9
11.3
225
1495
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.6
11.3
74
318
M01AX01
ATC
nabumetone; oral
4.3
11.2
29
70
R5140
NOMESCO Finland
Monitoring the use of the aid
2.6
11.1
72
308
R05DA20
ATC
opium alkaloids and derivatives - combinations
2.1
11.0
131
727
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.2
11.0
45
150
M53.0
ICD-10 Finland
Cervicocranial syndrome
3.5
10.9
39
119
A06AD11
ATC
lactulose; oral
2.4
10.9
82
376
H02AB04
ATC
methylprednisolone; systemic
2.4
10.9
80
363
N06AX11
ATC
mirtazapine; oral
2.0
10.8
160
960
L17
ICPC
Foot/toe symptom/complaint
2.0
10.7
142
819
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
14.6
10.6
17
12
M51.8
ICD-10 Finland
Other specified intervertebral disc disorders
112.3
10.5
11
*
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
+∞
10.5
10
*
G99.2*M47.1
ICD-10 Finland
Spondylogenic compression of spinal cord
+∞
10.5
10
*
L08
ICPC
Shoulder symptom/complaint
2.1
10.4
114
610
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
10.9
10.4
19
18
SPAT1202
SPAT
Intra-articular injection
4.9
10.3
23
49
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.2
10.3
98
497
R06.0
ICD-10 Finland
Dyspnoea
2.0
10.3
141
821
SPAT1058
SPAT
PEF monitoring instruction
3.0
10.2
46
162
N02AJ13
ATC
tramadol and paracetamol; systemic
9.4
10.1
20
22
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.3
10.1
38
120
Z3226
NOMESCO Finland
Physiotherapist
2.2
10.1
92
458
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.3
10.0
39
126
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
10.0
79
370
SPAT1249
SPAT
Treatment-related counselling outside office
1.9
9.9
189
1225
N06AB04
ATC
citalopram; systemic
2.1
9.9
103
540
E66.9
ICD-10 Finland
Obesity, unspecified
4.5
9.9
24
55
N06AA10
ATC
nortriptyline; systemic
9.0
9.9
20
23
M01AB01
ATC
indometacin; systemic, rectal
2.8
9.9
51
194
NA2AD
NOMESCO Finland
Thoracic spine CT examination
26.6
9.9
13
5
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
20.5
9.8
14
7
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.6
9.8
33
97
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
56.1
9.7
11
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.2
9.7
90
451
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.3
9.7
37
118
J02AC01
ATC
fluconazole; systemic
1.9
9.6
158
974
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.2
9.6
26
65
P01BA02
ATC
hydroxychloroquine; oral
2.9
9.6
46
168
R03AC03
ATC
terbutaline; inhalant
2.4
9.6
71
323
SFA10
NOMESCO Finland
One-surface restoration
1.8
9.5
257
1848
M01AB55
ATC
diclofenac, combinations; oral
3.1
9.5
40
135
SAA02
NOMESCO Finland
Basic examination of mouth
1.8
9.5
300
2261
R53
ICD-10 Finland
Malaise and fatigue
2.1
9.5
113
623
R05FB02
ATC
cough suppressants and expectorants; systemic
1.9
9.5
185
1205
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
9.5
167
1053
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
9.5
62
266
9211
FHL
Exploration or removal of diskusprolapse
+∞
9.4
9
*
M50.9
ICD-10 Finland
Cervical disc disorder, unspecified
+∞
9.4
9
*
WZC00
NOMESCO Finland
Treatment plan or consultation
1.9
9.3
180
1167
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
9.3
136
805
R35
ICD-10 Finland
Polyuria
3.0
9.3
42
148
SPAT1310
SPAT
Counselling related to known health issue
1.9
9.3
154
952
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
3.3
9.3
36
116
G44.2
ICD-10 Finland
Tension-type headache
2.5
9.2
59
250
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.7
9.2
51
201
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
9.2
93
481
WX110
NOMESCO Finland
Infiltration anesthesia
1.8
9.2
334
2617
SPAT1254
SPAT
Administration of medicine
2.3
9.1
76
363
J01DA08
ATC
[U] cefaclor
2.8
9.1
47
179
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.9
9.1
43
156
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
7.7
9.0
20
27
D10BA01
ATC
isotretinoin; oral
4.1
9.0
25
64
R03BA01
ATC
beclometasone; inhalant
2.4
9.0
68
312
C03CA01
ATC
furosemide; systemic
1.9
8.9
160
1012
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.2
8.9
36
119
KMAK, ,
NOMESCO Finland
1.8
8.9
230
1624
R52.9
ICD-10 Finland
Pain, unspecified
2.7
8.9
48
187
E66.00
ICD-10 Finland
Metabolic syndrome
3.1
8.9
38
130
M54
ICD-10 Finland
Dorsalgia
2.6
8.8
51
206
C01DA14
ATC
isosorbide mononitrate; oral
2.1
8.7
87
447
G56.2
ICD-10 Finland
Lesion of ulnar nerve
4.4
8.7
22
52
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.2
8.7
35
115
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
8.7
113
641
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
8.7
84
427
J01FA06
ATC
roxithromycin; oral
1.8
8.7
190
1275
R20.2
ICD-10 Finland
Paraesthesia of skin
3.3
8.7
33
105
M02AA10
ATC
ketoprofen; topical
2.2
8.6
81
408
G55.1*M51.9
ICD-10 Finland
Nerve root and plexus compressions in intervertebral disc disorders (M50-M51+)
28.1
8.5
11
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
8.5
198
1352
C10AA01
ATC
simvastatin; oral
1.7
8.5
240
1732
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
3.9
8.4
25
67
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.4
8.4
63
288
R4110, ,
SPAT
2.6
8.4
50
205
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
+∞
8.4
8
*
NAG66
NOMESCO Finland
Posterior interbody fusion of lumbar spine, 2 vertebrae
+∞
8.4
8
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.9
8.3
40
146
K02.1
ICD-10 Finland
Caries of dentine
1.7
8.3
267
1993
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.7
8.3
256
1889
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
8.2
199
1369
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
3.7
8.2
26
73
M01AE01
ATC
ibuprofen; systemic, rectal
2.2
8.2
432
3740
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.9
8.2
115
670
SPAT1216
SPAT
Assessment of functional ability
2.1
8.1
83
430
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
7.0
8.1
19
28
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.7
8.1
211
1480
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.8
8.1
41
154
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.8
8.1
25
69
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
33.9
8.1
10
*
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
9.1
8.1
16
18
G54.0
ICD-10 Finland
Brachial plexus disorders
10.3
8.1
15
15
C10AX09
ATC
ezetimibe; oral
2.0
8.0
95
520
R10.0
ICD-10 Finland
Acute abdomen
4.6
8.0
19
43
NF1DA
NOMESCO Finland
X-ray of hips
6.3
7.9
20
33
M01AE51
ATC
ibuprofen, combinations; systemic
11.0
7.8
14
13
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.8
7.8
39
146
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
45.7
7.7
9
*
SFA00
NOMESCO Finland
Small restoration
2.2
7.7
71
353
Z3231
NOMESCO Finland
Registered nurse
1.8
7.7
132
817
A10BK03
ATC
empagliflozin; oral
2.2
7.7
67
326
C10AA07
ATC
rosuvastatin; oral
1.8
7.7
168
1119
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
3.4
7.6
27
82
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
2.5
7.6
51
221
SFA20
NOMESCO Finland
Two-surface restoration
1.7
7.6
269
2042
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.9
7.6
105
607
AA1AD
NOMESCO Finland
CT of head and brain
1.8
7.5
138
872
M77.9
ICD-10 Finland
Enthesopathy, unspecified
4.5
7.5
18
41
R42
ICD-10 Finland
Dizziness and giddiness
1.9
7.5
107
625
H29
ICPC
Ear symptom/complaint other
2.3
7.5
60
282
R01AD09
ATC
mometasone; nasal
1.7
7.5
195
1363
M09AX01
ATC
hyaluronic acid; parenteral
3.2
7.4
30
99
SPAT1234
SPAT
Support of social functional capacity
3.2
7.4
30
99
N03AX09
ATC
lamotrigine; oral
4.1
7.4
20
50
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.6
7.4
45
186
R06AE07
ATC
cetirizine; oral
1.7
7.4
182
1252
M51.2
ICD-10 Finland
Other specified intervertebral disc displacement
+∞
7.3
7
*
72880
ICD-8 Finland
Vertebrogenic pain syndrome, Radicula syndrome of lower limbs
+∞
7.3
7
*
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
+∞
7.3
7
*
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
+∞
7.3
7
*
NAG65
NOMESCO Finland
Anterior and posterior fusion of lumbar spine
+∞
7.3
7
*
72510
ICD-8 Finland
Displacement of intervertebral disk, Lumbalis cum prolapsu disci
+∞
7.3
7
*
R60.0
ICD-10 Finland
Localized oedema
2.3
7.3
60
285
K30
ICD-10 Finland
Functional dyspepsia
2.4
7.3
51
226
M15
ICD-10 Finland
Polyarthrosis
3.2
7.2
28
90
SPAT1260
SPAT
Consultation of another employee
2.0
7.2
87
479
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
7.2
71
363
SPAT1097
SPAT
Recording of ECG
2.0
7.2
83
450
R52.1
ICD-10 Finland
Chronic intractable pain
30.5
7.2
9
*
M54.0
ICD-10 Finland
Panniculitis affecting regions of neck and back
20.4
7.2
10
5
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
3.9
7.2
21
56
M01AE52
ATC
naproxen and esomeprazole; oral
3.9
7.2
21
56
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.9
7.2
21
56
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.1
7.1
68
343
M84.1
ICD-10 Finland
Nonunion of fracture [pseudarthrosis]
9.0
7.1
14
16
C10AA05
ATC
atorvastatin; oral
1.7
7.1
229
1687
J01DA09
ATC
[U] cefadroxil
1.8
7.1
128
804
UKC02
NOMESCO Finland
Cystoscopy
2.0
7.1
88
490
L04AA13
ATC
[U] leflunomide
7.2
7.0
16
23
E0000UV, ,
ATC
1.7
7.0
186
1301
G04BD07
ATC
tolterodine; oral
3.2
7.0
27
87
R02
ICPC
Shortness of breath/dyspnoea
2.2
7.0
64
318
H93.1
ICD-10 Finland
Tinnitus
2.6
7.0
40
161
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.3
6.9
26
82
XF402
NOMESCO Finland
ECG with work load test
2.2
6.9
61
298
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
14.0
6.9
11
8
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.1
6.9
66
333
WZA90
NOMESCO Finland
Other medical or dental certificate
1.8
6.9
109
656
A02BA02
ATC
ranitidine; systemic
1.9
6.9
96
555
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
3.1
6.9
28
93
A10BJ02
ATC
liraglutide; parenteral
3.9
6.9
20
53
C07AB02
ATC
metoprolol; systemic
1.9
6.9
101
594
A11
ICPC
Chest pain NOS
2.4
6.8
47
206
H04.10
ICD-10 Finland
Dry eye syndrome
2.3
6.8
51
232
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.8
6.8
34
127
D07XC01
ATC
betamethasone; topical
2.1
6.8
69
356
L15
ICPC
Knee symptom/complaint
1.8
6.8
110
667
SPAT1312
SPAT
General health counselling
1.7
6.8
142
929
R13
ICD-10 Finland
Dysphagia
2.7
6.8
37
145
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
6.8
90
512
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.5
6.7
42
176
C08CA13
ATC
lercanidipine; oral
2.0
6.7
80
438
UJD02
NOMESCO Finland
Gastroscopy
3.0
6.7
29
100
3015
Kela drug reimbursment
Alirocumab and evolocumab for the treatment of hypercholesterolaemia and dyslipidaemia
22.9
6.7
9
*
B01AF01
ATC
rivaroxaban; oral
2.0
6.7
75
402
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.5
6.7
43
183
ACC51
NOMESCO Finland
Release of median nerve
2.8
6.6
33
123
P01AB01
ATC
metronidazole; oral, rectal
1.7
6.6
175
1218
R51.80
ICD-10 Finland
Headache
2.2
6.6
58
283
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
4.3
6.6
17
41
A03FA02
ATC
cisapride; oral, rectal
2.5
6.5
40
166
G04BD09
ATC
trospium; oral
5.5
6.5
18
34
L99
ICPC
Musculoskeletal disease other
6.3
6.5
16
26
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.3
6.5
49
224
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.3
6.5
52
244
M01AE11
ATC
tiaprofenic acid; oral, rectal
3.1
6.5
27
91
J01EA01
ATC
trimethoprim; systemic
1.8
6.5
110
676
SPAT1212
SPAT
Extensive examination of musculoskeletal system
2.5
6.5
40
167
M40.2
ICD-10 Finland
Other and unspecified kyphosis
70.7
6.4
7
*
M48.9
ICD-10 Finland
Spondylopathy, unspecified
70.7
6.4
7
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.6
6.4
37
149
NA2AA, ,
SPAT
14.5
6.4
10
7
R11
ICD-10 Finland
Nausea and vomiting
2.5
6.4
40
168
D07AC01
ATC
betamethasone; topical
1.7
6.4
170
1184
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
6.7
6.4
15
23
L60.0
ICD-10 Finland
Ingrowing nail
3.0
6.4
27
92
M03BX01
ATC
baclofen; systemic
6.1
6.3
16
27
Z02.7
ICD-10 Finland
Issue of medical certificate
2.6
6.3
36
144
M01AB08
ATC
etodolac; oral
2.7
6.3
35
138
M04AA01
ATC
allopurinol; systemic
2.0
6.3
78
432
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
6.3
90
523
N05AH04
ATC
quetiapine; oral
2.0
6.3
71
381
J45
ICD-10 Finland
Asthma
2.4
6.3
42
182
J01CF05
ATC
flucloxacillin; systemic
2.7
6.3
33
127
L04
ICPC
Chest symptom/complaint
2.7
6.3
33
127
G99.2*M47.9
ICD-10 Finland
Myelopathy in spondylosis
+∞
6.3
6
*
AEA24
NOMESCO Finland
Removal of spinal stimulation elecrode
+∞
6.3
6
*
ABC66
NOMESCO Finland
Decompression of lumbal spinal channel
+∞
6.3
6
*
L85
ICPC
Acquired deformity of spine
+∞
6.3
6
*
M53.2
ICD-10 Finland
Spinal instabilities
+∞
6.3
6
*
NA3SA
NOMESCO Finland
Lumbar spine X-ray examination in standing position
27.0
6.2
8
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.2
6.2
53
255
M77.4
ICD-10 Finland
Metatarsalgia
2.8
6.2
31
116
SPAT1229
SPAT
Assessment of need for aid
2.5
6.2
38
158
R01AD01
ATC
beclometasone; nasal
2.0
6.2
69
369
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
6.2
64
333
J01FA10
ATC
azithromycin; systemic
1.6
6.1
238
1814
ZXD35
NOMESCO Finland
Usual procedure
3.7
6.1
19
53
J01AA07
ATC
tetracycline; systemic
2.1
6.1
61
314
SPAT1255
SPAT
Intravenous administration of medicine
2.5
6.0
38
160
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.3
6.0
45
205
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
398
2807
3.13
23.56
5.6
3.7
13.72
13.00
mm/h
0.41
377
2550
340
2337
2.45
18.90
5.0
4.8
7.05
6.84
mmol/l
0.95
318
2200
125
554
2.68
18.48
1.4
1.2
16.68
40.30
iu/ml
3.08
32
171
117
518
2.65
17.22
1.4
1.2
8.78
14.90
u/ml
0.52
45
202
318
2188
2.27
16.66
8.4
9.9
4.23
4.16
e9/l
0.22
286
1912
397
3042
2.54
15.60
8.5
7.7
79.57
79.54
u/l
0.00
384
2845
289
1953
2.15
15.30
19.4
14.7
1.34
1.30
inr
0.30
79
609
258
1688
2.10
14.65
5.0
5.0
35.97
35.11
g/l
1.76
242
1572
195
1169
2.10
13.76
2.3
2.0
235.11
297.25
u/l
0.34
178
1092
460
3876
3.64
13.68
20.7
14.0
20.72
26.93
mg/l
4.58
404
3042
271
1839
2.05
13.57
4.8
3.2
0.00
0.01
estimate
0.50
37
337
263
1771
2.03
13.40
3.0
2.6
—
—
—
0
0
179
1052
2.10
13.21
2.6
2.7
8017.16
7309.38
umol/l
0.06
166
922
142
763
2.21
13.20
5.6
3.5
1.02
1.02
kg/l
0.31
22
116
264
1824
1.96
12.04
6.2
4.5
0.00
0.00
estimate
-0.00
43
357
263
1823
1.94
11.80
4.8
3.3
0.00
0.00
estimate
-0.00
49
373
231
1537
1.94
11.67
4.3
3.6
25.58
48.37
ng/l
2.82
165
1150
290
2091
1.93
11.41
6.0
6.8
10.81
12.43
umol/l
1.72
274
1985
212
1382
1.93
11.28
4.1
3.8
6.80
7.96
mg/mmol
0.20
161
891
216
1427
1.91
10.96
5.2
3.4
—
—
—
0
0
81
373
2.40
10.65
1.9
2.1
134.87
147.30
ug/g
0.20
65
301
326
2501
1.89
9.99
6.0
3.9
22.33
3538.73
e6/l
—
6
44
357
2827
1.94
9.85
4.6
3.6
15.26
14.97
pmol/l
1.35
337
2516
218
1484
1.84
9.76
2.6
2.1
73.03
76.79
nmol/l
1.44
201
1307
266
1934
1.81
9.50
7.9
7.0
1.21
1.21
mmol/l
0.03
241
1628
229
1598
1.81
9.33
2.3
2.0
93.09
95.38
pmol/l
0.28
133
856
420
3560
2.19
9.06
5.8
4.3
1.81
2.32
mu/l
0.84
396
3179
442
3826
2.45
9.05
8.6
5.9
42.58
40.33
mmol/mol
4.63
422
3503
198
1339
1.80
8.84
3.3
3.2
8.04
7.88
mmol/l
0.21
173
1117
217
1509
1.78
8.80
3.5
2.6
154.66
162.32
ug/l
0.18
202
1366
250
1832
1.74
8.29
6.8
6.1
28.15
26.91
%
0.93
231
1726
180
1202
1.78
8.27
3.2
3.2
926.16
1401.03
ng/l
1.75
160
1040
246
1805
1.72
8.03
6.7
5.9
57.42
57.69
%
0.12
226
1704
110
636
1.94
7.96
1.9
1.9
—
—
—
0
0
467
4202
2.97
7.84
23.8
16.4
139.83
139.67
mmol/l
0.79
460
4077
468
4217
3.01
7.81
24.0
16.5
4.01
3.99
mmol/l
0.93
461
4085
107
617
1.94
7.79
2.8
2.4
12.20
12.97
umol/l
0.57
100
572
62
294
2.27
7.56
2.9
2.6
62.16
58.96
ml/min/173m2
0.23
25
106
124
762
1.84
7.39
1.8
1.7
1.36
1.39
mg/l
0.02
94
601
28
90
3.24
7.25
1.4
1.1
—
—
—
0
0
182
1260
1.70
7.14
3.6
3.3
34.25
48.85
u/l
0.58
175
1200
83
452
2.00
7.09
5.0
8.1
1.89
1.29
mmol/l
0.82
66
372
28
92
3.17
7.00
1.4
1.1
—
—
—
0
0
151
998
1.74
6.98
5.6
3.4
0.00
0.01
estimate
0.50
42
342
90
516
1.91
6.60
4.9
7.5
103.80
104.36
mmol/l
0.56
90
516
93
540
1.89
6.56
2.8
2.4
18.90
23.12
%
2.41
78
468
79
436
1.97
6.48
1.8
1.9
—
—
—
0
0
79
439
1.95
6.35
1.7
1.8
—
—
—
0
0
233
1759
1.61
6.31
6.6
6.0
1.20
1.21
mmol/l
0.61
218
1599
96
571
1.85
6.27
2.9
2.4
2.36
2.26
g/l
1.27
87
529
111
693
1.78
6.18
1.4
1.2
3.85
1.26
u/ml
0.51
26
183
66
348
2.03
6.14
3.1
2.3
4.98
7.24
ug/l
0.94
61
306
29
106
2.84
6.06
1.7
1.3
—
—
—
0
0
143
966
1.68
5.97
2.7
2.0
3.10
3.10
mg/l
0.01
128
816
466
4273
2.55
5.95
13.9
10.3
27.82
27.11
u/l
0.38
457
4098
179
1286
1.61
5.84
3.0
3.8
2.35
2.35
mmol/l
0.19
160
1137
25
86
3.01
5.81
1.0
1.1
—
8.40
—
0
13
116
746
1.72
5.79
4.2
3.6
409.62
410.22
ng/l
0.00
92
610
34
141
2.52
5.59
1.5
1.3
—
—
—
0
0
439
3956
1.97
5.49
6.3
4.6
6.30
6.06
mmol/l
3.37
410
3555
74
422
1.89
5.49
1.4
1.3
—
—
—
0
0
110
710
1.71
5.39
1.9
1.7
1103.52
1132.02
nmol/l
0.14
97
540
29
115
2.62
5.22
1.0
1.0
—
—
u/ml
—
0
0
125
842
1.65
5.20
1.9
1.7
99115425.25
14349525.41
pmol/l
0.62
113
676
305
2553
1.51
4.61
3.6
3.0
51.72
58.23
u/l
0.94
288
2358
62
354
1.86
4.58
4.0
3.6
3.36
2.04
mmol/l
1.69
54
280
447
4110
1.90
4.41
6.5
5.0
2.59
2.70
mmol/l
1.89
425
3737
37
178
2.17
4.39
4.0
2.6
1.17
1.18
%
0.03
37
178
190
1458
1.49
4.33
4.2
3.0
—
—
—
0
0
472
4434
2.39
4.24
30.8
20.6
40.04
40.48
%
0.57
436
4126
53
300
1.86
4.03
4.2
2.9
4.55
4.66
kpa
0.13
53
289
130
938
1.52
3.92
1.7
1.5
19.84
21.18
nmol/l
0.49
119
784
49
274
1.87
3.87
1.9
1.6
—
—
—
0
0
75
476
1.68
3.87
11.0
6.2
—
—
—
0
0
35
174
2.09
3.85
4.1
2.5
0.75
0.67
%
0.68
35
174
41
218
1.96
3.76
2.2
2.5
—
17.08
—
0
12
103
713
1.56
3.74
3.0
3.4
2.44
2.45
mmol/l
0.69
89
640
247
2042
1.42
3.61
2.5
2.4
—
—
—
0
0
7
9
7.87
3.57
1.3
1.8
259.43
225.56
u/l
—
7
9
25
112
2.30
3.54
1.4
1.5
0.02
0.04
iu/ml
—
6
14
436
4031
1.68
3.52
6.0
4.5
4.44
4.58
mmol/l
2.25
412
3692
433
4003
1.65
3.41
5.7
4.4
1.35
1.43
mmol/l
4.71
407
3639
127
940
1.47
3.34
2.7
2.4
—
—
—
0
0
70
459
1.61
3.18
3.3
2.7
7.96
9.83
umol/l
0.48
62
409
19
79
2.46
3.17
1.1
1.1
2.54
3.02
u/ml
—
5
12
55
343
1.68
3.04
5.4
7.7
1.18
1.41
mmol/l
1.59
55
338
39
220
1.84
3.03
1.6
1.4
—
—
—
0
0
419
3870
1.54
3.01
5.3
4.0
1.45
1.30
mmol/l
4.25
395
3497
45
269
1.74
2.90
4.3
3.9
104.42
86.33
ng/l
0.66
40
229
35
199
1.82
2.68
1.2
1.3
—
68.09
—
0
11
15
61
2.50
2.64
1.4
1.9
—
—
—
0
0
21
100
2.15
2.62
1.4
1.3
—
—
—
0
0
22
107
2.11
2.61
1.7
1.5
—
—
—
0
0
41
248
1.71
2.56
3.3
4.1
3.10
2.20
mmol/l
0.70
28
196
10
32
3.17
2.45
1.5
1.8
—
—
—
0
0
10
32
3.17
2.45
2.6
2.6
—
—
—
0
0
23
118
2.00
2.39
1.8
1.6
—
—
—
0
0
15
65
2.35
2.33
1.4
1.8
—
—
—
0
0
23
121
1.94
2.24
1.9
2.4
102.35
93.69
ug/min
0.04
14
75
89
664
1.41
2.21
3.2
2.7
0.73
1.22
e6/l
1.84
60
382
225
1933
1.30
2.20
5.6
4.8
2.20
2.57
ug/l
0.64
206
1716
16
74
2.20
2.17
1.2
1.4
—
—
—
0
0
15
68
2.24
2.13
1.4
1.8
—
—
—
0
0
9
31
2.94
2.08
1.2
1.2
—
—
—
0
0
16
76
2.14
2.04
1.1
1.2
—
—
—
0
0
18
91
2.01
1.97
3.1
2.7
17.20
16.30
%
0.41
12
48
7
21
3.37
1.97
1.3
1.8
—
—
—
0
0
7
21
3.37
1.97
1.3
1.8
—
—
—
0
0
8
27
2.99
1.94
1.6
2.0
—
—
—
0
0
148
1221
1.30
1.91
4.2
3.1
93.84
130.01
e6/l
0.18
122
953
135
1101
1.31
1.90
4.1
3.0
0.27
0.52
e6/l
1.55
111
840
26
152
1.75
1.87
1.8
1.7
—
—
—
0
0
183
1556
1.28
1.87
5.0
4.0
19.60
21.58
%
1.44
93
768
8
28
2.89
1.87
1.6
1.9
—
—
—
0
0
6
17
3.56
1.84
1.2
1.0
—
—
—
0
0
6
17
3.56
1.84
1.2
1.4
—
—
—
0
0
5
12
4.20
1.82
1.8
2.2
44200.00
43033.33
ug/l
—
5
12
49
339
1.49
1.81
2.9
2.1
13.96
13.11
nmol/l
0.24
41
310
15
74
2.06
1.76
1.4
1.9
—
—
—
0
0
26
155
1.71
1.76
1.4
1.5
—
—
—
0
0
412
3891
1.35
1.73
17.2
13.5
78.28
78.32
ml/min/173m2
0.01
366
3228
60
439
1.42
1.68
1.7
1.7
1.49
1.60
%
0.71
55
369
46
320
1.48
1.67
3.9
2.8
67.63
66.46
g/l
0.48
41
295
18
312
0.56
1.64
1.8
1.8
—
—
—
0
0
6
20
3.02
1.58
1.3
1.8
—
—
—
0
0
6
20
3.02
1.58
1.3
1.8
—
—
—
0
0
12
57
2.13
1.56
1.8
2.5
106.42
104.96
mmol/l
0.46
12
57
12
57
2.13
1.56
1.8
2.5
3.91
4.01
mmol/l
0.32
12
57
82
641
1.33
1.55
3.3
2.8
1.50
1.70
e6/l
0.18
54
363
7
28
2.52
1.45
1.1
1.4
—
—
—
0
0
131
1105
1.25
1.38
1.9
1.6
1.52
1.37
mmol/l
1.14
114
899
17
97
1.78
1.36
1.5
2.1
—
—
—
0
0
27
176
1.56
1.34
1.4
1.5
—
—
—
0
0
9
43
2.11
1.31
1.0
1.1
—
—
—
0
0
10
48
2.11
1.28
1.6
1.7
—
—
—
0
0
10
48
2.11
1.28
1.6
1.7
—
—
—
0
0
10
48
2.11
1.28
1.6
1.7
—
—
—
0
0
9
45
2.02
1.24
1.1
2.0
—
—
—
0
0
25
164
1.55
1.23
2.1
1.9
—
—
—
0
0
10
49
2.06
1.22
1.6
1.7
—
—
—
0
0
10
49
2.06
1.22
1.6
1.7
—
—
—
0
0
10
49
2.06
1.22
1.6
1.7
—
—
—
0
0
12
64
1.90
1.19
2.8
2.6
3.32
4.34
e9/l
1.35
12
64
8
39
2.07
1.15
1.5
1.9
—
—
—
0
0
5
21
2.39
1.09
1.0
1.2
6.80
30.77
u/l
—
5
21
5
21
2.39
1.09
1.0
1.2
54.80
97.28
u/l
—
5
21
12
67
1.81
1.05
1.8
1.3
—
—
—
0
0
12
67
1.81
1.05
1.8
1.3
—
—
—
0
0
9
46
1.97
1.04
1.1
1.2
8.10
7.98
mmol/l
—
9
38
11
61
1.82
0.99
1.3
1.4
—
—
—
0
0
5
23
2.19
0.98
1.2
1.1
—
—
—
0
0
5
23
2.19
0.98
1.0
1.1
—
—
—
0
0
26
182
1.45
0.98
1.1
1.2
206.38
131.86
iu/ml
—
9
77
10
54
1.87
0.97
1.4
1.9
—
—
—
0
0
12
70
1.73
0.93
1.4
1.8
—
—
—
0
0
12
70
1.73
0.93
2.8
2.9
51.50
57.21
%
1.04
12
70
8
42
1.92
0.89
1.1
1.2
191.50
394.25
pmol/l
—
8
36
34
256
1.35
0.87
1.8
1.6
—
—
—
0
0
14
88
1.61
0.85
1.4
1.8
—
—
—
0
0
8
48
1.68
0.79
1.8
1.6
—
—
—
0
0
12
75
1.61
0.75
1.2
1.1
—
—
—
0
0
5
24
2.09
0.74
1.2
1.4
—
74.29
—
0
7
5
24
2.09
0.74
1.0
6.5
—
41.20
—
0
5
54
445
1.24
0.74
3.8
3.0
—
—
—
0
0
5
25
2.01
0.73
2.4
3.6
—
—
—
0
0
10
60
1.68
0.72
1.2
1.9
—
—
—
0
0
44
355
1.26
0.72
2.4
2.2
40.85
42.76
u/l
0.04
39
313
7
43
1.64
0.67
1.3
2.0
—
—
—
0
0
13
86
1.53
0.66
1.8
1.6
—
—
—
0
0
22
163
1.37
0.65
1.5
2.2
41.54
37.83
u/l
0.41
22
142
11
73
1.52
0.56
1.3
1.1
—
—
—
0
0
6
37
1.63
0.55
1.2
1.1
—
—
—
0
0
22
170
1.31
0.52
5.5
4.2
24.35
24.21
mmol/l
0.06
22
165
14
100
1.41
0.52
1.5
1.8
—
—
—
0
0
14
100
1.41
0.52
5.1
3.9
15.99
33.28
mg/l
—
8
62
12
86
1.41
0.45
1.6
1.5
—
—
—
0
0
11
78
1.42
0.43
1.5
1.2
—
—
—
0
0
15
113
1.34
0.43
1.3
1.8
—
—
—
0
0
8
57
1.41
0.42
1.3
1.1
119.62
113.19
%
—
8
52
0
15
0.00
0.41
0.0
1.0
—
1496.47
—
0
15
0
17
0.00
0.40
0.0
1.6
—
—
—
0
0
14
106
1.33
0.39
1.1
2.2
14.71
12.57
mg/l
0.39
14
97
5
35
1.43
0.39
1.4
1.1
—
—
—
0
0
15
115
1.31
0.39
1.3
1.8
—
—
—
0
0
20
161
1.25
0.37
2.5
3.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
18
143
1.27
0.37
2.3
2.7
0.25
0.37
u/ml
—
10
80
5
77
0.65
0.36
1.0
1.2
—
—
—
0
0
6
43
1.40
0.35
5.3
3.7
—
—
—
0
0
6
87
0.69
0.33
1.3
1.4
—
—
—
0
0
19
155
1.23
0.33
1.0
1.0
—
—
—
0
0
10
74
1.36
0.32
1.0
1.2
2.00
53.37
e6/l
—
10
59
10
74
1.36
0.32
1.1
1.4
130.40
150.92
e6/l
—
10
60
7
97
0.72
0.31
1.0
1.3
—
—
—
0
0
7
55
1.28
0.30
1.3
1.1
—
—
—
0
0
14
115
1.22
0.23
2.2
1.6
32.86
41.35
nmol/l
1.46
14
110
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
11
89
1.24
0.21
1.3
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
13
108
1.21
0.20
1.5
1.5
—
—
—
0
0
7
59
1.19
0.18
1.0
1.1
1.55
1.54
g/l
—
7
54
7
63
1.11
0.17
1.0
1.1
—
—
—
0
0
120
1154
1.05
0.17
3.2
2.9
0.58
0.77
ug/l
3.49
83
788
14
121
1.16
0.15
2.5
2.5
3.39
3.87
g/l
0.57
14
113
11
93
1.19
0.14
3.7
6.6
—
252.55
—
0
11
17
151
1.13
0.13
3.0
2.0
—
—
—
0
0
13
115
1.13
0.10
1.5
1.7
—
—
—
0
0
5
46
1.09
0.09
2.4
3.1
—
—
—
0
0
6
56
1.07
0.08
1.0
1.2
—
—
—
0
0
53
549
0.96
0.07
5.0
4.6
29.91
31.27
%
0.45
43
362
14
128
1.10
0.06
2.1
2.1
98.00
88.55
%
0.84
14
123
50
488
1.03
0.03
3.9
4.8
5.61
37.05
ug/l
1.17
40
410
38
371
1.03
0.02
1.5
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.8
—
—
—
0
0
5
51
0.98
-0.00
1.4
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.5
—
39.33
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.8
—
—
—
0
0
7
77
0.91
-0.00
1.1
1.7
—
—
—
0
0
5
50
1.00
-0.00
1.4
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.6
—
5.94
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
7
77
0.91
-0.00
1.1
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
23.55
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint M13_FORESTIER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FORESTIER | 1.208 [1.03, 1.42] | 0.021 |
| Birth year | 0.99 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 210 out of 1048 females with M13_FORESTIER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FORESTIER | 1.194 [1.04, 1.37] | 0.012 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 338 out of 1527 males with M13_FORESTIER died.
Mortality risk
Mortality risk for people of age
years, who have M13_FORESTIER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.213% |
| 5 | 0.511% | 1.204% |
| 10 | 1.405% | 3.308% |
| 15 | 2.672% | 6.12% |
| 20 | 4.768% | 10.485% |
Relationships between endpoints
↥Index endpoint: M13_FORESTIER – Ankylosing hyperostosis [Forestier]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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