diffuse idiopathic skeletal hyperostosis: This syndrome is characterized by the association of ankylosing vertebral hyperostosis with hyperkeratosis of the soles and palms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
473 |
4. Check minimum number of eventsNone |
473 |
5. Include endpointsNone |
473 |
6. Filter based on genotype QC (FinnGen only) |
473 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M48
- Name in latin
- Hyperostosis ancylopoetica
Similar endpoints
↥List of similar endpoints to
Ankylosing hyperostosis [Forestier]
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3079 | 1249 | 1805 |
| Only index persons | 2836 | 1179 | 1657 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.05 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 58.00 | 58.94 | 57.26 |
| Only index persons | 57.53 | 58.39 | 56.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 473 | 193 | 280 |
| Unadjusted period prevalence (%) | 0.10 | 0.07 | 0.12 |
| Median age at first event (years) | 57.67 | 57.24 | 57.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 430
- Matched controls
- 4300
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M48.1
ICD-10 Finland
Ankylosing hyperostosis [Forestier]
4503599627370496.0
323.0
418
*
M48.0
ICD-10 Finland
Spinal stenosis
144.9
141.8
145
15
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
90.8
109.5
119
18
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
902.8
79.0
75
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
56.5
64.0
75
16
N03AX12
ATC
gabapentin; oral
10.0
62.1
136
189
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
31.3
61.4
82
32
N03AX16
ATC
pregabalin; oral
7.4
60.8
170
348
M54.5
ICD-10 Finland
Low back pain
6.4
60.2
200
517
N02AX02
ATC
tramadol; systemic, rectal
5.3
56.9
269
1030
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
9.5
52.7
117
162
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
14.0
51.6
92
82
M54.6
ICD-10 Finland
Pain in thoracic spine
17.6
49.8
80
55
M54.4
ICD-10 Finland
Lumbago with sciatica
10.0
48.7
104
133
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
115.4
47.9
51
5
M54.9
ICD-10 Finland
Dorsalgia, unspecified
13.3
45.7
83
76
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
52.4
43.0
51
11
M47.9
ICD-10 Finland
Spondylosis, unspecified
67.2
42.2
48
8
M47.82
ICD-10 Finland
Other spondylosis, cervical region
35.8
37.5
48
15
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.5
33.2
252
1241
M45
ICD-10 Finland
Ankylosing spondylitis
348.2
32.3
32
*
M01AH05
ATC
etoricoxib; oral
3.4
30.5
296
1705
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
20.3
29.4
44
24
M43.1
ICD-10 Finland
Spondylolisthesis
68.9
28.3
32
5
L03
ICPC
Low back symptom/complaint
4.0
28.1
131
421
M03BX02
ATC
tizanidine; oral
3.2
27.8
291
1714
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
23.7
27.5
39
18
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
55.5
26.6
31
6
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
24.2
23
*
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
34.4
22.7
29
9
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
66.1
22.1
25
*
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
26.7
22.1
30
12
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
231.2
21.8
22
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
3.0
21.8
162
719
M53.1
ICD-10 Finland
Cervicobrachial syndrome
6.2
21.7
61
112
L86
ICPC
Back syndrome with radiating pain
9.3
21.0
44
52
L02
ICPC
Back symptom/complaint
5.7
20.9
63
126
N06AX21
ATC
duloxetine; oral
5.5
20.7
64
132
N02BE01
ATC
paracetamol; systemic, rectal
3.8
20.1
388
3047
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
14.1
20.1
34
26
M54.3
ICD-10 Finland
Sciatica
12.2
19.9
36
32
M01AH02
ATC
rofecoxib; oral
3.9
19.7
88
264
N06AA09
ATC
amitriptyline; systemic
5.2
19.5
64
141
M01AH01
ATC
celecoxib; oral (coxibs)
3.5
19.2
102
351
N02AJ06
ATC
codeine and paracetamol; systemic
2.7
19.1
182
927
M03BC01
ATC
orphenadrine (citrate); systemic
3.2
19.1
115
436
M01AC06
ATC
meloxicam; systemic, rectal
2.7
19.0
186
960
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
18.9
18
*
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
198.2
18.7
19
*
A02BC05
ATC
esomeprazole; systemic
2.6
18.6
199
1077
M54.1
ICD-10 Finland
Radiculopathy
23.0
18.4
26
12
E66.01
ICD-10 Finland
Obesity due to excess calories
5.6
18.0
54
107
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
21.2
18.0
26
13
M47.81
ICD-10 Finland
Other spondylosis, occipito-atlanto-axial region
69.6
17.9
20
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
4.9
17.6
60
138
N02AA05
ATC
oxycodone; systemic
3.4
17.1
92
317
H02AB06
ATC
prednisolone; systemic
2.4
17.0
228
1370
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
16.8
16
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.8
16.7
127
556
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
176.5
16.6
17
*
M79.6
ICD-10 Finland
Pain in limb
2.6
16.4
160
809
M54.8
ICD-10 Finland
Other dorsalgia
9.7
15.5
31
34
R03AC02
ATC
salbutamol; inhalant
2.3
15.4
226
1394
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
4.8
15.1
51
116
A02BC03
ATC
lansoprazole; oral
2.5
15.1
149
754
M70.6
ICD-10 Finland
Trochanteric bursitis
4.0
14.7
62
175
7216A
ICD-9 Finland
Spondylosis and allied disorders, Ankylosing vertebral hyperostosis
+∞
14.7
14
*
A02BC02
ATC
pantoprazole; systemic
2.3
14.6
289
2034
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.6
14.5
122
560
NF1AA
NOMESCO Finland
Hip X-ray examination
3.9
14.4
61
173
M79.1
ICD-10 Finland
Myalgia
3.8
14.4
63
184
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
14.3
221
1381
M50.3
ICD-10 Finland
Other cervical disc degeneration
44.1
14.2
17
*
M25.5
ICD-10 Finland
Pain in joint
2.6
14.2
129
618
M01AE02
ATC
naproxen; oral, rectal
2.2
14.0
245
1613
A10BA02
ATC
metformin; oral
2.3
13.7
162
885
SPAT1301
SPAT
No procedures
2.3
13.6
158
856
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
13.6
13
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
3.3
13.4
71
241
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.4
13.3
135
684
G47.3
ICD-10 Finland
Sleep apnoea
2.5
13.3
125
609
C07AB07
ATC
bisoprolol; oral
2.1
13.0
234
1541
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
7.2
12.9
31
46
A06AC01
ATC
ispaghula (psylla seeds); oral
2.5
12.9
118
565
SAA01
NOMESCO Finland
Simple examination of mouth
2.2
12.9
290
2100
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.3
12.8
68
231
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
12.7
142
749
M54.2
ICD-10 Finland
Cervicalgia
6.0
12.7
35
63
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.3
12.6
150
818
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
+∞
12.6
12
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.3
12.3
132
682
I10
ICD-10 Finland
Essential (primary) hypertension
2.1
12.2
286
2080
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
4.3
12.1
45
113
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
12.1
107
501
L13
ICPC
Hip symptom/complaint
2.9
12.1
80
316
M01AB05
ATC
diclofenac; systemic, rectal
2.1
12.0
287
2096
SPAT1262
SPAT
Handing over of treatment supplies
2.5
12.0
104
481
M03BC51
ATC
orphenadrine, combinations; systemic
2.4
11.9
122
614
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
11.9
146
805
103
Kela drug reimbursment
Diabetes, insulin-treated
2.2
11.9
151
846
E66.8
ICD-10 Finland
Other obesity
5.3
11.7
35
70
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
66.8
11.7
13
*
M79.0
ICD-10 Finland
Rheumatism, unspecified
10.5
11.6
22
22
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.7
11.6
87
371
M13.9
ICD-10 Finland
Arthritis, unspecified
3.8
11.6
49
139
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
+∞
11.5
11
*
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
11.5
11
*
M43.0
ICD-10 Finland
Spondylolysis
123.2
11.5
12
*
R52.2
ICD-10 Finland
Other chronic pain
8.7
11.4
24
29
A07EC01
ATC
sulfasalazine; oral, rectal
3.8
11.3
49
142
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
13.2
11.2
19
15
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
3.0
11.2
67
246
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
11.2
135
734
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.4
11.2
40
97
C08CA01
ATC
amlodipine; oral
2.1
11.2
185
1152
S18
ICPC
Laceration/cut
2.0
11.1
197
1258
M01AX17
ATC
nimesulide; oral
2.3
11.1
123
639
SPAT1153
SPAT
Removal of sutures
2.1
11.1
155
897
J01AA02
ATC
doxycycline; systemic
2.2
11.0
340
2714
205
Kela drug reimbursment
Chronic hypertension
2.1
11.0
155
900
UJF32
NOMESCO Finland
Coloscopy
2.3
11.0
126
666
SFA10
NOMESCO Finland
Fillning on one surface of tooth
2.0
10.9
212
1405
M79.7
ICD-10 Finland
Fibromyalgia
10.0
10.9
21
22
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.1
10.8
62
222
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.3
10.8
56
187
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.1
10.6
146
835
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
10.6
170
1036
J01FF01
ATC
clindamycin; systemic
2.2
10.5
123
653
M51.8
ICD-10 Finland
Other specified intervertebral disc disorders
+∞
10.5
10
*
G55.1*M51.9
ICD-10 Finland
Nerve root and plexus compressions in intervertebral disc disorders (M50-M51+)
+∞
10.5
10
*
M01AE01
ATC
ibuprofen; systemic, rectal
2.5
10.4
376
3173
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.6
10.3
79
339
J01DA01
ATC
[U] cefalexin; systemic
1.9
10.0
264
1935
A02BC01
ATC
omeprazole; systemic
2.1
10.0
132
740
M01AX05
ATC
glucosamine; oral
2.3
10.0
109
562
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.9
10.0
225
1556
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.0
9.9
60
222
M84.1
ICD-10 Finland
Nonunion of fracture [pseudarthrosis]
20.6
9.9
14
7
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
7.1
9.7
23
34
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.6
9.7
73
310
T90
ICPC
Diabetes non-insulin dependent
2.1
9.6
126
700
N06AA10
ATC
nortriptyline; systemic
10.4
9.6
18
18
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.2
9.6
36
92
B01AB05
ATC
enoxaparin; parenteral
2.0
9.5
148
883
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
102.2
9.4
10
*
M01AC01
ATC
piroxicam; systemic, rectal
2.6
9.3
73
316
R06.0
ICD-10 Finland
Dyspnoea
2.2
9.2
109
578
SPAT1263
SPAT
Sampling
1.9
9.1
183
1199
C10AX09
ATC
ezetimibe; oral
2.7
9.1
66
273
NA2AD
NOMESCO Finland
Thoracic spine CT examination
37.5
9.1
11
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.1
9.0
117
649
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
19.1
9.0
13
7
R03AC03
ATC
terbutaline; inhalant
2.7
9.0
65
268
H02AB07
ATC
prednisone; oral
2.6
9.0
69
297
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
24.6
9.0
12
5
N02AC04
ATC
dextropropoxyphene; oral
5.4
8.9
26
51
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.7
8.9
38
109
K02.1
ICD-10 Finland
Caries of dentine
1.9
8.8
216
1516
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.1
8.8
33
85
SAA02
NOMESCO Finland
Basic examination of mouth
1.8
8.7
243
1777
C10AA07
ATC
rosuvastatin; oral
2.0
8.7
122
697
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.6
8.7
39
117
R05DA20
ATC
opium alkaloids and derivatives - combinations
2.1
8.7
115
642
J01DA08
ATC
[U] cefaclor; oral
3.3
8.6
43
140
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
3.2
8.6
44
146
R53
ICD-10 Finland
Malaise and fatigue
2.3
8.5
85
418
Z50.1
ICD-10 Finland
Other physical therapy
4.1
8.4
32
83
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
8.4
76
355
NAG66
NOMESCO Finland
Posterior interbody fusion of lumbar spine, 2 vertebrae
+∞
8.4
8
*
9211
FHL
Exploration or removal of diskusprolapse
+∞
8.4
8
*
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
+∞
8.4
8
*
J01MA02
ATC
ciprofloxacin; systemic
1.9
8.4
176
1166
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.8
8.3
191
1298
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.5
8.2
69
308
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.5
8.2
38
117
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
8.2
167
1092
R05FB02
ATC
cough suppressants and expectorants
1.9
8.2
165
1073
A06AD11
ATC
lactulose; oral
2.5
8.1
67
299
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
6.1
8.1
21
36
J01DB01
ATC
cefalexin; oral
2.0
8.1
342
2850
N04BC05
ATC
pramipexole; oral
3.1
8.0
42
143
C10AA01
ATC
simvastatin; oral
1.8
8.0
210
1493
G44.2
ICD-10 Finland
Tension-type headache
2.9
7.9
49
183
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.6
7.9
59
246
M02AA07
ATC
piroxicam; topical
1.9
7.9
162
1055
KMAK
NOMESCO Finland
NA
1.8
7.9
199
1389
N02AJ13
ATC
tramadol and paracetamol; systemic
9.7
7.8
15
16
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.6
7.8
59
251
M01AB01
ATC
indometacin; systemic, rectal
2.9
7.8
48
179
SFA00
NOMESCO Finland
Small filling
2.6
7.8
59
252
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.8
7.7
217
1565
A10BJ06
ATC
semaglutide; parenteral
4.8
7.6
24
52
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.1
7.6
95
513
M01AB55
ATC
diclofenac, combinations; oral
3.3
7.5
37
120
L17
ICPC
Foot/toe symptom/complaint
2.0
7.5
108
616
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
4.5
7.5
25
58
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
7.4
165
1102
AB5BT
NOMESCO Finland
Blockage of nerv root with X-ray guidance
81.4
7.4
8
*
NA3SA
NOMESCO Finland
Lumbar spine X-ray examination in standing position
81.4
7.4
8
*
L84
ICPC
Back syndrome without radiat pain
4.4
7.3
25
59
A46
ICD-10 Finland
Erysipelas
2.2
7.3
75
369
WX704
NOMESCO Finland
Intubation
3.3
7.3
36
117
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
4.1
7.3
27
69
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
+∞
7.3
7
*
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
+∞
7.3
7
*
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
+∞
7.3
7
*
G99.2*M47.1
ICD-10 Finland
Spondylogenic compression of spinal cord
+∞
7.3
7
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.2
7.3
79
399
L01
ICPC
Neck symptom/complaint
2.6
7.2
53
222
M01AX01
ATC
nabumetone; oral
4.2
7.2
26
65
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
7.2
55
235
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
7.2
164
1101
N06AX16
ATC
venlafaxine; oral
2.6
7.2
52
216
WX110
NOMESCO Finland
Local anesthesy
1.7
7.1
274
2157
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
6.5
7.0
17
27
M77.1
ICD-10 Finland
Lateral epicondylitis
3.5
7.0
31
93
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
3.9
7.0
27
72
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.5
6.9
23
53
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
2.9
6.9
40
145
R03BA01
ATC
beclometasone; inhalant
2.4
6.9
59
268
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
6.9
133
844
N06AX11
ATC
mirtazapine; oral
1.8
6.8
125
781
J01EA01
ATC
trimethoprim; systemic
2.0
6.8
93
522
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
40.7
6.8
8
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.1
6.7
35
119
C03CA01
ATC
furosemide; systemic
1.8
6.7
133
849
L08
ICPC
Shoulder symptom/complaint
2.1
6.7
77
399
J01FA06
ATC
roxithromycin; oral
1.8
6.7
165
1128
M53.0
ICD-10 Finland
Cervicocranial syndrome
3.7
6.6
27
76
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
12.5
6.6
11
9
E0000UV
ATC
NA
1.8
6.6
154
1037
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.6
6.6
48
199
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.3
6.5
31
99
M03BB52
ATC
chlormezanone, combinations excl. psycholeptics; oral, rectal
7.6
6.5
14
19
SPAT1058
SPAT
PEF monitoring instruction
2.8
6.4
39
147
P01BA02
ATC
hydroxychloroquine; oral
2.8
6.4
41
158
N06AB04
ATC
citalopram; systemic
2.0
6.4
88
491
M01AE52
ATC
naproxen and esomeprazole; oral
4.7
6.4
20
44
M19.8
ICD-10 Finland
Other specified arthrosis
4.5
6.3
21
49
M01AH03
ATC
valdecoxib; oral
3.0
6.3
34
119
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
+∞
6.3
6
*
NAG65
NOMESCO Finland
Anterior and posterior fusion of lumbar spine
+∞
6.3
6
*
72880
ICD-8 Finland
Vertebrogenic pain syndrome, Radicula syndrome of lower limbs
+∞
6.3
6
*
72510
ICD-8 Finland
Displacement of intervertebral disk, Lumbalis cum prolapsu disci
+∞
6.3
6
*
L85
ICPC
Acquired deformity of spine
+∞
6.3
6
*
M53.2
ICD-10 Finland
Spinal instabilities
+∞
6.3
6
*
SPAT1216
SPAT
Assessment of functional ability
2.1
6.2
70
359
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
3.8
6.2
24
65
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.9
6.2
36
132
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.5
6.2
27
81
M15.8
ICD-10 Finland
Other polyarthrosis
7.8
6.2
13
17
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.0
6.2
35
125
A01
ICPC
Pain general/multiple sites
2.9
6.1
35
126
H02AB09
ATC
hydrocortisone; systemic
6.8
6.1
14
21
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
4.4
6.0
20
47
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
382
2695
3.17
22.75
5.5
3.8
13.9
12.8
mm/h
0.66
362
2447
320
2227
2.35
16.67
5.1
4.7
7.1
6.8
mmol/l
1.01
298
2096
116
532
2.56
15.85
1.3
1.2
17.2
38.6
iu/ml
2.46
29
158
303
2099
2.23
15.40
8.6
9.9
4.2
4.1
e9/l
0.34
274
1840
108
493
2.54
14.82
1.4
1.2
9.4
14.6
u/ml
0.40
42
192
140
726
2.32
14.44
5.7
3.5
1.0
1.0
kg/l
0.36
22
109
247
1621
2.10
13.90
5.1
4.9
36.0
35.2
g/l
1.52
232
1508
376
2910
2.42
13.78
8.6
7.7
80.0
79.5
u/l
0.09
364
2715
439
3697
3.61
13.08
20.7
14.1
20.7
26.6
mg/l
4.07
384
2906
259
1764
2.03
12.80
4.8
3.3
0.0
0.0
estimate
0.50
34
325
247
1688
1.97
11.73
4.9
3.8
—
—
—
0
0
183
1128
2.02
11.70
2.3
2.1
227.9
304.9
u/l
0.43
167
1055
252
1748
1.95
11.31
6.3
4.5
0.0
0.0
estimate
0.00
39
342
168
1015
2.02
11.28
2.7
2.7
8617.1
7077.2
umol/l
0.14
154
881
101
508
2.26
10.89
29.4
23.2
1.1
1.3
inr
3.62
14
77
250
1745
1.92
10.85
4.9
3.3
0.0
0.0
estimate
0.00
39
334
208
1375
1.92
10.58
5.3
3.4
—
—
—
0
0
276
2003
1.91
10.50
6.1
6.8
10.8
12.4
umol/l
1.54
260
1899
216
1466
1.87
9.96
4.3
3.5
26.4
50.2
ng/l
2.78
156
1096
200
1329
1.87
9.82
4.2
4.1
7.2
8.1
mg/mmol
0.15
151
857
313
2396
1.91
9.79
5.9
4.0
22.3
3538.7
e6/l
—
6
44
213
1448
1.86
9.70
3.5
2.6
156.6
156.6
ug/l
0.00
198
1308
342
2714
1.94
9.35
4.6
3.6
15.2
14.9
pmol/l
1.19
322
2420
209
1425
1.84
9.33
2.7
2.2
72.9
76.9
nmol/l
1.54
193
1256
220
1543
1.80
8.80
2.3
2.0
92.9
95.6
pmol/l
0.33
130
815
400
3395
2.15
8.48
5.6
4.3
1.8
2.0
mu/l
2.46
376
3028
421
3656
2.38
8.28
8.6
6.0
42.6
40.4
mmol/mol
4.28
402
3354
106
602
1.98
8.14
1.8
1.9
—
—
—
0
0
61
283
2.33
7.85
2.9
2.7
62.2
59.0
ml/min/173m2
0.23
25
106
250
1864
1.72
7.74
8.0
6.9
1.2
1.2
mmol/l
0.17
225
1556
102
583
1.96
7.66
2.9
2.4
12.2
13.0
umol/l
0.57
95
538
186
1282
1.74
7.61
3.4
3.2
8.0
7.9
mmol/l
0.21
162
1060
173
1172
1.75
7.50
3.1
3.1
952.4
1383.4
ng/l
1.44
154
1013
78
410
2.08
7.37
1.8
1.8
—
—
—
0
0
81
432
2.06
7.37
4.9
7.8
2.1
1.2
mmol/l
1.67
63
347
445
4017
2.82
7.09
24.0
16.4
139.8
139.7
mmol/l
0.48
438
3895
446
4031
2.86
7.08
24.1
16.6
4.0
4.0
mmol/l
0.83
439
3903
89
498
1.97
7.07
4.8
7.2
103.8
104.3
mmol/l
0.48
89
481
77
409
2.05
7.07
1.8
1.8
—
—
—
0
0
118
732
1.82
6.81
1.8
1.7
1.4
1.4
mg/l
0.01
90
573
145
956
1.75
6.80
5.8
3.4
0.0
0.0
estimate
0.50
38
329
172
1208
1.67
6.31
3.7
3.3
34.1
47.3
u/l
0.49
166
1151
88
511
1.89
6.23
2.8
2.5
18.9
23.0
%
2.18
74
444
138
918
1.71
6.19
2.8
2.0
3.1
3.1
mg/l
0.01
124
778
91
539
1.85
6.04
3.0
2.5
2.3
2.3
g/l
0.73
82
498
26
90
3.00
5.98
1.4
1.1
—
—
—
0
0
112
709
1.76
5.97
4.3
3.6
303.6
422.9
ng/l
0.37
90
579
26
92
2.93
5.77
1.4
1.1
—
—
—
0
0
29
110
2.74
5.68
1.0
1.1
—
—
u/ml
—
0
0
444
4082
2.43
5.36
14.0
10.4
27.7
26.6
u/l
0.80
435
3914
27
102
2.75
5.34
1.7
1.3
—
—
—
0
0
220
1691
1.56
5.33
6.6
6.0
1.2
1.2
mmol/l
0.86
203
1527
169
1228
1.59
5.20
3.0
3.7
2.4
2.4
mmol/l
0.04
152
1076
71
407
1.88
5.20
1.4
1.3
—
—
—
0
0
23
81
2.93
5.16
1.0
1.1
—
8.4
—
0
13
105
687
1.68
4.89
1.9
1.7
1134.0
1122.5
nmol/l
0.05
92
520
26
101
2.67
4.89
1.4
1.5
0.0
0.0
iu/ml
—
6
14
61
340
1.91
4.86
4.0
3.8
3.4
1.9
mmol/l
1.86
51
266
32
139
2.40
4.80
1.5
1.3
—
—
—
0
0
418
3787
1.89
4.80
6.2
4.7
6.3
6.1
mmol/l
3.10
393
3404
103
678
1.66
4.68
1.4
1.2
4.0
1.2
u/ml
0.54
25
187
118
809
1.61
4.55
2.0
1.7
104673284.5
6163742.7
pmol/l
0.71
107
649
36
171
2.20
4.41
4.1
2.6
1.2
1.2
%
0.14
36
171
356
3121
1.57
4.27
23.3
17.6
14.0
13.7
%
1.81
349
3047
52
290
1.89
4.15
4.3
3.0
4.6
4.6
kpa
0.05
52
279
182
1400
1.49
4.11
4.3
3.1
—
—
—
0
0
288
2441
1.46
3.85
3.6
3.0
53.1
57.7
u/l
0.55
272
2259
46
254
1.90
3.79
2.0
1.6
—
—
—
0
0
425
3928
1.81
3.76
6.5
5.1
2.6
2.7
mmol/l
1.91
406
3568
71
452
1.67
3.63
11.6
6.3
—
—
—
0
0
98
685
1.54
3.41
3.0
3.3
2.4
2.5
mmol/l
0.54
86
616
123
910
1.48
3.26
1.7
1.5
19.4
21.2
nmol/l
0.70
115
757
233
1937
1.40
3.24
2.5
2.4
—
—
—
0
0
121
895
1.47
3.21
2.7
2.4
—
—
—
0
0
23
106
2.23
3.08
1.7
1.5
—
—
—
0
0
10
30
3.38
2.92
1.5
1.8
—
—
—
0
0
414
3853
1.60
2.88
6.0
4.5
4.4
4.6
mmol/l
2.37
393
3526
10
31
3.27
2.78
2.7
2.6
—
—
—
0
0
12
42
2.91
2.77
1.0
1.3
57.7
48.1
u/l
—
6
27
411
3828
1.56
2.74
5.7
4.5
1.4
1.4
mmol/l
3.64
388
3475
65
439
1.56
2.63
3.3
2.7
8.2
9.5
umol/l
0.28
57
391
36
210
1.77
2.55
1.7
1.4
—
—
—
0
0
36
211
1.76
2.51
2.1
2.5
—
14.5
—
0
10
20
96
2.13
2.46
1.4
1.3
—
—
—
0
0
23
117
2.02
2.45
1.9
2.5
102.4
68.4
ug/min
0.20
14
71
18
83
2.21
2.44
3.1
2.7
17.2
16.4
%
0.33
12
46
398
3705
1.47
2.42
5.3
4.1
1.4
1.3
mmol/l
3.42
377
3347
14
58
2.46
2.39
1.4
1.9
—
—
—
0
0
16
71
2.30
2.37
1.2
1.4
—
—
—
0
0
42
262
1.66
2.36
4.3
4.0
108.2
87.4
ng/l
0.73
37
224
14
61
2.33
2.16
1.4
1.8
—
—
—
0
0
8
25
3.24
2.10
1.6
2.0
—
—
—
0
0
6
15
4.04
2.04
1.2
1.5
—
—
—
0
0
8
26
3.11
2.02
1.6
1.9
—
—
—
0
0
14
64
2.22
1.96
1.4
1.8
—
—
—
0
0
37
236
1.62
1.94
2.6
4.2
3.2
2.1
mmol/l
0.74
24
183
19
99
1.96
1.93
1.5
1.4
261.3
294.1
ug/g
0.36
14
59
174
1470
1.29
1.90
4.9
4.0
19.7
21.5
%
1.18
87
725
15
72
2.12
1.88
1.1
1.2
—
—
—
0
0
211
1829
1.28
1.87
5.4
4.7
2.2
2.5
ug/l
0.36
193
1625
18
93
1.97
1.87
2.8
3.2
8.1
8.0
kpa
0.10
18
84
46
312
1.53
1.87
3.8
2.7
67.9
66.5
g/l
0.60
41
286
365
3396
1.33
1.83
21.0
15.2
38.1
40.2
%
1.97
224
2332
21
116
1.85
1.81
1.9
1.6
—
—
—
0
0
84
645
1.37
1.78
3.2
2.8
0.8
1.2
e6/l
1.53
55
373
25
149
1.72
1.70
1.2
1.5
—
—
—
0
0
14
70
2.03
1.60
1.4
1.9
—
—
—
0
0
6
20
3.02
1.58
1.3
1.8
—
—
—
0
0
6
20
3.02
1.58
1.3
1.8
—
—
—
0
0
128
1062
1.28
1.58
4.2
3.1
0.3
0.5
e6/l
1.37
102
801
392
3713
1.33
1.52
17.4
13.5
77.8
78.1
ml/min/173m2
0.09
347
3083
7
27
2.62
1.52
1.1
1.3
—
—
—
0
0
46
328
1.45
1.50
2.8
2.1
14.6
13.5
nmol/l
0.31
38
297
18
299
0.59
1.43
1.8
1.8
—
—
—
0
0
26
168
1.58
1.34
1.2
1.6
—
—
—
0
0
12
61
1.99
1.34
1.8
1.3
—
—
—
0
0
12
61
1.99
1.34
1.8
1.3
—
—
—
0
0
9
43
2.11
1.31
1.1
2.0
—
—
—
0
0
6
24
2.52
1.30
2.2
3.8
—
—
—
0
0
5
18
2.80
1.29
1.0
1.0
—
—
—
0
0
23
146
1.60
1.28
1.5
1.8
—
—
—
0
0
11
55
2.02
1.28
1.6
2.5
3.9
4.0
mmol/l
0.33
11
55
11
55
2.02
1.28
1.6
2.5
106.7
105.0
mmol/l
0.52
11
55
8
36
2.24
1.25
1.0
1.1
2.1
1.5
nmol/l
—
8
31
8
36
2.24
1.25
1.5
1.9
—
—
—
0
0
125
1063
1.24
1.24
1.9
1.6
1.5
1.4
mmol/l
0.96
109
863
11
56
1.99
1.23
1.3
1.4
—
—
—
0
0
5
19
2.65
1.22
1.4
1.8
—
—
—
0
0
5
19
2.65
1.22
1.4
1.8
—
—
—
0
0
77
621
1.29
1.19
3.4
2.9
1.6
1.8
e6/l
0.18
49
353
10
50
2.02
1.17
1.4
2.0
—
—
—
0
0
12
65
1.87
1.14
1.4
1.8
—
—
—
0
0
8
41
1.97
1.09
1.0
1.1
—
—
—
0
0
26
179
1.48
1.05
1.1
1.2
206.4
134.0
iu/ml
—
9
74
9
47
1.93
1.02
1.7
1.7
—
—
—
0
0
9
47
1.93
1.02
1.7
1.7
—
—
—
0
0
9
47
1.93
1.02
1.7
1.7
—
—
—
0
0
9
48
1.89
1.01
1.7
1.7
—
—
—
0
0
9
48
1.89
1.01
1.7
1.7
—
—
—
0
0
9
48
1.89
1.01
1.7
1.7
—
—
—
0
0
15
92
1.65
0.98
1.5
2.1
—
—
—
0
0
23
157
1.49
0.98
1.8
1.9
—
—
—
0
0
11
62
1.79
0.95
2.9
2.5
3.4
4.3
e9/l
1.04
11
62
13
80
1.64
0.85
1.4
1.9
—
—
—
0
0
6
32
1.89
0.82
1.5
1.3
—
—
—
0
0
8
47
1.71
0.81
1.8
1.6
—
—
—
0
0
10
58
1.74
0.80
1.2
1.9
—
—
—
0
0
5
25
2.01
0.73
1.0
7.0
—
40.0
—
0
6
5
25
2.01
0.73
1.2
1.4
—
74.3
—
0
7
11
68
1.63
0.72
2.9
2.9
51.3
56.8
%
0.88
11
68
43
349
1.26
0.68
2.4
2.2
40.7
43.4
u/l
0.06
38
307
14
95
1.49
0.64
5.1
4.0
16.0
34.0
mg/l
—
8
60
32
254
1.28
0.61
1.6
1.6
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
18
132
1.38
0.58
2.3
2.8
0.2
0.4
u/ml
—
10
71
6
35
1.72
0.58
1.2
1.1
—
—
—
0
0
50
423
1.20
0.56
4.0
3.0
—
—
—
0
0
12
82
1.48
0.55
1.8
1.6
—
—
—
0
0
6
39
1.55
0.53
1.3
2.9
3.9
3.9
nmol/l
—
6
39
6
40
1.51
0.51
1.0
1.3
208.5
319.7
pmol/l
—
6
35
13
92
1.42
0.51
1.5
1.8
—
—
—
0
0
10
67
1.50
0.50
1.0
1.2
2.0
58.2
e6/l
—
10
54
10
67
1.50
0.50
1.1
1.3
130.4
163.5
e6/l
—
10
55
5
81
0.61
0.46
1.2
1.3
—
—
—
0
0
14
103
1.37
0.45
1.4
1.8
—
—
—
0
0
19
148
1.30
0.44
2.4
3.1
—
—
—
0
0
14
105
1.34
0.41
1.4
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
9
69
1.31
0.37
1.3
1.0
—
—
—
0
0
5
37
1.36
0.37
5.8
3.8
—
—
—
0
0
10
72
1.40
0.37
1.1
1.1
—
—
—
0
0
11
81
1.37
0.36
1.6
1.5
—
—
—
0
0
6
42
1.43
0.35
1.3
2.0
—
—
—
0
0
11
84
1.32
0.30
1.3
1.3
—
—
—
0
0
13
102
1.28
0.30
1.5
1.5
—
—
—
0
0
18
148
1.22
0.29
2.9
1.9
—
—
—
0
0
7
57
1.23
0.29
1.3
1.1
118.0
111.8
%
—
7
52
47
520
0.89
0.27
5.0
4.6
30.1
31.4
%
0.40
39
337
9
72
1.25
0.25
1.4
1.3
—
—
—
0
0
11
87
1.27
0.24
3.7
7.0
—
252.5
—
0
11
114
1086
1.07
0.21
3.1
2.9
0.6
0.8
ug/l
3.24
79
741
0
11
0.00
0.21
0.0
2.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
1489.4
—
0
13
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
14
117
1.20
0.20
2.5
2.5
3.4
3.8
g/l
0.44
14
109
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
12
100
1.21
0.18
1.2
2.2
16.1
12.7
mg/l
0.69
12
91
18
157
1.15
0.17
1.6
2.1
41.2
38.0
u/l
0.28
18
138
13
111
1.18
0.16
1.5
1.7
—
—
—
0
0
17
149
1.15
0.16
1.0
1.0
—
—
—
0
0
48
459
1.05
0.09
4.0
4.8
5.7
33.7
ug/l
0.98
39
387
6
54
1.11
0.09
1.3
1.1
—
—
—
0
0
6
55
1.09
0.09
1.0
1.2
—
—
—
0
0
37
351
1.06
0.09
1.5
1.4
—
—
—
0
0
5
60
0.83
0.08
1.0
1.1
—
—
—
0
0
8
91
0.88
0.07
1.0
1.3
—
—
—
0
0
13
124
1.05
0.00
2.2
2.2
95.6
88.1
%
0.63
13
116
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
60
1.00
0.00
1.0
1.1
1.6
1.5
g/l
—
6
55
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
12
120
1.00
0.00
2.2
1.6
35.8
40.9
nmol/l
0.82
12
115
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
22.2
—
0
5
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_FORESTIER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FORESTIER | 1.208 [1.03, 1.42] | 0.021 |
| Birth year | 0.99 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 210 out of 1048 females with M13_FORESTIER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FORESTIER | 1.194 [1.04, 1.37] | 0.012 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 338 out of 1527 males with M13_FORESTIER died.
Mortality risk
Mortality risk for people of age
years, who have M13_FORESTIER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.213% |
| 5 | 0.511% | 1.204% |
| 10 | 1.405% | 3.308% |
| 15 | 2.672% | 6.12% |
| 20 | 4.768% | 10.485% |
Relationships between endpoints
↥Index endpoint: M13_FORESTIER – Ankylosing hyperostosis [Forestier]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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