No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
767 |
4. Check minimum number of eventsNone |
767 |
5. Include endpointsNone |
767 |
6. Filter based on genotype QC (FinnGen only) |
737 |
Control definitions (FinnGen only)
- Control exclude
- AB1_SEQULEAE_OF_INFECTIONS_AND_PARASITES
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Sequelae of tuberculosis
based on the number of shared cases.
Similar with more cases:
- Sequelae of infectious and parasitic diseases
- Certain infectious and parasitic diseases
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12957 | 5086 | 7338 |
| Only index persons | 5957 | 2950 | 3007 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.15 | 0.21 |
| Only index persons | 0.11 | 0.11 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 67.14 | 68.05 | 66.71 |
| Only index persons | 66.85 | 67.27 | 66.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 737 | 273 | 464 |
| Unadjusted period prevalence (%) | 0.17 | 0.10 | 0.21 |
| Median age at first event (years) | 66.41 | 63.21 | 68.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 766
- Matched controls
- 7660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
13954.8
307.7
524
*
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
59.2
97.6
55
10
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
4.1
77.6
317
1119
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
+∞
75.3
71
*
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
37.9
69.0
43
12
J96.1
ICD-10 Finland
Chronic respiratory failure
8.1
62.7
89
122
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.5
56.8
166
448
J47
ICD-10 Finland
Bronchiectasis
9.5
53.9
66
75
1370X
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,MUU JÄLKITILA]
+∞
53.8
51
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.5
52.9
249
931
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.6
51.9
225
797
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.9
51.8
187
586
01908
ICD-8 Finland
Late effects of tuberculosis, Sequelae aliae o tuberculosis organorum respirationis
+∞
51.6
49
*
B90.0
ICD-10 Finland
Sequelae of central nervous system tuberculosis
+∞
50.6
48
*
R03BB01
ATC
ipratropium bromide; inhalant
4.1
44.5
141
400
R03DA04
ATC
theophylline; systemic, rectal
3.7
44.1
166
531
R03AC02
ATC
salbutamol; inhalant
2.8
41.8
451
2597
R03BB04
ATC
tiotropium bromide; inhalant
3.3
39.9
191
708
R03AK03
ATC
[U] fenoterol and ipratropium bromide
3.4
38.1
161
552
J45.9
ICD-10 Finland
Asthma, unspecified
3.0
35.9
208
856
B90.2
ICD-10 Finland
Sequelae of tuberculosis of bones and joints
+∞
35.7
34
*
J45.1
ICD-10 Finland
Nonallergic asthma
4.1
34.4
105
288
R03AC12
ATC
salmeterol; inhalant
3.9
33.1
108
310
R03BA01
ATC
beclometasone; inhalant
3.0
32.4
173
677
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.9
30.7
184
764
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
28.0
377
2267
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
64.5
27.1
31
5
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
6.8
27.1
43
66
R03BA05
ATC
fluticasone; inhalant
2.7
26.4
171
735
H02AB06
ATC
prednisolone; systemic
2.2
26.1
416
2656
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
22.8
25.9
37
17
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.3
25.7
105
348
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
5.7
25.5
49
91
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.3
25.1
69
174
R04.2
ICD-10 Finland
Haemoptysis
4.0
22.1
66
177
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.6
21.3
74
220
R03BA02
ATC
budesonide; inhalant
2.4
20.9
166
780
4912A
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS CHRONICA OBSTRUCTIVA]
7.2
20.1
30
43
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.8
19.0
102
394
J45.8
ICD-10 Finland
Mixed asthma
4.7
18.4
44
99
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
5.5
18.4
36
68
R03AC13
ATC
formoterol; inhalant
3.3
17.9
71
230
TGC00
NOMESCO Finland
Bronchial lavation
5.0
17.5
38
79
01904
ICD-8 Finland
Late effects of tuberculosis, Adhaesiones pleurae
+∞
16.7
16
*
J01AA02
ATC
doxycycline; systemic
2.1
16.6
578
4578
H02AB04
ATC
methylprednisolone; systemic
2.3
16.4
139
666
R03AK07
ATC
formoterol and budesonide; inhalant
2.3
15.8
137
663
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.0
14.9
69
245
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
21.5
14.7
21
10
01909
ICD-8 Finland
Late effects of tuberculosis, Sequelae NUD o tuberculosis organorum respirationis
+∞
14.6
14
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
14.4
174
958
R03DC03
ATC
montelukast; oral
2.4
14.3
109
497
R03AC03
ATC
terbutaline; inhalant
2.3
14.3
115
538
R03BB02
ATC
oxitropium bromide; inhalant
4.8
13.6
31
67
B90.1
ICD-10 Finland
Sequelae of genitourinary tuberculosis
+∞
13.6
13
*
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
40.8
13.2
16
*
J01FA06
ATC
roxithromycin; oral
1.8
13.1
309
2103
B90.8
ICD-10 Finland
Sequelae of tuberculosis of other organs
+∞
12.5
12
*
49300
ICD-8 Finland
Asthma, bronchiale
3.8
12.5
39
108
XG410
NOMESCO Finland
Flow-volume spirometry
3.4
12.4
45
138
J01MA14
ATC
moxifloxacin; systemic
2.4
12.2
91
410
R06.0
ICD-10 Finland
Dyspnoea
1.8
12.1
241
1554
01930
ICD-8 Finland
Late effects of tuberculosis, Columnae vertebralis
+∞
11.5
11
*
01901
ICD-8 Finland
Late effects of tuberculosis, Emphysema
+∞
11.5
11
*
R95
ICPC
Chron obstructive pulmonary disease
3.3
10.8
41
129
R05CB01
ATC
acetylcysteine; inhalant, oral
3.5
10.8
37
109
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
111.5
10.4
11
*
A15.3
ICD-10 Finland
Tuberculosis of lung, confirmed by unspecified means
+∞
10.4
10
*
1373X
ICD-9 Finland
Late effects of tuberculosis of bones and joints
+∞
10.4
10
*
1370D
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,PLEURAFIBROOSI]
+∞
10.4
10
*
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
12.3
10.4
18
15
7863A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Haemoptysis
9.7
10.3
20
21
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
23.7
10.3
14
6
J01MA12
ATC
levofloxacin; systemic
1.8
10.1
177
1090
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
5.1
10.1
21
42
01210
ICD-8 Finland
Other respiratory tuberculosis, Tuberculosis pleurae, pleuritis exsudativa tuberculosa
40.6
10.0
12
*
H02AB07
ATC
prednisone; oral
1.9
9.9
139
797
78310
ICD-8 Finland
Symptoms referable to respiratory system, Haemoptysis
10.2
9.6
18
18
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.9
9.6
46
167
R03AK08
ATC
formoterol and beclometasone; inhalant
3.4
9.5
34
103
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.7
9.5
30
84
01903
ICD-8 Finland
Late effects of tuberculosis, Fibrosis pulmonum
+∞
9.4
9
*
01106
ICD-8 Finland
Pulmonary tuberculosis, Pulmonum alia sive NUD
+∞
9.4
9
*
1240
FHL
Bronchoscopy
3.5
9.1
31
91
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
50.6
8.7
10
*
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
3.4
8.6
30
90
01931
ICD-8 Finland
Late effects of tuberculosis, Coxae
+∞
8.3
8
*
01900
ICD-8 Finland
Late effects of tuberculosis, Bronchiectasia
+∞
8.3
8
*
01510
ICD-8 Finland
Tuberculosis of bones and joints, Of hip
+∞
8.3
8
*
J46
ICD-10 Finland
Status asthmaticus
3.4
8.3
30
92
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
15.2
7.7
12
8
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
2.9
7.5
35
125
0110K, ,
ICD-8 Finland
80.9
7.4
8
*
01220
ICD-8 Finland
Other respiratory tuberculosis, Pleurisy with effusion without mention of cause
11.0
7.3
13
12
1370C
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,BRONKIEKTASIAT]
+∞
7.3
7
*
R05
ICD-10 Finland
Cough
1.8
7.2
122
740
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
7.1
138
869
R96
ICPC
Asthma
2.1
6.9
66
329
R02
ICPC
Shortness of breath/dyspnoea
1.8
6.9
101
586
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
3.8
6.8
20
53
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
6.8
280
2108
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
3.0
6.8
30
104
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
9.4
6.8
13
14
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
40.4
6.8
8
*
Y3429
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Other inactive tuberculosis cases
40.4
6.8
8
*
R03BA08
ATC
ciclesonide; inhalant
2.3
6.7
49
220
J96.0
ICD-10 Finland
Acute respiratory failure
3.4
6.6
23
69
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
6.3
6.5
16
26
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
70.4
6.4
7
*
51899
ICD-8 Finland
Bronchiectasis
11.1
6.3
11
10
Z02.4
ICD-10 Finland
Examination for driving licence
0.6
6.3
89
1461
J42
ICD-10 Finland
Unspecified chronic bronchitis
3.9
6.3
18
47
1374X
ICD-9 Finland
Late effects of tuberculosis of other specified organs
+∞
6.3
6
*
L04AA13
ATC
[U] leflunomide
3.7
6.2
19
52
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.3
6.2
45
201
C03CA01
ATC
furosemide; systemic
1.5
6.2
390
3180
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
4.0
6.2
17
43
48509
ICD-8 Finland
Bronchopneumonia, unspecified
7.8
6.1
13
17
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
8.7
6.1
12
14
J01FA10
ATC
azithromycin; systemic
1.5
6.1
270
2056
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
108
215
5.68
52.93
5.0
2.8
—
—
—
0
0
38
67
5.92
20.88
6.4
3.5
—
—
—
0
0
49
136
3.78
15.59
2.3
1.3
—
—
—
0
0
38
116
3.39
10.53
1.5
1.5
34.98
35.45
iu/ml
0.00
14
34
25
73
3.51
7.45
1.1
1.2
—
—
—
0
0
19
32
6.06
7.41
5.6
4.9
—
—
—
0
0
23
71
3.31
6.32
1.4
1.5
—
—
—
0
0
23
71
3.31
6.32
1.4
1.5
—
—
—
0
0
17
46
3.76
5.67
1.2
1.4
—
—
—
0
0
17
46
3.76
5.67
1.2
1.4
—
—
—
0
0
25
89
2.87
5.45
1.3
1.5
—
—
—
0
0
109
699
1.65
5.19
5.0
5.9
5.53
5.02
kpa
3.39
104
657
107
696
1.62
4.81
5.0
5.9
2.94
1.35
mmol/l
3.31
93
532
29
120
2.47
4.77
1.5
1.5
—
—
—
0
0
267
2123
1.40
4.46
9.0
5.1
60.69
59.77
%
0.57
249
1947
270
2159
1.39
4.33
9.2
5.3
23.68
24.77
%
0.89
251
1976
50
274
1.88
4.11
1.8
1.8
1.00
2.85
ug/l
0.88
42
223
20
77
2.64
3.83
1.4
1.4
—
—
—
0
0
350
4050
0.75
3.76
4.3
4.5
4.25
4.33
mmol/l
0.75
316
3562
26
115
2.31
3.75
1.4
1.5
—
—
—
0
0
344
3989
0.75
3.75
4.4
4.5
1.44
1.44
mmol/l
0.07
309
3467
20
80
2.54
3.57
1.4
1.5
—
—
—
0
0
253
2058
1.34
3.50
3.9
3.3
2059.45
2375.93
ng/l
0.49
227
1769
313
2631
1.32
3.44
11.2
7.7
4.58
4.47
e9/l
0.32
286
2264
334
3858
0.76
3.38
4.0
4.0
1.19
1.23
mmol/l
0.54
295
3311
360
4114
0.76
3.35
7.1
6.5
41.81
41.75
mmol/mol
0.04
325
3664
120
868
1.45
3.33
3.2
2.4
2.30
2.23
g/l
0.76
112
782
18
71
2.57
3.31
1.4
1.5
—
—
—
0
0
13
39
3.37
3.23
1.2
1.6
—
—
—
0
0
141
1063
1.40
3.11
2.2
1.8
—
—
—
0
0
128
952
1.41
3.05
3.2
2.4
11.14
11.51
umol/l
0.26
118
863
373
4204
0.78
2.92
4.8
5.1
2.39
2.46
mmol/l
0.82
337
3666
7
13
5.42
2.87
2.4
1.2
—
—
—
0
0
112
827
1.41
2.78
3.4
2.4
20.26
21.10
%
0.23
89
699
5
6
8.38
2.75
1.0
1.7
—
—
—
0
0
103
753
1.43
2.71
2.1
1.8
—
—
—
0
0
29
154
1.92
2.69
2.3
1.5
—
—
—
0
0
72
496
1.50
2.57
7.8
5.8
11.74
12.59
mmol/l
0.40
61
462
439
4807
0.80
2.46
39.0
27.5
127.11
129.17
g/l
2.12
427
4658
439
4806
0.80
2.45
38.8
27.3
4.23
4.28
e12/l
1.16
424
4597
439
4806
0.80
2.45
38.5
27.4
37.93
38.25
%
0.38
391
4352
439
4805
0.80
2.44
39.2
27.3
243.61
234.64
e9/l
1.99
426
4616
26
138
1.92
2.44
1.4
1.4
—
—
—
0
0
11
38
2.92
2.42
1.3
1.6
—
—
—
0
0
100
744
1.40
2.39
2.1
1.8
—
—
—
0
0
53
353
1.54
2.24
4.5
4.0
2.62
1.97
mmol/l
0.52
41
262
33
196
1.71
2.19
3.2
3.3
63.72
90.98
mg/l
0.37
27
160
435
4740
0.81
2.19
31.3
23.0
4.03
4.03
mmol/l
0.16
424
4557
33
197
1.71
2.15
3.2
3.4
36.03
40.90
mg/l
0.23
27
162
6
14
4.31
2.15
1.2
1.1
—
—
—
0
0
435
4734
0.81
2.13
30.8
22.9
139.05
139.47
mmol/l
2.19
425
4555
75
544
1.42
2.09
5.7
6.7
120.65
118.80
g/l
0.35
75
530
11
44
2.52
2.02
1.5
1.5
—
—
—
0
0
11
44
2.52
2.02
1.5
1.5
—
—
—
0
0
11
44
2.52
2.02
1.5
1.5
—
—
—
0
0
5
11
4.57
1.94
1.0
1.2
—
—
—
0
0
97
745
1.35
1.93
6.6
4.6
1.07
1.04
mmol/l
0.57
86
664
425
4614
0.82
1.93
13.9
10.7
21.29
22.66
u/l
1.47
406
4357
68
920
0.71
1.92
4.5
3.3
3.18
2.54
e6/l
0.19
39
538
106
827
1.33
1.90
4.0
2.8
0.80
0.81
mmol/l
0.56
97
757
0
50
0.00
1.89
0.0
1.5
—
—
—
0
0
23
129
1.81
1.87
5.0
5.0
101.83
104.85
mmol/l
1.75
23
117
71
948
0.72
1.85
4.3
3.1
1.86
1.28
e6/l
0.35
42
561
15
73
2.08
1.81
1.5
1.6
—
—
—
0
0
7
23
3.06
1.80
4.1
3.2
224.43
238.17
u/l
—
7
23
182
1544
1.23
1.68
2.6
2.4
64.92
59.51
u/l
0.29
171
1417
372
4058
0.84
1.66
23.9
18.4
69.66
67.28
ml/min/173m2
1.25
303
3360
38
253
1.53
1.66
1.9
1.9
—
—
—
0
0
161
1352
1.24
1.63
2.8
2.8
29.93
35.19
u/l
1.11
153
1277
78
1005
0.75
1.62
1.6
1.6
1.22
1.24
mmol/l
0.10
66
811
70
529
1.36
1.58
3.2
2.4
66.36
65.35
g/l
0.45
61
461
44
306
1.46
1.58
5.2
7.9
26.17
24.51
mmol/l
2.45
39
288
10
44
2.29
1.56
1.2
1.0
—
—
u/ml
—
0
0
374
4063
0.84
1.55
5.0
4.6
2.01
2.07
mu/l
0.38
343
3528
5
15
3.35
1.52
1.6
1.5
0.32
0.11
nmol/l
—
5
9
393
4247
0.85
1.51
4.9
5.0
6.09
6.17
mmol/l
0.54
347
3668
96
1189
0.78
1.49
2.7
3.2
2.47
2.47
mmol/l
0.01
81
1021
10
45
2.24
1.47
1.8
1.4
—
—
—
0
0
9
38
2.38
1.46
1.4
1.3
—
—
—
0
0
9
38
2.38
1.46
1.4
1.3
—
—
—
0
0
5
16
3.14
1.44
1.0
1.1
—
—
—
0
0
16
89
1.81
1.38
1.5
1.6
—
—
—
0
0
72
560
1.32
1.36
1.3
1.2
17.71
10.20
u/ml
0.34
32
186
25
159
1.59
1.36
1.4
1.4
—
—
—
0
0
25
159
1.59
1.36
1.4
1.4
—
—
—
0
0
33
225
1.49
1.33
1.7
1.7
—
—
—
0
0
5
18
2.79
1.28
2.6
1.7
—
—
—
0
0
5
18
2.79
1.28
1.0
1.1
—
—
—
0
0
5
18
2.79
1.28
1.0
1.2
—
—
—
0
0
12
62
1.95
1.28
1.4
1.4
—
—
—
0
0
6
25
2.41
1.24
1.8
1.5
—
—
—
0
0
6
25
2.41
1.24
1.8
1.5
—
—
—
0
0
19
116
1.65
1.22
1.2
1.7
9007.50
18034.34
e6/l
0.70
12
76
5
19
2.64
1.21
2.0
1.6
—
—
—
0
0
5
19
2.64
1.21
2.0
1.6
—
—
—
0
0
86
1051
0.80
1.21
3.4
3.3
0.78
0.89
ug/l
0.65
62
750
15
86
1.76
1.19
3.3
3.5
61.47
62.58
%
0.13
15
86
76
610
1.27
1.16
4.8
3.3
270.64
309.16
ng/l
0.41
69
558
427
4534
0.87
1.15
28.5
18.9
29.38
28.89
mg/l
0.11
383
3811
22
142
1.57
1.15
6.6
4.6
5.15
5.07
kpa
0.16
22
137
5
20
2.51
1.15
2.8
1.6
—
—
—
0
0
302
3280
0.87
1.12
4.2
3.7
15.59
15.21
pmol/l
1.67
275
2821
43
320
1.36
1.12
1.9
1.7
1.37
1.52
g/l
0.45
37
284
154
1760
0.84
1.11
4.4
3.6
23.65
131.39
e6/l
2.24
133
1396
138
1591
0.84
1.10
4.6
3.5
0.55
0.51
e6/l
0.07
119
1254
169
1912
0.85
1.08
4.7
5.5
3.30
6.50
ug/l
0.70
149
1642
7
33
2.13
1.05
3.1
3.5
—
—
—
0
0
5
22
2.28
1.03
1.0
3.3
63.00
122.59
nmol/l
—
5
22
57
449
1.29
1.03
3.0
3.7
92.90
96.20
ng/l
0.11
42
379
9
47
1.93
1.02
1.2
1.4
0.51
0.58
nmol/l
—
9
42
51
649
0.77
1.02
13.1
9.9
—
—
—
0
0
14
83
1.70
1.02
2.9
3.0
4.99
4.75
e9/l
0.10
14
83
10
53
1.90
1.01
1.9
1.5
77.80
71.89
%
—
5
37
10
53
1.90
1.01
1.0
1.2
—
—
—
0
0
290
2667
1.14
1.00
6.6
5.5
10.72
12.69
umol/l
2.78
275
2492
34
249
1.38
0.99
5.2
4.2
1.86
1.58
%
0.88
34
234
20
132
1.53
0.98
2.7
2.4
54.00
90.49
ug/min
0.60
14
81
12
69
1.75
0.97
1.1
1.1
—
—
—
0
0
219
1982
1.15
0.95
2.7
2.2
85.05
79.38
nmol/l
1.63
191
1691
6
119
0.50
0.94
1.7
1.7
—
—
—
0
0
90
758
1.21
0.93
1.2
1.2
1.10
1.13
u/ml
0.02
25
178
10
55
1.83
0.92
1.7
1.7
—
—
—
0
0
73
602
1.24
0.92
1.3
1.2
29.09
38.12
iu/ml
0.44
29
195
30
219
1.38
0.90
1.4
1.3
—
—
—
0
0
132
1501
0.85
0.90
4.3
4.8
21.35
22.12
%
0.21
70
793
23
162
1.43
0.85
1.3
1.5
—
—
—
0
0
14
88
1.60
0.84
1.1
1.1
—
—
—
0
0
146
1638
0.87
0.84
2.3
2.0
151.65
287.90
u/l
1.66
139
1509
8
46
1.75
0.82
1.5
1.2
—
—
—
0
0
46
365
1.28
0.82
4.6
3.0
121.43
122.93
g/l
0.20
46
356
131
1475
0.87
0.79
1.9
1.6
19.27
20.02
nmol/l
0.20
116
1236
185
2034
0.88
0.79
4.7
3.5
—
—
—
0
0
14
90
1.57
0.78
1.5
1.4
—
—
—
0
0
347
3676
0.90
0.78
30.9
22.3
15.15
15.48
%
0.62
341
3580
6
34
1.77
0.76
1.2
1.1
—
—
—
0
0
10
59
1.70
0.76
1.8
1.6
—
—
—
0
0
15
99
1.53
0.76
1.0
1.1
—
28.15
—
0
6
47
381
1.25
0.72
1.7
1.5
—
—
—
0
0
11
68
1.63
0.72
1.2
1.1
—
—
—
0
0
7
40
1.76
0.71
1.7
1.5
—
—
—
0
0
223
2410
0.89
0.71
2.5
2.2
89.02
91.41
pmol/l
0.27
117
1229
7
41
1.71
0.70
1.0
1.1
58.57
48.76
u/l
—
7
33
73
623
1.19
0.69
3.2
3.8
75.27
32.02
ug/l
0.39
68
531
17
119
1.44
0.67
4.0
2.3
14.14
15.19
%
0.53
12
59
46
377
1.23
0.65
2.0
1.8
368.50
388.51
nmol/l
0.25
40
329
361
3434
1.10
0.62
6.5
4.0
19.54
16.38
mm/h
2.26
341
3065
10
63
1.60
0.62
1.5
1.2
—
—
—
0
0
294
2771
1.10
0.62
8.5
6.0
1.22
1.21
mmol/l
0.25
250
2301
22
287
0.76
0.59
3.9
3.6
25.22
23.80
mmol/l
1.37
22
275
20
150
1.34
0.56
1.2
1.0
—
—
—
0
0
15
108
1.40
0.53
1.7
1.5
—
—
—
0
0
22
170
1.30
0.52
1.1
1.1
214.46
121.60
iu/ml
—
7
56
116
1052
1.12
0.51
5.0
5.2
1.02
1.02
kg/l
0.01
22
175
48
408
1.19
0.51
1.8
1.7
—
—
—
0
0
9
65
1.39
0.50
7.1
5.8
13.10
13.20
mg/l
—
9
57
194
1812
1.09
0.49
5.6
5.0
—
—
—
0
0
66
580
1.15
0.48
4.6
3.5
3.09
2.00
mmol/l
1.49
59
456
173
1854
0.91
0.47
3.0
3.1
2.32
2.35
mmol/l
2.05
146
1576
31
255
1.22
0.46
3.7
2.2
—
—
—
0
0
126
1159
1.10
0.44
6.1
4.2
39.70
229.78
ng/l
4.24
111
1038
28
229
1.23
0.44
4.6
3.4
1.60
1.47
mmol/l
0.20
28
224
5
31
1.62
0.43
2.0
1.5
—
—
—
0
0
5
31
1.62
0.43
2.0
1.5
—
—
—
0
0
209
1972
1.08
0.42
3.7
2.7
154.86
152.71
ug/l
0.04
195
1743
6
93
0.64
0.42
2.0
1.6
—
—
—
0
0
18
228
0.78
0.42
1.4
3.0
319.31
13323.70
u/ml
0.59
13
192
0
15
0.00
0.41
0.0
1.7
—
1.22
—
0
15
5
34
1.47
0.40
2.6
2.5
—
—
—
0
0
66
589
1.13
0.40
3.0
2.6
4.42
5.87
ug/l
0.53
53
484
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
51
577
0.88
0.38
3.7
4.7
37.61
33.14
%
1.19
31
347
10
72
1.39
0.37
1.0
1.3
—
—
—
0
0
11
81
1.36
0.36
1.6
1.3
—
—
—
0
0
300
2886
1.06
0.36
21.4
21.8
1.45
1.44
inr
0.04
86
790
54
481
1.13
0.35
1.9
2.0
0.20
0.20
g/l
0.07
49
430
203
1930
1.07
0.34
2.9
2.3
—
—
—
0
0
243
2326
1.07
0.34
7.2
6.1
0.00
0.00
estimate
-0.00
52
433
140
1314
1.08
0.33
5.1
4.8
0.00
0.00
estimate
-0.00
46
421
13
100
1.31
0.33
1.6
1.4
—
—
—
0
0
244
2338
1.06
0.33
5.1
4.6
0.00
0.00
estimate
-0.00
59
495
51
455
1.13
0.33
2.2
1.7
—
—
—
0
0
114
1221
0.92
0.32
4.7
3.9
84.08
80.57
%
0.72
109
1190
55
495
1.12
0.31
4.1
2.8
4.06
4.27
kpa
0.44
50
471
245
2353
1.06
0.31
5.1
4.6
0.00
0.00
estimate
-0.00
54
433
315
3050
1.06
0.30
6.3
4.6
6.88
6.94
mmol/l
0.20
297
2878
106
992
1.08
0.28
2.3
1.6
1.60
1.49
mg/l
0.14
90
790
260
2508
1.06
0.28
8.2
5.5
1.21
1.21
mmol/l
0.50
241
2234
243
2347
1.05
0.25
5.5
4.4
76.87
62.80
ng/l
0.22
207
1841
168
1612
1.05
0.22
2.5
2.2
3.21
3.25
mg/l
0.06
146
1349
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
339
3469
0.96
0.21
6.2
5.6
35.86
3799.29
e6/l
—
7
75
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
132.57
—
0
11
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
1.44
—
0
5
0
13
0.00
0.21
0.0
1.2
—
107.72
—
0
13
13
108
1.21
0.20
1.8
1.5
—
—
—
0
0
6
49
1.23
0.20
2.0
1.7
—
—
—
0
0
30
331
0.90
0.18
3.6
3.0
0.31
0.40
e6/l
0.25
30
325
7
59
1.19
0.18
1.3
1.5
—
20.33
—
0
12
7
59
1.19
0.18
2.3
2.3
—
2.29
—
0
14
7
59
1.19
0.18
1.6
1.4
—
—
—
0
0
5
69
0.72
0.17
1.6
1.7
34.95
2.00
mg/l
—
5
53
58
616
0.94
0.16
4.3
4.0
—
—
—
0
0
20
178
1.13
0.15
1.3
1.3
—
54.91
—
0
16
11
93
1.19
0.14
1.2
1.1
30.12
43.52
u/l
0.38
11
80
34
314
1.09
0.14
3.9
6.6
25.81
24.88
mmol/l
0.70
34
309
10
118
0.85
0.14
2.5
2.2
2.13
2.00
mg/l
—
10
98
124
1282
0.96
0.13
4.2
2.8
360.47
9317.42
umol/l
6.40
108
1056
38
354
1.08
0.13
3.1
3.1
53.36
55.41
ml/min/173m2
0.09
11
164
34
366
0.93
0.13
1.5
1.3
—
—
—
0
0
9
108
0.83
0.13
1.0
1.3
—
—
—
0
0
53
559
0.94
0.12
3.0
2.5
5.80
10.58
umol/l
3.97
47
481
43
455
0.94
0.11
2.3
2.3
27.84
31.35
u/l
0.67
37
378
377
3724
1.02
0.11
9.4
7.0
77.50
82.65
u/l
2.26
358
3429
10
86
1.16
0.11
2.1
1.7
—
—
—
0
0
215
2190
0.97
0.10
3.3
2.7
—
—
—
0
0
115
1182
0.97
0.10
3.2
2.4
—
—
—
0
0
248
2442
1.02
0.09
3.5
3.0
39.51
55.66
u/l
6.10
231
2183
5
48
1.04
0.09
1.4
1.4
—
57.14
—
0
7
6
57
1.05
0.08
1.7
1.4
—
—
—
0
0
6
58
1.03
0.08
1.7
1.4
—
—
—
0
0
6
58
1.03
0.08
1.7
1.4
—
—
—
0
0
6
58
1.03
0.08
1.7
1.4
—
—
—
0
0
7
81
0.86
0.07
2.1
1.2
347.71
514.28
mg/l
—
7
76
16
173
0.92
0.06
1.1
1.2
—
—
—
0
0
245
2422
1.02
0.06
5.0
4.3
33.23
34.04
g/l
1.35
226
2206
134
1318
1.02
0.06
1.9
1.8
465.17
5497066.13
pmol/l
0.50
109
1037
129
1275
1.01
0.03
3.2
2.7
6.82
4.86
e6/l
0.62
121
1142
14
132
1.06
0.02
2.2
1.4
253.22
270.45
ug/g
—
9
76
142
1432
0.99
0.02
1.9
1.8
1175.28
1164.67
nmol/l
0.05
111
1047
147
1461
1.01
0.01
3.2
3.1
1061.89
363.15
mg/l
0.59
103
948
12
114
1.05
0.00
4.9
2.0
3.09
3.68
g/l
0.91
12
105
22
217
1.01
0.00
2.4
2.0
128.51
428.22
ug/l
2.79
22
205
15
152
0.99
0.00
1.1
1.2
—
—
—
0
0
147
1465
1.00
0.00
3.2
3.1
6.34
6.74
mmol/l
0.63
121
1177
156
1556
1.00
0.00
4.0
3.7
11.63
9.10
mg/mmol
0.24
110
984
33
328
1.01
0.00
1.3
1.3
—
—
—
0
0
15
151
0.99
0.00
1.1
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
221
1.00
0.00
3.0
2.2
0.23
0.36
u/ml
2.27
15
131
5
51
0.98
0.00
1.4
1.5
—
348.89
—
0
9
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
9
93
0.97
0.00
5.9
2.3
191.22
208.51
%
—
9
88
0
5
0.00
-0.00
0.0
1.0
—
56.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.5
—
105.75
—
0
6
5
56
0.89
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
100.83
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
64
0.94
-0.00
2.3
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
86.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.1
—
7.01
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
-0.00
1.7
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.5
—
105.33
—
0
6
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
96.63
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint AB1_SEQULAE_TUBERCU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_SEQULAE_TUBERCU | 1.853 [1.65, 2.08] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.197 |
During the follow-up period (1.1.1998 — 31.12.2019), 1167 out of 2052 females with AB1_SEQULAE_TUBERCU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_SEQULAE_TUBERCU | 1.985 [1.74, 2.26] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1711 out of 2517 males with AB1_SEQULAE_TUBERCU died.
Mortality risk
Mortality risk for people of age
years, who have AB1_SEQULAE_TUBERCU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | 0.327% |
| 5 | 0.906% | 2.259% |
| 10 | 2.454% | 5.349% |
| 15 | 4.857% | 10.109% |
| 20 | 8.247% | 17.206% |
Relationships between endpoints
↥Index endpoint: AB1_SEQULAE_TUBERCU – Sequelae of tuberculosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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