No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
758 |
4. Check minimum number of eventsNone |
758 |
5. Include endpointsNone |
758 |
6. Filter based on genotype QC (FinnGen only) |
758 |
Control definitions (FinnGen only)
- Control exclude
- AB1_SEQULEAE_OF_INFECTIONS_AND_PARASITES
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Sequelae of tuberculosis
based on the number of shared cases.
Similar with more cases:
- Sequelae of infectious and parasitic diseases
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12957 | 5086 | 7338 |
| Only index persons | 5957 | 2950 | 3007 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.15 | 0.21 |
| Only index persons | 0.11 | 0.11 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 67.14 | 68.05 | 66.71 |
| Only index persons | 66.85 | 67.27 | 66.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 758 | 283 | 475 |
| Unadjusted period prevalence (%) | 0.17 | 0.10 | 0.21 |
| Median age at first event (years) | 65.81 | 62.50 | 67.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 697
- Matched controls
- 6970
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
+∞
323.0
475
*
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
+∞
66.7
63
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
4.0
54.5
283
1017
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
558.5
53.2
52
*
1370X
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,MUU JÄLKITILA]
+∞
50.6
48
*
B90.0
ICD-10 Finland
Sequelae of central nervous system tuberculosis
+∞
45.3
43
*
01908
ICD-8 Finland
Late effects of tuberculosis, Sequelae aliae o tuberculosis organorum respirationis
+∞
45.3
43
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.9
41.7
206
682
R03AC02
ATC
salbutamol; inhalant
2.8
38.0
396
2201
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.6
36.9
143
373
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.3
36.8
227
881
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.1
36.7
162
479
R03DA04
ATC
theophylline; systemic, rectal
4.0
34.5
156
469
B90.2
ICD-10 Finland
Sequelae of tuberculosis of bones and joints
+∞
32.5
31
*
J96.1
ICD-10 Finland
Chronic respiratory failure
7.6
31.3
76
111
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
40.1
30.5
38
10
J47
ICD-10 Finland
Bronchiectasis
10.2
28.5
57
60
R03BB01
ATC
ipratropium bromide; inhalant
4.0
28.0
124
361
J45.9
ICD-10 Finland
Asthma, unspecified
3.0
26.9
185
752
R03BB04
ATC
tiotropium bromide; inhalant
3.2
26.8
167
633
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
3.2
24.8
149
548
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
58.2
24.2
28
5
J45.1
ICD-10 Finland
Nonallergic asthma
4.3
23.5
93
242
R03AC12
ATC
salmeterol; inhalant
4.0
23.4
99
275
R03BA01
ATC
beclometasone; inhalant
3.0
23.2
156
618
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
19.2
21.9
33
18
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
21.2
326
1991
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.8
20.5
154
650
H02AB06
ATC
prednisolone; systemic
2.1
20.5
366
2379
R03BA05
ATC
fluticasone; inhalant
2.5
17.4
150
679
J01AA02
ATC
doxycycline; systemic
2.1
16.8
523
4105
01904
ICD-8 Finland
Late effects of tuberculosis, Adhaesiones pleurae
+∞
16.7
16
*
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
7.4
16.0
38
54
R03BA02
ATC
budesonide; inhalant
2.4
16.0
150
705
R04.2
ICD-10 Finland
Haemoptysis
4.5
16.0
58
139
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.9
15.5
65
178
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.9
15.5
65
178
01909
ICD-8 Finland
Late effects of tuberculosis, Sequelae NUD o tuberculosis organorum respirationis
+∞
14.6
14
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
14.2
160
818
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.9
14.0
90
340
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
4.7
13.9
47
105
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
54.5
13.9
16
*
J01FA06
ATC
roxithromycin; oral
1.9
13.6
279
1814
B90.1
ICD-10 Finland
Sequelae of genitourinary tuberculosis
+∞
13.6
13
*
R03DC03
ATC
montelukast; oral
2.7
13.1
95
386
H02AB04
ATC
methylprednisolone; systemic
2.3
13.0
128
614
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
19.5
13.0
19
10
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
24.8
12.5
17
7
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.7
12.4
87
346
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
5.6
12.2
35
65
J01MA14
ATC
moxifloxacin; systemic
2.6
10.8
78
317
R03AK07
ATC
formoterol and budesonide; inhalant
2.2
10.8
115
568
R03AC13
ATC
formoterol; inhalant
3.0
10.6
61
215
XG410
NOMESCO Finland
Flow-volume spirometry
3.9
10.6
43
116
R03AC03
ATC
terbutaline; inhalant
2.3
10.6
107
515
R03BB02
ATC
oxitropium bromide; inhalant
5.8
10.5
29
52
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.0
10.4
60
211
J01MA12
ATC
levofloxacin; systemic
2.0
10.4
158
904
B90.8
ICD-10 Finland
Sequelae of tuberculosis of other organs
+∞
10.4
10
*
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
+∞
10.4
10
*
7863A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Haemoptysis
9.8
10.3
20
21
R05CB01
ATC
acetylcysteine; inhalant, oral
4.3
10.3
37
89
R06.0
ICD-10 Finland
Dyspnoea
1.8
10.3
202
1268
R95
ICPC
Chron obstructive pulmonary disease
4.2
10.1
37
91
78310
ICD-8 Finland
Symptoms referable to respiratory system, Haemoptysis
12.4
9.9
17
14
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
26.4
9.8
13
5
H02AB07
ATC
prednisone; oral
2.0
9.6
129
703
49300
ICD-8 Finland
Asthma, bronchiale
4.4
9.5
33
77
4912A
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS CHRONICA OBSTRUCTIVA]
6.0
9.4
25
43
1373X
ICD-9 Finland
Late effects of tuberculosis of bones and joints
+∞
9.4
9
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.5
9.3
42
125
J45.8
ICD-10 Finland
Mixed asthma
3.8
9.2
38
105
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
37.2
9.0
11
*
01210
ICD-8 Finland
Other respiratory tuberculosis, Tuberculosis pleurae, pleuritis exsudativa tuberculosa
27.9
8.5
11
*
A15.3
ICD-10 Finland
Tuberculosis of lung, confirmed by unspecified means
91.1
8.4
9
*
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
6.3
8.4
21
34
01931
ICD-8 Finland
Late effects of tuberculosis, Coxae
+∞
8.3
8
*
01900
ICD-8 Finland
Late effects of tuberculosis, Bronchiectasia
+∞
8.3
8
*
01930
ICD-8 Finland
Late effects of tuberculosis, Columnae vertebralis
+∞
8.3
8
*
1370D
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,PLEURAFIBROOSI]
+∞
8.3
8
*
01106
ICD-8 Finland
Pulmonary tuberculosis, Pulmonum alia sive NUD
+∞
8.3
8
*
01901
ICD-8 Finland
Late effects of tuberculosis, Emphysema
+∞
8.3
8
*
01903
ICD-8 Finland
Late effects of tuberculosis, Fibrosis pulmonum
+∞
8.3
8
*
01510
ICD-8 Finland
Tuberculosis of bones and joints, Of hip
+∞
8.3
8
*
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
4.3
7.8
27
64
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
25.3
7.6
10
*
TGC00
NOMESCO Finland
Bronchial lavation
4.5
7.5
25
57
01220
ICD-8 Finland
Other respiratory tuberculosis, Pleurisy with effusion without mention of cause
11.0
7.3
13
12
1370C
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,BRONKIEKTASIAT]
+∞
7.3
7
*
51899
ICD-8 Finland
Bronchiectasis
15.9
7.2
11
7
1240
FHL
Bronchoscopy
3.7
7.1
29
80
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
12.2
7.1
12
10
R96
ICPC
Asthma
2.4
7.0
56
242
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.6
6.9
29
83
R03AK
ATC
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
10.1
6.5
12
12
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
6.6
6.4
15
23
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
5.6
6.3
17
31
01500
ICD-8 Finland
Tuberculosis of bones and joints, Of vertebral column
+∞
6.3
6
*
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
+∞
6.3
6
*
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
103
212
5.47
48.57
4.8
2.8
—
—
—
0
0
35
66
5.51
17.93
6.4
3.5
—
—
—
0
0
46
136
3.54
13.36
2.3
1.3
—
—
—
0
0
19
32
6.06
10.90
5.6
5.0
—
—
—
0
0
34
116
3.02
7.90
1.6
1.5
40.72
35.45
iu/ml
0.04
12
34
25
71
3.61
7.75
1.1
1.2
—
—
—
0
0
108
685
1.67
5.37
4.5
6.0
5.54
5.02
kpa
3.46
103
645
24
87
2.82
5.08
1.3
1.5
—
—
—
0
0
106
683
1.64
4.96
4.5
6.0
2.96
1.37
mmol/l
3.21
91
517
29
119
2.49
4.85
1.5
1.5
—
—
—
0
0
261
2083
1.39
4.23
8.9
5.0
60.90
59.81
%
0.70
242
1907
264
2120
1.38
4.10
9.1
5.3
23.62
24.75
%
0.94
242
1925
49
270
1.87
3.97
1.8
1.8
1.02
2.84
ug/l
0.84
41
219
26
114
2.33
3.82
1.4
1.5
—
—
—
0
0
343
3979
0.75
3.79
4.4
4.5
4.25
4.32
mmol/l
0.67
309
3497
13
39
3.37
3.77
1.2
1.6
—
—
—
0
0
337
3918
0.75
3.77
4.4
4.5
1.44
1.43
mmol/l
0.13
302
3403
20
78
2.61
3.74
1.4
1.5
—
—
—
0
0
250
2021
1.35
3.64
3.9
3.3
2053.75
2397.98
ng/l
0.55
225
1738
18
69
2.65
3.49
1.4
1.5
—
—
—
0
0
19
75
2.57
3.48
1.4
1.4
—
—
—
0
0
327
3791
0.76
3.45
4.0
4.0
1.19
1.23
mmol/l
0.49
288
3254
353
4044
0.76
3.38
7.2
6.6
41.76
41.76
mmol/mol
0.00
318
3606
117
850
1.45
3.17
3.3
2.4
2.31
2.23
g/l
0.89
109
765
305
2583
1.30
3.11
11.2
7.6
4.61
4.48
e9/l
0.38
278
2221
139
1050
1.40
3.04
2.2
1.8
—
—
—
0
0
365
4131
0.78
3.02
4.8
5.1
2.39
2.46
mmol/l
0.81
329
3601
125
933
1.41
2.92
3.2
2.4
11.09
11.43
umol/l
0.23
115
838
7
13
5.42
2.87
2.4
1.2
—
—
—
0
0
5
6
8.38
2.75
1.0
1.7
—
—
—
0
0
71
486
1.51
2.61
7.9
5.8
11.89
12.58
mmol/l
0.31
60
453
430
4730
0.79
2.61
39.1
27.5
127.22
129.12
g/l
1.81
418
4581
430
4729
0.79
2.60
38.9
27.3
4.24
4.28
e12/l
0.98
415
4522
430
4728
0.79
2.59
39.3
27.3
243.06
234.62
e9/l
1.78
417
4541
11
38
2.92
2.59
1.3
1.6
—
—
—
0
0
57
374
1.57
2.54
4.4
3.9
5.62
5.15
kpa
2.23
52
340
26
136
1.94
2.53
1.4
1.3
—
—
—
0
0
101
747
1.41
2.50
2.1
1.8
—
—
—
0
0
108
809
1.39
2.48
3.5
2.5
19.74
21.05
%
0.40
86
683
18
84
2.17
2.36
3.1
3.3
1.14
1.62
%
0.25
11
67
53
349
1.56
2.34
4.5
4.0
2.62
2.02
mmol/l
0.47
41
258
426
4663
0.80
2.33
31.3
23.0
4.03
4.03
mmol/l
0.16
415
4480
426
4658
0.80
2.28
30.8
22.8
139.10
139.47
mmol/l
1.81
416
4479
6
13
4.64
2.27
1.2
1.1
—
—
—
0
0
27
150
1.83
2.23
2.3
1.5
—
—
—
0
0
332
3720
0.81
2.21
29.0
20.8
37.30
37.18
%
0.05
177
2140
98
738
1.38
2.19
2.1
1.8
—
—
—
0
0
67
931
0.69
2.19
4.4
3.1
1.99
1.28
e6/l
0.40
38
553
416
4537
0.82
2.06
13.9
10.6
21.38
22.55
u/l
1.13
397
4281
11
44
2.52
2.02
1.5
1.5
—
—
—
0
0
11
44
2.52
2.02
1.5
1.5
—
—
—
0
0
11
44
2.52
2.02
1.5
1.5
—
—
—
0
0
66
902
0.71
1.98
4.6
3.3
3.35
2.51
e6/l
0.25
37
529
32
195
1.67
1.96
3.2
3.4
65.02
91.41
mg/l
0.35
26
159
23
127
1.84
1.96
5.0
5.0
101.83
104.84
mmol/l
1.74
23
116
96
735
1.35
1.95
6.7
4.6
1.08
1.04
mmol/l
0.62
85
654
5
11
4.57
1.94
1.0
1.2
—
—
—
0
0
32
196
1.66
1.93
3.2
3.4
36.64
41.05
mg/l
0.20
26
161
0
50
0.00
1.89
0.0
1.5
—
—
—
0
0
15
72
2.11
1.87
1.5
1.6
—
—
—
0
0
104
812
1.33
1.86
4.0
2.7
0.80
0.81
mmol/l
0.37
94
741
38
247
1.57
1.82
1.9
1.9
—
—
—
0
0
364
3982
0.83
1.71
23.8
18.4
69.36
67.16
ml/min/173m2
1.08
296
3298
179
1518
1.23
1.66
2.6
2.3
65.25
56.72
u/l
0.55
168
1389
5
14
3.59
1.62
1.6
1.5
0.32
0.11
nmol/l
—
5
8
77
991
0.75
1.59
1.6
1.6
1.23
1.24
mmol/l
0.06
65
800
385
4174
0.84
1.58
5.0
5.0
6.09
6.18
mmol/l
0.54
339
3606
43
298
1.47
1.57
4.0
8.0
26.11
24.46
mmol/l
2.29
37
268
366
3979
0.84
1.53
5.0
4.6
2.02
2.06
mu/l
0.26
335
3451
5
15
3.35
1.52
1.0
1.1
—
—
—
0
0
33
219
1.53
1.48
1.7
1.7
—
—
—
0
0
9
38
2.38
1.46
1.4
1.3
—
—
—
0
0
9
38
2.38
1.46
1.4
1.3
—
—
—
0
0
156
1325
1.22
1.43
2.8
2.8
29.99
35.09
u/l
1.03
148
1253
16
88
1.84
1.42
1.5
1.6
—
—
—
0
0
95
1167
0.79
1.39
2.7
3.2
2.47
2.47
mmol/l
0.04
80
1002
6
23
2.62
1.37
4.7
3.2
230.17
238.17
u/l
—
6
23
25
159
1.59
1.36
1.4
1.4
—
—
—
0
0
25
159
1.59
1.36
1.4
1.4
—
—
—
0
0
9
43
2.11
1.30
1.2
1.0
—
—
u/ml
—
0
0
19
114
1.68
1.29
1.2
1.7
9007.50
18430.14
e6/l
0.73
12
74
5
18
2.79
1.28
2.6
1.7
—
—
—
0
0
5
18
2.79
1.28
1.0
1.1
—
—
—
0
0
15
84
1.80
1.28
3.3
3.5
61.47
62.82
%
0.16
15
84
133
1560
0.82
1.27
4.6
3.5
0.57
0.52
e6/l
0.08
113
1224
418
4460
0.86
1.27
28.6
18.9
29.06
28.92
mg/l
0.03
376
3748
6
25
2.41
1.24
1.8
1.5
—
—
—
0
0
6
25
2.41
1.24
1.8
1.5
—
—
—
0
0
6
25
2.41
1.24
1.8
1.5
—
—
—
0
0
6
25
2.41
1.24
1.8
1.5
—
—
—
0
0
9
45
2.01
1.23
2.0
1.4
—
—
—
0
0
43
314
1.39
1.23
1.9
1.7
1.37
1.53
g/l
0.46
37
279
84
1031
0.79
1.23
3.5
3.3
0.80
0.89
ug/l
0.55
60
736
5
19
2.64
1.21
2.0
1.6
—
—
—
0
0
5
19
2.64
1.21
2.0
1.6
—
—
—
0
0
22
140
1.59
1.21
6.6
4.6
5.15
5.08
kpa
0.15
22
135
150
1728
0.84
1.19
4.5
3.6
24.03
133.37
e6/l
2.23
129
1373
296
3227
0.86
1.18
4.2
3.7
15.62
15.20
pmol/l
1.90
269
2771
5
20
2.51
1.15
3.2
1.6
—
—
—
0
0
66
523
1.29
1.12
3.3
2.4
65.85
65.34
g/l
0.19
57
455
10
51
1.97
1.11
1.9
1.5
77.80
71.89
%
—
5
37
69
551
1.28
1.11
1.3
1.2
19.43
10.34
u/ml
0.39
29
183
5
21
2.39
1.09
1.0
3.4
63.00
121.48
nmol/l
—
5
21
11
59
1.88
1.07
1.3
1.4
—
—
—
0
0
34
245
1.41
1.07
5.2
4.2
1.86
1.58
%
0.89
34
232
20
129
1.57
1.06
2.7
2.6
54.00
92.06
ug/min
0.62
14
79
7
33
2.13
1.05
3.1
3.5
—
—
—
0
0
14
82
1.72
1.05
2.9
3.0
4.99
4.76
e9/l
0.09
14
82
9
46
1.97
1.04
1.2
1.4
0.51
0.58
nmol/l
—
9
41
166
1874
0.85
1.03
4.7
5.5
3.35
6.59
ug/l
0.69
146
1609
50
638
0.77
1.02
13.3
10.0
—
—
—
0
0
10
53
1.90
1.01
1.0
1.2
—
—
—
0
0
284
2613
1.14
0.97
6.5
5.4
10.79
12.68
umol/l
2.52
270
2440
73
598
1.24
0.97
5.0
3.3
278.53
312.72
ng/l
0.34
66
548
142
1614
0.85
0.96
2.3
2.0
152.96
285.17
u/l
1.54
135
1488
56
445
1.28
0.96
3.0
3.7
94.44
96.31
ng/l
0.06
41
374
30
217
1.40
0.95
1.4
1.3
—
—
—
0
0
6
118
0.50
0.94
1.7
1.7
—
—
—
0
0
46
357
1.31
0.94
4.6
3.0
121.43
122.78
g/l
0.18
46
348
10
55
1.83
0.92
1.7
1.7
—
—
—
0
0
14
86
1.64
0.91
1.1
1.1
—
—
—
0
0
14
86
1.64
0.91
1.5
1.5
—
—
—
0
0
23
160
1.45
0.89
1.3
1.5
—
—
—
0
0
8
42
1.91
0.88
1.5
1.2
—
—
—
0
0
130
1472
0.86
0.84
4.4
4.8
21.35
22.12
%
0.21
70
775
214
1950
1.14
0.84
2.7
2.2
85.08
79.39
nmol/l
1.59
186
1668
181
1998
0.88
0.82
4.8
3.6
—
—
—
0
0
6
32
1.88
0.82
1.2
1.1
—
—
—
0
0
10
58
1.73
0.80
1.8
1.6
—
—
—
0
0
11
66
1.68
0.79
1.0
1.1
—
—
—
0
0
15
99
1.53
0.76
1.1
1.1
—
28.15
—
0
6
129
1448
0.87
0.75
1.9
1.6
19.44
20.03
nmol/l
0.15
114
1216
46
370
1.26
0.75
2.0
1.8
368.50
390.48
nmol/l
0.27
40
322
70
590
1.21
0.74
1.3
1.2
29.77
38.67
iu/ml
0.42
28
191
7
39
1.80
0.72
1.0
1.1
58.57
46.19
u/l
—
7
27
7
39
1.80
0.72
1.7
1.4
—
—
—
0
0
11
68
1.63
0.72
1.2
1.1
—
—
—
0
0
86
743
1.18
0.71
1.2
1.2
1.10
1.13
u/ml
0.03
25
176
17
118
1.45
0.69
4.0
2.3
14.14
15.19
%
0.53
12
59
46
377
1.23
0.66
1.7
1.5
—
—
—
0
0
10
62
1.62
0.65
1.5
1.2
—
—
—
0
0
71
609
1.18
0.64
3.2
3.7
78.68
28.11
ug/l
0.45
65
521
25
190
1.33
0.63
4.8
3.5
3.95
3.99
mmol/l
0.21
25
174
327
3444
0.91
0.62
31.2
22.9
14.25
14.12
%
0.86
321
3342
5
30
1.67
0.61
2.0
1.5
—
—
—
0
0
5
30
1.67
0.61
2.0
1.5
—
—
—
0
0
221
2367
0.91
0.59
2.5
2.2
89.16
91.33
pmol/l
0.24
116
1213
22
166
1.34
0.59
1.1
1.1
214.46
123.52
iu/ml
—
7
55
20
149
1.35
0.58
1.2
1.0
—
—
—
0
0
48
402
1.21
0.57
1.8
1.7
—
—
—
0
0
58
495
1.19
0.57
4.5
5.8
1.23
1.49
mmol/l
1.81
52
467
288
2722
1.09
0.57
8.4
6.1
1.22
1.21
mmol/l
0.28
245
2234
66
573
1.17
0.54
4.6
3.5
3.15
1.97
mmol/l
1.58
56
440
9
65
1.39
0.50
7.1
5.8
13.10
13.20
mg/l
—
9
57
34
280
1.22
0.49
3.1
2.3
0.70
0.67
%
0.25
34
271
7
107
0.65
0.49
1.0
1.3
—
—
—
0
0
352
3375
1.08
0.48
6.5
4.0
19.28
16.43
mm/h
1.89
332
3011
6
93
0.64
0.42
2.0
1.6
—
—
—
0
0
10
70
1.43
0.42
1.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
1.22
—
0
15
11
79
1.40
0.41
1.6
1.3
—
—
—
0
0
5
34
1.47
0.40
2.6
2.5
—
—
—
0
0
65
581
1.13
0.39
3.1
2.6
4.16
5.85
ug/l
0.65
52
478
30
252
1.20
0.38
3.8
2.2
4.01
3.69
g/l
0.50
17
179
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
55
487
1.14
0.38
4.1
2.8
4.06
4.28
kpa
0.47
50
463
30
253
1.19
0.37
3.8
2.2
7.57
7.55
g/l
0.02
17
183
30
253
1.19
0.37
3.8
2.2
—
—
—
0
0
330
3419
0.94
0.37
6.3
5.6
35.86
3799.29
e6/l
—
7
75
204
1935
1.07
0.37
3.7
2.7
151.57
153.08
ug/l
0.03
190
1711
172
1820
0.93
0.35
3.0
3.1
2.32
2.35
mmol/l
2.03
144
1534
13
99
1.32
0.35
1.6
1.4
—
—
—
0
0
14
108
1.30
0.35
1.7
1.5
—
—
—
0
0
257
2463
1.07
0.34
8.0
5.5
1.21
1.21
mmol/l
0.46
239
2175
105
973
1.09
0.34
2.3
1.7
1.61
1.48
mg/l
0.17
89
775
122
1140
1.08
0.33
6.1
4.2
40.43
229.15
ng/l
4.06
107
1019
28
238
1.18
0.33
4.0
2.2
11.09
10.06
g/l
0.64
22
200
53
474
1.13
0.33
1.9
2.0
0.20
0.20
g/l
0.07
48
423
50
448
1.12
0.30
2.2
1.7
—
—
—
0
0
198
1894
1.06
0.28
2.9
2.3
—
—
—
0
0
51
564
0.90
0.28
3.7
4.7
37.65
33.17
%
1.20
31
337
166
1584
1.06
0.26
2.5
2.2
3.23
3.25
mg/l
0.03
144
1326
240
2316
1.05
0.26
5.5
4.4
77.48
63.57
ng/l
0.22
205
1804
32
361
0.88
0.25
1.5
1.3
—
—
—
0
0
309
3003
1.05
0.25
6.2
4.6
6.88
6.94
mmol/l
0.22
291
2830
20
170
1.18
0.24
1.3
1.3
—
41.38
—
0
12
110
1039
1.07
0.24
5.1
5.2
1.02
1.02
kg/l
0.02
22
173
5
38
1.32
0.23
1.2
1.4
—
—
—
0
0
5
38
1.32
0.23
1.2
1.4
—
—
—
0
0
186
1789
1.05
0.23
5.7
5.0
—
—
—
0
0
56
607
0.92
0.23
4.4
4.0
—
—
—
0
0
41
450
0.91
0.21
2.3
2.3
28.20
31.44
u/l
0.57
35
374
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
1.44
—
0
5
0
13
0.00
0.21
0.0
1.2
—
107.72
—
0
13
34
307
1.11
0.20
3.9
6.7
25.81
24.85
mmol/l
0.73
34
302
6
48
1.25
0.20
2.0
1.6
—
—
—
0
0
120
1256
0.95
0.20
4.2
2.8
363.87
9597.43
umol/l
6.40
104
1024
38
348
1.10
0.18
3.2
3.2
53.36
55.08
ml/min/173m2
0.08
11
162
135
1297
1.05
0.18
5.2
4.8
0.00
0.00
estimate
0.00
44
414
7
59
1.19
0.18
1.6
1.4
—
—
—
0
0
7
59
1.19
0.18
1.3
1.5
—
20.33
—
0
12
7
59
1.19
0.18
2.3
2.3
—
2.29
—
0
14
51
547
0.93
0.17
3.1
2.3
5.87
10.27
umol/l
3.64
46
470
5
68
0.73
0.17
1.6
1.7
34.95
1.80
mg/l
—
5
50
11
92
1.20
0.16
1.2
1.1
30.12
43.93
u/l
0.39
11
79
8
73
1.10
0.15
1.0
1.1
—
—
—
0
0
30
328
0.91
0.15
3.6
3.0
0.31
0.41
e6/l
0.26
30
322
234
2291
1.03
0.13
7.3
6.1
0.00
0.00
estimate
0.00
50
426
234
2293
1.03
0.12
5.1
4.5
0.00
0.00
estimate
0.00
51
439
10
85
1.18
0.12
2.1
1.7
—
—
—
0
0
10
116
0.86
0.12
2.5
2.2
2.13
2.01
mg/l
—
10
97
236
2317
1.03
0.11
5.2
4.6
0.00
0.00
estimate
0.00
52
427
12
106
1.13
0.10
1.8
1.5
—
—
—
0
0
5
48
1.04
0.09
1.4
1.4
—
57.14
—
0
7
244
2403
1.02
0.09
3.5
3.0
39.77
55.47
u/l
5.67
227
2151
25
233
1.08
0.09
3.6
2.2
3.35
3.23
g/l
0.22
16
183
212
2155
0.98
0.09
5.6
4.3
—
—
—
0
0
6
57
1.05
0.08
1.7
1.4
—
—
—
0
0
6
58
1.03
0.08
1.7
1.4
—
—
—
0
0
6
58
1.03
0.08
1.7
1.4
—
—
—
0
0
6
58
1.03
0.08
1.7
1.4
—
—
—
0
0
100
976
1.03
0.07
32.7
31.7
1.43
1.48
inr
0.10
11
107
114
1165
0.97
0.07
3.2
2.4
—
—
—
0
0
7
80
0.87
0.07
2.1
1.2
347.71
514.07
mg/l
—
7
75
9
88
1.02
0.07
5.9
2.3
191.22
210.77
%
—
9
83
8
93
0.86
0.06
1.0
1.2
—
28.54
—
0
5
14
129
1.09
0.05
2.2
1.4
253.22
268.30
ug/g
—
9
74
139
1411
0.98
0.05
1.9
1.8
1172.63
1163.32
nmol/l
0.04
108
1034
12
110
1.09
0.05
4.9
2.0
3.09
3.72
g/l
1.00
12
101
368
3660
1.01
0.04
9.4
6.9
77.56
82.40
u/l
2.00
349
3370
240
2383
1.01
0.03
5.0
4.3
33.18
34.03
g/l
1.41
221
2167
16
169
0.95
0.03
1.1
1.2
—
—
—
0
0
33
320
1.03
0.03
1.3
1.3
—
—
—
0
0
129
1302
0.99
0.02
1.9
1.8
467.19
5539801.01
pmol/l
0.50
104
1029
10
93
1.08
0.02
5.2
2.2
99.70
85.92
%
—
10
88
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
217
0.97
0.01
2.9
2.2
0.23
0.36
u/ml
2.21
15
128
144
1434
1.01
0.00
3.2
3.1
1093.58
370.88
mg/l
0.60
100
925
21
214
0.98
0.00
2.5
2.0
132.25
430.52
ug/l
2.69
21
202
15
147
1.02
0.00
1.1
1.2
—
—
—
0
0
15
148
1.01
0.00
1.1
1.2
—
—
—
0
0
125
1254
1.00
0.00
3.2
2.8
7.00
4.96
e6/l
0.61
114
1096
144
1437
1.00
0.00
3.2
3.1
6.30
6.72
mmol/l
0.69
118
1153
153
1528
1.00
0.00
4.1
3.9
11.84
9.10
mg/mmol
0.26
108
969
6
59
1.02
0.00
1.7
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
96.63
—
0
8
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
56.00
—
0
5
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
0.00
2.3
2.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
86.60
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.5
—
105.33
—
0
6
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
0.31
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.5
—
105.75
—
0
6
5
51
0.98
0.00
1.4
1.5
—
348.89
—
0
9
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
100.83
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint AB1_SEQULAE_TUBERCU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_SEQULAE_TUBERCU | 1.853 [1.65, 2.08] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.197 |
During the follow-up period (1.1.1998 — 31.12.2019), 1167 out of 2052 females with AB1_SEQULAE_TUBERCU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_SEQULAE_TUBERCU | 1.985 [1.74, 2.26] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1711 out of 2517 males with AB1_SEQULAE_TUBERCU died.
Mortality risk
Mortality risk for people of age
years, who have AB1_SEQULAE_TUBERCU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | 0.327% |
| 5 | 0.906% | 2.259% |
| 10 | 2.454% | 5.349% |
| 15 | 4.857% | 10.109% |
| 20 | 8.247% | 17.206% |
Relationships between endpoints
↥Index endpoint: AB1_SEQULAE_TUBERCU – Sequelae of tuberculosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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