oral cavity cancer: A primary or metastatic malignant neoplasm involving the oral cavity. The majority are squamous cell carcinomas.
Benign neoplasm: Bones of skull and face
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_BONE_SKULL_FACE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
351 |
4. Check minimum number of eventsNone |
351 |
5. Include endpointsNone |
351 |
6. Filter based on genotype QC (FinnGen only) |
351 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Bones of skull and face
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Bones of skull and face
- Benign neoplasm of bone and articular cartilage
- Benign neoplasm of bone and articular cartilage
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2415 | 1490 | 909 |
| Only index persons | 2235 | 1407 | 828 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 44.74 | 46.07 | 42.50 |
| Only index persons | 44.51 | 45.72 | 42.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 351 | 263 | 88 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.04 |
| Median age at first event (years) | 49.97 | 49.02 | 52.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 310
- Matched controls
- 3100
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D16.49
ICD-10 Finland
Bones of skull and face
+∞
291.8
232
*
AAP10
NOMESCO Finland
Extirpation of a skull lesion
+∞
63.8
59
*
2130A
ICD-9 Finland
Benign neoplasm of bone and articular cartilage, Bones of skull and face
+∞
38.3
36
*
D16.40
ICD-10 Finland
Orbital bone
+∞
37.2
35
*
D16.41
ICD-10 Finland
Benign tumor of the maxillary bone originating in teeth
+∞
14.7
14
*
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
7.3
12.2
29
43
D16.90
ICD-10 Finland
Bone and articular cartilage, unspecified
124.4
11.5
12
*
AA1AD
NOMESCO Finland
CT of head and brain
2.6
11.0
91
422
D16.4
ICD-10 Finland
Benign neoplasm: Bones of skull and face
+∞
8.4
8
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
8.7
7.4
15
18
EEA10
NOMESCO Finland
Biopsy of maxilla
+∞
7.3
7
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.1
7.2
38
132
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
6.1
6.7
17
29
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
8.4
6.4
13
16
EEB00
NOMESCO Finland
Partial excision of maxilla
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
148
1147
1.50
3.38
4.3
4.4
35.5
36.2
g/l
0.86
136
1079
252
2187
1.54
3.26
4.1
4.0
12.0
10.9
mm/h
0.55
238
2010
195
1608
1.48
3.22
4.3
4.4
6.5
6.5
mmol/l
0.08
184
1486
179
1454
1.47
3.18
3.5
3.4
0.0
0.0
estimate
0.00
27
285
147
1149
1.48
3.17
3.7
3.5
—
—
—
0
0
178
1478
1.41
2.64
3.5
3.4
0.0
0.0
estimate
0.00
27
277
320
2987
1.81
2.59
15.2
13.9
3.9
3.9
mmol/l
0.09
313
2898
176
1467
1.40
2.51
4.8
4.7
0.0
0.0
estimate
0.50
29
286
319
2982
1.77
2.47
15.2
13.9
139.9
139.7
mmol/l
1.02
313
2898
133
1062
1.41
2.41
1.8
1.9
97.0
98.5
pmol/l
0.11
68
514
87
647
1.46
2.32
3.9
3.6
1.0
1.0
kg/l
0.73
14
81
88
666
1.43
2.13
1.9
2.1
—
—
—
0
0
102
793
1.40
2.12
3.8
3.7
0.0
0.0
estimate
0.50
26
283
226
2007
1.35
1.97
3.3
3.3
—
—
—
0
0
119
962
1.36
1.93
2.4
3.2
2.4
2.4
mmol/l
0.35
109
854
121
982
1.35
1.91
2.5
2.9
—
—
—
0
0
80
608
1.41
1.88
1.6
1.5
—
—
—
0
0
8
28
2.90
1.87
1.0
1.4
—
—
—
0
0
22
125
1.81
1.76
1.5
1.4
—
—
—
0
0
65
488
1.41
1.64
3.3
3.5
23.5
152.3
ng/l
3.25
45
358
14
70
2.04
1.61
2.7
2.6
—
—
—
0
0
312
2956
1.50
1.60
14.0
12.4
22.0
21.0
mg/l
0.22
250
2301
156
1341
1.29
1.59
3.9
3.9
—
—
—
0
0
26
161
1.66
1.57
1.6
1.7
—
—
—
0
0
65
499
1.37
1.44
2.5
2.8
2.4
2.4
mmol/l
0.84
57
437
5
16
3.15
1.44
1.4
2.4
—
—
—
0
0
154
1338
1.27
1.40
5.5
6.3
1.2
1.2
mmol/l
1.70
130
1133
243
2236
1.28
1.34
6.6
7.1
81.7
77.3
u/l
0.40
230
2097
252
2330
1.29
1.34
4.4
4.0
14.7
14.6
pmol/l
0.26
239
2126
32
219
1.51
1.31
2.2
2.4
21.3
17.1
au/ml
—
5
8
10
48
2.12
1.29
2.0
1.6
—
—
—
0
0
23
347
0.64
1.27
3.6
4.1
30.6
32.7
%
0.34
14
230
269
2515
1.30
1.26
15.6
15.1
13.6
13.6
%
0.03
261
2473
140
1215
1.25
1.25
5.2
5.6
1.2
1.2
mmol/l
1.18
128
1105
70
558
1.32
1.22
1.3
1.3
12.5
39.6
iu/ml
4.99
25
182
5
19
2.65
1.22
1.0
1.1
—
—
—
0
0
77
624
1.30
1.20
1.5
1.4
—
—
—
0
0
44
328
1.39
1.18
5.7
6.1
—
—
—
0
0
8
39
2.08
1.16
1.0
1.3
—
—
—
0
0
92
769
1.27
1.12
2.4
2.7
0.5
0.5
e6/l
0.00
67
562
290
2753
1.31
1.11
5.2
4.7
1.7
2.3
mu/l
0.66
275
2517
17
106
1.63
1.05
4.2
5.1
1.9
1.6
%
0.59
17
101
66
547
1.25
0.87
1.3
1.3
11.9
12.4
u/ml
0.02
28
222
76
643
1.23
0.84
1.9
1.7
0.8
1.0
mg/l
0.84
66
500
83
709
1.22
0.84
2.8
2.9
905.1
1073.7
ng/l
0.27
69
593
55
449
1.27
0.83
2.0
2.5
0.7
1.0
e6/l
0.72
30
235
13
81
1.63
0.82
1.1
1.1
—
—
—
0
0
284
2719
1.23
0.80
15.3
13.2
39.1
39.9
%
0.82
210
2062
20
279
0.70
0.79
5.0
3.1
—
—
—
0
0
13
82
1.61
0.79
1.5
1.4
—
—
—
0
0
26
193
1.37
0.75
1.2
1.2
239.6
268.8
u/ml
0.07
26
179
9
54
1.68
0.75
1.2
1.4
—
—
—
0
0
82
709
1.20
0.74
2.1
2.6
346.1
6738.5
umol/l
3.10
68
622
73
624
1.21
0.74
1.4
1.5
22.0
21.1
nmol/l
0.23
66
528
41
329
1.28
0.72
2.3
2.7
22.2
6.6
umol/l
0.80
35
283
65
551
1.22
0.71
1.8
1.6
450.4
15733207.7
pmol/l
0.50
58
464
185
1717
1.16
0.71
7.1
9.0
4.4
4.0
e9/l
1.18
160
1510
7
42
1.68
0.69
1.0
1.2
—
—
—
0
0
13
86
1.53
0.67
1.2
1.4
—
—
—
0
0
13
86
1.53
0.67
1.2
1.4
—
—
—
0
0
13
86
1.53
0.67
1.2
1.4
—
—
—
0
0
13
86
1.53
0.67
1.2
1.4
—
—
—
0
0
23
302
0.74
0.65
2.7
2.9
0.5
0.8
ug/l
2.42
14
203
11
71
1.57
0.63
1.3
1.5
—
—
—
0
0
9
139
0.64
0.62
1.8
1.5
—
—
—
0
0
320
3124
1.28
0.61
10.0
9.8
25.3
25.1
u/l
0.08
312
3023
8
52
1.55
0.60
1.0
1.1
—
—
—
0
0
35
283
1.26
0.59
8.4
7.2
14.0
12.5
kpa
0.92
35
274
35
283
1.26
0.59
8.4
7.3
5.2
5.3
kpa
0.16
35
272
99
890
1.16
0.57
2.4
2.4
55.1
57.5
u/l
0.30
94
831
6
37
1.63
0.56
1.3
1.6
—
—
—
0
0
46
388
1.21
0.55
2.0
2.0
—
—
—
0
0
6
38
1.59
0.54
2.5
2.7
15.2
47.1
u/ml
—
6
38
26
208
1.27
0.49
2.0
1.8
—
—
—
0
0
48
414
1.18
0.46
1.9
2.6
3.4
3.0
e6/l
0.13
22
201
35
293
1.22
0.46
2.0
1.7
—
—
—
0
0
29
239
1.23
0.44
8.5
7.4
119.9
121.1
g/l
0.15
29
234
52
455
1.17
0.43
1.8
1.6
1161.4
1249.1
nmol/l
0.28
41
339
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
297
2900
1.16
0.42
4.3
4.2
4.8
4.8
mmol/l
0.04
275
2703
8
61
1.32
0.40
1.3
1.3
—
—
—
0
0
20
160
1.27
0.39
12.6
7.7
24.5
25.2
mmol/l
0.52
20
160
111
1032
1.11
0.38
3.4
3.3
22.6
36.9
ng/l
1.18
60
672
13
99
1.33
0.36
1.2
1.5
—
—
—
0
0
16
126
1.28
0.36
1.7
2.2
12.2
12.7
nmol/l
0.09
16
115
6
42
1.44
0.35
1.3
1.6
—
—
—
0
0
6
46
1.31
0.33
1.0
1.1
—
—
—
0
0
6
90
0.66
0.33
5.2
1.6
—
215.0
—
0
8
15
119
1.27
0.32
1.6
1.4
248.5
278.7
miu/ml
—
8
63
300
2947
1.12
0.29
4.8
4.7
2.9
2.9
mmol/l
0.37
276
2735
284
2783
1.11
0.29
3.9
3.8
1.3
1.3
mmol/l
0.12
266
2576
40
357
1.14
0.28
1.8
1.9
—
—
—
0
0
8
65
1.24
0.27
1.1
1.2
132.8
198.8
e6/l
—
8
55
16
192
0.83
0.26
1.9
1.6
—
—
—
0
0
5
39
1.29
0.23
1.0
1.2
—
—
—
0
0
7
91
0.76
0.22
2.3
1.9
—
—
—
0
0
7
95
0.73
0.22
2.4
2.0
—
—
—
0
0
40
363
1.12
0.22
1.9
2.2
20.8
22.8
%
0.56
34
313
5
42
1.19
0.21
1.6
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
14
117
1.20
0.21
2.6
2.3
3678.2
3303.6
u/l
—
6
47
0
13
0.00
0.21
0.0
3.2
—
—
—
0
0
0
13
0.00
0.21
0.0
3.2
—
—
—
0
0
19
164
1.17
0.21
1.5
1.5
—
—
—
0
0
205
1997
1.06
0.20
2.9
3.0
38.6
45.2
u/l
0.90
193
1871
16
136
1.18
0.20
1.0
1.4
—
—
—
0
0
27
302
0.89
0.20
1.6
1.6
—
—
—
0
0
9
113
0.79
0.20
1.6
3.8
0.9
1.2
%
—
9
113
6
49
1.23
0.20
1.3
1.6
—
—
—
0
0
32
289
1.12
0.19
2.0
1.7
—
—
—
0
0
156
1509
1.06
0.19
5.9
5.9
12.3
10.8
umol/l
0.42
150
1429
270
2657
1.07
0.18
5.4
5.2
39.0
39.1
mmol/mol
0.06
254
2491
44
407
1.09
0.18
2.2
1.8
—
—
—
0
0
14
119
1.18
0.18
1.9
2.0
—
—
—
0
0
7
62
1.13
0.17
3.6
2.7
25.0
24.4
mmol/l
—
7
51
126
1216
1.06
0.17
2.2
2.2
79.9
77.0
nmol/l
0.57
115
1090
33
303
1.10
0.16
5.5
6.3
105.4
104.2
mmol/l
0.91
33
294
288
2845
1.07
0.15
4.6
4.2
5.8
5.8
mmol/l
0.15
263
2620
292
2886
1.07
0.15
4.2
4.2
1.5
1.5
mmol/l
0.71
270
2681
26
237
1.10
0.14
2.0
2.6
75.0
69.8
ml/min/173m2
—
10
102
19
170
1.12
0.14
1.0
1.0
—
—
—
0
0
281
2778
1.06
0.13
11.7
11.4
84.7
84.4
ml/min/173m2
0.09
230
2250
12
138
0.86
0.13
1.5
2.4
0.4
0.1
e6/l
0.66
12
132
75
719
1.05
0.13
1.3
1.2
0.9
1.9
u/ml
0.71
19
193
19
171
1.12
0.12
1.3
1.3
—
—
—
0
0
44
416
1.07
0.11
4.2
4.2
22.9
21.2
%
0.33
22
194
71
682
1.05
0.11
2.6
2.0
2.6
3.0
mg/l
1.21
65
589
13
145
0.89
0.09
1.7
1.3
—
—
—
0
0
5
48
1.04
0.09
1.4
1.3
—
—
—
0
0
5
48
1.04
0.09
1.4
1.3
—
—
—
0
0
7
65
1.08
0.08
1.9
1.7
—
—
—
0
0
27
286
0.94
0.07
3.2
4.1
191.7
44.1
ug/l
0.49
19
240
10
89
1.13
0.07
1.9
1.6
0.2
4.2
ug/l
—
10
83
24
253
0.94
0.05
2.0
2.2
0.2
0.2
g/l
0.10
24
237
10
90
1.11
0.05
1.1
1.1
—
—
—
0
0
10
91
1.10
0.04
1.0
1.1
—
—
—
0
0
11
102
1.08
0.03
1.1
2.3
—
—
—
0
0
23
238
0.96
0.02
1.2
1.2
102.2
143.6
iu/ml
—
6
104
10
98
1.02
0.00
1.8
1.6
—
—
—
0
0
11
108
1.02
0.00
1.4
1.9
—
—
—
0
0
15
148
1.01
0.00
4.3
4.7
1.9
1.4
mmol/l
—
8
111
135
1354
1.00
0.00
3.1
2.7
73.0
89.4
ug/l
1.38
126
1254
21
213
0.99
0.00
2.9
4.0
1.0
2.4
mmol/l
1.54
15
166
79
793
1.00
0.00
1.6
1.6
1.6
1.4
mmol/l
0.66
69
675
10
104
0.96
0.00
1.4
1.6
—
—
—
0
0
5
52
0.96
0.00
1.0
1.4
—
—
—
0
0
7
73
0.96
0.00
2.0
1.6
—
—
—
0
0
7
78
0.90
0.00
1.6
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
93.0
—
0
7
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
7
77
0.91
0.00
2.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
8.5
—
0
8
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
6
69
0.87
0.00
1.5
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
7
76
0.92
0.00
1.7
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
65.2
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_BONE_SKULL_FACE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BONE_SKULL_FACE | 1.02 [0.82, 1.26] | 0.858 |
| Birth year | 1.001 [0.99, 1.01] | 0.875 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 1100 females with CD2_BENIGN_BONE_SKULL_FACE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BONE_SKULL_FACE | 0.96 [0.73, 1.26] | 0.769 |
| Birth year | 0.99 [0.98, 1.0] | 0.056 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 659 males with CD2_BENIGN_BONE_SKULL_FACE died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_BONE_SKULL_FACE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.218% |
| 5 | 0.548% | 1.183% |
| 10 | 1.618% | 2.989% |
| 15 | 3.316% | 5.825% |
| 20 | 6.126% | 9.559% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_BONE_SKULL_FACE – Benign neoplasm: Bones of skull and face
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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