oral cavity cancer: A primary or metastatic malignant neoplasm involving the oral cavity. The majority are squamous cell carcinomas.
Benign neoplasm: Bones of skull and face
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_BONE_SKULL_FACE
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
377 |
4. Check minimum number of eventsNone |
377 |
5. Include endpointsNone |
377 |
6. Filter based on genotype QC (FinnGen only) |
369 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Bones of skull and face
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of bone and articular cartilage
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2415 | 1490 | 909 |
| Only index persons | 2235 | 1407 | 828 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 44.74 | 46.07 | 42.50 |
| Only index persons | 44.51 | 45.72 | 42.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 369 | 281 | 88 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.04 |
| Median age at first event (years) | 50.65 | 49.97 | 52.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 377
- Matched controls
- 3770
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D16.49
ICD-10 Finland
Bones of skull and face
+∞
307.7
286
*
AAP10
NOMESCO Finland
Extirpation of a skull lesion
899.1
77.2
73
*
D16.40
ICD-10 Finland
Orbital bone
+∞
46.9
44
*
2130A
ICD-9 Finland
Benign neoplasm of bone and articular cartilage, Bones of skull and face
+∞
43.6
41
*
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
10.1
33.6
40
44
D16.41
ICD-10 Finland
Benign tumor of the maxillary bone originating in teeth
+∞
16.8
16
*
AA1AD
NOMESCO Finland
CT of head and brain
2.4
12.8
118
605
D16.90
ICD-10 Finland
Bone and articular cartilage, unspecified
72.4
12.7
14
*
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
6.5
12.6
21
34
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.9
9.8
48
178
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
2.7
8.6
49
197
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
10.4
8.1
15
15
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
4.1
7.5
21
54
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
7.1
7.4
17
25
D16.4
ICD-10 Finland
Benign neoplasm: Bones of skull and face
+∞
7.3
7
*
EEA10
NOMESCO Finland
Biopsy of maxilla
40.8
6.8
8
*
9102
FHL
Trepanation or removal of the local bone process
17.1
6.8
10
6
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
10.3
6.6
12
12
EFA10
NOMESCO Finland
Excision of lesion of jaws
+∞
6.3
6
*
AAK99
NOMESCO Finland
Other operation on skull or dura
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
196
1566
1.52
3.94
3.6
3.4
0.00
0.00
estimate
0.50
32
326
213
1733
1.53
3.93
4.2
4.5
6.46
6.56
mmol/l
0.37
199
1600
161
1238
1.52
3.85
4.1
4.4
35.53
36.21
g/l
0.79
146
1164
161
1239
1.52
3.83
3.7
3.5
—
—
—
0
0
271
2337
1.57
3.73
4.2
4.0
11.84
10.99
mm/h
0.43
256
2154
196
1589
1.49
3.54
3.6
3.4
0.00
0.00
estimate
-0.00
30
301
193
1575
1.46
3.28
4.9
4.6
0.00
0.00
estimate
0.50
32
309
148
1149
1.47
3.25
1.8
1.9
96.72
98.28
pmol/l
0.13
75
565
99
713
1.53
3.11
1.9
2.1
—
—
—
0
0
346
3218
1.91
3.08
15.1
13.9
3.94
3.95
mmol/l
0.05
339
3124
345
3210
1.88
3.00
15.1
13.8
139.91
139.69
mmol/l
1.08
339
3121
10
29
3.51
2.71
1.0
1.4
—
—
—
0
0
133
1043
1.43
2.66
2.5
2.8
—
—
—
0
0
92
684
1.46
2.43
4.0
3.5
1.01
1.02
kg/l
0.69
14
84
132
1053
1.39
2.35
2.3
3.2
2.37
2.36
mmol/l
0.37
117
943
89
662
1.45
2.34
1.6
1.5
—
—
—
0
0
110
856
1.40
2.25
3.8
3.6
0.00
0.00
estimate
0.50
29
306
245
2169
1.37
2.22
3.3
3.3
—
—
—
0
0
173
1453
1.35
2.20
2.4
2.4
—
—
—
0
0
30
181
1.71
1.95
1.6
1.7
—
—
—
0
0
5
11
4.59
1.94
1.8
2.5
34540.00
33736.82
ug/l
—
5
11
5
12
4.21
1.83
2.6
1.5
21.80
29.83
umol/l
—
5
12
79
605
1.39
1.76
1.3
1.3
12.00
39.37
iu/ml
5.95
29
208
72
544
1.40
1.73
2.4
2.8
2.43
2.45
mmol/l
0.70
62
479
335
3177
1.49
1.65
14.0
12.3
21.46
20.91
mg/l
0.11
271
2474
167
1439
1.29
1.64
5.3
6.4
1.21
1.22
mmol/l
1.72
141
1234
263
2403
1.31
1.63
6.6
7.1
81.18
77.17
u/l
0.39
248
2262
101
816
1.32
1.59
2.3
2.7
0.44
0.47
e6/l
0.03
73
602
49
352
1.45
1.56
6.1
6.2
—
—
—
0
0
11
51
2.19
1.52
2.0
1.6
—
—
—
0
0
76
593
1.35
1.51
1.3
1.3
9.67
11.48
u/ml
0.08
35
243
35
236
1.53
1.51
2.3
2.4
20.78
15.50
au/ml
—
6
11
272
2514
1.29
1.44
4.5
4.0
14.67
14.56
pmol/l
0.31
257
2300
151
1302
1.27
1.43
5.0
5.7
1.21
1.22
mmol/l
1.19
137
1197
298
2792
1.32
1.40
14.9
14.8
14.83
14.67
%
0.18
291
2753
56
421
1.39
1.40
1.9
2.0
—
—
—
0
0
5
17
2.97
1.36
1.4
2.4
—
—
—
0
0
22
136
1.66
1.36
1.5
1.4
—
—
—
0
0
85
686
1.31
1.34
1.5
1.4
—
—
—
0
0
14
76
1.87
1.31
2.7
2.6
—
—
—
0
0
67
525
1.34
1.30
3.2
3.4
24.45
144.68
ng/l
3.19
46
380
106
885
1.28
1.29
2.1
2.0
139.80
183.12
u/l
0.75
100
836
9
45
2.02
1.24
1.2
1.3
—
—
—
0
0
5
20
2.52
1.15
1.0
1.1
—
—
—
0
0
312
2965
1.30
1.15
5.3
4.8
1.74
2.25
mu/l
0.67
296
2720
82
676
1.27
1.11
1.5
1.5
21.63
21.20
nmol/l
0.11
73
577
20
301
0.65
1.10
5.0
3.1
—
—
—
0
0
363
3543
1.66
1.06
20.1
18.4
259.78
256.78
e9/l
0.43
357
3451
7
34
2.08
1.03
2.9
1.9
—
—
—
0
0
363
3545
1.65
1.03
20.2
18.5
39.69
40.08
%
0.55
341
3363
363
3546
1.64
1.01
20.0
18.4
4.50
4.47
e12/l
0.48
354
3452
90
760
1.24
0.99
2.2
2.5
342.41
6253.69
umol/l
3.10
75
673
59
474
1.29
0.98
2.0
2.5
1.19
1.03
e6/l
0.12
31
250
82
690
1.24
0.93
1.9
1.7
0.91
0.97
mg/l
0.10
70
538
200
1837
1.19
0.91
7.0
9.0
4.34
3.96
e9/l
1.26
173
1616
111
967
1.21
0.91
2.5
2.4
54.64
58.36
u/l
0.53
105
902
48
385
1.28
0.82
1.8
1.9
—
—
—
0
0
88
757
1.21
0.82
2.9
2.9
868.69
1046.46
ng/l
0.31
74
633
8
47
1.72
0.81
1.0
1.2
—
—
—
0
0
17
114
1.51
0.81
4.2
5.8
1.92
1.61
%
0.53
17
109
323
3116
1.26
0.80
4.3
4.2
4.80
4.81
mmol/l
0.03
301
2909
15
98
1.55
0.79
1.3
1.4
—
—
—
0
0
15
98
1.55
0.79
1.3
1.4
—
—
—
0
0
15
98
1.55
0.79
1.3
1.4
—
—
—
0
0
15
98
1.55
0.79
1.3
1.4
—
—
—
0
0
345
3357
1.33
0.78
10.1
9.8
25.16
25.06
u/l
0.05
336
3250
28
368
0.74
0.77
3.9
4.1
29.81
32.77
%
0.60
16
247
12
75
1.62
0.75
1.3
1.5
—
—
—
0
0
23
308
0.73
0.72
2.7
2.9
0.46
0.75
ug/l
2.43
14
209
115
1029
1.17
0.69
3.6
3.1
26.55
30.09
u/l
1.30
110
982
9
59
1.54
0.69
1.2
1.5
—
—
—
0
0
7
42
1.68
0.68
2.3
2.8
16.47
55.18
u/ml
—
7
42
22
162
1.38
0.68
5.7
7.6
25.57
25.26
mmol/l
0.21
22
157
13
86
1.53
0.67
1.1
1.1
—
—
—
0
0
30
234
1.31
0.65
1.9
1.8
—
—
—
0
0
43
352
1.25
0.65
2.3
2.7
21.14
6.62
umol/l
0.79
37
303
326
3165
1.22
0.64
4.8
4.6
2.89
2.85
mmol/l
0.35
304
2946
13
87
1.51
0.64
1.5
1.4
—
—
—
0
0
5
29
1.73
0.64
1.0
2.1
—
—
—
0
0
27
209
1.31
0.62
1.2
1.2
250.18
253.26
u/ml
0.01
27
195
164
1519
1.14
0.61
5.7
5.7
27.51
28.75
%
0.88
155
1429
174
1618
1.14
0.61
5.7
5.9
11.98
10.77
umol/l
0.37
166
1535
16
114
1.42
0.60
1.6
1.4
—
—
—
0
0
94
839
1.16
0.58
3.3
3.7
7.94
7.74
mg/mmol
0.02
63
505
68
591
1.18
0.58
1.9
1.6
452.54
14600446.15
pmol/l
0.50
61
500
8
55
1.46
0.56
1.0
1.1
—
—
—
0
0
6
37
1.63
0.56
1.3
1.3
—
—
—
0
0
37
304
1.24
0.55
8.0
7.8
14.12
12.59
kpa
0.95
37
295
37
304
1.24
0.55
8.0
7.8
5.21
5.24
kpa
0.10
37
293
140
1290
1.14
0.55
9.6
10.9
1.03
1.18
inr
5.79
36
417
294
2841
1.16
0.55
5.4
5.2
39.00
39.15
mmol/mol
0.10
277
2666
56
483
1.19
0.53
1.8
1.6
1168.81
1241.73
nmol/l
0.23
43
360
6
96
0.62
0.52
5.2
1.6
—
215.00
—
0
8
161
1502
1.13
0.52
5.5
5.5
58.74
56.78
%
1.57
152
1412
308
2993
1.16
0.49
3.9
3.7
1.26
1.25
mmol/l
0.09
286
2774
7
49
1.44
0.46
1.0
1.1
—
—
—
0
0
15
112
1.35
0.45
1.3
1.5
—
—
—
0
0
37
313
1.20
0.44
1.9
1.7
—
—
—
0
0
50
436
1.17
0.43
1.9
2.6
3.35
3.07
e6/l
0.10
22
215
140
1309
1.11
0.42
2.3
2.2
80.53
76.82
nmol/l
0.90
128
1177
23
186
1.25
0.41
1.3
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
119
1105
1.11
0.41
3.4
3.3
21.91
35.77
ng/l
1.24
65
712
5
35
1.43
0.39
1.0
1.9
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
317
3102
1.14
0.38
4.3
4.1
1.51
1.53
mmol/l
0.52
294
2890
16
125
1.29
0.37
1.8
2.0
—
—
—
0
0
6
41
1.47
0.36
1.3
1.6
—
—
—
0
0
306
2991
1.12
0.36
11.6
11.5
84.96
84.53
ml/min/173m2
0.13
250
2435
313
3064
1.13
0.35
4.6
4.1
5.80
5.82
mmol/l
0.12
287
2824
221
2129
1.09
0.34
3.0
3.0
37.84
45.00
u/l
1.12
206
1999
6
46
1.31
0.33
1.3
1.6
—
—
—
0
0
16
128
1.26
0.32
1.6
1.3
285.78
285.21
miu/ml
—
9
66
49
438
1.14
0.32
2.2
1.8
—
—
—
0
0
12
93
1.30
0.30
1.5
1.3
243.12
313.68
ug/g
—
6
55
7
57
1.23
0.29
1.1
1.7
—
—
—
0
0
7
57
1.23
0.29
1.1
1.7
—
—
—
0
0
10
76
1.32
0.28
1.2
1.2
106.30
201.48
e6/l
—
10
63
10
76
1.32
0.28
1.1
1.1
2.50
3.37
e6/l
—
10
60
8
63
1.28
0.28
3.5
3.8
56.37
56.89
%
—
8
63
22
187
1.19
0.27
1.5
1.5
—
—
—
0
0
20
169
1.19
0.26
12.6
7.8
24.47
25.15
mmol/l
0.51
20
169
12
149
0.80
0.26
1.7
1.5
—
—
—
0
0
28
319
0.87
0.26
1.6
1.6
—
—
—
0
0
6
82
0.73
0.24
1.3
1.2
—
—
—
0
0
14
115
1.23
0.24
1.4
1.8
—
—
—
0
0
5
38
1.32
0.23
1.2
1.7
—
—
—
0
0
5
38
1.32
0.23
1.2
1.7
—
—
—
0
0
13
157
0.82
0.23
1.7
1.3
—
—
—
0
0
5
42
1.19
0.21
1.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
12
98
1.23
0.21
1.2
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
16
136
1.18
0.20
1.7
2.1
12.19
11.91
nmol/l
0.05
16
124
0
14
0.00
0.20
0.0
2.3
—
—
—
0
0
0
14
0.00
0.20
0.0
3.2
—
—
—
0
0
0
14
0.00
0.20
0.0
3.2
—
—
—
0
0
12
99
1.22
0.20
1.2
1.1
—
—
—
0
0
34
309
1.11
0.19
2.0
1.7
—
—
—
0
0
5
69
0.72
0.17
2.2
1.5
—
—
—
0
0
10
120
0.83
0.17
1.5
3.7
0.83
1.21
%
—
10
120
8
70
1.15
0.16
1.3
1.3
—
—
—
0
0
35
322
1.10
0.16
5.3
6.6
105.26
104.28
mmol/l
0.77
35
322
6
80
0.75
0.15
1.5
1.5
—
—
—
0
0
7
89
0.78
0.14
1.7
1.5
—
—
—
0
0
12
103
1.17
0.14
1.8
1.7
0.16
3.96
ug/l
0.82
12
94
45
423
1.07
0.13
4.3
4.2
22.80
21.05
%
0.35
23
199
9
110
0.81
0.13
1.3
1.5
1.27
1.19
g/l
—
9
104
13
147
0.88
0.11
1.8
2.3
0.34
0.15
e6/l
0.46
13
141
10
115
0.87
0.11
1.4
3.7
0.49
0.67
%
—
10
115
81
782
1.05
0.10
1.3
1.2
0.87
1.78
u/ml
0.72
21
208
77
743
1.05
0.10
2.5
2.0
2.61
2.99
mg/l
1.12
70
647
5
44
1.14
0.10
1.6
1.9
—
—
—
0
0
15
135
1.12
0.10
2.8
2.3
3240.43
3260.60
u/l
—
7
56
5
45
1.11
0.10
1.2
1.5
—
—
—
0
0
5
45
1.11
0.10
3.0
2.0
13.40
13.24
%
—
5
45
19
207
0.91
0.09
1.9
1.6
—
—
—
0
0
5
47
1.06
0.09
1.2
1.3
6.70
7.19
mmol/l
—
5
39
6
54
1.11
0.09
1.3
1.6
—
—
—
0
0
149
1465
1.03
0.07
3.0
2.7
73.07
90.75
ug/l
1.69
140
1361
16
147
1.09
0.07
1.0
1.4
—
—
—
0
0
8
78
1.03
0.07
1.9
1.7
—
—
—
0
0
7
85
0.82
0.07
2.4
2.0
333.91
255.01
ug/l
—
7
79
87
850
1.03
0.06
1.6
1.6
1.55
1.39
mmol/l
0.62
76
726
20
187
1.07
0.06
1.0
1.0
—
—
—
0
0
27
256
1.06
0.06
2.0
2.5
75.00
69.47
ml/min/173m2
—
10
108
10
110
0.91
0.05
1.4
1.6
—
—
—
0
0
41
400
1.03
0.03
1.9
2.2
20.46
22.77
%
0.67
35
345
17
162
1.05
0.02
4.2
4.5
1.88
1.57
mmol/l
—
9
122
25
257
0.97
0.01
1.2
1.2
104.43
147.04
iu/ml
—
7
111
27
277
0.97
0.01
2.5
2.2
0.23
0.23
g/l
0.12
27
261
10
106
0.94
0.01
1.8
1.6
—
—
—
0
0
22
226
0.97
0.00
2.8
3.9
1.14
2.42
mmol/l
1.53
17
178
10
101
0.99
0.00
2.2
2.0
—
—
—
0
0
10
105
0.95
0.00
2.4
2.1
—
—
—
0
0
31
305
1.02
0.00
3.3
4.2
167.71
41.66
ug/l
0.48
22
255
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
8.49
—
0
8
6
61
0.98
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
65.20
—
0
5
5
59
0.85
-0.00
2.2
1.7
—
—
—
0
0
5
52
0.96
-0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
11
110
1.00
-0.00
1.1
2.3
—
—
—
0
0
8
84
0.95
-0.00
1.9
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
93.00
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
86
0.93
-0.00
1.5
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
52
0.96
-0.00
1.4
1.3
—
—
—
0
0
7
79
0.88
-0.00
1.9
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_BONE_SKULL_FACE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BONE_SKULL_FACE | 1.02 [0.82, 1.26] | 0.858 |
| Birth year | 1.001 [0.99, 1.01] | 0.875 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 1100 females with CD2_BENIGN_BONE_SKULL_FACE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BONE_SKULL_FACE | 0.96 [0.73, 1.26] | 0.769 |
| Birth year | 0.99 [0.98, 1.0] | 0.056 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 659 males with CD2_BENIGN_BONE_SKULL_FACE died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_BONE_SKULL_FACE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.218% |
| 5 | 0.548% | 1.183% |
| 10 | 1.618% | 2.989% |
| 15 | 3.316% | 5.825% |
| 20 | 6.126% | 9.559% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_BONE_SKULL_FACE – Benign neoplasm: Bones of skull and face
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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