No definition available.
Melanocytic naevi of eyelid, including canthus
EFO MESH Endpoint Browser PheWeb
CD2_BENIGN_MELANOCYTIC_EYELID
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
337 |
4. Check minimum number of eventsNone |
337 |
5. Include endpointsNone |
337 |
6. Filter based on genotype QC (FinnGen only) |
337 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D22
- Name in latin
- Naevus melanocyticus palpebrae
Similar endpoints
↥List of similar endpoints to
Melanocytic naevi of eyelid, including canthus
based on the number of shared cases.
Similar with more cases:
- Melanocytic naevi of eyelid, including canthus
- Melanocytic naevi
- Melanocytic naevi
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2724 | 1781 | 930 |
| Only index persons | 2569 | 1697 | 872 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 53.01 | 52.48 | 53.88 |
| Only index persons | 52.34 | 51.73 | 53.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 337 | 228 | 109 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.05 |
| Median age at first event (years) | 52.83 | 49.86 | 59.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 297
- Matched controls
- 2968
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D22.1
ICD-10 Finland
Melanocytic naevi of eyelid, including canthus
+∞
323.0
284
*
CBB30
NOMESCO Finland
Excision of lesion of eyelid
30.5
65.7
89
41
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
8.9
33.0
75
108
CBB99
NOMESCO Finland
Other excision or destruction of lesion of eyelid
78.9
13.7
15
*
2161A
ICD-9 Finland
Benign neoplasm of skin, Eyelid, including canthus[SILMÄLUOMEN BEN KASVAIN, NAEVUS PIGMENTOSUS]
+∞
13.6
13
*
D23.1
ICD-10 Finland
Benign neoplasm: Skin of eyelid, including canthus
6.3
11.1
29
50
CBA10
NOMESCO Finland
Biopsy of eyelid
12.9
9.5
16
13
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
7.2
9.0
21
31
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.3
8.2
41
137
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
3.4
7.1
33
104
P01AB01
ATC
metronidazole; oral, rectal
1.9
6.2
128
854
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
4.0
6.1
23
61
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
119
884
1.54
3.35
3.1
2.5
59.1
56.0
u/l
0.44
112
825
245
2120
1.57
3.34
4.2
4.0
11.6
11.5
mm/h
0.04
230
1953
248
2199
1.48
2.60
4.5
4.1
14.9
14.7
pmol/l
0.49
229
1996
286
2615
1.62
2.59
5.3
4.8
1.9
2.3
mu/l
0.52
268
2395
243
2163
1.44
2.35
7.5
7.3
77.1
77.5
u/l
0.05
231
2023
303
2834
1.69
2.22
13.5
13.1
23.7
22.2
mg/l
0.25
244
2219
189
1621
1.38
2.21
8.8
8.9
3.9
4.1
e9/l
0.51
169
1424
116
928
1.38
2.05
3.3
3.2
2.4
2.4
mmol/l
0.86
99
821
297
2782
1.57
1.94
4.8
4.4
4.7
4.7
mmol/l
0.38
278
2594
71
526
1.44
1.93
1.4
1.3
24.9
37.5
iu/ml
0.65
30
175
174
1500
1.33
1.84
5.5
5.9
10.5
10.7
umol/l
0.11
165
1427
91
712
1.38
1.82
2.3
2.6
329.8
7160.5
umol/l
3.40
76
611
69
516
1.42
1.79
1.4
1.3
12.7
8.8
u/ml
0.14
21
206
13
61
2.18
1.74
4.5
4.4
19.2
29.1
mg/l
0.60
13
39
7
26
2.73
1.59
1.0
1.2
—
—
—
0
0
136
1154
1.30
1.54
4.7
4.5
36.6
36.0
g/l
0.71
131
1085
299
2835
1.48
1.50
5.3
4.9
2.8
2.8
mmol/l
0.07
278
2627
293
2769
1.45
1.48
4.6
4.3
1.4
1.5
mmol/l
2.60
275
2563
284
2677
1.39
1.38
4.2
3.9
1.3
1.3
mmol/l
0.09
264
2467
180
1600
1.27
1.36
5.3
4.7
6.5
6.6
mmol/l
0.52
166
1466
154
1344
1.27
1.36
5.8
6.4
1.2
1.2
mmol/l
0.37
131
1145
12
61
2.00
1.34
1.0
1.3
—
—
—
0
0
13
230
0.55
1.32
3.3
3.6
5.8
5.8
kpa
0.08
13
222
6
24
2.53
1.31
1.2
1.4
—
—
—
0
0
152
1336
1.25
1.23
4.0
4.1
—
—
—
0
0
77
625
1.30
1.19
3.9
3.8
1.0
1.0
kg/l
0.12
13
83
274
2587
1.32
1.17
6.0
5.5
39.3
39.4
mmol/mol
0.07
258
2419
125
1086
1.24
1.10
1.9
1.9
97.3
97.5
pmol/l
0.01
52
555
205
1878
1.23
1.09
3.0
3.1
37.4
43.5
u/l
0.71
195
1757
11
59
1.89
1.08
2.6
1.9
118.2
129.3
g/l
—
6
37
135
1186
1.23
1.07
2.1
2.2
73.8
77.0
nmol/l
0.78
122
1049
200
1833
1.22
1.04
3.2
3.2
—
—
—
0
0
39
292
1.38
1.04
1.5
1.8
—
—
—
0
0
310
2995
1.44
1.02
11.3
10.2
25.5
25.0
u/l
0.11
300
2891
9
48
1.90
1.01
1.0
1.6
—
—
—
0
0
7
35
2.02
1.00
3.1
1.9
13.3
13.2
%
—
7
35
25
175
1.46
0.96
1.4
1.6
—
—
—
0
0
6
27
2.24
0.94
1.3
1.2
—
9.6
—
0
6
94
805
1.23
0.93
2.0
2.1
199.9
149.4
u/l
0.37
86
762
38
289
1.35
0.93
1.5
1.8
—
—
—
0
0
61
497
1.28
0.93
3.7
2.8
2.4
2.4
mmol/l
0.84
52
441
137
1222
1.20
0.90
5.3
5.7
1.2
1.2
mmol/l
0.09
124
1106
286
2740
1.29
0.90
4.5
4.4
5.9
5.9
mmol/l
0.33
267
2518
6
29
2.09
0.89
1.2
1.2
—
—
—
0
0
6
29
2.09
0.89
1.2
1.1
—
—
—
0
0
6
29
2.09
0.89
1.2
1.2
—
—
—
0
0
6
30
2.02
0.87
1.2
1.2
—
—
—
0
0
6
30
2.02
0.87
1.2
1.2
—
—
—
0
0
6
30
2.02
0.87
1.2
1.2
—
—
—
0
0
76
642
1.24
0.86
1.5
1.5
21.8
21.4
nmol/l
0.08
67
532
8
137
0.57
0.85
1.8
2.5
1.3
1.2
%
—
8
137
6
31
1.95
0.85
1.7
1.1
—
—
—
0
0
199
1845
1.19
0.84
4.5
4.3
1614.5
224.1
e6/l
0.65
12
36
64
532
1.25
0.83
1.6
1.5
—
—
—
0
0
89
767
1.22
0.83
3.9
3.7
0.0
0.0
estimate
0.50
27
252
77
655
1.23
0.82
2.0
2.0
2.3
3.0
mg/l
3.50
72
561
76
646
1.23
0.81
1.3
1.2
2.7
1.4
u/ml
0.29
21
186
6
34
1.78
0.76
1.2
1.1
—
—
—
0
0
7
40
1.77
0.71
1.0
1.1
—
—
—
0
0
7
41
1.72
0.70
1.0
1.0
—
—
—
0
0
5
27
1.86
0.68
1.2
1.4
—
—
—
0
0
50
415
1.24
0.67
1.5
1.9
—
—
—
0
0
24
183
1.34
0.61
1.5
1.3
—
39.8
—
0
11
13
186
0.69
0.61
1.4
1.5
—
—
—
0
0
18
131
1.40
0.60
1.2
1.5
—
—
—
0
0
56
477
1.21
0.60
1.5
1.7
1274.6
1195.2
nmol/l
0.25
43
354
0
22
0.00
0.59
0.0
1.1
—
14.0
—
0
22
6
35
1.73
0.58
1.2
1.1
—
—
—
0
0
14
98
1.45
0.57
3.4
1.5
297.2
298.2
mu/l
0.01
14
90
6
37
1.63
0.56
1.0
1.1
—
—
—
0
0
40
332
1.23
0.55
4.0
4.5
31.8
32.9
%
0.27
29
222
149
1383
1.14
0.55
3.5
3.5
0.0
0.0
estimate
0.00
27
263
275
2664
1.18
0.52
13.3
12.2
81.9
82.2
ml/min/173m2
0.09
231
2190
26
207
1.28
0.51
1.2
1.2
211.5
155.9
iu/ml
0.28
18
88
17
127
1.36
0.50
1.7
2.0
3.2
2.5
mg/l
0.18
11
86
75
670
1.15
0.48
4.7
4.8
2.6
2.5
ug/l
0.05
67
591
134
1245
1.13
0.47
3.0
2.7
169.7
104.7
ug/l
0.38
129
1145
32
265
1.23
0.46
3.8
3.1
—
—
—
0
0
61
538
1.16
0.46
5.9
4.5
24.9
21.1
%
0.79
30
262
40
341
1.20
0.44
28.1
19.4
2.0
1.3
inr
—
5
49
12
161
0.74
0.42
1.8
1.3
—
—
—
0
0
148
1393
1.11
0.41
4.5
4.8
0.0
0.0
estimate
0.00
29
261
0
17
0.00
0.41
0.0
3.1
—
614.5
—
0
17
13
97
1.35
0.40
1.8
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
12.9
—
0
18
0
18
0.00
0.40
0.0
2.1
—
—
—
0
0
36
308
1.19
0.39
1.7
1.7
1.4
1.4
%
0.09
29
268
9
69
1.31
0.37
1.0
1.2
—
—
—
0
0
149
1409
1.10
0.37
3.5
3.6
0.0
0.0
estimate
0.00
28
256
5
37
1.36
0.37
1.2
1.6
—
—
—
0
0
111
1034
1.11
0.37
3.2
3.6
25.1
34.5
ng/l
0.90
59
697
9
70
1.29
0.37
1.2
1.5
—
—
—
0
0
5
76
0.65
0.36
2.0
1.5
—
—
—
0
0
34
295
1.17
0.33
3.6
3.9
3.8
21.6
ug/l
0.65
27
241
34
389
0.86
0.32
2.3
3.0
1.0
0.7
ug/l
0.33
22
253
83
767
1.11
0.32
2.7
3.1
951.9
1110.4
ng/l
0.30
71
647
7
53
1.33
0.31
1.0
1.2
—
—
—
0
0
37
327
1.15
0.29
6.5
7.1
—
—
—
0
0
41
366
1.14
0.28
1.8
2.2
23.7
22.4
%
0.24
33
313
9
116
0.77
0.28
1.7
1.4
—
—
—
0
0
8
66
1.22
0.27
2.0
1.8
—
—
—
0
0
12
95
1.27
0.26
1.2
1.4
123.8
233.6
miu/ml
—
6
49
19
224
0.84
0.26
4.4
6.4
1.6
1.3
mmol/l
0.70
19
218
55
504
1.11
0.25
4.0
3.4
213.4
362.0
ng/l
0.38
40
381
9
76
1.19
0.25
1.0
1.1
—
—
—
0
0
13
106
1.24
0.23
1.3
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
8
101
0.79
0.21
1.0
1.1
—
—
—
0
0
8
102
0.78
0.21
1.0
1.1
—
—
—
0
0
58
539
1.09
0.21
1.5
1.4
—
—
—
0
0
5
43
1.17
0.21
1.4
1.6
—
—
—
0
0
39
427
0.90
0.21
2.4
2.7
4.6
2.9
e6/l
0.37
22
224
0
13
0.00
0.21
0.0
2.3
—
—
—
0
0
6
48
1.25
0.20
1.2
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
8.6
—
0
14
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
50
1.20
0.20
1.0
1.3
—
—
—
0
0
6
51
1.18
0.19
1.3
1.6
—
—
—
0
0
10
81
1.24
0.19
1.3
1.2
—
—
—
0
0
59
554
1.08
0.17
1.4
1.7
423.1
10776307.4
pmol/l
0.50
51
464
81
770
1.07
0.17
1.8
1.7
1.4
1.4
mmol/l
0.03
69
645
7
63
1.11
0.17
1.0
1.6
—
—
—
0
0
32
292
1.11
0.17
9.2
8.5
2.2
1.4
mmol/l
0.79
25
236
8
70
1.15
0.16
1.1
1.2
—
—
—
0
0
8
73
1.10
0.16
1.3
1.2
—
34.2
—
0
9
14
160
0.87
0.14
1.4
1.4
—
—
—
0
0
8
98
0.81
0.14
1.4
1.8
—
—
—
0
0
11
94
1.18
0.13
1.2
1.7
—
266.7
—
0
6
9
107
0.84
0.13
1.6
1.6
—
—
—
0
0
5
44
1.14
0.10
1.0
1.4
43.6
30.3
u/l
—
5
37
18
164
1.10
0.10
2.1
1.3
—
—
—
0
0
6
55
1.09
0.09
1.3
1.4
—
—
—
0
0
25
234
1.07
0.08
2.6
2.8
60.1
65.0
ml/min/173m2
0.43
12
103
5
64
0.78
0.08
1.6
1.6
—
—
—
0
0
7
65
1.08
0.08
1.3
1.2
—
1.0
—
0
6
7
67
1.05
0.08
1.1
1.2
—
—
—
0
0
8
74
1.08
0.07
1.4
1.5
—
—
—
0
0
7
81
0.86
0.07
1.0
1.6
—
—
—
0
0
9
100
0.90
0.06
3.6
3.7
25.2
24.2
mmol/l
—
9
91
17
158
1.08
0.06
3.6
2.5
0.1
0.2
e6/l
0.72
17
153
29
304
0.95
0.06
1.8
1.8
—
—
—
0
0
10
90
1.11
0.05
1.6
1.2
—
—
—
0
0
28
267
1.05
0.05
2.1
2.2
29.1
32.5
u/l
0.35
22
223
16
149
1.08
0.05
1.1
1.0
—
—
—
0
0
75
766
0.97
0.05
2.5
2.8
0.6
0.6
e6/l
0.03
55
562
26
272
0.95
0.05
1.5
1.6
—
—
—
0
0
32
332
0.96
0.04
1.8
1.9
—
—
—
0
0
63
642
0.98
0.03
1.6
1.6
1.1
1.1
mg/l
0.05
49
497
46
469
0.98
0.02
2.3
2.6
1.2
1.1
e6/l
0.13
27
263
11
104
1.06
0.01
1.4
2.2
9.3
10.4
g/l
0.67
11
92
82
826
0.99
0.00
4.5
4.0
16.1
11.8
mg/mmol
0.33
51
503
14
142
0.99
0.00
1.6
1.7
—
—
—
0
0
68
678
1.00
0.00
2.1
2.2
—
—
—
0
0
99
988
1.00
0.00
2.7
2.9
—
—
—
0
0
256
2561
1.00
0.00
15.2
14.2
40.5
39.9
%
0.63
183
1888
10
103
0.97
0.00
1.5
2.0
—
—
—
0
0
16
157
1.02
0.00
2.4
2.0
14.1
13.1
nmol/l
0.21
16
147
10
95
1.05
0.00
2.5
2.7
—
—
—
0
0
12
115
1.05
0.00
1.3
2.1
—
—
—
0
0
18
185
0.97
0.00
5.4
2.9
28.3
36.3
u/ml
0.25
18
177
11
106
1.04
0.00
1.1
1.4
—
—
—
0
0
24
244
0.98
0.00
2.0
2.1
0.2
0.2
g/l
0.07
24
232
110
1105
0.99
0.00
3.6
3.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
90.8
—
0
6
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.2
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
54
0.92
0.00
1.8
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
28.8
—
0
9
5
50
1.00
0.00
2.8
1.3
0.6
0.5
nmol/l
—
5
45
9
96
0.94
0.00
1.4
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_MELANOCYTIC_EYELID and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_EYELID | 1.0 [0.84, 1.19] | 0.997 |
| Birth year | 0.992 [0.98, 1.0] | 0.082 |
During the follow-up period (1.1.1998 — 31.12.2019), 204 out of 1551 females with CD2_BENIGN_MELANOCYTIC_EYELID died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_EYELID | 0.878 [0.71, 1.08] | 0.225 |
| Birth year | 0.99 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 131 out of 811 males with CD2_BENIGN_MELANOCYTIC_EYELID died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_MELANOCYTIC_EYELID.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.209% |
| 5 | 0.526% | 0.992% |
| 10 | 1.281% | 2.568% |
| 15 | 2.448% | 5.089% |
| 20 | 4.458% | 8.86% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_MELANOCYTIC_EYELID – Melanocytic naevi of eyelid, including canthus
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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