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Benign neoplasm: Rectum/anal canal icd-9

CD2_BENIGN_RECTUM_ANAL_CANAL_ICD9

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-9 2114
  • Hospital discharge: ICD-8 2114
  • Cause of death: ICD-9 2114
  • Cause of death: ICD-8 2114

2 out of 7 registries used, show all original rules.

362

4. Check minimum number of events

None

362

5. Include endpoints

None

362

6. Filter based on genotype QC (FinnGen only)

362

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 362 175 187
Unadjusted period prevalence (%) 0.07 0.06 0.08
Median age at first event (years) 47.97 44.33 51.38

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
341
Matched controls
3422
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
21140
ICD-8 Finland
Benign neoplasm of other parts of digestive system, Rectum
+∞
212.3
181
*
2114X
ICD-9 Finland
Benign neoplasm of other parts of digestive system, Rectum and anal canal[NEOPLASMA BENIGNUM ALIUD RECTI ET CANALIS ANALIS]
+∞
62.4
58
*
2114C
ICD-9 Finland
Benign neoplasm of other parts of digestive system, Rectum and anal canal[ADENOMA TUBULARE RECTI ET CANALIS ANALIS]
+∞
53.6
50
*
2114A
ICD-9 Finland
Benign neoplasm of other parts of digestive system, Rectum and anal canal[ADENOMA VILLOSUM RECTI ET CANALIS ANALIS]
+∞
36.1
34
*
6459
FHL
Other measure in this category
94.2
31.4
34
*
2114B
ICD-9 Finland
Benign neoplasm of other parts of digestive system, Rectum and anal canal[ADENOMA TUBULOVILLOSUM RECTI ET CANALIS ANALIS]
+∞
29.6
28
*
1471
FHL
Rectoscopy and polyp removal
77.9
19.9
22
*
45599
ICD-8 Finland
Haemorrhoids
7.4
19.6
48
74
1470
FHL
Rectoscopy
28.0
19.4
26
10
6449
FHL
Other measure in this category
+∞
18.9
18
*
56500
ICD-8 Finland
Anal fissure and fistula, Anal fissure
19.4
18.1
27
15
5690A
ICD-9 Finland
Other disorders of intestine, Anal and rectal polyp
39.1
12.3
15
*
6451
FHL
Dilatation
19.8
11.7
17
9
6453
FHL
Radical surgery of hemorrhoids
6.9
11.0
27
42
UJF32
NOMESCO Finland
Coloscopy
2.3
10.0
112
596
1491
FHL
Sigmoideoscopy and polyp removal
102.8
9.5
10
*
21136
ICD-8 Finland
Benign neoplasm of other parts of digestive system, Coli sigmoidei
+∞
8.4
8
*
6434
FHL
Anterior resection
34.2
8.1
10
*
1490
FHL
Sigmoideoscopy (fiberscope)
22.7
8.1
11
5
1370
FHL
Colonoscopy, whole colon
12.2
7.6
13
11
23040
ICD-8 Finland
Neoplasm of unspecified nature of digestive organs, Rectum
81.8
7.4
8
*
1380
FHL
Colonoscopy, left side
81.8
7.4
8
*
6431
FHL
Removal of local change, coagulation or cryotherapy in the laparatomy pathway
81.8
7.4
8
*
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
3.4
6.4
29
90
5650B
ICD-9 Finland
Anal fissure and fistula, Anal fissure[FISSURA ANI TYPICA]
18.4
6.3
9
5
2113C
ICD-9 Finland
Benign neoplasm of other parts of digestive system, Colon[ADENOMA TUBULARE COLI]
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
52
261
2.16
5.63
8.1
3.9
—
—
—
0
0
114
812
1.59
3.89
4.4
4.6
—
—
—
0
0
9
30
3.05
2.16
1.2
1.6
—
—
—
0
0
48
319
1.58
2.15
1.4
1.2
—
—
—
0
0
99
767
1.40
2.09
2.9
2.3
51.6
57.4
u/l
1.48
94
697
7
20
3.55
2.06
1.4
1.5
—
—
—
0
0
132
1088
1.34
1.86
5.0
4.4
—
—
—
0
0
101
803
1.36
1.80
2.8
2.8
—
—
—
0
0
38
256
1.54
1.64
1.2
1.2
—
—
—
0
0
5
14
3.61
1.62
3.6
2.0
—
—
—
0
0
91
724
1.34
1.60
3.8
3.0
6.8
6.7
mmol/l
0.14
73
576
6
20
3.03
1.58
1.8
2.6
—
—
—
0
0
78
608
1.36
1.57
2.9
2.8
13171.5
10211.4
umol/l
0.12
66
492
152
1304
1.29
1.55
6.1
5.6
10.0
11.6
umol/l
2.68
141
1218
6
21
2.89
1.51
1.2
1.0
—
—
—
0
0
9
37
2.47
1.49
1.3
1.2
—
—
—
0
0
30
196
1.58
1.48
2.2
1.9
124.9
198.3
ug/g
0.73
24
148
10
45
2.26
1.47
4.3
8.0
8.6
6.6
mmol/l
—
10
34
51
380
1.40
1.35
1.4
1.9
—
—
—
0
0
16
90
1.81
1.35
3.7
2.3
0.1
0.3
g/l
—
5
26
54
411
1.37
1.27
3.1
2.8
0.8
0.8
mmol/l
0.03
48
376
95
786
1.28
1.26
4.7
3.9
5.4
9.7
mg/mmol
1.33
60
485
13
70
1.89
1.25
3.8
4.6
1.4
1.4
mmol/l
0.02
13
63
42
309
1.41
1.21
1.2
1.3
3.0
10.2
u/ml
1.17
14
110
5
20
2.52
1.15
1.4
1.3
—
—
—
0
0
88
730
1.27
1.14
3.9
3.0
784.9
323.4
mg/l
0.26
56
460
7
30
2.36
1.13
1.9
1.3
—
—
—
0
0
98
827
1.25
1.10
4.1
4.2
—
—
—
0
0
5
21
2.40
1.09
1.0
1.0
—
—
—
0
0
165
1478
1.21
1.05
6.1
4.5
7.1
6.9
mmol/l
0.63
159
1379
38
283
1.38
1.04
1.5
1.4
—
—
—
0
0
28
197
1.46
1.03
3.7
3.5
—
—
—
0
0
88
740
1.25
1.01
2.4
2.3
2.7
3.3
mg/l
2.37
61
620
5
23
2.19
0.98
1.6
1.1
—
—
—
0
0
91
773
1.24
0.96
5.8
4.9
—
—
—
0
0
95
811
1.23
0.96
2.3
2.0
187.1
246.9
u/l
0.44
88
757
55
442
1.29
0.92
3.0
2.3
12.9
11.8
umol/l
0.52
50
397
19
127
1.52
0.90
1.5
1.3
—
—
—
0
0
26
187
1.42
0.88
2.2
1.4
—
—
—
0
0
23
162
1.45
0.86
1.8
1.4
—
—
—
0
0
38
293
1.33
0.86
1.5
1.3
—
—
—
0
0
148
1631
0.84
0.85
4.6
4.4
—
—
—
0
0
62
512
1.25
0.84
1.3
1.3
—
—
—
0
0
11
65
1.71
0.83
3.5
2.2
—
—
—
0
0
8
46
1.76
0.83
1.9
1.3
—
—
—
0
0
55
451
1.26
0.80
19.8
27.4
1.6
1.3
inr
0.83
19
52
37
288
1.32
0.79
3.5
4.0
9.4
35.8
ug/l
0.57
22
246
36
280
1.32
0.78
5.2
5.7
94.2
95.2
%
0.68
36
271
111
982
1.19
0.77
3.7
2.7
175.8
143.2
ug/l
0.64
90
866
10
59
1.71
0.76
1.6
1.5
—
—
—
0
0
9
54
1.68
0.75
2.6
2.1
—
—
—
0
0
47
382
1.26
0.74
3.3
2.4
23.8
21.2
%
0.55
40
333
7
38
1.86
0.74
3.3
3.8
—
—
—
0
0
7
39
1.81
0.73
4.7
2.3
5.7
5.2
e9/l
—
7
39
10
60
1.69
0.73
1.1
1.3
75.5
62.4
mmol/l
—
10
48
7
40
1.76
0.71
1.1
1.1
—
—
—
0
0
23
169
1.39
0.71
3.7
3.9
0.6
0.6
%
—
7
49
7
41
1.72
0.70
5.0
2.9
58.9
62.2
%
—
7
41
36
285
1.29
0.70
5.3
3.3
—
—
—
0
0
7
42
1.68
0.68
1.1
1.1
—
—
—
0
0
5
28
1.80
0.66
1.4
2.4
—
—
—
0
0
26
198
1.34
0.66
3.5
3.9
0.5
0.8
%
0.77
11
70
147
1347
1.15
0.65
9.1
5.9
1.2
1.2
mmol/l
0.37
126
1104
13
87
1.51
0.64
2.2
2.3
—
—
—
0
0
101
903
1.16
0.62
2.7
2.3
—
—
—
0
0
19
139
1.39
0.61
2.1
3.5
4.1
3.6
e9/l
0.36
11
93
35
282
1.27
0.61
4.2
2.8
60.9
68.4
e9/l
0.66
26
230
180
1680
1.14
0.60
6.0
4.9
—
—
—
0
0
216
2276
0.87
0.60
20.8
17.5
—
—
—
0
0
62
533
1.20
0.60
4.6
4.0
280.6
210.4
ng/l
0.16
54
461
8
52
1.55
0.60
1.3
1.1
—
—
—
0
0
22
167
1.34
0.58
1.3
1.5
—
—
—
0
0
33
266
1.26
0.58
1.6
2.8
66.3
65.9
g/l
0.13
27
232
6
36
1.68
0.57
2.7
1.9
89.1
89.3
%
—
6
36
197
1856
1.14
0.56
8.9
6.9
77.9
80.4
u/l
0.39
178
1704
6
37
1.63
0.56
2.3
1.8
67.2
58.3
%
—
6
37
181
1698
1.13
0.55
6.1
5.5
193.8
2251.1
e6/l
—
6
39
67
586
1.18
0.54
4.1
2.8
3.8
5.5
e6/l
1.63
58
511
9
62
1.46
0.53
1.8
1.2
—
—
—
0
0
6
39
1.55
0.53
1.8
1.5
—
—
—
0
0
6
39
1.55
0.53
1.8
1.7
—
—
—
0
0
30
243
1.26
0.51
1.5
1.3
862.2
538.6
titre
—
9
58
9
65
1.39
0.51
9.6
2.9
—
—
—
0
0
114
1043
1.14
0.51
5.8
5.1
0.6
0.6
%
0.05
100
957
17
127
1.36
0.50
10.7
3.5
—
—
—
0
0
90
993
0.88
0.49
13.3
10.5
0.0
0.0
e9/l
0.57
72
826
26
209
1.26
0.48
5.0
3.9
—
—
—
0
0
8
119
0.66
0.46
3.0
3.0
—
—
—
0
0
31
256
1.23
0.46
2.8
3.1
274.8
270.5
ng/l
0.02
31
237
31
372
0.82
0.46
2.2
1.7
2.1
2.7
g/l
1.36
21
213
16
121
1.34
0.45
7.6
6.6
—
—
—
0
0
10
69
1.46
0.44
1.5
1.6
—
—
—
0
0
23
184
1.27
0.44
3.7
4.0
0.2
0.2
%
0.07
11
64
178
1684
1.11
0.44
4.0
3.8
14.9
15.1
pmol/l
0.62
152
1454
7
51
1.38
0.44
7.7
2.3
—
—
—
0
0
116
1072
1.12
0.44
6.1
5.4
8.4
8.9
%
0.84
102
986
51
446
1.17
0.43
4.1
5.1
—
—
—
0
0
44
380
1.18
0.42
3.8
2.6
1.8
1.8
%
0.07
35
328
118
1095
1.12
0.41
6.0
5.4
25.0
25.6
%
0.20
104
993
5
33
1.52
0.41
1.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
2.6
—
—
—
0
0
39
335
1.18
0.40
1.4
1.3
14.0
35.7
iu/ml
—
6
109
17
215
0.78
0.40
8.5
4.5
—
—
—
0
0
121
1127
1.11
0.40
5.3
4.9
0.0
0.0
e9/l
0.10
100
978
8
61
1.32
0.40
1.3
1.2
—
2.6
—
0
7
14
106
1.33
0.39
1.1
1.3
—
48.0
—
0
7
123
1147
1.11
0.39
5.4
5.1
1.6
1.8
e9/l
1.67
99
1017
206
1972
1.10
0.39
4.7
4.2
1.2
1.2
mmol/l
0.04
175
1716
18
142
1.28
0.39
1.9
1.3
—
—
—
0
0
59
527
1.14
0.38
1.7
1.7
0.9
1.5
mg/l
2.08
48
422
115
1071
1.11
0.38
5.4
5.1
59.3
59.2
%
0.02
101
984
182
1736
1.10
0.37
4.6
4.1
16.6
15.8
mm/h
0.22
157
1550
131
1230
1.10
0.37
6.9
5.1
1.2
1.2
mmol/l
0.19
115
1079
6
42
1.44
0.35
1.2
1.4
—
—
—
0
0
77
704
1.12
0.35
1.5
1.6
23.4
21.0
nmol/l
0.46
58
579
26
218
1.21
0.35
1.8
1.4
—
—
—
0
0
114
1066
1.10
0.34
6.0
5.0
2.7
2.7
%
0.02
100
977
54
599
0.88
0.33
5.3
6.0
—
—
—
0
0
22
183
1.22
0.32
3.7
3.9
—
—
—
0
0
124
1170
1.09
0.31
5.5
5.1
0.2
0.2
e9/l
0.16
104
1027
7
100
0.69
0.31
1.1
1.3
48.8
194.6
u/ml
—
7
87
214
2067
1.09
0.31
5.1
4.7
4.5
4.4
mmol/l
0.22
186
1833
119
1122
1.09
0.30
5.3
4.9
0.6
0.6
e9/l
0.34
98
966
124
1174
1.09
0.29
5.3
3.9
35.0
34.4
g/l
0.60
110
1070
36
318
1.15
0.28
5.3
5.5
1.7
1.6
mmol/l
0.16
30
245
211
2045
1.08
0.26
5.2
4.7
1.5
1.5
mmol/l
0.32
181
1791
213
2069
1.07
0.24
7.6
6.7
41.7
41.5
mmol/mol
0.10
183
1867
37
411
0.89
0.24
1.2
1.2
0.6
1.1
u/ml
—
9
100
6
81
0.74
0.24
15.7
3.7
7.4
7.4
ph
—
6
67
17
143
1.20
0.23
3.1
2.6
—
—
—
0
0
220
2141
1.07
0.23
5.5
5.4
2.6
2.5
mmol/l
0.29
190
1879
5
39
1.29
0.23
1.0
1.1
3.9
4.1
mmol/l
—
5
33
26
229
1.15
0.22
1.6
2.3
—
—
—
0
0
50
542
0.91
0.22
1.8
1.6
1.2
1.2
mmol/l
0.38
40
431
13
107
1.22
0.22
1.2
1.3
—
—
—
0
0
39
428
0.90
0.21
3.8
3.2
0.9
0.9
ug/l
0.03
22
303
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
31
278
1.13
0.21
5.6
3.3
5.7
5.8
kpa
0.44
31
266
71
667
1.08
0.20
1.8
1.8
1042.2
1160.9
nmol/l
0.50
41
480
120
1150
1.07
0.20
16.6
10.1
1.6
1.3
inr
1.24
38
322
20
174
1.16
0.20
3.5
4.0
0.0
1.7
%
—
9
56
58
541
1.09
0.19
4.0
4.5
—
—
—
0
0
78
824
0.93
0.19
4.6
3.7
7.4
7.4
ph
0.17
16
158
100
954
1.07
0.19
4.3
3.8
—
—
—
0
0
24
213
1.14
0.19
5.2
3.4
138.4
88.3
ng/l
1.02
17
178
98
936
1.06
0.18
4.7
4.2
190.5
121.2
e6/l
0.28
78
693
62
658
0.93
0.17
5.5
4.3
—
—
—
0
0
14
162
0.86
0.16
3.4
3.1
8.8
10.1
g/l
0.76
14
144
8
71
1.13
0.16
1.4
1.7
—
—
—
0
0
13
111
1.18
0.16
6.8
5.5
—
—
—
0
0
15
130
1.16
0.16
1.2
1.2
—
—
—
0
0
14
159
0.88
0.13
1.4
1.6
—
—
—
0
0
192
1883
1.04
0.12
18.0
19.4
37.1
37.4
%
0.10
108
1139
67
700
0.95
0.12
3.9
3.4
—
—
—
0
0
66
631
1.06
0.12
1.6
1.8
443.0
458.3
pmol/l
0.15
50
508
56
588
0.94
0.12
3.3
3.5
—
—
—
0
0
86
831
1.05
0.11
4.4
3.6
171.9
152.7
e6/l
0.06
72
650
227
2238
1.04
0.11
22.6
18.2
26.7
27.3
mg/l
0.10
197
1849
209
2058
1.04
0.10
5.3
4.8
2.0
2.1
mu/l
0.60
179
1795
14
156
0.89
0.10
1.0
1.3
—
—
—
0
0
136
1330
1.04
0.10
8.5
8.1
4.5
4.3
e9/l
0.21
119
1163
56
584
0.95
0.10
2.8
3.1
2.5
2.5
mmol/l
0.55
48
495
56
584
0.95
0.10
3.9
3.2
511.3
551.8
mosm/kgh2o
0.98
48
494
217
2140
1.04
0.10
6.0
5.1
6.1
6.1
mmol/l
0.24
185
1875
13
145
0.89
0.09
7.0
7.3
24.9
24.4
mmol/l
0.24
13
132
5
47
1.06
0.09
1.2
1.1
30.6
47.9
u/l
—
5
40
234
2312
1.03
0.09
13.2
10.8
23.8
22.6
u/l
0.27
217
2186
234
2312
1.03
0.09
25.9
21.3
86.4
83.5
umol/l
0.38
234
2312
78
756
1.04
0.09
6.9
5.5
2.8
4.2
ug/l
0.59
69
652
6
55
1.09
0.09
4.0
2.5
—
—
—
0
0
119
1164
1.03
0.08
2.3
2.2
93.1
94.0
pmol/l
0.05
67
576
51
531
0.95
0.08
5.2
4.9
1.0
1.0
kg/l
1.04
12
82
242
2394
1.03
0.08
31.2
26.3
242.0
240.6
e9/l
0.13
234
2314
242
2395
1.03
0.08
31.2
26.3
91.9
91.7
fl
0.21
236
2334
242
2396
1.03
0.07
31.3
26.3
4.3
4.3
e12/l
0.92
233
2305
242
2396
1.03
0.07
31.3
26.4
6.9
7.0
e9/l
0.16
232
2304
242
2396
1.03
0.07
31.5
26.5
129.2
130.0
g/l
0.34
236
2333
242
2396
1.03
0.07
31.1
26.2
30.4
30.3
pg
0.14
236
2335
8
74
1.08
0.07
1.1
1.2
—
—
—
0
0
30
284
1.06
0.07
2.1
1.8
—
—
—
0
0
9
85
1.06
0.07
1.0
1.1
—
—
—
0
0
94
922
1.03
0.05
3.5
2.9
2.4
2.4
mmol/l
0.12
76
777
237
2353
1.02
0.04
25.8
21.6
139.1
139.5
mmol/l
1.26
231
2268
16
150
1.07
0.04
2.1
2.0
1.7
1.6
g/l
—
10
131
237
2354
1.02
0.04
26.2
21.7
4.0
4.0
mmol/l
0.28
230
2269
12
111
1.08
0.04
3.6
4.2
—
—
—
0
0
67
657
1.02
0.04
5.4
4.8
0.0
0.0
estimate
0.00
17
216
113
1117
1.02
0.03
5.0
4.5
32.3
73.2
ng/l
0.83
89
877
23
221
1.04
0.03
7.5
6.5
—
—
—
0
0
11
118
0.93
0.03
1.6
1.2
—
—
—
0
0
118
1168
1.02
0.02
5.2
4.5
0.0
0.0
estimate
0.00
21
225
76
750
1.02
0.02
4.1
3.4
0.5
0.6
e6/l
0.40
57
571
25
242
1.04
0.02
3.2
2.8
4.3
4.2
kpa
0.12
25
229
120
1190
1.01
0.02
5.2
4.6
0.0
0.0
estimate
0.00
19
215
15
157
0.95
0.01
7.5
4.8
—
—
—
0
0
117
1176
0.99
0.00
6.8
6.3
0.0
0.0
estimate
0.00
21
219
10
96
1.04
0.00
1.2
1.3
—
—
—
0
0
22
224
0.98
0.00
2.7
2.3
104.8
29.5
u/l
0.45
17
174
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
38.7
—
0
6
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
8
80
1.00
0.00
3.1
4.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
0.00
11.2
11.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
7
76
0.92
0.00
2.0
4.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
9
93
0.97
0.00
1.2
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
18.2
—
0
8

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_BENIGN_RECTUM_ANAL_CANAL_ICD9 – Benign neoplasm: Rectum/anal canal icd-9

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).