Benign neoplasm: Anus and anal canal

CD2_BENIGN_ANUS_ANAL_CANAL

anal neoplasm: A benign or malignant neoplasm that affects the anal canal or anal margin. Representative examples of benign neoplasms include squamous papilloma and papillary hidradenoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and melanoma.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D12.9&
  • Cause of death: ICD-10 D12.9&

2 out of 7 registries used, show all original rules.

1052

4. Check minimum number of events

None

1052

5. Include endpoints

None

1052

6. Filter based on genotype QC (FinnGen only)

1016

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D12
Name in latin
Neoplasma benignum ani

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6775 3595 3140
Only index persons 6211 3389 2822
Unadjusted period prevalence (%)
Whole population 0.10 0.10 0.09
Only index persons 0.12 0.12 0.11
Median age at first event (years)
Whole population 65.19 64.63 65.80
Only index persons 64.31 63.88 64.84

-FinnGen-

Key figures

All Female Male
Number of individuals 1016 530 486
Unadjusted period prevalence (%) 0.20 0.19 0.22
Median age at first event (years) 63.18 60.50 66.11

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1052
Matched controls
10516
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D12.9
ICD-10 Finland
Benign neoplasm: Anus and anal canal
+∞
307.7
1051
*
JHA20
NOMESCO Finland
Excision of lesion of anal canal or perianal tissue
58.1
300.7
171
35
UJF32
NOMESCO Finland
Coloscopy
8.5
264.5
700
1992
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
13.2
223.0
235
224
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
8.1
185.6
303
503
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
8.2
143.4
214
316
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
7.3
123.5
204
335
K62.0
ICD-10 Finland
Anal polyp
31.0
113.4
75
26
UJH02
NOMESCO Finland
Anoscopy
8.0
100.6
148
212
UJG02
NOMESCO Finland
Proctoscopy
10.7
84.9
96
98
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
5.4
75.3
166
354
JGA05
NOMESCO Finland
Endoscopic polypectomy in rectum
24.3
58.5
42
18
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
4.3
56.7
165
437
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
7.5
54.0
80
114
JHB00
NOMESCO Finland
Hemorrhoidectomy
6.7
52.9
88
142
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
6.1
51.9
95
169
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
5.1
48.7
109
233
JHA00
NOMESCO Finland
Anal or perianal incision
10.7
45.1
50
49
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
4.7
43.5
106
243
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
7.7
43.2
62
85
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.6
40.3
304
1412
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
39.3
413
2231
UJF30
NOMESCO Finland
Ileoscopy through colon
3.2
38.7
172
599
C05AA08
ATC
fluocortolone; rectal, topical
2.9
38.2
216
863
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
5.7
37.4
72
134
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
35.9
376
2013
D12.7
ICD-10 Finland
Benign neoplasm: Rectosigmoid junction
8.2
30.4
41
52
JGA73
NOMESCO Finland
Transanal excision of lesion of rectum
31.9
28.3
37
12
K60.1
ICD-10 Finland
Chronic anal fissure
5.8
28.1
52
93
D12
ICD-10 Finland
Benign neoplasm of colon, rectum, anus and anal canal
27.8
25.9
35
13
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
6.0
25.6
46
80
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.4
25.0
94
293
ZXE00
NOMESCO Finland
One hour or less
2.0
24.9
461
2976
K62.1
ICD-10 Finland
Rectal polyp
8.8
24.6
31
36
I84.5
ICD-10 Finland
External hemorrhoids without complication
4.5
23.9
60
140
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
21.1
310
1826
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
7.6
20.4
29
39
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
4.5
20.1
50
116
JHA10
NOMESCO Finland
Biopsy of anal canal
58.7
20.0
23
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
19.9
389
2510
C20.92
ICD-10 Finland
Malignant tumor of the rectum carcinoma of the adenoma
18.6
19.2
29
16
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
4.8
18.8
43
93
D37.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Colon
5.5
18.6
36
67
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
18.2
265
1546
K60.3
ICD-10 Finland
Anal fistula
5.8
18.1
33
58
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.4
16.9
130
591
Z2221
NOMESCO Finland
Medical doctor
1.8
16.0
306
1938
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.8
15.9
302
1908
N02AX02
ATC
tramadol; systemic, rectal
1.7
15.8
481
3474
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
7.3
15.7
23
32
K64.2
ICD-10 Finland
Third degree haemorrhoids
6.3
15.5
26
42
A02BC05
ATC
esomeprazole; systemic
1.7
15.3
441
3129
WX402
NOMESCO Finland
General anaesthesia
1.9
15.0
221
1286
J01DB01
ATC
cefalexin; oral
1.9
15.0
854
7287
A02BC03
ATC
lansoprazole; oral
1.7
14.7
334
2213
D04
ICPC
Rectal/anal pain
5.2
14.6
30
59
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
5.2
14.6
30
59
A02BC02
ATC
pantoprazole; systemic
1.7
14.6
723
5891
A06AC51
ATC
ispaghula, combinations; oral
2.9
14.5
72
264
N02BE01
ATC
paracetamol; systemic, rectal
2.2
14.3
940
8330
K60.2
ICD-10 Finland
Anal fissure, unspecified
5.2
14.2
29
57
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
14.1
215
1263
N03AX16
ATC
[U] pregabalin
1.8
13.9
264
1659
I84
ICD-10 Finland
Hemorrhoids
3.4
13.1
47
142
P01AB01
ATC
metronidazole; oral, rectal
1.6
13.1
411
2950
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
12.8
412
2971
I84.1
ICD-10 Finland
Internal hemorrhoids with other complications
3.7
12.4
39
108
I84.4
ICD-10 Finland
External hemorrhoids with other complications
5.2
12.2
25
49
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
12.2
162
906
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.7
12.0
67
261
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
12.0
141
756
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
14.9
11.8
19
13
K61.0
ICD-10 Finland
Anal abscess
5.0
11.7
25
51
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
11.5
242
1555
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
11.4
214
1332
UJF92
NOMESCO Finland
Capsular endoscopy
4.0
11.3
32
82
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
10.9
685
5694
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
10.9
181
1086
Z71.8
ICD-10 Finland
Other specified counselling
1.6
10.8
298
2051
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
3.0
10.7
47
161
K64.4
ICD-10 Finland
Residual haemorrhoidal skin tags
13.1
10.7
18
14
C21.1
ICD-10 Finland
Malignant neoplasm: Anal canal
60.6
10.6
12
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
10.6
129
700
WX002
NOMESCO Finland
Sedation and analgesia
1.7
10.5
219
1401
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
10.3
309
2165
K59.0
ICD-10 Finland
Constipation
2.3
10.2
75
334
R4110
NOMESCO Finland
Physiotherapy
1.6
10.1
290
2010
Z3231
NOMESCO Finland
Registered nurse
1.6
10.1
287
1986
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.7
9.9
54
209
JF2BD
NOMESCO Finland
Extensive colon CT
8.2
9.9
21
26
K92.1
ICD-10 Finland
Melaena
2.3
9.6
72
323
A02BC01
ATC
omeprazole; systemic
1.6
9.5
293
2062
D01
ICPC
Abdominal pain/cramps general
1.9
9.5
116
629
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
9.5
342
2494
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.2
9.3
81
387
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
9.3
184
1157
JG1CG
NOMESCO Finland
Extensive MRI of rectum
9.6
9.3
18
19
K64.9
ICD-10 Finland
Haemorrhoids, unspecified
3.0
9.2
41
142
K96
ICPC
Haemorrhoids
3.1
8.9
36
118
JGA75
NOMESCO Finland
Endoscopic microsurgical excision of lesion of rectum
50.4
8.7
10
*
JFF23
NOMESCO Finland
Transversostomy
4.3
8.7
22
52
K57
ICD-10 Finland
Diverticular disease of intestine
3.6
8.6
28
80
JFA45
NOMESCO Finland
Endoscopic contact coagulation in colon
10.1
8.5
16
16
JGA96
NOMESCO Finland
Other proctotomy or local operation on rectum
27.7
8.5
11
*
N06AB04
ATC
citalopram; systemic
1.6
8.4
209
1392
K60.0
ICD-10 Finland
Acute anal fissure
4.9
8.4
18
37
Z3226
NOMESCO Finland
Physiotherapist
1.6
8.3
190
1241
WX702
NOMESCO Finland
Supraglottic ventilation device
2.3
8.3
62
279
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.0
8.2
93
492
R35
ICD-10 Finland
Polyuria
2.1
8.2
80
401
A07EA02
ATC
hydrocortisone; rectal
3.4
8.1
28
83
S18
ICPC
Laceration/cut
1.5
8.0
465
3707
R60.0
ICD-10 Finland
Localized oedema
1.7
7.8
136
823
K62.3
ICD-10 Finland
Rectal prolapse
4.1
7.8
21
52
N05CF01
ATC
zopiclone; oral
1.5
7.8
338
2541
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
2.0
7.8
88
464
WX892
NOMESCO Finland
Monitored bed care
2.0
7.8
87
458
Z01.2
ICD-10 Finland
Dental examination
1.5
7.8
393
3047
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.2
7.7
30
96
JHC60
NOMESCO Finland
Transanal submucous or intersphincteric injection
45.3
7.7
9
*
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
1.6
7.7
185
1220
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.4
7.7
53
230
JN4BD
NOMESCO Finland
Extensive body CT
1.8
7.6
119
698
A03CA02
ATC
clidinium and psycholeptics; oral
2.1
7.6
69
336
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.6
7.6
42
164
H02AB06
ATC
prednisolone; systemic
1.4
7.6
478
3857
Z93.3
ICD-10 Finland
Colostomy status
6.2
7.6
19
31
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
7.5
483
3907
UJD02
NOMESCO Finland
Gastroscopy
2.3
7.5
56
251
A02BA04
ATC
nizatidine; systemic
1.9
7.4
89
480
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.2
7.4
58
266
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
7.3
366
2822
UJF34
NOMESCO Finland
Left colonoscopy
6.9
7.3
17
25
K64.1
ICD-10 Finland
Second degree haemorrhoids
3.3
7.3
27
84
L01
ICPC
Neck symptom/complaint
1.7
7.2
144
905
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
7.2
103
588
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
2.2
7.1
57
264
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
7.0
103
593
R01AD08
ATC
fluticasone; nasal
1.5
7.0
252
1819
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
7.0
107
624
G50.1
ICD-10 Finland
Atypical facial pain
3.3
6.9
25
77
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
6.8
434
3487
J02AC02
ATC
itraconazole; systemic
1.6
6.8
164
1081
A07EC02
ATC
mesalazine; oral, rectal
2.2
6.8
55
256
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
6.8
121
737
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
3.1
6.8
27
88
N06AX11
ATC
mirtazapine; oral
1.4
6.7
326
2492
M79.6
ICD-10 Finland
Pain in limb
1.4
6.7
402
3193
D16
ICPC
Rectal bleeding
2.9
6.7
30
105
M79.7
ICD-10 Finland
Fibromyalgia
2.6
6.7
37
145
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
2.5
6.7
39
157
C10AC01
ATC
colestyramine; oral
2.8
6.6
33
122
N06AX21
ATC
duloxetine; oral
1.7
6.6
112
674
JHB96
NOMESCO Finland
Other procedure for haemorrhoids or prolapse of mucosa
10.1
6.5
12
12
K62.9
ICD-10 Finland
Disease of anus and rectum, unspecified
7.4
6.4
14
19
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.5
6.4
202
1416
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.6
6.4
182
1247
ZXA05
NOMESCO Finland
Left side
1.5
6.4
260
1920
H53.1
ICD-10 Finland
Subjective visual disturbances
2.0
6.3
65
332
N05BA04
ATC
oxazepam; oral
1.5
6.3
251
1844
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
6.3
355
2782
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
6.3
160
1068
D01.2
ICD-10 Finland
Carcinoma in situ: Rectum
+∞
6.3
6
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.9
6.2
84
471
C21.0
ICD-10 Finland
Malignant neoplasm: Anus, unspecified
26.8
6.2
8
*
UKC02
NOMESCO Finland
Cystoscopy
1.6
6.2
174
1188
K57.9
ICD-10 Finland
Diverticular disease of intestine, part unspecified, without perforation or abscess
2.7
6.2
32
121
K62.8
ICD-10 Finland
Other specified diseases of anus and rectum
5.8
6.2
16
28
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
6.2
129
821
R06.5
ICD-10 Finland
Mouth breathing
1.9
6.1
80
444
JFA55
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in colon
7.7
6.1
13
17
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
6.1
474
3919
K64.0
ICD-10 Finland
First degree haemorrhoids
3.1
6.1
24
78
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.8
6.0
89
513
R03AC02
ATC
salbutamol; inhalant
1.4
6.0
517
4338
R32
ICD-10 Finland
Unspecified urinary incontinence
2.7
6.0
32
123

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
301
953
4.02
83.07
1.6
1.3
—
—
—
0
0
499
3383
1.90
22.65
2.6
2.2
—
—
—
0
0
544
3903
1.81
19.63
5.5
4.7
35.02
35.10
g/l
0.13
507
3609
215
1211
1.97
16.14
1.4
1.2
—
—
—
0
0
182
979
2.04
15.51
4.3
4.0
3.72
24.65
ug/l
1.77
156
815
770
6372
1.78
14.85
4.8
4.1
13.07
13.23
mm/h
0.10
707
5844
195
1108
1.93
14.12
1.4
1.3
—
—
—
0
0
484
3585
1.65
13.81
3.4
2.8
158.58
136.32
ug/l
0.32
451
3259
168
928
1.96
13.16
2.7
2.1
125.48
140.35
ug/g
0.27
124
736
619
4911
1.63
13.14
8.7
8.9
4.33
4.18
e9/l
0.64
534
4300
507
3857
1.61
12.59
6.1
5.7
0.66
0.67
%
0.03
476
3600
338
2327
1.67
12.56
2.6
2.2
3.04
3.13
mg/l
0.27
290
1960
520
3990
1.60
12.38
6.4
5.9
8.62
8.74
%
0.35
488
3733
556
4338
1.60
12.31
18.8
17.4
1.26
1.30
inr
0.46
153
1237
517
3968
1.59
12.25
6.1
5.7
2.76
2.84
%
0.37
484
3709
526
4073
1.58
11.86
6.2
5.8
26.93
26.81
%
0.09
495
3819
638
5178
1.59
11.66
5.2
4.7
6.78
6.75
mmol/l
0.10
605
4867
517
4004
1.57
11.54
5.8
5.6
57.83
58.05
%
0.14
485
3759
490
3749
1.57
11.53
2.2
2.1
97.73
94.15
pmol/l
0.84
262
1945
463
3507
1.57
11.32
2.3
2.2
79.85
78.31
nmol/l
0.58
407
3082
783
6706
1.65
11.18
9.4
7.5
78.48
78.94
u/l
0.09
739
6284
201
1235
1.77
11.15
2.6
2.5
21.69
22.42
%
0.28
172
1057
380
2762
1.59
11.03
3.2
2.5
59.34
89.17
u/l
0.51
343
2551
511
3976
1.55
10.98
6.8
6.0
—
—
—
0
0
714
6010
1.58
10.64
5.5
4.5
—
—
—
0
0
314
2202
1.61
10.50
4.5
3.8
88.61
87.77
%
0.23
308
2148
548
4366
1.53
10.33
6.1
5.8
0.19
0.19
e9/l
0.11
478
3811
220
1415
1.70
10.31
2.5
2.5
12.02
12.68
umol/l
0.69
207
1318
379
2790
1.56
10.23
3.1
2.5
—
—
—
0
0
533
4228
1.53
10.21
5.8
5.5
0.04
0.04
e9/l
0.18
463
3639
513
4052
1.52
9.93
3.0
2.6
—
—
—
0
0
204
1305
1.70
9.70
2.6
2.5
2.29
2.30
g/l
0.08
188
1211
538
4317
1.50
9.50
5.8
5.6
1.93
1.88
e9/l
0.14
476
3794
301
2134
1.57
9.45
3.0
2.4
—
—
—
0
0
526
4217
1.49
9.22
5.8
5.5
0.60
0.59
e9/l
0.18
459
3626
549
4448
1.49
9.09
7.3
6.6
1.21
1.21
mmol/l
0.07
461
3754
512
4093
1.49
9.04
6.4
5.8
1.21
1.21
mmol/l
0.19
471
3712
135
787
1.82
8.83
2.4
2.3
35.04
36.58
u/l
0.11
112
669
922
8403
1.78
8.73
20.8
15.7
23.06
25.34
mg/l
1.28
796
6781
410
3155
1.49
8.63
4.3
3.8
105.81
129.18
e6/l
0.23
296
2299
950
8747
1.88
8.55
23.5
18.5
3.97
3.99
mmol/l
1.56
927
8503
948
8733
1.86
8.37
23.0
18.4
139.58
139.63
mmol/l
0.27
927
8501
327
2415
1.51
8.35
3.5
3.2
—
—
—
0
0
345
2578
1.50
8.32
5.1
4.3
—
—
—
0
0
375
2872
1.47
7.92
3.2
3.3
—
—
—
0
0
562
4649
1.45
7.91
7.0
6.0
10.98
11.44
umol/l
0.53
532
4410
155
974
1.69
7.79
2.5
2.6
8.33
8.78
umol/l
0.09
125
849
800
7140
1.50
7.17
23.6
18.5
15.32
15.24
%
0.13
792
7025
392
3074
1.44
7.14
3.9
3.4
2.35
2.35
mmol/l
0.05
337
2688
624
5322
1.42
7.07
3.6
3.1
52.24
52.07
u/l
0.01
577
4913
725
6367
1.44
6.89
4.5
4.0
15.11
14.94
pmol/l
0.98
666
5720
329
2512
1.45
6.86
3.6
3.2
0.64
0.48
e6/l
0.23
252
1949
56
266
2.17
6.59
1.5
1.4
308.38
289.59
ug/g
0.30
37
163
254
1860
1.48
6.53
3.3
3.0
518.84
543.40
mosm/kgh2o
1.17
214
1606
351
2737
1.42
6.45
3.8
3.3
36.04
94.48
e6/l
1.51
274
2145
123
765
1.69
6.40
2.3
2.1
357.75
373.37
nmol/l
0.42
114
693
239
1737
1.49
6.36
4.1
4.1
110.18
312.98
ng/l
2.50
196
1421
302
2299
1.44
6.31
2.6
2.7
1676.37
6330.39
umol/l
2.27
268
1980
846
7709
1.50
6.18
5.4
4.8
1.93
2.11
mu/l
0.53
781
6953
203
1438
1.51
6.10
3.1
3.0
1.97
2.01
e6/l
0.02
107
802
350
2750
1.41
6.09
2.0
2.1
184.37
240.23
u/l
0.70
330
2580
122
768
1.67
6.07
1.5
1.4
—
—
—
0
0
857
7861
1.48
5.75
6.5
6.1
40.45
40.34
mmol/mol
0.12
792
7220
452
3746
1.36
5.56
11.8
9.7
0.00
0.00
e9/l
0.87
371
3073
130
850
1.60
5.56
2.3
2.1
0.21
0.21
g/l
0.16
117
796
186
1320
1.50
5.51
1.9
2.0
—
—
—
0
0
336
2672
1.38
5.31
4.8
4.0
7.40
7.40
ph
0.24
67
520
120
779
1.61
5.29
1.4
1.4
—
—
—
0
0
210
1539
1.45
5.28
2.8
2.8
1.24
1.10
e6/l
0.14
112
899
336
2680
1.37
5.19
2.9
3.1
33.15
32.54
u/l
0.11
307
2547
971
9215
1.69
4.98
29.8
23.1
246.41
245.60
e9/l
0.14
950
8985
110
710
1.61
4.97
3.6
3.8
88.79
87.72
ng/l
0.04
88
612
971
9216
1.69
4.96
29.7
23.0
91.30
91.40
fl
0.28
958
9068
971
9217
1.69
4.94
29.8
23.1
6.94
6.77
e9/l
1.41
951
8956
971
9217
1.69
4.94
29.6
22.9
30.29
30.37
pg
0.75
958
9067
971
9218
1.69
4.93
29.8
23.0
4.42
4.44
e12/l
0.53
950
8962
971
9219
1.69
4.91
30.0
23.2
132.63
134.01
g/l
2.04
958
9067
235
1783
1.41
4.85
4.0
3.0
2.46
2.46
mmol/l
0.17
200
1570
85
518
1.70
4.80
1.2
1.2
—
—
—
0
0
970
9215
1.67
4.79
29.9
23.1
39.73
39.73
%
0.01
908
8558
247
1899
1.39
4.71
1.8
1.6
1.23
1.23
mg/l
0.01
193
1464
924
8688
1.52
4.69
20.0
15.0
—
—
—
0
0
943
8906
1.56
4.68
13.1
10.7
24.88
25.19
u/l
0.27
913
8563
251
1945
1.38
4.55
3.0
2.6
5.89
5.52
e6/l
0.16
220
1769
151
1068
1.48
4.53
1.2
1.3
656.00
470.09
titre
0.38
30
230
120
810
1.54
4.49
2.8
2.6
64.28
70.61
e9/l
0.92
84
632
283
2243
1.36
4.44
1.7
1.6
19.54
20.49
nmol/l
0.49
243
1899
271
2134
1.36
4.43
7.4
6.6
—
—
—
0
0
194
1446
1.42
4.41
3.3
3.1
0.81
0.82
mmol/l
0.51
178
1349
162
1168
1.46
4.40
5.5
5.5
1.05
1.03
mmol/l
0.45
144
1071
187
1388
1.42
4.35
1.9
1.9
29.35
29.62
s
0.31
180
1335
678
6094
1.32
4.28
4.5
4.1
—
—
—
0
0
118
803
1.53
4.26
7.0
7.0
11.45
10.43
mmol/l
0.68
109
762
73
442
1.70
4.24
1.6
1.9
1.65
1.52
g/l
0.53
63
391
98
640
1.59
4.24
2.9
2.7
10.82
10.79
g/l
0.02
91
581
57
322
1.81
4.20
3.7
3.1
0.26
0.27
g/l
0.02
26
124
75
460
1.68
4.16
2.6
2.4
—
—
—
0
0
47
251
1.91
4.12
3.7
3.2
—
—
—
0
0
151
1092
1.45
4.04
2.7
2.5
1.67
1.83
%
1.36
131
976
121
838
1.50
4.02
6.0
6.2
1.44
1.37
mmol/l
0.20
116
816
9
14
6.47
3.98
1.7
1.3
58.78
48.29
umol/l
—
9
14
112
767
1.51
3.93
1.6
1.5
—
—
—
0
0
877
8225
1.40
3.93
5.2
4.8
6.01
6.00
mmol/l
0.05
802
7393
151
1099
1.44
3.90
6.0
6.6
5.03
5.09
kpa
0.30
138
1055
72
445
1.66
3.90
2.7
3.1
4.47
4.45
pmol/l
0.04
63
384
151
1100
1.43
3.88
6.0
6.6
12.06
11.91
kpa
0.15
140
1058
10
19
5.30
3.83
1.2
1.7
48.70
92.58
nmol/24h
—
10
19
150
1095
1.43
3.81
1.9
1.7
—
—
—
0
0
349
2906
1.30
3.80
2.8
3.0
1682.11
1554.61
ng/l
0.18
310
2498
150
1099
1.42
3.74
6.0
6.6
0.48
1.28
mmol/l
1.28
123
867
184
1397
1.38
3.73
1.3
1.3
30.97
35.35
iu/ml
0.20
51
461
417
3559
1.28
3.73
4.4
3.9
44.26
53.26
ng/l
0.31
287
2614
280
2273
1.32
3.65
1.6
1.7
1.34
1.37
mmol/l
0.31
227
1893
177
1344
1.38
3.59
1.3
1.2
7.09
13.96
u/ml
0.78
54
471
33
166
2.02
3.47
4.1
3.1
3.63
4.45
e9/l
1.60
33
166
110
771
1.48
3.47
7.1
7.6
—
—
—
0
0
216
1701
1.34
3.46
1.2
1.2
1.06
1.61
u/ml
0.57
41
439
34
173
2.00
3.46
4.2
3.4
56.65
59.26
%
0.57
34
173
58
351
1.69
3.42
4.9
3.2
122.23
4147.05
u/ml
0.79
53
297
234
1874
1.32
3.33
1.9
1.7
1053.07
1198.83
nmol/l
1.79
166
1385
20
83
2.44
3.31
1.1
1.2
—
—
—
0
0
108
763
1.46
3.28
5.7
4.1
—
—
—
0
0
391
3361
1.26
3.18
3.2
3.6
5.95
5.82
ph
0.35
30
209
194
1537
1.32
2.97
1.6
1.5
2.41
2.55
g/l
0.48
116
917
30
157
1.94
2.87
3.2
2.8
—
—
—
0
0
122
909
1.39
2.78
1.6
1.6
—
—
—
0
0
35
195
1.82
2.78
5.4
3.8
—
—
—
0
0
889
8463
1.32
2.75
5.4
5.1
2.70
2.68
mmol/l
0.22
830
7700
213
1729
1.29
2.72
3.6
3.1
0.78
0.80
ug/l
0.12
152
1179
72
492
1.50
2.62
8.4
8.7
—
—
—
0
0
15
62
2.44
2.54
2.5
2.7
7.44
6.82
mmol/l
—
8
38
36
210
1.74
2.49
1.2
1.2
—
—
—
0
0
21
102
2.08
2.48
1.5
1.3
—
—
nmol/l
—
0
0
74
515
1.47
2.47
2.2
1.7
2.35
1.50
g/l
0.50
65
465
128
987
1.34
2.37
6.1
6.9
96.10
95.46
%
1.02
122
955
21
104
2.04
2.37
1.5
1.3
—
—
—
0
0
90
656
1.41
2.36
3.4
4.0
0.88
0.59
%
0.53
43
221
26
141
1.86
2.29
2.5
2.9
—
—
—
0
0
33
196
1.71
2.17
4.0
2.5
16.50
15.93
%
0.31
21
101
23
122
1.90
2.17
2.0
1.7
0.88
0.90
g/l
0.02
17
92
90
671
1.37
2.09
3.0
2.6
—
—
—
0
0
105
803
1.34
2.08
2.8
3.1
275.93
228.26
ng/l
0.47
90
741
17
82
2.09
2.07
3.1
3.3
103.35
18.82
mg/l
—
10
61
17
82
2.09
2.07
1.6
1.2
—
—
—
0
0
28
466
0.59
2.06
3.8
3.8
—
—
—
0
0
34
207
1.66
2.06
1.2
1.3
—
—
—
0
0
832
7933
1.23
2.03
4.1
4.1
1.30
1.28
mmol/l
0.38
753
7132
91
684
1.36
2.02
3.8
4.2
0.00
0.13
%
5.19
42
221
57
394
1.47
2.01
2.4
2.7
—
—
—
0
0
96
730
1.35
1.98
3.7
4.1
0.72
0.98
%
0.79
47
265
858
8215
1.24
1.96
4.7
4.5
1.47
1.46
mmol/l
0.28
786
7448
86
644
1.36
1.96
3.5
4.2
0.03
0.60
%
0.63
37
183
41
266
1.56
1.94
1.6
1.6
—
—
—
0
0
63
450
1.42
1.89
1.9
1.6
—
—
—
0
0
82
618
1.35
1.81
1.4
1.4
—
—
—
0
0
9
35
2.58
1.80
2.4
2.7
40844.44
37545.86
ug/l
—
9
35
113
894
1.30
1.79
3.9
4.4
—
—
—
0
0
260
2258
1.20
1.77
4.2
3.6
—
—
—
0
0
19
102
1.88
1.76
4.8
4.9
—
—
—
0
0
464
4235
1.17
1.76
4.1
3.9
0.00
0.00
estimate
0.50
110
887
249
2155
1.20
1.76
1.4
1.4
—
—
—
0
0
31
193
1.62
1.76
3.0
3.0
80.32
1968.76
u/ml
0.82
26
181
77
579
1.36
1.73
1.2
1.1
—
—
—
0
0
340
3030
1.18
1.73
5.6
5.2
4.43
2.95
ug/l
0.40
306
2673
22
125
1.78
1.72
1.7
1.9
32.23
32.79
pg
0.22
22
125
16
83
1.94
1.65
1.8
1.1
—
—
—
0
0
79
603
1.33
1.63
5.0
3.6
7.44
7.40
ph
1.38
16
80
17
91
1.88
1.61
1.4
1.6
—
—
—
0
0
21
121
1.75
1.59
1.3
1.1
—
—
—
0
0
304
2703
1.17
1.57
4.3
4.1
—
—
—
0
0
72
545
1.34
1.57
2.3
3.0
3.83
6.32
e9/l
1.37
55
427
63
467
1.37
1.57
1.5
1.2
—
—
—
0
0
68
512
1.35
1.54
1.3
1.3
13.82
49.07
au/ml
—
5
29
7
27
2.60
1.51
1.1
1.9
—
—
—
0
0
859
8283
1.20
1.51
4.8
4.6
4.62
4.58
mmol/l
0.50
791
7581
79
611
1.32
1.50
5.1
3.6
5.11
5.16
kpa
0.17
74
585
18
102
1.78
1.45
2.2
2.2
—
—
—
0
0
11
52
2.13
1.44
1.2
1.1
276.91
244.96
mg/l
0.25
11
46
27
173
1.57
1.41
1.4
1.3
55.65
63.65
mmol/l
0.62
20
149
23
142
1.63
1.39
2.1
2.0
—
—
—
0
0
6
23
2.62
1.37
3.2
1.6
—
—
—
0
0
51
376
1.37
1.34
1.3
1.2
—
—
—
0
0
457
4232
1.14
1.32
5.4
5.2
0.00
0.00
estimate
0.50
107
824
9
43
2.10
1.30
1.7
1.4
—
—
—
0
0
81
648
1.27
1.23
3.2
4.3
—
—
—
0
0
29
196
1.49
1.22
1.2
1.2
—
—
—
0
0
29
196
1.49
1.22
7.1
4.5
2.99
2.62
mmol/l
0.23
22
137
308
2796
1.14
1.18
3.3
3.1
7.14
7.35
mmol/l
0.34
263
2325
20
125
1.61
1.18
1.7
1.4
—
—
—
0
0
21
133
1.59
1.17
3.9
2.7
—
—
—
0
0
5
20
2.51
1.15
1.6
2.6
6.36
7.87
mmol/l
—
5
13
459
4284
1.13
1.13
4.1
3.9
0.00
0.01
estimate
0.80
102
804
38
276
1.39
1.12
9.8
11.0
—
—
—
0
0
24
162
1.49
1.04
1.6
1.2
—
—
—
0
0
7
34
2.06
1.03
1.1
1.3
—
—
—
0
0
9
47
1.92
1.02
1.1
1.1
159.33
144.92
nmol/l
—
9
47
12
68
1.77
1.00
2.3
2.1
13.42
13.19
%
0.27
12
68
90
750
1.22
0.99
6.1
3.8
1.23
1.23
mmol/l
0.26
76
650
39
292
1.35
0.99
1.1
1.1
—
—
—
0
0
121
1038
1.19
0.98
1.3
1.4
—
—
—
0
0
0
29
0.00
0.98
0.0
1.0
—
—
—
0
0
0
31
0.00
0.96
0.0
1.1
—
21.33
—
0
6
223
2009
1.14
0.96
1.8
1.7
428.67
17241808.46
pmol/l
1.55
189
1624
28
199
1.42
0.96
3.5
2.2
127.32
128.61
g/l
0.10
22
153
17
109
1.57
0.93
1.2
1.2
—
—
—
0
0
46
359
1.29
0.90
1.6
1.4
—
—
—
0
0
99
843
1.19
0.89
1.7
1.6
—
—
—
0
0
55
440
1.26
0.89
5.2
3.8
—
—
—
0
0
8
42
1.91
0.88
2.9
7.1
—
—
—
0
0
8
42
1.91
0.88
1.1
1.4
1.58
1.60
g/l
—
8
42
100
854
1.19
0.87
3.6
3.4
1.61
2.01
mmol/l
0.54
82
702
308
2847
1.12
0.87
4.0
3.8
7.86
8.74
mg/mmol
0.19
198
1786
25
180
1.40
0.82
1.2
1.2
3.71
3.80
mmol/l
0.21
25
166
6
32
1.88
0.82
1.0
1.5
—
—
—
0
0
41
321
1.29
0.80
1.2
1.7
—
—
—
0
0
6
33
1.82
0.79
1.7
1.4
—
—
—
0
0
0
25
0.00
0.79
0.0
1.1
—
—
—
0
0
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
5
24
2.09
0.74
1.0
2.0
—
—
—
0
0
9
54
1.67
0.74
1.4
1.4
1.09
1.02
g/l
—
9
54
66
783
0.83
0.73
4.2
3.6
—
—
—
0
0
7
39
1.80
0.72
1.4
1.2
212.51
147.40
pmol/l
—
7
39
11
68
1.62
0.71
1.2
1.3
—
—
—
0
0
7
40
1.75
0.71
1.3
1.3
—
—
—
0
0
15
101
1.49
0.70
1.9
1.3
55.22
42.47
mu/l
0.21
15
92
10
61
1.64
0.68
1.3
1.7
—
—
—
0
0
23
170
1.36
0.67
1.3
1.3
192.91
234.27
miu/ml
—
10
71
7
121
0.58
0.67
4.3
2.6
—
—
—
0
0
16
226
0.70
0.67
2.9
2.5
—
—
—
0
0
21
153
1.38
0.67
1.1
1.4
—
—
—
0
0
36
285
1.27
0.67
4.3
6.3
1.55
1.30
mmol/l
0.32
28
252
17
119
1.44
0.67
1.5
1.3
2743.67
1558.69
e6/l
0.38
12
83
7
43
1.63
0.67
1.7
14.9
—
—
—
0
0
16
111
1.45
0.66
1.4
1.5
—
—
—
0
0
39
313
1.25
0.65
4.0
3.8
42.97
47.74
mg/l
0.14
30
259
39
313
1.25
0.65
4.0
3.7
93.52
72.75
mg/l
0.21
30
259
98
861
1.15
0.64
3.7
3.4
5.74
5.83
kpa
0.42
92
838
15
104
1.45
0.62
2.9
2.6
—
—
—
0
0
64
545
1.19
0.62
1.4
1.4
—
—
—
0
0
287
2689
1.09
0.62
3.5
3.2
1145.77
315.73
mg/l
1.00
188
1721
11
71
1.55
0.62
1.1
1.3
—
—
—
0
0
28
217
1.30
0.62
3.5
3.0
2.16
1.73
mg/l
0.86
28
197
29
226
1.29
0.62
3.6
4.1
—
—
—
0
0
27
209
1.30
0.60
1.2
1.2
11.32
9.81
u/ml
—
5
34
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
0
20
0.00
0.60
0.0
4.3
—
—
—
0
0
23
174
1.33
0.60
4.0
2.6
—
—
—
0
0
8
52
1.54
0.59
2.3
2.1
—
—
—
0
0
21
157
1.34
0.59
1.4
1.2
26.52
28.18
u/ml
—
5
13
58
493
1.19
0.58
1.3
1.3
—
—
—
0
0
6
36
1.67
0.56
1.0
1.2
5.42
6.57
mmol/l
—
6
36
6
36
1.67
0.56
1.2
1.4
—
—
—
0
0
46
384
1.21
0.56
4.7
4.8
1.48
1.58
%
0.44
41
364
115
1036
1.12
0.54
1.5
1.7
—
—
—
0
0
23
178
1.30
0.53
1.7
1.6
—
—
—
0
0
13
92
1.42
0.50
5.7
3.2
—
—
—
0
0
13
92
1.42
0.50
1.3
1.3
—
—
—
0
0
14
101
1.39
0.49
1.4
2.0
—
—
—
0
0
7
46
1.52
0.48
2.0
1.9
0.26
0.23
e9/l
—
7
41
13
93
1.40
0.48
1.6
1.4
163.54
307.52
pmol/l
2.57
13
82
7
48
1.46
0.47
2.0
1.8
505.86
637.80
e6/l
—
7
41
62
544
1.15
0.45
2.2
2.1
12.59
12.67
nmol/l
0.02
57
481
10
69
1.45
0.44
1.3
1.2
—
—
—
0
0
16
121
1.33
0.44
2.5
1.9
1050.17
1234.23
u/l
—
6
42
7
51
1.37
0.44
1.6
2.3
—
—
—
0
0
8
56
1.43
0.42
8.1
3.3
—
—
—
0
0
21
167
1.26
0.42
2.4
1.4
1.24
0.88
nmol/l
0.85
16
138
0
16
0.00
0.41
0.0
6.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
50
571
0.87
0.41
3.5
3.1
—
—
—
0
0
26
213
1.23
0.41
1.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
—
—
0
0
5
34
1.47
0.40
1.4
1.8
4.12
7.26
nmol/l
—
5
26
18
141
1.28
0.40
1.3
1.6
—
—
—
0
0
31
260
1.20
0.39
1.3
1.2
—
—
—
0
0
26
215
1.21
0.38
1.2
1.8
—
—
—
0
0
5
36
1.39
0.38
1.4
1.2
—
—
—
0
0
5
36
1.39
0.38
4.4
3.3
—
—
—
0
0
14
107
1.31
0.37
1.6
1.4
—
—
—
0
0
56
497
1.13
0.37
1.3
1.2
109.22
135.59
iu/ml
0.24
18
205
18
143
1.26
0.37
1.0
1.3
—
—
—
0
0
248
2362
1.06
0.36
4.9
4.2
0.00
0.01
estimate
0.88
98
799
11
81
1.36
0.36
1.5
1.3
—
38.00
—
0
5
11
81
1.36
0.36
1.0
1.2
—
—
—
0
0
6
42
1.43
0.35
1.2
1.0
—
—
—
0
0
178
1882
0.93
0.34
4.0
4.3
1.02
1.02
kg/l
0.12
27
262
6
45
1.33
0.33
1.0
1.0
—
—
—
0
0
40
350
1.15
0.33
1.1
1.1
—
97.29
—
0
7
7
96
0.73
0.31
1.9
2.4
—
—
—
0
0
12
93
1.29
0.30
1.6
1.3
—
—
—
0
0
20
166
1.21
0.30
1.2
1.5
—
—
—
0
0
20
168
1.19
0.27
1.2
1.5
—
—
—
0
0
20
168
1.19
0.27
1.2
1.5
—
—
—
0
0
12
95
1.27
0.26
1.0
1.1
—
—
—
0
0
12
95
1.27
0.26
1.0
1.1
—
—
—
0
0
5
73
0.68
0.26
1.0
1.1
—
—
—
0
0
13
105
1.24
0.24
1.5
1.3
15572.86
88707.30
e6/l
—
7
61
32
360
0.89
0.24
1.9
1.9
—
—
—
0
0
14
115
1.22
0.23
1.6
1.6
61.11
59.51
%
—
9
76
29
256
1.14
0.23
1.0
1.1
—
—
—
0
0
24
209
1.15
0.23
2.8
2.4
—
—
—
0
0
280
2718
1.04
0.21
3.1
3.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
88
828
1.07
0.21
2.2
2.6
7.48
6.91
ug/l
0.14
75
723
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
18
154
1.17
0.21
1.2
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
3.8
—
—
—
0
0
0
14
0.00
0.20
0.0
2.0
—
2.98
—
0
5
18
155
1.16
0.20
2.0
1.5
—
—
—
0
0
6
50
1.20
0.19
1.0
1.3
—
—
—
0
0
208
2011
1.04
0.19
3.4
3.8
—
—
—
0
0
7
58
1.21
0.18
1.4
1.1
—
—
—
0
0
7
61
1.15
0.17
1.0
1.0
—
—
—
0
0
7
62
1.13
0.17
2.1
2.7
—
—
—
0
0
7
62
1.13
0.17
1.4
1.6
—
—
—
0
0
5
68
0.73
0.17
2.0
2.5
—
—
—
0
0
10
120
0.83
0.16
1.1
1.1
—
7.94
—
0
5
22
246
0.89
0.16
3.7
5.1
—
—
—
0
0
62
584
1.07
0.16
1.3
1.4
—
—
—
0
0
43
401
1.07
0.14
2.0
1.9
0.61
2.01
ug/l
1.17
37
352
21
233
0.90
0.14
3.4
2.3
89.25
79.38
ug/min
0.06
13
144
8
98
0.81
0.13
1.3
1.1
—
—
—
0
0
36
385
0.93
0.12
4.5
4.0
—
—
—
0
0
12
105
1.14
0.11
1.4
1.2
—
—
—
0
0
12
105
1.14
0.11
1.2
1.2
—
—
—
0
0
58
607
0.95
0.11
5.6
6.2
25.38
24.53
mmol/l
1.16
53
582
14
125
1.12
0.10
1.3
1.6
—
—
—
0
0
5
44
1.14
0.10
1.0
1.4
4.96
6.02
ug/l
—
5
37
75
723
1.04
0.09
3.4
2.7
5.01
4.51
kpa
1.12
70
699
19
207
0.92
0.09
1.1
1.2
—
—
—
0
0
6
56
1.07
0.08
1.0
1.0
—
0.78
—
0
19
6
56
1.07
0.08
2.3
2.0
—
—
—
0
0
5
64
0.78
0.08
1.0
1.2
—
—
—
0
0
7
67
1.04
0.08
1.0
1.2
—
—
—
0
0
8
75
1.07
0.07
1.3
1.4
—
—
—
0
0
8
75
1.07
0.07
1.3
1.4
—
—
—
0
0
8
75
1.07
0.07
1.3
1.2
—
—
—
0
0
8
78
1.03
0.07
1.3
1.5
—
—
—
0
0
18
167
1.08
0.06
1.2
1.5
—
—
—
0
0
9
104
0.86
0.06
1.3
1.3
—
—
—
0
0
12
130
0.92
0.04
1.0
1.1
—
—
—
0
0
13
140
0.93
0.04
1.2
1.2
319.29
269.81
u/ml
—
7
73
24
229
1.05
0.04
1.9
1.7
22068.21
13337.05
e6/l
0.21
14
165
20
191
1.05
0.03
2.4
1.6
4.41
4.67
iu/l
—
7
55
11
117
0.94
0.02
6.3
5.8
9.43
12.46
mg/l
1.34
11
106
16
156
1.03
0.00
1.7
1.5
—
—
—
0
0
16
160
1.00
0.00
2.4
2.0
71.60
59.51
%
2.21
16
160
13
133
0.98
0.00
1.0
1.1
—
—
—
0
0
12
117
1.03
0.00
1.4
1.2
2.67
7.71
u/ml
—
6
49
15
147
1.02
0.00
1.1
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.06
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
8
89
0.90
-0.00
1.0
1.1
—
—
—
0
0
6
60
1.00
-0.00
2.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.05
—
0
6
5
52
0.96
-0.00
1.2
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
-0.00
1.3
1.7
—
—
—
0
0
9
96
0.94
-0.00
1.6
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
1.9
1.5
13.47
10.60
%
—
7
70
6
68
0.88
-0.00
1.2
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
15.8
—
126.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.6
—
0.27
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_ANUS_ANAL_CANAL and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_ANUS_ANAL_CANAL 1.11 [0.99, 1.24] 0.066
Birth year 0.998 [0.99, 1.01] 0.643

During the follow-up period (1.1.1998 — 31.12.2019), 811 out of 3244 females with CD2_BENIGN_ANUS_ANAL_CANAL died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_ANUS_ANAL_CANAL 1.233 [1.1, 1.39] < 0.001
Birth year 0.991 [0.98, 1.0] 0.046

During the follow-up period (1.1.1998 — 31.12.2019), 997 out of 2848 males with CD2_BENIGN_ANUS_ANAL_CANAL died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_ANUS_ANAL_CANAL.

N-year risk Females Males
1 0.12% 0.274%
5 0.735% 1.418%
10 1.683% 3.814%
15 3.423% 7.36%
20 6.062% 12.725%

Relationships between endpoints

Index endpoint: CD2_BENIGN_ANUS_ANAL_CANAL – Benign neoplasm: Anus and anal canal

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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