No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
375 |
4. Check minimum number of eventsNone |
375 |
5. Include endpointsNone |
375 |
6. Filter based on genotype QC (FinnGen only) |
375 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D80
- Name in latin
- Hypogammaglobulinaemia non familialis
Similar endpoints
↥List of similar endpoints to
Nonhereditary hypogammaglobulinemia
based on the number of shared cases.
Similar with more cases:
- Immunodeficiency with predominantly antibody defects
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1373 | 825 | 543 |
| Only index persons | 1282 | 786 | 496 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.05 | 52.53 | 46.32 |
| Only index persons | 49.45 | 52.05 | 45.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 375 | 246 | 129 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.06 |
| Median age at first event (years) | 51.28 | 50.81 | 52.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 333
- Matched controls
- 3328
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
323.0
328
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
181.3
157
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
177.4
154
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
96.7
88
*
ZX120
NOMESCO Finland
Intravenous
19.2
88.7
146
130
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
85.1
78
*
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
80.6
74
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
24.9
78.4
114
68
J18.9
ICD-10 Finland
Pneumonia, unspecified
10.8
77.9
185
346
J01MA14
ATC
moxifloxacin; systemic
16.8
74.1
127
118
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
24.1
73.6
108
65
J01MA12
ATC
levofloxacin; systemic
9.5
69.8
177
354
6BA02
NOMESCO Finland
NA
273.2
66.9
66
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
8.0
65.6
244
851
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
14.5
65.4
119
123
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
64.7
60
*
H02AB06
ATC
prednisolone; systemic
8.2
63.0
265
1073
WW200
NOMESCO Finland
Immunization
39.6
61.2
77
25
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
14.2
58.4
106
106
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
20.3
55.9
86
56
J47
ICD-10 Finland
Bronchiectasis
38.2
55.2
70
23
TPH04
NOMESCO Finland
Cathetrisation of vein
7.3
54.1
162
382
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
26.1
49.1
69
33
TDM10
NOMESCO Finland
Puncture of maxillary antrum
16.4
47.4
79
62
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
13.6
46.7
85
82
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.7
46.4
182
578
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
21.4
46.2
69
40
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.6
44.5
119
227
H02AB07
ATC
prednisone; oral
7.1
41.6
117
237
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
41.5
39
*
J01.0
ICD-10 Finland
Acute maxillary sinusitis
5.4
41.1
162
499
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
449.2
41.0
40
*
R50.9
ICD-10 Finland
Fever, unspecified
6.7
40.7
120
258
A49.9
ICD-10 Finland
Bacterial infection, unspecified
9.2
39.8
90
129
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
10.2
39.0
82
103
UGC12
NOMESCO Finland
Flexible bronchoscopy
11.4
38.7
76
84
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.8
38.0
180
659
C01CA24
ATC
epinephrine; parenteral
8.9
36.6
84
122
J45.1
ICD-10 Finland
Nonallergic asthma
9.5
36.6
80
107
H02AB09
ATC
hydrocortisone; systemic
25.9
36.6
51
23
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
5.6
34.9
121
310
TGC00
NOMESCO Finland
Bronchial lavation
24.6
33.3
47
22
J01FA06
ATC
roxithromycin; oral
4.1
32.3
210
981
Z01.8
ICD-10 Finland
Other specified special examinations
4.5
31.5
139
453
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
9.3
30.3
66
86
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
29.6
28
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
9.0
29.4
65
87
J01MA02
ATC
ciprofloxacin; systemic
3.8
29.3
183
802
R03BB04
ATC
tiotropium bromide; inhalant
7.3
28.5
73
123
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.8
28.0
242
1365
J45.9
ICD-10 Finland
Asthma, unspecified
4.5
27.5
115
347
L03AA02
ATC
filgrastim; parenteral
15.1
27.4
46
35
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
4.4
27.2
119
374
C03CA01
ATC
furosemide; systemic
4.4
26.9
117
365
J05AB11
ATC
valaciclovir; oral
5.2
26.9
94
234
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
65.6
26.4
30
5
R03AK06
ATC
salmeterol and fluticasone; inhalant
5.2
26.2
92
229
J45.0
ICD-10 Finland
Predominantly allergic asthma
6.2
26.2
76
151
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
3.5
26.1
217
1155
XW000
NOMESCO Finland
Bone marrow biopsy
12.5
25.3
46
42
JN4BD
NOMESCO Finland
Extensive body CT
6.1
25.0
74
150
M05BA04
ATC
alendronic acid; oral
7.2
24.7
63
104
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.4
24.6
56
78
J32.4
ICD-10 Finland
Chronic pansinusitis
25.1
24.4
34
15
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
60.9
24.4
28
5
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
9.2
23.8
51
64
J01FA10
ATC
azithromycin; systemic
3.6
23.6
255
1595
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.5
23.6
147
611
N02AX02
ATC
tramadol; systemic, rectal
3.3
23.3
180
878
J46
ICD-10 Finland
Status asthmaticus
14.6
23.1
39
30
R03BA02
ATC
budesonide; inhalant
4.0
22.7
106
345
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
18.8
22.3
34
20
ZX108
NOMESCO Finland
Inhalation
67.3
22.2
25
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.8
22.0
66
135
ZXA10
NOMESCO Finland
Bilateral
4.0
21.9
104
343
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.4
21.6
60
111
J45.8
ICD-10 Finland
Mixed asthma
13.7
21.4
37
30
A07AA02
ATC
nystatin; oral
6.9
21.1
55
93
R03DC03
ATC
montelukast; oral
3.9
21.0
100
329
UJF32
NOMESCO Finland
Coloscopy
3.4
20.8
127
509
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.7
20.8
63
130
R03BB01
ATC
ipratropium bromide; inhalant
11.5
20.8
39
38
GD1AD
NOMESCO Finland
Thorax CT examination
8.7
20.4
45
59
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
8.7
20.1
44
57
J01FA15
ATC
telithromycin; oral
4.7
20.1
75
195
WE300
NOMESCO Finland
Profylactive therapy of malignancy with biomoidiers
+∞
20.0
19
*
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
31.2
20.0
26
9
A03FA01
ATC
metoclopramide; systemic, rectal
3.6
19.9
108
393
R03AC02
ATC
salbutamol; inhalant
3.0
19.5
222
1342
R03AC12
ATC
salmeterol; inhalant
9.2
19.4
41
50
J01FF01
ATC
clindamycin; systemic
3.1
19.3
140
627
M04AA01
ATC
allopurinol; systemic
5.1
19.3
65
151
R03DA04
ATC
theophylline; systemic, rectal
8.1
19.3
44
61
ZX121
NOMESCO Finland
Central venous catheter
+∞
18.9
18
*
XG410
NOMESCO Finland
Flow-volume spirometry
9.1
18.9
40
49
J01AA02
ATC
doxycycline; systemic
3.7
18.1
289
2140
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
70.6
17.9
20
*
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
17.9
17
*
GD1DG
NOMESCO Finland
Extremely extensive MRI examination of pleura with high field magnet
+∞
17.9
17
*
WZC30
NOMESCO Finland
Teaching
4.1
17.7
77
230
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.0
17.6
77
231
A46
ICD-10 Finland
Erysipelas
4.2
17.5
73
210
N02AA05
ATC
oxycodone; systemic
4.2
17.3
72
206
L04AX01
ATC
azathioprine; systemic
7.8
17.2
40
57
D83.8
ICD-10 Finland
Other common variable immunodeficiencies
+∞
16.8
16
*
SPAT1262
SPAT
Handing over of treatment supplies
3.5
16.8
90
319
TAB00
NOMESCO Finland
Lumbar puncture
7.3
16.8
41
63
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
21.4
16.7
24
12
A41.9
ICD-10 Finland
Sepsis, unspecified
9.3
16.4
34
40
J02AC01
ATC
fluconazole; systemic
2.6
16.1
183
1051
TPX10
NOMESCO Finland
Implantation of vascular injection port
11.3
16.1
30
29
J01DA08
ATC
[U] cefaclor; oral
4.1
16.0
68
198
R01AD09
ATC
mometasone; nasal
2.6
15.9
194
1156
R01AD08
ATC
fluticasone; nasal
2.8
15.9
140
689
A02BC02
ATC
pantoprazole; systemic
2.8
15.9
243
1647
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
63.2
15.9
18
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
27.9
15.8
21
8
R06AE07
ATC
cetirizine; oral
2.6
15.5
184
1076
UJF30
NOMESCO Finland
Ileoscopy through colon
4.4
15.3
59
156
J01FA09
ATC
clarithromycin; systemic
2.7
15.2
146
755
JN4AD
NOMESCO Finland
Body CT examination
5.4
15.1
47
99
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
19.5
14.9
22
12
H02AB04
ATC
methylprednisolone; systemic
3.4
14.8
79
276
GD1CG
NOMESCO Finland
Extensive examination of lungs and pleura with high intensity magnet
+∞
14.7
14
*
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
9.3
14.6
30
35
D70.89
ICD-10 Finland
Neutropenic splenomegaly
28.7
14.4
19
7
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.2
14.4
89
345
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
6.0
14.3
40
74
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
10.1
14.3
28
30
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
44.6
14.2
17
*
A41.8
ICD-10 Finland
Other specified sepsis
16.7
14.1
22
14
R06.0
ICD-10 Finland
Dyspnoea
2.9
14.0
100
427
R03BA05
ATC
fluticasone; inhalant
3.0
14.0
94
385
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
21.2
14.0
20
10
A07AA09
ATC
vancomycin; oral
21.2
14.0
20
10
WW500
NOMESCO Finland
Blood transfusion
7.0
13.8
34
53
L03AA13
ATC
pegfilgrastim; parenteral
7.6
13.7
32
46
J01DA06
ATC
[U] cefuroxime; systemic
3.3
13.7
78
284
D80.6
ICD-10 Finland
Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
+∞
13.6
13
*
D83.1
ICD-10 Finland
Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
+∞
13.6
13
*
D84.18
ICD-10 Finland
Other specified defect in the complement system
+∞
13.6
13
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
13.6
13.6
23
18
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
145.7
13.5
14
*
J01DB01
ATC
cefalexin; oral
3.2
13.4
294
2330
XF400
NOMESCO Finland
ECG with 12 standard connections
3.3
13.3
74
266
WX892
NOMESCO Finland
Monitored bed care
4.8
13.2
45
105
H04.10
ICD-10 Finland
Dry eye syndrome
3.8
13.2
60
184
R4110
NOMESCO Finland
Physiotherapy
2.7
13.1
112
533
R03AK08
ATC
formoterol and beclometasone; inhalant
7.0
13.0
32
50
ZXA00
NOMESCO Finland
Right side
2.7
12.9
111
528
H65.2
ICD-10 Finland
Chronic serous otitis media
16.3
12.8
20
13
1XC02
NOMESCO Finland
NA
33.5
12.7
16
5
R03BA08
ATC
ciclesonide; inhalant
4.0
12.7
53
151
J31.0
ICD-10 Finland
Chronic rhinitis
4.2
12.6
49
130
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
25.5
12.6
17
7
D84.9
ICD-10 Finland
Immunodeficiency, unspecified
+∞
12.6
12
*
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
12.6
12
*
J06BA02
ATC
immunoglobulins, normal human, for intravascular adm.; systemic
+∞
12.6
12
*
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
134.9
12.5
13
*
A01AB09
ATC
miconazole; local oral
3.8
12.5
55
164
R01AD05
ATC
budesonide; nasal
4.1
12.4
50
138
B29
ICPC
Lymph/immune mech sympt/complt other
39.1
12.3
15
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
27.9
12.2
16
6
TQW99
NOMESCO Finland
Other minor procedure on skin
6.6
12.2
31
51
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
12.0
60
198
R03AC13
ATC
formoterol; inhalant
5.7
11.9
34
65
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.2
11.8
66
237
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
17.2
11.8
18
11
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
13.2
11.8
20
16
L01BB05
ATC
fludarabine; systemic
67.4
11.7
13
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.8
11.7
51
151
D70.82
ICD-10 Finland
Drug-induced neutropenia
14.3
11.6
19
14
N03AX16
ATC
pregabalin; oral
2.6
11.4
96
445
L04AA06
ATC
mycophenolic acid; systemic
11.1
11.4
21
20
R03AC03
ATC
terbutaline; inhalant
3.1
11.3
67
250
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
11.2
111
561
SPAT1255
SPAT
Intravenous administration of medicine
4.6
11.2
39
93
N03AX12
ATC
gabapentin; oral
3.0
11.1
69
264
J01.1
ICD-10 Finland
Acute frontal sinusitis
14.6
11.1
18
13
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
8.3
11.1
24
31
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.4
11.0
55
181
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
3.1
11.0
63
230
C10AC01
ATC
colestyramine; oral
9.3
10.9
22
25
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
11.1
10.9
20
19
ZXA05
NOMESCO Finland
Left side
2.5
10.9
100
486
R03DC01
ATC
zafirlukast; oral
10.1
10.9
21
22
WVC10
NOMESCO Finland
Subcutaneous infusion of drugs
29.1
10.8
14
5
N05CF01
ATC
zopiclone; oral
2.4
10.7
116
614
R81
ICPC
Pneumonia
6.3
10.7
28
48
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
62.0
10.7
12
*
C82.9
ICD-10 Finland
Follicular lymphoma, unspecified
62.0
10.7
12
*
R05
ICD-10 Finland
Cough
2.7
10.6
84
374
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.4
10.6
38
94
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.6
10.5
49
153
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
113.4
10.5
11
*
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
113.4
10.5
11
*
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
+∞
10.5
10
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
7.9
10.4
23
31
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
7.9
10.4
23
31
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.1
10.4
40
106
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.0
10.3
33
72
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.6
10.3
87
402
J05AB01
ATC
aciclovir; systemic
2.5
10.3
92
440
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
13.7
10.3
17
13
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.4
10.2
37
92
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
15.2
10.1
16
11
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
15.2
10.1
16
11
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.7
10.0
45
136
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
41.4
10.0
12
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
41.4
10.0
12
*
J01.4
ICD-10 Finland
Acute pansinusitis
17.4
10.0
15
9
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
6.2
9.9
26
45
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
26.9
9.9
13
5
A02BC05
ATC
esomeprazole; systemic
2.1
9.9
155
964
A28
ICPC
Limited function/disability NOS
3.3
9.8
51
173
ZX114
NOMESCO Finland
Intramuscular
13.9
9.8
16
12
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.0
9.7
59
223
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.3
9.7
50
169
I50.9
ICD-10 Finland
Heart failure, unspecified
4.0
9.6
39
108
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
15.6
9.6
15
10
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.6
9.6
43
130
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
6.5
9.6
24
39
J01DA01
ATC
[U] cefalexin; systemic
2.1
9.6
225
1648
A04AA01
ATC
ondansetron; systemic, rectal
3.8
9.6
40
114
A02BC01
ATC
omeprazole; systemic
2.3
9.5
105
555
J40
ICD-10 Finland
Bronchitis, not specified as acute or chronic
8.4
9.5
20
25
390
Kela drug reimbursment
Ibrutinib
102.8
9.5
10
*
L01XE27
ATC
[U] ibrutinib; oral
102.8
9.5
10
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.5
9.4
80
369
D84.1
ICD-10 Finland
Defects in the complement system
+∞
9.4
9
*
D81.0
ICD-10 Finland
Severe combined immunodeficiency [SCID] with reticular dysgenesis
+∞
9.4
9
*
S97
ICPC
Chronic ulcer skin
6.1
9.4
25
44
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
11.1
9.4
17
16
D64.9
ICD-10 Finland
Anaemia, unspecified
3.5
9.3
43
134
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.2
9.2
24
41
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.8
9.2
64
264
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.9
9.1
37
103
J32.8
ICD-10 Finland
Other chronic sinusitis
37.8
9.1
11
*
B01AB05
ATC
enoxaparin; parenteral
2.2
9.0
109
597
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.6
9.0
73
329
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.0
8.9
54
203
B99
ICD-10 Finland
Other and unspecified infectious diseases
9.9
8.9
17
18
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
4.9
8.8
28
61
JN3AD
NOMESCO Finland
Abdominal CT examination
3.6
8.8
39
117
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.1
8.8
128
761
R03AK07
ATC
formoterol and budesonide; inhalant
2.4
8.8
85
419
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.2
8.8
114
646
H66.0
ICD-10 Finland
Acute suppurative otitis media
3.6
8.7
39
118
A07EA06
ATC
budesonide; oral, local oral
5.4
8.7
25
49
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
5.4
8.7
25
49
N02BE01
ATC
paracetamol; systemic, rectal
2.6
8.7
293
2461
A04AA02
ATC
granisetron; systemic, transdermal
4.0
8.7
34
92
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.1
8.6
49
178
XQ800
NOMESCO Finland
Prick test
3.4
8.5
42
137
318
Kela drug reimbursment
Teriparatide
28.3
8.5
11
*
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
28.3
8.5
11
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
5.3
8.5
25
50
A01AB04
ATC
amphotericin B; local oral
4.3
8.5
31
78
E0000UV
ATC
NA
2.0
8.5
149
953
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
8.5
146
924
J20
ICD-10 Finland
Acute bronchitis
3.2
8.5
45
155
R1250
NOMESCO Finland
Evaluation of functional capability
8.2
8.5
18
23
UDM02
NOMESCO Finland
Sinoscopy
6.5
8.5
21
34
K90.0
ICD-10 Finland
Coeliac disease
6.5
8.5
21
34
1512
Kela drug reimbursment
Ibrutinib
92.3
8.5
9
*
ZX110
NOMESCO Finland
Intracutaneous
92.3
8.5
9
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
3.6
8.4
38
116
J33.8
ICD-10 Finland
Other polyp of sinus
8.9
8.4
17
20
R01AD12
ATC
fluticasone furoate; nasal
2.1
8.4
124
739
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
9.8
8.4
16
17
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
+∞
8.4
8
*
D81.1
ICD-10 Finland
Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
+∞
8.4
8
*
2790C
ICD-9 Finland
Disorders involving the immune mechanism, Deficiency of humoral immunity[DEFICIENTIA IMMUNOGLOBULINI ALIA]
+∞
8.4
8
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.6
8.3
64
280
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.1
8.2
46
164
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.5
8.2
71
331
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
12.1
8.1
14
12
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
12.1
8.1
14
12
P01AB01
ATC
metronidazole; oral, rectal
2.0
8.1
154
1008
B28
ICPC
Limited function/disability (B)
34.3
8.1
10
*
L01AA01
ATC
cyclophosphamide; systemic
34.3
8.1
10
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
8.1
70
325
A06AD11
ATC
lactulose; oral
2.8
8.1
53
209
ZX112
NOMESCO Finland
Subcutaneous
7.5
8.1
18
25
XA800
NOMESCO Finland
Neuropsychological investigation
4.6
8.0
27
63
XG466
NOMESCO Finland
Sleep oxymetry
5.7
8.0
22
41
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.5
8.0
36
110
M05BX04
ATC
denosumab; parenteral
4.7
8.0
26
59
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.1
7.9
24
50
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.6
7.9
35
105
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
8.8
7.9
16
19
212
Kela drug reimbursment
Gout
11.2
7.9
14
13
J01DC04
ATC
cefaclor; oral
9.8
7.9
15
16
C03DA01
ATC
spironolactone; oral
3.3
7.8
39
129
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
46.1
7.7
9
*
J32.1
ICD-10 Finland
Chronic frontal sinusitis
46.1
7.7
9
*
M81.9
ICD-10 Finland
Osteoporosis, unspecified
5.4
7.7
22
43
D07AB08
ATC
desonide; topical
3.1
7.7
43
153
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
8.3
7.7
16
20
N05CD07
ATC
temazepam; oral
2.8
7.7
49
192
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
12.2
7.6
13
11
H05AA02
ATC
teriparatide; parenteral
25.7
7.6
10
*
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
10.4
7.6
14
14
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
10.4
7.6
14
14
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.3
7.6
27
67
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.3
7.6
22
44
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.2
7.5
19
32
XG474
NOMESCO Finland
Exhalation nntrogen oxide
6.2
7.5
19
32
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.9
7.5
46
174
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
81.8
7.4
8
*
C82.01
ICD-10 Finland
Follicular nodular lymphoma, grade I
81.8
7.4
8
*
K90.9
ICD-10 Finland
Intestinal malabsorption, unspecified
81.8
7.4
8
*
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
81.8
7.4
8
*
R06AE09
ATC
levocetirizine; oral
2.4
7.4
68
322
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.0
7.4
42
151
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
9.7
7.4
14
15
E86
ICD-10 Finland
Volume depletion
9.7
7.4
14
15
E87.6
ICD-10 Finland
Hypokalaemia
5.7
7.3
20
37
D84.19
ICD-10 Finland
Unspecified defect in the complement system
+∞
7.3
7
*
4AA24
NOMESCO Finland
NA
+∞
7.3
7
*
D86.1
ICD-10 Finland
Sarcoidosis of lymph nodes
+∞
7.3
7
*
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
+∞
7.3
7
*
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
+∞
7.3
7
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.6
7.3
53
224
JN6AD
NOMESCO Finland
CT of torso and neck
16.2
7.3
11
7
P01BA02
ATC
hydroxychloroquine; oral
3.0
7.2
41
148
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
6.8
7.2
17
26
UDC00
NOMESCO Finland
Ear microscopy
3.3
7.2
35
114
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.3
7.2
35
114
D07AA02
ATC
hydrocortisone; topical
2.5
7.2
60
273
DPA30
NOMESCO Finland
Sphenotomy
30.7
7.2
9
*
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
30.7
7.2
9
*
X57
ICD-10 Finland
Unspecified privation
6.3
7.2
18
30
R03AK11
ATC
formoterol and fluticasone; inhalant
4.9
7.2
22
47
J01DC02
ATC
cefuroxime; systemic
3.6
7.2
31
92
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.8
7.1
45
174
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
12.4
7.1
12
10
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.7
7.1
48
194
L28
ICPC
Limited function/disability (L)
2.6
7.1
54
234
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
5.4
7.1
20
39
A02BC03
ATC
lansoprazole; oral
2.0
7.0
107
634
N03AX11
ATC
topiramate; oral
5.7
7.0
19
35
J01CA04
ATC
amoxicillin; systemic
2.2
7.0
279
2346
E000006
ATC
NA
3.4
7.0
33
105
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
7.8
7.0
15
20
5BA08
NOMESCO Finland
NA
14.2
6.9
11
8
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.7
6.9
22
49
WX882
NOMESCO Finland
High dependency care
5.9
6.9
18
32
J18.1
ICD-10 Finland
Lobar pneumonia, unspecified
11.3
6.8
12
11
J96.0
ICD-10 Finland
Acute respiratory failure
11.3
6.8
12
11
PJA10
NOMESCO Finland
Exploration of lymph nodes
9.6
6.8
13
14
R60.0
ICD-10 Finland
Localized oedema
3.0
6.8
39
142
D73.1
ICD-10 Finland
Hypersplenism
40.9
6.8
8
*
G72.9
ICD-10 Finland
Myopathy, unspecified
40.9
6.8
8
*
A49.8
ICD-10 Finland
Other bacterial infections of unspecified site
17.1
6.8
10
6
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
17.1
6.8
10
6
M05BA07
ATC
risedronic acid; oral
6.7
6.7
16
25
4222
FHL
Endonasal etmoidectomy
23.1
6.7
9
*
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
6.1
6.7
17
29
WX725
NOMESCO Finland
Noninvasive ventilation
3.7
6.7
28
81
C82.1
ICD-10 Finland
Follicular lymphoma grade II
12.6
6.6
11
9
R13
ICD-10 Finland
Dysphagia
3.4
6.6
30
93
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.3
6.5
32
105
WX872
NOMESCO Finland
Intensive care
4.0
6.5
25
67
UJD02
NOMESCO Finland
Gastroscopy
4.3
6.5
23
57
X58
ICD-10 Finland
Exposure to other specified factors
2.4
6.5
58
272
3XA02
NOMESCO Finland
NA
71.2
6.4
7
*
C83.1
ICD-10 Finland
Mantle cell lymphoma
71.2
6.4
7
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.8
6.4
15
23
L04AA01
ATC
[U] ciclosporin; systemic
6.2
6.4
16
27
ZXH06
SPAT
NA
6.2
6.4
16
27
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.5
6.4
21
49
WX002
NOMESCO Finland
Sedation and analgesia
2.1
6.4
74
394
Z31.5
ICD-10 Finland
Genetic counselling
3.8
6.3
25
69
R04
ICPC
Breathing problem other
5.0
6.3
19
40
2790B
ICD-9 Finland
Disorders involving the immune mechanism, Deficiency of humoral immunity[DEFICIENTIA IMMUNOGLOBULINI A]
+∞
6.3
6
*
L01AA02
ATC
chlorambucil; oral
+∞
6.3
6
*
D81.9
ICD-10 Finland
Combined immunodeficiency, unspecified
+∞
6.3
6
*
J01XB01
ATC
colistin; inhalant, parenteral
+∞
6.3
6
*
132
Kela drug reimbursment
Sarcoidosis
+∞
6.3
6
*
GD1BG
NOMESCO Finland
MRI of lungs and pleura with high intensity magnet
+∞
6.3
6
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.8
6.2
25
70
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.1
6.2
32
109
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
6.2
150
1041
H25.1
ICD-10 Finland
Senile nuclear cataract
2.2
6.2
63
314
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.0
6.2
23
60
R05
ICPC
Cough
2.0
6.2
82
460
N05BA01
ATC
diazepam; systemic, rectal
2.4
6.2
51
229
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
7.9
6.2
13
17
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
7.9
6.2
13
17
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
4.6
6.2
20
46
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
5.1
6.1
18
37
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.0
6.1
23
61
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
12.8
6.1
10
8
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
12.8
6.1
10
8
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
12.8
6.1
10
8
L04AA13
ATC
leflunomide; oral
5.4
6.1
17
33
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.4
6.1
28
88
N06AX21
ATC
duloxetine; oral
2.6
6.1
43
179
M35.7
ICD-10 Finland
Hypermobility syndrome
10.3
6.1
11
11
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
6.0
128
850
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
259
205
38.61
300.23
4.9
1.6
1.1
1.5
g/l
1.07
226
191
129
13
150.74
257.68
2.2
1.8
—
—
—
0
0
126
13
145.46
250.81
2.1
1.8
12.7
9.5
%
—
71
8
105
21
69.06
187.79
2.7
1.6
528.9
757.8
e6/l
0.57
91
15
103
20
70.62
185.17
2.8
1.6
0.2
0.2
e9/l
0.79
91
15
87
15
75.22
159.06
3.1
1.5
13.9
12.2
u/l
0.51
87
15
80
23
43.94
130.18
2.5
1.5
583.8
750.5
e6/l
0.58
29
11
270
693
11.34
119.31
4.7
1.4
1.3
2.4
g/l
14.49
207
431
89
63
18.21
101.53
2.6
1.8
—
—
—
0
0
140
203
10.41
99.45
1.9
1.2
65.4
265.4
u/ml
1.05
103
187
87
63
17.68
97.93
5.6
6.3
623.8
498.1
iu/ml
—
13
9
64
23
33.35
96.76
2.6
2.4
42.4
45.0
%
—
24
5
86
63
17.42
96.14
2.6
1.8
—
—
—
0
0
60
25
28.38
85.99
4.6
2.2
—
—
—
0
0
128
197
9.35
85.60
3.4
1.6
—
—
—
0
0
147
269
8.34
84.36
4.9
2.3
0.2
0.2
g/l
0.88
141
253
85
77
13.98
83.57
3.7
2.9
—
—
—
0
0
56
24
27.25
79.28
4.8
2.2
—
—
—
0
0
59
29
23.96
79.18
3.5
1.1
—
—
—
0
0
59
29
23.96
79.18
3.5
1.1
—
—
—
0
0
66
49
16.13
72.57
2.1
1.7
—
—
—
0
0
64
45
16.94
72.47
2.5
2.0
—
—
—
0
0
92
118
10.01
70.47
3.2
1.6
—
—
—
0
0
166
406
6.54
70.05
4.2
1.9
—
—
—
0
0
77
78
12.16
69.95
1.8
1.1
—
—
—
0
0
44
22
22.53
58.20
2.3
2.1
—
—
—
0
0
44
22
22.53
58.20
2.3
2.1
—
—
—
0
0
44
22
22.53
58.20
2.3
2.1
—
—
—
0
0
65
67
11.53
57.99
3.5
1.4
—
—
—
0
0
53
42
14.53
55.77
2.2
1.7
—
—
—
0
0
51
39
14.98
54.74
1.9
1.8
—
—
—
0
0
121
281
5.88
52.33
3.6
1.8
—
—
—
0
0
66
86
9.10
49.21
2.9
2.1
1.3
1.6
ug/l
0.12
60
81
45
34
14.90
48.49
2.2
1.8
—
—
—
0
0
115
283
5.42
46.07
3.9
1.9
—
—
—
0
0
40
27
16.46
45.75
1.8
1.9
—
—
—
0
0
43
35
13.75
44.30
2.3
1.8
—
—
—
0
0
30
11
29.56
44.24
4.2
1.4
—
—
—
0
0
30
12
27.09
42.93
2.7
2.2
—
—
—
0
0
29
11
28.49
42.24
2.7
2.3
—
—
—
0
0
29
11
28.49
42.24
2.7
2.3
—
—
—
0
0
43
41
11.72
40.04
4.5
1.5
—
—
—
0
0
43
41
11.72
40.04
4.5
1.5
—
—
—
0
0
43
41
11.72
40.04
4.5
1.5
—
—
—
0
0
43
42
11.43
39.39
4.5
1.5
—
—
—
0
0
43
42
11.43
39.39
4.5
1.5
—
—
—
0
0
43
42
11.43
39.39
4.5
1.5
—
—
—
0
0
30
15
21.65
39.34
2.7
2.0
—
—
—
0
0
30
15
21.65
39.34
2.7
2.0
—
—
—
0
0
30
15
21.65
39.34
2.7
2.0
—
—
—
0
0
30
15
21.65
39.34
2.7
2.0
—
—
—
0
0
258
1287
4.22
38.47
4.8
2.3
80.4
76.3
nmol/l
1.57
246
1155
27
11
26.37
38.28
1.6
1.5
—
—
—
0
0
174
668
3.99
38.07
3.5
2.0
3.3
3.0
mg/l
1.29
169
575
62
101
7.16
37.79
2.5
2.3
1.4
1.5
g/l
0.41
55
91
118
364
4.27
34.71
3.2
2.2
20.6
23.6
%
1.21
106
318
44
54
9.10
34.05
1.7
1.5
—
—
—
0
0
86
217
4.84
32.62
3.5
2.7
62.2
67.5
g/l
5.97
80
203
23
11
22.21
30.52
1.8
1.0
—
—
—
0
0
259
1427
3.63
30.35
19.2
6.5
1.2
1.2
mmol/l
0.73
233
1211
241
1292
3.42
29.06
18.7
6.0
1.2
1.2
mmol/l
1.88
234
1183
43
62
7.70
29.04
2.4
1.8
—
—
—
0
0
22
11
21.18
28.62
1.9
1.0
—
—
—
0
0
40
56
7.88
27.68
8.6
3.6
53.8
56.7
%
0.46
40
56
124
458
3.55
27.33
8.3
3.5
0.8
0.8
mmol/l
0.36
118
431
25
18
14.81
27.32
1.1
8.0
—
41.7
u/ml
—
0
7
340
2333
5.90
27.15
16.0
3.9
13.9
11.0
mm/h
2.90
334
2156
92
288
3.91
25.83
4.3
2.0
283.0
368.7
nmol/l
4.06
84
259
50
96
5.86
25.61
1.6
1.4
333.5
289.2
ug/g
0.78
39
55
23
18
13.55
23.92
1.6
1.2
—
—
—
0
0
65
167
4.50
23.72
2.2
1.3
—
—
—
0
0
28
31
9.68
23.25
2.5
1.8
—
—
—
0
0
95
326
3.56
23.08
17.1
7.0
103.7
104.1
mmol/l
0.35
95
316
19
11
18.14
23.05
1.2
1.1
—
—
—
0
0
201
1067
2.90
22.83
7.5
3.2
43.0
32.8
u/l
0.68
196
1019
47
98
5.34
21.94
6.2
1.9
—
—
—
0
0
77
237
3.83
21.92
14.1
3.7
1.7
2.3
mmol/l
0.60
68
190
35
56
6.79
21.40
1.7
2.4
143.8
132.8
g/l
—
9
40
18
11
17.14
21.24
2.9
1.8
80.5
68.1
ug/l
0.24
18
11
193
1036
2.78
20.95
7.8
3.0
—
—
—
0
0
47
103
5.07
20.71
4.6
2.1
—
—
—
0
0
31
45
7.42
20.68
1.6
1.4
—
—
—
0
0
31
45
7.42
20.68
1.6
1.4
—
—
—
0
0
31
45
7.42
20.68
1.4
1.3
—
—
—
0
0
152
729
2.82
20.42
4.2
2.9
1415.5
830.0
ng/l
0.71
144
601
39
73
5.85
20.42
1.6
1.5
—
—
—
0
0
18
12
15.71
20.33
5.3
1.5
20.3
32.2
umol/l
2.14
18
12
25
29
9.17
20.00
4.4
3.9
—
—
—
0
0
268
1730
2.92
19.87
13.4
4.8
6.8
6.5
mmol/l
0.59
258
1612
227
1354
2.71
19.53
4.4
2.7
195.4
102.8
ug/l
2.53
221
1254
31
48
6.95
19.50
1.4
1.5
—
—
—
0
0
23
5
48.79
19.42
1.3
1.0
97.2
89.4
%
—
23
5
23
5
48.79
19.42
1.3
1.0
—
—
—
0
0
71
228
3.61
18.84
16.7
8.2
1.3
1.3
mmol/l
0.03
65
218
89
333
3.19
18.49
5.0
3.0
7.6
7.6
umol/l
0.01
81
290
58
165
3.98
18.32
7.5
3.7
1.9
1.7
mmol/l
0.08
44
124
60
176
3.87
18.14
7.7
3.6
5.2
5.2
kpa
0.04
54
166
25
33
8.05
18.04
1.6
1.2
—
—
—
0
0
22
25
9.29
17.83
1.7
1.0
0.5
0.1
u/ml
—
13
10
38
80
5.17
17.47
4.2
3.4
28.0
27.7
mg/l
0.01
30
65
38
80
5.17
17.47
4.2
3.3
30.9
128.6
mg/l
0.67
30
66
18
16
11.77
17.22
1.9
1.4
—
—
—
0
0
18
16
11.77
17.22
1.9
1.4
—
—
—
0
0
19
19
10.48
16.83
1.2
1.2
—
—
—
0
0
76
280
3.15
16.05
15.7
10.5
10.7
12.3
kpa
2.67
67
270
76
280
3.15
16.05
15.7
10.5
5.0
5.2
kpa
0.62
68
269
36
78
5.00
16.00
4.4
3.4
3.2
2.7
ratio
—
5
11
136
683
2.56
15.94
2.9
1.7
1.5
1.1
mg/l
0.30
116
527
76
282
3.13
15.85
15.9
10.5
0.6
1.4
mmol/l
0.63
56
224
15
0
+∞
15.73
1.7
0.0
2.1
—
mg/l
—
7
0
15
0
+∞
15.73
1.7
0.0
0.7
—
mg/l
—
6
0
15
0
+∞
15.73
1.7
0.0
0.2
—
mg/l
—
5
0
15
0
+∞
15.73
1.7
0.0
5.5
—
mg/l
—
6
0
15
0
+∞
15.73
1.7
0.0
0.2
—
mg/l
—
5
0
15
0
+∞
15.73
1.7
0.0
0.2
—
mg/l
—
7
0
15
0
+∞
15.73
1.7
0.0
0.2
—
mg/l
—
6
0
15
0
+∞
15.73
1.7
0.0
0.4
—
mg/l
—
6
0
15
0
+∞
15.73
1.7
0.0
0.4
—
mg/l
—
6
0
15
0
+∞
15.73
1.7
0.0
0.6
—
mg/l
—
6
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
34
72
5.09
15.50
12.3
3.6
0.4
0.3
u/ml
0.16
28
38
161
885
2.44
15.41
4.4
2.1
114.7
237.6
u/l
0.98
154
845
46
128
3.96
14.90
1.6
1.2
2.6
4.5
u/ml
—
14
6
30
59
5.44
14.84
1.4
1.4
84.8
110.1
u/ml
1.10
13
12
49
145
3.74
14.54
2.9
1.8
—
—
—
0
0
147
796
2.39
14.34
6.5
2.9
0.2
0.5
e6/l
1.08
128
570
18
21
8.95
14.24
1.4
1.2
—
—
—
0
0
17
19
9.32
13.87
1.2
1.7
—
—
—
0
0
15
14
11.12
13.83
2.7
1.9
—
—
—
0
0
18
22
8.54
13.74
2.7
1.7
—
—
—
0
0
37
93
4.30
13.70
1.8
1.5
0.0
0.0
iu/ml
—
9
17
276
1988
2.47
13.48
9.4
4.0
273.4
1028.8
e6/l
—
5
35
138
748
2.34
13.23
7.5
2.6
333.9
6682.8
umol/l
3.10
130
659
100
472
2.53
13.01
2.0
1.6
1353.9
1168.9
nmol/l
1.23
87
352
21
33
6.68
12.96
1.7
1.2
—
—
—
0
0
33
80
4.43
12.78
1.7
1.3
2.0
1.0
u/ml
—
11
6
42
122
3.75
12.77
3.6
2.1
—
—
—
0
0
38
103
3.99
12.73
4.0
1.6
2.9
3.1
g/l
0.49
24
86
48
155
3.40
12.45
20.5
10.8
24.7
24.9
mmol/l
0.10
42
146
18
25
7.51
12.37
3.6
2.1
—
—
—
0
0
39
110
3.84
12.36
3.9
1.6
2.6
3.9
g/l
6.53
24
85
39
110
3.84
12.36
3.9
1.6
7.2
7.5
g/l
0.50
25
89
39
110
3.84
12.36
3.9
1.6
—
—
—
0
0
14
14
10.35
12.30
1.1
1.1
—
—
—
0
0
129
702
2.28
12.06
3.8
2.2
—
—
—
0
0
212
1407
2.17
12.01
8.1
4.0
—
—
—
0
0
20
33
6.35
11.78
1.5
1.2
57.7
59.2
u/l
0.04
13
22
14
15
9.66
11.72
2.9
1.8
—
—
—
0
0
24
48
5.27
11.63
1.8
1.3
42.6
75.1
u/ml
—
6
5
15
18
8.64
11.57
2.7
1.8
—
—
—
0
0
111
577
2.31
11.49
1.8
1.7
485.7
440.0
pmol/l
1.08
104
481
13
13
10.32
11.40
1.0
1.0
—
—
—
0
0
15
6
25.94
11.22
1.1
3.8
—
—
—
0
0
36
103
3.76
11.17
1.8
1.3
2.3
2.8
u/ml
0.18
11
15
36
104
3.72
11.02
1.7
1.3
1.8
7.1
u/ml
0.70
12
21
37
111
3.59
10.71
1.7
1.3
6.4
2.0
u/ml
—
7
7
31
83
3.98
10.54
1.7
1.2
20.5
34.3
u/ml
—
11
9
27
65
4.40
10.54
1.3
1.2
—
—
—
0
0
12
12
10.30
10.49
1.0
1.2
—
—
—
0
0
15
8
19.46
10.34
1.1
1.5
—
—
—
0
0
174
1128
2.01
9.88
2.5
1.8
94.0
96.6
pmol/l
0.34
118
562
13
16
8.38
9.79
1.8
1.4
—
—
—
0
0
13
16
8.38
9.79
1.8
1.4
—
—
—
0
0
14
19
7.62
9.76
4.9
4.4
—
—
—
0
0
17
29
6.09
9.68
3.7
2.2
33.8
32.6
pg
0.56
17
29
38
124
3.30
9.67
21.2
3.6
24.8
24.6
mmol/l
0.18
30
112
115
645
2.13
9.65
2.3
1.4
21.1
21.8
nmol/l
0.20
110
545
18
33
5.68
9.54
1.1
1.1
—
—
—
0
0
25
62
4.25
9.40
1.3
1.3
233.3
257.1
u/ml
0.15
18
34
135
817
2.02
9.15
7.3
3.5
0.0
0.0
estimate
0.00
54
281
215
1527
1.96
9.13
6.1
3.3
0.0
0.0
estimate
0.00
50
283
46
175
2.86
9.01
4.1
2.2
165.6
128.8
ng/l
0.24
35
157
13
7
19.17
8.99
5.5
5.4
—
—
—
0
0
29
84
3.66
8.83
1.2
1.1
—
—
—
0
0
32
101
3.37
8.57
4.2
1.6
7.8
10.3
g/l
2.10
24
92
13
19
7.05
8.49
1.3
1.0
—
—
—
0
0
214
1543
1.90
8.41
7.5
4.5
0.0
0.0
estimate
0.00
54
287
215
1558
1.89
8.26
6.1
3.3
0.0
0.0
estimate
0.50
53
272
13
9
14.90
8.26
1.2
2.1
—
—
iu/ml
—
0
0
62
287
2.39
8.16
2.6
2.4
31.5
29.0
u/l
0.21
56
242
13
20
6.70
8.12
2.7
3.4
—
—
—
0
0
13
20
6.70
8.12
1.5
1.3
42892.9
8272.5
e6/l
—
7
8
11
14
8.06
8.03
3.9
2.1
—
—
—
0
0
11
14
8.06
8.03
3.9
2.1
—
—
—
0
0
16
31
5.35
8.00
1.2
1.3
—
—
—
0
0
28
86
3.44
7.82
1.6
1.3
—
—
—
0
0
10
12
8.53
7.61
1.1
1.2
—
—
—
0
0
93
522
2.04
7.58
5.3
3.4
89.8
220.5
ng/l
1.05
70
368
160
1079
1.84
7.51
5.9
3.3
24.5
32.8
ng/l
0.63
120
681
53
238
2.43
7.44
2.9
2.4
68.1
69.2
ml/min/173m2
0.05
20
101
13
22
6.09
7.43
1.8
1.6
1.2
3.4
u/l
—
6
12
356
3164
3.47
7.26
55.7
12.2
17.3
21.5
mg/l
3.01
345
2413
152
1020
1.82
7.17
6.2
3.3
2.3
2.4
mmol/l
3.39
140
889
22
64
3.59
6.67
1.5
1.3
—
—
—
0
0
6
0
+∞
6.26
1.2
0.0
—
—
—
0
0
14
30
4.81
6.26
1.1
1.1
—
—
—
0
0
14
30
4.81
6.26
1.1
1.1
—
—
—
0
0
34
134
2.69
6.23
11.1
11.7
24.3
24.6
mmol/l
0.18
28
125
14
31
4.65
6.03
1.1
1.1
—
—
—
0
0
83
485
1.91
5.91
5.1
2.5
1.1
1.0
e6/l
0.14
58
249
14
33
4.37
5.60
1.0
1.1
—
—
—
0
0
55
283
2.11
5.57
4.0
3.2
—
—
—
0
0
17
47
3.74
5.54
1.2
1.1
—
—
—
0
0
5
0
+∞
5.22
1.4
0.0
—
—
—
0
0
162
1196
1.62
4.94
6.7
3.4
—
—
—
0
0
12
29
4.24
4.66
1.6
1.2
—
—
—
0
0
16
48
3.44
4.66
1.0
1.3
0.5
0.5
nmol/l
0.20
16
43
9
11
8.35
4.58
1.0
1.1
1132.8
1749.6
miu/ml
—
9
11
10
21
4.86
4.56
3.1
2.4
102.2
94.1
%
—
10
21
8
8
10.18
4.54
1.1
1.3
—
—
—
0
0
11
27
4.17
4.19
1.1
1.1
—
—
—
0
0
72
454
1.73
3.92
6.1
2.7
2.6
3.2
e6/l
0.32
47
223
257
2186
1.56
3.83
4.6
3.2
—
—
—
0
0
287
3156
0.61
3.70
4.4
4.3
4.7
4.8
mmol/l
1.00
275
2945
286
3144
0.62
3.60
4.3
4.2
1.5
1.5
mmol/l
0.81
274
2922
328
2980
1.80
3.56
34.5
11.4
85.1
85.2
ml/min/173m2
0.01
309
2410
9
17
5.40
3.53
1.4
1.5
0.7
1.2
u/field
—
9
12
107
765
1.56
3.52
1.4
1.3
0.8
1.8
u/ml
0.85
22
212
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
13
6.26
3.52
1.0
1.2
—
—
—
0
0
14
48
2.99
3.33
1.5
1.4
0.3
0.3
nmol/l
—
9
37
7
11
6.46
3.20
1.0
1.0
—
—
—
0
0
14
50
2.87
3.12
1.2
1.2
1.3
1.7
u/ml
—
6
14
24
113
2.20
3.07
1.7
1.2
—
—
—
0
0
84
586
1.56
3.04
1.3
1.3
5.7
10.2
u/ml
0.68
34
238
24
114
2.18
3.01
1.7
1.2
—
—
—
0
0
5
5
10.11
2.98
2.8
1.4
48.2
36.6
umol/l
—
5
5
5
5
10.11
2.98
2.8
1.8
—
—
—
0
0
5
5
10.11
2.98
1.0
1.6
—
—
—
0
0
277
3035
0.67
2.88
4.2
3.8
1.4
1.3
mmol/l
2.21
267
2810
84
593
1.54
2.88
1.4
1.3
15.1
35.0
iu/ml
2.87
20
188
296
3199
0.65
2.86
4.8
4.7
2.7
2.9
mmol/l
2.39
282
2967
24
117
2.12
2.84
1.5
2.3
5228.0
4465.3
u/l
—
8
41
14
53
2.71
2.82
1.1
1.1
—
—
—
0
0
14
54
2.65
2.73
1.1
1.2
2.3
3.8
u/ml
—
6
23
49
307
1.69
2.73
3.4
4.1
3.8
6.6
ug/l
0.90
39
254
6
10
6.08
2.71
2.8
2.1
—
—
—
0
0
6
10
6.08
2.71
1.2
1.3
—
—
—
0
0
277
2472
1.46
2.65
5.1
3.9
15.1
14.6
pmol/l
2.86
264
2258
6
11
5.52
2.55
7.0
4.4
192.3
214.9
u/l
—
6
11
15
316
0.45
2.44
1.2
1.7
—
—
—
0
0
89
666
1.44
2.27
1.7
1.5
—
—
—
0
0
13
54
2.46
2.22
2.1
1.4
—
—
—
0
0
21
108
2.00
2.20
1.9
1.2
—
—
—
0
0
8
25
3.25
2.10
1.0
1.4
—
—
—
0
0
5
11
4.59
1.94
3.0
1.1
4.2
7.1
umol/l
—
5
11
108
859
1.36
1.91
4.8
4.0
36.4
10.9
mg/mmol
1.16
70
530
12
52
2.35
1.89
1.8
1.1
105.2
10.5
iu/ml
—
6
11
8
28
2.90
1.87
1.4
1.1
—
—
—
0
0
8
28
2.90
1.87
1.4
1.1
—
—
—
0
0
6
17
3.57
1.84
1.2
1.2
—
1.1
—
0
5
5
12
4.21
1.83
1.0
1.4
—
—
—
0
0
35
225
1.61
1.81
1.3
1.3
—
35.8
—
0
11
8
29
2.80
1.80
1.4
1.1
—
—
—
0
0
8
29
2.80
1.80
1.4
1.1
—
—
—
0
0
8
29
2.80
1.80
1.4
1.1
—
—
—
0
0
21
119
1.81
1.70
1.5
1.5
—
—
—
0
0
20
112
1.83
1.68
1.1
1.4
422.9
247.2
miu/ml
—
8
58
7
25
2.83
1.65
1.4
1.7
0.4
3.1
u/field
—
7
11
70
532
1.39
1.63
3.7
2.6
2.5
2.4
mmol/l
0.53
62
467
5
17
2.97
1.36
2.8
2.6
23.0
29.5
umol/l
—
5
11
8
38
2.13
1.19
1.6
3.0
2.5
3.2
nmol/l
—
8
38
29
201
1.48
1.14
2.1
2.7
55.8
45.6
u/ml
0.19
29
196
26
178
1.49
1.08
1.5
2.1
—
—
—
0
0
10
52
1.95
1.07
1.2
1.1
—
—
—
0
0
28
198
1.45
1.01
1.7
1.3
—
—
—
0
0
7
127
0.54
0.90
1.1
1.4
—
—
—
0
0
51
411
1.28
0.84
1.9
1.9
1.8
1.4
%
1.64
45
372
306
2934
1.23
0.83
6.1
4.6
1.9
1.9
mu/l
0.68
294
2700
8
46
1.75
0.83
7.9
5.3
337.3
359.8
umol/l
—
8
40
0
26
0.00
0.78
0.0
1.1
—
—
—
0
0
5
27
1.86
0.68
9.0
18.3
1496.8
1561.4
nmol/l
—
5
27
28
360
0.76
0.68
10.3
6.1
—
—
—
0
0
46
380
1.24
0.64
2.0
2.0
—
—
—
0
0
8
54
1.49
0.57
1.4
1.5
35.4
23.8
u/l
—
8
45
297
3063
0.85
0.57
5.0
4.3
5.9
5.9
mmol/l
0.02
286
2824
29
231
1.28
0.56
1.7
2.1
—
—
—
0
0
286
2953
0.87
0.53
47.4
13.0
39.0
40.5
%
2.90
215
2239
12
85
1.43
0.47
2.9
1.8
—
—
—
0
0
48
414
1.18
0.46
2.2
2.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
—
—
0
0
9
71
1.27
0.36
1.2
1.6
223.6
234.5
pmol/l
—
9
66
30
255
1.19
0.35
1.3
1.2
74.1
147.3
iu/ml
1.10
14
104
281
2881
0.90
0.35
6.2
5.3
39.9
39.2
mmol/mol
0.42
269
2692
6
44
1.37
0.34
2.5
2.3
13.9
13.2
%
—
6
44
5
73
0.68
0.26
1.8
1.6
—
—
—
0
0
21
180
1.18
0.24
1.1
1.0
—
—
—
0
0
12
146
0.82
0.22
2.8
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
64
602
1.08
0.18
1.7
1.4
—
—
—
0
0
10
82
1.23
0.17
1.7
1.2
—
—
—
0
0
53
565
0.93
0.16
4.3
4.1
18.7
21.8
%
0.92
31
246
7
82
0.85
0.07
1.7
1.6
—
—
—
0
0
85
864
0.98
0.04
1.5
1.6
1.3
1.4
mmol/l
0.40
77
736
41
418
0.98
0.01
2.8
2.8
0.7
0.7
ug/l
0.02
33
255
12
126
0.95
0.00
2.7
1.7
—
—
—
0
0
356
3559
1.01
0.00
68.3
18.3
130.0
136.4
g/l
11.64
356
3504
0
9
0.00
0.00
0.0
1.0
—
22.8
—
0
9
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
75
0.93
0.00
1.4
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
7
75
0.93
0.00
1.4
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
75
0.93
0.00
1.4
1.5
—
—
—
0
0
5
55
0.91
0.00
1.6
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
0.00
1.6
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_NONHEREDHYPOGAMMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_NONHEREDHYPOGAMMA | 3.869 [3.03, 4.95] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.063 |
During the follow-up period (1.1.1998 — 31.12.2019), 147 out of 714 females with D3_NONHEREDHYPOGAMMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_NONHEREDHYPOGAMMA | 3.065 [2.24, 4.19] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 457 males with D3_NONHEREDHYPOGAMMA died.
Mortality risk
Mortality risk for people of age
years, who have D3_NONHEREDHYPOGAMMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.361% | 0.457% |
| 5 | 2.14% | 3.087% |
| 10 | 5.093% | 8.232% |
| 15 | 9.046% | 16.041% |
| 20 | 15.845% | 25.789% |
Relationships between endpoints
↥Index endpoint: D3_NONHEREDHYPOGAMMA – Nonhereditary hypogammaglobulinemia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data