Other nutritional anaemias

D3_NUTRIANAEMIAOTHER

anemia (phenotype): ['A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin.']

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D53
  • Hospital discharge: ICD-9 281[8-9]
  • Hospital discharge: ICD-8 281[3-9]
  • Cause of death: ICD-10 D53
  • Cause of death: ICD-9 281[8-9]
  • Cause of death: ICD-8 281[3-9]

2 out of 7 registries used, show all original rules.

372

4. Check minimum number of events

None

372

5. Include endpoints

None

372

6. Filter based on genotype QC (FinnGen only)

372

Control definitions (FinnGen only)

Control exclude
D3_NUTRIANAEMIA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D50-D53
Name in latin
Aliae anaemiae nutritionales

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6137 3333 2692
Only index persons 3304 1855 1449
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.08
Only index persons 0.06 0.07 0.06
Median age at first event (years)
Whole population 68.88 69.46 68.16
Only index persons 62.81 61.05 65.05

-FinnGen-

Key figures

All Female Male
Number of individuals 372 175 197
Unadjusted period prevalence (%) 0.07 0.06 0.09
Median age at first event (years) 63.46 58.15 68.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
343
Matched controls
3440
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
2738.5
252.2
213
*
D64.9
ICD-10 Finland
Anaemia, unspecified
11.1
63.3
134
186
D53.9
ICD-10 Finland
Nutritional anaemia, unspecified
+∞
60.2
56
*
107
Kela drug reimbursment
Pernicious anaemia
+∞
56.9
53
*
B03BA03
ATC
hydroxocobalamin; parenteral
16.2
51.3
86
69
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
33.9
43.8
57
20
28199
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Other and unspecified deficiency anaemia
+∞
30.7
29
*
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
+∞
29.6
28
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.8
26.9
149
574
B81
ICPC
Anaemia vit B12/folate deficiency
12.5
25.3
46
42
K29.4
ICD-10 Finland
Chronic atrophic gastritis
18.1
23.3
36
22
XW000
NOMESCO Finland
Bone marrow biopsy
10.6
22.9
45
48
2819X
ICD-9 Finland
Other deficiency anaemias, Unspecified deficiency anaemia
+∞
16.8
16
*
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
44.5
14.2
17
*
C03CA01
ATC
furosemide; systemic
2.4
13.1
164
951
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
21.0
12.6
18
9
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.4
11.8
35
70
WW500
NOMESCO Finland
Blood transfusion
6.2
11.6
31
54
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
20.9
11.2
16
8
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
9.8
59
221
M04AA01
ATC
allopurinol; systemic
2.7
9.8
72
306
R53
ICD-10 Finland
Malaise and fatigue
2.3
8.9
92
464
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.4
8.5
41
131
28198
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Alia definita
+∞
8.4
8
*
D53.8
ICD-10 Finland
Other specified nutritional anaemias
+∞
8.4
8
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
8.3
124
740
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
8.8
7.9
16
19
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
7.7
120
720
I50.9
ICD-10 Finland
Heart failure, unspecified
2.2
7.7
81
414
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
7.6
67
313
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
7.4
53
222
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
9.7
7.3
14
15
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.9
7.2
19
34
J01MA12
ATC
levofloxacin; systemic
2.3
7.1
73
367
R55
ICD-10 Finland
Syncope and collapse
2.6
6.9
51
217
N06AB04
ATC
citalopram; systemic
2.2
6.9
77
401
D52.9
ICD-10 Finland
Folate deficiency anaemia, unspecified
40.9
6.8
8
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.8
6.5
26
72
B03XA01
ATC
erythropoietin; parenteral
14.7
6.4
10
7
N19
ICD-10 Finland
Unspecified kidney failure
4.0
6.3
24
64
28110
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Other vitamin B12 deficiency
+∞
6.3
6
*
UJF32
NOMESCO Finland
Coloscopy
2.0
6.2
92
535
E87.6
ICD-10 Finland
Hypokalaemia
4.6
6.1
20
46

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
76
118
7.83
48.79
3.0
2.1
1.3
1.6
g/l
1.51
60
104
122
306
5.44
47.93
5.9
2.5
2.2
1.7
%
1.46
107
279
101
224
5.81
45.38
5.8
2.6
70.0
66.7
e9/l
0.22
81
179
115
368
4.07
31.84
3.4
2.3
2.2
2.2
g/l
0.50
106
338
120
402
3.92
31.04
3.5
2.3
13.9
12.8
umol/l
0.57
108
368
107
346
3.93
28.91
3.6
2.4
27.1
22.7
%
1.07
89
290
157
657
3.40
28.49
2.9
1.9
3.3
3.1
mg/l
0.22
130
553
132
546
3.19
23.71
2.2
1.8
1356.9
1195.5
nmol/l
1.08
99
403
183
980
2.70
19.60
4.5
2.5
241.1
131.0
ug/l
2.96
164
881
29
48
6.46
17.08
1.4
1.5
—
—
—
0
0
84
331
2.98
15.74
8.7
5.7
1.1
1.0
mmol/l
0.20
79
300
20
24
8.74
15.49
1.1
1.3
—
—
—
0
0
38
92
4.48
14.74
2.0
3.5
33.4
29.0
mg/l
0.32
28
71
38
92
4.48
14.74
1.9
3.5
41.5
141.5
mg/l
0.77
28
71
31
64
5.19
14.51
1.5
4.2
—
—
—
0
0
183
1100
2.30
13.87
2.9
2.0
89.8
94.3
pmol/l
0.64
115
542
127
653
2.43
13.80
2.2
1.6
19.5
21.2
nmol/l
0.56
114
542
145
795
2.35
13.58
5.9
4.3
—
—
—
0
0
142
790
2.29
12.69
7.8
5.4
—
—
—
0
0
55
192
3.18
12.56
1.9
2.3
—
—
—
0
0
61
229
2.99
12.30
1.9
2.8
66.1
65.7
g/l
0.13
56
201
18
26
7.21
11.94
1.4
1.1
—
—
—
0
0
188
1222
2.08
10.88
9.1
5.5
0.0
0.0
e9/l
3.05
169
1074
187
1218
2.07
10.71
9.1
5.5
0.6
0.6
e9/l
0.10
168
1067
192
1266
2.06
10.60
9.5
5.7
0.2
0.2
e9/l
0.27
173
1127
179
1152
2.06
10.55
10.3
5.9
8.7
8.7
%
0.02
164
1072
181
1174
2.05
10.40
9.9
5.8
25.7
26.7
%
0.56
165
1087
189
1247
2.04
10.34
9.2
5.6
1.7
1.9
e9/l
0.86
168
1120
174
1116
2.05
10.28
9.6
5.7
0.6
0.6
%
0.46
160
1038
177
1143
2.04
10.25
9.8
5.6
2.8
2.8
%
0.14
163
1058
18
33
5.67
9.52
1.8
1.4
—
—
—
0
0
47
176
2.91
9.45
2.9
3.6
5.1
5.2
kpa
0.19
42
162
82
410
2.28
9.07
1.7
1.6
2.9
2.3
g/l
1.20
46
242
174
1157
1.94
8.91
9.6
5.7
58.4
58.3
%
0.01
158
1082
36
120
3.21
8.83
2.9
3.7
—
—
—
0
0
196
1377
1.89
8.30
8.4
5.8
12.4
11.8
umol/l
0.20
178
1300
50
208
2.62
8.22
6.0
3.7
108.1
79.7
ng/l
0.89
42
183
171
1158
1.88
8.05
7.3
4.4
33.7
35.1
g/l
2.17
160
1066
67
325
2.29
7.90
6.2
7.8
1.2
1.5
mmol/l
0.19
52
251
51
220
2.52
7.78
9.8
7.9
—
—
—
0
0
188
1322
1.85
7.77
11.3
6.8
1.2
1.2
mmol/l
1.14
156
1114
127
804
1.88
7.21
4.1
2.5
—
—
—
0
0
36
135
2.84
7.21
8.4
11.7
—
—
—
0
0
42
176
2.56
6.80
2.1
2.6
10.4
10.3
g/l
0.06
36
158
20
54
3.85
6.71
4.8
3.4
—
—
—
0
0
53
249
2.31
6.70
2.0
2.3
0.2
0.2
g/l
0.47
45
230
170
1200
1.76
6.61
9.5
5.9
1.2
1.2
mmol/l
1.06
152
1069
127
824
1.82
6.56
2.9
2.4
68.0
57.5
u/l
1.25
114
757
99
596
1.90
6.47
2.1
1.7
501.8
8333762.1
pmol/l
0.50
76
480
76
419
2.02
6.41
3.7
3.2
0.8
0.8
mmol/l
1.19
70
388
195
1441
1.74
6.38
13.6
9.1
4.1
4.2
e9/l
0.21
179
1270
15
34
4.55
6.28
6.9
1.5
34.6
33.5
pg
0.35
15
34
105
650
1.85
6.27
3.8
2.8
4364.0
9098.8
umol/l
0.52
93
541
60
305
2.15
6.27
1.4
1.2
—
—
—
0
0
124
812
1.79
6.15
7.0
3.9
7.4
7.4
ph
0.37
27
148
10
16
6.39
5.97
2.9
1.6
—
—
—
0
0
37
156
2.52
5.92
1.4
1.2
—
—
—
0
0
56
284
2.14
5.88
1.8
1.6
—
—
—
0
0
81
474
1.90
5.71
1.4
1.2
4.0
1.3
u/ml
0.41
20
124
53
266
2.15
5.71
7.6
4.0
2.2
2.1
mmol/l
0.09
47
202
20
61
3.40
5.65
1.1
1.5
—
—
—
0
0
53
270
2.12
5.49
7.6
4.0
6.0
5.7
kpa
0.85
53
260
57
300
2.06
5.42
2.1
1.8
—
—
—
0
0
16
43
3.84
5.41
5.4
2.7
62.9
61.9
%
0.06
16
43
54
279
2.09
5.39
7.6
4.0
—
—
—
0
0
17
48
3.66
5.38
1.5
3.2
32.8
30.8
umol/l
0.18
12
40
160
1166
1.65
5.18
7.3
4.2
—
—
—
0
0
127
872
1.69
5.17
3.2
3.7
—
—
—
0
0
15
40
3.86
5.13
3.5
2.4
4.4
4.8
e9/l
0.21
15
40
10
19
5.37
5.06
1.9
1.1
—
—
—
0
0
200
1551
1.62
4.98
8.4
4.7
7.0
6.7
mmol/l
0.60
193
1443
15
41
3.77
4.96
4.4
2.9
57.5
60.8
%
0.35
15
41
44
217
2.16
4.95
6.2
4.6
1.1
0.9
%
0.24
18
76
66
379
1.90
4.89
2.7
2.1
—
—
—
0
0
17
52
3.37
4.79
1.6
1.3
—
—
—
0
0
46
235
2.09
4.73
4.5
3.0
4.3
4.3
kpa
0.01
46
223
85
537
1.75
4.62
7.7
5.5
—
—
—
0
0
39
191
2.16
4.47
5.4
4.7
0.5
0.4
%
—
10
53
155
1157
1.58
4.36
10.0
9.6
1.3
1.3
inr
0.37
46
318
45
237
2.02
4.27
2.1
1.8
424.7
375.2
nmol/l
0.68
40
211
38
191
2.10
4.09
6.6
4.9
0.0
0.2
%
0.57
15
58
93
625
1.65
3.98
8.4
6.6
—
—
—
0
0
39
202
2.04
3.88
4.3
6.3
—
—
—
0
0
38
198
2.02
3.73
6.7
4.9
0.1
0.2
%
0.60
17
66
40
213
1.98
3.70
1.7
1.4
—
—
—
0
0
45
250
1.91
3.68
1.8
1.5
—
—
—
0
0
46
262
1.86
3.49
2.2
2.1
196.9
159.6
ug/g
0.38
36
201
14
47
3.05
3.44
1.4
1.9
—
—
—
0
0
29
141
2.14
3.41
4.3
2.7
0.6
0.7
%
0.53
29
136
49
287
1.81
3.41
3.0
2.6
5.2
8.5
umol/l
1.88
43
253
143
1097
1.49
3.34
4.7
4.1
74.5
47.3
ng/l
0.36
107
821
16
60
2.74
3.26
1.1
1.2
—
—
—
0
0
86
598
1.57
3.15
3.3
2.6
9.0
5.0
e6/l
0.73
80
526
214
1791
1.46
3.13
5.9
4.6
—
—
—
0
0
123
928
1.48
3.08
4.2
3.1
2.3
2.3
mmol/l
1.72
105
795
90
636
1.55
3.06
5.6
3.7
86.6
87.1
%
0.07
83
619
10
29
3.51
3.06
1.3
1.2
—
—
—
0
0
5
5
10.10
2.98
2.2
1.2
—
—
—
0
0
11
35
3.20
2.94
1.3
1.2
—
—
—
0
0
113
848
1.48
2.88
4.3
3.3
54.9
146.8
e6/l
0.59
98
656
12
41
2.99
2.88
1.2
1.5
—
—
—
0
0
12
41
2.99
2.88
1.2
1.5
—
—
—
0
0
12
42
2.92
2.77
1.2
1.5
—
—
—
0
0
14
54
2.65
2.73
2.6
2.6
—
—
—
0
0
47
291
1.70
2.72
2.0
1.4
—
—
—
0
0
8
19
4.27
2.69
2.4
1.7
10.6
10.3
%
—
8
19
99
733
1.48
2.68
4.1
3.1
—
—
—
0
0
12
43
2.85
2.66
1.2
1.5
—
—
—
0
0
156
1259
1.41
2.64
5.0
4.2
0.0
0.0
estimate
0.00
28
241
230
1987
1.41
2.60
12.1
7.2
82.9
79.2
u/l
0.62
214
1846
102
765
1.46
2.57
4.2
3.2
0.2
0.5
e6/l
2.72
87
579
5
7
7.21
2.55
4.0
1.7
—
—
—
0
0
157
1278
1.39
2.50
5.2
4.3
0.0
0.0
estimate
0.00
27
230
123
960
1.42
2.50
5.0
3.9
112.1
100.5
e6/l
0.11
102
706
9
26
3.52
2.49
1.1
2.7
—
—
—
0
0
26
138
1.95
2.47
1.4
1.3
—
—
—
0
0
216
1857
1.39
2.45
6.2
4.2
22.2
13.4
mm/h
8.42
204
1677
18
83
2.23
2.44
7.3
10.6
1.1
1.2
mmol/l
0.39
18
75
79
570
1.49
2.42
2.6
3.1
511.7
557.1
mosm/kgh2o
1.08
67
482
136
1087
1.39
2.39
15.0
10.1
0.0
0.0
e9/l
0.44
111
892
45
286
1.65
2.38
1.6
1.3
502.2
515.3
titre
—
9
68
80
583
1.47
2.33
4.7
4.1
—
—
—
0
0
102
779
1.42
2.32
3.6
3.0
6.7
7.2
mmol/l
0.63
92
650
10
36
2.82
2.21
1.5
1.8
86.7
90.2
%
—
10
36
11
42
2.66
2.20
2.3
2.7
—
—
—
0
0
55
376
1.54
2.16
1.2
1.2
66.8
38.4
iu/ml
0.46
22
130
77
565
1.46
2.16
2.2
1.8
1.9
1.4
mg/l
0.43
65
435
7
19
3.73
2.16
2.4
1.2
—
—
—
0
0
11
43
2.60
2.11
1.2
1.5
—
—
—
0
0
7
20
3.54
2.06
1.4
1.8
—
—
—
0
0
103
804
1.39
2.04
4.4
3.9
18.5
9.4
mg/mmol
1.06
69
495
14
63
2.27
2.03
7.4
12.2
11.0
11.4
mmol/l
0.18
14
58
14
63
2.27
2.03
7.4
12.2
104.9
104.5
mmol/l
0.06
14
58
9
32
2.85
2.01
1.2
1.4
—
—
—
0
0
73
539
1.44
1.98
5.4
3.7
124.9
157.1
ng/l
0.12
61
450
152
1267
1.33
1.97
6.9
5.8
0.0
0.0
estimate
0.00
26
234
97
757
1.38
1.92
3.6
3.1
89.1
313.2
mg/l
0.88
67
481
11
46
2.43
1.86
2.6
2.3
—
—
—
0
0
5
12
4.20
1.82
2.4
1.6
129.8
136.5
nmol/l
—
5
12
8
29
2.79
1.80
1.6
1.7
—
—
—
0
0
8
29
2.79
1.80
1.6
1.7
—
—
—
0
0
8
29
2.79
1.80
1.6
1.7
—
—
—
0
0
8
29
2.79
1.80
1.6
1.7
—
—
—
0
0
8
29
2.79
1.80
1.0
1.0
—
—
—
0
0
200
1752
1.30
1.76
6.6
4.9
4924.0
2112.2
e6/l
—
7
32
8
30
2.70
1.73
6.6
3.6
—
—
—
0
0
6
145
0.40
1.68
2.8
1.3
—
—
—
0
0
8
31
2.61
1.66
1.6
2.1
—
—
—
0
0
5
14
3.60
1.62
1.4
1.1
—
—
—
0
0
10
43
2.36
1.61
4.6
2.5
—
—
—
0
0
14
70
2.04
1.60
1.6
1.2
—
—
—
0
0
11
50
2.23
1.58
4.9
2.1
—
—
—
0
0
50
360
1.45
1.56
1.2
1.3
1.2
14.7
u/ml
—
10
138
23
138
1.71
1.55
1.4
1.3
—
—
—
0
0
8
33
2.45
1.54
1.0
1.1
—
—
—
0
0
19
108
1.80
1.53
1.7
2.2
493.2
323.9
ug/l
0.24
19
100
5
15
3.36
1.52
2.8
2.3
—
—
—
0
0
53
388
1.42
1.52
23.8
28.3
1.3
1.3
inr
—
7
48
6
21
2.88
1.51
3.8
2.9
—
—
—
0
0
16
87
1.87
1.47
1.5
1.2
—
—
—
0
0
10
45
2.25
1.47
1.0
1.2
217.2
26.7
u/l
—
10
39
75
589
1.34
1.42
5.7
4.5
1.0
1.0
kg/l
1.03
14
91
5
17
2.96
1.36
1.4
1.2
—
—
—
0
0
204
1829
1.25
1.35
4.8
3.8
14.9
15.0
pmol/l
0.13
186
1610
5
18
2.80
1.28
4.4
1.3
573.4
478.0
e6/l
—
5
13
36
254
1.46
1.27
1.3
1.3
—
—
—
0
0
19
116
1.67
1.23
1.7
1.5
—
—
—
0
0
5
19
2.65
1.22
1.0
1.0
—
—
—
0
0
62
777
0.76
1.21
3.0
3.1
—
—
—
0
0
34
240
1.46
1.20
5.6
4.0
—
—
—
0
0
6
26
2.33
1.19
1.3
1.1
—
—
—
0
0
6
26
2.33
1.19
1.3
1.1
—
—
—
0
0
16
95
1.71
1.15
2.1
2.9
0.3
0.2
g/l
—
8
33
23
151
1.56
1.14
3.3
3.0
3.2
4.0
e9/l
0.83
15
117
86
713
1.27
1.10
5.0
4.3
0.0
0.0
estimate
0.00
25
231
85
704
1.27
1.09
4.7
3.9
—
—
—
0
0
5
21
2.40
1.09
1.2
1.8
—
—
—
0
0
15
90
1.69
1.05
3.9
1.9
—
—
—
0
0
109
935
1.23
1.03
2.1
2.3
—
—
—
0
0
5
23
2.19
0.98
1.2
4.3
—
—
—
0
0
10
54
1.87
0.97
1.1
1.4
—
2.6
—
0
12
6
29
2.08
0.89
1.2
1.4
—
—
—
0
0
8
43
1.88
0.87
1.4
1.2
—
—
—
0
0
6
30
2.01
0.87
1.7
1.2
—
—
—
0
0
21
145
1.47
0.86
4.7
4.6
—
—
—
0
0
8
44
1.83
0.86
2.8
1.3
—
—
—
0
0
9
150
0.59
0.80
1.0
1.4
—
—
—
0
0
44
545
0.78
0.80
3.1
3.2
0.7
0.8
ug/l
0.23
28
361
17
115
1.50
0.78
3.3
4.2
—
—
—
0
0
29
218
1.36
0.77
4.8
3.8
—
—
—
0
0
230
2434
0.85
0.77
5.1
5.2
2.5
2.6
mmol/l
1.72
211
2200
18
124
1.47
0.76
1.2
1.2
—
—
—
0
0
261
2733
0.84
0.75
45.5
23.1
3.9
4.4
e12/l
30.24
255
2642
66
557
1.22
0.74
3.0
3.1
2.4
2.5
mmol/l
0.68
56
483
226
2391
0.86
0.73
5.3
4.8
6.0
6.0
mmol/l
0.13
206
2134
5
25
2.01
0.73
1.2
1.2
—
—
—
0
0
7
39
1.81
0.73
1.3
1.4
—
—
—
0
0
20
143
1.42
0.71
3.7
2.5
—
—
—
0
0
7
41
1.72
0.70
1.3
1.4
7.8
8.7
u/l
—
7
34
10
61
1.65
0.69
5.8
3.3
—
—
—
0
0
25
188
1.35
0.68
2.1
2.3
12.0
13.0
nmol/l
0.17
20
170
225
2365
0.87
0.61
4.5
4.6
4.4
4.5
mmol/l
1.08
206
2155
17
122
1.41
0.61
1.2
1.3
—
—
—
0
0
30
237
1.29
0.60
3.1
3.5
—
—
—
0
0
215
2264
0.88
0.59
4.1
4.1
1.3
1.3
mmol/l
0.56
192
2034
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
26
204
1.29
0.55
1.2
1.4
—
—
—
0
0
6
38
1.59
0.54
1.5
1.5
7.4
29.7
iu/l
—
6
33
84
937
0.86
0.54
5.5
5.2
2.4
3.6
ug/l
0.75
73
818
225
2347
0.89
0.48
4.5
4.6
1.5
1.5
mmol/l
0.10
205
2118
22
173
1.29
0.47
5.2
3.7
—
—
—
0
0
7
49
1.43
0.46
2.0
1.4
0.8
0.8
nmol/l
—
7
40
11
77
1.44
0.45
19.6
9.7
—
—
—
0
0
7
51
1.38
0.44
2.6
2.6
—
—
—
0
0
8
56
1.44
0.43
1.1
1.4
—
—
—
0
0
5
36
1.39
0.38
2.0
1.6
—
—
—
0
0
257
2491
1.10
0.34
30.7
16.2
29.4
24.9
mg/l
1.22
226
1996
6
45
1.34
0.34
1.3
1.5
35.9
31.8
g/l
—
6
40
32
275
1.18
0.33
2.5
2.6
4.2
5.3
ug/l
0.39
24
237
173
1802
0.92
0.31
4.6
4.1
—
—
—
0
0
7
54
1.30
0.30
3.1
1.3
92.9
212.9
e6/l
—
7
45
7
54
1.30
0.30
3.1
1.2
1.6
7.9
e6/l
—
7
43
60
652
0.90
0.27
1.9
1.6
1.3
1.3
mmol/l
0.21
53
533
223
2293
0.93
0.27
7.0
6.1
39.5
40.7
mmol/mol
0.88
207
2098
255
2609
0.92
0.27
17.1
10.5
22.9
24.8
u/l
1.00
247
2498
26
298
0.86
0.26
1.1
1.3
—
—
—
0
0
231
2248
1.07
0.23
5.7
4.6
2.0
2.0
mu/l
0.20
206
1987
85
800
1.08
0.22
4.3
4.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
9
111
0.81
0.20
1.6
2.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
10
81
1.24
0.18
3.6
3.4
—
—
—
0
0
7
58
1.21
0.18
1.4
1.1
—
—
—
0
0
16
177
0.90
0.11
1.5
1.4
—
—
—
0
0
59
610
0.96
0.08
1.6
1.3
—
—
—
0
0
8
78
1.02
0.07
2.1
1.8
—
—
—
0
0
8
78
1.02
0.07
1.7
1.6
—
—
—
0
0
20
212
0.94
0.05
1.7
1.6
—
—
—
0
0
218
2190
0.99
0.03
34.2
17.2
35.7
39.2
%
4.79
138
1441
257
2577
0.99
0.02
28.2
15.1
—
—
—
0
0
10
97
1.03
0.00
3.8
5.5
—
—
—
0
0
21
214
0.98
0.00
1.5
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
6
64
0.94
0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
10.6
—
0.6
—
0
9
6
64
0.94
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.8
—
—
—
0
0
8
79
1.01
0.00
1.1
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
3.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
19.2
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint D3_NUTRIANAEMIAOTHER and mortality.

Females

Parameter HR [95% CI] p-value
D3_NUTRIANAEMIAOTHER 2.436 [2.09, 2.84] < 0.001
Birth year 0.992 [0.98, 1.0] 0.076

During the follow-up period (1.1.1998 — 31.12.2019), 1095 out of 1787 females with D3_NUTRIANAEMIAOTHER died.

Males

Parameter HR [95% CI] p-value
D3_NUTRIANAEMIAOTHER 2.566 [2.12, 3.1] < 0.001
Birth year 0.987 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 1049 out of 1608 males with D3_NUTRIANAEMIAOTHER died.

Mortality risk

Mortality risk for people of age

years, who have D3_NUTRIANAEMIAOTHER.

N-year risk Females Males
1 0.188% 0.502%
5 1.359% 3.048%
10 3.342% 7.784%
15 6.272% 14.518%
20 10.55% 24.067%

Relationships between endpoints

Index endpoint: D3_NUTRIANAEMIAOTHER – Other nutritional anaemias

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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