Other nutritional anaemias

D3_NUTRIANAEMIAOTHER

anemia (phenotype): ['A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin.']

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D53
  • Hospital discharge: ICD-9 281[8-9]
  • Hospital discharge: ICD-8 281[3-9]
  • Cause of death: ICD-10 D53
  • Cause of death: ICD-9 281[8-9]
  • Cause of death: ICD-8 281[3-9]

2 out of 7 registries used, show all original rules.

384

4. Check minimum number of events

None

384

5. Include endpoints

None

384

6. Filter based on genotype QC (FinnGen only)

370

Control definitions (FinnGen only)

Control exclude
D3_NUTRIANAEMIA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D50-D53
Name in latin
Aliae anaemiae nutritionales

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6137 3333 2692
Only index persons 3304 1855 1449
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.08
Only index persons 0.06 0.07 0.06
Median age at first event (years)
Whole population 68.88 69.46 68.16
Only index persons 62.81 61.05 65.05

-FinnGen-

Key figures

All Female Male
Number of individuals 370 180 190
Unadjusted period prevalence (%) 0.08 0.06 0.09
Median age at first event (years) 63.63 58.76 68.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
384
Matched controls
3835
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
6721.4
280.0
235
*
D64.9
ICD-10 Finland
Anaemia, unspecified
10.0
102.0
152
236
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
35.0
95.3
62
21
B03BA03
ATC
hydroxocobalamin; parenteral
13.3
90.8
97
95
D53.9
ICD-10 Finland
Nutritional anaemia, unspecified
+∞
69.9
65
*
107
Kela drug reimbursment
Pernicious anaemia
+∞
60.0
56
*
B81
ICPC
Anaemia vit B12/folate deficiency
14.1
54.9
53
43
K29.4
ICD-10 Finland
Chronic atrophic gastritis
17.5
48.4
41
26
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.9
36.9
171
657
28199
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Other and unspecified deficiency anaemia
+∞
34.9
33
*
XW000
NOMESCO Finland
Bone marrow biopsy
7.8
33.0
49
71
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
326.4
30.2
30
*
2819X
ICD-9 Finland
Other deficiency anaemias, Unspecified deficiency anaemia
+∞
18.9
18
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.0
16.6
52
146
WW500
NOMESCO Finland
Blood transfusion
4.9
16.2
37
81
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
24.5
15.3
21
9
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
37.6
14.6
18
5
C03CA01
ATC
furosemide; systemic
2.3
14.1
190
1150
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.2
13.8
38
97
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
9.5
12.4
25
28
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
23.7
11.7
16
7
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
11.5
68
280
B82
ICPC
Anaemia other/unspecified
5.8
11.3
21
38
D53.8
ICD-10 Finland
Other specified nutritional anaemias
+∞
10.5
10
*
M04AA01
ATC
allopurinol; systemic
2.4
10.4
79
367
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
10.2
63
264
D64.8
ICD-10 Finland
Other specified anaemias
11.0
9.9
18
17
R53
ICD-10 Finland
Malaise and fatigue
2.1
9.6
113
628
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
9.5
143
871
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.5
9.2
33
101
SPAT1254
SPAT
Administration of medicine
2.3
9.2
76
366
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.7
9.1
29
82
UJF30
NOMESCO Finland
Ileoscopy through colon
2.9
8.9
43
158
UJF32
NOMESCO Finland
Coloscopy
2.1
8.6
107
606
28198
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Alia definita
+∞
8.4
8
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
8.2
75
376
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
8.1
67
321
L04AA01
ATC
[U] ciclosporin
13.4
7.9
13
10
SPAT1255
SPAT
Intravenous administration of medicine
3.1
7.8
33
112
B80
ICPC
Iron deficiency anaemia
7.7
7.7
17
23
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
7.6
146
951
L04AX01
ATC
azathioprine; systemic
4.2
7.4
20
50
E87.6
ICD-10 Finland
Hypokalaemia
3.6
7.4
24
69
N18.8
ICD-10 Finland
Other chronic renal failure
5.8
7.2
19
34
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.2
7.0
28
92
A46
ICD-10 Finland
Erysipelas
2.1
6.9
69
357
D52.9
ICD-10 Finland
Folate deficiency anaemia, unspecified
40.7
6.8
8
*
N19
ICD-10 Finland
Unspecified kidney failure
3.3
6.7
25
79
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.3
6.4
24
76
B03XA02
ATC
darbepoetin alfa; parenteral
5.7
6.4
17
31
L01BA01
ATC
methotrexate; systemic
4.0
6.3
18
47
ZXD05
NOMESCO Finland
Urgent procedure
1.8
6.3
118
755
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
6.3
82
467
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
6.3
6
*
28110
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Other vitamin B12 deficiency
+∞
6.3
6
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
6.1
130
862
127
Kela drug reimbursment
Transplant complication
12.8
6.1
10
8
L04AD01
ATC
ciclosporin; systemic
8.8
6.1
12
14
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.7
6.0
16
29

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
81
119
8.35
54.76
2.9
2.1
1.37
1.53
g/l
0.69
65
105
129
319
5.58
51.73
5.7
2.5
2.13
1.73
%
1.42
113
293
107
233
5.97
49.20
5.7
2.6
69.21
67.26
e9/l
0.13
87
187
121
377
4.22
34.97
3.4
2.2
2.19
2.25
g/l
0.53
112
346
124
412
3.96
32.49
3.5
2.2
13.98
12.83
umol/l
0.63
113
380
113
354
4.10
32.14
3.6
2.3
27.27
22.51
%
1.19
95
297
164
678
3.47
30.55
3.0
1.9
3.23
3.10
mg/l
0.21
136
567
138
566
3.24
25.25
2.2
1.8
1343.05
1196.55
nmol/l
0.93
101
416
192
1026
2.74
20.78
4.6
2.4
234.38
131.76
ug/l
2.84
172
920
27
39
7.36
18.02
3.8
1.8
—
—
—
0
0
88
342
3.04
16.93
8.6
5.5
1.06
1.04
mmol/l
0.19
83
309
29
49
6.31
16.73
1.4
1.4
—
—
—
0
0
135
671
2.56
16.07
2.2
1.6
19.36
21.06
nmol/l
0.60
121
559
33
66
5.37
16.00
1.5
4.1
—
—
—
0
0
40
96
4.53
15.69
1.9
3.4
40.67
136.68
mg/l
0.77
29
74
40
96
4.53
15.69
2.0
3.4
33.19
28.58
mg/l
0.36
29
74
191
1138
2.35
14.95
2.9
2.0
89.31
94.53
pmol/l
0.82
119
563
152
825
2.39
14.69
5.9
4.2
—
—
—
0
0
57
197
3.22
13.23
1.9
2.3
—
—
—
0
0
190
1172
2.23
13.20
9.5
6.3
—
—
—
0
0
192
1199
2.20
12.83
10.0
5.9
8.59
8.73
%
0.20
177
1118
199
1266
2.18
12.62
8.9
5.5
0.59
0.60
e9/l
0.04
180
1115
194
1223
2.18
12.58
9.6
5.8
25.99
26.82
%
0.42
179
1146
190
1189
2.18
12.55
9.5
5.6
2.85
2.77
%
0.15
176
1106
199
1269
2.18
12.51
8.9
5.5
0.03
0.04
e9/l
2.53
180
1118
63
239
2.95
12.44
1.9
2.7
65.99
65.75
g/l
0.09
58
211
203
1313
2.15
12.21
9.2
5.7
0.20
0.19
e9/l
0.25
184
1170
201
1299
2.14
12.07
9.0
5.6
1.77
1.95
e9/l
0.72
181
1176
184
1161
2.12
11.64
9.3
5.6
0.61
0.65
%
0.39
170
1081
187
1205
2.07
11.00
9.2
5.6
58.00
58.24
%
0.09
172
1133
21
24
9.18
10.40
1.0
1.3
—
—
—
0
0
39
132
3.17
9.32
3.1
3.7
—
—
—
0
0
85
433
2.23
8.95
1.7
1.6
2.89
2.36
g/l
1.11
47
256
179
1199
1.92
8.86
7.5
4.3
33.69
35.04
g/l
2.04
166
1104
203
1422
1.90
8.72
8.6
5.8
12.34
11.91
umol/l
0.15
184
1343
51
209
2.66
8.63
6.0
3.7
105.79
80.05
ng/l
0.79
43
185
67
314
2.37
8.55
1.4
1.2
—
—
—
0
0
196
1377
1.86
8.16
11.1
6.6
1.21
1.21
mmol/l
0.68
165
1169
134
836
1.92
8.05
4.0
2.5
—
—
—
0
0
18
25
7.49
8.05
1.4
1.1
—
—
—
0
0
68
337
2.23
7.59
6.2
7.5
1.22
1.52
mmol/l
0.17
52
264
44
180
2.63
7.46
2.2
2.6
10.64
10.34
g/l
0.14
38
162
19
33
5.99
7.31
1.7
1.4
—
—
—
0
0
206
1507
1.79
7.19
13.2
8.7
4.07
4.19
e9/l
0.38
189
1326
178
1250
1.79
7.12
9.4
5.8
1.20
1.21
mmol/l
0.90
160
1119
51
233
2.37
6.86
9.8
7.7
—
—
—
0
0
109
669
1.88
6.70
3.9
2.8
4280.23
8771.78
umol/l
0.50
95
562
54
256
2.29
6.67
2.1
2.2
0.20
0.21
g/l
0.40
46
238
36
141
2.71
6.65
8.4
11.6
—
—
—
0
0
131
854
1.81
6.63
2.9
2.5
528.96
62.92
u/l
0.50
117
788
79
437
2.01
6.59
3.7
3.2
0.79
0.82
mmol/l
1.25
73
406
102
616
1.89
6.58
2.1
1.7
503.06
8114023.41
pmol/l
0.50
77
493
61
306
2.18
6.58
2.0
1.7
—
—
—
0
0
129
840
1.80
6.54
6.9
3.8
7.39
7.40
ph
0.35
28
151
21
60
3.64
6.52
1.0
1.5
—
—
—
0
0
59
298
2.15
6.25
1.8
1.6
—
—
—
0
0
20
58
3.58
6.08
4.8
3.1
—
—
—
0
0
39
167
2.48
6.03
1.3
1.2
—
—
—
0
0
55
282
2.11
5.59
7.4
3.8
2.13
2.09
mmol/l
0.02
48
218
16
33
5.01
5.48
6.6
1.5
34.50
33.58
pg
0.30
16
33
133
914
1.69
5.40
3.5
3.7
—
—
—
0
0
55
286
2.07
5.39
7.4
3.8
5.95
5.71
kpa
0.81
55
276
18
53
3.51
5.36
1.6
1.4
—
—
—
0
0
69
391
1.93
5.32
2.6
2.1
—
—
—
0
0
208
1610
1.63
5.26
8.3
4.7
6.92
6.74
mmol/l
0.45
201
1503
83
502
1.83
5.23
1.4
1.3
4.04
1.52
u/ml
0.35
19
139
166
1216
1.64
5.23
4.4
2.6
—
—
—
0
0
45
220
2.18
5.16
6.1
4.6
1.00
0.90
%
0.14
24
90
48
246
2.08
4.89
2.1
2.0
437.16
378.70
nmol/l
0.90
43
219
16
47
3.50
4.79
5.4
2.6
62.94
62.02
%
0.05
16
47
40
193
2.19
4.74
5.3
4.7
0.37
0.56
%
0.50
20
71
21
75
2.90
4.62
2.5
2.8
1.89
1.62
mg/l
0.54
16
64
48
252
2.03
4.58
6.7
6.0
1.47
1.45
mmol/l
0.04
48
242
15
44
3.50
4.50
3.5
2.7
4.44
4.72
e9/l
0.14
15
44
18
60
3.09
4.45
1.1
1.2
—
—
—
0
0
47
248
2.02
4.43
4.4
2.9
4.30
4.37
kpa
0.11
47
236
31
139
2.34
4.37
7.1
8.6
24.22
24.70
mmol/l
0.33
31
132
15
45
3.42
4.36
4.4
3.1
57.47
60.13
%
0.27
15
45
181
1397
1.56
4.34
16.9
17.0
1.33
1.30
inr
0.13
53
384
39
194
2.12
4.29
6.5
4.9
0.05
0.03
%
0.15
19
65
53
300
1.89
4.09
3.1
2.6
5.09
8.61
umol/l
2.29
47
267
39
201
2.04
3.93
6.6
4.8
0.06
0.14
%
0.58
18
71
130
951
1.55
3.87
4.1
3.1
2.33
2.35
mmol/l
1.13
111
824
47
263
1.89
3.75
1.8
1.5
—
—
—
0
0
95
651
1.61
3.72
8.2
6.4
—
—
—
0
0
10
21
4.85
3.57
1.9
1.1
—
—
—
0
0
41
223
1.94
3.56
1.7
1.4
—
—
—
0
0
142
1080
1.50
3.45
3.1
2.2
78.06
77.81
nmol/l
0.03
122
941
91
629
1.58
3.42
3.4
2.6
8.76
4.87
e6/l
0.74
84
564
39
213
1.92
3.36
4.3
6.2
—
—
—
0
0
48
281
1.81
3.34
2.2
2.1
219.14
156.82
ug/g
0.68
37
217
147
1135
1.48
3.28
4.7
4.1
74.05
46.82
ng/l
0.37
109
851
223
1867
1.46
3.26
6.0
4.5
—
—
—
0
0
94
663
1.55
3.22
5.7
3.7
87.68
86.80
%
0.11
87
646
14
49
2.92
3.21
1.4
1.8
—
—
—
0
0
12
35
3.50
3.13
1.3
1.2
—
—
—
0
0
118
883
1.48
3.05
4.4
3.3
53.50
149.78
e6/l
0.66
102
681
49
297
1.74
3.04
1.6
1.3
447.27
514.78
titre
0.11
11
69
15
57
2.69
2.99
2.5
2.4
—
—
—
0
0
5
5
10.09
2.98
2.2
1.2
—
—
—
0
0
115
863
1.47
2.91
2.2
2.1
213.07
207.67
u/l
0.03
109
810
143
1121
1.44
2.87
15.0
9.9
0.00
0.00
e9/l
0.44
116
919
26
130
2.07
2.87
2.8
1.8
1.19
1.25
ug/l
0.03
21
113
239
2055
1.43
2.85
12.1
7.1
83.49
79.34
u/l
0.70
223
1915
10
29
3.51
2.70
1.3
1.2
—
—
—
0
0
8
19
4.27
2.69
2.4
1.7
10.59
10.34
%
—
8
19
9
24
3.81
2.68
3.3
1.4
0.78
0.92
e9/l
—
9
19
27
141
1.98
2.67
1.4
1.4
—
—
—
0
0
226
1937
1.40
2.66
6.4
4.1
22.08
13.29
mm/h
8.69
213
1754
48
301
1.68
2.65
2.0
1.4
—
—
—
0
0
106
797
1.45
2.63
4.3
3.2
0.19
0.46
e6/l
2.71
90
606
9
25
3.66
2.58
1.1
2.7
—
—
—
0
0
134
1055
1.41
2.58
4.4
3.9
5.40
5.73
ph
—
5
69
5
7
7.21
2.55
4.0
1.7
—
—
—
0
0
128
1003
1.41
2.52
5.0
3.9
110.40
101.78
e6/l
0.08
106
736
102
767
1.45
2.52
4.3
3.1
—
—
—
0
0
83
605
1.47
2.40
2.8
3.2
506.69
545.15
mosm/kgh2o
0.91
70
513
106
817
1.41
2.27
3.6
3.0
6.72
7.22
mmol/l
0.63
95
683
81
598
1.45
2.19
4.7
4.1
—
—
—
0
0
107
832
1.39
2.17
4.2
3.7
18.28
9.28
mg/mmol
1.07
70
512
9
30
3.04
2.15
1.0
1.0
—
—
—
0
0
57
393
1.53
2.15
1.2
1.2
66.81
37.82
iu/ml
0.47
22
132
76
557
1.45
2.13
5.4
3.8
123.25
164.20
ng/l
0.17
63
467
12
49
2.49
2.12
1.2
1.6
—
—
—
0
0
12
49
2.49
2.12
1.2
1.6
—
—
—
0
0
158
1314
1.34
2.08
5.1
4.2
0.00
0.00
estimate
-0.00
31
273
6
15
4.04
2.04
1.3
1.1
—
—
—
0
0
12
50
2.44
2.04
1.2
1.6
—
—
—
0
0
12
50
2.44
2.04
2.2
2.9
—
—
—
0
0
210
1825
1.33
2.03
6.7
4.9
4924.00
2809.74
e6/l
—
7
35
18
90
2.05
2.03
7.3
10.2
1.12
1.20
mmol/l
0.31
18
82
11
44
2.54
2.02
4.3
2.5
—
—
—
0
0
10
38
2.67
2.01
1.5
1.8
86.73
90.03
%
—
10
38
39
250
1.62
2.01
5.5
3.9
—
—
—
0
0
159
1330
1.33
2.00
5.2
4.2
0.00
0.00
estimate
-0.00
28
240
101
788
1.38
1.99
3.6
3.1
86.89
301.24
mg/l
0.88
69
503
38
243
1.62
1.98
3.3
2.5
86.64
32.59
u/l
0.69
33
196
7
21
3.37
1.97
4.1
2.9
—
—
—
0
0
7
21
3.37
1.97
2.4
1.2
—
—
—
0
0
12
51
2.39
1.96
1.2
1.5
—
—
—
0
0
11
45
2.48
1.94
2.6
2.2
—
—
—
0
0
6
16
3.79
1.94
2.7
2.3
—
—
—
0
0
7
22
3.22
1.88
1.4
1.7
—
—
—
0
0
7
22
3.22
1.88
4.0
1.9
33.19
34.85
%
—
7
22
11
46
2.43
1.86
1.5
1.2
—
—
—
0
0
13
59
2.24
1.85
4.6
2.4
—
—
—
0
0
117
946
1.34
1.83
3.7
3.1
2439.49
1801.19
ng/l
0.78
107
808
5
12
4.20
1.82
2.4
1.6
129.80
136.50
nmol/l
—
5
12
8
29
2.79
1.80
6.6
3.6
—
—
—
0
0
14
67
2.13
1.77
7.4
12.0
11.00
11.23
mmol/l
0.10
14
62
14
67
2.13
1.77
7.4
12.0
104.93
104.74
mmol/l
0.02
14
62
17
88
1.97
1.77
1.5
1.2
—
—
—
0
0
9
36
2.53
1.74
1.0
1.1
—
—
—
0
0
7
160
0.43
1.71
2.6
1.3
—
—
—
0
0
77
589
1.38
1.71
2.2
1.8
1.91
1.42
mg/l
0.47
64
452
52
374
1.45
1.62
1.2
1.3
1.28
14.33
u/ml
2.44
11
143
24
145
1.70
1.57
1.5
1.3
—
—
—
0
0
154
1319
1.28
1.54
6.8
5.8
0.00
0.00
estimate
-0.00
27
246
11
51
2.19
1.51
1.2
1.5
—
—
—
0
0
9
37
2.46
1.48
1.6
1.9
—
—
—
0
0
181
1586
1.26
1.48
5.1
3.0
80.77
50.60
u/l
2.56
166
1463
9
38
2.40
1.46
1.2
1.4
—
—
—
0
0
21
125
1.72
1.46
1.7
1.5
—
—
—
0
0
59
444
1.39
1.45
4.0
3.1
3.43
2.42
e6/l
0.40
35
253
213
1910
1.26
1.41
4.7
3.9
14.90
14.95
pmol/l
0.09
193
1684
25
158
1.62
1.41
3.3
2.9
3.23
5.98
e9/l
0.97
15
128
14
74
1.92
1.40
1.6
1.2
—
—
—
0
0
63
803
0.74
1.37
3.1
3.1
—
—
—
0
0
19
113
1.71
1.34
1.7
2.1
493.16
319.99
ug/l
0.25
19
105
17
98
1.77
1.32
2.1
2.9
0.29
0.27
g/l
—
8
35
5
18
2.80
1.28
4.4
1.3
573.40
478.00
e6/l
—
5
13
16
92
1.77
1.26
3.7
1.9
—
—
—
0
0
115
976
1.25
1.20
2.1
2.3
—
—
—
0
0
37
266
1.43
1.19
1.4
1.3
—
—
—
0
0
6
26
2.32
1.19
1.2
1.2
—
—
—
0
0
23
150
1.57
1.17
3.7
2.5
—
—
—
0
0
7
30
2.35
1.13
1.6
1.2
—
—
—
0
0
20
129
1.58
1.07
1.2
1.2
—
—
—
0
0
75
613
1.28
1.07
5.7
4.5
1.01
1.02
kg/l
0.98
14
92
5
22
2.29
1.03
1.2
1.4
—
—
—
0
0
5
22
2.29
1.03
1.0
1.0
—
—
—
0
0
40
301
1.37
1.02
2.8
4.2
16.56
27.08
ug/l
0.23
35
255
9
158
0.56
1.01
1.0
1.4
—
—
—
0
0
11
61
1.82
0.99
5.4
3.3
—
—
—
0
0
45
567
0.77
0.92
3.1
3.2
0.72
0.78
ug/l
0.20
28
368
6
29
2.08
0.89
1.3
1.1
—
—
—
0
0
6
29
2.08
0.89
1.3
1.1
—
—
—
0
0
87
745
1.21
0.83
5.0
4.3
0.00
0.00
estimate
-0.00
26
243
8
46
1.75
0.83
2.8
1.4
—
—
—
0
0
68
570
1.23
0.80
3.1
3.1
2.44
2.46
mmol/l
0.61
58
496
86
739
1.21
0.80
4.7
3.9
—
—
—
0
0
21
148
1.44
0.79
4.7
4.6
—
—
—
0
0
30
227
1.35
0.77
4.8
3.8
—
—
—
0
0
5
24
2.09
0.74
1.2
1.5
—
—
—
0
0
10
60
1.68
0.72
1.4
2.3
122.00
128.65
g/l
—
5
46
7
41
1.72
0.70
1.3
1.6
—
—
—
0
0
5
27
1.86
0.68
1.2
1.7
—
—
—
0
0
273
2844
0.86
0.67
45.0
22.9
3.86
4.42
e12/l
31.87
267
2752
273
2843
0.86
0.66
45.5
23.0
35.60
39.63
%
16.15
254
2620
31
243
1.30
0.64
3.0
3.5
—
—
—
0
0
241
2530
0.87
0.64
5.1
5.1
2.47
2.63
mmol/l
1.69
218
2291
26
199
1.33
0.64
2.1
2.3
11.48
12.82
nmol/l
0.26
21
180
93
824
1.17
0.62
4.2
4.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
0.09
—
0
14
87
969
0.87
0.54
5.6
5.2
2.33
3.51
ug/l
0.79
76
847
237
2477
0.88
0.54
5.3
4.7
5.97
6.03
mmol/l
0.30
215
2211
27
214
1.28
0.53
1.3
1.4
—
—
—
0
0
17
126
1.36
0.52
1.2
1.3
—
—
—
0
0
7
45
1.56
0.49
1.3
1.8
7.76
8.55
u/l
—
7
38
236
2458
0.89
0.48
4.5
4.6
4.39
4.52
mmol/l
0.99
212
2242
16
121
1.33
0.44
3.4
4.2
—
—
—
0
0
7
51
1.38
0.44
2.0
1.4
0.80
0.83
nmol/l
—
7
42
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
226
2348
0.91
0.41
4.1
4.1
1.34
1.27
mmol/l
0.59
199
2107
0
17
0.00
0.40
0.0
1.2
—
179.75
—
0
17
0
17
0.00
0.40
0.0
2.9
—
21.40
—
0
5
268
2592
1.11
0.39
30.5
16.0
29.28
24.83
mg/l
1.24
237
2080
5
36
1.39
0.38
2.0
1.6
—
—
—
0
0
22
180
1.23
0.36
5.2
3.6
—
—
—
0
0
11
81
1.37
0.36
19.6
9.3
—
—
—
0
0
6
42
1.43
0.35
1.5
2.0
7.35
27.53
iu/l
—
6
36
236
2438
0.91
0.35
4.6
4.5
1.45
1.46
mmol/l
0.14
212
2202
33
284
1.18
0.34
2.5
2.5
4.14
5.31
ug/l
0.43
25
244
6
46
1.31
0.33
1.3
1.5
35.92
31.85
g/l
—
6
41
243
2352
1.09
0.31
5.7
4.6
2.05
1.99
mu/l
0.25
217
2087
7
53
1.32
0.31
2.6
2.5
—
—
—
0
0
179
1863
0.92
0.30
4.5
4.1
—
—
—
0
0
7
57
1.23
0.29
3.1
1.2
1.57
7.43
e6/l
—
7
46
7
57
1.23
0.29
1.1
1.4
—
—
—
0
0
7
57
1.23
0.29
3.1
1.4
92.86
203.87
e6/l
—
7
48
62
675
0.90
0.29
1.9
1.6
1.35
1.30
mmol/l
0.21
55
554
10
77
1.30
0.26
1.7
1.6
—
—
—
0
0
266
2711
0.93
0.22
17.2
10.4
22.99
24.80
u/l
0.91
258
2598
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
10.7
—
0.57
—
0
11
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
28
311
0.89
0.19
1.1
1.3
—
—
—
0
0
7
58
1.21
0.18
1.4
1.1
—
—
—
0
0
10
119
0.83
0.16
1.7
2.7
—
—
—
0
0
16
182
0.87
0.15
1.4
1.4
—
—
—
0
0
234
2379
0.95
0.15
6.9
6.0
39.41
40.79
mmol/mol
1.19
214
2176
61
636
0.95
0.11
1.6
1.3
—
—
—
0
0
10
86
1.17
0.11
3.6
3.3
—
—
—
0
0
9
84
1.07
0.07
1.1
1.1
—
—
—
0
0
21
222
0.94
0.05
1.5
1.5
—
—
—
0
0
21
222
0.94
0.05
2.1
1.5
—
—
—
0
0
267
2681
0.98
0.03
28.0
15.0
—
—
—
0
0
10
98
1.02
0.00
3.8
5.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
-0.00
2.8
1.7
210.60
242.29
pmol/l
—
5
49
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
19.18
—
0
6
0
5
0.00
-0.00
0.0
5.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
8
84
0.95
-0.00
2.1
1.8
—
—
—
0
0
7
70
1.00
-0.00
1.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint D3_NUTRIANAEMIAOTHER and mortality.

Females

Parameter HR [95% CI] p-value
D3_NUTRIANAEMIAOTHER 2.436 [2.09, 2.84] < 0.001
Birth year 0.992 [0.98, 1.0] 0.076

During the follow-up period (1.1.1998 — 31.12.2019), 1095 out of 1787 females with D3_NUTRIANAEMIAOTHER died.

Males

Parameter HR [95% CI] p-value
D3_NUTRIANAEMIAOTHER 2.566 [2.12, 3.1] < 0.001
Birth year 0.987 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 1049 out of 1608 males with D3_NUTRIANAEMIAOTHER died.

Mortality risk

Mortality risk for people of age

years, who have D3_NUTRIANAEMIAOTHER.

N-year risk Females Males
1 0.188% 0.502%
5 1.359% 3.048%
10 3.342% 7.784%
15 6.272% 14.518%
20 10.55% 24.067%

Relationships between endpoints

Index endpoint: D3_NUTRIANAEMIAOTHER – Other nutritional anaemias

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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