anemia (phenotype): ['A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
372 |
4. Check minimum number of eventsNone |
372 |
5. Include endpointsNone |
372 |
6. Filter based on genotype QC (FinnGen only) |
372 |
Control definitions (FinnGen only)
- Control exclude
- D3_NUTRIANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D50-D53
- Name in latin
- Aliae anaemiae nutritionales
Similar endpoints
↥List of similar endpoints to Other nutritional anaemias based on the number of shared cases.
Similar with more cases:
- Nutritional anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 6137 | 3333 | 2692 |
Only index persons | 3304 | 1855 | 1449 |
Unadjusted period prevalence (%) | |||
Whole population | 0.09 | 0.10 | 0.08 |
Only index persons | 0.06 | 0.07 | 0.06 |
Median age at first event (years) | |||
Whole population | 68.88 | 69.46 | 68.16 |
Only index persons | 62.81 | 61.05 | 65.05 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 372 | 175 | 197 |
Unadjusted period prevalence (%) | 0.07 | 0.06 | 0.09 |
Median age at first event (years) | 63.46 | 58.15 | 68.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 343
- Matched controls
- 3440
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint D3_NUTRIANAEMIAOTHER and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
D3_NUTRIANAEMIAOTHER | 2.436 [2.09, 2.84] | < 0.001 |
Birth year | 0.992 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 1095 out of 1787 females with D3_NUTRIANAEMIAOTHER died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
D3_NUTRIANAEMIAOTHER | 2.566 [2.12, 3.1] | < 0.001 |
Birth year | 0.987 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 1049 out of 1608 males with D3_NUTRIANAEMIAOTHER died.
Mortality risk
Mortality risk for people of age
years, who have D3_NUTRIANAEMIAOTHER.N-year risk | Females | Males |
---|---|---|
1 | 0.188% | 0.502% |
5 | 1.359% | 3.048% |
10 | 3.342% | 7.784% |
15 | 6.272% | 14.518% |
20 | 10.55% | 24.067% |
Relationships between endpoints
↥Index endpoint: D3_NUTRIANAEMIAOTHER – Other nutritional anaemias
GWS hits: -