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Other nonthrombocytopenic purpura

DOID EFO Endpoint Browser PheWeb

D3_OTHNONTHROMBOCYTOPENPURPURA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D69.2
  • Hospital discharge: ICD-9 — 2872
  • Cause of death: ICD-10 — D69.2
  • Cause of death: ICD-9 — 2872

2 out of 7 registries used, show all original rules.

342

4. Check minimum number of events

None

342

5. Include endpoints

None

342

6. Filter based on genotype QC (FinnGen only)

332

Control definitions (FinnGen only)

Control exclude
D3_COAGDEF_PURPUR_HAEMORRHAGIC

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D69
Name in latin
Purpura non thrombocytopenica

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2281 1241 1022
Only index persons 1995 1125 870
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.03
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 61.62 63.49 59.23
Only index persons 59.44 61.58 56.67

-FinnGen-

Key figures

All Female Male
Number of individuals 332 196 136
Unadjusted period prevalence (%) 0.07 0.07 0.06
Median age at first event (years) 60.63 58.93 63.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
342
Matched controls
3420
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
12609.1
307.7
325
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.7
61.5
106
188
D69.0
ICD-10 Finland
Allergic purpura
526.0
47.5
46
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.4
36.0
124
391
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
163.9
29.1
30
*
H02AB06
ATC
prednisolone; systemic
3.2
23.7
215
1188
D07AC01
ATC
betamethasone; topical
3.0
22.4
170
843
L04AX01
ATC
azathioprine; systemic
7.2
21.2
33
50
E0000UV, ,
ATC
2.9
20.3
185
998
2872B
ICD-9 Finland
Purpura and other haemorrhagic conditions, Other nonthrombocytopenic purpuras
+∞
18.9
18
*
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
17.9
17
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
31.8
16.3
21
7
D07AB08
ATC
desonide; topical
3.5
16.0
63
208
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.3
15.6
33
68
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.9
14.5
27
49
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.2
14.2
65
235
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
13.5
187
1159
WW200
NOMESCO Finland
Immunization
6.6
13.4
22
35
A46
ICD-10 Finland
Erysipelas
2.8
13.1
75
307
L81.7
ICD-10 Finland
Pigmented purpuric dermatosis
29.7
13.1
17
6
R60.0
ICD-10 Finland
Localized oedema
3.0
12.6
64
245
R50.9
ICD-10 Finland
Fever, unspecified
2.8
12.5
72
295
D07AB02
ATC
hydrocortisone butyrate; topical
2.4
12.1
121
645
D07AD01
ATC
clobetasol; topical
2.7
12.0
75
321
C03CA01
ATC
furosemide; systemic
2.3
11.5
130
728
R60.9
ICD-10 Finland
Oedema, unspecified
4.0
11.1
33
89
D07AC13
ATC
mometasone; topical
2.3
10.8
116
632
B01AA03
ATC
warfarin; systemic
2.4
10.2
81
386
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
10.1
140
842
S29
ICPC
Skin symptom/complaint other
2.4
9.7
81
394
R23.3
ICD-10 Finland
Spontaneous ecchymoses
7.5
9.7
22
31
L17
ICPC
Foot/toe symptom/complaint
2.1
9.7
119
681
XW000
NOMESCO Finland
Bone marrow biopsy
4.2
9.5
26
66
A02BC02
ATC
pantoprazole; systemic
2.2
9.4
245
1842
S16
ICPC
Bruise/contusion
5.0
9.2
20
42
L95.8
ICD-10 Finland
Other vasculitis limited to skin
37.8
9.1
11
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.6
8.9
55
232
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
8.7
30
90
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
8.7
48
191
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
92.2
8.5
9
*
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
8.4
8
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.6
8.3
51
214
L04AX03
ATC
methotrexate; systemic
2.8
8.3
44
171
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
17.7
8.1
12
7
XQ848
NOMESCO Finland
Dermatological photography
4.5
8.0
20
47
ZX120
NOMESCO Finland
Intravenous
2.7
8.0
44
175
S97
ICPC
Chronic ulcer skin
3.1
7.8
34
118
E000001, ,
ATC
2.2
7.7
76
394
D07BC01
ATC
betamethasone and antiseptics; topical
2.6
7.7
49
209
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
7.7
75
387
P01BA02
ATC
hydroxychloroquine; oral
2.8
7.6
39
149
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
7.3
47
202
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
7.3
47
202
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.6
7.1
24
71
R06AE07
ATC
cetirizine; oral
1.8
6.9
154
1056
J01FF01
ATC
clindamycin; systemic
2.0
6.9
100
597
R06.0
ICD-10 Finland
Dyspnoea
1.9
6.8
105
639
M13.9
ICD-10 Finland
Arthritis, unspecified
2.8
6.8
34
128
N02AX02
ATC
tramadol; systemic, rectal
1.8
6.7
154
1061
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.0
6.7
85
484
L40.0
ICD-10 Finland
Psoriasis vulgaris
4.0
6.6
19
50
D05AX02
ATC
calcipotriol; topical
4.0
6.6
19
50
J01DB01
ATC
cefalexin; oral
2.1
6.3
283
2382
M04AA01
ATC
allopurinol; systemic
2.3
6.3
52
250
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
6.3
6
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
6.3
75
417
G47.3
ICD-10 Finland
Sleep apnoea
2.0
6.2
82
471
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.1
6.1
26
89
S01
ICPC
Pain/tenderness of skin
3.3
6.1
23
73
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.1
6.1
25
84
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
10.3
6.1
11
11
C03DA01
ATC
spironolactone; oral
2.3
6.1
51
247
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
6.0
55
275
AA1AD
NOMESCO Finland
CT of head and brain
1.9
6.0
100
620
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.6
6.0
37
155
D07XC01
ATC
betamethasone; topical
2.3
6.0
48
227

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
73
116
7.73
46.05
1.3
1.2
—
—
—
0
0
108
374
3.76
26.49
1.5
1.4
892.17
422.50
titre
0.86
23
80
243
1402
3.53
25.65
9.0
5.4
0.59
0.57
e9/l
0.75
221
1222
243
1405
3.52
25.50
9.1
5.4
0.04
0.04
e9/l
0.57
221
1227
245
1449
3.44
24.23
9.1
5.8
0.18
0.19
e9/l
0.68
224
1284
243
1443
3.36
23.59
9.1
5.5
1.84
1.89
e9/l
0.19
225
1295
74
212
4.18
23.54
2.2
2.8
66.86
66.09
g/l
0.35
68
190
227
1307
3.19
23.02
9.3
6.1
—
—
—
0
0
259
1646
3.36
21.43
12.3
8.7
4.41
4.11
e9/l
1.29
236
1454
63
184
3.97
19.32
2.2
2.3
—
—
—
0
0
211
1264
2.75
18.16
9.4
5.8
0.66
0.65
%
0.13
201
1181
216
1311
2.76
18.08
9.7
6.0
8.59
8.62
%
0.05
207
1235
214
1305
2.71
17.54
9.5
5.7
2.79
2.89
%
0.27
205
1227
216
1343
2.65
16.70
9.5
5.8
25.87
27.88
%
1.83
205
1267
214
1326
2.64
16.64
9.2
5.6
59.38
57.43
%
1.44
205
1250
197
1203
2.50
15.34
6.4
4.5
34.85
35.68
g/l
1.39
189
1126
29
54
5.78
15.23
1.5
1.5
—
—
—
0
0
81
347
2.75
12.96
8.3
5.6
1.07
1.04
mmol/l
0.27
75
316
84
372
2.67
12.56
3.5
2.3
21.74
22.07
%
0.05
76
320
211
1405
2.31
12.49
8.6
6.6
1.21
1.22
mmol/l
0.54
185
1187
127
707
2.27
11.34
9.1
6.6
—
—
—
0
0
127
707
2.27
11.34
3.4
2.7
4293.72
7177.80
umol/l
0.29
117
610
125
697
2.25
11.07
2.9
2.1
3.05
3.18
mg/l
0.30
111
587
148
886
2.18
10.97
6.1
3.7
7.40
7.40
ph
0.01
22
170
271
2067
2.50
10.91
6.6
4.0
16.80
11.93
mm/h
4.40
259
1890
216
1500
2.19
10.91
7.3
6.0
11.25
10.95
umol/l
0.20
206
1423
131
753
2.20
10.70
5.9
4.1
—
—
—
0
0
25
58
4.57
10.23
1.6
1.8
—
—
—
0
0
186
1246
2.08
9.98
14.4
9.4
0.00
0.00
e9/l
0.60
155
1030
188
1276
2.05
9.61
7.3
6.2
1.21
1.22
mmol/l
0.56
176
1157
28
77
3.87
9.20
2.5
3.7
125.93
138.19
mg/l
0.04
21
64
28
77
3.87
9.20
2.4
3.8
47.96
34.30
mg/l
0.69
21
64
118
686
2.10
9.09
5.2
3.7
85.70
90.78
%
0.98
118
669
107
601
2.14
9.01
4.0
2.6
3.96
5.95
e6/l
0.78
97
539
90
472
2.23
9.00
1.5
1.3
64.46
33.27
iu/ml
0.30
25
166
81
408
2.29
8.92
3.1
2.0
—
—
—
0
0
66
304
2.45
8.89
1.8
1.4
—
—
—
0
0
23
56
4.33
8.86
2.2
4.3
—
—
—
0
0
86
448
2.23
8.72
3.2
3.7
0.79
0.82
mmol/l
1.88
80
418
225
1665
2.03
8.64
5.3
5.0
6.64
6.68
mmol/l
0.13
217
1540
96
529
2.13
8.42
5.0
3.9
124.88
314.83
ng/l
1.28
86
411
132
822
1.99
8.27
5.0
3.7
16.35
11.45
mg/mmol
0.36
101
503
66
316
2.35
8.12
2.8
2.4
1.94
1.78
%
0.92
59
282
272
2183
2.20
8.06
12.0
7.1
83.07
77.13
u/l
1.37
263
2042
140
900
1.94
7.92
4.4
3.2
—
—
—
0
0
58
265
2.43
7.91
2.2
2.0
349.23
373.74
nmol/l
0.32
53
242
26
77
3.57
7.69
4.4
2.9
—
—
—
0
0
186
1322
1.89
7.67
21.5
12.9
1.35
1.25
inr
0.67
55
392
53
236
2.47
7.63
4.8
3.6
—
—
—
0
0
65
323
2.25
7.30
2.5
1.6
—
—
—
0
0
245
1926
1.96
7.20
7.2
4.3
—
—
—
0
0
122
775
1.89
6.98
4.3
3.1
103.07
241.01
mg/l
0.58
96
496
124
792
1.89
6.97
5.0
3.0
0.30
0.46
e6/l
0.53
101
600
133
870
1.87
6.93
5.1
3.2
76.57
122.22
e6/l
0.22
109
672
52
242
2.35
6.78
6.6
8.8
—
—
—
0
0
96
569
1.96
6.72
2.0
1.4
2.90
2.49
g/l
0.99
77
349
120
766
1.87
6.72
4.8
3.0
—
—
—
0
0
127
830
1.84
6.57
4.8
3.0
6.59
7.45
mmol/l
1.37
117
693
50
232
2.35
6.56
3.2
2.5
74.35
69.71
e9/l
0.41
35
185
15
23
6.77
6.41
2.0
1.2
—
—
—
0
0
61
311
2.17
6.40
3.1
2.9
8.57
6.45
umol/l
0.34
55
268
104
647
1.87
6.24
6.1
3.9
—
—
—
0
0
86
504
1.94
6.17
2.1
1.7
—
—
—
0
0
146
1013
1.77
6.09
6.1
3.7
45.67
78.90
e6/l
0.68
116
724
129
865
1.79
6.03
4.3
3.3
1797.94
1366.11
ng/l
0.63
118
730
88
526
1.91
5.93
1.9
1.7
1126.68
1258.92
nmol/l
0.75
70
386
98
607
1.86
5.92
1.9
1.9
1.47
1.15
mg/l
0.32
75
478
42
191
2.37
5.76
1.5
1.4
—
—
—
0
0
16
32
5.19
5.64
1.9
1.5
—
—
—
0
0
127
862
1.75
5.61
2.0
2.1
143.71
219.12
u/l
0.81
121
811
156
1128
1.70
5.45
5.4
3.7
5.57
5.92
ph
—
7
88
87
534
1.84
5.35
3.1
2.9
2.47
2.45
mmol/l
0.83
79
467
71
409
1.93
5.30
1.9
1.6
—
—
—
0
0
239
1954
1.74
5.17
4.7
3.9
—
—
—
0
0
17
50
3.53
5.09
1.5
1.3
—
—
—
0
0
26
100
2.73
5.02
1.5
2.7
19.72
21.93
s
1.54
18
90
156
1148
1.66
4.97
2.8
2.3
76.62
77.22
nmol/l
0.08
144
1014
251
2091
1.75
4.96
4.3
3.9
14.68
14.84
pmol/l
0.42
236
1865
91
579
1.78
4.94
4.2
3.1
481.78
546.54
mosm/kgh2o
2.35
77
489
128
898
1.68
4.88
2.6
2.4
62.06
61.70
u/l
0.01
121
835
75
452
1.84
4.86
1.6
1.3
4.90
12.53
u/ml
0.93
26
175
182
1399
1.64
4.85
5.7
4.0
0.00
0.00
estimate
0.50
37
310
184
1420
1.64
4.81
5.8
4.0
0.00
0.01
estimate
0.50
37
279
17
54
3.26
4.55
2.2
1.6
8240.83
26590.12
e6/l
0.87
12
41
130
931
1.64
4.51
3.4
3.3
2.35
2.36
mmol/l
0.16
120
815
181
1409
1.60
4.44
7.6
5.4
0.00
0.00
estimate
-0.00
38
287
43
222
2.07
4.35
4.8
4.4
0.11
0.17
%
0.32
19
69
41
209
2.09
4.28
4.3
4.2
0.26
0.62
%
1.13
19
67
61
358
1.86
4.27
1.4
1.4
—
—
—
0
0
309
2789
2.12
4.19
29.0
14.1
23.75
22.66
mg/l
0.26
272
2206
32
149
2.27
4.17
4.9
2.7
0.73
0.66
%
0.24
32
149
287
2529
1.84
4.17
5.5
4.7
1.85
1.93
mu/l
0.53
274
2284
45
240
2.01
4.17
4.7
4.2
0.55
0.96
%
1.37
22
87
62
373
1.81
4.01
5.5
6.0
103.40
104.15
mmol/l
0.71
62
373
15
50
3.09
3.73
1.2
1.4
251.13
262.10
u/ml
—
8
29
15
50
3.09
3.73
1.5
1.2
—
—
—
0
0
14
45
3.20
3.69
1.2
1.2
4.00
4.47
u/ml
—
5
17
147
1130
1.53
3.57
2.4
1.9
92.54
94.96
pmol/l
0.22
90
562
215
1800
1.52
3.43
3.7
3.1
64.04
46.24
u/l
1.87
204
1681
69
448
1.68
3.40
4.1
2.9
3.27
2.44
e6/l
0.26
42
254
39
213
1.94
3.39
5.0
4.4
0.00
0.16
%
0.66
15
61
143
1106
1.50
3.31
5.0
3.9
53.36
32.31
ng/l
0.65
114
798
15
54
2.86
3.30
2.7
2.4
—
—
—
0
0
44
253
1.85
3.28
2.8
2.5
28.54
29.42
u/l
0.10
37
209
13
39
3.42
3.26
2.2
1.5
—
—
—
0
0
59
372
1.71
3.24
1.1
1.2
—
—
—
0
0
14
49
2.94
3.23
1.6
1.5
—
—
—
0
0
117
880
1.50
3.05
2.9
2.3
—
—
—
0
0
7
12
5.93
3.03
1.3
1.2
164.60
130.63
iu/ml
—
7
12
92
664
1.53
2.90
1.8
1.5
19.47
21.29
nmol/l
0.59
80
548
16
65
2.53
2.83
2.1
2.0
127.80
131.62
g/l
—
10
47
29
153
1.98
2.80
5.1
2.7
1.13
1.30
%
0.51
29
153
18
78
2.38
2.79
1.7
1.4
282.09
308.74
ug/g
0.22
11
49
9
23
3.99
2.79
1.1
1.0
—
—
—
0
0
43
259
1.76
2.77
1.8
1.5
—
—
—
0
0
5
6
8.43
2.76
1.0
1.2
—
—
—
0
0
17
73
2.40
2.69
2.9
3.4
7.94
8.25
kpa
0.45
17
73
50
322
1.65
2.54
4.0
9.2
0.63
1.39
mmol/l
0.67
44
261
53
347
1.62
2.52
2.9
2.3
238.36
130.37
ug/g
0.52
47
278
9
26
3.53
2.50
1.2
1.2
—
—
—
0
0
9
26
3.53
2.50
1.4
1.2
—
—
—
0
0
14
57
2.52
2.48
4.1
3.4
—
—
—
0
0
11
38
2.96
2.43
1.3
1.1
—
—
—
0
0
9
27
3.39
2.41
1.6
2.5
—
—
—
0
0
102
778
1.44
2.40
6.6
4.3
0.00
0.00
estimate
-0.00
34
283
5
8
6.32
2.38
1.0
1.1
—
—
—
0
0
8
22
3.70
2.38
1.4
1.0
—
—
—
0
0
9
28
3.27
2.32
1.4
2.7
—
—
—
0
0
29
164
1.84
2.31
3.5
3.4
7.43
7.41
ph
—
6
20
139
1127
1.39
2.30
2.8
2.1
—
—
—
0
0
11
40
2.81
2.29
1.9
1.3
29.46
33.41
g/l
0.44
11
34
33
195
1.77
2.29
2.4
7.2
—
—
—
0
0
9
29
3.16
2.24
1.6
1.2
—
—
—
0
0
17
80
2.18
2.22
1.2
1.4
—
—
—
0
0
5
9
5.62
2.22
1.2
1.0
—
—
—
0
0
157
1306
1.37
2.20
3.0
2.6
—
—
—
0
0
10
36
2.83
2.15
1.3
1.1
—
—
—
0
0
48
320
1.58
2.13
4.1
9.2
5.10
5.14
kpa
0.08
48
305
48
320
1.58
2.13
4.1
9.2
10.58
12.03
kpa
1.88
48
305
16
75
2.19
2.12
3.4
2.7
24.87
24.91
mmol/l
0.01
16
75
9
31
2.95
2.08
1.6
1.2
—
—
—
0
0
82
617
1.43
2.05
6.4
4.5
1.02
1.02
kg/l
—
9
85
9
32
2.86
2.01
1.2
1.0
—
—
—
0
0
77
576
1.43
1.99
1.7
1.7
477.66
456.23
pmol/l
0.25
65
475
29
173
1.74
1.97
1.6
1.3
—
—
—
0
0
18
92
2.01
1.94
3.6
3.4
0.16
0.17
g/l
—
9
33
8
28
2.90
1.87
1.1
1.1
—
—
—
0
0
5
12
4.21
1.83
1.0
1.7
1.18
0.79
nmol/l
—
5
7
5
12
4.21
1.83
1.0
1.0
—
—
—
0
0
81
621
1.40
1.82
1.4
1.3
1.54
1.52
u/ml
0.01
25
172
20
109
1.89
1.81
1.5
1.2
—
—
—
0
0
22
124
1.83
1.80
6.0
4.7
—
—
—
0
0
306
2887
1.57
1.80
22.6
13.2
—
—
—
0
0
287
2680
1.44
1.70
5.3
4.6
6.05
5.95
mmol/l
0.64
275
2438
7
25
2.84
1.66
1.7
1.1
—
—
—
0
0
11
49
2.29
1.65
4.4
3.4
59.27
58.02
%
0.14
11
49
38
256
1.54
1.64
3.5
2.6
6.90
6.88
ug/l
0.00
32
223
321
3075
1.71
1.62
39.7
20.9
39.84
40.19
%
0.67
301
2887
321
3078
1.70
1.57
40.0
20.8
7.10
6.73
e9/l
2.09
316
2990
6
21
2.89
1.51
1.2
2.6
—
—
—
0
0
39
272
1.49
1.45
3.2
9.2
120.90
121.41
g/l
0.06
39
264
18
103
1.79
1.44
1.6
1.6
—
—
—
0
0
36
248
1.50
1.42
1.9
1.5
—
—
—
0
0
292
2758
1.40
1.40
5.6
5.0
2.45
2.72
mmol/l
6.54
276
2526
7
29
2.44
1.40
2.4
2.6
—
—
—
0
0
14
243
0.56
1.33
1.2
1.4
—
—
—
0
0
12
62
1.97
1.29
2.9
2.8
—
—
—
0
0
272
2551
1.32
1.29
7.2
5.7
41.24
39.96
mmol/mol
1.31
258
2377
10
48
2.12
1.29
4.7
3.0
4.16
4.50
e9/l
—
10
48
28
187
1.54
1.28
2.7
1.9
9.04
13.40
nmol/l
2.06
23
175
17
100
1.74
1.26
1.8
2.8
—
—
—
0
0
6
25
2.42
1.25
1.2
1.3
—
—
—
0
0
6
25
2.42
1.25
1.0
1.1
—
—
—
0
0
19
116
1.68
1.24
3.8
3.4
—
—
—
0
0
87
718
1.28
1.18
1.9
1.7
1.36
1.34
mmol/l
0.07
73
590
8
155
0.50
1.16
1.6
1.4
—
—
—
0
0
8
39
2.08
1.16
2.1
1.1
—
—
—
0
0
7
31
2.28
1.11
1.0
1.5
—
—
—
0
0
12
66
1.85
1.10
2.4
2.6
95.99
80.07
ug/min
—
7
42
5
21
2.40
1.09
2.4
1.9
37.70
33.32
%
—
5
21
7
32
2.21
1.08
1.9
1.3
—
—
—
0
0
282
2678
1.30
1.07
4.9
4.4
1.44
1.48
mmol/l
0.91
269
2452
34
247
1.42
1.06
5.8
4.0
—
—
—
0
0
33
241
1.41
1.01
3.7
3.4
1.25
1.23
mmol/l
0.52
28
211
283
2694
1.29
1.01
5.1
4.5
4.34
4.62
mmol/l
5.91
272
2483
7
35
2.02
1.00
1.1
1.0
1.52
1.45
g/l
—
7
30
13
76
1.74
1.00
1.2
1.3
146.43
274.28
miu/ml
—
7
40
14
84
1.70
0.99
1.4
1.1
—
—
—
0
0
17
108
1.60
0.98
2.1
1.8
—
—
—
0
0
33
245
1.38
0.93
5.8
3.9
—
—
—
0
0
10
55
1.84
0.93
2.2
2.9
35.87
34.79
umol/l
—
10
47
15
97
1.57
0.83
13.9
11.1
—
—
—
0
0
0
26
0.00
0.78
0.0
1.4
—
—
—
0
0
41
325
1.30
0.78
1.7
1.3
—
—
—
0
0
26
193
1.38
0.76
1.7
1.4
—
—
—
0
0
27
203
1.36
0.73
1.2
1.2
—
—
—
0
0
38
302
1.29
0.72
3.7
4.3
3.68
41.99
ug/l
0.86
28
255
7
40
1.77
0.71
1.7
1.6
—
—
—
0
0
10
61
1.66
0.69
1.2
1.2
—
—
—
0
0
5
27
1.86
0.68
1.4
1.3
—
—
—
0
0
19
139
1.39
0.62
2.8
13.8
—
—
—
0
0
8
51
1.58
0.61
2.5
2.8
—
—
—
0
0
8
51
1.58
0.61
1.4
1.8
120.00
204.35
e6/l
—
8
43
0
20
0.00
0.60
0.0
1.5
—
—
—
0
0
20
149
1.36
0.59
2.6
2.6
—
—
—
0
0
6
35
1.73
0.58
3.2
1.5
32.83
33.29
pg
—
6
35
90
805
1.16
0.56
4.9
4.1
—
—
—
0
0
269
2596
1.17
0.55
4.5
4.0
1.30
1.27
mmol/l
0.33
253
2363
9
60
1.51
0.54
6.6
3.6
7.42
7.37
mmol/l
—
9
60
42
353
1.22
0.52
1.5
1.3
—
—
—
0
0
16
118
1.37
0.51
1.1
1.1
—
—
—
0
0
9
65
1.39
0.51
2.4
2.6
—
—
—
0
0
14
103
1.37
0.46
1.2
1.1
—
—
—
0
0
5
33
1.52
0.41
2.2
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
7.30
—
0
16
0
18
0.00
0.40
0.0
16.7
—
1250.22
—
0
18
24
197
1.23
0.39
5.3
9.1
24.50
24.60
mmol/l
0.06
24
186
5
37
1.36
0.37
1.0
2.0
—
—
—
0
0
5
37
1.36
0.37
2.6
3.3
—
—
—
0
0
6
41
1.47
0.36
4.0
1.8
—
—
—
0
0
6
42
1.44
0.35
1.0
1.1
—
—
—
0
0
6
42
1.44
0.35
1.0
1.1
—
—
—
0
0
6
44
1.37
0.34
1.2
1.2
—
—
—
0
0
18
145
1.25
0.34
5.4
3.9
—
—
—
0
0
7
53
1.33
0.31
1.3
1.9
6.35
4.58
mmol/24h
—
7
48
85
789
1.10
0.30
4.5
3.6
—
—
—
0
0
54
491
1.12
0.28
3.0
3.1
0.85
0.72
ug/l
0.25
42
330
27
307
0.87
0.25
1.6
1.7
—
—
—
0
0
88
827
1.09
0.25
5.1
5.0
2.37
2.43
ug/l
0.05
82
732
5
41
1.22
0.22
8.2
3.0
4.12
4.03
mmol/l
—
5
41
5
41
1.22
0.22
8.0
3.0
—
—
—
0
0
5
41
1.22
0.22
8.2
3.0
104.40
105.88
mmol/l
—
5
41
0
11
0.00
0.21
0.0
1.1
—
0.20
—
0
6
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.32
—
0
5
5
43
1.17
0.21
2.2
3.1
—
—
—
0
0
5
43
1.17
0.21
1.8
1.4
—
—
—
0
0
5
43
1.17
0.21
1.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
21
184
1.15
0.19
3.7
3.2
—
—
—
0
0
13
109
1.20
0.19
1.0
1.0
—
—
—
0
0
6
53
1.13
0.19
1.0
1.1
—
—
—
0
0
28
255
1.11
0.15
1.8
1.6
—
—
—
0
0
21
230
0.91
0.12
1.3
1.4
—
—
—
0
0
18
164
1.10
0.10
1.3
1.3
—
—
—
0
0
5
48
1.04
0.09
1.4
1.2
—
—
—
0
0
6
55
1.09
0.09
18.8
1.4
—
—
—
0
0
5
63
0.79
0.08
3.6
3.5
17.00
30.87
u/ml
—
5
63
8
77
1.04
0.07
1.3
1.4
—
—
—
0
0
93
950
0.97
0.06
2.9
2.9
—
—
—
0
0
78
794
0.98
0.04
1.5
1.4
—
—
—
0
0
12
114
1.05
0.00
1.1
1.9
—
—
—
0
0
19
188
1.01
0.00
1.3
1.2
123.50
156.33
iu/ml
—
6
69
8
81
0.99
-0.00
1.8
1.4
—
—
—
0
0
8
87
0.92
-0.00
1.8
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
-0.00
7.6
4.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.2
—
—
—
0
0
8
85
0.94
-0.00
1.7
1.4
—
—
—
0
0
7
71
0.99
-0.00
1.7
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
87
0.92
-0.00
1.8
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
37.20
—
0
5
0
6
0.00
-0.00
0.0
8.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
87
0.92
-0.00
1.8
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
19.39
—
0
7
7
72
0.97
-0.00
1.1
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint D3_OTHNONTHROMBOCYTOPENPURPURA and mortality.

Females

Parameter HR [95% CI] p-value
D3_OTHNONTHROMBOCYTOPENPURPURA 1.597 [1.33, 1.92] < 0.001
Birth year 0.993 [0.98, 1.0] 0.101

During the follow-up period (1.1.1998 — 31.12.2019), 289 out of 1034 females with D3_OTHNONTHROMBOCYTOPENPURPURA died.

Males

Parameter HR [95% CI] p-value
D3_OTHNONTHROMBOCYTOPENPURPURA 2.141 [1.7, 2.7] < 0.001
Birth year 0.99 [0.98, 1.0] 0.028

During the follow-up period (1.1.1998 — 31.12.2019), 268 out of 813 males with D3_OTHNONTHROMBOCYTOPENPURPURA died.

Mortality risk

Mortality risk for people of age

years, who have D3_OTHNONTHROMBOCYTOPENPURPURA.

N-year risk Females Males
1 0.141% 0.389%
5 0.854% 2.614%
10 2.273% 6.654%
15 4.128% 12.93%
20 7.356% 21.529%

Relationships between endpoints

↥

Index endpoint: D3_OTHNONTHROMBOCYTOPENPURPURA – Other nonthrombocytopenic purpura

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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