hypothyroidism: Abnormally low levels of thyroid hormone.
Hypothyroidism due to medicaments and other exogenous substances
DOID EFO Endpoint Browser PheWeb
E4_HYTHYSUBS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
420 |
4. Check minimum number of eventsNone |
420 |
5. Include endpointsNone |
420 |
6. Filter based on genotype QC (FinnGen only) |
406 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E03
- Name in latin
- Hypothyreosis ex medicamentis sive aliis substantiis externis
Similar endpoints
↥List of similar endpoints to
Hypothyroidism due to medicaments and other exogenous substances
based on the number of shared cases.
Similar with more cases:
- Hypothyroidism (congenital or acquired)
- Hypothyreosis and Thyroxine purchase for inclusion criteria
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2311 | 1701 | 600 |
| Only index persons | 2080 | 1546 | 534 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 61.87 | 61.63 | 62.70 |
| Only index persons | 60.73 | 60.33 | 61.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 406 | 292 | 114 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.05 |
| Median age at first event (years) | 59.70 | 57.91 | 64.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 420
- Matched controls
- 4200
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
2655.3
307.7
409
58
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
+∞
307.7
403
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
296.4
307.7
174
10
H03BB01
ATC
carbimazole; oral
885.7
217.1
195
*
104
Kela drug reimbursment
Thyroid insufficiency
665.8
147.1
137
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
140.8
127
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
476.6
110.9
106
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
70.9
66
*
C01BD01
ATC
amiodarone; systemic
14.9
51.9
48
36
E03
ICD-10 Finland
Other hypothyroidism
188.6
49.0
50
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
175.9
45.8
47
*
T86
ICPC
Hypothyroidism/myxoedema
171.7
44.8
46
*
N05AN01
ATC
lithium; oral
11.8
34.2
36
33
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
33.8
32
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
31.7
30
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
92.2
23.9
26
*
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
88.5
22.9
25
*
C07AA05
ATC
propranolol; systemic
3.0
21.7
129
545
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
19.9
19
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
209.5
19.7
20
*
C07AB07
ATC
bisoprolol; oral
2.5
19.2
245
1492
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.4
19.0
52
132
BAA60
NOMESCO Finland
Total thyroidectomy
99.3
17.7
19
*
2443X
ICD-9 Finland
Acquired hypothyroidism, Other iatrogenic hypothyroidism
+∞
16.8
16
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
176.7
16.6
17
*
130
Kela drug reimbursment
Malignant tumour
3.5
16.2
61
194
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
7.2
15.9
24
35
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
15.7
15
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.4
15.3
40
98
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
6.8
15.1
24
37
3012
Kela drug reimbursment
Cabozantinib
58.9
14.9
17
*
1502
Kela drug reimbursment
Cabozantinib
58.9
14.9
17
*
N05AF03
ATC
chlorprothixene; systemic
6.9
14.6
23
35
ZX120
NOMESCO Finland
Intravenous
3.3
14.5
61
208
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
13.8
219
1398
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
13.6
13
*
C03CA01
ATC
furosemide; systemic
2.2
12.6
144
800
C03DA01
ATC
spironolactone; oral
2.8
12.3
70
282
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
16.5
12.3
19
12
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.4
12.2
97
460
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
12.1
84
375
TPH07
NOMESCO Finland
Cathetrisation of artery
2.8
11.8
64
251
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
31.0
11.7
15
5
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
11.5
11
*
L01XE26
ATC
[U] cabozantinib
+∞
11.5
11
*
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
13.2
11.2
19
15
XF400
NOMESCO Finland
ECG with 12 standard connections
2.5
11.1
81
369
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
4.2
10.9
30
76
N05AX12
ATC
aripiprazole; systemic
4.9
10.8
24
51
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
10.8
81
373
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
5.2
10.6
22
44
H02AB06
ATC
prednisolone; systemic
2.0
10.6
214
1446
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
10.5
10
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
16.6
10.4
16
10
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
24.1
10.3
14
6
WX892
NOMESCO Finland
Monitored bed care
3.2
10.2
43
146
C07AA07
ATC
sotalol; systemic
4.5
10.2
25
58
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
10.4
10.1
19
19
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
10.0
33
96
JN4CD
NOMESCO Finland
Very extensive body CT
4.5
9.7
24
56
N05AH03
ATC
olanzapine; systemic
3.3
9.6
38
124
Z2221
NOMESCO Finland
Medical doctor
2.0
9.2
134
800
L01EX07
ATC
cabozantinib; oral
37.6
9.1
11
*
B01AB05
ATC
enoxaparin; parenteral
1.9
9.0
149
930
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
24.6
9.0
12
5
N03AG01
ATC
valproic acid; systemic, rectal
3.2
8.9
36
119
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
12.9
8.9
15
12
Z3231
NOMESCO Finland
Registered nurse
2.0
8.9
131
785
A03FA01
ATC
metoclopramide; systemic, rectal
2.0
8.8
113
645
ZXE00
NOMESCO Finland
One hour or less
1.9
8.6
178
1188
R50.9
ICD-10 Finland
Fever, unspecified
2.3
8.5
73
355
T85
ICPC
Hyperthyroidism/thyrotoxicosis
91.8
8.4
9
*
N03AX09
ATC
lamotrigine; oral
3.6
8.4
28
82
168
Kela drug reimbursment
Axitinib
+∞
8.4
8
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
8.3
105
594
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
8.3
102
572
B01AA03
ATC
warfarin; systemic
2.2
8.2
82
424
ZXD05
NOMESCO Finland
Urgent procedure
1.9
8.1
140
880
R31
ICD-10 Finland
Unspecified haematuria
2.7
8.1
45
179
ZY010
NOMESCO Finland
Hospital outpatient
3.3
8.0
31
100
B01AB04
ATC
dalteparin; parenteral
3.3
8.0
31
100
N05AA02
ATC
levomepromazine; systemic
3.6
7.9
26
75
Z3226
NOMESCO Finland
Physiotherapist
2.1
7.9
89
481
H02AB09
ATC
hydrocortisone; systemic
6.3
7.9
20
33
N03AE01
ATC
clonazepam; systemic
3.2
7.8
31
102
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
7.7
173
1175
TFP20
NOMESCO Finland
Cardiodefibrillation
2.9
7.7
37
136
JN4AD
NOMESCO Finland
Body CT examination
2.5
7.6
51
222
ZYC01
NOMESCO Finland
Remote contact by phone
2.9
7.5
35
126
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
7.0
7.4
17
25
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
7.4
163
1100
L01EK01
ATC
axitinib; oral
+∞
7.3
7
*
197
Kela drug reimbursment
Sunitinib
30.6
7.2
9
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
3.8
7.1
22
61
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.0
7.1
94
538
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
4.3
7.1
18
43
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.1
7.0
29
98
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
6.9
6.9
16
24
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.3
6.8
26
83
159
Kela drug reimbursment
Pazopanib
40.7
6.8
8
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
17.0
6.8
10
6
I47.2
ICD-10 Finland
Ventricular tachycardia
5.7
6.7
18
33
N05BA04
ATC
oxazepam; oral
1.8
6.7
120
757
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
6.7
62
311
WF049
NOMESCO Finland
Radiotherapy of metastasis
3.6
6.7
22
64
N02BE01
ATC
paracetamol; systemic, rectal
2.3
6.6
378
3334
A28
ICPC
Limited function/disability NOS
2.0
6.5
77
424
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
6.4
39
162
WZC30
NOMESCO Finland
Teaching
2.0
6.4
72
388
WX402
NOMESCO Finland
General anaesthesia
1.9
6.4
94
556
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.6
6.4
21
61
F31.8
ICD-10 Finland
Other bipolar affective disorders
6.1
6.4
16
27
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.0
6.3
75
412
N05AD01
ATC
haloperidol; systemic
4.0
6.3
18
47
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
9.5
6.3
12
13
N05CD07
ATC
temazepam; oral
2.2
6.3
57
283
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
7.2
6.3
14
20
361
Kela drug reimbursment
Axitinib
+∞
6.3
6
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
5.9
6.2
16
28
N05AH04
ATC
quetiapine; oral
2.0
6.2
77
430
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.3
6.2
49
230
C64
ICD-10 Finland
Malignant neoplasm of kidney, except renal pelvis
8.8
6.1
12
14
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.1
6.1
25
84
I50.9
ICD-10 Finland
Heart failure, unspecified
2.1
6.0
61
316
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
185
107
30.11
241.27
6.1
1.5
4.36
4.49
pmol/l
0.42
170
95
119
38
43.30
189.77
2.7
1.2
6.44
1.19
iu/l
—
56
9
93
176
6.50
49.29
1.3
1.2
273.11
75.36
iu/ml
0.85
44
60
402
2585
13.95
43.27
13.9
2.5
15.72
14.46
pmol/l
16.17
387
2320
104
284
4.54
35.61
5.6
1.8
398.72
362.49
nmol/l
0.97
99
257
288
1677
3.28
28.73
9.9
6.0
1.22
1.22
mmol/l
0.04
243
1426
270
1524
3.16
28.26
8.6
5.2
1.22
1.22
mmol/l
0.12
253
1385
134
543
3.16
24.66
5.3
2.7
0.81
0.82
mmol/l
0.30
128
512
78
260
3.46
19.42
8.4
5.9
9.51
9.33
mmol/l
0.09
73
246
236
1414
2.53
19.17
2.8
2.2
75.12
77.28
nmol/l
0.59
215
1259
402
3207
6.92
18.99
15.6
3.4
2.61
1.89
mu/l
2.95
389
2902
296
1999
2.63
18.22
17.9
8.9
3.93
4.11
e9/l
0.72
255
1746
202
1157
2.44
17.69
5.5
3.3
2.35
2.36
mmol/l
0.27
180
1021
255
1665
2.35
15.99
9.1
5.7
26.54
28.29
%
1.71
237
1555
71
251
3.20
15.93
3.7
3.2
77.23
75.75
ng/l
0.06
64
225
251
1648
2.30
15.26
9.1
5.4
58.02
56.99
%
0.62
233
1540
225
1439
2.21
14.23
6.8
4.2
34.89
35.54
g/l
0.95
209
1348
101
467
2.53
13.58
2.7
2.1
2.36
2.34
g/l
0.13
95
427
97
444
2.54
13.30
2.7
2.1
20.14
23.16
%
1.22
84
390
347
2718
2.59
12.70
13.7
7.1
78.19
77.85
u/l
0.07
334
2549
275
1965
2.16
12.40
7.5
4.3
6.96
6.61
mmol/l
1.33
263
1842
104
514
2.36
11.95
2.8
2.1
12.03
13.21
umol/l
1.08
98
472
259
1829
2.09
11.79
10.9
5.9
10.07
11.07
umol/l
1.23
249
1739
119
632
2.23
11.49
5.2
3.5
521.60
285.83
ng/l
0.26
96
478
180
1127
2.05
11.27
4.7
3.1
27.52
30.95
u/l
1.55
170
1078
300
2272
2.12
10.88
6.2
4.4
545.17
2136.49
e6/l
—
6
39
221
1511
1.98
10.58
3.5
2.6
130.44
113.80
ug/l
0.55
203
1389
117
637
2.16
10.51
4.4
2.8
2.48
2.46
mmol/l
1.03
98
553
159
973
2.02
10.43
3.6
3.0
1805.53
1120.17
ng/l
1.43
146
826
20
22
9.49
10.12
3.2
1.8
17.26
22.95
nmol/l
1.06
20
22
227
1588
1.93
9.94
18.7
12.8
1.27
1.20
inr
0.38
69
461
67
301
2.46
9.38
4.6
3.4
1.63
2.00
mmol/l
0.50
56
245
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
27
72
3.94
9.21
3.5
2.4
0.28
0.36
u/ml
0.70
13
37
153
958
1.94
9.16
5.0
2.9
0.26
0.47
e6/l
1.14
115
703
185
1235
1.89
9.10
5.2
2.9
—
—
—
0
0
78
385
2.26
8.80
1.9
1.8
—
—
—
0
0
162
1048
1.89
8.69
5.4
3.0
57.19
127.22
e6/l
0.50
125
789
165
1079
1.87
8.52
5.1
2.3
59.13
60.51
u/l
0.11
157
1006
78
393
2.21
8.35
2.0
1.8
—
—
—
0
0
66
314
2.31
8.09
2.7
2.3
27.81
29.37
u/l
0.33
58
261
136
850
1.89
7.99
3.0
2.0
2.73
3.10
mg/l
0.92
116
730
98
552
2.01
7.80
2.0
1.9
—
—
—
0
0
119
717
1.92
7.79
3.5
2.4
6.11
5.54
e6/l
0.20
103
639
95
533
2.01
7.63
5.0
2.7
2.96
2.48
e6/l
0.18
56
269
320
2618
1.93
7.60
5.0
3.9
16.48
12.06
mm/h
3.67
297
2402
132
829
1.86
7.58
1.6
1.5
20.57
21.67
nmol/l
0.41
118
700
193
1366
1.76
7.41
2.3
2.0
92.39
95.86
pmol/l
0.41
105
691
230
1712
1.76
7.40
4.8
3.7
0.00
0.00
estimate
0.50
62
356
71
362
2.16
7.34
7.0
7.0
5.00
5.12
kpa
0.69
66
344
71
362
2.16
7.34
7.0
7.0
12.25
12.16
kpa
0.05
66
345
71
368
2.12
7.03
7.0
6.9
0.35
1.38
mmol/l
1.70
55
292
183
1292
1.74
6.97
5.7
3.7
28.70
59.94
ng/l
0.59
142
903
19
48
4.10
6.97
5.1
4.5
365.36
360.31
umol/l
0.03
14
42
391
3490
2.74
6.84
25.4
13.2
21.74
22.85
mg/l
0.35
343
2715
54
255
2.28
6.71
3.2
2.8
184.56
191.87
ng/l
0.07
48
225
230
1746
1.70
6.60
4.9
3.7
0.00
0.01
estimate
0.50
56
324
95
561
1.90
6.50
4.6
2.6
1.09
1.19
e6/l
0.09
56
297
227
1724
1.69
6.45
6.4
5.0
0.00
0.00
estimate
0.50
58
339
46
208
2.36
6.31
1.8
1.6
—
—
—
0
0
396
3592
2.79
6.04
30.2
15.2
3.99
3.96
mmol/l
1.26
391
3485
47
219
2.29
6.03
1.6
1.6
—
—
—
0
0
352
3055
1.94
5.93
33.4
15.9
14.53
15.00
%
1.23
347
3013
149
1031
1.69
5.88
4.9
3.0
7.01
7.21
mmol/l
0.21
132
864
144
1016
1.64
5.15
5.5
3.7
14.22
7.81
mg/mmol
0.84
97
621
146
1034
1.63
5.14
2.5
2.0
179.12
258.67
u/l
0.57
137
977
117
787
1.67
5.02
1.9
1.7
1.73
1.13
mg/l
0.83
86
624
21
72
3.02
4.94
3.6
2.4
19.20
16.23
%
1.64
12
38
62
350
1.91
4.80
3.9
3.2
—
—
—
0
0
17
52
3.36
4.80
1.2
1.6
—
—
—
0
0
122
847
1.62
4.57
2.6
2.5
336.37
7782.86
umol/l
4.16
101
754
64
371
1.86
4.57
3.7
2.7
5.54
8.02
umol/l
1.29
53
320
205
1612
1.53
4.42
2.8
2.5
—
—
—
0
0
117
810
1.62
4.42
2.6
2.2
—
—
—
0
0
40
202
2.08
4.23
1.7
1.4
—
—
—
0
0
23
91
2.62
4.20
2.0
1.4
—
—
—
0
0
15
47
3.27
4.09
1.6
1.3
—
—
—
0
0
399
3728
2.41
3.95
18.2
10.1
25.45
24.73
u/l
0.43
394
3600
22
88
2.58
3.95
6.4
4.0
1.66
1.56
mg/l
0.23
22
80
131
957
1.54
3.86
1.8
1.6
1.44
1.34
mmol/l
0.62
113
800
15
49
3.14
3.84
1.4
1.3
113.00
119.58
u/ml
—
5
12
24
103
2.41
3.74
2.7
3.9
32.55
26.47
mg/l
0.41
19
79
395
3694
2.16
3.59
31.2
15.6
81.79
74.09
umol/l
3.84
395
3694
32
159
2.10
3.55
1.6
1.4
25.47
27.18
iu/l
0.11
27
137
9
17
5.38
3.53
1.9
1.9
70.79
51.86
ug/l
—
9
17
88
600
1.59
3.48
1.9
1.7
1121.75
1264.20
nmol/l
0.88
72
437
23
101
2.35
3.42
2.7
3.8
—
2.90
—
0
9
16
59
2.78
3.36
1.3
1.8
—
—
—
0
0
23
103
2.30
3.28
2.7
3.9
70.12
120.12
mg/l
0.30
18
80
20
86
2.39
3.13
1.4
1.7
—
—
—
0
0
20
87
2.36
3.05
1.3
1.7
—
—
—
0
0
13
45
2.95
3.05
1.6
1.1
1.86
1.58
u/ml
—
7
12
360
3311
1.61
2.96
25.5
12.3
77.48
80.91
ml/min/173m2
2.10
324
2699
19
84
2.32
2.81
1.1
1.3
—
—
—
0
0
13
48
2.76
2.74
1.4
1.3
0.60
0.58
nmol/l
0.07
13
42
14
54
2.65
2.73
1.3
1.2
—
—
—
0
0
6
10
6.07
2.70
1.3
1.4
407.50
113.90
iu/ml
—
6
10
83
591
1.50
2.68
1.3
1.3
11.02
7.08
u/ml
0.22
26
220
12
42
2.91
2.57
1.3
1.7
90.91
90.72
%
0.05
12
42
260
2274
1.38
2.56
3.5
3.0
52.48
45.95
u/l
0.62
246
2115
404
3867
2.17
2.50
39.5
19.6
39.65
39.72
%
0.09
380
3626
15
63
2.43
2.49
2.9
3.0
3.78
4.68
e9/l
1.38
15
63
404
3870
2.15
2.44
39.2
19.6
4.38
4.45
e12/l
2.00
398
3757
6
12
5.05
2.41
1.0
1.0
—
—
—
0
0
12
46
2.66
2.38
3.8
1.8
31.17
32.17
pg
0.27
12
46
162
1332
1.35
2.30
5.2
3.9
—
—
—
0
0
33
194
1.76
2.30
5.0
4.4
2.06
1.88
mmol/l
0.09
23
150
11
40
2.80
2.29
1.1
1.8
—
—
—
0
0
85
628
1.44
2.28
1.3
1.3
17.14
30.58
iu/ml
1.96
21
215
15
66
2.32
2.27
2.9
3.5
58.20
58.71
%
0.06
15
66
24
128
1.93
2.26
3.9
1.7
—
—
—
0
0
18
86
2.14
2.26
1.4
1.2
—
—
—
0
0
19
94
2.07
2.19
2.6
2.4
—
—
—
0
0
16
74
2.21
2.17
1.4
1.3
—
—
—
0
0
364
3410
1.51
2.16
5.7
4.5
6.05
5.90
mmol/l
1.32
336
3106
9
30
3.04
2.16
1.1
1.9
—
—
—
0
0
11
42
2.66
2.16
1.1
1.1
—
15.88
—
0
8
6
15
4.04
2.04
2.0
2.3
111.33
99.53
%
—
6
15
19
97
2.00
2.03
1.2
1.4
0.30
0.23
g/l
2.28
19
91
10
38
2.67
2.01
1.3
1.7
—
—
—
0
0
7
21
3.37
1.97
2.3
2.8
—
—
—
0
0
346
3225
1.41
1.97
6.8
5.6
41.68
39.64
mmol/mol
2.72
327
3005
9
33
2.76
1.94
1.2
1.8
—
—
—
0
0
16
78
2.09
1.93
1.4
1.2
—
—
—
0
0
7
22
3.22
1.88
1.1
1.8
—
—
—
0
0
16
298
0.52
1.84
1.9
1.8
—
—
—
0
0
6
17
3.56
1.84
1.2
1.2
—
—
—
0
0
7
23
3.08
1.80
1.1
1.8
—
—
—
0
0
19
102
1.90
1.79
1.2
1.4
1.30
1.19
g/l
0.88
19
95
116
939
1.33
1.77
6.3
3.8
0.00
0.00
estimate
0.50
59
333
372
3530
1.47
1.75
5.7
4.9
2.69
2.79
mmol/l
1.20
347
3251
41
277
1.53
1.72
5.2
2.6
54.70
64.67
ml/min/173m2
1.45
23
110
53
381
1.45
1.66
2.3
1.8
1.44
1.47
%
0.18
44
335
7
25
2.83
1.65
1.1
1.8
—
—
—
0
0
10
41
2.47
1.65
1.4
1.4
—
—
—
0
0
10
41
2.47
1.65
1.4
1.4
—
—
—
0
0
11
49
2.28
1.65
1.2
1.2
13.70
14.61
u/l
0.12
11
43
10
42
2.41
1.62
1.9
1.9
14.75
22.11
ug/l
—
10
42
10
43
2.36
1.60
1.4
1.1
—
—
—
0
0
11
50
2.23
1.58
1.1
1.6
—
—
—
0
0
95
762
1.32
1.54
1.3
1.2
1.98
2.20
u/ml
0.05
24
205
10
45
2.25
1.47
1.5
1.1
5.20
2.27
u/ml
—
5
15
5
16
3.15
1.44
1.4
1.1
—
—
—
0
0
5
17
2.96
1.36
1.6
1.6
—
—
—
0
0
352
3341
1.33
1.36
4.5
3.8
1.41
1.25
mmol/l
1.94
327
3057
18
105
1.75
1.35
2.0
1.6
—
—
—
0
0
13
68
1.94
1.34
1.2
1.6
—
—
—
0
0
238
2162
1.23
1.32
3.2
3.0
—
—
—
0
0
363
3465
1.35
1.31
5.2
4.3
4.57
4.74
mmol/l
2.26
341
3216
9
43
2.12
1.31
3.2
1.3
—
—
—
0
0
12
62
1.96
1.29
1.3
1.6
—
—
—
0
0
5
18
2.80
1.29
2.4
1.7
—
—
—
0
0
17
100
1.73
1.25
1.4
1.5
0.00
0.16
iu/ml
—
7
20
89
728
1.28
1.25
1.8
1.7
454.60
20672699.57
pmol/l
0.78
75
595
10
50
2.02
1.17
1.2
1.6
—
—
—
0
0
0
33
0.00
1.16
0.0
1.1
—
—
—
0
0
11
58
1.92
1.13
1.5
1.5
—
—
—
0
0
11
58
1.92
1.13
1.5
1.5
—
—
—
0
0
11
58
1.92
1.13
1.2
1.6
—
—
—
0
0
15
89
1.71
1.09
1.1
1.4
—
—
—
0
0
16
97
1.68
1.08
3.3
1.9
197.71
549.44
u/l
—
8
37
5
22
2.29
1.03
1.8
1.4
62.20
71.14
umol/l
—
5
22
359
3447
1.29
1.03
5.0
4.3
1.44
1.53
mmol/l
3.40
334
3180
49
380
1.33
1.03
3.5
4.1
19.97
9.75
ug/l
0.25
41
312
0
30
0.00
0.97
0.0
1.2
—
—
—
0
0
9
52
1.75
0.93
1.1
1.1
—
—
—
0
0
6
28
2.16
0.92
1.0
1.1
—
—
—
0
0
6
28
2.16
0.92
1.0
1.1
—
—
—
0
0
6
29
2.08
0.89
1.0
1.1
—
—
—
0
0
6
29
2.08
0.89
1.0
1.1
—
—
—
0
0
6
29
2.08
0.89
1.0
1.1
—
—
—
0
0
8
44
1.83
0.86
1.0
1.2
—
—
—
0
0
17
112
1.54
0.86
1.2
1.1
—
—
—
0
0
17
112
1.54
0.86
1.2
1.1
—
—
—
0
0
87
744
1.21
0.84
5.8
4.0
1.02
1.02
kg/l
—
10
99
11
65
1.71
0.83
1.0
1.2
—
—
—
0
0
11
65
1.71
0.83
1.0
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
6
33
1.83
0.79
1.0
1.4
—
—
—
0
0
7
123
0.56
0.79
1.4
1.4
—
—
—
0
0
20
140
1.45
0.78
1.8
1.7
—
—
—
0
0
5
24
2.10
0.74
1.0
1.0
—
—
u/ml
—
0
0
13
84
1.57
0.72
1.6
1.3
653.69
497.53
mg/l
0.41
13
79
5
27
1.86
0.68
1.2
1.1
—
—
—
0
0
5
27
1.86
0.68
1.0
1.2
—
—
—
0
0
5
28
1.79
0.66
2.4
1.4
1.43
2.82
ug/l
—
5
22
5
28
1.79
0.66
1.8
1.7
—
—
—
0
0
5
28
1.79
0.66
1.8
1.7
—
—
—
0
0
5
28
1.79
0.66
1.8
1.7
—
—
—
0
0
7
44
1.60
0.65
1.0
1.0
—
—
—
0
0
5
29
1.73
0.64
2.8
2.1
—
—
—
0
0
8
49
1.64
0.62
3.9
3.7
29.50
78.14
u/ml
—
8
49
19
139
1.38
0.61
1.3
1.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
8
52
1.55
0.59
1.4
1.7
—
—
—
0
0
13
90
1.46
0.56
1.1
1.1
—
—
—
0
0
11
74
1.50
0.54
1.1
1.2
—
—
—
0
0
7
46
1.53
0.48
1.7
1.7
—
—
—
0
0
7
47
1.50
0.48
1.0
1.1
—
—
—
0
0
7
47
1.50
0.48
1.9
1.3
—
—
—
0
0
7
48
1.47
0.47
1.9
1.3
—
—
—
0
0
7
48
1.47
0.47
1.9
1.3
—
—
—
0
0
7
48
1.47
0.47
1.9
1.3
—
—
—
0
0
7
48
1.47
0.47
1.9
1.3
—
—
—
0
0
7
48
1.47
0.47
1.4
1.5
—
—
—
0
0
7
48
1.47
0.47
1.9
1.3
—
—
—
0
0
22
175
1.27
0.44
2.1
1.8
—
—
—
0
0
7
51
1.38
0.44
1.3
1.1
—
—
—
0
0
69
616
1.14
0.43
1.5
1.4
—
—
—
0
0
12
87
1.39
0.42
1.2
1.5
264.67
308.13
ug/g
—
6
49
11
79
1.40
0.41
1.5
1.5
—
—
—
0
0
88
807
1.11
0.37
3.7
5.0
1.65
2.91
ug/l
1.86
76
722
11
81
1.37
0.36
1.5
1.3
—
—
—
0
0
6
42
1.43
0.35
4.3
4.5
—
—
—
0
0
11
84
1.32
0.30
1.7
1.4
—
—
—
0
0
10
77
1.31
0.26
1.6
1.2
4.66
3.83
mmol/l
—
10
70
51
466
1.11
0.24
2.4
3.2
0.59
0.81
ug/l
1.25
33
306
23
199
1.16
0.24
1.2
1.3
—
27.26
—
0
13
5
38
1.32
0.23
1.4
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
6
48
1.25
0.20
1.2
1.2
6.87
6.80
mmol/l
—
6
40
25
222
1.13
0.19
2.0
2.4
—
21.40
—
0
13
68
639
1.08
0.19
3.0
4.5
26.28
21.10
%
1.52
20
314
39
425
0.91
0.19
3.9
4.4
31.79
32.84
%
0.22
28
286
13
111
1.18
0.16
1.2
1.9
—
—
—
0
0
11
95
1.16
0.11
2.4
3.3
20.18
26.23
u/ml
0.31
11
95
6
56
1.07
0.08
1.2
1.2
—
—
—
0
0
5
63
0.79
0.08
1.4
1.6
—
—
—
0
0
14
127
1.11
0.08
1.6
2.0
—
—
—
0
0
39
408
0.95
0.07
10.2
6.8
—
—
—
0
0
9
103
0.87
0.06
1.0
1.1
—
2.13
—
0
15
10
110
0.91
0.05
1.4
1.6
—
—
—
0
0
31
319
0.97
0.02
2.6
2.0
—
—
—
0
0
19
182
1.05
0.02
1.3
1.3
—
—
—
0
0
28
287
0.97
0.01
2.5
1.8
—
—
—
0
0
18
178
1.01
0.00
1.1
1.0
—
—
—
0
0
58
581
1.00
0.00
1.7
1.5
—
—
—
0
0
11
105
1.05
0.00
1.5
1.6
—
—
—
0
0
13
125
1.04
0.00
1.6
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
9
96
0.94
0.00
1.6
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYTHYSUBS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYTHYSUBS | 1.474 [1.22, 1.77] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 266 out of 1295 females with E4_HYTHYSUBS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYTHYSUBS | 1.706 [1.2, 2.43] | 0.003 |
| Birth year | 0.991 [0.98, 1.0] | 0.059 |
During the follow-up period (1.1.1998 — 31.12.2019), 125 out of 448 males with E4_HYTHYSUBS died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYTHYSUBS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.126% | 0.325% |
| 5 | 0.678% | 1.992% |
| 10 | 1.908% | 5.386% |
| 15 | 3.619% | 10.489% |
| 20 | 6.044% | 17.534% |
Relationships between endpoints
↥Index endpoint: E4_HYTHYSUBS – Hypothyroidism due to medicaments and other exogenous substances
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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