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Disorder of pancreatic internal secretion, other and/or unspecified

DOID EFO Endpoint Browser PheWeb

E4_PANCSECNAS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

262

4. Check minimum number of events

None

262

5. Include endpoints

None

262

6. Filter based on genotype QC (FinnGen only)

258

Control definitions (FinnGen only)

Control exclude
E4_GLUCOPANCREAS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1896 1059 820
Only index persons 1511 896 615
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 44.97 39.12 52.19
Only index persons 42.06 36.45 50.25

-FinnGen-

Key figures

All Female Male
Number of individuals 258 165 93
Unadjusted period prevalence (%) 0.05 0.06 0.04
Median age at first event (years) 41.78 35.67 52.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
262
Matched controls
2620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E16.9
ICD-10 Finland
Disorder of pancreatic internal secretion, unspecified
+∞
112.9
100
*
A09AA02
ATC
multienzymes (lipase, protease etc.); oral
40.6
105.4
67
22
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
67.4
103.8
58
11
A10AB05
ATC
insulin aspart; parenteral
13.2
81.9
95
108
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
19.6
80.6
69
47
T89
ICPC
Diabetes insulin dependent
18.4
77.1
68
49
A10AE04
ATC
insulin glargine; parenteral
11.6
76.6
99
130
25109
ICD-8 Finland
Disorders of pancreatic internal secretion other than diabetes mellitus, Unspecified
+∞
72.3
66
*
A10AB01
ATC
insulin (human); parenteral
19.7
70.5
59
38
A10AC01
ATC
insulin (human); parenteral
11.4
67.7
85
106
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
30.8
67.5
46
18
A10AA02, ,
ATC
19.1
65.0
55
36
103
Kela drug reimbursment
Diabetes, insulin-treated
8.0
64.3
161
434
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
19.5
61.5
51
32
A10AE05
ATC
insulin detemir; parenteral
11.9
58.7
68
75
215
Kela drug reimbursment
Diabetes, non-insulin-treated
7.2
57.9
146
389
H04AA01
ATC
glucagon; nasal, parenteral
23.2
56.7
43
22
A10AA01, ,
ATC
19.0
55.1
46
29
E16.89
ICD-10 Finland
Other specified disorders of pancreatic internal secretion
+∞
51.8
48
*
A10AB04
ATC
insulin lispro; parenteral
16.1
51.6
47
35
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
19.0
50.6
42
26
A10AE06
ATC
insulin degludec; parenteral
12.2
43.5
47
46
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
18.0
42.5
36
23
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
397.6
35.9
35
*
SPAT1262
SPAT
Handing over of treatment supplies
4.6
27.4
85
248
XCK10
NOMESCO Finland
Photography of fundus of eye
5.4
26.4
61
139
H3603, E103,
ICD-10 Finland
143.7
25.1
26
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.8
24.0
105
388
E16.19
ICD-10 Finland
Other specified hypoglycaemia
+∞
23.3
22
*
T90
ICPC
Diabetes non-insulin dependent
3.7
21.9
101
383
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
47.9
21.8
26
6
K90.3
ICD-10 Finland
Pancreatic steatorrhoea
75.6
19.0
21
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
15.1
18.8
31
23
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
19.6
16.8
25
14
A10BA02
ATC
metformin; oral
3.0
15.9
103
466
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.9
15.8
55
169
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
40.7
15.6
19
5
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
40.7
15.6
19
5
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
34.0
15.0
19
6
H3600, E103,
ICD-10 Finland
26.9
14.9
20
8
E16.0
ICD-10 Finland
Drug-induced hypoglycaemia without coma
+∞
14.7
14
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
14.4
61
213
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
13.8
14.2
24
19
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
13.7
104
505
2518X
ICD-9 Finland
Other disorders of pancreatic internal secretion, Other specified disorders of pancreatic internal secretion
+∞
13.7
13
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
5.0
13.5
31
69
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
42.4
13.3
16
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.8
13.0
25
47
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
73.5
12.7
14
*
B03BA03
ATC
hydroxocobalamin; parenteral
5.0
12.7
29
64
E16.85
ICD-10 Finland
Zollinger-Ellison syndrome
+∞
12.6
12
*
25108
ICD-8 Finland
Disorders of pancreatic internal secretion other than diabetes mellitus, Alia definita
+∞
12.6
12
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.7
12.6
31
73
K86.1
ICD-10 Finland
Other chronic pancreatitis
28.2
12.2
16
6
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.8
11.8
40
120
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
12.6
11.5
20
17
25009
ICD-8 Finland
Diabetes mellitus, Unspecified
36.8
11.4
14
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
18.1
11.4
17
10
B81
ICPC
Anaemia vit B12/folate deficiency
5.8
11.1
21
39
CKC12
NOMESCO Finland
Photocoagulation of retina
4.9
11.0
25
55
Y6099
ICD-8 Finland
Prenatal care and observation
4.1
10.8
32
87
177
Kela drug reimbursment
Insulin glargine 300 U / ml
10.7
10.7
20
20
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.9
10.5
58
234
2519X
ICD-9 Finland
Other disorders of pancreatic internal secretion, Unspecified disorder of pancreatic internal secretion
+∞
10.5
10
*
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.5
10.4
86
426
R4110
NOMESCO Finland
Physiotherapy
2.4
10.3
96
503
C03CA01
ATC
furosemide; systemic
2.4
10.2
93
481
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
8.2
10.1
22
29
Z3226
NOMESCO Finland
Physiotherapist
2.6
10.1
70
318
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.4
10.0
39
128
H3601, E103,
ICD-10 Finland
27.2
9.9
13
5
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
57.2
9.7
11
*
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
31.3
9.5
12
*
A10AD01
ATC
insulin (human); parenteral
9.2
9.5
19
22
E16.80
ICD-10 Finland
Hypergastrinaemia
+∞
9.4
9
*
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
5.3
9.2
19
38
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.6
9.2
32
97
TK800
NOMESCO Finland
Hemodialysis
10.6
9.2
17
17
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.0
9.1
27
73
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
9.1
74
361
ZXA00
NOMESCO Finland
Right side
2.3
9.0
89
473
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.8
9.0
21
47
D64.9
ICD-10 Finland
Anaemia, unspecified
3.3
8.9
37
126
TPH07
NOMESCO Finland
Cathetrisation of artery
3.1
8.9
41
149
Z2446
NOMESCO Finland
Social worker
3.4
8.8
34
111
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
51.8
8.7
10
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
8.7
56
244
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
17.0
8.6
13
8
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.7
8.5
53
227
RJ410, ,
NOMESCO Finland
92.9
8.5
9
*
E13.8
ICD-10 Finland
Other specified diabetes mellitus, with unspecified complications
+∞
8.4
8
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.5
8.4
21
50
ZXD05
NOMESCO Finland
Urgent procedure
2.2
8.3
93
518
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
8.3
64
304
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.3
8.2
22
55
EBA15
NOMESCO Finland
Extraction of multiple teeth
5.0
8.2
18
38
AA1AD
NOMESCO Finland
CT of head and brain
2.3
8.2
81
428
Z3231
NOMESCO Finland
Registered nurse
2.2
8.2
91
505
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.7
8.2
20
32
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
8.1
38
139
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
7.0
8.0
19
29
OAB50, ,
SPAT
3.9
7.9
24
66
A10BB12
ATC
glimepiride; oral
3.5
7.9
28
86
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
7.8
110
668
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
15.6
7.8
12
8
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
15.6
7.8
12
8
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
46.4
7.8
9
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.9
7.6
23
63
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
7.6
78
417
H43.1
ICD-10 Finland
Vitreous haemorrhage
8.0
7.5
16
21
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
3.7
7.5
24
69
E13
ICD-10 Finland
Other specified diabetes mellitus
82.3
7.5
8
*
C02AC05
ATC
moxonidine; oral
4.5
7.3
18
42
E16.10
ICD-10 Finland
Hyperinsulinism
+∞
7.3
7
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.6
7.3
25
75
Z3229
NOMESCO Finland
Other healthcare associate professional
3.0
7.3
35
130
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.9
7.3
36
136
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.9
7.2
17
26
Z94.0
ICD-10 Finland
Kidney transplant status
20.7
7.2
10
5
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.8
7.2
39
155
J01FF01
ATC
clindamycin; systemic
2.1
7.2
85
481
H36.00
ICD-10 Finland
Diabetic background retinopathy
9.2
7.1
14
16
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
7.0
6.9
16
24
A11CC03
ATC
alfacalcidol; systemic
8.6
6.9
14
17
205
Kela drug reimbursment
Chronic hypertension
2.2
6.9
76
417
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
6.9
48
216
Z2221
NOMESCO Finland
Medical doctor
2.1
6.8
86
496
WX002
NOMESCO Finland
Sedation and analgesia
2.3
6.8
62
314
H01CB02
ATC
octreotide; parenteral
41.1
6.8
8
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.0
6.7
19
50
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
10.4
6.6
12
12
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
6.6
111
710
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
6.6
81
463
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
6.5
125
834
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
6.5
102
635
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
6.5
79
449
RJ421, ,
NOMESCO Finland
71.5
6.5
7
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
14.8
6.4
10
7
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.5
6.3
43
191
WX730
NOMESCO Finland
Conventional respirator
18.6
6.3
9
5
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
27.4
6.3
8
*
K86.3
ICD-10 Finland
Pseudocyst of pancreas
27.4
6.3
8
*
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
27.4
6.3
8
*
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
6.2
161
1184
ZXE00
NOMESCO Finland
One hour or less
1.9
6.2
113
740
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.8
6.2
31
118
S97
ICPC
Chronic ulcer skin
3.2
6.1
25
84
A10AA03, ,
ATC
12.9
6.1
10
8
A10AB06
ATC
insulin glulisine; parenteral
12.9
6.1
10
8
RD210, ,
NOMESCO Finland
7.0
6.1
14
21
R06.0
ICD-10 Finland
Dyspnoea
2.0
6.1
80
466
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
10.4
6.1
11
11
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
6.1
88
531
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.8
6.1
31
119
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.1
6.0
25
85

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
55
66
10.28
44.14
2.0
1.4
156.60
304.19
ug/g
4.31
32
39
137
591
3.76
25.00
5.2
3.2
39.68
171.53
mg/l
0.65
105
381
141
632
3.67
24.02
5.2
3.2
6.76
7.50
mmol/l
1.01
125
536
139
625
3.61
23.42
6.3
3.8
7.80
9.15
mg/mmol
0.21
101
391
34
49
7.82
23.06
2.1
1.4
0.59
0.85
nmol/l
0.73
25
42
55
160
4.09
17.17
6.5
3.8
92.08
75.16
ng/l
0.84
46
146
60
204
3.52
14.81
1.8
1.8
426.44
362.52
nmol/l
1.60
54
190
152
881
2.73
14.15
7.6
4.6
34.04
36.11
g/l
4.20
143
832
68
274
3.00
12.52
3.8
2.3
22.03
22.69
%
0.13
61
235
93
465
2.55
11.13
1.7
1.5
23.82
21.34
nmol/l
0.92
74
389
159
1020
2.42
10.87
15.5
7.0
1.22
1.22
mmol/l
0.11
137
880
86
419
2.57
10.82
4.2
2.8
470.80
539.97
mosm/kgh2o
2.88
76
366
148
931
2.36
10.43
13.6
6.1
1.22
1.22
mmol/l
0.01
138
854
143
895
2.32
10.09
3.7
2.3
75.92
77.95
nmol/l
0.34
134
792
57
235
2.82
9.90
3.0
1.6
—
—
—
0
0
45
163
3.13
9.83
12.4
8.7
—
—
—
0
0
20
24
8.93
9.75
4.9
3.7
35.46
2.81
nmol/l
0.97
20
24
97
528
2.33
9.36
7.0
3.9
—
—
—
0
0
112
648
2.27
9.35
5.6
3.2
62.52
48.40
e6/l
0.12
93
495
90
480
2.33
9.06
3.4
2.1
2.90
3.11
mg/l
0.31
81
417
103
586
2.25
8.86
5.3
3.1
0.20
0.40
e6/l
1.25
83
437
85
448
2.33
8.75
4.0
2.6
10.23
4.78
e6/l
1.16
78
407
46
182
2.85
8.56
9.5
4.2
1.61
2.16
mmol/l
0.59
40
143
19
41
4.92
8.49
1.2
1.1
1.86
2.50
iu/ml
—
7
6
46
183
2.84
8.47
9.4
4.2
6.01
5.86
kpa
0.51
41
178
122
755
2.15
8.39
6.9
3.8
64.43
54.10
e6/l
0.16
94
533
128
809
2.14
8.32
3.0
1.9
91.68
97.02
pmol/l
0.40
68
394
117
721
2.13
8.06
3.4
3.3
2.36
2.36
mmol/l
0.06
102
631
110
666
2.12
7.90
3.9
2.4
47.18
63.10
u/l
1.39
101
608
139
925
2.07
7.69
11.9
12.2
1.19
1.22
inr
0.15
44
267
106
639
2.11
7.64
4.8
3.1
—
—
—
0
0
171
1231
2.12
7.62
11.2
4.9
8.53
6.57
mmol/l
10.37
166
1140
86
479
2.18
7.60
1.6
1.8
1.11
1.44
mg/l
0.45
68
374
105
635
2.09
7.47
7.7
3.7
7.39
7.40
ph
0.67
20
117
63
310
2.36
7.47
2.6
2.0
28.80
29.35
s
0.43
63
303
143
973
2.03
7.32
9.2
5.7
0.67
0.69
%
0.25
136
901
48
210
2.57
7.32
8.1
10.1
1.39
1.17
mmol/l
0.12
38
173
67
351
2.22
6.80
2.0
1.7
1165.18
1245.71
nmol/l
0.29
53
265
96
578
2.04
6.79
5.4
3.0
—
—
—
0
0
51
241
2.39
6.57
11.2
6.9
104.55
103.79
mmol/l
0.63
51
241
144
1011
1.94
6.45
9.9
6.0
8.71
8.48
%
0.48
137
943
146
1030
1.94
6.44
9.6
5.8
27.79
28.92
%
0.58
140
964
58
294
2.25
6.35
3.9
2.1
—
—
—
0
0
143
1007
1.92
6.29
9.5
5.7
3.05
2.80
%
0.66
136
935
62
328
2.17
6.09
5.2
3.0
3.31
2.80
e6/l
0.11
36
172
151
1090
1.91
6.09
8.9
5.7
1.93
2.04
e9/l
0.38
127
980
77
443
2.05
6.07
1.7
1.4
2.51
2.42
g/l
0.12
44
253
152
1102
1.90
6.02
9.5
5.9
0.22
0.18
e9/l
1.43
127
977
148
1066
1.89
5.96
8.9
5.7
0.04
0.04
e9/l
0.70
122
934
143
1021
1.88
5.90
9.6
5.6
57.18
56.47
%
0.28
137
961
84
504
1.98
5.87
1.7
1.3
1.00
1.15
u/ml
0.14
21
140
141
1006
1.87
5.79
9.1
6.3
—
—
—
0
0
166
1248
1.90
5.78
13.8
9.0
4.12
3.95
e9/l
0.48
139
1099
55
283
2.19
5.77
2.6
2.3
178.17
109.79
ug/g
0.70
46
227
147
1065
1.87
5.73
8.9
5.7
0.61
0.56
e9/l
1.83
122
930
9
7
13.25
5.62
3.9
4.6
17.67
29.29
umol/l
—
9
7
152
1126
1.83
5.39
8.0
5.9
9.02
11.10
umol/l
3.27
145
1059
34
149
2.47
5.13
2.2
2.7
65.83
69.05
e9/l
0.33
23
111
184
1458
1.88
5.13
7.3
4.2
—
—
—
0
0
125
886
1.79
5.02
4.4
2.7
113.35
107.40
ug/l
0.16
120
815
11
16
7.12
5.00
4.1
2.4
—
—
—
0
0
65
381
1.94
4.75
4.8
3.5
133.31
300.11
ng/l
0.63
45
291
85
548
1.82
4.61
10.4
7.0
—
—
—
0
0
15
36
4.36
4.59
3.5
3.8
—
—
—
0
0
93
617
1.79
4.58
3.1
2.2
158.85
212.67
u/l
0.53
85
584
43
220
2.14
4.54
3.0
2.2
20.91
28.58
u/l
1.45
34
185
64
383
1.89
4.37
2.8
2.8
2.47
2.45
mmol/l
0.63
54
335
46
246
2.06
4.33
3.1
2.8
5.68
6.09
umol/l
0.12
41
217
52
296
1.94
4.11
1.5
1.2
—
—
—
0
0
14
42
3.47
4.10
5.8
2.5
—
—
—
0
0
10
19
5.43
3.86
2.7
2.4
—
—
—
0
0
9
15
6.17
3.85
3.2
4.1
10.37
59.25
mu/l
—
9
15
65
406
1.80
3.84
1.8
1.8
473.22
455.14
pmol/l
0.20
55
343
42
227
2.01
3.83
2.0
1.5
—
—
—
0
0
92
636
1.69
3.80
3.8
2.2
—
—
—
0
0
11
24
4.74
3.79
1.2
1.1
—
—
—
0
0
129
975
1.64
3.75
15.6
8.9
0.00
0.00
e9/l
1.15
99
803
44
245
1.96
3.69
1.3
1.3
—
—
—
0
0
23
99
2.45
3.62
7.7
14.4
—
—
—
0
0
17
63
2.82
3.56
1.6
1.2
—
—
—
0
0
6
6
10.19
3.51
1.0
1.0
1507.83
1739.50
miu/ml
—
6
6
78
526
1.69
3.49
3.6
2.6
3841.49
6910.59
umol/l
0.34
72
454
84
584
1.65
3.33
2.0
1.6
1.34
1.41
mmol/l
0.34
73
489
16
60
2.78
3.29
3.9
2.5
—
—
—
0
0
194
1652
1.67
3.28
12.3
7.0
90.01
78.02
u/l
2.14
189
1536
29
146
2.11
3.20
1.4
1.5
—
—
—
0
0
13
40
3.37
3.19
2.2
1.4
—
—
—
0
0
25
119
2.22
3.16
4.5
2.4
—
—
—
0
0
13
45
2.99
3.07
2.8
2.8
—
—
—
0
0
6
8
7.64
3.07
2.3
13.4
—
—
—
0
0
8
17
4.82
2.94
1.0
1.1
—
—
—
0
0
5
6
8.46
2.76
3.4
1.5
—
—
—
0
0
8
19
4.31
2.70
1.3
1.3
—
—
—
0
0
173
1465
1.53
2.69
4.7
3.8
—
—
—
0
0
33
186
1.89
2.68
1.4
1.4
—
—
—
0
0
24
122
2.06
2.60
8.1
8.2
—
—
—
0
0
111
869
1.48
2.47
4.0
3.4
5.33
5.89
ph
—
6
65
11
40
2.83
2.30
1.7
1.5
324.00
268.15
u/ml
—
5
20
8
23
3.55
2.29
1.4
1.3
—
—
—
0
0
18
86
2.17
2.29
3.4
1.7
—
—
—
0
0
9
29
3.18
2.24
1.3
1.6
—
—
—
0
0
131
1073
1.44
2.24
5.1
3.6
0.00
0.02
estimate
0.50
24
196
130
1064
1.44
2.23
7.3
4.8
0.00
0.00
estimate
-0.00
31
203
45
294
1.64
2.23
1.9
1.6
—
—
—
0
0
129
1059
1.43
2.16
5.1
3.6
0.00
0.00
estimate
-0.00
31
216
14
62
2.33
2.11
3.2
1.6
461.14
288.38
mu/l
0.54
14
56
31
187
1.75
2.05
7.6
4.1
—
—
—
0
0
6
15
4.07
2.05
2.0
2.5
—
—
—
0
0
8
26
3.14
2.03
1.0
1.5
—
—
—
0
0
50
344
1.56
2.01
2.2
1.7
—
—
—
0
0
19
99
1.99
1.96
20.5
4.1
—
—
—
0
0
8
27
3.02
1.95
1.0
1.5
—
—
—
0
0
9
33
2.79
1.95
3.3
1.5
—
—
—
0
0
5
11
4.61
1.95
1.0
1.5
—
—
—
0
0
217
1984
1.55
1.91
12.2
5.6
51.14
39.60
mmol/mol
18.44
205
1851
6
17
3.59
1.85
1.5
3.2
47.88
16.99
ug/l
—
6
17
7
23
3.10
1.81
1.4
1.3
—
—
—
0
0
0
46
0.00
1.72
0.0
1.5
—
—
—
0
0
5
13
3.90
1.72
1.4
1.2
2.08
1.82
mmol/l
—
5
13
21
120
1.82
1.68
13.3
9.0
1.75
1.41
%
0.53
21
120
11
221
0.48
1.65
1.0
1.4
—
—
—
0
0
10
44
2.32
1.57
1.3
1.2
4.83
3.72
mmol/l
—
10
38
74
580
1.38
1.53
4.7
3.1
—
—
—
0
0
0
45
0.00
1.51
0.0
1.4
—
—
—
0
0
0
45
0.00
1.51
0.0
1.4
—
—
—
0
0
18
102
1.82
1.49
1.1
1.1
—
—
—
0
0
21
125
1.74
1.49
1.5
1.3
—
—
—
0
0
95
778
1.35
1.48
5.0
3.6
30.22
39.42
ng/l
0.55
75
521
193
2082
0.72
1.46
6.7
4.5
7.12
5.92
mmol/l
8.54
174
1913
65
504
1.39
1.42
4.1
3.6
—
—
—
0
0
10
46
2.22
1.41
3.2
2.6
300.82
9192.55
u/l
—
5
18
19
112
1.75
1.39
2.5
2.3
—
—
—
0
0
20
120
1.72
1.38
13.7
9.0
0.71
0.71
%
0.01
20
120
23
144
1.65
1.37
3.1
2.4
4.68
5.92
e9/l
0.31
18
120
5
17
2.98
1.36
4.4
1.9
40.46
35.52
%
—
5
17
5
17
2.98
1.36
1.4
1.1
—
—
—
0
0
5
17
2.98
1.36
1.0
1.1
—
—
—
0
0
13
68
1.96
1.36
1.8
1.5
—
—
—
0
0
214
1990
1.41
1.35
7.4
4.8
1.96
1.94
mu/l
0.06
201
1823
9
43
2.13
1.31
3.9
5.2
—
—
—
0
0
27
179
1.57
1.30
1.3
1.2
—
—
—
0
0
24
156
1.59
1.25
2.0
2.6
—
20.70
—
0
8
8
36
2.26
1.25
1.1
1.2
—
—
—
0
0
24
158
1.57
1.19
3.1
4.5
0.00
0.39
%
—
9
50
8
38
2.14
1.19
3.0
1.3
—
—
—
0
0
13
72
1.85
1.17
2.5
3.2
—
—
—
0
0
5
20
2.53
1.15
1.8
1.6
—
—
—
0
0
35
253
1.44
1.14
1.9
1.5
—
—
—
0
0
27
185
1.51
1.14
5.7
3.5
—
—
—
0
0
74
606
1.31
1.13
5.8
3.7
—
—
—
0
0
10
51
2.00
1.12
1.3
1.3
625.10
435.96
mg/l
—
10
46
5
21
2.41
1.09
4.6
1.3
87.10
90.56
%
—
5
21
5
21
2.41
1.09
1.8
1.7
29.20
33.05
pg
—
5
21
7
32
2.22
1.09
1.0
1.0
—
—
—
0
0
23
155
1.53
1.05
1.1
1.2
148.79
158.42
iu/ml
—
8
62
5
22
2.30
1.04
2.0
1.9
—
—
—
0
0
175
1607
1.27
1.02
6.1
4.1
15.66
11.37
mm/h
2.68
164
1460
159
1444
1.26
1.02
5.1
3.0
72.28
44.83
u/l
2.02
147
1348
13
76
1.75
1.01
1.8
1.5
—
—
—
0
0
24
166
1.49
0.98
3.1
4.5
0.11
0.18
%
—
9
51
7
36
1.97
0.98
2.7
1.8
—
—
—
0
0
13
78
1.70
0.93
1.4
1.2
—
—
—
0
0
180
1669
1.25
0.91
6.1
4.0
14.98
14.72
pmol/l
0.67
170
1513
20
136
1.51
0.89
3.6
2.7
—
—
—
0
0
25
179
1.44
0.88
3.0
4.4
0.44
0.73
%
—
9
64
8
46
1.76
0.83
1.5
1.4
2.63
219.97
e6/l
—
8
36
8
46
1.76
0.83
1.4
1.3
67.37
3.68
e6/l
—
8
34
22
157
1.44
0.79
3.3
4.6
0.00
0.02
%
—
8
43
6
33
1.84
0.79
6.3
3.0
—
—
—
0
0
214
2039
1.27
0.76
5.2
4.0
1.36
1.28
mmol/l
0.46
195
1881
22
159
1.42
0.75
1.5
1.4
—
—
—
0
0
7
38
1.86
0.74
2.4
3.2
59.00
61.21
%
—
7
38
5
26
1.94
0.71
1.2
3.3
—
—
—
0
0
225
2162
1.29
0.70
30.0
13.1
24.96
21.82
mg/l
0.79
194
1661
7
41
1.73
0.70
1.0
1.4
—
—
—
0
0
57
480
1.24
0.70
4.2
3.9
1.02
1.02
kg/l
0.47
12
60
5
27
1.87
0.69
1.0
1.0
—
—
—
0
0
33
260
1.31
0.68
1.2
1.3
—
—
—
0
0
14
95
1.50
0.65
1.4
1.2
—
—
—
0
0
234
2401
0.76
0.61
43.6
19.4
129.39
135.62
g/l
7.72
234
2361
44
367
1.24
0.59
1.2
1.3
35.64
26.38
iu/ml
0.27
14
119
234
2399
0.77
0.58
43.2
19.4
4.37
4.50
e12/l
3.13
228
2330
234
2399
0.77
0.58
43.1
19.3
29.96
30.26
pg
1.75
234
2360
70
792
0.84
0.58
3.5
2.8
—
—
—
0
0
234
2398
0.77
0.57
43.1
19.3
90.65
90.92
fl
0.39
234
2359
234
2398
0.77
0.57
43.1
19.4
7.24
6.66
e9/l
3.84
228
2332
15
205
0.72
0.57
1.3
1.3
—
—
—
0
0
6
38
1.59
0.54
6.7
3.3
—
—
—
0
0
6
38
1.59
0.54
2.5
2.7
4.84
4.96
e9/l
—
6
38
234
2396
0.78
0.53
43.0
19.4
38.29
40.27
%
4.04
226
2260
24
188
1.30
0.53
1.5
1.5
—
—
—
0
0
12
84
1.45
0.50
1.2
1.1
—
—
—
0
0
5
81
0.61
0.46
1.0
1.1
—
—
—
0
0
223
2164
1.20
0.46
6.9
4.9
2.34
2.80
mmol/l
12.26
209
1999
7
49
1.44
0.46
4.6
3.6
15.43
31.02
u/ml
—
7
49
7
50
1.41
0.45
2.1
1.1
—
—
—
0
0
14
105
1.35
0.42
3.4
3.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
8
61
1.32
0.40
2.1
4.3
—
—
—
0
0
93
858
1.13
0.39
2.3
2.1
—
—
—
0
0
13
98
1.34
0.38
2.0
1.9
—
—
—
0
0
5
37
1.36
0.37
1.6
1.4
—
—
—
0
0
5
37
1.36
0.37
1.0
1.1
—
—
—
0
0
5
37
1.36
0.37
1.0
1.1
—
—
—
0
0
53
591
0.87
0.36
1.5
1.5
—
—
—
0
0
6
46
1.31
0.33
2.3
1.6
—
—
—
0
0
7
54
1.30
0.30
3.0
2.6
—
—
—
0
0
216
2114
1.12
0.26
6.0
4.4
1.43
1.50
mmol/l
1.78
200
1957
26
298
0.86
0.26
2.7
2.7
0.59
0.72
ug/l
0.50
20
180
63
585
1.10
0.24
5.4
3.8
0.00
0.00
estimate
-0.00
30
200
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
15870.00
—
0
7
0
14
0.00
0.20
0.0
1.3
—
2502.67
—
0
9
6
53
1.14
0.19
1.7
1.3
—
—
—
0
0
180
1840
0.93
0.18
39.0
17.2
329.67
332.30
g/l
2.94
180
1829
7
62
1.13
0.17
16.6
3.1
3.86
3.97
mmol/l
—
7
62
7
62
1.13
0.17
1.6
1.4
—
—
—
0
0
7
62
1.13
0.17
1.6
1.4
—
—
—
0
0
7
63
1.11
0.17
1.6
1.4
—
—
—
0
0
5
68
0.73
0.17
1.2
1.4
—
2.00
—
0
5
6
76
0.78
0.16
16.5
9.5
—
—
—
0
0
227
2242
1.09
0.15
27.8
12.2
—
—
—
0
0
9
82
1.10
0.15
19.6
3.7
—
—
—
0
0
16
180
0.88
0.13
1.9
1.6
—
—
—
0
0
215
2126
1.06
0.11
6.0
4.5
4.23
4.73
mmol/l
10.03
199
1975
6
57
1.05
0.08
1.2
1.4
—
2.32
—
0
12
7
64
1.10
0.08
1.6
1.4
—
—
—
0
0
7
64
1.10
0.08
1.6
1.4
—
—
—
0
0
230
2287
1.05
0.05
17.7
10.1
27.11
26.24
u/l
0.31
225
2194
23
221
1.04
0.03
1.9
1.7
—
—
—
0
0
12
121
0.99
0.00
1.2
1.3
—
—
—
0
0
36
361
1.00
0.00
1.3
1.3
34.77
8.66
u/ml
0.75
15
142
19
186
1.02
0.00
5.5
3.4
—
—
—
0
0
0
8
0.00
0.00
0.0
5.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
-0.00
1.2
1.8
23.20
12.54
mg/l
—
5
54
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
14.68
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.6
—
5.18
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
34.92
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_PANCSECNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PANCSECNAS 2.933 [2.09, 4.12] < 0.001
Birth year 0.991 [0.98, 1.0] 0.055

During the follow-up period (1.1.1998 — 31.12.2019), 166 out of 473 females with E4_PANCSECNAS died.

Males

Parameter HR [95% CI] p-value
E4_PANCSECNAS 4.546 [3.15, 6.57] < 0.001
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 479 males with E4_PANCSECNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_PANCSECNAS.

N-year risk Females Males
1 0.191% 0.945%
5 1.541% 5.339%
10 4.135% 12.739%
15 7.215% 22.267%
20 12.337% 36.003%

Relationships between endpoints

↥

Index endpoint: E4_PANCSECNAS – Disorder of pancreatic internal secretion, other and/or unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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