Disorder of pancreatic internal secretion, other and/or unspecified

E4_PANCSECNAS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

254

4. Check minimum number of events

None

254

5. Include endpoints

None

254

6. Filter based on genotype QC (FinnGen only)

254

Control definitions (FinnGen only)

Control exclude
E4_GLUCOPANCREAS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1896 1059 820
Only index persons 1511 896 615
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 44.97 39.12 52.19
Only index persons 42.06 36.45 50.25

-FinnGen-

Key figures

All Female Male
Number of individuals 254 161 93
Unadjusted period prevalence (%) 0.05 0.05 0.04
Median age at first event (years) 41.43 34.97 52.62

-FinRegistry-

Age distribution of first events

0102030405060708090020406080100120140160180200220240260280300AgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080051015202530354045AgeIndividuals

-FinRegistry-

Year distribution of first events

19751980198519901995200020052010201520202022020406080100120140160180200220240260YearIndividuals

-FinnGen-

Year distribution of first events

19701975198019851990199520002005201020152020202305101520253035YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
232
Matched controls
2319
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E16.9
ICD-10 Finland
Disorder of pancreatic internal secretion, unspecified
+∞
98.0
87
*
25109
ICD-8 Finland
Disorders of pancreatic internal secretion other than diabetes mellitus, Unspecified
+∞
63.5
58
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
17.5
49.5
82
70
A10AE04
ATC
insulin glargine; parenteral
13.4
46.1
87
99
A09AA02
ATC
multienzymes (lipase, protease etc.)
47.5
45.7
55
15
103
Kela drug reimbursment
Diabetes, insulin-treated
7.7
44.4
139
375
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
15.6
44.0
76
70
E16.89
ICD-10 Finland
Other specified disorders of pancreatic internal secretion
+∞
43.1
40
*
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
61.7
42.7
49
10
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
21.7
42.1
63
39
T89
ICPC
Diabetes insulin dependent
28.6
41.8
57
26
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
30.9
41.2
55
23
A10AA02
ATC
NA
27.6
37.8
52
24
215
Kela drug reimbursment
Diabetes, non-insulin-treated
6.6
37.0
124
342
A10AE05
ATC
insulin detemir; parenteral
15.9
36.7
62
52
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
33.4
35.4
46
17
A10AA01
ATC
NA
29.0
31.9
43
18
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
29.0
30.5
41
17
H04AA01
ATC
glucagon; nasal, parenteral
28.1
28.1
38
16
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
26.4
27.6
38
17
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
110.0
27.3
29
*
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
18.7
27.2
42
27
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
34.7
25.8
33
11
A10AE06
ATC
insulin degludec; parenteral
21.8
25.3
37
20
H3603, E103
ICD-10 Finland
NA
44.3
19.9
24
6
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
34.8
19.7
25
8
E10
ICD-10 Finland
Type 1 diabetes mellitus
21.0
19.2
28
15
E16.19
ICD-10 Finland
Other specified hypoglycaemia
+∞
19.0
18
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.1
18.8
89
304
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
46.0
17.6
21
5
SPAT1262
SPAT
Handing over of treatment supplies
4.2
17.6
77
243
T90
ICPC
Diabetes non-insulin dependent
3.9
16.5
82
287
XCK10
NOMESCO Finland
Photography of fundus of eye
5.4
16.5
53
120
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
38.8
14.7
18
5
H3600, E103
ICD-10 Finland
NA
24.2
14.5
20
9
K90.3
ICD-10 Finland
Pancreatic steatorrhoea
45.7
14.3
17
*
2518X
ICD-9 Finland
Other disorders of pancreatic internal secretion, Other specified disorders of pancreatic internal secretion
+∞
13.7
13
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
30.4
13.2
17
6
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
30.4
13.2
17
6
E16.85
ICD-10 Finland
Zollinger-Ellison syndrome
+∞
12.6
12
*
A10BA02
ATC
metformin; oral
3.1
12.6
88
384
25108
ICD-8 Finland
Disorders of pancreatic internal secretion other than diabetes mellitus, Alia definita
+∞
11.6
11
*
E16.0
ICD-10 Finland
Drug-induced hypoglycaemia without coma
+∞
11.6
11
*
H3601, E103
ICD-10 Finland
NA
126.0
11.5
12
*
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
14.9
11.2
18
13
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
10.9
51
164
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
7.2
10.9
26
40
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
29.6
10.9
14
5
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
13.8
10.8
18
14
2519X
ICD-9 Finland
Other disorders of pancreatic internal secretion, Unspecified disorder of pancreatic internal secretion
+∞
10.5
10
*
25009
ICD-8 Finland
Diabetes mellitus, Unspecified
42.0
10.1
12
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
27.4
9.9
13
5
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
9.6
49
168
E16.80
ICD-10 Finland
Hypergastrinaemia
+∞
9.4
9
*
177
Kela drug reimbursment
Insulin glargine 300 U / ml
12.2
9.2
16
14
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
38.3
9.1
11
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
25.2
9.0
12
5
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
13.3
9.0
15
12
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
9.2
9.0
18
21
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
52.0
8.7
10
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.5
8.7
22
37
ZXA00
NOMESCO Finland
Right side
2.5
8.5
79
395
K86.1
ICD-10 Finland
Other chronic pancreatitis
13.4
8.5
14
11
RJ410
NOMESCO Finland
NA
93.3
8.5
9
*
RJ420
NOMESCO Finland
NA
93.3
8.5
9
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
9.1
8.5
17
20
B81
ICPC
Anaemia vit B12/folate deficiency
9.1
8.5
17
20
TK800
NOMESCO Finland
Hemodialysis
11.4
8.4
15
14
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.5
8.4
78
389
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
+∞
8.4
8
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
8.4
80
406
C03CA01
ATC
furosemide; systemic
2.5
8.2
73
357
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
34.7
8.1
10
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.0
8.1
49
189
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
23.0
8.1
11
5
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.8
8.1
22
41
CKC10
NOMESCO Finland
Local photocoagulation of retina
13.7
8.0
13
10
CKC12
NOMESCO Finland
Photocoagulation of retina
5.7
7.9
22
42
B03BA03
ATC
hydroxocobalamin; parenteral
6.0
7.9
21
38
Y6099
ICD-8 Finland
Prenatal care and observation
4.7
7.8
26
61
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
15.7
7.8
12
8
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.3
7.7
15
17
R4110
NOMESCO Finland
Physiotherapy
2.4
7.6
77
400
E13.8
ICD-10 Finland
Other specified diabetes mellitus, with unspecified complications
+∞
7.3
7
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
7.3
52
222
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
7.7
7.3
16
22
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.7
7.2
31
93
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.8
7.2
23
52
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
20.8
7.2
10
5
A10AA03
ATC
NA
20.8
7.2
10
5
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.3
7.2
21
43
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
5.5
7.1
20
39
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
7.0
60
283
A10BB12
ATC
glimepiride; oral
4.3
7.0
25
63
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.9
7.0
46
185
H3601, E113
ICD-10 Finland
NA
14.4
7.0
11
8
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
6.9
107
664
H36.01
ICD-10 Finland
Diabetic maculopathy
41.3
6.8
8
*
E13
ICD-10 Finland
Other specified diabetes mellitus
41.3
6.8
8
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.0
6.7
26
71
6480A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Diabetes mellitus
23.3
6.7
9
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
12.8
6.6
11
9
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
7.8
6.5
14
19
RJ421
NOMESCO Finland
NA
71.7
6.5
7
*
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
71.7
6.5
7
*
A12AA04
ATC
calcium carbonate; oral
14.8
6.5
10
7
TPH07
NOMESCO Finland
Cathetrisation of artery
3.2
6.4
33
115
WX002
NOMESCO Finland
Sedation and analgesia
2.4
6.4
56
268
127
Kela drug reimbursment
Transplant complication
18.6
6.3
9
5
E16.10
ICD-10 Finland
Hyperinsulinism
+∞
6.3
6
*
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
6.1
6.3
16
28
Z94.0
ICD-10 Finland
Kidney transplant status
27.5
6.3
8
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
27.5
6.3
8
*
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
3.4
6.3
29
93
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.0
6.2
35
129
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
6.2
61
309
NHQ40
NOMESCO Finland
Amputation of toe
13.0
6.1
10
8
L04AA06
ATC
mycophenolic acid; systemic
13.0
6.1
10
8
H43.1
ICD-10 Finland
Vitreous haemorrhage
7.0
6.1
14
21
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
9.0
6.1
12
14
205
Kela drug reimbursment
Chronic hypertension
2.2
6.1
68
361
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
10.4
6.1
11
11

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
65
9.33
37.54
2.0
1.4
159.91
303.69
ug/g
3.63
27
38
133
569
3.81
24.70
5.3
3.2
38.64
173.57
mg/l
0.63
100
364
136
607
3.67
23.35
5.3
3.2
6.81
7.61
mmol/l
1.10
120
510
134
601
3.60
22.67
6.6
3.9
7.44
8.49
mg/mmol
0.16
96
374
31
49
7.07
19.31
2.2
1.4
0.61
0.85
nmol/l
0.60
23
42
53
156
4.03
16.28
6.6
3.8
94.29
74.32
ng/l
1.02
44
142
19
24
8.48
14.21
5.2
3.7
37.26
2.81
nmol/l
0.97
19
24
147
850
2.73
13.78
7.7
4.6
33.97
36.10
g/l
4.21
139
803
57
198
3.42
13.57
1.9
1.9
436.82
365.51
nmol/l
1.84
51
184
67
263
3.10
13.01
3.9
2.3
21.85
22.66
%
0.16
60
226
56
223
2.94
10.43
3.0
1.6
—
—
—
0
0
89
450
2.51
10.35
1.7
1.5
23.20
21.54
nmol/l
0.55
70
377
144
903
2.37
10.30
13.9
6.2
1.22
1.22
mmol/l
0.01
134
824
81
396
2.53
10.08
4.2
2.7
466.06
546.57
mosm/kgh2o
3.46
71
344
152
986
2.35
9.91
16.0
7.0
1.22
1.22
mmol/l
0.06
129
842
44
158
3.16
9.77
12.7
8.8
—
—
—
0
0
88
463
2.38
9.21
3.4
2.1
2.95
3.12
mg/l
0.23
79
402
113
669
2.24
8.89
9.0
5.6
—
—
—
0
0
93
511
2.29
8.73
7.3
3.9
—
—
—
0
0
107
624
2.23
8.69
5.7
3.2
62.44
49.19
e6/l
0.11
89
477
45
175
2.91
8.67
9.4
4.4
—
—
—
0
0
99
562
2.25
8.57
5.3
3.0
0.20
0.39
e6/l
1.02
79
419
82
431
2.33
8.51
4.1
2.5
10.33
4.66
e6/l
1.12
73
385
115
698
2.18
8.39
3.5
3.3
2.36
2.36
mmol/l
0.01
100
604
44
175
2.83
8.12
9.7
4.2
1.68
2.18
mmol/l
0.48
37
134
44
176
2.81
8.03
9.6
4.2
6.00
5.85
kpa
0.45
39
171
62
301
2.40
7.61
2.6
2.0
28.76
29.42
s
0.53
62
294
166
1192
2.13
7.51
11.4
4.9
8.49
6.56
mmol/l
9.77
160
1102
116
730
2.08
7.49
7.0
3.7
67.14
52.90
e6/l
0.22
90
514
122
784
2.07
7.43
3.1
1.9
91.96
97.14
pmol/l
0.37
65
383
101
605
2.11
7.42
4.9
3.0
—
—
—
0
0
102
614
2.10
7.39
7.9
3.8
7.39
7.40
ph
0.49
19
111
119
759
2.07
7.38
7.8
8.6
1.19
1.19
inr
0.02
35
215
83
463
2.18
7.31
1.6
1.8
1.12
1.42
mg/l
0.39
67
360
11
16
7.14
7.21
4.1
2.4
—
—
—
0
0
105
646
2.07
7.12
4.0
2.4
46.75
56.50
u/l
2.03
96
588
94
555
2.10
7.12
5.5
2.9
—
—
—
0
0
138
938
2.03
7.10
9.4
5.6
0.67
0.69
%
0.19
131
870
46
204
2.53
6.82
8.4
10.3
1.48
1.20
mmol/l
0.15
37
166
65
339
2.23
6.69
2.0
1.7
1139.20
1244.10
nmol/l
0.41
51
258
17
41
4.37
6.66
1.2
1.1
1.17
2.50
iu/ml
—
6
6
57
283
2.31
6.59
3.9
2.1
—
—
—
0
0
138
965
1.94
6.27
9.7
5.6
3.13
2.75
%
1.24
131
894
138
969
1.93
6.15
10.2
6.0
8.72
8.52
%
0.41
131
906
140
988
1.93
6.14
9.8
5.8
27.35
28.89
%
0.90
134
919
48
230
2.34
5.99
11.8
7.0
104.35
103.63
mmol/l
0.56
48
223
15
36
4.37
5.91
3.5
4.0
—
—
—
0
0
34
140
2.65
5.83
2.2
2.7
65.83
70.20
e9/l
0.48
23
105
59
312
2.16
5.81
5.2
3.0
3.35
2.80
e6/l
0.11
34
164
145
1049
1.89
5.76
9.2
5.7
1.91
2.06
e9/l
0.47
122
936
146
1062
1.88
5.67
9.7
5.9
0.23
0.19
e9/l
1.61
122
941
142
1024
1.88
5.67
9.1
5.6
0.61
0.56
e9/l
1.61
118
891
9
7
13.27
5.62
3.9
4.6
17.67
29.29
umol/l
—
9
7
142
1027
1.87
5.58
9.1
5.7
0.04
0.04
e9/l
0.72
118
898
137
981
1.86
5.55
9.9
5.5
57.33
56.52
%
0.32
132
923
160
1209
1.87
5.40
14.2
9.0
4.12
3.96
e9/l
0.43
135
1064
10
19
5.44
5.08
2.8
2.5
—
—
—
0
0
178
1410
1.88
4.97
7.4
4.2
—
—
—
0
0
84
532
1.87
4.90
10.5
7.0
—
—
—
0
0
121
857
1.79
4.88
4.4
2.7
114.30
107.13
ug/l
0.19
116
789
11
24
4.75
4.83
1.2
1.1
—
—
—
0
0
71
429
1.91
4.77
1.7
1.4
2.55
2.43
g/l
0.16
40
246
145
1093
1.76
4.64
8.2
5.9
9.12
11.17
umol/l
3.01
138
1029
63
369
1.94
4.63
5.0
3.5
136.20
308.66
ng/l
0.64
44
282
62
363
1.94
4.55
2.8
2.8
2.47
2.45
mmol/l
0.74
52
315
51
279
2.04
4.54
2.6
2.3
191.05
109.50
ug/g
0.80
42
222
78
494
1.84
4.50
1.8
1.3
1.02
1.16
u/ml
0.11
20
139
45
237
2.09
4.42
3.1
2.8
5.72
6.19
umol/l
0.14
40
209
42
218
2.11
4.28
2.0
1.5
—
—
—
0
0
64
389
1.86
4.17
1.8
1.8
466.65
455.38
pmol/l
0.11
54
330
89
598
1.75
4.16
3.2
2.2
162.33
215.45
u/l
0.49
81
565
41
216
2.07
4.02
3.0
2.2
20.91
28.72
u/l
1.49
34
181
17
60
2.96
3.87
1.6
1.2
—
—
—
0
0
9
15
6.18
3.85
3.2
4.1
10.37
59.25
mu/l
—
9
15
13
39
3.46
3.81
6.2
2.6
—
—
—
0
0
13
39
3.46
3.81
2.2
1.4
—
—
—
0
0
33
163
2.18
3.81
9.0
7.5
1.35
1.42
mmol/l
0.17
33
158
23
97
2.51
3.77
7.7
14.5
—
—
—
0
0
90
621
1.70
3.76
3.9
2.2
—
—
—
0
0
43
237
1.98
3.73
1.3
1.3
—
—
—
0
0
83
562
1.71
3.71
2.0
1.7
1.34
1.41
mmol/l
0.32
72
469
25
111
2.39
3.69
4.5
2.5
—
—
—
0
0
29
138
2.24
3.66
1.4
1.5
—
—
—
0
0
124
939
1.63
3.57
15.9
8.8
0.00
0.00
e9/l
0.98
95
772
6
6
10.20
3.51
1.0
1.0
1507.83
1739.50
miu/ml
—
6
6
6
6
10.20
3.51
2.3
9.3
—
—
—
0
0
41
227
1.96
3.51
12.7
18.4
0.98
1.27
inr
—
5
35
16
60
2.78
3.29
4.1
2.6
—
—
—
0
0
48
287
1.83
3.26
1.5
1.2
—
—
—
0
0
8
15
5.47
3.21
1.0
1.1
—
—
—
0
0
74
506
1.65
3.12
3.7
2.7
4167.12
7181.01
umol/l
0.31
66
436
12
40
3.10
3.01
2.9
3.0
—
—
—
0
0
186
1603
1.60
2.77
12.6
7.0
90.72
78.28
u/l
2.14
181
1488
5
6
8.47
2.76
3.4
1.5
—
—
—
0
0
8
19
4.31
2.70
1.3
1.3
—
—
—
0
0
45
281
1.73
2.64
1.9
1.6
—
—
—
0
0
11
38
2.98
2.61
1.7
1.5
324.00
268.15
u/ml
—
5
20
167
1415
1.53
2.59
4.7
3.7
—
—
—
0
0
32
181
1.88
2.58
1.4
1.4
—
—
—
0
0
23
120
2.01
2.34
8.3
8.3
—
—
—
0
0
50
332
1.63
2.33
2.2
1.7
—
—
—
0
0
9
28
3.29
2.33
1.3
1.6
—
—
—
0
0
8
23
3.56
2.29
1.4
1.3
—
—
—
0
0
126
1034
1.43
2.13
5.1
3.6
0.00
0.02
estimate
0.50
23
188
125
1025
1.43
2.12
7.2
4.8
0.00
0.00
estimate
0.00
29
193
8
25
3.27
2.11
1.0
1.5
—
—
—
0
0
17
83
2.12
2.06
3.6
1.7
—
—
—
0
0
124
1019
1.42
2.06
5.0
3.6
0.00
0.00
estimate
0.00
25
194
6
15
4.07
2.05
3.0
2.7
27.29
24.06
mg/l
—
6
10
6
15
4.07
2.05
2.0
2.5
—
—
—
0
0
8
26
3.14
2.03
2.8
3.7
13.95
14.68
umol/l
—
8
18
8
26
3.14
2.03
1.0
1.5
—
—
—
0
0
5
11
4.61
1.95
1.0
1.5
—
—
—
0
0
7
22
3.24
1.89
1.4
1.4
—
—
—
0
0
21
116
1.88
1.85
13.3
9.1
1.75
1.43
%
0.49
21
116
5
12
4.23
1.83
1.4
1.2
2.08
1.80
mmol/l
—
5
12
29
179
1.70
1.79
7.8
4.2
—
—
—
0
0
209
1913
1.52
1.79
12.3
5.6
51.07
39.57
mmol/mol
17.74
198
1787
13
61
2.19
1.74
3.4
1.6
469.92
291.11
mu/l
0.51
13
55
18
97
1.92
1.71
21.4
4.1
—
—
—
0
0
8
32
2.55
1.61
3.6
1.5
—
—
—
0
0
7
26
2.74
1.59
3.7
1.8
—
—
—
0
0
7
26
2.74
1.59
3.7
1.8
—
—
—
0
0
7
26
2.74
1.59
3.7
1.8
—
—
—
0
0
7
26
2.74
1.59
3.7
1.8
—
—
—
0
0
8
33
2.47
1.55
1.1
1.2
—
—
—
0
0
186
2015
0.71
1.54
6.7
4.5
7.11
5.92
mmol/l
8.15
168
1853
0
42
0.00
1.54
0.0
1.5
—
—
—
0
0
0
42
0.00
1.54
0.0
1.5
—
—
—
0
0
20
116
1.79
1.54
13.7
9.1
0.71
0.71
%
0.01
20
116
0
43
0.00
1.53
0.0
1.6
—
—
—
0
0
5
15
3.38
1.53
3.8
2.4
2.97
1.07
e9/l
—
5
5
13
65
2.05
1.51
1.8
1.5
—
—
—
0
0
92
751
1.35
1.48
5.0
3.6
31.19
40.20
ng/l
0.50
71
499
11
211
0.50
1.46
1.0
1.4
—
—
—
0
0
5
16
3.17
1.44
1.0
1.1
—
—
—
0
0
5
16
3.17
1.44
1.4
1.1
—
—
—
0
0
63
486
1.39
1.43
4.2
3.6
—
—
—
0
0
24
151
1.65
1.41
2.0
2.5
—
18.12
—
0
5
9
41
2.24
1.38
1.3
1.2
4.53
3.65
mmol/l
—
9
35
71
562
1.37
1.38
4.5
3.0
—
—
—
0
0
35
243
1.51
1.37
1.9
1.5
—
—
—
0
0
5
17
2.98
1.36
1.6
3.2
54.26
16.99
ug/l
—
5
17
13
68
1.96
1.36
2.5
3.1
—
—
—
0
0
5
18
2.81
1.29
1.8
1.6
—
—
—
0
0
22
139
1.64
1.28
3.1
2.4
4.67
3.84
e9/l
0.78
16
113
8
37
2.20
1.22
4.3
5.9
—
—
—
0
0
18
109
1.70
1.22
2.6
2.3
—
—
—
0
0
5
19
2.66
1.22
1.8
1.6
29.20
32.89
pg
—
5
19
206
1921
1.38
1.21
7.3
4.8
1.95
1.94
mu/l
0.04
193
1760
19
119
1.64
1.15
1.4
1.3
—
—
—
0
0
26
177
1.52
1.13
5.9
3.5
—
—
—
0
0
5
21
2.41
1.09
4.6
1.3
87.10
90.56
%
—
5
21
7
32
2.22
1.09
1.0
1.0
—
—
—
0
0
7
34
2.09
1.03
2.7
1.8
—
—
—
0
0
9
47
1.95
1.03
1.3
1.3
666.33
446.52
mg/l
—
9
42
22
148
1.53
1.02
3.1
4.1
0.00
0.32
%
—
5
31
13
76
1.75
1.01
1.8
1.5
—
—
—
0
0
70
579
1.29
0.99
5.9
3.7
—
—
—
0
0
16
100
1.64
0.99
1.1
1.1
—
—
—
0
0
5
23
2.20
0.98
1.2
3.4
—
—
—
0
0
7
36
1.97
0.98
2.4
3.2
59.00
61.47
%
—
7
36
20
134
1.53
0.95
3.6
2.6
—
—
—
0
0
7
37
1.92
0.95
1.0
1.4
—
—
—
0
0
7
37
1.92
0.95
2.9
1.3
—
—
—
0
0
6
27
2.25
0.94
1.2
1.2
—
—
—
0
0
25
177
1.46
0.92
1.3
1.2
—
—
—
0
0
22
152
1.49
0.91
1.1
1.2
169.86
152.17
iu/ml
—
7
60
6
30
2.02
0.87
6.3
2.5
—
—
—
0
0
21
146
1.48
0.85
3.2
4.3
0.00
0.00
%
—
7
36
153
1403
1.23
0.84
5.2
3.0
74.55
44.99
u/l
2.14
141
1309
22
155
1.46
0.84
3.1
4.2
0.17
0.20
%
—
6
44
33
254
1.34
0.78
1.2
1.3
—
—
—
0
0
12
75
1.63
0.76
1.4
1.2
—
—
—
0
0
168
1565
1.22
0.75
6.1
4.0
15.92
11.32
mm/h
2.82
157
1422
56
467
1.26
0.75
4.1
3.9
1.02
1.02
kg/l
0.43
12
59
23
168
1.41
0.74
3.0
4.1
0.50
0.76
%
—
6
50
66
766
0.81
0.72
3.3
2.8
—
—
—
0
0
5
26
1.94
0.71
1.0
1.0
—
—
—
0
0
7
42
1.69
0.69
1.4
1.4
2.14
236.91
e6/l
—
7
33
7
42
1.69
0.69
1.4
1.3
77.00
3.55
e6/l
—
7
31
24
180
1.37
0.68
1.5
1.5
—
—
—
0
0
172
1615
1.20
0.67
6.0
4.0
14.94
14.70
pmol/l
0.61
162
1466
226
2324
0.75
0.67
44.3
19.3
129.35
135.67
g/l
7.56
226
2289
226
2322
0.76
0.63
43.8
19.2
29.98
30.27
pg
1.56
226
2288
226
2322
0.76
0.63
44.0
19.3
4.36
4.50
e12/l
3.15
220
2258
226
2322
0.76
0.63
43.9
19.3
7.22
6.65
e9/l
3.51
220
2261
226
2321
0.76
0.62
43.8
19.2
90.71
90.92
fl
0.27
226
2287
206
1975
1.23
0.60
5.2
4.0
1.36
1.28
mmol/l
0.46
188
1822
12
81
1.51
0.58
1.2
1.1
—
—
—
0
0
6
36
1.68
0.57
2.5
2.7
4.84
5.01
e9/l
—
6
36
217
2095
1.25
0.57
30.5
13.1
25.43
21.93
mg/l
0.88
186
1609
13
91
1.45
0.54
1.3
1.2
—
—
—
0
0
42
353
1.23
0.54
1.2
1.3
29.89
26.78
iu/ml
0.08
12
116
15
201
0.73
0.51
1.3
1.3
—
—
—
0
0
20
154
1.32
0.50
1.3
1.5
—
—
—
0
0
7
45
1.57
0.49
3.0
1.9
—
—
—
0
0
7
47
1.50
0.48
2.1
1.1
—
—
—
0
0
7
48
1.47
0.47
4.6
3.5
15.43
31.42
u/ml
—
7
48
91
831
1.15
0.46
2.3
2.1
—
—
—
0
0
13
96
1.37
0.42
2.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
5
35
1.44
0.39
8.0
3.4
—
—
—
0
0
5
37
1.36
0.37
1.6
1.4
—
—
—
0
0
215
2095
1.17
0.36
6.9
4.9
2.34
2.80
mmol/l
12.31
202
1936
51
568
0.87
0.35
1.5
1.5
—
—
—
0
0
6
45
1.34
0.34
2.3
1.6
—
—
—
0
0
13
101
1.30
0.32
2.6
3.4
—
—
—
0
0
194
1890
1.11
0.27
33.3
14.0
38.04
40.00
%
2.17
150
1412
174
1788
0.91
0.24
39.7
17.1
329.60
332.32
g/l
3.00
174
1779
61
567
1.10
0.23
5.4
3.8
0.00
0.00
estimate
0.00
28
191
26
293
0.87
0.22
2.7
2.7
0.59
0.71
ug/l
0.48
20
178
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
4.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
7.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
15870.00
—
0
7
0
14
0.00
0.20
0.0
1.3
—
2502.67
—
0
9
6
51
1.18
0.19
1.7
1.3
—
—
—
0
0
6
53
1.14
0.19
1.2
1.4
—
2.23
—
0
11
7
58
1.21
0.18
2.0
4.3
—
—
—
0
0
7
60
1.17
0.18
1.6
1.4
—
—
—
0
0
7
60
1.17
0.18
16.6
3.1
3.86
3.96
mmol/l
—
7
55
7
60
1.17
0.18
1.6
1.4
—
—
—
0
0
7
61
1.15
0.17
1.6
1.4
—
—
—
0
0
7
62
1.13
0.17
1.6
1.4
—
—
—
0
0
7
62
1.13
0.17
1.6
1.4
—
—
—
0
0
5
66
0.75
0.17
1.2
1.3
—
2.00
—
0
5
208
2048
1.09
0.16
6.0
4.4
1.42
1.50
mmol/l
1.86
193
1894
15
172
0.86
0.16
2.0
1.6
—
—
—
0
0
9
79
1.14
0.15
19.6
3.7
—
—
—
0
0
45
475
0.94
0.12
5.5
4.9
—
—
—
0
0
219
2171
1.06
0.09
28.4
12.1
—
—
—
0
0
33
347
0.94
0.08
1.3
1.3
29.90
8.35
u/ml
0.53
13
134
6
73
0.82
0.07
16.5
9.7
—
—
—
0
0
19
178
1.07
0.06
5.5
3.5
—
—
—
0
0
207
2058
1.03
0.04
6.0
4.5
4.23
4.74
mmol/l
10.00
192
1912
222
2212
1.03
0.02
18.0
10.1
27.24
26.33
u/l
0.32
217
2124
11
117
0.94
0.02
1.2
1.3
—
—
—
0
0
21
213
0.98
0.00
2.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
6.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
14.46
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
11.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
34.92
—
0
6
0
5
0.00
0.00
0.0
9.6
—
5.18
—
0
5

Mortality – FinRegistry

Association

Association between endpoint E4_PANCSECNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PANCSECNAS 2.933 [2.09, 4.12] < 0.001
Birth year 0.991 [0.98, 1.0] 0.055

During the follow-up period (1.1.1998 — 31.12.2019), 166 out of 473 females with E4_PANCSECNAS died.

Males

Parameter HR [95% CI] p-value
E4_PANCSECNAS 4.546 [3.15, 6.57] < 0.001
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 479 males with E4_PANCSECNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_PANCSECNAS.

N-year risk Females Males
1 0.191% 0.945%
5 1.541% 5.339%
10 4.135% 12.739%
15 7.215% 22.267%
20 12.337% 36.003%

Relationships between endpoints

Index endpoint: E4_PANCSECNAS – Disorder of pancreatic internal secretion, other and/or unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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