No definition available.
Disorder of pancreatic internal secretion, other and/or unspecified
DOID EFO Endpoint Browser PheWeb
E4_PANCSECNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
254 |
4. Check minimum number of eventsNone |
254 |
5. Include endpointsNone |
254 |
6. Filter based on genotype QC (FinnGen only) |
254 |
Control definitions (FinnGen only)
- Control exclude
- E4_GLUCOPANCREAS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorder of pancreatic internal secretion, other and/or unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders of glucose regulation and pancreatic internal secretion
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1896 | 1059 | 820 |
| Only index persons | 1511 | 896 | 615 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 44.97 | 39.12 | 52.19 |
| Only index persons | 42.06 | 36.45 | 50.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 254 | 161 | 93 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | 41.43 | 34.97 | 52.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 232
- Matched controls
- 2319
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E16.9
ICD-10 Finland
Disorder of pancreatic internal secretion, unspecified
+∞
98.0
87
*
25109
ICD-8 Finland
Disorders of pancreatic internal secretion other than diabetes mellitus, Unspecified
+∞
63.5
58
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
17.5
49.5
82
70
A10AE04
ATC
insulin glargine; parenteral
13.4
46.1
87
99
A09AA02
ATC
multienzymes (lipase, protease etc.)
47.5
45.7
55
15
103
Kela drug reimbursment
Diabetes, insulin-treated
7.7
44.4
139
375
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
15.6
44.0
76
70
E16.89
ICD-10 Finland
Other specified disorders of pancreatic internal secretion
+∞
43.1
40
*
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
61.7
42.7
49
10
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
21.7
42.1
63
39
T89
ICPC
Diabetes insulin dependent
28.6
41.8
57
26
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
30.9
41.2
55
23
A10AA02
ATC
NA
27.6
37.8
52
24
215
Kela drug reimbursment
Diabetes, non-insulin-treated
6.6
37.0
124
342
A10AE05
ATC
insulin detemir; parenteral
15.9
36.7
62
52
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
33.4
35.4
46
17
A10AA01
ATC
NA
29.0
31.9
43
18
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
29.0
30.5
41
17
H04AA01
ATC
glucagon; nasal, parenteral
28.1
28.1
38
16
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
26.4
27.6
38
17
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
110.0
27.3
29
*
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
18.7
27.2
42
27
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
34.7
25.8
33
11
A10AE06
ATC
insulin degludec; parenteral
21.8
25.3
37
20
H3603, E103
ICD-10 Finland
NA
44.3
19.9
24
6
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
34.8
19.7
25
8
E10
ICD-10 Finland
Type 1 diabetes mellitus
21.0
19.2
28
15
E16.19
ICD-10 Finland
Other specified hypoglycaemia
+∞
19.0
18
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.1
18.8
89
304
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
46.0
17.6
21
5
SPAT1262
SPAT
Handing over of treatment supplies
4.2
17.6
77
243
T90
ICPC
Diabetes non-insulin dependent
3.9
16.5
82
287
XCK10
NOMESCO Finland
Photography of fundus of eye
5.4
16.5
53
120
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
38.8
14.7
18
5
H3600, E103
ICD-10 Finland
NA
24.2
14.5
20
9
K90.3
ICD-10 Finland
Pancreatic steatorrhoea
45.7
14.3
17
*
2518X
ICD-9 Finland
Other disorders of pancreatic internal secretion, Other specified disorders of pancreatic internal secretion
+∞
13.7
13
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
30.4
13.2
17
6
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
30.4
13.2
17
6
E16.85
ICD-10 Finland
Zollinger-Ellison syndrome
+∞
12.6
12
*
A10BA02
ATC
metformin; oral
3.1
12.6
88
384
25108
ICD-8 Finland
Disorders of pancreatic internal secretion other than diabetes mellitus, Alia definita
+∞
11.6
11
*
E16.0
ICD-10 Finland
Drug-induced hypoglycaemia without coma
+∞
11.6
11
*
H3601, E103
ICD-10 Finland
NA
126.0
11.5
12
*
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
14.9
11.2
18
13
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
10.9
51
164
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
7.2
10.9
26
40
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
29.6
10.9
14
5
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
13.8
10.8
18
14
2519X
ICD-9 Finland
Other disorders of pancreatic internal secretion, Unspecified disorder of pancreatic internal secretion
+∞
10.5
10
*
25009
ICD-8 Finland
Diabetes mellitus, Unspecified
42.0
10.1
12
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
27.4
9.9
13
5
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
9.6
49
168
E16.80
ICD-10 Finland
Hypergastrinaemia
+∞
9.4
9
*
177
Kela drug reimbursment
Insulin glargine 300 U / ml
12.2
9.2
16
14
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
38.3
9.1
11
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
25.2
9.0
12
5
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
13.3
9.0
15
12
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
9.2
9.0
18
21
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
52.0
8.7
10
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.5
8.7
22
37
ZXA00
NOMESCO Finland
Right side
2.5
8.5
79
395
K86.1
ICD-10 Finland
Other chronic pancreatitis
13.4
8.5
14
11
RJ410
NOMESCO Finland
NA
93.3
8.5
9
*
RJ420
NOMESCO Finland
NA
93.3
8.5
9
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
9.1
8.5
17
20
B81
ICPC
Anaemia vit B12/folate deficiency
9.1
8.5
17
20
TK800
NOMESCO Finland
Hemodialysis
11.4
8.4
15
14
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.5
8.4
78
389
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
+∞
8.4
8
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
8.4
80
406
C03CA01
ATC
furosemide; systemic
2.5
8.2
73
357
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
34.7
8.1
10
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.0
8.1
49
189
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
23.0
8.1
11
5
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.8
8.1
22
41
CKC10
NOMESCO Finland
Local photocoagulation of retina
13.7
8.0
13
10
CKC12
NOMESCO Finland
Photocoagulation of retina
5.7
7.9
22
42
B03BA03
ATC
hydroxocobalamin; parenteral
6.0
7.9
21
38
Y6099
ICD-8 Finland
Prenatal care and observation
4.7
7.8
26
61
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
15.7
7.8
12
8
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.3
7.7
15
17
R4110
NOMESCO Finland
Physiotherapy
2.4
7.6
77
400
E13.8
ICD-10 Finland
Other specified diabetes mellitus, with unspecified complications
+∞
7.3
7
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
7.3
52
222
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
7.7
7.3
16
22
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.7
7.2
31
93
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.8
7.2
23
52
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
20.8
7.2
10
5
A10AA03
ATC
NA
20.8
7.2
10
5
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.3
7.2
21
43
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
5.5
7.1
20
39
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
7.0
60
283
A10BB12
ATC
glimepiride; oral
4.3
7.0
25
63
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.9
7.0
46
185
H3601, E113
ICD-10 Finland
NA
14.4
7.0
11
8
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
6.9
107
664
H36.01
ICD-10 Finland
Diabetic maculopathy
41.3
6.8
8
*
E13
ICD-10 Finland
Other specified diabetes mellitus
41.3
6.8
8
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.0
6.7
26
71
6480A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Diabetes mellitus
23.3
6.7
9
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
12.8
6.6
11
9
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
7.8
6.5
14
19
RJ421
NOMESCO Finland
NA
71.7
6.5
7
*
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
71.7
6.5
7
*
A12AA04
ATC
calcium carbonate; oral
14.8
6.5
10
7
TPH07
NOMESCO Finland
Cathetrisation of artery
3.2
6.4
33
115
WX002
NOMESCO Finland
Sedation and analgesia
2.4
6.4
56
268
127
Kela drug reimbursment
Transplant complication
18.6
6.3
9
5
E16.10
ICD-10 Finland
Hyperinsulinism
+∞
6.3
6
*
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
6.1
6.3
16
28
Z94.0
ICD-10 Finland
Kidney transplant status
27.5
6.3
8
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
27.5
6.3
8
*
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
3.4
6.3
29
93
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.0
6.2
35
129
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
6.2
61
309
NHQ40
NOMESCO Finland
Amputation of toe
13.0
6.1
10
8
L04AA06
ATC
mycophenolic acid; systemic
13.0
6.1
10
8
H43.1
ICD-10 Finland
Vitreous haemorrhage
7.0
6.1
14
21
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
9.0
6.1
12
14
205
Kela drug reimbursment
Chronic hypertension
2.2
6.1
68
361
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
10.4
6.1
11
11
Mortality – FinRegistry
↥Association
Association between endpoint E4_PANCSECNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PANCSECNAS | 2.933 [2.09, 4.12] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 166 out of 473 females with E4_PANCSECNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PANCSECNAS | 4.546 [3.15, 6.57] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 479 males with E4_PANCSECNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_PANCSECNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.191% | 0.945% |
| 5 | 1.541% | 5.339% |
| 10 | 4.135% | 12.739% |
| 15 | 7.215% | 22.267% |
| 20 | 12.337% | 36.003% |
Relationships between endpoints
↥Index endpoint: E4_PANCSECNAS – Disorder of pancreatic internal secretion, other and/or unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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