No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
408 |
4. Check minimum number of eventsNone |
408 |
5. Include endpointsNone |
408 |
6. Filter based on genotype QC (FinnGen only) |
397 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Thyrotropin deficiency
based on the number of shared cases.
Similar with more cases:
- Hypopituitarism
- Exclusions for E4_PCOS_BROAD
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
- Disorders of other endocrine glands
- Exclusions for E4_PCOS_CONSORTIUM
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 397 | 293 | 104 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.05 |
| Median age at first event (years) | 51.06 | 48.34 | 58.70 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 408
- Matched controls
- 4080
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E23.05
ICD-10 Finland
Lack of TSH
+∞
307.7
408
*
H03AA01
ATC
levothyroxine sodium; systemic
120.0
287.1
391
656
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
157.8
245.3
122
11
H02AB09
ATC
hydrocortisone; systemic
47.4
197.3
121
36
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
189.8
110.5
111
8
E23.00
ICD-10 Finland
Panhypopituitarism
445.1
76.5
74
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
6.9
74.8
157
341
101
Kela drug reimbursment
Anterior pituitary hypofunction
112.7
69.6
74
8
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
13.6
67.1
67
58
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
171.8
57.6
59
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
10.6
51.4
60
65
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
9.0
39.7
52
65
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
208.9
37.5
38
*
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
33.9
31.0
40
13
E22.1
ICD-10 Finland
Hyperprolactinaemia
73.9
30.4
34
5
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
12.3
30.4
31
27
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
29.5
28
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.9
29.1
104
327
E23.03
ICD-10 Finland
Lack of ACTH
155.7
28.0
29
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.4
27.5
78
206
N04BC06
ATC
cabergoline; oral
53.7
25.6
30
6
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
127.2
22.8
24
*
XCK00
NOMESCO Finland
Perimetry
5.2
21.9
48
102
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
231.9
21.8
22
*
N06AX16
ATC
venlafaxine; oral
3.2
21.3
105
399
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.6
21.0
35
57
N05AH04
ATC
quetiapine; oral
3.0
20.7
116
474
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.1
18.1
53
142
H01AC01
ATC
somatropin; parenteral
44.1
17.4
21
5
N06AX21
ATC
duloxetine; oral
3.1
17.4
85
319
ZXC86
NOMESCO Finland
Use of endoscopic device
52.4
17.1
20
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.8
17.0
56
163
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.3
17.0
74
259
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
16.8
16
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.0
16.8
52
145
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.3
15.8
67
230
E23.2
ICD-10 Finland
Diabetes insipidus
88.6
15.7
17
*
E23.06
ICD-10 Finland
Empty sella
166.1
15.6
16
*
N05BA04
ATC
oxazepam; oral
2.4
14.8
139
720
N06AB10
ATC
escitalopram; oral
2.4
14.5
128
644
R53
ICD-10 Finland
Malaise and fatigue
2.4
14.1
130
666
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
77.8
13.7
15
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.6
13.7
99
453
G47.3
ICD-10 Finland
Sleep apnoea
2.4
13.4
113
555
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.2
13.3
37
95
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.9
13.3
30
65
N06AX12
ATC
bupropion; oral
3.2
12.9
54
183
102
Kela drug reimbursment
Diabetes insipidus
72.2
12.7
14
*
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
72.2
12.7
14
*
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
5.5
12.6
25
48
N06AX11
ATC
mirtazapine; oral
2.2
12.6
165
970
N03AF02
ATC
oxcarbazepine; oral
4.7
12.3
29
65
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
38.8
12.3
15
*
H53.4
ICD-10 Finland
Visual field defects
6.3
12.2
21
35
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
11.6
12.2
22
20
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.7
12.1
40
116
N06AB04
ATC
citalopram; systemic
2.3
11.9
107
538
E23.08
ICD-10 Finland
Hypopituitarism
+∞
11.5
11
*
N03AX09
ATC
lamotrigine; oral
3.5
11.3
40
122
N06AX26
ATC
vortioxetine; oral
3.1
11.2
50
176
SPAT1249
SPAT
Treatment-related counselling outside office
2.1
11.2
181
1141
E66.8
ICD-10 Finland
Other obesity
3.5
11.1
40
123
N91.1
ICD-10 Finland
Secondary amenorrhoea
8.3
10.7
23
29
AA1AD
NOMESCO Finland
CT of head and brain
2.2
10.7
108
567
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.8
10.4
33
93
SPAT1234
SPAT
Support of social functional capacity
4.6
10.4
25
57
E66.01
ICD-10 Finland
Obesity due to excess calories
2.7
10.2
59
240
SPAT1243
SPAT
Psychiatric/psychological examination
4.7
10.2
24
54
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.1
10.1
125
709
301
Kela drug reimbursment
Growth hormone
41.1
10.0
12
*
E03
ICD-10 Finland
Other hypothyroidism
3.3
10.0
40
132
N05AH03
ATC
olanzapine; systemic
3.2
9.8
41
139
R06.0
ICD-10 Finland
Dyspnoea
2.1
9.7
116
647
N06AX22
ATC
agomelatine; oral
4.8
9.6
22
48
T86
ICPC
Hypothyroidism/myxoedema
3.9
9.6
29
79
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
4.3
9.6
25
61
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.3
9.6
25
61
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.7
9.4
54
218
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
9.4
9
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
9.3
69
316
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
8.0
9.2
20
26
C02AC05
ATC
moxonidine; oral
5.0
9.2
20
42
SPAT1252
SPAT
Overall medication plan or its review
3.4
9.0
33
103
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.1
9.0
21
31
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
24.7
9.0
12
5
N05AF03
ATC
chlorprothixene; systemic
4.7
8.9
21
47
R51.80
ICD-10 Finland
Headache
2.2
8.9
90
469
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
8.9
94
499
N06AX03
ATC
mianserin; oral
3.7
8.8
28
79
N03AE01
ATC
clonazepam; systemic
3.3
8.6
33
106
G02CB01
ATC
bromocriptine; systemic
4.8
8.4
19
41
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
8.4
8
*
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.4
8.3
63
290
L28
ICPC
Limited function/disability (L)
2.3
8.3
67
318
SPAT1240
SPAT
Therapeutic discussion
2.4
8.3
64
298
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.9
8.2
131
805
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.8
8.2
43
166
N05BA01
ATC
diazepam; systemic, rectal
2.4
8.2
63
293
P76
ICPC
Depressive disorder
2.7
8.2
45
178
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.4
8.1
29
89
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.8
8.1
43
167
N03AX12
ATC
[U] gabapentin; oral
2.2
8.1
79
406
H47.2
ICD-10 Finland
Optic atrophy
22.5
8.1
11
5
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
7.9
55
244
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.4
7.9
56
251
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
4.0
7.8
22
57
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
7.8
125
768
N05BA12
ATC
alprazolam; oral
2.5
7.6
52
228
N05CF02
ATC
zolpidem; oral
2.1
7.6
87
474
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
10.3
7.6
14
14
N05CD07
ATC
temazepam; oral
2.6
7.6
45
185
N06AB03
ATC
fluoxetine; oral
2.3
7.5
64
310
N03AG01
ATC
valproic acid; systemic, rectal
2.9
7.5
36
132
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
7.4
129
811
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.4
7.3
51
226
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.6
7.3
42
170
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
7.3
96
550
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
3.7
7.2
23
65
SPAT1153
SPAT
Removal of sutures
1.9
7.2
123
768
SPAT1216
SPAT
Assessment of functional ability
2.3
7.1
59
282
N05AX12
ATC
aripiprazole; systemic
3.3
7.1
27
86
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.2
7.1
61
297
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
7.1
188
1337
G44.2
ICD-10 Finland
Tension-type headache
2.1
7.0
74
390
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
6.9
6.9
16
24
E86
ICD-10 Finland
Volume depletion
8.5
6.9
14
17
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
6.8
166
1148
SPAT1263
SPAT
Sampling
1.7
6.8
173
1211
F31.8
ICD-10 Finland
Other bipolar affective disorders
4.4
6.8
17
40
C03CA01
ATC
furosemide; systemic
2.0
6.8
88
500
R50.9
ICD-10 Finland
Fever, unspecified
2.1
6.8
68
352
SPAT1262
SPAT
Handing over of treatment supplies
2.1
6.7
66
338
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
6.7
113
700
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
6.1
6.7
17
29
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
12.5
6.6
11
9
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.2
6.6
56
271
N06AB06
ATC
sertraline; oral
2.1
6.5
64
328
P03
ICPC
Feeling depressed
2.2
6.5
57
280
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.1
6.4
27
92
CS494
NOMESCO Finland
Other visual field testing
5.3
6.4
18
35
A02BC02
ATC
pantoprazole; systemic
1.7
6.4
266
2119
N02AA05
ATC
oxycodone; systemic
2.1
6.4
64
331
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.2
6.4
54
261
SPAT1312
SPAT
General health counselling
1.8
6.3
134
888
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
5.2
6.3
18
36
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.3
6.2
46
210
SPAT1301
SPAT
No procedures
1.8
6.2
125
816
N30.0
ICD-10 Finland
Acute cystitis
2.0
6.2
73
401
N05AN01
ATC
lithium; oral
3.9
6.2
18
48
A46
ICD-10 Finland
Erysipelas
2.2
6.1
52
251
C07AA05
ATC
propranolol; systemic
1.8
6.1
101
620
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.9
6.1
88
517
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
8.8
6.1
12
14
SPAT1307
SPAT
Psychosocial counselling and guidance
2.6
6.1
36
148
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
297
329
30.51
281.65
4.7
1.9
353.21
376.77
nmol/l
0.96
282
309
178
171
17.69
175.02
3.2
1.4
423.63
274.23
mu/l
4.58
169
152
201
241
15.47
171.02
4.0
3.8
4.21
4.64
pmol/l
4.79
188
214
72
11
79.27
133.41
2.3
2.5
0.87
1.47
ug/l
0.53
67
11
134
133
14.51
126.31
1.6
1.3
9.76
10.89
u/l
0.30
116
111
74
79
11.22
64.47
1.8
1.4
16.96
25.30
u/l
1.24
69
66
102
202
6.40
51.86
5.0
2.1
11.58
12.93
nmol/l
0.74
93
192
64
81
9.19
48.68
1.6
1.4
0.41
0.42
nmol/l
0.04
48
66
398
2737
19.53
36.39
11.5
4.1
14.18
14.51
pmol/l
1.51
393
2530
91
241
4.57
32.27
1.8
1.3
20.37
23.28
iu/l
0.40
79
210
34
7
52.81
28.87
1.4
1.6
—
—
—
0
0
237
1315
2.91
24.68
7.0
5.9
1.21
1.22
mmol/l
0.82
227
1221
250
1456
2.85
23.25
7.6
6.6
1.21
1.22
mmol/l
0.46
214
1249
225
1255
2.77
22.53
5.1
4.5
35.59
36.34
g/l
1.20
214
1190
87
318
3.21
18.66
5.5
6.6
105.06
104.31
mmol/l
0.76
87
318
84
306
3.20
18.08
1.2
1.3
32.61
159.62
iu/ml
6.52
37
129
398
3242
10.29
17.99
10.8
4.8
0.87
2.17
mu/l
3.41
372
3019
277
1833
2.59
17.90
5.9
4.5
6.30
6.49
mmol/l
1.03
263
1672
166
871
2.53
17.76
4.8
3.6
0.00
0.01
estimate
0.80
65
328
150
770
2.50
16.62
2.8
2.1
2.92
2.91
mg/l
0.02
137
677
337
2536
2.89
15.43
8.2
6.8
76.57
76.30
u/l
0.04
323
2397
333
2509
2.78
14.86
4.5
3.9
9.93
10.38
mm/h
0.30
311
2332
85
360
2.72
13.70
10.2
5.9
—
—
—
0
0
245
1647
2.22
13.61
3.8
2.8
91.78
92.19
ug/l
0.02
236
1547
38
98
4.17
13.58
1.7
1.9
2.26
6.34
iu/l
1.69
13
33
218
1404
2.19
13.43
3.0
2.3
78.05
75.55
nmol/l
0.70
206
1292
193
1190
2.18
13.22
2.1
1.8
99.04
96.51
pmol/l
0.27
116
605
23
40
6.03
12.88
1.6
1.1
—
—
—
0
0
83
368
2.58
12.12
2.6
2.3
24.24
23.17
%
0.30
69
313
272
1956
2.17
12.10
9.7
8.9
4.00
4.01
e9/l
0.04
254
1712
171
1036
2.12
11.96
3.4
3.1
2.33
2.35
mmol/l
1.29
155
935
166
998
2.12
11.81
3.3
2.4
53.13
61.85
u/l
0.99
154
929
157
928
2.12
11.65
2.2
2.0
161.42
190.31
u/l
0.43
146
882
200
1295
2.07
11.61
4.8
3.4
—
—
—
0
0
180
1127
2.07
11.39
3.9
3.2
33.45
28.66
ng/l
0.15
116
661
86
399
2.46
11.36
2.7
2.3
2.38
2.42
g/l
0.27
79
370
241
1679
2.06
11.35
4.6
3.4
0.00
0.00
estimate
-0.00
66
321
397
3455
6.53
11.27
21.7
12.8
3.94
3.94
mmol/l
0.09
392
3358
92
443
2.39
11.19
2.6
2.3
13.73
14.00
umol/l
0.13
86
411
237
1655
2.03
10.93
5.7
4.6
0.00
0.00
estimate
0.50
66
330
114
616
2.18
10.48
1.8
1.6
36190942.70
455.41
pmol/l
0.50
105
533
235
1654
1.99
10.39
4.6
3.4
0.00
0.00
estimate
-0.00
68
347
24
56
4.49
9.72
3.0
2.7
16.69
15.42
%
0.70
12
25
123
703
2.07
9.67
2.6
3.0
2453.04
839.71
ng/l
0.43
100
591
102
543
2.17
9.65
2.6
2.6
2.42
2.44
mmol/l
0.97
87
480
118
672
2.06
9.33
1.5
1.5
21.41
21.39
nmol/l
0.00
105
578
65
290
2.48
9.25
4.9
9.1
0.92
1.07
mmol/l
0.20
48
240
75
358
2.34
9.19
5.5
5.7
1.04
1.03
mmol/l
0.15
75
332
95
501
2.17
9.16
1.9
1.6
1638.17
1186.16
nmol/l
3.06
82
389
362
3059
2.63
9.14
6.6
5.0
38.65
38.90
mmol/mol
0.21
352
2886
170
1109
1.91
9.04
3.3
2.9
—
—
—
0
0
189
1282
1.88
8.86
11.7
9.8
1.05
1.17
inr
4.05
66
422
230
1666
1.87
8.72
6.4
5.6
8.61
10.22
umol/l
4.48
217
1571
45
173
2.80
8.60
7.8
6.5
24.86
24.72
mmol/l
0.11
45
173
13
9
14.87
8.25
2.8
1.3
225.08
80.00
nmol/24h
—
13
9
375
3278
2.78
7.82
5.5
4.0
5.78
5.82
mmol/l
0.22
364
3051
88
489
2.02
7.26
3.0
3.4
0.81
0.82
mmol/l
0.43
82
468
368
3236
2.40
6.71
15.8
10.5
87.97
87.31
ml/min/173m2
0.22
325
2624
15
23
6.73
6.39
1.2
1.4
—
—
—
0
0
385
3473
2.93
6.35
17.5
11.7
17.33
20.66
mg/l
1.86
322
2665
31
115
2.84
6.34
4.2
3.1
39.05
50.31
%
1.40
31
115
215
1622
1.69
6.28
5.5
5.9
31.73
28.90
%
3.34
209
1537
214
1614
1.69
6.24
5.3
5.7
53.80
56.77
%
3.05
208
1528
78
439
1.96
6.15
1.8
1.8
—
—
—
0
0
16
39
4.23
6.14
1.9
1.7
89.12
91.27
%
0.93
16
39
113
727
1.77
5.82
4.8
3.4
1.02
1.02
kg/l
0.10
11
99
209
1593
1.64
5.65
2.5
2.5
—
—
—
0
0
128
870
1.69
5.36
3.0
2.7
0.19
0.31
e6/l
1.12
106
633
118
787
1.70
5.29
2.0
2.5
314.67
5342.93
umol/l
2.92
103
695
44
211
2.22
5.29
2.3
2.1
3.31
8.06
ug/l
2.26
39
190
130
892
1.67
5.23
1.3
1.3
0.77
1.46
u/ml
1.34
52
257
56
297
2.03
5.20
1.7
1.7
—
—
—
0
0
57
306
2.00
5.12
1.8
1.8
—
—
—
0
0
395
3668
3.41
5.08
12.9
9.3
27.92
25.48
u/l
1.58
390
3556
46
229
2.14
5.04
6.0
3.9
2.30
1.82
mmol/l
0.43
36
183
36
163
2.33
4.95
3.6
3.3
2.78
1.84
mmol/l
0.90
23
118
20
69
3.00
4.67
5.5
2.4
5.05
4.95
kpa
0.27
20
69
44
222
2.10
4.67
2.5
3.6
109.94
75.95
ng/l
0.41
37
206
41
204
2.12
4.51
1.7
1.6
—
—
—
0
0
36
170
2.23
4.50
1.4
1.4
—
—
—
0
0
14
41
3.50
4.22
1.1
1.6
—
—
—
0
0
21
81
2.68
4.04
1.2
1.2
—
—
—
0
0
40
211
1.99
3.79
2.0
2.1
5131.70
3979.29
u/l
0.08
11
82
28
130
2.24
3.67
6.9
3.2
1.02
1.19
%
0.56
28
130
152
1161
1.49
3.61
3.7
3.1
29.43
29.66
u/l
0.05
141
1111
371
3426
1.91
3.57
5.5
4.5
2.79
2.85
mmol/l
0.67
359
3217
27
125
2.24
3.56
6.9
3.2
0.55
0.63
%
0.91
27
125
367
3378
1.86
3.56
5.1
4.1
4.65
4.77
mmol/l
1.68
354
3187
11
26
4.32
3.53
1.1
1.6
—
—
—
0
0
403
3890
3.94
3.49
28.6
17.5
4.50
4.51
e12/l
0.13
398
3795
403
3888
3.98
3.49
28.3
17.5
40.40
40.34
%
0.09
386
3701
403
3887
4.00
3.49
28.6
17.5
258.24
257.72
e9/l
0.06
398
3802
279
2413
1.49
3.46
3.9
3.0
43.51
42.68
u/l
0.07
262
2291
107
775
1.52
3.23
1.8
2.0
—
—
—
0
0
14
49
2.92
3.22
1.3
1.6
—
—
—
0
0
13
40
3.32
3.17
1.2
1.3
—
—
—
0
0
364
3365
1.76
3.16
5.0
4.0
1.39
1.50
mmol/l
6.67
352
3160
13
44
3.02
3.16
1.3
1.3
—
—
—
0
0
121
905
1.48
3.12
3.6
3.0
8.04
7.78
mmol/l
0.21
109
785
32
168
1.98
3.09
1.4
1.4
—
—
—
0
0
17
69
2.53
3.00
1.4
1.6
—
—
—
0
0
7
13
5.46
2.88
1.7
1.4
—
—
—
0
0
351
3233
1.61
2.86
4.7
3.7
1.47
1.25
mmol/l
5.25
340
3024
91
655
1.50
2.81
1.3
1.3
12.88
32.69
iu/ml
4.28
20
216
5
6
8.42
2.75
1.2
1.0
—
—
—
0
0
17
73
2.39
2.69
1.3
1.5
—
—
—
0
0
71
489
1.55
2.68
1.9
1.6
1.39
1.38
%
0.05
65
444
72
499
1.54
2.64
2.4
2.4
1.36
0.97
e6/l
0.51
48
272
110
832
1.44
2.63
4.2
3.8
8.74
8.46
mg/mmol
0.02
75
528
11
36
3.11
2.58
1.1
1.6
—
—
—
0
0
61
415
1.55
2.44
1.7
1.9
28.70
29.41
s
0.79
61
403
115
897
1.39
2.29
1.7
1.7
1.76
1.39
mmol/l
2.25
98
780
101
771
1.41
2.27
1.7
1.7
0.61
1.08
mg/l
2.30
83
583
86
640
1.44
2.22
5.8
4.3
1.54
2.42
ug/l
1.03
78
575
11
41
2.73
2.22
1.5
1.1
—
—
—
0
0
24
130
1.90
2.17
1.7
1.7
—
—
—
0
0
86
644
1.42
2.15
1.3
1.3
5.86
8.52
u/ml
0.23
36
273
27
153
1.82
2.14
3.3
2.9
0.41
0.10
e6/l
0.47
27
148
66
473
1.47
2.08
2.8
2.5
5.70
2.75
e6/l
0.73
43
244
7
21
3.37
1.97
3.3
2.3
—
—
—
0
0
5
11
4.59
1.94
1.2
3.0
76.12
103.75
ug/l
—
5
11
20
110
1.86
1.76
1.5
1.2
—
2.00
—
0
7
45
313
1.49
1.66
6.1
3.2
—
—
—
0
0
19
105
1.85
1.66
1.5
1.2
—
15.53
—
0
20
10
41
2.47
1.65
2.5
3.1
—
1265.40
—
0
5
36
239
1.56
1.64
1.6
1.2
58.74
33.40
au/ml
—
5
16
13
64
2.07
1.55
1.3
1.3
—
—
—
0
0
281
2582
1.28
1.54
3.4
3.5
—
—
—
0
0
17
93
1.86
1.54
1.6
1.3
355.22
317.57
ug/g
—
9
50
37
253
1.51
1.49
2.1
2.3
79.11
73.30
ml/min/173m2
0.42
18
105
15
80
1.91
1.46
1.4
1.2
—
1.23
—
0
6
10
199
0.49
1.44
1.6
1.5
—
—
—
0
0
5
16
3.15
1.44
1.4
1.1
2097.60
1676.13
miu/ml
—
5
16
6
22
2.75
1.44
2.3
3.0
—
—
—
0
0
16
88
1.85
1.43
1.3
1.2
—
31.13
—
0
10
15
81
1.88
1.42
4.3
1.6
—
—
—
0
0
17
96
1.80
1.41
1.6
2.5
6.95
10.92
mg/l
1.85
17
91
11
53
2.11
1.39
4.2
2.5
6.17
7.36
mmol/l
1.46
11
53
5
17
2.96
1.36
1.2
1.6
—
—
—
0
0
10
190
0.51
1.27
1.4
1.4
—
—
—
0
0
10
190
0.51
1.27
1.4
1.4
—
—
—
0
0
48
358
1.39
1.26
1.8
1.8
—
—
—
0
0
10
189
0.52
1.26
1.4
1.4
—
—
—
0
0
10
189
0.52
1.26
1.4
1.4
—
—
—
0
0
6
25
2.42
1.25
1.3
1.3
—
—
—
0
0
11
56
1.99
1.23
2.1
1.8
—
—
—
0
0
5
19
2.65
1.22
2.0
3.5
—
—
—
0
0
19
118
1.64
1.17
1.8
1.6
—
—
—
0
0
38
276
1.42
1.17
1.7
1.7
—
—
—
0
0
21
134
1.60
1.17
1.6
1.7
—
—
—
0
0
14
81
1.75
1.10
1.4
1.4
—
—
—
0
0
10
53
1.91
1.02
1.0
1.1
2.40
11.94
iu/ml
—
5
16
5
23
2.19
0.98
1.6
1.3
110.10
168.88
pmol/l
—
5
23
64
520
1.27
0.97
4.9
3.8
20.38
21.13
%
0.15
34
223
98
839
1.22
0.94
1.7
1.6
—
—
—
0
0
6
27
2.24
0.94
1.5
1.6
—
—
—
0
0
46
361
1.31
0.91
4.0
3.9
31.07
32.24
%
0.30
40
262
6
31
1.95
0.84
1.7
1.6
—
—
—
0
0
6
31
1.95
0.84
1.7
1.6
—
—
—
0
0
10
57
1.77
0.84
1.3
1.9
—
—
—
0
0
16
106
1.53
0.80
1.1
1.9
—
—
—
0
0
30
392
0.75
0.79
1.3
1.6
—
—
—
0
0
8
48
1.68
0.79
1.8
1.6
—
—
—
0
0
6
34
1.78
0.76
1.2
1.1
—
—
—
0
0
11
67
1.66
0.76
3.7
3.9
51.27
58.42
%
0.81
11
67
11
67
1.66
0.76
3.7
3.5
3.00
4.45
e9/l
1.78
11
67
11
67
1.66
0.76
1.7
4.3
—
3.78
—
0
6
23
310
0.73
0.75
1.7
1.5
—
—
—
0
0
9
56
1.62
0.73
1.7
1.6
—
—
—
0
0
9
56
1.62
0.73
1.8
1.4
—
—
—
0
0
10
60
1.68
0.72
1.1
1.3
1.06
0.85
nmol/l
—
10
50
15
101
1.50
0.71
1.4
1.3
—
—
—
0
0
67
569
1.21
0.71
2.0
1.9
—
—
—
0
0
7
41
1.72
0.70
1.0
1.1
—
—
—
0
0
7
41
1.72
0.70
1.7
1.6
—
—
—
0
0
15
103
1.47
0.66
1.2
1.8
—
—
—
0
0
5
30
1.67
0.61
1.6
1.1
—
—
—
0
0
8
52
1.55
0.60
1.5
1.1
—
—
—
0
0
6
35
1.72
0.58
1.2
1.2
—
—
—
0
0
6
35
1.72
0.58
2.7
2.3
104.50
106.37
mmol/l
—
6
35
19
141
1.36
0.57
1.5
2.3
—
—
—
0
0
14
99
1.43
0.55
1.2
1.5
—
—
—
0
0
23
288
0.79
0.48
3.1
3.9
103.18
23.00
ug/l
0.35
17
233
28
227
1.25
0.48
1.4
1.3
—
—
—
0
0
5
31
1.62
0.43
1.6
2.1
—
16.63
—
0
10
5
32
1.57
0.42
19.8
11.6
789.40
826.25
nmol/l
—
5
32
5
32
1.57
0.42
20.8
16.0
1109.80
1621.28
nmol/l
—
5
32
5
33
1.52
0.41
1.8
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
15
114
1.33
0.41
1.3
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
6.7
—
35.80
—
0
5
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
17
0.00
0.40
0.0
2.2
—
116.06
—
0
17
0
17
0.00
0.40
0.0
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.3
—
—
—
0
0
15
116
1.30
0.37
1.3
1.1
—
—
—
0
0
13
100
1.31
0.34
1.4
1.1
—
—
—
0
0
61
554
1.12
0.31
2.7
3.6
57.79
253.54
ng/l
1.73
38
382
69
632
1.11
0.31
2.0
2.1
—
—
—
0
0
42
373
1.14
0.30
1.6
2.3
4.30
6.59
umol/l
2.06
36
322
5
40
1.25
0.22
1.8
1.7
—
—
—
0
0
16
135
1.19
0.21
2.0
2.0
—
—
—
0
0
5
42
1.19
0.21
2.0
1.4
—
—
—
0
0
5
42
1.19
0.21
2.2
1.4
—
—
—
0
0
5
42
1.19
0.21
2.2
1.4
—
—
—
0
0
5
42
1.19
0.21
1.8
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
9.64
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
12
98
1.23
0.21
1.6
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
1.8
1.4
—
—
—
0
0
5
43
1.16
0.21
1.8
1.4
—
—
—
0
0
6
48
1.25
0.20
1.7
1.5
—
—
—
0
0
6
48
1.25
0.20
1.7
1.5
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
14
0.00
0.20
0.0
1.0
—
135.21
—
0
14
42
385
1.10
0.20
3.3
2.7
0.60
0.72
ug/l
0.81
32
235
8
69
1.16
0.16
1.6
1.2
244.75
213.04
u/ml
—
8
41
16
139
1.16
0.16
1.5
1.5
—
—
—
0
0
9
82
1.10
0.15
1.6
1.2
—
—
—
0
0
7
89
0.78
0.14
1.3
1.6
—
—
—
0
0
13
113
1.16
0.13
1.4
1.2
—
—
—
0
0
81
781
1.05
0.11
1.5
1.5
—
—
—
0
0
5
65
0.77
0.08
1.0
1.5
—
—
—
0
0
6
74
0.81
0.07
2.7
2.8
—
—
—
0
0
8
74
1.08
0.07
1.5
1.1
—
—
—
0
0
17
158
1.08
0.06
1.4
1.5
—
—
—
0
0
15
161
0.93
0.05
2.3
1.8
—
—
—
0
0
22
215
1.02
0.00
1.8
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
3.6
—
132.13
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
22
220
1.00
-0.00
1.2
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
-0.00
1.0
1.1
—
—
—
0
0
5
58
0.86
-0.00
1.2
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
105.67
—
0
6
5
58
0.86
-0.00
1.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: E4_THYROTROPIN_DEFICIENCY – Thyrotropin deficiency
GWS hits: 1
This endpoint is excluded (different definition than used in FinnGen).