No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
508 |
4. Check minimum number of eventsNone |
508 |
5. Include endpointsNone |
508 |
6. Filter based on genotype QC (FinnGen only) |
497 |
Control definitions (FinnGen only)
- Control exclude
- G6_OTHNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G93
- Name in latin
- Laesio anoxica cerebri non alibi classificata
Similar endpoints
↥List of similar endpoints to
Anoxic brain damage
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7504 | 2213 | 5132 |
| Only index persons | 4082 | 1219 | 2863 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.06 | 0.14 |
| Only index persons | 0.09 | 0.04 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 60.56 | 61.03 | 60.15 |
| Only index persons | 60.34 | 60.12 | 60.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 497 | 131 | 366 |
| Unadjusted period prevalence (%) | 0.14 | 0.05 | 0.17 |
| Median age at first event (years) | 63.13 | 58.82 | 64.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 508
- Matched controls
- 5080
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
208.4
307.7
293
33
G93.1
ICD-10 Finland
Anoxic brain damage, not elsewhere classified
+∞
307.7
495
*
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
42.3
138.3
85
24
WX730
NOMESCO Finland
Conventional respirator
27.0
90.9
64
27
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.5
75.9
212
584
WX872
NOMESCO Finland
Intensive care
6.8
50.0
86
147
GBB00
NOMESCO Finland
Tracheostomy
17.8
42.2
35
21
XA800
NOMESCO Finland
Neuropsychological investigation
7.4
36.0
55
82
AA1AD
NOMESCO Finland
CT of head and brain
3.2
34.2
199
847
I47.2
ICD-10 Finland
Ventricular tachycardia
8.3
33.7
46
60
WX930
NOMESCO Finland
Thepapeutic hypothermia
70.4
29.3
33
5
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
8.4
28.9
39
50
N03AG01
ATC
valproic acid; systemic, rectal
5.3
27.4
59
123
I25.2
ICD-10 Finland
Old myocardial infarction
3.7
25.4
90
276
A98
ICPC
Health maint/preventive medicine
0.4
24.9
312
4125
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.6
22.3
195
990
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.7
21.4
53
124
N03AX14
ATC
levetiracetam; systemic
7.0
21.1
33
50
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
20.4
19.7
29
15
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
3.5
19.5
75
241
WX900
NOMESCO Finland
Resuscitation
48.0
19.3
23
5
Z2445
NOMESCO Finland
Psychologist
5.3
18.4
38
76
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.5
17.5
35
68
201
Kela drug reimbursment
Chronic cardiac insufficiency
3.6
17.4
62
189
AN1
HP
Coronary angiography
2.8
16.7
99
408
I46.9
ICD-10 Finland
Cardiac arrest, unspecified
18.7
16.6
25
14
C01BD01
ATC
amiodarone; systemic
5.4
16.2
33
65
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.3
16.1
168
901
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.4
15.8
60
191
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
6.3
15.7
27
45
3481A
ICD-9 Finland
Other conditions of brain, Anoxic brain damage
+∞
15.7
15
*
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.3
15.1
157
836
I42.0
ICD-10 Finland
Dilated cardiomyopathy
4.5
13.8
34
79
WX704
NOMESCO Finland
Intubation
3.3
13.8
54
175
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
3.7
13.7
45
130
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.5
13.5
49
151
ZXD00
NOMESCO Finland
Emergency procedure
4.8
13.2
30
65
Z02.4
ICD-10 Finland
Examination for driving licence
0.3
13.1
42
1149
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.1
12.9
58
204
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
14.5
12.9
21
15
R4150
NOMESCO Finland
Neuropsychological rehabilitation
16.0
12.7
20
13
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
5.8
12.5
23
41
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
12.3
79
336
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.6
12.2
41
120
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.0
12.1
55
195
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.3
12.0
31
75
W79
ICD-10 Finland
Inhalation and ingestion of food causing obstruction of respiratory tract
30.8
11.7
15
5
WX882
NOMESCO Finland
High dependency care
4.5
11.6
29
68
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
15.5
11.4
18
12
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
11.5
11.1
20
18
ZXD05
NOMESCO Finland
Urgent procedure
2.0
11.1
172
1046
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
5.9
11.1
20
35
N18
ICPC
Paralysis/weakness
5.6
11.0
21
39
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
10.8
171
1048
I21.01
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
5.4
10.7
21
40
FPJ21
NOMESCO Finland
Revision of cardioverter-defibrillator with ventricular electrode
61.3
10.7
12
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.7
10.5
60
241
T71
ICD-10 Finland
Asphyxiation
+∞
10.4
10
*
B01AA03
ATC
warfarin; systemic
2.0
10.4
140
808
I21.00
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
5.3
10.4
21
41
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.1
10.0
122
678
OAA67, ,
SPAT
0.0
10.0
*
275
C03CA01
ATC
furosemide; systemic
1.9
9.9
197
1291
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.6
9.9
63
267
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.8
9.7
52
201
C09AA05
ATC
ramipril; oral
1.9
9.5
157
968
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.2
9.4
37
120
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
+∞
9.4
9
*
FPG40
NOMESCO Finland
Replacement of pulse generator in transvenous cardioverter-defibrillator
22.2
9.4
13
6
AS7
HP
Arrhythmia pacemaker insertion VVI (R) S
22.2
9.4
13
6
M01AH05
ATC
etoricoxib; oral
0.5
9.1
138
2096
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.4
9.0
65
291
L89
ICD-10 Finland
Decubitus ulcer and pressure area
5.0
8.9
19
39
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.2
8.8
77
376
G41.9
ICD-10 Finland
Status epilepticus, unspecified
16.6
8.6
13
8
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
10.3
8.6
16
16
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.3
8.5
33
106
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.0
8.5
38
133
C07AB07
ATC
bisoprolol; oral
1.7
8.5
265
1961
G93.0
ICD-10 Finland
Cerebral cysts
+∞
8.4
8
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
6.7
8.3
20
31
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
8.2
305
3678
205
Kela drug reimbursment
Chronic hypertension
1.8
8.1
160
1034
N05AH03
ATC
olanzapine; systemic
3.0
8.0
35
121
N03AE01
ATC
clonazepam; systemic
3.0
7.9
35
122
K90
ICPC
Stroke/cerebrovascular accident
3.7
7.7
24
67
JDB10
NOMESCO Finland
Percutaneous gastrostomy
6.6
7.5
18
28
N05AA02
ATC
levomepromazine; systemic
3.3
7.4
28
89
N05BA09
ATC
clobazam; oral
16.0
7.3
11
7
N29
ICPC
Neurological sympt/complt other
6.2
7.1
18
30
I50.0
ICD-10 Finland
Congestive heart failure
2.2
7.0
60
289
R55
ICD-10 Finland
Syncope and collapse
2.2
7.0
65
324
OAB43, ,
SPAT
0.3
7.0
18
572
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
6.0
7.0
18
31
I34.1
ICD-10 Finland
Mitral (valve) prolapse
3.7
6.9
22
62
C09AA02
ATC
enalapril; systemic
1.8
6.8
113
689
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.8
6.8
130
827
N02BE01
ATC
paracetamol; systemic, rectal
0.6
6.8
318
3738
FXF00
NOMESCO Finland
Decannulation after ECHLA or ECLA
40.6
6.8
8
*
X70
ICD-10 Finland
Intentional self-harm by hanging, strangulation and suffocation
22.9
6.7
9
*
WX890
NOMESCO Finland
Intesive care monitoring
8.0
6.7
14
18
R40.2
ICD-10 Finland
Coma, unspecified
8.0
6.7
14
18
I50.1
ICD-10 Finland
Left ventricular failure
2.5
6.6
41
171
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.1
6.5
27
91
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
2.4
6.4
43
186
Z43.0
ICD-10 Finland
Attention to tracheostomy
70.7
6.4
7
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
4.2
6.4
17
42
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
11.2
6.3
11
10
F06.9
ICD-10 Finland
Unspecified mental disorder due to brain damage and dysfunction and to physical disease
18.3
6.3
9
5
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
6.3
6
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.4
6.3
44
195
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
6.3
104
634
XA400
NOMESCO Finland
EEG
12.7
6.1
10
8
C08DB01
ATC
diltiazem; oral
2.6
6.1
36
147
81
HP
Angiography of the heart and coronary arteries
2.2
6.0
51
245
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
109
375
3.43
25.86
8.6
8.1
8.87
10.78
mmol/l
1.87
102
354
323
4206
0.36
24.95
34.7
22.9
131.03
136.17
g/l
6.03
317
4127
323
4204
0.36
24.82
34.4
22.8
4.33
4.50
e12/l
6.67
310
4066
323
4202
0.36
24.68
34.5
22.8
233.14
238.91
e9/l
0.80
309
4082
323
4201
0.37
24.62
36.9
23.0
38.56
40.22
%
3.22
288
3913
277
3752
0.42
19.49
5.4
5.0
2.40
2.66
mmol/l
4.81
254
3406
265
3638
0.43
18.87
4.8
4.5
1.36
1.38
mmol/l
0.40
246
3308
315
4015
0.43
17.50
13.4
10.8
35.14
27.22
u/l
1.57
303
3867
273
3670
0.45
17.38
5.0
4.5
4.24
4.49
mmol/l
2.94
251
3369
260
3550
0.45
17.02
20.0
14.9
81.07
78.38
ml/min/173m2
0.86
220
2969
273
3651
0.45
16.61
4.9
4.6
6.20
6.06
mmol/l
0.52
245
3283
259
3513
0.46
15.93
6.6
6.0
41.02
40.68
mmol/mol
0.21
244
3234
263
3537
0.47
15.53
4.6
4.0
1.35
1.30
mmol/l
0.43
242
3199
106
480
2.53
14.67
15.5
8.8
5.24
5.14
kpa
0.36
100
452
106
480
2.53
14.67
15.0
8.8
0.44
1.28
mmol/l
0.91
82
375
106
480
2.53
14.67
15.5
8.8
13.66
11.41
kpa
1.89
99
455
127
640
2.31
13.79
5.6
3.6
0.85
0.82
mmol/l
0.81
119
595
38
97
4.15
13.68
1.8
3.9
36.27
35.45
umol/l
0.05
33
85
110
529
2.38
13.25
7.0
6.3
1.11
1.04
mmol/l
1.39
103
485
320
3944
0.49
12.69
32.6
18.6
4.01
4.01
mmol/l
0.12
311
3823
321
3932
0.50
11.93
33.2
18.4
138.88
139.67
mmol/l
3.69
315
3816
54
1238
0.37
11.43
3.0
3.1
0.66
0.81
ug/l
0.91
42
826
135
2131
0.50
10.63
3.9
5.1
2.09
3.72
ug/l
1.99
115
1876
138
2150
0.51
10.32
2.7
2.8
—
—
—
0
0
259
3336
0.54
10.21
5.2
4.2
2.21
2.01
mu/l
0.69
237
2978
77
367
2.29
9.30
3.3
2.6
24.91
7.52
ug/l
2.11
71
323
206
2796
0.56
9.24
4.1
4.0
13.98
13.07
mm/h
0.29
195
2548
317
3812
0.55
9.06
24.3
15.7
31.52
26.79
mg/l
1.59
275
3082
103
1707
0.50
8.89
4.1
4.3
22.19
21.39
%
0.21
46
836
47
189
2.64
8.16
2.4
2.0
0.98
1.65
ug/l
0.60
41
166
259
3249
0.59
7.97
26.6
18.7
15.25
15.16
%
0.09
259
3192
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
39
146
2.81
7.77
3.5
2.5
0.34
0.32
u/ml
0.27
25
84
253
1920
1.63
6.81
24.1
18.0
1.40
1.35
inr
0.23
72
542
17
31
5.64
6.35
1.4
1.5
1.33
1.20
promille
0.11
12
23
5
275
0.17
6.26
1.4
1.8
—
—
—
0
0
160
1109
1.65
6.02
2.7
2.2
354.20
343.24
u/l
0.04
149
1040
56
285
2.08
5.72
2.0
1.6
—
—
—
0
0
63
369
1.81
4.28
5.1
2.9
226.54
241.85
ng/l
0.13
58
334
9
14
6.52
4.00
3.1
4.8
87.67
110.71
%
—
9
14
73
1079
0.62
3.48
3.1
2.9
13358.31
6657.91
umol/l
0.33
61
929
138
1783
0.69
3.40
5.6
5.0
0.00
0.00
estimate
-0.00
27
353
142
1808
0.70
3.16
4.3
3.6
0.00
0.00
estimate
0.50
29
377
143
1811
0.71
3.06
4.3
3.6
0.00
0.01
estimate
0.50
27
330
125
1608
0.70
2.90
2.3
2.0
98.71
92.47
pmol/l
0.76
68
883
31
547
0.54
2.89
1.3
1.3
19.15
38.42
iu/ml
—
10
175
226
2638
0.74
2.79
4.2
3.5
14.93
14.80
pmol/l
0.26
204
2346
31
541
0.55
2.78
1.3
1.2
1.40
10.71
u/ml
2.77
12
213
47
728
0.61
2.70
2.9
2.8
1.25
0.95
e6/l
0.19
28
448
28
496
0.54
2.65
4.4
4.5
34.45
31.22
%
0.72
22
334
32
541
0.56
2.58
1.6
1.4
—
—
—
0
0
263
2980
0.76
2.50
9.0
8.0
87.24
81.23
u/l
0.65
254
2797
70
977
0.67
2.49
1.8
1.7
1.42
1.39
mmol/l
0.11
64
811
212
2470
0.76
2.45
4.4
3.3
80.29
54.70
u/l
1.93
187
2298
72
995
0.68
2.43
1.5
1.5
22.38
19.79
nmol/l
0.64
62
845
216
2500
0.76
2.33
4.8
4.3
127.60
1948.50
e6/l
—
5
46
46
692
0.63
2.33
3.0
3.0
1.11
1.37
e6/l
0.27
27
415
59
403
1.52
2.28
8.3
4.2
1.33
1.98
mmol/l
0.93
45
329
101
766
1.40
2.27
6.3
3.7
3268.46
320.52
ng/l
1.14
90
623
90
1178
0.71
2.23
3.5
3.2
1.32
0.62
e6/l
0.57
75
911
50
722
0.66
2.10
1.3
1.3
0.66
1.62
u/ml
—
9
184
10
233
0.42
2.09
2.2
2.4
—
19.32
—
0
12
58
404
1.49
2.05
8.4
4.1
5.70
5.87
kpa
0.61
52
391
29
170
1.75
2.05
3.6
3.4
4.10
4.54
pmol/l
1.27
23
147
187
1582
1.29
1.99
4.8
3.8
103.88
48.58
ng/l
2.31
159
1163
7
21
3.36
1.97
1.6
1.0
2.17
1.84
mmol/l
—
7
21
189
2191
0.78
1.94
9.5
9.4
4.62
4.20
e9/l
1.64
172
1929
13
60
2.20
1.79
3.5
1.8
145.93
368.66
u/l
—
6
17
156
1307
1.28
1.76
4.5
3.1
2608.32
1850.37
ng/l
0.82
146
1125
116
1416
0.77
1.76
4.4
3.8
—
—
—
0
0
54
740
0.70
1.73
4.9
3.3
2.44
2.45
mmol/l
0.07
42
647
154
1809
0.79
1.71
6.8
5.8
60.62
57.93
%
1.79
145
1707
157
1838
0.79
1.69
7.0
6.1
23.42
26.68
%
2.73
149
1729
104
1281
0.76
1.68
3.6
3.4
69.92
143.24
e6/l
0.66
84
1009
10
212
0.46
1.68
1.1
1.3
—
75.99
—
0
14
147
1230
1.27
1.67
3.4
2.6
73.61
60.31
u/l
0.43
138
1141
134
1597
0.78
1.67
3.4
2.8
169.22
161.76
ug/l
0.13
118
1460
52
378
1.42
1.52
2.9
2.5
0.21
0.20
g/l
0.22
46
348
7
27
2.61
1.52
1.4
1.8
—
—
—
0
0
9
37
2.46
1.48
2.1
2.8
—
—
—
0
0
9
43
2.11
1.31
1.1
1.2
—
—
—
0
0
144
1247
1.22
1.18
3.8
3.6
143.00
33.93
u/l
0.84
136
1182
228
2062
1.19
1.17
7.3
6.8
13.35
12.15
umol/l
0.26
218
1955
13
72
1.83
1.16
1.5
1.2
430.38
468.07
mg/l
0.19
13
67
129
1490
0.82
1.16
3.5
3.2
—
—
—
0
0
19
119
1.62
1.13
1.4
1.2
—
—
—
0
0
86
708
1.26
1.12
2.0
1.9
—
—
—
0
0
5
21
2.39
1.09
1.4
1.9
—
—
—
0
0
110
1283
0.82
1.08
3.2
3.3
7.62
8.07
mmol/l
0.39
92
1065
26
178
1.49
1.07
1.8
2.0
—
—
—
0
0
111
1289
0.82
1.04
3.5
3.9
14.75
11.21
mg/mmol
0.23
83
871
5
22
2.28
1.03
1.4
1.9
—
—
—
0
0
13
76
1.73
0.99
2.4
3.3
5.20
4.69
e9/l
0.17
13
76
127
1449
0.84
0.99
2.3
2.2
70.92
75.95
nmol/l
1.37
110
1291
9
50
1.81
0.97
1.3
1.8
—
—
—
0
0
0
31
0.00
0.96
0.0
1.2
—
—
—
0
0
7
130
0.53
0.89
1.9
1.7
46.71
40.66
nmol/l
—
7
123
13
79
1.66
0.88
2.6
3.9
60.46
57.81
%
0.27
13
79
11
64
1.73
0.86
1.3
1.2
1.73
9.04
e6/l
0.96
11
51
11
64
1.73
0.86
1.4
1.1
3.82
3.68
mmol/l
0.16
11
59
11
64
1.73
0.86
1.4
1.4
13.45
1801.17
e6/l
0.55
11
53
44
347
1.29
0.83
9.8
3.1
4.84
4.48
kpa
0.47
38
334
8
46
1.75
0.83
1.3
1.6
—
—
—
0
0
8
46
1.75
0.83
1.3
1.6
—
—
—
0
0
16
105
1.54
0.82
1.3
1.7
—
—
—
0
0
23
164
1.42
0.81
1.9
1.8
—
—
—
0
0
186
1696
1.15
0.81
6.9
5.2
32.83
35.14
g/l
4.19
167
1583
10
58
1.74
0.80
1.5
1.7
—
—
—
0
0
249
2320
1.14
0.79
11.5
5.2
7.20
6.88
mmol/l
0.91
238
2176
33
252
1.33
0.79
1.8
1.4
—
—
—
0
0
5
98
0.51
0.78
1.2
1.5
—
—
—
0
0
10
59
1.71
0.76
1.5
1.7
—
—
—
0
0
11
67
1.66
0.75
1.2
1.7
—
—
—
0
0
11
67
1.66
0.75
1.2
1.7
—
—
—
0
0
5
92
0.54
0.67
3.6
1.8
234.00
231.13
pmol/l
—
5
85
11
70
1.58
0.65
1.5
1.7
—
—
—
0
0
15
103
1.47
0.65
1.3
1.7
—
—
—
0
0
5
29
1.73
0.64
1.2
1.6
113.20
87.79
umol/l
—
5
29
90
792
1.17
0.63
1.7
1.7
1209.22
1119.61
nmol/l
0.49
70
602
50
418
1.22
0.61
2.2
1.9
1.82
1.55
%
1.03
43
361
58
493
1.20
0.61
2.0
1.8
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
159.50
—
0
21
14
97
1.46
0.59
2.9
2.0
119.11
129.64
g/l
—
9
69
0
23
0.00
0.58
0.0
3.3
—
84.57
—
0
23
7
116
0.60
0.58
1.6
1.8
—
—
—
0
0
86
967
0.87
0.57
4.3
3.8
0.00
0.01
estimate
0.50
26
330
58
497
1.19
0.56
2.0
1.8
—
—
—
0
0
10
65
1.55
0.56
2.0
3.4
—
972.83
—
0
6
22
169
1.32
0.54
2.5
3.0
—
—
—
0
0
51
435
1.19
0.53
6.4
3.7
—
—
—
0
0
10
146
0.68
0.53
3.1
3.4
—
—
—
0
0
24
303
0.78
0.52
1.5
1.4
—
—
—
0
0
71
804
0.86
0.52
5.3
3.8
1.01
1.02
kg/l
0.61
14
115
205
1928
1.11
0.51
13.7
7.3
1.18
1.21
mmol/l
4.35
173
1630
7
45
1.56
0.49
1.0
2.0
—
—
—
0
0
36
300
1.22
0.48
7.7
3.9
2.92
1.93
mmol/l
0.91
26
223
186
1746
1.10
0.48
15.9
6.5
1.18
1.21
mmol/l
5.58
174
1585
10
68
1.48
0.47
1.3
1.5
—
—
—
0
0
12
165
0.72
0.47
1.1
1.0
—
—
—
0
0
93
845
1.12
0.43
1.6
1.8
433.17
8108521.00
pmol/l
0.50
78
703
6
91
0.66
0.42
1.5
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
8.08
—
0
16
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
35
297
1.19
0.40
2.9
3.1
65.09
62.54
ml/min/173m2
0.21
22
127
37
316
1.18
0.40
5.1
3.8
1.20
1.22
mmol/l
1.40
31
280
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
2.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
7
102
0.68
0.40
1.1
1.2
—
—
—
0
0
7
102
0.68
0.40
1.1
1.2
—
—
—
0
0
44
504
0.86
0.39
2.2
3.9
363.13
254.96
u/l
1.28
39
469
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
11
80
1.38
0.38
1.3
1.8
—
—
—
0
0
6
42
1.43
0.35
1.0
2.1
—
—
—
0
0
16
128
1.26
0.32
1.4
2.1
—
—
—
0
0
38
431
0.87
0.31
2.9
4.7
15.33
36.46
ug/l
0.49
31
360
7
54
1.30
0.30
1.4
1.7
—
—
—
0
0
8
106
0.75
0.29
1.3
1.6
—
—
—
0
0
30
261
1.16
0.28
1.6
1.9
—
—
—
0
0
9
116
0.77
0.27
2.1
1.4
—
—
—
0
0
8
65
1.23
0.27
5.4
3.0
105.88
105.60
mmol/l
—
8
65
122
1285
0.93
0.25
4.1
3.6
2.34
2.34
mmol/l
0.00
111
1128
13
105
1.24
0.25
1.4
2.0
—
—
—
0
0
11
87
1.27
0.24
1.5
1.4
—
—
—
0
0
5
38
1.32
0.23
1.0
1.8
—
—
—
0
0
5
38
1.32
0.23
2.4
2.2
—
—
—
0
0
5
38
1.32
0.23
1.6
1.6
—
—
—
0
0
5
38
1.32
0.23
1.0
1.8
—
—
—
0
0
5
38
1.32
0.23
1.0
1.8
—
—
—
0
0
13
157
0.82
0.22
1.2
1.3
—
—
—
0
0
5
42
1.19
0.21
1.2
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
7.90
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
99
939
1.07
0.21
3.0
2.4
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
66
617
1.08
0.20
3.5
2.4
2.31
2.26
g/l
0.29
57
571
13
109
1.20
0.18
1.5
1.3
—
—
—
0
0
6
78
0.77
0.15
1.0
1.3
—
—
—
0
0
25
275
0.90
0.15
1.6
1.6
—
—
—
0
0
11
129
0.85
0.15
3.5
4.4
48.50
118.35
mg/l
—
6
104
11
93
1.19
0.14
1.0
1.1
—
2.99
—
0
9
34
367
0.92
0.14
2.5
2.5
36.70
34.34
u/l
0.18
27
312
31
286
1.09
0.13
1.7
1.9
—
—
—
0
0
184
1798
1.04
0.13
3.1
2.7
—
—
—
0
0
11
127
0.86
0.12
3.2
4.3
—
2.50
—
0
12
103
1064
0.96
0.12
2.7
2.1
3.24
3.08
mg/l
0.25
83
901
61
583
1.05
0.11
3.8
2.5
20.29
22.94
%
0.88
49
495
85
821
1.04
0.10
2.1
1.7
2.34
1.43
mg/l
1.19
69
640
22
203
1.09
0.09
10.2
2.7
0.67
0.65
%
0.19
22
203
45
471
0.95
0.09
12.4
7.0
—
—
—
0
0
6
55
1.09
0.09
1.8
1.5
—
—
—
0
0
6
56
1.07
0.08
1.8
1.5
—
—
—
0
0
6
57
1.05
0.08
1.8
1.5
—
—
—
0
0
6
57
1.05
0.08
1.8
1.5
—
—
—
0
0
6
57
1.05
0.08
1.8
1.5
—
—
—
0
0
6
57
1.05
0.08
1.8
1.5
—
—
—
0
0
6
58
1.03
0.08
1.0
1.2
—
—
—
0
0
5
65
0.77
0.08
1.2
1.4
—
—
—
0
0
7
68
1.03
0.08
1.0
1.1
—
—
—
0
0
65
671
0.96
0.07
3.6
2.5
11.61
12.71
umol/l
0.72
58
623
7
85
0.82
0.07
1.6
1.4
—
—
—
0
0
9
104
0.86
0.06
4.2
2.2
—
—
—
0
0
10
95
1.05
0.00
1.0
1.3
—
—
—
0
0
12
116
1.04
0.00
1.8
1.6
—
—
—
0
0
18
181
0.99
0.00
1.2
1.2
107.73
167.28
iu/ml
—
7
58
48
481
1.00
0.00
3.1
3.3
7.34
8.45
umol/l
0.39
39
431
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
21.56
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
89
0.90
-0.00
1.5
1.3
—
—
—
0
0
8
89
0.90
-0.00
1.5
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.4
—
31.20
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.0
—
—
—
0
0
7
79
0.88
-0.00
2.4
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_ANOXBRAINDAM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ANOXBRAINDAM | 5.632 [4.28, 7.42] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.638 |
During the follow-up period (1.1.1998 — 31.12.2019), 257 out of 594 females with G6_ANOXBRAINDAM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ANOXBRAINDAM | 4.447 [3.79, 5.22] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 781 out of 1580 males with G6_ANOXBRAINDAM died.
Mortality risk
Mortality risk for people of age
years, who have G6_ANOXBRAINDAM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.472% | 1.023% |
| 5 | 3.401% | 5.482% |
| 10 | 9.156% | 13.608% |
| 15 | 16.581% | 24.711% |
| 20 | 27.016% | 40.035% |
Relationships between endpoints
↥Index endpoint: G6_ANOXBRAINDAM – Anoxic brain damage
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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