mononeuropathy: Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
276 |
4. Check minimum number of eventsNone |
276 |
5. Include endpointsNone |
276 |
6. Filter based on genotype QC (FinnGen only) |
276 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G58
- Name in latin
- Neuropathia intercostalis
Similar endpoints
↥List of similar endpoints to
Intercostal neuropathy
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1814 | 986 | 815 |
| Only index persons | 1687 | 950 | 737 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 55.78 | 56.59 | 54.97 |
| Only index persons | 55.47 | 56.25 | 54.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 276 | 150 | 126 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.06 |
| Median age at first event (years) | 56.87 | 54.84 | 59.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 254
- Matched controls
- 2540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G58.0
ICD-10 Finland
Intercostal neuropathy
+∞
323.0
254
*
N03AX12
ATC
gabapentin; oral
13.2
62.3
125
173
N03AX16
ATC
pregabalin; oral
9.8
57.7
150
326
N02AX02
ATC
tramadol; systemic, rectal
8.3
50.6
195
725
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
8.5
36.3
89
152
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.9
30.7
147
558
N06AA09
ATC
amitriptyline; systemic
8.3
30.0
72
115
N06AX21
ATC
duloxetine; oral
6.9
24.0
65
121
G56.0
ICD-10 Finland
Carpal tunnel syndrome
14.7
22.0
37
29
R52.2
ICD-10 Finland
Other chronic pain
11.8
19.9
37
36
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
41.9
18.9
23
6
M25.5
ICD-10 Finland
Pain in joint
3.8
18.9
101
378
R07.4
ICD-10 Finland
Chest pain, unspecified
3.6
17.8
105
419
M79.6
ICD-10 Finland
Pain in limb
3.3
17.1
118
529
R10.1
ICD-10 Finland
Pain localized to upper abdomen
4.1
16.6
74
233
N02AA05
ATC
oxycodone; systemic
4.2
16.0
68
204
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.6
15.4
84
307
A02BC02
ATC
pantoprazole; systemic
3.1
15.0
190
1241
A02BC03
ATC
lansoprazole; oral
3.1
14.6
100
434
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
14.6
14.5
24
18
N06AA10
ATC
nortriptyline; systemic
20.7
14.5
21
11
M79.1
ICD-10 Finland
Myalgia
4.5
14.4
55
148
M54.5
ICD-10 Finland
Low back pain
3.0
14.4
109
504
M54.6
ICD-10 Finland
Pain in thoracic spine
5.9
14.3
41
80
M54.4
ICD-10 Finland
Lumbago with sciatica
4.0
14.3
62
188
R07.3
ICD-10 Finland
Other chest pain
5.0
14.0
47
110
M03BX02
ATC
tizanidine; oral
2.9
13.6
178
1143
R52.9
ICD-10 Finland
Pain, unspecified
5.2
13.6
44
99
A02BC05
ATC
esomeprazole; systemic
2.7
13.2
135
742
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
4.1
13.0
54
156
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
13.0
140
795
N03AF01
ATC
carbamazepine; oral, rectal
7.8
12.7
29
41
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
12.7
99
458
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
3.2
12.5
75
292
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
39.7
12.3
15
*
N03AX09
ATC
lamotrigine; oral
7.0
11.8
29
46
Z50.1
ICD-10 Finland
Other physical therapy
6.4
11.8
31
54
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.6
11.8
135
775
A06AD11
ATC
lactulose; oral
3.6
11.8
58
194
ACC51
NOMESCO Finland
Release of median nerve
125.5
11.5
12
*
A02BC01
ATC
omeprazole; systemic
2.7
11.5
97
467
R06.0
ICD-10 Finland
Dyspnoea
2.9
11.5
86
384
M54.3
ICD-10 Finland
Sciatica
6.4
11.5
30
52
Z01.8
ICD-10 Finland
Other specified special examinations
3.0
11.2
75
312
R51.80
ICD-10 Finland
Headache
3.6
11.0
53
173
G50.0
ICD-10 Finland
Trigeminal neuralgia
45.4
11.0
13
*
J45.9
ICD-10 Finland
Asthma, unspecified
3.1
10.6
63
241
G58.9
ICD-10 Finland
Mononeuropathy, unspecified
+∞
10.5
10
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.2
10.2
39
104
G44.2
ICD-10 Finland
Tension-type headache
3.6
10.2
48
154
M01AB05
ATC
diclofenac; systemic, rectal
2.5
10.2
182
1281
N02AJ06
ATC
codeine and paracetamol; systemic
2.5
10.2
113
624
N02BE01
ATC
paracetamol; systemic, rectal
3.4
10.1
229
1849
N06AX16
ATC
venlafaxine; oral
3.4
10.1
51
173
M03BC01
ATC
orphenadrine (citrate); systemic
2.8
10.0
76
339
A01
ICPC
Pain general/multiple sites
4.6
9.9
35
86
TAC99
NOMESCO Finland
Other blockade for chronic pain
27.3
9.9
13
5
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.6
9.8
88
432
J01MA14
ATC
moxifloxacin; systemic
4.3
9.7
36
93
N06AX11
ATC
mirtazapine; oral
2.5
9.6
97
507
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.9
9.4
63
259
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
5.8
9.4
26
49
J01MA12
ATC
levofloxacin; systemic
2.8
9.3
66
282
M01AH05
ATC
etoricoxib; oral
2.3
9.2
158
1064
N03AF02
ATC
oxcarbazepine; oral
6.6
8.8
22
36
TAC00
NOMESCO Finland
Peripheral nerve block
51.8
8.7
10
*
M54.9
ICD-10 Finland
Dorsalgia, unspecified
3.4
8.6
43
144
L05
ICPC
Flank/axilla symptom/complaint
5.0
8.6
27
59
L01
ICPC
Neck symptom/complaint
3.2
8.6
47
167
N05CF01
ATC
zopiclone; oral
2.3
8.5
97
532
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
9.0
8.4
17
20
G47.3
ICD-10 Finland
Sleep apnoea
2.6
8.4
70
324
J01FF01
ATC
clindamycin; systemic
2.4
8.4
83
424
N03AE01
ATC
clonazepam; systemic
5.1
8.4
26
56
L13
ICPC
Hip symptom/complaint
3.0
8.3
51
198
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
9.4
8.2
16
18
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
8.0
84
441
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.3
8.0
40
135
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
5.4
7.9
23
46
R03AC02
ATC
salbutamol; inhalant
2.1
7.9
145
974
H02AB06
ATC
prednisolone; systemic
2.1
7.9
128
817
M01AX17
ATC
nimesulide; oral
2.4
7.9
74
367
M70.6
ICD-10 Finland
Trochanteric bursitis
3.4
7.7
37
120
R52.0
ICD-10 Finland
Acute pain
7.1
7.7
18
27
R52.1
ICD-10 Finland
Chronic intractable pain
25.9
7.6
10
*
K30
ICD-10 Finland
Functional dyspepsia
3.3
7.5
37
123
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.9
7.4
30
85
M01AB55
ATC
diclofenac, combinations; oral
4.0
7.4
29
80
TAC02
NOMESCO Finland
Block of intercostal nerve
+∞
7.3
7
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.8
7.3
30
86
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
7.3
51
213
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.6
7.2
56
247
S22.3
ICD-10 Finland
Fracture of rib
3.8
7.2
30
87
P01AB01
ATC
metronidazole; oral, rectal
2.1
7.2
109
667
WX110
NOMESCO Finland
Local anesthesy
2.1
7.2
183
1387
J01MA02
ATC
ciprofloxacin; systemic
2.1
7.2
112
696
G56.2
ICD-10 Finland
Lesion of ulnar nerve
31.0
7.2
9
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
7.2
113
703
C07AB07
ATC
bisoprolol; oral
2.1
7.2
131
867
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.9
7.1
22
48
M53.1
ICD-10 Finland
Cervicobrachial syndrome
3.4
7.1
34
111
M03BC51
ATC
orphenadrine, combinations; systemic
2.2
7.0
80
432
R42
ICD-10 Finland
Dizziness and giddiness
2.4
7.0
66
323
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.1
7.0
110
682
B02
ICD-10 Finland
Zoster [herpes zoster]
7.0
6.9
16
24
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
6.9
70
358
SPAT1153
SPAT
Removal of sutures
2.2
6.9
92
530
L28
ICPC
Limited function/disability (L)
2.7
6.9
49
207
M48.0
ICD-10 Finland
Spinal stenosis
2.9
6.9
42
160
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.6
6.9
30
91
N05AH04
ATC
quetiapine; oral
2.6
6.8
52
229
UJF32
NOMESCO Finland
Coloscopy
2.3
6.8
73
381
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
6.8
137
935
M01AH02
ATC
rofecoxib; oral
2.8
6.8
45
181
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
5.8
6.7
18
33
J02AC01
ATC
fluconazole; systemic
2.1
6.7
103
628
R02
ICPC
Shortness of breath/dyspnoea
2.9
6.6
41
160
XF404
NOMESCO Finland
Ambulatory ECG
3.2
6.5
33
112
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
7.7
6.5
14
19
G58.8
ICD-10 Finland
Other specified mononeuropathies
71.6
6.5
7
*
M79.5
ICD-10 Finland
Residual foreign body in soft tissue
14.8
6.4
10
7
M01AH03
ATC
valdecoxib; oral
3.8
6.4
26
74
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.9
6.4
25
69
M01AH01
ATC
celecoxib; oral (coxibs)
2.4
6.4
57
273
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
3.2
6.4
33
114
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.3
6.3
64
325
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.1
6.3
90
534
G54.9
ICD-10 Finland
Nerve root and plexus disorder, unspecified
+∞
6.3
6
*
WX250
NOMESCO Finland
Intercostal blockade
27.4
6.3
8
*
A02BA04
ATC
nizatidine; systemic
3.5
6.2
28
87
N02AC04
ATC
dextropropoxyphene; oral
4.9
6.2
19
41
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.0
6.2
36
134
Z71.8
ICD-10 Finland
Other specified counselling
2.2
6.2
69
365
H66.0
ICD-10 Finland
Acute suppurative otitis media
4.4
6.2
21
51
A02BA02
ATC
ranitidine; systemic
2.3
6.2
61
304
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.6
6.1
46
201
Z02.7
ICD-10 Finland
Issue of medical certificate
4.0
6.1
23
62
N05BA01
ATC
diazepam; systemic, rectal
2.7
6.1
44
186
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
6.0
62
315
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
136
672
3.02
18.11
3.1
2.6
51.8
55.8
u/l
1.00
127
619
213
1487
2.89
12.77
5.5
4.3
41.0
541.6
e6/l
—
6
25
100
494
2.61
12.35
1.8
1.7
1.0
1.4
mg/l
1.43
77
382
179
1163
2.53
12.16
6.7
6.7
11.0
11.7
umol/l
0.20
174
1104
192
1291
2.60
12.09
9.0
9.1
4.4
4.2
e9/l
0.40
166
1134
193
1302
2.60
12.05
6.0
5.0
6.6
6.6
mmol/l
0.04
188
1212
136
800
2.38
11.26
3.6
3.1
—
—
—
0
0
229
1724
2.93
10.73
9.6
7.5
75.4
77.3
u/l
0.39
219
1597
148
926
2.29
10.34
4.4
4.9
35.6
35.6
g/l
0.05
142
865
166
1091
2.31
10.29
4.1
3.4
0.0
0.0
estimate
0.00
47
207
167
1110
2.28
9.94
7.5
7.0
1.2
1.2
mmol/l
0.34
133
942
166
1101
2.27
9.93
5.4
4.8
0.0
0.0
estimate
0.00
47
204
75
360
2.49
9.52
3.9
3.6
0.8
0.8
mmol/l
0.98
69
340
111
639
2.23
9.23
3.6
3.0
0.1
0.6
e6/l
3.14
86
479
165
1115
2.19
9.12
4.1
3.5
0.1
0.0
estimate
0.49
42
198
218
1655
2.51
9.06
5.4
3.8
12.2
11.7
mm/h
0.16
206
1498
85
441
2.34
9.03
5.2
3.6
37.2
218.7
ng/l
2.00
61
358
142
914
2.14
8.79
2.3
2.1
75.4
78.3
nmol/l
0.52
130
796
118
714
2.14
8.51
3.4
3.2
28.5
30.4
u/l
0.51
111
677
132
850
2.06
7.92
4.3
3.7
—
—
—
0
0
100
585
2.11
7.73
4.5
3.8
0.0
0.0
estimate
0.00
46
204
121
761
2.05
7.69
2.6
3.4
2.4
2.4
mmol/l
0.17
107
657
54
247
2.47
7.47
2.4
1.8
—
—
—
0
0
19
48
4.18
7.01
3.3
2.3
16.3
16.3
%
—
10
22
147
1016
1.96
6.92
7.0
6.2
1.2
1.2
mmol/l
0.23
132
911
69
363
2.20
6.89
2.3
1.8
—
—
—
0
0
129
854
1.96
6.89
6.2
3.5
21.7
37.0
ng/l
1.51
103
590
104
639
2.01
6.89
2.7
2.2
152.8
202.5
u/l
0.60
97
601
14
29
5.03
6.52
3.1
2.3
4.2
4.7
e9/l
0.23
14
29
51
244
2.34
6.35
2.3
1.8
—
—
—
0
0
65
352
2.11
5.97
1.3
1.2
29.3
29.7
iu/ml
0.01
16
108
48
230
2.32
5.94
5.5
3.3
—
—
—
0
0
93
575
1.93
5.89
2.6
2.6
344.0
8504.9
umol/l
2.86
80
504
14
32
4.56
5.83
3.9
2.9
59.9
57.6
%
0.22
14
32
11
21
5.41
5.57
1.5
1.4
—
—
—
0
0
61
331
2.08
5.54
1.3
1.3
1.6
9.8
u/ml
1.82
20
127
41
189
2.37
5.53
4.3
3.6
1.2
1.2
mmol/l
0.13
35
170
84
514
1.91
5.43
2.6
1.9
2.8
3.0
mg/l
0.40
78
436
75
442
1.96
5.41
4.1
3.8
1.0
1.0
kg/l
0.76
18
54
34
147
2.50
5.26
2.4
1.6
—
—
—
0
0
38
174
2.37
5.20
4.1
2.8
95.3
209.4
ng/l
3.43
33
162
44
218
2.21
5.02
2.6
2.6
27.8
29.2
u/l
0.16
37
189
30
125
2.57
5.00
3.2
3.2
2.5
1.9
mmol/l
0.52
22
95
28
113
2.64
4.97
1.1
1.2
563.0
202.6
u/ml
0.34
28
99
63
362
1.96
4.85
2.8
3.0
4.5
2.0
e6/l
0.37
35
195
51
273
2.06
4.77
2.4
2.1
22.6
22.5
%
0.02
42
238
25
100
2.65
4.52
1.1
1.0
—
—
—
0
0
72
445
1.84
4.41
1.8
1.7
391.6
438.3
pmol/l
0.98
58
360
52
289
1.98
4.38
22.1
22.0
1.1
1.3
inr
—
8
42
66
400
1.85
4.29
2.0
1.6
1299.7
1218.7
nmol/l
0.27
51
295
204
1695
1.78
4.25
4.4
3.6
14.5
14.8
pmol/l
0.59
188
1510
124
906
1.67
4.17
2.1
1.9
95.8
94.7
pmol/l
0.08
63
465
137
1028
1.66
4.15
5.0
4.2
—
—
—
0
0
72
454
1.79
4.11
1.4
1.2
1.0
1.3
u/ml
0.25
23
131
17
58
3.06
4.08
1.4
1.5
—
—
—
0
0
252
2255
2.35
4.06
26.0
13.8
20.1
24.2
mg/l
1.51
223
1760
11
28
4.05
4.01
1.9
1.5
—
—
—
0
0
15
49
3.18
3.87
1.2
1.2
—
—
—
0
0
9
15
6.16
3.84
1.3
1.4
—
—
—
0
0
96
668
1.67
3.82
3.7
3.0
1317.8
1180.1
ng/l
0.15
78
559
13
39
3.45
3.81
2.0
1.6
—
—
—
0
0
14
45
3.22
3.70
1.1
1.2
—
1.1
—
0
5
8
12
6.83
3.70
1.7
1.5
—
—
—
0
0
7
9
7.94
3.58
1.7
1.4
—
—
—
0
0
15
52
2.99
3.52
1.7
1.8
2904.1
8030.3
u/l
—
8
12
11
31
3.65
3.52
1.7
1.6
—
—
—
0
0
61
384
1.76
3.46
2.8
2.8
1.1
1.0
e6/l
0.08
33
216
43
244
1.90
3.40
6.2
10.2
5.3
5.0
kpa
1.59
43
234
50
298
1.83
3.40
6.0
7.3
104.7
104.0
mmol/l
0.55
50
292
7
10
7.15
3.38
1.7
1.4
—
—
—
0
0
17
65
2.72
3.37
1.9
1.8
—
—
—
0
0
43
245
1.89
3.36
6.2
10.2
1.3
1.2
mmol/l
0.14
34
196
14
49
2.96
3.24
1.4
1.4
—
—
—
0
0
14
49
2.96
3.24
1.4
1.4
—
—
—
0
0
14
50
2.90
3.13
1.8
1.4
—
—
—
0
0
16
62
2.68
3.10
5.3
2.6
—
—
—
0
0
218
1907
1.68
3.09
27.4
16.9
13.7
13.7
%
0.26
213
1875
11
35
3.23
2.96
1.7
1.6
—
—
—
0
0
10
30
3.42
2.93
1.8
1.6
—
—
—
0
0
34
188
1.92
2.91
2.4
2.5
5.3
6.1
ug/l
0.15
29
164
6
9
6.78
2.88
2.3
5.2
—
—
—
0
0
120
930
1.51
2.85
3.2
2.5
90.8
129.4
ug/l
2.08
112
838
8
18
4.54
2.81
2.4
1.7
—
—
—
0
0
177
1492
1.52
2.78
4.1
3.0
54.5
50.1
u/l
0.23
164
1379
31
169
1.94
2.76
4.5
2.9
67.9
64.6
ml/min/173m2
0.14
14
73
35
199
1.87
2.76
6.6
11.6
123.8
120.8
g/l
0.40
35
192
233
2096
1.72
2.72
5.6
4.3
1.8
1.9
mu/l
0.71
216
1889
9
24
3.84
2.69
1.1
1.1
—
—
—
0
0
14
55
2.63
2.66
2.5
1.6
—
—
—
0
0
62
422
1.61
2.59
2.6
2.8
2.4
2.5
mmol/l
0.70
56
369
34
196
1.84
2.57
3.8
3.7
1.7
2.3
mmol/l
0.35
29
155
13
50
2.68
2.57
1.1
1.2
—
—
—
0
0
11
39
2.90
2.50
2.0
1.6
—
—
—
0
0
14
58
2.49
2.41
1.4
1.5
310.9
307.4
mu/l
0.01
14
58
14
58
2.49
2.41
2.5
1.6
—
—
—
0
0
24
128
1.96
2.30
1.5
1.4
—
—
—
0
0
15
68
2.28
2.15
1.1
1.2
—
—
—
0
0
15
68
2.28
2.15
1.1
1.2
—
—
—
0
0
38
240
1.68
2.13
2.3
1.7
1.5
1.5
%
0.16
33
210
52
356
1.57
2.12
1.6
1.4
—
—
—
0
0
235
2163
1.58
1.98
21.3
13.0
81.5
80.2
ml/min/173m2
0.41
205
1760
8
27
3.02
1.95
1.0
1.1
—
—
—
0
0
5
12
4.22
1.83
1.0
1.2
—
—
—
0
0
256
2419
1.80
1.79
14.3
10.2
29.5
26.0
u/l
0.43
251
2325
14
68
2.12
1.73
4.8
3.8
—
3.2
—
0
7
7
24
2.96
1.73
1.1
1.6
16.9
17.0
ug/l
—
7
24
5
13
3.90
1.72
1.0
1.2
—
—
—
0
0
13
62
2.15
1.68
1.7
1.2
—
—
—
0
0
23
137
1.74
1.61
1.2
1.2
57.6
139.7
iu/ml
—
5
54
6
20
3.04
1.59
1.3
1.2
—
—
—
0
0
5
15
3.37
1.53
1.6
1.2
—
—
—
0
0
10
45
2.27
1.48
1.1
1.3
4.4
4.2
e6/l
—
5
33
11
210
0.50
1.43
2.3
1.7
—
—
—
0
0
227
2117
1.41
1.36
6.6
5.5
40.3
39.7
mmol/mol
0.40
213
1955
6
24
2.53
1.31
1.0
1.1
—
—
—
0
0
21
130
1.67
1.31
2.3
1.6
—
—
—
0
0
9
44
2.08
1.28
1.1
1.2
104.6
13.1
u/l
—
9
37
65
518
1.33
1.19
1.6
1.5
20.3
21.4
nmol/l
0.19
55
437
234
2215
1.37
1.08
5.1
4.4
6.1
6.0
mmol/l
0.64
213
1996
20
298
0.65
1.08
5.0
4.2
27.6
31.2
%
0.69
13
187
34
249
1.42
1.04
3.0
4.3
3.1
52.6
ug/l
0.90
27
205
16
99
1.65
1.02
1.3
1.8
—
—
—
0
0
10
55
1.85
0.93
1.2
1.2
—
—
—
0
0
6
29
2.09
0.90
1.7
1.2
—
—
—
0
0
151
1372
1.22
0.89
3.5
2.9
—
—
—
0
0
11
65
1.72
0.83
10.0
5.2
3.9
3.8
mmol/l
0.33
11
59
13
82
1.61
0.79
5.3
2.3
—
—
—
0
0
5
25
2.02
0.73
3.4
1.9
—
—
—
0
0
5
25
2.02
0.73
1.2
1.1
—
—
—
0
0
12
76
1.61
0.73
1.2
1.8
—
—
—
0
0
63
541
1.21
0.64
3.5
2.2
—
—
—
0
0
11
71
1.57
0.63
1.3
1.5
—
—
—
0
0
5
30
1.68
0.61
3.4
1.5
—
—
—
0
0
5
30
1.68
0.61
3.4
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
16
114
1.43
0.60
1.3
1.4
—
—
—
0
0
15
107
1.42
0.56
1.6
2.4
1.0
1.3
%
1.07
15
107
7
45
1.57
0.49
1.9
1.2
—
—
—
0
0
5
31
1.62
0.43
1.0
1.2
—
—
—
0
0
222
2153
1.16
0.41
4.2
3.9
1.5
1.3
mmol/l
4.10
203
1963
8
61
1.32
0.40
1.1
1.1
—
—
—
0
0
8
61
1.32
0.40
1.3
1.1
—
14.6
—
0
7
5
35
1.44
0.39
1.0
1.1
—
—
—
0
0
68
621
1.13
0.33
1.8
1.6
1.8
1.4
mmol/l
1.61
55
509
6
88
0.67
0.33
1.5
1.5
—
—
—
0
0
86
800
1.11
0.31
4.1
4.9
1.5
2.6
ug/l
1.75
78
709
227
2223
1.12
0.26
4.7
4.3
1.3
1.5
mmol/l
5.70
208
2030
24
207
1.17
0.26
1.8
1.8
—
—
—
0
0
26
227
1.16
0.25
1.9
1.9
—
—
—
0
0
5
38
1.32
0.23
1.2
1.2
0.5
0.8
nmol/l
—
5
29
5
41
1.22
0.22
1.2
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
29
260
1.13
0.20
10.4
6.5
—
—
—
0
0
11
94
1.18
0.13
2.1
1.9
—
—
—
0
0
226
2235
1.06
0.11
4.9
4.3
4.4
4.7
mmol/l
4.08
207
2048
34
323
1.06
0.08
1.7
1.5
—
—
—
0
0
231
2292
1.05
0.07
5.5
4.8
2.6
2.8
mmol/l
2.71
214
2092
9
87
1.04
0.07
1.4
1.7
—
—
—
0
0
204
2058
0.97
0.06
25.6
15.0
40.4
39.9
%
0.32
139
1513
46
461
1.00
0.00
2.8
3.0
0.6
0.7
ug/l
1.36
33
312
63
633
0.99
0.00
4.1
4.3
24.4
20.9
%
0.59
25
309
7
70
1.00
0.00
1.4
1.5
—
—
—
0
0
6
68
0.88
0.00
2.7
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
0.00
0.0
3.6
—
—
—
0
0
0
7
0.00
0.00
0.0
3.6
—
—
—
0
0
5
52
0.96
0.00
1.2
1.3
—
—
—
0
0
6
68
0.88
0.00
1.3
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
0.3
—
0
5
5
50
1.00
0.00
3.6
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_ICNEUROP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ICNEUROP | 1.431 [1.19, 1.73] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 163 out of 876 females with G6_ICNEUROP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ICNEUROP | 1.58 [1.33, 1.88] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 185 out of 723 males with G6_ICNEUROP died.
Mortality risk
Mortality risk for people of age
years, who have G6_ICNEUROP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | 0.338% |
| 5 | 0.74% | 1.76% |
| 10 | 1.955% | 4.785% |
| 15 | 3.823% | 9.4% |
| 20 | 6.455% | 15.462% |
Relationships between endpoints
↥Index endpoint: G6_ICNEUROP – Intercostal neuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data