Risteys · G6_ICNEUROP

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G58.0 Cause of death: ICD-10 — G58.0 2 out of 7 registries used, show all original rules.	276
4. Check minimum number of events None	276
5. Include endpoints None	276
6. Filter based on genotype QC (FinnGen only)	276

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1814	986	815
Only index persons	1687	950	737
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.02
Only index persons	0.03	0.03	0.03
Median age at first event (years)
Whole population	55.78	56.59	54.97
Only index persons	55.47	56.25	54.47

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	276	150	126
Unadjusted period prevalence (%)	0.05	0.05	0.06
Median age at first event (years)	56.87	54.84	59.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
254: Matched controls
2540

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G58.0

ICD-10 Finland

Intercostal neuropathy

+∞

323.0

254

N03AX12

ATC

gabapentin; oral

13.2

62.3

125

173

N03AX16

ATC

pregabalin; oral

9.8

57.7

150

326

N02AX02

ATC

tramadol; systemic, rectal

8.3

50.6

195

725

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

8.5

36.3

152

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

4.9

30.7

147

558

N06AA09

ATC

amitriptyline; systemic

8.3

30.0

115

N06AX21

ATC

duloxetine; oral

6.9

24.0

121

G56.0

ICD-10 Finland

Carpal tunnel syndrome

14.7

22.0

R52.2

ICD-10 Finland

Other chronic pain

11.8

19.9

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

41.9

18.9

M25.5

ICD-10 Finland

Pain in joint

3.8

18.9

101

378

R07.4

ICD-10 Finland

Chest pain, unspecified

3.6

17.8

105

419

M79.6

ICD-10 Finland

Pain in limb

3.3

17.1

118

529

R10.1

ICD-10 Finland

Pain localized to upper abdomen

4.1

16.6

233

N02AA05

ATC

oxycodone; systemic

4.2

16.0

204

M75.1

ICD-10 Finland

Rotator cuff syndrome

3.6

15.4

307

A02BC02

ATC

pantoprazole; systemic

3.1

15.0

190

1241

A02BC03

ATC

lansoprazole; oral

3.1

14.6

100

434

M79.2

ICD-10 Finland

Neuralgia and neuritis, unspecified

14.6

14.5

N06AA10

ATC

nortriptyline; systemic

20.7

14.5

M79.1

ICD-10 Finland

Myalgia

4.5

14.4

148

M54.5

ICD-10 Finland

Low back pain

3.0

14.4

109

504

M54.6

ICD-10 Finland

Pain in thoracic spine

5.9

14.3

M54.4

ICD-10 Finland

Lumbago with sciatica

4.0

14.3

188

R07.3

ICD-10 Finland

Other chest pain

5.0

14.0

110

M03BX02

ATC

tizanidine; oral

2.9

13.6

178

1143

R52.9

ICD-10 Finland

Pain, unspecified

5.2

13.6

A02BC05

ATC

esomeprazole; systemic

2.7

13.2

135

742

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

4.1

13.0

156

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.7

13.0

140

795

N03AF01

ATC

carbamazepine; oral, rectal

7.8

12.7

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.9

12.7

458

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

3.2

12.5

292

ACC59

NOMESCO Finland

Decompression and freeing of adhesions of peripheral nerve: other or unspecified

39.7

12.3

N03AX09

ATC

lamotrigine; oral

7.0

11.8

Z50.1

ICD-10 Finland

Other physical therapy

6.4

11.8

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.6

11.8

135

775

A06AD11

ATC

lactulose; oral

3.6

11.8

194

ACC51

NOMESCO Finland

Release of median nerve

125.5

11.5

A02BC01

ATC

omeprazole; systemic

2.7

11.5

467

R06.0

ICD-10 Finland

Dyspnoea

2.9

11.5

384

M54.3

ICD-10 Finland

Sciatica

6.4

11.5

Z01.8

ICD-10 Finland

Other specified special examinations

3.0

11.2

312

R51.80

ICD-10 Finland

Headache

3.6

11.0

173

G50.0

ICD-10 Finland

Trigeminal neuralgia

45.4

11.0

J45.9

ICD-10 Finland

Asthma, unspecified

3.1

10.6

241

G58.9

ICD-10 Finland

Mononeuropathy, unspecified

+∞

10.5

UGC12

NOMESCO Finland

Flexible bronchoscopy

4.2

10.2

104

G44.2

ICD-10 Finland

Tension-type headache

3.6

10.2

154

M01AB05

ATC

diclofenac; systemic, rectal

2.5

10.2

182

1281

N02AJ06

ATC

codeine and paracetamol; systemic

2.5

10.2

113

624

N02BE01

ATC

paracetamol; systemic, rectal

3.4

10.1

229

1849

N06AX16

ATC

venlafaxine; oral

3.4

10.1

173

M03BC01

ATC

orphenadrine (citrate); systemic

2.8

10.0

339

A01

ICPC

Pain general/multiple sites

4.6

9.9

TAC99

NOMESCO Finland

Other blockade for chronic pain

27.3

9.9

WZB00

NOMESCO Finland

Telephone receipt or other advice

2.6

9.8

432

J01MA14

ATC

moxifloxacin; systemic

4.3

9.7

N06AX11

ATC

mirtazapine; oral

2.5

9.6

507

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

2.9

9.4

259

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

5.8

9.4

J01MA12

ATC

levofloxacin; systemic

2.8

9.3

282

M01AH05

ATC

etoricoxib; oral

2.3

9.2

158

1064

N03AF02

ATC

oxcarbazepine; oral

6.6

8.8

TAC00

NOMESCO Finland

Peripheral nerve block

51.8

8.7

M54.9

ICD-10 Finland

Dorsalgia, unspecified

3.4

8.6

144

L05

ICPC

Flank/axilla symptom/complaint

5.0

8.6

L01

ICPC

Neck symptom/complaint

3.2

8.6

167

N05CF01

ATC

zopiclone; oral

2.3

8.5

532

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

9.0

8.4

G47.3

ICD-10 Finland

Sleep apnoea

2.6

8.4

324

J01FF01

ATC

clindamycin; systemic

2.4

8.4

424

N03AE01

ATC

clonazepam; systemic

5.1

8.4

L13

ICPC

Hip symptom/complaint

3.0

8.3

198

GD5BD

NOMESCO Finland

Thorax and upper abdomen combined extensive CT examination of

9.4

8.2

WX408

NOMESCO Finland

General anesthesy, balanced

2.4

8.0

441

N06CA01

ATC

amitriptyline and psycholeptics; systemic

3.3

8.0

135

7890A

ICD-9 Finland

Other symptoms involving abdomen and pelvis, Abdominal pain

5.4

7.9

R03AC02

ATC

salbutamol; inhalant

2.1

7.9

145

974

H02AB06

ATC

prednisolone; systemic

2.1

7.9

128

817

M01AX17

ATC

nimesulide; oral

2.4

7.9

367

M70.6

ICD-10 Finland

Trochanteric bursitis

3.4

7.7

120

R52.0

ICD-10 Finland

Acute pain

7.1

7.7

R52.1

ICD-10 Finland

Chronic intractable pain

25.9

7.6

K30

ICD-10 Finland

Functional dyspepsia

3.3

7.5

123

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

3.9

7.4

M01AB55

ATC

diclofenac, combinations; oral

4.0

7.4

TAC02

NOMESCO Finland

Block of intercostal nerve

+∞

7.3

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

3.8

7.3

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.7

7.3

213

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.6

7.2

247

S22.3

ICD-10 Finland

Fracture of rib

3.8

7.2

P01AB01

ATC

metronidazole; oral, rectal

2.1

7.2

109

667

WX110

NOMESCO Finland

Local anesthesy

2.1

7.2

183

1387

J01MA02

ATC

ciprofloxacin; systemic

2.1

7.2

112

696

G56.2

ICD-10 Finland

Lesion of ulnar nerve

31.0

7.2

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.1

7.2

113

703

C07AB07

ATC

bisoprolol; oral

2.1

7.2

131

867

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

4.9

7.1

M53.1

ICD-10 Finland

Cervicobrachial syndrome

3.4

7.1

111

M03BC51

ATC

orphenadrine, combinations; systemic

2.2

7.0

432

R42

ICD-10 Finland

Dizziness and giddiness

2.4

7.0

323

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

2.1

7.0

110

682

B02

ICD-10 Finland

Zoster [herpes zoster]

7.0

6.9

A06AC01

ATC

ispaghula (psylla seeds); oral

2.3

6.9

358

SPAT1153

SPAT

Removal of sutures

2.2

6.9

530

L28

ICPC

Limited function/disability (L)

2.7

6.9

207

M48.0

ICD-10 Finland

Spinal stenosis

2.9

6.9

160

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

3.6

6.9

N05AH04

ATC

quetiapine; oral

2.6

6.8

229

UJF32

NOMESCO Finland

Coloscopy

2.3

6.8

381

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

2.0

6.8

137

935

M01AH02

ATC

rofecoxib; oral

2.8

6.8

181

M50.1

ICD-10 Finland

Cervical disc disorder with radiculopathy

5.8

6.7

J02AC01

ATC

fluconazole; systemic

2.1

6.7

103

628

R02

ICPC

Shortness of breath/dyspnoea

2.9

6.6

160

XF404

NOMESCO Finland

Ambulatory ECG

3.2

6.5

112

NA2BG

NOMESCO Finland

Thoracal spine MRI examination with high intensity magnet

7.7

6.5

G58.8

ICD-10 Finland

Other specified mononeuropathies

71.6

6.5

M79.5

ICD-10 Finland

Residual foreign body in soft tissue

14.8

6.4

M01AH03

ATC

valdecoxib; oral

3.8

6.4

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

3.9

6.4

M01AH01

ATC

celecoxib; oral (coxibs)

2.4

6.4

273

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

3.2

6.4

114

J01.0

ICD-10 Finland

Acute maxillary sinusitis

2.3

6.3

325

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

2.1

6.3

534

G54.9

ICD-10 Finland

Nerve root and plexus disorder, unspecified

+∞

6.3

WX250

NOMESCO Finland

Intercostal blockade

27.4

6.3

A02BA04

ATC

nizatidine; systemic

3.5

6.2

N02AC04

ATC

dextropropoxyphene; oral

4.9

6.2

JN3BD

NOMESCO Finland

Extensive abdominal CT

3.0

6.2

134

Z71.8

ICD-10 Finland

Other specified counselling

2.2

6.2

365

H66.0

ICD-10 Finland

Acute suppurative otitis media

4.4

6.2

A02BA02

ATC

ranitidine; systemic

2.3

6.2

304

R03AK06

ATC

salmeterol and fluticasone; inhalant

2.6

6.1

201

Z02.7

ICD-10 Finland

Issue of medical certificate

4.0

6.1

N05BA01

ATC

diazepam; systemic, rectal

2.7

6.1

186

A03FA01

ATC

metoclopramide; systemic, rectal

2.3

6.0

315

Mortality – FinRegistry

↥

Association

Association between endpoint G6_ICNEUROP and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_ICNEUROP	1.431 [1.19, 1.73]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.055

During the follow-up period (1.1.1998 — 31.12.2019), 163 out of 876 females with G6_ICNEUROP died.

Males

Parameter	HR [95% CI]	p-value
G6_ICNEUROP	1.58 [1.33, 1.88]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.015

During the follow-up period (1.1.1998 — 31.12.2019), 185 out of 723 males with G6_ICNEUROP died.

Mortality risk

Mortality risk for people of age

years, who have G6_ICNEUROP.

N-year risk	Females	Males
1	0.147%	0.338%
5	0.74%	1.76%
10	1.955%	4.785%
15	3.823%	9.4%
20	6.455%	15.462%

Relationships between endpoints

↥

Index endpoint: G6_ICNEUROP – Intercostal neuropathy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	G6_ICNEUROP
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G580
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G580
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Intercostal neuropathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints