Disorders of myoneural junction and muscle in diseases classified elsewhere

G6_MYOMUSCINOTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G73*
  • Cause of death: ICD-10 G73*

2 out of 7 registries used, show all original rules.

270

4. Check minimum number of events

None

270

5. Include endpoints

None

270

6. Filter based on genotype QC (FinnGen only)

270

Control definitions (FinnGen only)

Control exclude
G6_MYONEU

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1357 973 377
Only index persons 1184 865 319
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.01
Only index persons 0.03 0.03 0.01
Median age at first event (years)
Whole population 61.99 62.44 60.81
Only index persons 61.00 61.15 60.58

-FinnGen-

Key figures

All Female Male
Number of individuals 270 204 66
Unadjusted period prevalence (%) 0.06 0.07 0.03
Median age at first event (years) 57.26 56.19 60.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
247
Matched controls
2468
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G73.7*M35.0
ICD-10 Finland
Myopathy in sicca syndrome [Sjögren]
+∞
99.9
89
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
96.2
92.7
99
17
P01BA02
ATC
hydroxychloroquine; oral
19.6
71.6
118
110
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
13.8
60.2
117
151
G73.7
ICD-10 Finland
Myopathy in other diseases classified elsewhere
+∞
46.3
43
*
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
115.6
44.6
47
5
L04AX01
ATC
azathioprine; systemic
18.9
39.5
62
43
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
10.7
31.7
65
80
G73.7*M32.1
ICD-10 Finland
Myopathy in systemic lupus erythematosus
+∞
30.9
29
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
9.2
27.5
61
85
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
84.7
27.4
30
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
7.1
24.8
66
121
M05BA04
ATC
alendronic acid; oral
7.6
24.7
62
104
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
62.8
24.6
28
5
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.2
24.5
140
590
H02AB07
ATC
prednisone; oral
5.3
24.2
86
226
H02AB06
ATC
prednisolone; systemic
4.0
23.0
170
881
G73.0*E05.9
ICD-10 Finland
Myasthenic syndromes in thyrotoxicosis [hyperthyroidism]
+∞
22.2
21
*
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
114.3
19.9
21
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
216.6
19.9
20
*
L04AA06
ATC
mycophenolic acid; systemic
25.1
19.5
27
12
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.5
19.5
151
766
G73.1*C80.99
ICD-10 Finland
Eaton-Lambert syndrome
+∞
19.0
18
*
G73.0*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic amyotrophy
+∞
17.9
17
*
N07AA02
ATC
pyridostigmine; systemic
+∞
17.9
17
*
H02AB04
ATC
methylprednisolone; systemic
4.3
16.7
70
209
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
6.4
16.5
45
83
G72.9
ICD-10 Finland
Myopathy, unspecified
+∞
14.7
14
*
G73.0*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic amyotrophy
+∞
14.7
14
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.9
14.5
50
121
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
+∞
13.7
13
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
147.8
13.6
14
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.8
13.3
142
810
M79.0
ICD-10 Finland
Rheumatism, unspecified
7.6
13.2
31
46
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
4.0
12.6
54
161
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
8.5
12.5
27
35
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
12.4
102
491
H04.10
ICD-10 Finland
Dry eye syndrome
4.0
12.3
52
153
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
6.7
12.1
31
52
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.2
11.7
47
132
G73.7*M05.3
ICD-10 Finland
Rheumatoid myopathy
125.6
11.5
12
*
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
125.6
11.5
12
*
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
125.6
11.5
12
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.2
11.2
44
121
C03CA01
ATC
furosemide; systemic
2.8
11.2
89
414
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
9.5
11.0
22
25
M32
ICD-10 Finland
Systemic lupus erythematosus
114.7
10.5
11
*
G70.0
ICD-10 Finland
Myasthenia gravis
+∞
10.5
10
*
L88
ICPC
Rheumatoid/seropositive arthritis
7.3
10.2
24
36
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.2
10.0
19
20
M35.1
ICD-10 Finland
Other overlap syndromes
27.3
9.9
13
5
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
57.3
9.7
11
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
5.0
9.7
31
69
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
31.4
9.5
12
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
103.8
9.5
10
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
9.4
71
315
108
Kela drug reimbursment
Myasthenia gravis
+∞
9.4
9
*
N06AA09
ATC
amitriptyline; systemic
3.4
9.0
45
151
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
8.1
8.8
19
25
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.5
8.8
31
77
N03AX16
ATC
pregabalin; oral
2.5
8.6
81
403
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
5.9
8.5
23
42
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.7
8.5
37
111
M33.2
ICD-10 Finland
Polymyositis
93.1
8.5
9
*
NXL00
NOMESCO Finland
Biopsy of muscle
93.1
8.5
9
*
C08CA05
ATC
nifedipine; systemic
4.3
8.4
31
80
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
7.5
8.4
19
27
S01KA02
ATC
hypromellose; ophthalmic
10.0
8.4
16
17
G73.1
ICD-10 Finland
Lambert-Eaton syndrome
+∞
8.4
8
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.0
8.3
50
192
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.6
8.2
38
120
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.6
8.2
28
67
R06.0
ICD-10 Finland
Dyspnoea
2.4
8.2
79
398
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
8.2
71
339
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.7
8.1
35
105
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
8.2
8.0
17
22
N03AX12
ATC
gabapentin; oral
2.8
8.0
55
228
L04AA01
ATC
[U] ciclosporin; systemic
9.9
7.9
15
16
SBA10
NOMESCO Finland
Measurement of excretion of saliva
15.7
7.8
12
8
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.5
7.8
36
114
ELA30
NOMESCO Finland
Biopsy of salivary gland
46.5
7.8
9
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.4
7.7
38
127
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
6.8
7.6
18
28
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
4.1
7.5
28
74
N06AX21
ATC
duloxetine; oral
3.0
7.3
42
156
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.9
7.3
23
51
R50.9
ICD-10 Finland
Fever, unspecified
2.9
7.2
46
183
H26.3
ICD-10 Finland
Drug-induced cataract
31.0
7.2
9
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
12.5
7.2
12
10
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
7.4
7.1
16
23
A02BC02
ATC
pantoprazole; systemic
2.1
7.0
174
1308
J01FF01
ATC
clindamycin; systemic
2.3
7.0
78
419
E0000UV
ATC
NA
2.1
7.0
110
686
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.9
6.9
43
168
L93.0
ICD-10 Finland
Discoid lupus erythematosus
41.2
6.8
8
*
L28
ICPC
Limited function/disability (L)
2.6
6.8
51
223
F34.1
ICD-10 Finland
Dysthymia
6.8
6.8
16
25
K11.2
ICD-10 Finland
Sialoadenitis
5.8
6.8
18
33
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
4.6
6.7
22
51
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
6.6
64
319
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
7.2
6.6
15
22
A10AA01
ATC
NA
7.2
6.6
15
22
M79.7
ICD-10 Finland
Fibromyalgia
5.0
6.6
20
43
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
6.6
36
127
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
4.7
6.5
21
48
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
71.6
6.5
7
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
14.8
6.4
10
7
S97
ICPC
Chronic ulcer skin
4.7
6.3
20
45
J02AC01
ATC
fluconazole; systemic
2.0
6.3
121
805
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.9
6.3
25
70
P01BA01
ATC
chloroquine; systemic
18.6
6.3
9
5
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
18.6
6.3
9
5
SBB10
NOMESCO Finland
Teeth copy
4.0
6.3
24
65
NJ3BG
NOMESCO Finland
MRI examination of extremities with high intensity magnet
+∞
6.3
6
*
N16.4*M32.1
ICD-10 Finland
Renal tubulo-interstitial disorders in systemic lupus erythematosus
+∞
6.3
6
*
R03CA02
ATC
ephedrine; oral
+∞
6.3
6
*
G73.0
ICD-10 Finland
Myasthenic syndromes in endocrine diseases
+∞
6.3
6
*
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.9
6.3
19
41
J01MA12
ATC
levofloxacin; systemic
2.4
6.2
55
261
H03AA01
ATC
levothyroxine sodium; systemic
2.1
6.2
79
446
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.3
6.1
30
100
UJF30
NOMESCO Finland
Ileoscopy through colon
3.1
6.1
34
122
M01AX17
ATC
nimesulide; oral
2.2
6.1
72
391
M01AH02
ATC
rofecoxib; oral
2.7
6.1
44
186
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.4
6.0
54
259

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
68
67
13.23
63.52
1.6
1.3
6.7
1.8
u/ml
—
28
10
108
305
5.23
37.37
1.7
1.4
1219.0
504.5
titre
2.51
59
75
174
727
4.92
36.32
11.4
5.1
—
—
—
0
0
75
165
5.91
34.25
4.3
2.6
11.3
10.1
g/l
1.07
64
154
35
33
12.04
32.89
1.4
1.2
—
—
—
0
0
195
1061
4.02
24.50
13.4
5.7
8.9
8.5
%
1.04
190
984
202
1127
4.15
24.41
12.9
5.4
0.6
0.6
e9/l
0.37
186
973
194
1055
3.98
24.32
13.0
5.4
2.8
2.7
%
0.08
189
972
202
1131
4.12
24.19
12.9
5.4
0.0
0.0
e9/l
0.17
186
976
197
1086
4.01
24.11
13.2
5.6
26.0
28.3
%
2.49
191
1002
190
1024
3.89
24.04
13.2
5.4
0.7
0.7
%
0.25
185
942
203
1153
4.07
23.49
12.8
5.4
1.6
1.9
e9/l
3.63
187
1023
204
1170
4.04
23.08
13.6
5.7
0.2
0.2
e9/l
0.03
186
1027
194
1077
3.85
23.07
12.5
5.3
59.5
57.1
%
2.13
188
1001
25
25
10.92
22.38
5.0
1.3
26.4
—
iu/ml
—
7
0
54
140
4.57
19.71
2.3
1.7
1.2
1.4
g/l
0.28
45
129
17
11
16.43
19.51
1.1
1.1
—
—
—
0
0
135
664
3.07
18.27
4.4
1.9
323.5
148.3
u/l
0.51
130
630
209
1327
3.54
17.85
16.1
9.3
4.0
4.0
e9/l
0.15
193
1163
49
127
4.49
17.81
7.6
3.2
7.4
7.4
ph
—
9
13
55
157
4.14
17.61
11.0
6.6
10.7
9.4
mmol/l
0.71
50
146
55
166
3.91
16.23
1.9
3.0
64.0
67.3
g/l
1.95
47
152
51
147
4.04
16.04
2.0
2.6
—
—
—
0
0
115
557
2.85
15.43
6.2
3.8
—
—
—
0
0
111
530
2.86
15.27
3.1
2.1
3.5
3.2
mg/l
0.73
97
454
52
166
3.64
14.05
2.3
2.8
61.2
71.7
e9/l
1.56
38
133
169
1031
2.71
13.96
10.0
5.3
1.2
1.2
mmol/l
0.28
159
924
67
256
3.15
13.57
11.9
5.0
1.1
1.0
mmol/l
0.09
61
230
22
35
6.75
13.50
3.5
3.4
56.3
61.4
%
0.70
22
35
22
35
6.75
13.50
3.4
2.9
3.6
5.2
e9/l
1.42
22
35
79
335
2.92
13.30
3.2
2.9
0.8
0.8
mmol/l
0.56
70
316
63
240
3.12
12.77
2.4
3.0
1.7
1.8
%
0.22
57
219
175
1122
2.59
12.49
12.1
6.2
1.2
1.2
mmol/l
0.32
148
949
48
158
3.48
12.31
4.9
4.8
0.5
0.5
%
0.06
25
37
119
649
2.49
11.89
4.8
3.7
—
—
—
0
0
34
90
4.18
11.88
2.3
2.3
1.8
1.7
g/l
0.24
27
77
121
669
2.47
11.69
5.2
3.1
26.3
150.9
e6/l
0.69
99
509
136
796
2.43
11.54
3.6
3.3
2.3
2.4
mmol/l
0.67
118
697
34
92
4.08
11.53
9.4
3.4
—
—
—
0
0
48
167
3.28
11.24
5.3
4.7
0.0
0.1
%
1.49
27
49
94
471
2.53
11.14
4.8
2.5
4.4
6.9
e6/l
0.66
84
412
17
26
6.91
10.76
2.0
2.0
—
—
—
0
0
133
789
2.35
10.73
6.0
3.7
70.8
68.7
e6/l
0.02
104
546
45
158
3.22
10.35
5.2
4.8
0.0
0.0
%
0.00
26
41
21
42
5.34
10.22
4.3
1.7
—
—
—
0
0
23
50
4.94
10.21
1.6
1.9
—
—
—
0
0
70
316
2.64
10.19
2.6
1.9
—
—
—
0
0
48
179
3.05
9.96
5.3
4.6
0.7
0.9
%
0.23
27
57
142
886
2.27
9.94
9.2
7.8
1.2
1.2
inr
0.12
35
258
223
1693
2.82
9.94
11.6
4.1
17.2
12.1
mm/h
5.11
215
1546
56
229
2.82
9.84
8.0
4.1
—
—
—
0
0
14
19
7.72
9.79
1.6
1.4
—
—
—
0
0
72
336
2.56
9.75
3.8
2.3
10.5
13.7
umol/l
3.45
66
308
58
244
2.75
9.65
2.3
1.5
—
—
—
0
0
229
1774
2.92
9.59
14.9
7.1
75.5
78.3
u/l
0.54
224
1646
21
45
4.98
9.47
2.2
1.7
124.6
129.7
g/l
0.33
13
30
209
1553
2.53
9.47
11.4
4.3
—
—
—
0
0
19
38
5.30
9.24
1.3
1.1
3.7
4.4
u/ml
0.14
11
16
149
969
2.20
9.18
7.5
4.0
34.1
35.8
g/l
2.83
135
905
11
12
9.51
9.04
2.0
2.1
—
—
—
0
0
107
613
2.23
9.01
5.4
2.9
0.3
0.5
e6/l
0.82
86
448
14
21
6.98
8.98
1.3
1.2
—
—
—
0
0
19
39
5.16
8.98
2.8
2.2
—
—
—
0
0
27
74
3.94
8.97
4.4
3.0
0.5
0.2
g/l
0.92
14
22
105
599
2.23
8.92
5.5
2.8
—
—
—
0
0
37
128
3.19
8.68
3.3
3.6
3.9
4.5
pmol/l
2.28
32
108
149
987
2.14
8.54
3.9
2.7
152.6
99.4
ug/l
1.76
134
906
12
6
20.83
8.54
1.1
1.0
—
—
—
0
0
12
6
20.83
8.54
1.1
1.0
—
—
—
0
0
12
6
20.83
8.54
1.1
1.0
—
—
—
0
0
19
41
4.91
8.49
5.0
2.4
2.0
2.6
mmol/l
0.48
12
25
140
909
2.12
8.42
2.3
2.0
101.6
96.6
pmol/l
0.57
78
454
62
289
2.49
8.31
4.3
2.3
20.1
23.1
%
0.97
54
245
14
23
6.37
8.26
3.3
3.3
—
—
—
0
0
159
1091
2.11
8.18
5.8
3.7
0.0
0.0
estimate
0.00
35
207
64
305
2.44
8.17
4.1
2.2
2.1
2.4
g/l
2.56
58
280
65
316
2.39
7.92
1.8
1.7
—
—
—
0
0
51
222
2.60
7.85
1.8
1.5
—
—
—
0
0
19
44
4.57
7.81
1.4
1.5
—
—
—
0
0
11
6
19.03
7.66
1.5
1.8
—
—
—
0
0
11
15
7.60
7.61
2.6
1.9
0.8
0.9
e9/l
—
6
6
159
1113
2.04
7.49
6.0
3.7
0.0
0.0
estimate
0.00
31
197
20
50
4.24
7.49
1.3
1.2
—
—
—
0
0
78
421
2.20
7.39
4.9
2.6
461.8
546.5
mosm/kgh2o
2.95
70
351
58
276
2.40
7.38
1.8
1.5
—
—
—
0
0
129
842
2.02
7.36
6.1
3.6
44.5
37.3
ng/l
0.23
96
573
23
65
3.77
7.32
1.9
4.5
45.6
165.2
mg/l
0.66
17
53
23
65
3.77
7.32
1.9
4.6
32.4
28.1
mg/l
0.36
16
53
30
102
3.18
7.23
1.3
1.2
—
—
—
0
0
19
48
4.18
7.02
5.4
2.6
7.4
7.4
ph
0.07
19
40
156
1102
1.98
6.97
7.6
4.9
0.0
0.0
estimate
0.00
34
207
66
343
2.22
6.81
1.4
1.2
—
—
—
0
0
127
842
1.96
6.77
5.1
3.5
—
—
—
0
0
24
74
3.46
6.73
1.7
1.4
313.1
324.9
ug/g
0.12
16
40
42
181
2.56
6.56
6.5
3.4
113.4
82.3
ng/l
0.98
33
158
110
700
1.96
6.56
8.0
3.7
7.4
7.4
ph
0.51
25
124
39
164
2.61
6.40
3.3
2.3
3.3
4.1
e9/l
0.97
27
122
89
530
2.01
6.39
1.5
1.3
3.5
1.6
u/ml
0.26
17
145
12
22
5.66
6.34
1.5
1.0
—
—
—
0
0
75
421
2.08
6.32
2.3
1.7
1261.5
1143.5
nmol/l
0.56
61
312
16
39
4.30
6.18
1.4
1.3
—
—
—
0
0
81
473
2.02
6.10
2.3
1.4
2.7
2.4
g/l
0.52
54
271
28
103
2.92
5.90
1.6
1.7
—
—
—
0
0
46
219
2.33
5.79
1.3
1.4
—
—
—
0
0
17
46
3.88
5.74
2.6
1.5
2580.5
22331.0
e6/l
0.83
11
30
17
46
3.88
5.74
1.8
5.7
—
—
—
0
0
90
560
1.91
5.57
3.6
2.8
353.8
5894.5
umol/l
2.22
76
481
32
131
2.64
5.53
1.3
1.2
309.3
350.6
u/ml
0.06
26
118
108
718
1.84
5.41
3.2
2.3
55.0
56.7
u/l
0.23
96
659
91
574
1.88
5.38
10.9
7.0
—
—
—
0
0
72
420
1.97
5.37
1.3
1.3
49.3
30.5
iu/ml
0.86
31
141
13
30
4.50
5.35
2.7
3.6
—
—
—
0
0
88
554
1.87
5.20
5.3
3.3
93.4
94.7
%
0.18
88
544
12
27
4.60
5.09
1.5
1.4
—
—
—
0
0
105
706
1.80
4.98
3.0
2.1
—
—
—
0
0
85
537
1.85
4.94
1.5
1.5
21.7
22.1
nmol/l
0.08
73
444
159
1216
1.75
4.74
6.7
5.7
9.0
10.6
umol/l
2.43
148
1152
21
75
2.95
4.67
2.0
2.3
36.0
37.7
g/l
0.45
15
66
80
505
1.83
4.62
2.2
1.6
1.2
1.0
mg/l
0.39
63
402
13
34
3.97
4.59
2.6
1.6
—
—
—
0
0
8
8
10.26
4.55
1.0
1.1
—
—
—
0
0
166
1294
1.73
4.54
7.2
4.3
6.5
6.6
mmol/l
0.18
157
1204
141
1054
1.71
4.47
4.0
3.6
—
—
—
0
0
53
295
1.99
4.46
1.7
1.3
—
—
—
0
0
91
604
1.76
4.42
6.5
4.0
0.0
0.0
estimate
0.00
32
208
17
56
3.17
4.32
2.3
1.6
10.3
5.7
iu/l
—
6
18
71
442
1.82
4.25
2.9
2.7
2.5
2.5
mmol/l
0.01
62
391
133
993
1.67
4.13
20.9
9.0
0.0
0.0
e9/l
0.25
114
805
210
1776
1.82
4.06
5.9
4.1
15.2
14.8
pmol/l
1.65
190
1599
14
43
3.38
3.96
5.8
2.0
—
—
—
0
0
36
181
2.14
3.96
8.0
3.3
—
—
—
0
0
9
15
6.17
3.85
1.1
1.0
—
—
—
0
0
72
465
1.75
3.77
1.6
1.8
471.5
470.9
pmol/l
0.01
58
384
17
63
2.81
3.56
4.1
3.3
—
—
—
0
0
75
501
1.69
3.45
9.1
5.2
—
—
—
0
0
99
711
1.62
3.44
4.1
2.8
—
—
—
0
0
75
503
1.68
3.40
5.8
3.7
—
—
—
0
0
11
32
3.54
3.37
1.1
1.0
—
—
—
0
0
63
404
1.73
3.36
1.3
1.3
17.5
10.9
u/ml
0.17
15
150
28
137
2.16
3.30
1.4
1.5
—
—
—
0
0
33
173
2.03
3.27
1.5
1.5
—
—
—
0
0
94
677
1.60
3.18
5.1
3.0
6.8
7.1
mmol/l
0.33
78
562
13
44
3.05
3.18
2.6
3.2
0.9
1.0
nmol/l
—
8
35
33
176
2.00
3.12
7.3
3.6
1.2
1.2
mmol/l
0.37
28
158
16
62
2.68
3.10
1.6
2.1
10.8
12.0
mg/l
0.26
16
56
41
240
1.84
2.96
7.1
6.5
0.9
1.3
mmol/l
0.16
32
195
34
188
1.92
2.91
2.1
2.4
3.7
6.2
ug/l
0.77
24
166
26
132
2.07
2.81
5.3
4.2
—
—
—
0
0
5
6
8.46
2.76
1.0
1.0
1752.0
1828.2
miu/ml
—
5
6
8
19
4.31
2.70
4.1
2.8
—
—
—
0
0
33
187
1.87
2.64
1.2
1.2
—
—
—
0
0
32
182
1.86
2.53
6.3
3.2
—
—
—
0
0
87
644
1.52
2.53
5.4
3.1
1661.0
143.1
mg/l
0.76
58
395
11
39
2.90
2.50
1.1
1.7
—
—
—
0
0
8
21
3.89
2.48
1.0
1.2
—
—
—
0
0
90
675
1.50
2.45
6.6
3.9
18.6
6.7
mg/mmol
1.58
57
403
59
823
0.64
2.41
4.0
2.9
—
—
—
0
0
9
27
3.41
2.41
1.1
1.0
—
—
—
0
0
6
12
5.09
2.41
1.2
1.9
—
—
—
0
0
5
8
6.34
2.38
6.4
5.6
—
—
—
0
0
7
17
4.20
2.37
1.1
1.2
—
—
—
0
0
6
13
4.69
2.28
1.3
1.2
—
—
—
0
0
9
29
3.17
2.24
2.8
2.7
—
—
—
0
0
244
2262
1.82
2.23
34.3
13.1
23.4
22.1
mg/l
0.22
222
1764
7
19
3.75
2.16
1.3
1.1
—
—
—
0
0
7
19
3.75
2.16
1.9
1.3
—
—
—
0
0
7
19
3.75
2.16
1.9
1.7
—
—
—
0
0
8
25
3.27
2.11
1.8
1.5
32.3
32.4
pg
—
8
25
9
31
2.97
2.09
1.1
1.2
—
—
—
0
0
5
10
5.07
2.08
6.4
4.7
—
—
—
0
0
6
15
4.07
2.05
1.2
1.1
—
—
—
0
0
42
278
1.60
1.97
39.6
19.9
1.4
1.3
inr
—
6
43
120
982
1.40
1.97
2.5
2.1
—
—
—
0
0
30
184
1.71
1.88
8.4
3.9
5.6
5.9
kpa
1.05
30
179
6
17
3.58
1.84
6.7
1.6
14.7
17.2
ug/l
—
6
17
5
12
4.22
1.83
1.6
1.3
—
—
—
0
0
5
12
4.22
1.83
1.4
2.3
1328.8
676.2
u/ml
—
5
12
5
12
4.22
1.83
1.0
1.0
—
—
—
0
0
59
429
1.48
1.83
5.1
3.4
929.3
185.8
ng/l
0.40
47
328
230
2126
1.55
1.80
7.2
4.9
1.8
2.5
mu/l
0.59
212
1930
42
285
1.56
1.79
1.2
1.3
—
—
—
0
0
6
19
3.20
1.67
1.0
1.2
—
—
—
0
0
27
167
1.69
1.66
12.2
7.4
—
—
—
0
0
42
291
1.52
1.64
1.9
2.1
147.8
107.8
ug/g
0.55
32
233
28
176
1.66
1.62
2.7
2.6
—
6.3
—
0
7
5
14
3.62
1.62
1.8
1.1
—
—
—
0
0
5
15
3.38
1.53
2.0
1.2
2.6
1.9
mmol/l
—
5
15
6
21
2.90
1.51
2.0
2.3
—
—
—
0
0
20
121
1.71
1.35
6.7
8.2
95.0
94.3
%
0.37
20
121
5
115
0.42
1.28
1.6
1.8
—
—
—
0
0
74
596
1.33
1.26
5.8
3.3
—
—
—
0
0
6
25
2.43
1.25
1.5
1.9
92.7
90.2
%
—
6
25
9
45
2.03
1.24
2.1
1.3
—
—
—
0
0
36
258
1.46
1.22
7.4
6.1
104.0
103.8
mmol/l
0.09
36
251
30
207
1.51
1.21
2.0
1.5
—
—
—
0
0
26
174
1.55
1.21
2.3
2.9
39.2
46.9
u/ml
0.12
26
168
5
20
2.53
1.15
2.0
2.9
—
—
—
0
0
22
144
1.57
1.13
1.5
1.6
—
—
—
0
0
61
486
1.33
1.12
7.2
4.1
1.0
1.0
kg/l
0.05
15
61
8
147
0.53
1.07
1.5
1.4
—
—
—
0
0
23
155
1.53
1.05
5.1
2.7
4.5
4.4
kpa
0.13
23
150
5
22
2.30
1.04
1.0
1.1
—
—
—
0
0
0
30
0.00
0.98
0.0
1.1
—
—
—
0
0
6
27
2.25
0.94
5.0
17.7
7.7
7.0
mmol/l
—
6
21
13
206
0.61
0.93
1.2
1.3
—
—
—
0
0
6
29
2.09
0.90
1.3
1.1
—
—
—
0
0
6
31
1.96
0.85
1.5
1.3
—
—
—
0
0
6
32
1.89
0.82
1.5
1.3
—
—
nmol/l
—
0
0
32
243
1.36
0.82
2.1
2.2
3.9
7.8
umol/l
3.23
26
210
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
5
25
2.02
0.73
1.6
1.0
—
—
—
0
0
15
101
1.51
0.72
11.2
7.7
—
—
—
0
0
15
102
1.50
0.69
1.1
1.1
—
—
—
0
0
5
28
1.80
0.66
1.6
1.3
—
—
—
0
0
23
173
1.36
0.64
1.2
1.2
229.6
180.4
iu/ml
—
7
74
5
30
1.68
0.61
1.0
1.0
—
0.2
—
0
6
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
11
72
1.55
0.60
3.0
4.2
—
—
—
0
0
6
37
1.64
0.56
1.0
1.2
—
—
—
0
0
213
2045
1.20
0.55
29.2
14.1
36.7
39.8
%
2.98
135
1508
7
45
1.57
0.49
1.1
1.6
—
—
—
0
0
228
2213
1.19
0.45
5.5
4.6
6.0
5.9
mmol/l
0.25
207
2024
12
88
1.38
0.40
1.3
1.2
—
—
—
0
0
247
2512
0.80
0.39
47.2
19.6
91.3
91.2
fl
0.16
247
2471
11
82
1.36
0.34
1.5
2.7
—
—
—
0
0
19
156
1.23
0.32
4.5
2.7
—
—
—
0
0
8
64
1.26
0.27
1.8
1.4
—
245.6
—
0
29
8
64
1.26
0.27
1.1
1.2
—
—
—
0
0
155
1601
0.93
0.23
5.7
3.7
—
—
—
0
0
5
39
1.29
0.23
2.2
2.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
50
1.20
0.20
7.3
2.4
—
—
—
0
0
216
2122
1.09
0.19
7.6
5.7
40.3
39.7
mmol/mol
0.42
197
1970
5
67
0.74
0.17
45.0
10.0
—
—
—
0
0
7
87
0.80
0.15
1.6
1.3
—
—
—
0
0
22
243
0.90
0.14
3.7
3.0
0.8
0.7
ug/l
0.17
17
150
8
96
0.83
0.14
5.9
2.4
0.6
0.7
%
—
8
96
28
257
1.10
0.14
2.6
4.2
3.2
24.2
ug/l
0.70
22
215
8
100
0.79
0.14
5.9
2.3
1.1
1.1
%
—
8
100
15
132
1.14
0.13
1.3
1.3
—
—
—
0
0
13
114
1.15
0.12
3.2
2.5
—
—
—
0
0
11
95
1.16
0.12
1.0
1.1
—
—
—
0
0
30
279
1.08
0.11
1.3
1.3
—
—
—
0
0
218
2156
1.06
0.10
4.7
3.9
1.4
1.3
mmol/l
1.54
194
1969
5
46
1.09
0.09
1.4
1.3
—
—
—
0
0
5
48
1.04
0.09
1.2
1.2
—
—
—
0
0
226
2240
1.05
0.08
5.1
4.4
1.5
1.5
mmol/l
1.43
205
2061
7
64
1.10
0.08
1.3
1.3
—
—
—
0
0
7
64
1.10
0.08
2.6
3.8
3.5
3.8
mmol/l
—
7
57
7
64
1.10
0.08
1.3
1.3
—
—
—
0
0
7
64
1.10
0.08
1.3
1.3
—
—
—
0
0
232
2302
1.06
0.08
5.6
5.0
2.7
2.8
mmol/l
1.32
210
2114
21
225
0.93
0.07
1.9
1.8
—
—
—
0
0
55
564
0.97
0.04
1.4
1.4
—
—
—
0
0
17
180
0.94
0.04
1.6
1.3
—
—
—
0
0
227
2258
1.03
0.04
5.1
4.4
4.6
4.8
mmol/l
1.40
206
2086
10
101
0.99
0.00
2.5
3.4
—
—
—
0
0
66
661
1.00
0.00
1.6
1.6
1.8
1.4
mmol/l
0.62
55
560
237
2373
0.99
0.00
30.1
12.2
—
—
—
0
0
6
64
0.94
0.00
1.3
1.3
—
—
—
0
0
6
60
1.00
0.00
1.2
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
6
59
1.02
0.00
1.3
1.3
—
—
—
0
0
8
84
0.95
0.00
1.5
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
51
0.98
0.00
1.4
1.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
14
140
1.00
0.00
1.1
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_MYOMUSCINOTH and mortality.

Females

Parameter HR [95% CI] p-value
G6_MYOMUSCINOTH 2.496 [2.04, 3.06] < 0.001
Birth year 1.002 [0.99, 1.01] 0.715

During the follow-up period (1.1.1998 — 31.12.2019), 313 out of 874 females with G6_MYOMUSCINOTH died.

Males

Parameter HR [95% CI] p-value
G6_MYOMUSCINOTH 2.303 [1.64, 3.22] < 0.001
Birth year 0.984 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 124 out of 312 males with G6_MYOMUSCINOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_MYOMUSCINOTH.

N-year risk Females Males
1 0.284% 0.376%
5 1.534% 2.586%
10 3.878% 6.089%
15 7.889% 11.542%
20 14.235% 18.932%

Relationships between endpoints

Index endpoint: G6_MYOMUSCINOTH – Disorders of myoneural junction and muscle in diseases classified elsewhere

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data