muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
387 |
4. Check minimum number of eventsNone |
387 |
5. Include endpointsNone |
387 |
6. Filter based on genotype QC (FinnGen only) |
387 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M79
- Name in latin
- Hypertrophia corporis adiposi infrapatellaris
Similar endpoints
↥List of similar endpoints to
Hypertrophy of (infrapatellar) fat pad
based on the number of shared cases.
Similar with more cases:
- Other soft tissue disorders, not elsewhere classified
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2650 | 1415 | 1223 |
| Only index persons | 2524 | 1364 | 1160 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 38.04 | 39.91 | 35.86 |
| Only index persons | 37.48 | 39.43 | 35.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 387 | 232 | 155 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.07 |
| Median age at first event (years) | 37.97 | 36.40 | 40.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 369
- Matched controls
- 3689
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M79.4
ICD-10 Finland
Hypertrophy of (infrapatellar) fat pad
+∞
309.7
252
*
7293A
ICD-9 Finland
Other disorders of soft tissues, Panniculitis, unspecified[LIPOSYNOVITIS INFRAPATELLARIS (MORBUS HOFFA)]
+∞
131.2
118
*
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
67.9
66.9
76
14
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
14.5
53.7
95
86
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
6.9
35.8
98
183
1225
FHL
Arthroscopy and other therapeutic procedure
23.8
33.6
48
23
M23.8
ICD-10 Finland
Other internal derangements of knee
14.8
32.9
56
44
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
13.9
29.3
51
42
M79.6
ICD-10 Finland
Pain in limb
3.9
28.6
150
550
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
5.3
26.1
87
201
M25.5
ICD-10 Finland
Pain in joint
3.7
25.9
144
543
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.2
25.0
207
1047
1222
FHL
Arthroscopy and synovial surgery
33.6
24.1
31
10
M01AH05
ATC
etoricoxib; oral
3.1
22.9
255
1544
M17.1
ICD-10 Finland
Other primary gonarthrosis
4.2
22.2
95
281
N02AX02
ATC
tramadol; systemic, rectal
3.0
21.1
172
829
M75.1
ICD-10 Finland
Rotator cuff syndrome
4.3
21.1
86
242
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
28.9
20.3
27
10
N03AX16
ATC
pregabalin; oral
3.6
19.9
104
360
1220
FHL
Arthroscopy
8.2
19.4
44
60
SPAT1153
SPAT
Removal of sutures
3.0
18.5
136
601
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
3.1
17.8
120
498
M79.0
ICD-10 Finland
Rheumatism, unspecified
38.8
17.8
22
6
SPAT1249
SPAT
Treatment-related counselling outside office
2.7
17.6
176
933
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
25.5
17.5
24
10
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.7
16.5
49
97
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
12.6
14.8
26
22
R01AD12
ATC
fluticasone furoate; nasal
2.6
14.4
142
725
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
4.4
13.6
51
130
SPAT1260
SPAT
Consultation of another employee
3.1
13.3
79
294
SPAT1312
SPAT
General health counselling
2.5
13.2
135
698
WX320
NOMESCO Finland
Spinalanesthesy
2.8
13.2
96
408
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
5.9
12.9
36
66
SPAT1263
SPAT
Sampling
2.3
12.3
161
934
M01AB05
ATC
diclofenac; systemic, rectal
2.3
12.2
266
1946
9254
FHL
Arthrotomy (includes biopsy, revision, loose removal, fixation, and similar procedures)
18.8
12.2
18
10
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
12.1
158
913
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.2
11.9
67
239
M01AC06
ATC
meloxicam; systemic, rectal
2.3
11.9
143
790
M03BX02
ATC
tizanidine; oral
2.2
11.8
247
1760
H02AB06
ATC
prednisolone; systemic
2.2
11.7
176
1079
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
11.7
137
748
N03AX12
ATC
gabapentin; oral
3.3
11.7
61
207
1221
FHL
Arthroscopy and meniscus surgery
7.9
11.6
26
35
M70.6
ICD-10 Finland
Trochanteric bursitis
4.3
11.5
43
109
M22.4
ICD-10 Finland
Chondromalacia patellae
6.9
11.5
28
43
M02AA07
ATC
piroxicam; topical
2.3
11.3
131
708
S83.2
ICD-10 Finland
Tear of meniscus, current
4.1
11.3
45
122
M01AX05
ATC
glucosamine; oral
2.9
11.1
74
295
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.9
11.1
46
129
A02BC02
ATC
pantoprazole; systemic
2.1
11.1
238
1692
N06AX21
ATC
duloxetine; oral
3.5
11.0
52
163
J01FA10
ATC
azithromycin; systemic
2.1
10.8
231
1626
M01AE02
ATC
naproxen; oral, rectal
2.1
10.8
219
1510
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
8.4
10.8
23
29
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.9
10.6
34
74
XX3DW
NOMESCO Finland
Time consuming IT work
3.3
10.6
54
180
M67.4
ICD-10 Finland
Ganglion
8.1
10.5
23
30
G54.0
ICD-10 Finland
Brachial plexus disorders
9.2
10.4
21
24
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
7.8
10.3
23
31
HAHOM
NOMESCO Finland
NA
13.6
10.2
17
13
A02BC01
ATC
omeprazole; systemic
2.4
10.2
103
518
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
3.2
10.2
56
195
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.6
10.1
79
345
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.3
10.0
109
566
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.9
9.9
40
110
R06.0
ICD-10 Finland
Dyspnoea
2.5
9.8
83
380
M54.5
ICD-10 Finland
Low back pain
2.2
9.7
123
683
L08
ICPC
Shoulder symptom/complaint
2.8
9.7
66
267
M54.4
ICD-10 Finland
Lumbago with sciatica
2.8
9.6
66
268
J01AA02
ATC
doxycycline; systemic
2.2
9.6
287
2266
D82
ICPC
Teeth/gum disease
2.1
9.6
141
839
M01AX17
ATC
nimesulide; oral
2.4
9.5
90
433
N02AJ06
ATC
codeine and paracetamol; systemic
2.1
9.5
145
873
R01AD08
ATC
fluticasone; nasal
2.2
9.5
115
629
SPAT1301
SPAT
No procedures
2.2
9.4
116
638
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.4
9.3
46
149
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.7
9.3
67
280
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.2
9.2
111
604
L15
ICPC
Knee symptom/complaint
2.5
8.9
73
327
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.9
8.8
55
210
M02AA10
ATC
ketoprofen; topical
2.8
8.8
59
236
M03BC51
ATC
orphenadrine, combinations; systemic
2.1
8.8
114
638
M47.82
ICD-10 Finland
Other spondylosis, cervical region
6.9
8.8
21
32
R53
ICD-10 Finland
Malaise and fatigue
2.4
8.7
77
360
SPAT1211
SPAT
Application of soft bandage
3.5
8.7
40
123
N02BE01
ATC
paracetamol; systemic, rectal
2.3
8.7
309
2558
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
5.9
8.6
23
41
XF404
NOMESCO Finland
Ambulatory ECG
3.7
8.6
37
108
WX402
NOMESCO Finland
General anaesthesia
2.4
8.6
78
369
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.8
8.5
35
98
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
8.5
141
869
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.1
8.5
32
83
M09AX01
ATC
hyaluronic acid; parenteral
6.1
8.4
22
38
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
5.0
8.4
26
55
S06.0
ICD-10 Finland
Concussion
3.4
8.4
40
127
M79.7
ICD-10 Finland
Fibromyalgia
11.1
8.4
15
14
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
+∞
8.4
8
*
J01FA09
ATC
clarithromycin; systemic
2.0
8.3
125
738
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.3
8.3
42
139
N06AA09
ATC
amitriptyline; systemic
3.4
8.3
40
128
M01AE03
ATC
ketoprofen; systemic, rectal
2.0
8.2
132
803
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
17.6
8.1
12
7
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.9
8.1
51
196
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
5.0
8.1
25
53
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.3
8.0
85
432
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
13.4
7.9
13
10
M79.1
ICD-10 Finland
Myalgia
2.8
7.9
50
193
J01DB01
ATC
cefalexin; oral
2.1
7.9
300
2481
R51.80
ICD-10 Finland
Headache
2.6
7.8
58
243
NBG00
NOMESCO Finland
Plastic operation on acromioclavicular joint
45.9
7.7
9
*
N05BA01
ATC
diazepam; systemic, rectal
2.8
7.7
51
201
9242
FHL
Other reconstruction or plastic surgery of shoulder joint (including ac joint)
25.6
7.6
10
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.7
7.5
31
88
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.9
7.4
165
1116
M01AB08
ATC
etodolac; oral
3.7
7.4
31
89
M01AE01
ATC
ibuprofen; systemic, rectal
2.5
7.4
336
2951
L13
ICPC
Hip symptom/complaint
2.8
7.4
49
193
JN3AD
NOMESCO Finland
Abdominal CT examination
3.3
7.4
36
117
XA402
NOMESCO Finland
ENMG
9.6
7.3
14
15
X59
ICD-10 Finland
Exposure to unspecified factor
2.3
7.3
70
336
SPAT1310
SPAT
Counselling related to known health issue
2.0
7.3
112
664
7261X
ICD-9 Finland
Peripheral enthesopathies and allied syndromes, Rotator cuff syndrome of shoulder and allied disorders[MUU TAI TARKEMMIN MÄÄRITTELEM KIERTÄJÄKALVOSINSDR]
+∞
7.3
7
*
9311
FHL
Knee cleansing surgery (synovectomy, debridement)
+∞
7.3
7
*
WX723
NOMESCO Finland
CPAP therapy
4.0
7.2
28
75
M54.2
ICD-10 Finland
Cervicalgia
3.6
7.2
31
91
UDC00
NOMESCO Finland
Ear microscopy
3.2
7.1
36
120
1223
FHL
Arthroscopy and articular cartilage surgery
10.3
7.1
13
13
NH3EA
NOMESCO Finland
Feet X-ray examination with load
7.2
7.1
16
23
R52.2
ICD-10 Finland
Other chronic pain
7.2
7.1
16
23
R06AE07
ATC
cetirizine; oral
1.8
7.1
160
1087
M01AH01
ATC
celecoxib; oral (coxibs)
2.4
7.0
62
288
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.9
7.0
41
151
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.6
7.0
30
88
Z01.9
ICD-10 Finland
Special examination, unspecified
3.8
6.9
28
78
M23
ICD-10 Finland
Internal derangement of knee
8.5
6.9
14
17
M48.0
ICD-10 Finland
Spinal stenosis
3.2
6.8
34
113
R03AC02
ATC
salbutamol; inhalant
1.8
6.8
184
1319
SPAT1097
SPAT
Recording of ECG
2.6
6.8
50
212
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
6.7
96
550
A02BA02
ATC
ranitidine; systemic
2.3
6.7
66
321
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.8
6.7
140
919
R05
ICPC
Cough
2.1
6.6
80
431
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
7.0
6.6
15
22
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.4
6.5
57
264
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
5.9
6.5
17
30
M01AH02
ATC
rofecoxib; oral
2.7
6.5
44
175
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
14.6
6.4
10
7
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
14.6
6.4
10
7
WX110
NOMESCO Finland
Local anesthesy
1.8
6.4
251
2001
SPAT1377
SPAT
Polysomnography
4.3
6.4
22
53
G47.3
ICD-10 Finland
Sleep apnoea
2.1
6.4
80
434
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.8
6.4
41
160
M65.3
ICD-10 Finland
Trigger finger
9.5
6.3
12
13
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.0
6.3
36
130
XX9TE
NOMESCO Finland
Compementary ultrasound examination
18.4
6.3
9
5
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
6.3
83
461
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.6
6.3
27
80
N05CF01
ATC
zopiclone; oral
1.9
6.3
104
627
7290A
ICD-9 Finland
Other disorders of soft tissues, Rheumatism, unspecified and fibrositis
+∞
6.3
6
*
SPAT1281
SPAT
Other administrative function
2.9
6.3
36
131
NGF20
NOMESCO Finland
Operation for osteochondritis of knee, open
27.1
6.2
8
*
M89.0
ICD-10 Finland
Algoneurodystrophy
27.1
6.2
8
*
M23.4
ICD-10 Finland
Loose body in knee
27.1
6.2
8
*
7188E
ICD-9 Finland
Other derangement of joint, Other joint derangement, not elsewhere classified[MB ARTICULI, LIGAM ET CARTILAG AL DEF,LONKKANIVEL]
27.1
6.2
8
*
H02BX01
ATC
methylprednisolone, combinations; systemic
4.8
6.2
19
41
NG1DA
NOMESCO Finland
X-ray of knees
7.9
6.2
13
17
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
4.5
6.1
20
46
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
121
262
6.26
56.65
3.5
2.9
—
—
—
0
0
93
205
5.66
41.80
4.4
3.5
1.2
1.2
mmol/l
0.45
84
185
184
716
3.99
39.50
3.9
3.2
0.0
0.0
estimate
0.50
109
261
41
47
9.64
33.39
3.8
3.3
57.8
55.1
%
0.51
41
47
39
44
9.74
32.11
3.8
3.2
3.9
4.2
e9/l
0.40
39
44
34
34
10.87
30.47
2.0
1.9
1.6
1.7
mmol/l
0.24
34
34
38
47
8.86
29.11
2.6
2.4
16.4
16.5
%
0.03
14
29
205
1119
2.77
21.48
3.8
3.0
—
—
—
0
0
34
57
6.44
19.85
1.6
1.7
—
—
—
0
0
180
973
2.59
18.49
4.5
3.0
14.4
27.9
ng/l
3.42
116
597
226
1412
2.44
16.32
3.7
2.9
0.0
0.0
estimate
0.00
112
270
228
1434
2.44
16.17
3.7
3.0
0.0
0.0
estimate
0.00
111
260
225
1419
2.40
15.68
4.3
4.1
0.0
0.0
estimate
0.50
111
269
15
12
12.96
15.22
1.9
1.6
—
—
—
0
0
15
13
11.96
14.50
1.9
1.5
—
—
—
0
0
295
2159
2.54
13.88
5.5
3.5
11.1
10.5
mm/h
0.34
267
1997
15
14
11.11
13.83
1.9
1.5
—
—
—
0
0
16
19
8.74
12.45
2.1
1.5
—
—
—
0
0
93
438
2.48
12.02
1.3
1.2
1.3
16.3
u/ml
2.59
44
177
131
723
2.23
11.71
2.3
2.1
110.8
274.6
u/l
1.11
115
680
152
906
2.12
11.05
2.6
3.6
2.4
2.4
mmol/l
0.17
140
822
107
555
2.28
11.02
2.1
1.7
236905180.4
8299171.9
pmol/l
0.71
84
482
93
462
2.33
10.55
1.3
1.2
25.2
34.6
iu/ml
0.52
28
141
14
18
8.03
10.20
1.4
1.1
11.9
0.1
u/ml
—
5
7
125
723
2.08
9.61
2.7
2.6
1.1
0.4
e6/l
0.41
97
531
17
30
5.88
9.35
1.7
2.1
31.6
34.3
pg
1.48
17
30
18
36
5.20
8.70
2.1
1.7
—
—
—
0
0
16
29
5.71
8.57
2.1
1.8
—
—
—
0
0
285
2262
1.99
8.07
9.7
7.0
74.9
76.1
u/l
0.26
269
2127
166
1123
1.84
7.69
5.0
5.1
35.6
36.3
g/l
0.92
151
1063
145
945
1.85
7.54
3.1
2.7
—
—
—
0
0
228
1705
1.82
7.53
9.4
9.7
4.3
4.0
e9/l
0.69
211
1501
17
37
4.76
7.47
1.9
1.6
—
—
—
0
0
294
2385
1.97
7.46
4.8
3.8
14.9
14.6
pmol/l
0.85
262
2185
18
42
4.45
7.29
2.1
1.9
—
—
—
0
0
324
2731
2.14
7.23
18.4
14.2
13.5
13.6
%
0.51
318
2678
355
3126
2.64
6.83
18.4
11.1
16.1
22.7
mg/l
4.19
302
2389
102
616
1.89
6.60
2.2
1.7
0.6
1.1
mg/l
5.63
83
470
345
3012
2.34
6.55
15.6
10.1
86.5
85.5
ml/min/173m2
0.47
313
2442
16
38
4.35
6.34
1.9
1.6
—
—
—
0
0
17
44
4.00
6.05
1.9
1.5
—
—
—
0
0
20
59
3.52
5.94
1.3
1.3
—
—
—
0
0
163
1170
1.68
5.69
6.5
6.4
1.2
1.2
mmol/l
0.16
149
1083
17
48
3.66
5.38
2.0
1.7
—
—
—
0
0
71
406
1.92
5.35
2.4
1.7
1503.3
1193.0
nmol/l
2.15
52
311
179
1336
1.63
5.25
4.5
4.0
—
—
—
0
0
77
455
1.86
5.24
3.2
3.0
2.4
2.4
mmol/l
0.19
66
411
125
854
1.68
5.16
2.8
2.3
50.7
58.2
u/l
1.88
109
801
19
63
3.12
4.74
2.1
1.9
—
—
—
0
0
44
227
2.06
4.42
1.1
1.3
66.9
151.2
iu/ml
1.50
13
101
353
3215
2.12
4.33
17.3
12.7
4.0
4.0
mmol/l
1.64
346
3117
352
3204
2.09
4.30
17.2
12.6
139.6
139.7
mmol/l
0.32
344
3113
106
723
1.64
4.30
2.3
2.5
331.4
10065.1
umol/l
4.21
86
636
19
67
2.93
4.29
2.1
1.8
—
—
—
0
0
12
31
3.96
4.29
1.0
1.1
—
—
—
0
0
22
87
2.62
4.04
1.7
1.3
1.1
1.2
g/l
0.94
22
80
323
2885
1.72
3.87
5.4
4.4
2.0
1.9
mu/l
0.23
294
2655
63
384
1.77
3.84
2.1
1.8
—
—
—
0
0
21
85
2.55
3.70
1.7
1.3
0.2
0.2
g/l
0.84
21
79
368
3440
2.42
3.67
12.5
8.9
26.4
27.0
u/l
0.32
356
3333
14
47
3.05
3.44
2.8
2.1
128.7
132.7
g/l
0.17
14
38
93
657
1.55
3.18
1.4
1.3
0.6
1.9
u/ml
1.32
46
189
90
633
1.55
3.13
2.5
2.0
3.3
2.9
mg/l
0.97
72
542
164
1308
1.44
3.06
6.3
7.3
1.2
1.2
mmol/l
0.17
92
1117
40
230
1.82
2.97
2.9
2.0
13.8
13.6
nmol/l
0.06
34
212
169
1368
1.42
2.85
3.7
2.6
111.5
102.9
ug/l
0.29
149
1273
19
85
2.30
2.75
2.3
1.6
—
—
—
0
0
176
1445
1.40
2.70
8.1
6.4
9.1
10.7
umol/l
3.49
160
1370
255
2231
1.42
2.69
3.7
2.9
43.8
45.5
u/l
0.16
233
2119
85
610
1.50
2.68
4.1
3.3
859.1
1147.9
ng/l
0.37
69
506
17
74
2.36
2.62
1.5
1.7
—
—
—
0
0
43
263
1.71
2.61
1.9
1.8
—
—
—
0
0
6
11
5.52
2.55
4.2
5.2
—
—
—
0
0
16
69
2.38
2.52
3.4
3.7
17.5
33.1
mg/l
—
6
56
15
63
2.44
2.49
1.7
1.5
383.7
436.5
mg/l
0.33
15
58
56
372
1.59
2.49
3.4
2.3
2.4
2.4
g/l
0.01
51
347
17
342
0.47
2.43
3.3
4.0
34.2
31.5
%
0.58
12
234
9
27
3.39
2.40
1.6
1.3
—
—
—
0
0
18
84
2.20
2.38
1.9
1.6
—
0.0
—
0
16
42
264
1.66
2.32
1.8
1.7
—
—
—
0
0
14
61
2.34
2.17
1.2
1.6
—
—
—
0
0
14
61
2.34
2.17
1.1
1.3
456.8
237.6
u/ml
—
8
36
15
68
2.25
2.14
3.5
3.7
—
1.2
—
0
8
24
131
1.89
2.13
1.5
1.3
365.3
307.2
mu/l
0.27
18
119
141
1152
1.35
2.11
2.7
2.2
80.2
73.8
nmol/l
2.04
132
1060
249
2216
1.35
2.08
3.0
3.2
—
—
—
0
0
15
69
2.22
2.07
3.6
3.7
38.3
58.9
mg/l
—
5
56
103
805
1.38
2.03
1.6
1.6
1.4
1.4
mmol/l
0.05
62
683
8
26
3.12
2.02
1.1
1.3
—
—
—
0
0
14
64
2.23
1.96
2.1
2.0
169.7
140.1
ug/min
—
9
38
15
71
2.16
1.95
2.9
2.6
26.0
25.1
mmol/l
0.45
15
60
8
27
3.00
1.94
1.1
1.1
—
—
—
0
0
7
22
3.22
1.89
1.1
1.0
—
—
—
0
0
8
28
2.90
1.87
1.1
1.1
—
—
—
0
0
311
2887
1.39
1.83
5.3
4.9
38.7
39.1
mmol/mol
0.29
270
2710
11
47
2.38
1.79
6.2
5.0
126.9
180.2
u/ml
0.17
11
42
48
333
1.50
1.79
3.7
2.4
24.4
24.1
%
0.04
43
287
80
613
1.38
1.76
1.8
1.5
—
—
—
0
0
6
18
3.37
1.75
1.5
2.2
—
—
—
0
0
5
13
3.88
1.72
1.2
1.1
1703.4
1439.2
miu/ml
—
5
13
55
396
1.45
1.71
3.5
2.3
13.9
13.8
umol/l
0.03
49
371
48
660
0.69
1.64
2.6
2.2
—
—
—
0
0
14
71
2.01
1.56
1.9
2.5
—
—
—
0
0
27
170
1.63
1.53
1.3
1.4
22.9
26.3
iu/l
0.25
21
155
7
27
2.62
1.52
1.1
1.0
—
—
—
0
0
7
27
2.62
1.52
1.1
1.1
—
—
—
0
0
13
66
2.00
1.45
1.1
1.3
—
—
—
0
0
6
22
2.75
1.44
2.8
1.9
—
—
—
0
0
16
89
1.83
1.39
1.3
1.6
—
—
—
0
0
5
17
2.97
1.36
1.6
1.4
1.6
2.0
mmol/l
—
5
17
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
17
2.97
1.36
1.4
2.8
153.6
125.5
%
—
5
17
18
107
1.72
1.28
2.0
2.0
153.1
2247.8
u/l
—
9
48
8
37
2.19
1.22
1.0
1.2
171.1
333.9
pmol/l
—
8
31
26
379
0.66
1.22
1.7
1.7
—
—
—
0
0
36
490
0.71
1.18
3.5
3.5
27.7
339.9
ng/l
3.37
24
357
5
20
2.52
1.15
1.6
4.4
—
—
—
0
0
25
168
1.52
1.13
1.5
1.7
—
—
—
0
0
32
229
1.43
1.08
1.7
2.5
69.4
70.2
ml/min/173m2
0.03
16
88
9
46
1.98
1.04
1.2
1.1
—
—
—
0
0
11
60
1.86
1.04
1.7
1.5
—
—
—
0
0
9
49
1.86
0.99
1.1
1.2
—
1.0
—
0
5
27
191
1.44
0.97
1.5
1.6
—
—
—
0
0
10
54
1.87
0.97
1.0
1.2
—
—
—
0
0
12
70
1.74
0.93
2.8
4.6
1.2
1.3
mmol/l
0.09
12
70
118
1033
1.20
0.91
4.8
3.4
32.0
31.4
u/l
0.06
107
993
23
161
1.46
0.89
1.1
1.0
—
—
—
0
0
6
30
2.02
0.87
1.0
1.1
—
—
—
0
0
323
3104
1.25
0.85
4.1
3.9
5.9
5.8
mmol/l
0.19
292
2874
95
824
1.20
0.81
5.1
4.0
12.8
10.1
mg/mmol
0.14
54
529
7
125
0.55
0.79
1.0
1.7
—
—
—
0
0
0
26
0.00
0.78
0.0
1.3
—
—
—
0
0
11
67
1.66
0.76
2.0
1.2
—
—
—
0
0
50
408
1.26
0.75
2.5
2.3
29.8
29.5
s
0.15
50
396
323
3116
1.22
0.74
3.8
3.6
1.4
1.3
mmol/l
1.43
290
2928
53
437
1.25
0.74
2.0
1.8
1.4
1.4
%
0.06
44
388
61
720
0.82
0.72
3.5
3.8
17.2
21.2
%
1.42
28
296
18
126
1.45
0.71
1.7
1.7
—
—
—
0
0
33
417
0.77
0.70
2.8
2.6
3.3
2.6
e6/l
0.19
16
223
7
41
1.72
0.70
2.3
1.6
—
—
—
0
0
21
153
1.39
0.68
4.2
3.6
2.7
1.8
mmol/l
0.76
15
116
12
178
0.66
0.66
1.8
1.8
—
—
—
0
0
5
29
1.73
0.64
2.2
3.9
23.2
58.7
u/ml
—
5
29
8
49
1.65
0.62
1.4
1.1
—
—
—
0
0
8
51
1.58
0.61
1.4
1.8
—
—
—
0
0
0
20
0.00
0.60
0.0
9.3
—
53.5
—
0
8
17
231
0.72
0.60
1.6
1.9
—
—
—
0
0
97
868
1.16
0.58
4.5
4.2
2.1
2.4
ug/l
0.14
83
794
6
37
1.63
0.56
1.0
1.1
—
—
—
0
0
12
82
1.48
0.55
1.3
1.1
—
—
—
0
0
46
390
1.20
0.52
2.1
1.9
—
—
—
0
0
18
135
1.35
0.52
1.3
1.5
—
—
—
0
0
12
84
1.44
0.50
1.3
1.3
—
—
—
0
0
7
106
0.65
0.49
2.4
2.0
—
—
—
0
0
0
15
0.00
0.41
0.0
4.7
—
109.9
—
0
15
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
18
141
1.29
0.41
5.6
11.2
26.1
24.7
mmol/l
0.98
18
132
0
17
0.00
0.40
0.0
1.7
—
—
—
0
0
0
17
0.00
0.40
0.0
1.7
—
—
—
0
0
0
17
0.00
0.40
0.0
1.7
—
—
—
0
0
0
17
0.00
0.40
0.0
1.7
—
—
—
0
0
5
37
1.36
0.37
1.0
1.4
—
—
—
0
0
67
605
1.13
0.37
1.4
1.4
19.3
21.0
nmol/l
0.31
56
519
330
3236
1.13
0.35
4.3
4.0
4.8
4.8
mmol/l
0.24
298
3064
49
435
1.14
0.35
2.2
2.0
—
—
—
0
0
334
3282
1.13
0.32
4.6
4.4
2.9
2.9
mmol/l
0.01
302
3080
328
3221
1.12
0.31
4.3
4.0
1.5
1.5
mmol/l
0.04
294
3027
7
98
0.71
0.31
2.0
1.8
—
—
—
0
0
311
3052
1.10
0.27
12.8
12.3
41.1
40.7
%
0.50
205
2375
40
445
0.89
0.26
2.1
2.4
1.9
1.0
e6/l
0.51
21
251
16
132
1.22
0.26
1.6
1.3
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
35
315
1.12
0.22
9.0
5.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
61.5
—
0
12
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
49
530
0.91
0.20
2.7
2.7
0.6
0.7
ug/l
1.36
30
313
6
53
1.13
0.19
2.5
1.5
—
—
—
0
0
33
302
1.10
0.16
4.0
2.7
5.6
6.8
umol/l
0.37
23
259
106
1023
1.05
0.14
1.7
1.8
92.2
94.2
pmol/l
0.19
61
561
5
48
1.04
0.09
2.6
1.7
12.6
13.0
%
—
5
48
17
155
1.10
0.09
1.1
1.3
—
—
—
0
0
13
144
0.90
0.08
3.3
9.7
0.8
0.7
%
0.62
13
144
13
144
0.90
0.08
3.3
9.4
1.4
1.5
%
0.04
13
144
16
146
1.10
0.08
3.0
2.4
0.0
0.2
e6/l
1.83
16
137
5
65
0.77
0.08
1.2
1.8
0.8
0.8
nmol/l
—
5
53
11
123
0.89
0.08
1.1
1.4
197.6
254.7
miu/ml
—
6
61
21
196
1.08
0.07
2.8
4.3
78.4
79.6
ng/l
0.03
15
182
7
80
0.87
0.07
1.0
1.1
—
—
—
0
0
8
94
0.85
0.06
1.8
1.6
—
—
—
0
0
12
132
0.91
0.06
1.2
1.5
—
—
—
0
0
9
105
0.85
0.06
1.8
1.6
—
—
—
0
0
11
121
0.91
0.06
1.5
1.5
—
—
—
0
0
13
140
0.93
0.04
3.4
10.0
92.1
94.0
%
0.31
13
140
26
271
0.96
0.04
3.8
10.3
2.2
1.4
mmol/l
0.98
21
219
60
589
1.02
0.03
1.6
1.5
—
—
—
0
0
12
112
1.07
0.03
1.4
1.4
—
—
—
0
0
12
112
1.07
0.03
1.4
1.4
—
—
—
0
0
12
113
1.06
0.02
1.4
1.4
—
—
—
0
0
12
113
1.06
0.02
1.4
1.4
—
—
—
0
0
12
127
0.94
0.01
3.7
2.4
1.2
1.2
%
0.02
12
127
5
55
0.91
0.00
1.0
1.7
—
—
—
0
0
6
63
0.95
0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
79
0.88
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
57.5
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
8
85
0.94
0.00
1.5
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_FATPADHYPERTROPHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FATPADHYPERTROPHY | 1.243 [0.99, 1.57] | 0.065 |
| Birth year | 0.993 [0.98, 1.0] | 0.123 |
During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 968 females with M13_FATPADHYPERTROPHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FATPADHYPERTROPHY | 1.002 [0.78, 1.29] | 0.987 |
| Birth year | 0.99 [0.98, 1.0] | 0.092 |
During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 711 males with M13_FATPADHYPERTROPHY died.
Mortality risk
Mortality risk for people of age
years, who have M13_FATPADHYPERTROPHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.239% |
| 5 | 0.548% | 1.293% |
| 10 | 1.615% | 3.128% |
| 15 | 3.274% | 6.069% |
| 20 | 5.57% | 10.718% |
Relationships between endpoints
↥Index endpoint: M13_FATPADHYPERTROPHY – Hypertrophy of (infrapatellar) fat pad
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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