Risteys · M13_FATPADHYPERTROPHY

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M79.4 Hospital discharge: ICD-9 — 7293A Cause of death: ICD-10 — M79.4 Cause of death: ICD-9 — 7293A 2 out of 7 registries used, show all original rules.	387
4. Check minimum number of events None	387
5. Include endpoints None	387
6. Filter based on genotype QC (FinnGen only)	387

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2650	1415	1223
Only index persons	2524	1364	1160
Unadjusted period prevalence (%)
Whole population	0.04	0.04	0.03
Only index persons	0.05	0.05	0.04
Median age at first event (years)
Whole population	38.04	39.91	35.86
Only index persons	37.48	39.43	35.19

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	387	232	155
Unadjusted period prevalence (%)	0.07	0.08	0.07
Median age at first event (years)	37.97	36.40	40.32

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
369: Matched controls
3689

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M79.4

ICD-10 Finland

Hypertrophy of (infrapatellar) fat pad

+∞

309.7

252

7293A

ICD-9 Finland

Other disorders of soft tissues, Panniculitis, unspecified[LIPOSYNOVITIS INFRAPATELLARIS (MORBUS HOFFA)]

+∞

131.2

118

NGF00

NOMESCO Finland

Excision of plica of synovy of knee

67.9

66.9

NGF25

NOMESCO Finland

Operation for osteochondritis of knee, arthroscopic

14.5

53.7

M23.2

ICD-10 Finland

Derangement of meniscus due to old tear or injury

6.9

35.8

183

1225

FHL

Arthroscopy and other therapeutic procedure

23.8

33.6

M23.8

ICD-10 Finland

Other internal derangements of knee

14.8

32.9

NGF35

NOMESCO Finland

Plastic operation of joint cartilage of knee

13.9

29.3

M79.6

ICD-10 Finland

Pain in limb

3.9

28.6

150

550

NGD05

NOMESCO Finland

Partial excision of meniscus of knee, arthroscopic

5.3

26.1

201

M25.5

ICD-10 Finland

Pain in joint

3.7

25.9

144

543

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

3.2

25.0

207

1047

1222

FHL

Arthroscopy and synovial surgery

33.6

24.1

M01AH05

ATC

etoricoxib; oral

3.1

22.9

255

1544

M17.1

ICD-10 Finland

Other primary gonarthrosis

4.2

22.2

281

N02AX02

ATC

tramadol; systemic, rectal

3.0

21.1

172

829

M75.1

ICD-10 Finland

Rotator cuff syndrome

4.3

21.1

242

NGF15

NOMESCO Finland

Total synovectomy of knee, arthroscopic

28.9

20.3

N03AX16

ATC

pregabalin; oral

3.6

19.9

104

360

1220

FHL

Arthroscopy

8.2

19.4

SPAT1153

SPAT

Removal of sutures

3.0

18.5

136

601

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

3.1

17.8

120

498

M79.0

ICD-10 Finland

Rheumatism, unspecified

38.8

17.8

SPAT1249

SPAT

Treatment-related counselling outside office

2.7

17.6

176

933

NBG15

NOMESCO Finland

Acromioplastia, arthroscopic

25.5

17.5

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

5.7

16.5

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

12.6

14.8

R01AD12

ATC

fluticasone furoate; nasal

2.6

14.4

142

725

M23.9

ICD-10 Finland

Internal derangement of knee, unspecified

4.4

13.6

130

SPAT1260

SPAT

Consultation of another employee

3.1

13.3

294

SPAT1312

SPAT

General health counselling

2.5

13.2

135

698

WX320

NOMESCO Finland

Spinalanesthesy

2.8

13.2

408

NGA30

NOMESCO Finland

Exploration of knee joint, arthroscopic

5.9

12.9

SPAT1263

SPAT

Sampling

2.3

12.3

161

934

M01AB05

ATC

diclofenac; systemic, rectal

2.3

12.2

266

1946

9254

FHL

Arthrotomy (includes biopsy, revision, loose removal, fixation, and similar procedures)

18.8

12.2

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.3

12.1

158

913

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.2

11.9

239

M01AC06

ATC

meloxicam; systemic, rectal

2.3

11.9

143

790

M03BX02

ATC

tizanidine; oral

2.2

11.8

247

1760

H02AB06

ATC

prednisolone; systemic

2.2

11.7

176

1079

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.3

11.7

137

748

N03AX12

ATC

gabapentin; oral

3.3

11.7

207

1221

FHL

Arthroscopy and meniscus surgery

7.9

11.6

M70.6

ICD-10 Finland

Trochanteric bursitis

4.3

11.5

109

M22.4

ICD-10 Finland

Chondromalacia patellae

6.9

11.5

M02AA07

ATC

piroxicam; topical

2.3

11.3

131

708

S83.2

ICD-10 Finland

Tear of meniscus, current

4.1

11.3

122

M01AX05

ATC

glucosamine; oral

2.9

11.1

295

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

3.9

11.1

129

A02BC02

ATC

pantoprazole; systemic

2.1

11.1

238

1692

N06AX21

ATC

duloxetine; oral

3.5

11.0

163

J01FA10

ATC

azithromycin; systemic

2.1

10.8

231

1626

M01AE02

ATC

naproxen; oral, rectal

2.1

10.8

219

1510

7170A

ICD-9 Finland

Internal derangement of knee, Old bucket handle tear of medial meniscus

8.4

10.8

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

4.9

10.6

XX3DW

NOMESCO Finland

Time consuming IT work

3.3

10.6

180

M67.4

ICD-10 Finland

Ganglion

8.1

10.5

G54.0

ICD-10 Finland

Brachial plexus disorders

9.2

10.4

Z96.6

ICD-10 Finland

Presence of orthopaedic joint implants

7.8

10.3

HAHOM

NOMESCO Finland

13.6

10.2

A02BC01

ATC

omeprazole; systemic

2.4

10.2

103

518

LX1AE

NOMESCO Finland

Gynecological ultrasound examination as part of clinical examination

3.2

10.2

195

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.6

10.1

345

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

2.3

10.0

109

566

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

3.9

9.9

110

R06.0

ICD-10 Finland

Dyspnoea

2.5

9.8

380

M54.5

ICD-10 Finland

Low back pain

2.2

9.7

123

683

L08

ICPC

Shoulder symptom/complaint

2.8

9.7

267

M54.4

ICD-10 Finland

Lumbago with sciatica

2.8

9.6

268

J01AA02

ATC

doxycycline; systemic

2.2

9.6

287

2266

D82

ICPC

Teeth/gum disease

2.1

9.6

141

839

M01AX17

ATC

nimesulide; oral

2.4

9.5

433

N02AJ06

ATC

codeine and paracetamol; systemic

2.1

9.5

145

873

R01AD08

ATC

fluticasone; nasal

2.2

9.5

115

629

SPAT1301

SPAT

No procedures

2.2

9.4

116

638

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

3.4

9.3

149

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

2.7

9.3

280

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

2.2

9.2

111

604

L15

ICPC

Knee symptom/complaint

2.5

8.9

327

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

2.9

8.8

210

M02AA10

ATC

ketoprofen; topical

2.8

8.8

236

M03BC51

ATC

orphenadrine, combinations; systemic

2.1

8.8

114

638

M47.82

ICD-10 Finland

Other spondylosis, cervical region

6.9

8.8

R53

ICD-10 Finland

Malaise and fatigue

2.4

8.7

360

SPAT1211

SPAT

Application of soft bandage

3.5

8.7

123

N02BE01

ATC

paracetamol; systemic, rectal

2.3

8.7

309

2558

M75.0

ICD-10 Finland

Adhesive capsulitis of shoulder

5.9

8.6

XF404

NOMESCO Finland

Ambulatory ECG

3.7

8.6

108

WX402

NOMESCO Finland

General anaesthesia

2.4

8.6

369

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

3.8

8.5

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.0

8.5

141

869

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

4.1

8.5

M09AX01

ATC

hyaluronic acid; parenteral

6.1

8.4

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

5.0

8.4

S06.0

ICD-10 Finland

Concussion

3.4

8.4

127

M79.7

ICD-10 Finland

Fibromyalgia

11.1

8.4

NDM40

NOMESCO Finland

Discission of sheath of tendon of wrist or hand

+∞

8.4

J01FA09

ATC

clarithromycin; systemic

2.0

8.3

125

738

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

3.3

8.3

139

N06AA09

ATC

amitriptyline; systemic

3.4

8.3

128

M01AE03

ATC

ketoprofen; systemic, rectal

2.0

8.2

132

803

M79.2

ICD-10 Finland

Neuralgia and neuritis, unspecified

17.6

8.1

G56.0

ICD-10 Finland

Carpal tunnel syndrome

2.9

8.1

196

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

5.0

8.1

J01.0

ICD-10 Finland

Acute maxillary sinusitis

2.3

8.0

432

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

13.4

7.9

M79.1

ICD-10 Finland

Myalgia

2.8

7.9

193

J01DB01

ATC

cefalexin; oral

2.1

7.9

300

2481

R51.80

ICD-10 Finland

Headache

2.6

7.8

243

NBG00

NOMESCO Finland

Plastic operation on acromioclavicular joint

45.9

7.7

N05BA01

ATC

diazepam; systemic, rectal

2.8

7.7

201

9242

FHL

Other reconstruction or plastic surgery of shoulder joint (including ac joint)

25.6

7.6

M19.0

ICD-10 Finland

Primary arthrosis of other joints

3.7

7.5

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.9

7.4

165

1116

M01AB08

ATC

etodolac; oral

3.7

7.4

M01AE01

ATC

ibuprofen; systemic, rectal

2.5

7.4

336

2951

L13

ICPC

Hip symptom/complaint

2.8

7.4

193

JN3AD

NOMESCO Finland

Abdominal CT examination

3.3

7.4

117

XA402

NOMESCO Finland

ENMG

9.6

7.3

X59

ICD-10 Finland

Exposure to unspecified factor

2.3

7.3

336

SPAT1310

SPAT

Counselling related to known health issue

2.0

7.3

112

664

7261X

ICD-9 Finland

Peripheral enthesopathies and allied syndromes, Rotator cuff syndrome of shoulder and allied disorders[MUU TAI TARKEMMIN MÄÄRITTELEM KIERTÄJÄKALVOSINSDR]

+∞

7.3

9311

FHL

Knee cleansing surgery (synovectomy, debridement)

+∞

7.3

WX723

NOMESCO Finland

CPAP therapy

4.0

7.2

M54.2

ICD-10 Finland

Cervicalgia

3.6

7.2

UDC00

NOMESCO Finland

Ear microscopy

3.2

7.1

120

1223

FHL

Arthroscopy and articular cartilage surgery

10.3

7.1

NH3EA

NOMESCO Finland

Feet X-ray examination with load

7.2

7.1

R52.2

ICD-10 Finland

Other chronic pain

7.2

7.1

R06AE07

ATC

cetirizine; oral

1.8

7.1

160

1087

M01AH01

ATC

celecoxib; oral (coxibs)

2.4

7.0

288

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

2.9

7.0

151

WZC20

NOMESCO Finland

Multidisciplinary treatment meeting

3.6

7.0

Z01.9

ICD-10 Finland

Special examination, unspecified

3.8

6.9

M23

ICD-10 Finland

Internal derangement of knee

8.5

6.9

M48.0

ICD-10 Finland

Spinal stenosis

3.2

6.8

113

R03AC02

ATC

salbutamol; inhalant

1.8

6.8

184

1319

SPAT1097

SPAT

Recording of ECG

2.6

6.8

212

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.0

6.7

550

A02BA02

ATC

ranitidine; systemic

2.3

6.7

321

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.8

6.7

140

919

R05

ICPC

Cough

2.1

6.6

431

M03BA52

ATC

carisoprodol, combinations excl. psycholeptics; oral

7.0

6.6

R10.1

ICD-10 Finland

Pain localized to upper abdomen

2.4

6.5

264

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

5.9

6.5

M01AH02

ATC

rofecoxib; oral

2.7

6.5

175

NA1EA

NOMESCO Finland

Cervical spine X-ray examination with flexion

14.6

6.4

AA3AI

NOMESCO Finland

Cone beam CT of facial bones

14.6

6.4

WX110

NOMESCO Finland

Local anesthesy

1.8

6.4

251

2001

SPAT1377

SPAT

Polysomnography

4.3

6.4

G47.3

ICD-10 Finland

Sleep apnoea

2.1

6.4

434

M53.1

ICD-10 Finland

Cervicobrachial syndrome

2.8

6.4

160

M65.3

ICD-10 Finland

Trigger finger

9.5

6.3

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

3.0

6.3

130

XX9TE

NOMESCO Finland

Compementary ultrasound examination

18.4

6.3

R07.4

ICD-10 Finland

Chest pain, unspecified

2.0

6.3

461

UDQ12

NOMESCO Finland

Flexible laryngoscopy

3.6

6.3

N05CF01

ATC

zopiclone; oral

1.9

6.3

104

627

7290A

ICD-9 Finland

Other disorders of soft tissues, Rheumatism, unspecified and fibrositis

+∞

6.3

SPAT1281

SPAT

Other administrative function

2.9

6.3

131

NGF20

NOMESCO Finland

Operation for osteochondritis of knee, open

27.1

6.2

M89.0

ICD-10 Finland

Algoneurodystrophy

27.1

6.2

M23.4

ICD-10 Finland

Loose body in knee

27.1

6.2

7188E

ICD-9 Finland

Other derangement of joint, Other joint derangement, not elsewhere classified[MB ARTICULI, LIGAM ET CARTILAG AL DEF,LONKKANIVEL]

27.1

6.2

H02BX01

ATC

methylprednisolone, combinations; systemic

4.8

6.2

NG1DA

NOMESCO Finland

X-ray of knees

7.9

6.2

NG1BG

NOMESCO Finland

Knee and lower leg MRI examination with high intensity magnet

4.5

6.1

Mortality – FinRegistry

↥

Association

Association between endpoint M13_FATPADHYPERTROPHY and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_FATPADHYPERTROPHY	1.243 [0.99, 1.57]	0.065
Birth year	0.993 [0.98, 1.0]	0.123

During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 968 females with M13_FATPADHYPERTROPHY died.

Males

Parameter	HR [95% CI]	p-value
M13_FATPADHYPERTROPHY	1.002 [0.78, 1.29]	0.987
Birth year	0.99 [0.98, 1.0]	0.092

During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 711 males with M13_FATPADHYPERTROPHY died.

Mortality risk

Mortality risk for people of age

years, who have M13_FATPADHYPERTROPHY.

N-year risk	Females	Males
1	0.089%	0.239%
5	0.548%	1.293%
10	1.615%	3.128%
15	3.274%	6.069%
20	5.57%	10.718%

Relationships between endpoints

↥

Index endpoint: M13_FATPADHYPERTROPHY – Hypertrophy of (infrapatellar) fat pad

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	M13_FATPADHYPERTROPHY
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M794
HD_ICD_9	7293A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M794
COD_ICD_9	7293A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Hypertrophy of (infrapatellar) fat pad

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints