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Other specified/unspecified necrotizing vasculopathies

EFO MESH Endpoint Browser PheWeb

M13_NECROVASCNAS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M31.8, M31.9
  • Hospital discharge: ICD-9 — 447[5-6]
  • Hospital discharge: ICD-8 — 4469
  • Cause of death: ICD-10 — M31.8, M31.9
  • Cause of death: ICD-9 — 447[5-6]
  • Cause of death: ICD-8 — 4469

2 out of 7 registries used, show all original rules.

507

4. Check minimum number of events

None

507

5. Include endpoints

None

507

6. Filter based on genotype QC (FinnGen only)

494

Control definitions (FinnGen only)

Control exclude
M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3624 1976 1609
Only index persons 2728 1510 1218
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.04
Only index persons 0.05 0.06 0.05
Median age at first event (years)
Whole population 61.78 62.38 60.96
Only index persons 59.20 59.37 58.98

-FinnGen-

Key figures

All Female Male
Number of individuals 494 269 225
Unadjusted period prevalence (%) 0.10 0.10 0.10
Median age at first event (years) 57.51 54.72 60.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
507
Matched controls
5070
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
307.7
293
*
L04AX01
ATC
azathioprine; systemic
34.7
236.4
161
67
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
153.1
139
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
10.8
140.7
194
275
L04AA06
ATC
mycophenolic acid; systemic
45.4
123.0
74
19
H02AB06
ATC
prednisolone; systemic
6.8
82.6
394
1719
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
81.5
76
*
M05BA04
ATC
alendronic acid; oral
7.4
75.4
130
227
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.1
71.9
310
1202
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
10.5
65.1
77
85
4476A
ICD-9 Finland
Other disorders of arteries and arterioles, Arteritis, unspecified
+∞
65.0
61
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
7.9
65.0
100
153
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
9.2
62.3
82
104
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
26.0
60.8
43
18
L04AX03
ATC
methotrexate; systemic
6.3
59.0
117
232
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
16.6
58.7
51
34
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.3
56.0
91
147
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.1
51.2
131
324
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
13.5
50.3
49
40
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
49.8
47
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
46.5
343
1771
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
9.3
45.1
57
68
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
6.9
44.8
75
124
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
164.2
43.5
45
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.9
39.7
78
151
R50.9
ICD-10 Finland
Fever, unspecified
4.1
39.5
134
407
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.4
39.2
214
890
M35.3
ICD-10 Finland
Polymyalgia rheumatica
12.0
38.4
40
36
H02AB07
ATC
prednisone; oral
4.0
37.7
133
414
PAW37
NOMESCO Finland
Biopsy of temporal artery
394.9
37.5
37
*
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
10.8
36.7
41
41
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
7.5
35.9
54
79
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
35.9
34
*
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
35.9
34
*
TK800
NOMESCO Finland
Hemodialysis
10.8
35.8
40
40
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.4
35.8
104
280
A11CC03
ATC
alfacalcidol; systemic
10.3
35.5
41
43
N18.8
ICD-10 Finland
Other chronic renal failure
10.8
34.9
39
39
44698
ICD-8 Finland
Polyarteritis nodosa and allied conditions, Other
+∞
34.8
33
*
A12AA04
ATC
calcium carbonate; oral
13.5
34.3
33
26
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
93.9
32.2
35
*
H02AB04
ATC
methylprednisolone; systemic
3.6
31.9
130
442
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.6
31.5
64
127
C03CA01
ATC
furosemide; systemic
3.0
31.4
237
1158
L01AA01
ATC
cyclophosphamide; systemic
74.9
31.3
35
5
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
30.5
29
*
J01MA12
ATC
levofloxacin; systemic
3.2
29.6
154
607
KA1AE
NOMESCO Finland
Kidney ultrasound examination
8.8
29.5
38
46
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.6
29.2
114
375
B03XA02
ATC
darbepoetin alfa; parenteral
10.3
28.8
33
34
P01BA02
ATC
hydroxychloroquine; oral
4.5
28.3
76
191
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.9
27.8
94
280
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
27.3
26
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.8
26.6
64
147
ZX120
NOMESCO Finland
Intravenous
3.9
26.4
88
259
L01BA01
ATC
methotrexate; systemic
6.7
26.1
43
69
TGC00
NOMESCO Finland
Bronchial lavation
7.0
25.9
41
63
J01MA14
ATC
moxifloxacin; systemic
3.9
25.7
84
244
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
25.2
24
*
N085, M318,
ICD-10 Finland
+∞
25.2
24
*
NHQ40
NOMESCO Finland
Amputation of toe
9.6
25.0
30
33
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.5
24.9
101
339
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.7
24.7
48
91
D69.0
ICD-10 Finland
Allergic purpura
43.9
23.9
29
7
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
251.4
23.9
24
*
J01FF01
ATC
clindamycin; systemic
2.7
23.5
187
911
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
5.2
23.2
50
104
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
6.7
23.1
38
61
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.8
22.6
143
618
M13.9
ICD-10 Finland
Arthritis, unspecified
4.1
22.4
66
177
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
21.8
158
731
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
21.7
130
544
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.4
21.3
57
142
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
218.6
20.7
21
*
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
19.9
19
*
A41.9
ICD-10 Finland
Sepsis, unspecified
5.4
19.8
41
82
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.2
19.8
57
150
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.4
19.8
78
255
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
6.0
19.7
36
64
I77.6
ICD-10 Finland
Arteritis, unspecified
207.8
19.7
20
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
7.0
19.3
30
45
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
5.5
19.2
38
73
A46
ICD-10 Finland
Erysipelas
2.8
18.8
109
446
A10AC01
ATC
insulin (human); parenteral
3.4
18.2
70
225
A02BC02
ATC
pantoprazole; systemic
2.5
18.1
382
2776
L95.8
ICD-10 Finland
Other vasculitis limited to skin
54.6
18.1
21
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.5
17.9
66
206
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
17.8
17
*
M30.0
ICD-10 Finland
Polyarteritis nodosa
+∞
17.8
17
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.6
17.7
63
192
TDM10
NOMESCO Finland
Puncture of maxillary antrum
5.4
17.7
36
71
Z49.1
ICD-10 Finland
Extracorporeal dialysis
13.8
17.7
30
23
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
17.6
183
985
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
17.7
17.6
27
16
Z94.0
ICD-10 Finland
Kidney transplant status
25.1
17.5
24
10
N18.0
ICD-10 Finland
End-stage renal disease
18.2
17.1
26
15
D64.9
ICD-10 Finland
Anaemia, unspecified
3.0
16.8
82
304
M31.6
ICD-10 Finland
Other giant cell arteritis
93.2
16.7
18
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
16.5
96
391
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
16.1
143
714
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
15.2
16.0
26
18
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.3
15.7
65
218
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
15.7
15
*
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
15.7
15
*
S97
ICPC
Chronic ulcer skin
3.4
15.5
59
188
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
25.9
14.8
20
8
C08CA05
ATC
nifedipine; systemic
3.5
14.7
53
163
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.9
14.6
74
279
WW200
NOMESCO Finland
Immunization
6.0
14.6
26
45
JN4AD
NOMESCO Finland
Body CT examination
2.9
14.5
75
286
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
14.5
94
404
H02AB09
ATC
hydrocortisone; systemic
6.4
14.3
24
39
N02AX02
ATC
tramadol; systemic, rectal
2.1
14.3
251
1630
GD1AD
NOMESCO Finland
Thorax CT examination
3.6
14.2
50
151
127
Kela drug reimbursment
Transplant complication
13.2
14.0
24
19
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
6.2
14.0
24
40
H26.3
ICD-10 Finland
Drug-induced cataract
18.2
13.9
21
12
A02BC01
ATC
omeprazole; systemic
2.2
13.9
171
970
ZXD05
NOMESCO Finland
Urgent procedure
2.1
13.9
181
1050
UJF32
NOMESCO Finland
Coloscopy
2.2
13.8
159
879
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
15.3
13.7
22
15
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
+∞
13.6
13
*
ZZA00
NOMESCO Finland
Split skin graft
4.7
13.2
31
69
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
4.8
13.2
30
65
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
23.3
13.0
18
8
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.6
12.9
44
130
B01AA03
ATC
warfarin; systemic
2.2
12.8
128
665
ZXA10
NOMESCO Finland
Bilateral
2.3
12.8
124
636
A10AB05
ATC
insulin aspart; parenteral
3.0
12.8
59
211
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.1
12.8
150
832
R04.0
ICD-10 Finland
Epistaxis
3.1
12.7
55
189
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
16.0
12.7
20
13
M05BA07
ATC
risedronic acid; oral
4.3
12.7
33
80
J45.1
ICD-10 Finland
Nonallergic asthma
3.2
12.7
54
184
M31.4
ICD-10 Finland
Aortic arch syndrome [Takayasu]
+∞
12.5
12
*
J01MA02
ATC
ciprofloxacin; systemic
2.0
12.5
221
1421
Z2446
NOMESCO Finland
Social worker
3.3
12.5
49
159
V03AE01
ATC
polystyrene sulfonate; oral
10.9
12.4
23
22
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.6
12.3
30
69
M04AA01
ATC
allopurinol; systemic
2.5
12.2
87
389
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.2
12.1
115
585
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.8
11.9
64
249
L04AA01
ATC
[U] ciclosporin
13.0
11.7
20
16
J01DB01
ATC
cefalexin; oral
2.4
11.5
426
3502
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
14.0
11.5
19
14
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
11.5
11
*
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
5.6
11.4
22
41
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
11.4
107
540
M10.9
ICD-10 Finland
Gout, unspecified
3.1
11.3
48
163
UKC02
NOMESCO Finland
Cystoscopy
2.3
11.2
103
515
N03AX16
ATC
[U] pregabalin
2.1
11.1
136
760
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
14.3
11.0
18
13
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.9
11.0
195
1241
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
12.3
10.9
19
16
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
15.9
10.9
17
11
ZX108
NOMESCO Finland
Inhalation
18.3
10.8
16
9
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
61.3
10.7
12
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.2
10.7
44
147
L88
ICPC
Rheumatoid/seropositive arthritis
4.0
10.6
31
82
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.5
10.6
26
60
DHA10
NOMESCO Finland
Biopsy of cavity of nose
11.6
10.6
19
17
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
10.6
215
1427
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
10.4
10
*
L04AD02
ATC
tacrolimus; systemic
16.5
10.4
16
10
V03AE02
ATC
sevelamer; oral
33.3
10.4
13
*
J45.8
ICD-10 Finland
Mixed asthma
4.7
10.3
24
53
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.5
10.3
68
293
205
Kela drug reimbursment
Chronic hypertension
2.0
10.3
158
955
C08CA01
ATC
amlodipine; oral
1.9
10.3
216
1446
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.1
10.2
125
697
M05BB03
ATC
alendronic acid and colecalciferol; oral
4.5
10.2
25
58
R06.0
ICD-10 Finland
Dyspnoea
1.9
10.1
156
944
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.0
10.1
47
169
A02BC03
ATC
lansoprazole; oral
1.9
10.0
167
1037
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
17.1
9.9
15
9
Z3231
NOMESCO Finland
Registered nurse
1.9
9.9
155
941
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
5.1
9.9
21
43
TQW80
NOMESCO Finland
Local dermatologic skincare
4.8
9.9
22
47
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.2
9.8
26
64
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.3
9.8
80
380
I50.9
ICD-10 Finland
Heart failure, unspecified
2.2
9.7
96
492
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
9.7
111
602
3AC01, ,
NOMESCO Finland
13.7
9.7
16
12
TPH07
NOMESCO Finland
Cathetrisation of artery
2.4
9.7
73
334
UDM02
NOMESCO Finland
Sinoscopy
5.2
9.6
20
40
L04AD01
ATC
ciclosporin; systemic
8.6
9.6
20
24
L95.0
ICD-10 Finland
Livedoid vasculitis
101.9
9.4
10
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
9.4
9
*
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
9.4
9
*
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
22.2
9.4
13
6
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
22.2
9.4
13
6
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
22.2
9.4
13
6
WX892
NOMESCO Finland
Monitored bed care
2.7
9.4
52
205
R04.2
ICD-10 Finland
Haemoptysis
3.7
9.4
30
85
XG410
NOMESCO Finland
Flow-volume spirometry
3.5
9.3
32
95
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
9.3
105
566
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.7
9.3
54
218
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
9.3
106
574
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
9.2
68
308
M05BA06
ATC
ibandronic acid; systemic
5.2
9.2
19
38
C08CA02
ATC
felodipine; oral
2.5
9.1
62
271
H04.10
ICD-10 Finland
Dry eye syndrome
2.4
9.0
65
292
TAB00
NOMESCO Finland
Lumbar puncture
3.3
8.9
34
108
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
24.5
8.9
12
5
UJF92
NOMESCO Finland
Capsular endoscopy
5.0
8.9
19
39
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
8.8
112
630
A12AA12
ATC
[U] calcium acetate
50.9
8.7
10
*
B34.9
ICD-10 Finland
Viral infection, unspecified
4.7
8.7
20
44
Z49.0
ICD-10 Finland
Preparatory care for dialysis
11.8
8.6
15
13
R60.0
ICD-10 Finland
Localized oedema
2.3
8.6
73
351
J05AB11
ATC
valaciclovir; oral
2.1
8.6
89
464
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
8.6
258
1891
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.6
8.5
50
203
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.5
8.5
29
86
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.0
8.5
39
139
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.6
8.5
51
210
AA1AD
NOMESCO Finland
CT of head and brain
1.8
8.4
153
967
137
Kela drug reimbursment
Uraemia requiring dialysis
13.0
8.4
14
11
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.3
8.4
31
97
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
8.4
8
*
N02AA05
ATC
oxycodone; systemic
2.0
8.3
108
611
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.4
8.3
62
282
J01FA06
ATC
roxithromycin; oral
1.7
8.3
211
1471
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
4.3
8.3
21
50
1XC02, ,
NOMESCO Finland
14.8
8.2
13
9
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
8.2
234
1683
A41.8
ICD-10 Finland
Other specified sepsis
4.7
8.2
19
42
A01AB10
ATC
natamycin; local oral
4.1
8.1
22
55
ZXA00
NOMESCO Finland
Right side
1.8
8.1
151
959
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
7.0
8.1
19
28
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
22.4
8.0
11
5
C09AA02
ATC
enalapril; systemic
1.9
8.0
113
657
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.8
8.0
41
155
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.8
8.0
24
65
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.6
8.0
46
185
NF1AA
NOMESCO Finland
Hip X-ray examination
2.3
8.0
60
274
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.7
7.9
43
168
R53
ICD-10 Finland
Malaise and fatigue
1.8
7.7
135
842
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
18.7
7.6
11
6
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.2
7.6
20
49
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
4.3
7.5
19
45
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
4.0
7.5
21
54
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.6
7.5
25
73
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
7.4
102
587
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.4
7.4
51
224
WW400
NOMESCO Finland
Plasmaferesis
+∞
7.3
7
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
7.3
7
*
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
7.3
7
*
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
7.3
7
*
J47
ICD-10 Finland
Bronchiectasis
4.4
7.3
18
42
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.4
7.3
18
42
QDB10, ,
SPAT
4.6
7.2
17
38
J01AA02
ATC
doxycycline; systemic
1.8
7.2
390
3288
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.4
7.2
50
220
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.5
7.1
47
202
J01CA04
ATC
amoxicillin; systemic
1.8
7.1
399
3392
XX9XE
NOMESCO Finland
Other ultrasound examination
10.2
7.1
13
13
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
4.3
7.1
18
43
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
7.1
187
1305
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.1
7.0
29
97
H65.2
ICD-10 Finland
Chronic serous otitis media
7.7
6.9
15
20
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.1
6.9
29
98
A03
ICPC
Fever
2.0
6.9
81
441
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
6.9
180
1251
NGQ20
NOMESCO Finland
Amputation of lower leg
9.5
6.8
13
14
N06AA09
ATC
amitriptyline; systemic
2.3
6.8
55
259
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.6
6.8
39
157
A07AA02
ATC
nystatin; oral
2.7
6.8
37
145
N25.0
ICD-10 Finland
Renal osteodystrophy
40.6
6.8
8
*
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
3.1
6.8
28
94
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
6.7
91
520
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.9
6.7
31
111
XW000
NOMESCO Finland
Bone marrow biopsy
3.0
6.7
29
100
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
22.9
6.7
9
*
J01CF05
ATC
flucloxacillin; systemic
2.6
6.7
39
158
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
6.6
6.7
16
25
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.1
6.6
28
95
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.5
6.6
40
165
C07AB07
ATC
bisoprolol; oral
1.6
6.6
257
1968
Z2221
NOMESCO Finland
Medical doctor
1.7
6.6
139
910
I50.0
ICD-10 Finland
Congestive heart failure
2.3
6.5
50
230
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
6.5
80
442
R31
ICD-10 Finland
Unspecified haematuria
2.1
6.5
61
305
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.4
6.5
18
34
J01DA01
ATC
[U] cefalexin
1.6
6.5
309
2482
E11.09
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - With coma
70.7
6.4
7
*
A10AA02, ,
ATC
3.1
6.4
26
86
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
14.5
6.4
10
7
M05BA01
ATC
etidronic acid; systemic
14.5
6.4
10
7
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
6.4
163
1120
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.9
6.3
18
47
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.8
6.3
31
115
L93.0
ICD-10 Finland
Discoid lupus erythematosus
18.3
6.3
9
5
M81.4
ICD-10 Finland
Drug-induced osteoporosis
18.3
6.3
9
5
M05BX04
ATC
denosumab; parenteral
2.6
6.3
37
151
N085, M319,
ICD-10 Finland
+∞
6.3
6
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
6.3
6
*
99850
ICD-8 Finland
Other complications of surgical procedures, Postoperative wound infection
27.0
6.2
8
*
6BA02, ,
NOMESCO Finland
27.0
6.2
8
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.6
6.2
20
57
N05CF01
ATC
zopiclone; oral
1.6
6.2
169
1180
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
4.1
6.2
17
43
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
6.4
6.2
15
24
I50.1
ICD-10 Finland
Left ventricular failure
2.6
6.2
35
140
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.9
6.1
18
48
E0000UV, ,
ATC
1.6
6.1
199
1451
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
6.1
69
370
C01AA05
ATC
digoxin; systemic
2.3
6.1
49
230
B05DA
ATC
Isotonic solutions
12.7
6.1
10
8
TK810
NOMESCO Finland
Hemofiltration
12.7
6.1
10
8
N19
ICD-10 Finland
Unspecified kidney failure
3.0
6.1
26
89
B03XA01
ATC
erythropoietin; parenteral
8.7
6.1
12
14
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
10.2
6.1
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
129
85
20.01
153.34
5.9
1.1
13.34
—
iu/ml
—
28
0
110
64
21.67
138.29
3.1
1.1
361.43
—
titre
—
14
0
127
110
15.07
129.03
2.4
1.1
1.20
1.20
g/l
0.09
122
105
88
60
17.54
101.42
7.1
1.1
—
—
—
0
0
189
479
5.70
74.32
1.8
1.3
701.64
363.88
titre
1.32
61
103
143
295
6.36
69.99
5.2
2.8
9.24
10.48
g/l
2.39
138
271
86
113
8.96
63.54
1.5
1.1
0.55
2.75
u/ml
—
6
10
117
232
6.26
59.03
2.1
1.7
0.89
1.45
g/l
2.27
111
214
172
504
4.65
54.86
13.6
5.6
1.09
1.03
mmol/l
1.45
163
465
129
312
5.20
51.85
2.0
3.1
64.69
66.53
g/l
1.58
123
286
41
24
18.50
50.21
1.8
1.2
407.50
70.00
titre
—
12
6
358
1859
4.15
49.12
18.0
5.7
—
—
—
0
0
348
1801
3.97
47.30
17.4
5.3
0.61
0.67
%
1.13
341
1680
368
1978
4.14
47.25
16.9
5.1
0.62
0.58
e9/l
2.78
351
1719
368
1984
4.12
46.89
16.9
5.1
0.04
0.04
e9/l
0.13
351
1730
355
1873
3.99
46.61
17.9
5.5
8.54
8.65
%
0.28
348
1759
110
253
5.28
46.57
1.8
3.0
—
—
—
0
0
355
1889
3.93
45.63
16.7
5.2
62.37
57.77
%
10.31
348
1775
373
2051
4.10
45.63
18.0
5.4
0.19
0.19
e9/l
0.05
357
1815
352
1863
3.91
45.61
17.5
5.2
2.52
2.79
%
1.67
345
1745
59
73
9.01
45.34
1.4
1.2
1.94
2.78
u/ml
—
8
8
370
2032
4.04
45.14
17.1
5.2
1.72
1.93
e9/l
1.51
355
1820
59
74
8.89
44.84
1.4
1.1
19.67
3.11
u/ml
0.60
13
11
356
1916
3.88
44.55
17.6
5.4
23.61
27.15
%
8.10
349
1799
169
576
3.90
42.58
5.3
2.4
2.15
2.33
g/l
4.30
164
529
49
52
10.32
42.20
2.0
1.8
0.58
0.81
g/l
0.41
34
43
162
549
3.87
40.97
5.4
2.4
22.57
22.06
%
0.16
146
477
174
634
3.66
39.28
5.2
2.4
11.85
12.76
umol/l
0.87
169
587
251
1150
3.34
39.20
7.4
4.2
—
—
—
0
0
37
30
13.23
37.92
1.4
1.4
6.51
5.98
g/l
0.29
26
24
37
30
13.23
37.92
1.4
1.4
2.60
2.57
g/l
0.02
26
24
37
30
13.23
37.92
1.4
1.4
0.42
0.36
g/l
0.23
26
24
384
2335
3.66
36.25
18.9
8.6
4.82
4.11
e9/l
4.89
370
2041
36
32
12.03
34.82
1.4
1.3
—
—
—
0
0
133
468
3.50
30.88
2.9
1.7
—
—
—
0
0
105
317
3.92
30.63
7.4
3.9
0.85
1.04
%
0.38
53
127
100
293
4.01
30.42
7.7
4.0
0.06
0.17
%
1.20
48
103
121
405
3.61
30.30
2.3
1.5
—
—
—
0
0
59
113
5.78
30.12
2.2
4.4
32.40
30.67
mg/l
0.14
47
92
59
113
5.78
30.12
2.2
4.4
46.52
104.03
mg/l
0.52
45
92
291
1616
2.88
29.89
3.5
2.2
79.17
77.14
nmol/l
0.60
274
1415
97
282
4.02
29.80
7.0
3.9
0.50
0.54
%
0.09
46
105
74
175
4.78
29.74
2.0
1.5
1.71
1.52
g/l
0.67
65
158
337
2035
2.96
29.31
15.8
6.7
1.21
1.21
mmol/l
0.65
280
1727
134
492
3.34
28.89
5.0
2.2
1.87
1.78
%
0.52
123
451
304
1784
2.76
27.14
9.6
4.7
33.11
35.48
g/l
9.45
292
1664
108
364
3.50
26.51
3.4
2.3
69.51
69.05
e9/l
0.05
85
287
171
755
2.91
26.49
2.1
1.4
2.50
2.51
g/l
0.02
138
460
69
169
4.57
26.46
3.1
1.9
1.09
3.31
ug/l
0.68
64
147
46
79
6.30
26.19
2.3
4.7
—
—
—
0
0
90
272
3.81
25.99
8.2
4.1
0.16
0.14
%
0.04
37
85
104
350
3.48
25.52
2.4
1.8
297.25
382.55
nmol/l
4.17
99
316
96
307
3.62
25.48
9.2
3.6
151.66
81.63
ng/l
2.91
90
274
31
35
9.37
25.31
1.3
1.2
—
—
—
0
0
308
1868
2.65
24.94
14.5
5.8
1.20
1.21
mmol/l
1.77
291
1683
52
106
5.35
24.72
2.2
2.0
11.60
12.68
mg/l
0.38
47
100
184
874
2.73
24.49
7.3
2.4
4.22
4.76
e6/l
0.33
177
784
143
595
2.95
24.45
2.3
1.7
—
—
—
0
0
127
505
3.02
23.46
2.3
1.6
—
—
—
0
0
175
839
2.66
22.56
7.4
2.8
509.31
555.21
mosm/kgh2o
2.47
163
710
147
650
2.78
22.18
4.7
3.3
0.82
0.82
mmol/l
0.15
135
610
43
82
5.64
21.94
1.3
1.9
—
—
—
0
0
139
601
2.81
21.86
3.3
2.1
—
—
—
0
0
228
1264
2.46
21.38
8.7
3.1
31.49
117.13
e6/l
0.97
204
972
249
1455
2.40
20.53
10.0
3.6
47.36
122.51
e6/l
1.72
205
1041
64
180
3.92
20.30
1.2
1.3
—
—
—
0
0
79
260
3.41
19.83
1.6
1.4
—
—
—
0
0
36
64
5.98
19.73
5.8
2.3
4.48
4.68
e9/l
0.17
36
64
194
1030
2.43
19.66
4.4
2.6
1974.48
8204.46
umol/l
2.00
181
881
56
147
4.16
19.50
3.2
3.2
0.40
0.24
g/l
0.77
32
53
36
66
5.80
19.11
2.4
1.5
—
—
—
0
0
406
3010
2.75
18.96
13.1
3.7
18.34
12.36
mm/h
8.00
392
2762
36
67
5.71
18.81
6.0
2.7
62.08
58.39
%
0.77
36
67
302
1972
2.31
18.58
7.6
3.7
0.00
0.00
estimate
0.50
79
390
385
2806
2.55
18.21
9.8
4.3
—
—
—
0
0
90
338
3.02
18.07
11.5
8.1
—
—
—
0
0
300
1974
2.27
17.84
10.1
5.0
0.00
0.00
estimate
0.50
75
360
213
1219
2.29
17.78
10.8
3.8
7.40
7.40
ph
0.48
51
218
204
1153
2.29
17.48
8.7
3.0
0.19
0.51
e6/l
3.26
182
865
169
883
2.37
17.38
2.0
1.7
1.50
1.18
mg/l
0.61
137
688
214
1237
2.26
17.34
3.1
2.0
125.67
202.42
u/l
2.96
205
1157
301
2002
2.24
17.18
7.7
3.7
0.00
0.01
estimate
0.50
75
350
198
1116
2.27
16.97
8.4
3.0
—
—
—
0
0
97
398
2.78
16.48
7.8
3.4
1.58
1.92
mmol/l
0.40
88
327
31
57
5.73
16.39
1.5
1.2
2.67
5.38
u/ml
1.02
12
24
28
23
12.81
16.04
2.2
1.8
49.77
37.57
%
2.27
28
23
212
1270
2.15
15.24
3.9
3.1
2204.16
1441.23
ng/l
1.34
189
1081
247
1573
2.11
15.09
6.5
3.5
5.72
5.84
ph
—
9
106
30
58
5.43
15.03
2.0
1.4
123.67
101.44
u/ml
—
8
9
203
1202
2.15
14.99
6.8
3.2
366.31
217.72
mg/l
0.26
151
775
211
1270
2.13
14.91
6.9
3.1
6.79
7.42
mmol/l
1.49
187
1048
261
1703
2.10
14.88
5.5
2.7
177.07
130.70
ug/l
2.99
244
1553
293
2000
2.10
14.75
24.9
14.7
1.34
1.29
inr
0.34
84
570
180
1026
2.17
14.57
3.5
2.1
3.62
3.21
mg/l
0.75
157
872
23
15
15.99
14.53
1.0
1.0
—
—
—
0
0
313
2214
2.08
14.02
6.3
6.1
9.98
11.24
umol/l
2.16
304
2094
106
492
2.46
13.86
7.9
8.0
4.86
5.08
kpa
1.38
100
474
23
37
6.46
13.85
1.0
1.2
—
—
—
0
0
106
493
2.45
13.80
7.9
8.0
11.84
11.94
kpa
0.08
100
477
32
72
4.68
13.50
1.8
1.2
—
—
—
0
0
123
617
2.31
13.47
1.3
1.2
29.79
44.37
iu/ml
1.12
41
191
60
211
3.09
13.37
5.5
3.5
—
—
—
0
0
145
783
2.19
13.26
1.8
1.7
1288.57
1183.82
nmol/l
0.51
123
598
30
65
4.84
13.23
4.4
2.8
—
—
—
0
0
23
39
6.13
13.17
1.3
1.2
—
—
—
0
0
71
277
2.82
13.14
5.9
3.5
7.41
7.40
ph
—
7
27
104
495
2.39
12.79
8.2
8.1
1.11
1.19
mmol/l
0.07
80
397
27
55
5.13
12.77
1.9
3.3
—
—
—
0
0
28
59
4.96
12.75
1.4
1.2
228.20
256.78
u/ml
0.24
20
36
205
1278
2.01
12.69
9.0
3.7
33.35
8.52
mg/mmol
4.11
153
793
260
1763
1.97
12.62
23.1
8.8
0.01
0.00
e9/l
0.45
237
1441
171
1003
2.06
12.50
13.7
6.3
—
—
—
0
0
328
2433
1.99
11.99
8.1
4.8
7.02
6.78
mmol/l
0.77
316
2279
26
60
4.51
10.63
1.3
1.1
—
—
—
0
0
122
665
2.10
10.63
5.8
2.9
3.65
2.18
e6/l
0.81
83
361
17
12
14.61
10.55
1.6
1.2
—
—
—
0
0
22
45
5.07
10.35
3.2
3.7
—
—
—
0
0
348
2701
1.92
10.33
7.9
4.5
123.50
2203.74
e6/l
—
8
43
112
597
2.12
10.32
1.3
1.2
8.42
14.85
u/ml
0.44
43
223
172
1070
1.92
10.27
8.8
3.8
0.00
0.00
estimate
0.50
70
352
34
100
3.57
10.05
1.3
1.2
—
—
—
0
0
196
1280
1.87
10.02
3.7
3.3
—
—
—
0
0
153
922
1.94
10.00
6.6
3.6
—
—
—
0
0
13
5
26.61
9.85
5.7
2.2
—
—
—
0
0
236
1649
1.81
9.57
5.4
3.7
61.57
63.69
ng/l
0.03
178
1179
21
46
4.72
9.14
1.1
1.2
—
—
—
0
0
26
68
3.98
9.07
3.7
3.4
—
—
—
0
0
92
477
2.13
9.03
1.9
1.4
—
—
—
0
0
19
39
5.02
8.90
1.2
2.8
—
—
—
0
0
12
6
20.43
8.50
2.7
1.7
—
—
—
0
0
12
7
17.52
8.11
1.0
1.0
—
—
—
0
0
12
7
17.52
8.11
1.0
1.0
—
—
—
0
0
12
7
17.52
8.11
1.0
1.0
—
—
—
0
0
16
18
9.14
8.09
1.3
1.6
—
—
—
0
0
96
531
2.00
7.86
11.4
6.6
102.96
104.15
mmol/l
1.19
96
531
63
303
2.23
7.41
5.5
5.9
—
—
—
0
0
12
9
13.62
7.41
5.8
5.2
60.63
40.83
%
—
12
9
17
38
4.59
7.23
1.5
1.3
58.09
70.14
%
0.47
11
28
58
274
2.26
7.12
7.2
3.2
115.78
127.28
g/l
3.21
58
268
26
81
3.33
7.07
3.4
2.3
15.49
16.04
%
0.20
12
38
18
43
4.30
7.06
1.2
1.2
—
—
—
0
0
67
337
2.14
7.06
6.9
3.5
—
—
—
0
0
16
23
7.15
7.05
1.2
1.1
—
—
—
0
0
19
35
5.60
6.98
1.1
1.2
—
—
—
0
0
18
44
4.20
6.87
3.3
2.4
1.51
1.68
g/24h
0.12
12
23
27
88
3.18
6.84
6.0
2.8
—
—
—
0
0
48
216
2.35
6.59
7.9
3.6
24.27
25.04
mmol/l
0.83
48
209
27
91
3.08
6.48
1.8
1.6
2963.05
19884.44
e6/l
1.85
20
70
18
35
5.29
6.38
1.6
1.1
—
—
—
0
0
9
5
18.29
6.28
1.1
1.0
—
—
—
0
0
195
1411
1.62
6.22
3.7
3.3
2.31
2.35
mmol/l
3.12
178
1250
16
29
5.66
6.04
1.1
1.2
—
—
—
0
0
223
1678
1.59
5.98
2.3
2.0
94.41
93.75
pmol/l
0.08
122
884
54
267
2.14
5.94
3.7
2.7
4.77
5.45
e9/l
0.27
41
219
28
103
2.82
5.79
1.4
1.2
—
—
—
0
0
17
35
4.99
5.79
1.9
1.1
—
—
—
0
0
16
31
5.29
5.74
2.3
2.4
—
—
—
0
0
53
264
2.13
5.72
2.0
1.6
—
—
—
0
0
63
336
2.00
5.67
3.1
3.3
240.41
229.27
ng/l
0.07
58
302
31
122
2.64
5.65
4.3
2.9
—
—
—
0
0
13
20
6.64
5.59
2.0
1.5
—
—
—
0
0
20
63
3.26
5.37
1.4
1.5
—
—
—
0
0
26
96
2.80
5.35
4.2
2.5
—
—
—
0
0
20
64
3.21
5.24
1.8
1.4
—
—
—
0
0
153
1081
1.59
5.22
8.0
3.3
—
—
—
0
0
38
172
2.31
5.18
9.6
4.4
—
—
—
0
0
45
219
2.16
5.16
7.4
2.4
0.62
0.67
%
0.45
45
219
46
227
2.13
5.10
7.2
2.4
1.19
1.22
%
0.08
46
227
129
880
1.62
5.07
7.8
4.0
1.02
1.02
kg/l
0.39
19
130
15
32
4.80
5.03
1.9
1.1
—
—
—
0
0
179
1321
1.55
5.02
3.9
2.5
—
—
—
0
0
11
16
7.00
4.97
1.1
1.2
—
—
—
0
0
71
412
1.84
4.97
8.7
4.1
—
—
—
0
0
15
33
4.65
4.90
1.2
1.1
—
—
—
0
0
21
73
2.96
4.82
1.5
1.5
—
—
—
0
0
8
7
11.58
4.80
1.0
1.0
—
—
—
0
0
8
7
11.58
4.80
1.0
1.3
—
—
—
0
0
8
7
11.58
4.80
1.0
1.1
—
—
—
0
0
77
466
1.77
4.70
2.7
2.2
184.67
121.27
ug/g
1.18
69
367
7
5
14.17
4.58
1.1
1.2
—
—
—
0
0
175
1307
1.52
4.56
4.3
3.3
38.76
32.69
u/l
0.48
169
1242
25
99
2.60
4.53
1.7
1.2
—
58.00
—
0
5
11
21
5.33
4.16
1.5
1.5
—
—
—
0
0
35
170
2.14
4.07
2.2
1.9
—
—
—
0
0
9
15
6.09
3.83
1.2
1.3
—
—
—
0
0
27
121
2.30
3.81
1.4
1.3
30.55
26.66
iu/l
0.25
21
104
10
20
5.08
3.70
1.4
1.6
—
—
—
0
0
13
35
3.78
3.61
1.0
1.1
—
—
—
0
0
118
847
1.51
3.61
1.7
1.7
424.05
8178341.59
pmol/l
0.50
104
697
441
4068
1.65
3.53
41.6
14.3
25.18
23.67
mg/l
0.47
424
3235
6
6
10.10
3.50
1.3
1.0
9.16
6.13
mg/g
—
6
6
113
810
1.51
3.47
4.6
4.0
435.52
278.24
ng/l
0.28
95
647
72
467
1.63
3.41
1.4
1.3
—
—
—
0
0
135
1007
1.46
3.40
1.9
1.5
18.99
21.14
nmol/l
0.86
124
852
8
14
5.79
3.35
1.1
1.1
—
—
—
0
0
33
171
1.99
3.27
2.2
2.6
—
—
—
0
0
7
11
6.43
3.19
1.4
1.4
—
—
—
0
0
55
341
1.69
3.10
12.5
3.6
—
—
—
0
0
15
56
2.73
3.08
1.2
1.0
—
—
—
0
0
18
74
2.49
3.08
3.3
3.2
0.68
0.78
nmol/l
0.45
12
62
18
74
2.49
3.08
5.0
2.5
—
—
—
0
0
6
8
7.57
3.06
1.3
2.8
—
—
—
0
0
8
16
5.06
3.06
1.1
1.1
—
—
—
0
0
72
480
1.58
3.05
2.9
2.7
9.22
7.48
umol/l
0.34
61
420
61
391
1.64
3.03
2.4
2.5
33.41
31.09
u/l
0.32
56
325
7
12
5.90
3.03
1.0
1.2
—
—
—
0
0
202
1649
1.37
2.99
2.4
2.1
—
—
—
0
0
5
5
10.08
2.98
1.2
1.2
—
—
—
0
0
19
82
2.37
2.95
5.2
1.6
74.96
61.05
%
2.11
19
82
7
13
5.44
2.87
1.0
1.2
—
—
—
0
0
57
366
1.63
2.82
1.6
1.5
—
—
—
0
0
11
33
3.38
2.82
1.0
1.1
—
—
—
0
0
39
226
1.79
2.79
13.9
11.3
—
—
—
0
0
132
1014
1.41
2.79
3.5
2.3
—
—
—
0
0
156
1238
1.38
2.71
5.3
4.0
—
—
—
0
0
7
15
4.72
2.60
1.1
1.3
116.14
163.31
mmol/24h
—
7
15
36
212
1.75
2.47
1.5
1.3
—
—
—
0
0
6
12
5.05
2.41
1.0
1.1
—
—
—
0
0
56
379
1.54
2.25
2.5
2.4
5.23
7.52
ug/l
0.85
46
336
45
290
1.61
2.23
1.2
1.2
—
—
—
0
0
5
9
5.60
2.22
2.0
2.1
—
—
—
0
0
8
24
3.37
2.19
1.9
1.3
—
—
—
0
0
7
19
3.72
2.15
1.3
1.7
9.00
9.31
mmol/l
—
7
19
6
14
4.32
2.15
1.0
1.2
—
—
—
0
0
6
14
4.32
2.15
1.0
1.0
1231.00
1556.86
miu/ml
—
6
14
110
855
1.37
2.13
1.4
1.2
1.55
1.96
u/ml
0.17
32
233
224
1928
1.29
2.12
3.8
2.6
—
—
—
0
0
8
25
3.23
2.10
1.6
1.5
—
—
—
0
0
10
37
2.74
2.08
3.2
1.6
10.67
10.73
%
—
10
37
5
10
5.04
2.07
1.2
1.1
—
—
—
0
0
13
56
2.36
2.06
1.9
1.7
—
—
—
0
0
7
20
3.53
2.06
3.4
1.6
77.21
60.31
ug/l
—
7
20
14
63
2.26
2.02
1.1
1.1
—
—
—
0
0
5
11
4.58
1.94
1.2
1.0
—
—
—
0
0
5
11
4.58
1.94
1.2
1.0
—
—
—
0
0
7
23
3.07
1.80
1.0
1.9
—
—
—
0
0
51
360
1.46
1.72
1.3
1.4
—
—
—
0
0
5
13
3.87
1.72
1.4
1.2
—
—
—
0
0
331
3037
1.26
1.69
4.3
3.8
15.04
14.85
pmol/l
0.67
306
2720
10
40
2.53
1.67
2.6
1.4
—
—
—
0
0
291
2634
1.25
1.66
3.9
3.1
59.93
52.29
u/l
0.83
278
2451
73
555
1.37
1.63
1.3
1.2
—
—
—
0
0
316
2890
1.25
1.63
4.3
3.9
—
—
—
0
0
19
324
0.57
1.63
1.3
1.4
—
—
—
0
0
20
113
1.80
1.63
2.5
2.4
161.80
101.11
ug/min
0.30
15
65
7
26
2.72
1.58
6.0
2.7
—
—
—
0
0
100
806
1.30
1.52
2.7
2.9
2.46
2.45
mmol/l
0.47
89
711
12
58
2.09
1.50
3.7
1.7
30.25
32.78
pg
0.78
12
58
11
52
2.14
1.45
1.3
1.3
0.84
0.54
nmol/l
0.96
11
46
16
88
1.84
1.43
1.3
1.2
14.58
10.63
u/l
—
10
71
6
23
2.63
1.37
1.0
1.0
—
8.88
—
0
6
20
120
1.69
1.36
1.7
1.4
312.40
279.18
ug/g
0.46
15
72
10
47
2.15
1.34
1.3
1.3
—
—
—
0
0
15
83
1.83
1.32
1.9
2.1
4502.04
4194.88
u/l
—
9
30
9
43
2.11
1.31
1.7
1.1
269.11
278.70
mosm/kgh2o
—
9
30
6
24
2.52
1.30
1.0
1.7
91.67
79.38
umol/l
—
6
24
10
48
2.11
1.28
2.2
1.5
—
—
—
0
0
10
48
2.11
1.28
1.3
1.3
—
—
nmol/l
—
0
0
41
297
1.41
1.25
1.6
1.4
—
—
—
0
0
38
272
1.43
1.24
4.6
3.2
—
—
—
0
0
371
3509
1.21
1.14
42.8
17.0
15.49
15.11
%
0.66
371
3464
12
65
1.87
1.14
4.7
2.0
—
—
—
0
0
378
3961
0.82
1.13
5.4
4.6
6.03
6.00
mmol/l
0.11
353
3579
8
40
2.02
1.12
1.3
1.2
—
—
—
0
0
437
4216
1.26
1.04
32.0
13.7
—
—
—
0
0
0
30
0.00
0.97
0.0
1.4
—
1.74
—
0
22
8
145
0.54
0.94
1.8
1.6
—
—
—
0
0
32
427
0.73
0.93
1.5
1.7
—
—
—
0
0
5
101
0.49
0.90
1.2
1.3
—
—
—
0
0
393
3778
1.18
0.82
7.7
5.8
41.20
40.18
mmol/mol
1.21
379
3490
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
8
48
1.68
0.79
1.1
2.2
—
—
—
0
0
121
1360
0.86
0.78
3.4
2.9
—
—
—
0
0
0
27
0.00
0.77
0.0
2.2
—
7.01
—
0
20
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
7
38
1.85
0.74
6.0
2.5
—
—
—
0
0
10
60
1.68
0.72
1.9
1.4
—
—
—
0
0
15
216
0.69
0.70
1.5
1.4
—
—
—
0
0
11
69
1.61
0.69
1.5
1.2
93.47
39.94
u/l
0.41
11
60
5
27
1.86
0.68
1.6
1.2
—
—
—
0
0
38
306
1.26
0.64
1.3
1.4
—
—
—
0
0
11
165
0.66
0.64
1.5
1.7
—
—
—
0
0
5
29
1.73
0.64
1.6
1.2
92.04
181.33
pmol/l
—
5
29
12
79
1.53
0.63
1.2
1.2
—
—
—
0
0
32
253
1.28
0.63
1.6
1.2
79.97
163.04
iu/ml
1.81
17
104
18
244
0.73
0.62
1.5
1.2
—
—
—
0
0
13
88
1.49
0.61
16.1
3.6
36.03
33.65
mg/l
—
7
52
6
35
1.72
0.58
1.0
1.2
279.33
369.30
nmol/l
—
6
30
8
55
1.46
0.56
1.0
1.2
—
—
—
0
0
8
55
1.46
0.56
1.0
1.2
—
—
—
0
0
26
204
1.29
0.55
2.8
2.5
—
—
—
0
0
17
125
1.37
0.54
5.4
5.0
—
—
—
0
0
7
46
1.53
0.48
1.6
2.0
—
—
—
0
0
20
155
1.30
0.47
1.0
1.1
—
—
—
0
0
5
82
0.61
0.46
1.6
1.6
—
—
—
0
0
5
31
1.62
0.43
1.0
1.0
—
—
—
0
0
381
3714
1.10
0.41
5.2
4.6
1.85
2.25
mu/l
0.63
356
3354
14
105
1.34
0.41
4.1
2.6
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
68.50
—
0
12
0
17
0.00
0.40
0.0
1.4
—
1.31
—
0
12
0
18
0.00
0.40
0.0
1.4
—
126.67
—
0
18
5
36
1.39
0.38
1.0
1.3
—
—
—
0
0
9
69
1.31
0.37
5.4
2.7
106.00
105.51
mmol/l
—
9
69
9
69
1.31
0.37
5.4
2.7
4.06
4.08
mmol/l
—
9
69
5
79
0.63
0.35
1.2
1.1
—
—
—
0
0
390
3975
0.92
0.32
5.4
4.4
1.47
1.46
mmol/l
0.14
362
3631
7
55
1.28
0.30
3.3
1.4
—
—
—
0
0
13
104
1.26
0.26
1.0
1.1
—
—
—
0
0
25
217
1.16
0.25
7.1
4.0
—
—
—
0
0
5
40
1.25
0.22
4.0
2.9
—
—
—
0
0
83
789
1.06
0.17
2.6
3.0
0.69
0.78
ug/l
0.47
59
517
8
68
1.18
0.16
6.0
2.7
—
—
—
0
0
396
4003
0.95
0.16
5.4
4.5
4.55
4.61
mmol/l
0.46
366
3682
9
78
1.16
0.15
3.0
1.5
—
—
—
0
0
56
530
1.06
0.13
1.4
1.3
—
—
—
0
0
48
452
1.07
0.13
2.4
4.2
85.62
34.19
ug/l
0.27
39
384
18
200
0.90
0.12
1.3
1.1
—
111.83
—
0
6
12
104
1.16
0.12
2.3
1.4
—
—
—
0
0
406
4089
0.96
0.10
5.7
5.0
2.59
2.72
mmol/l
2.06
384
3732
6
54
1.11
0.09
1.2
1.2
—
—
—
0
0
31
292
1.07
0.09
2.1
2.1
12.70
13.27
nmol/l
0.14
24
263
447
4492
0.96
0.08
53.7
21.3
38.73
40.06
%
4.51
427
4192
381
3832
0.98
0.06
5.0
4.0
1.38
1.27
mmol/l
2.00
356
3473
10
91
1.10
0.04
2.4
1.3
—
—
—
0
0
12
111
1.08
0.04
2.5
1.4
—
—
—
0
0
12
111
1.08
0.04
2.5
1.4
—
—
—
0
0
12
111
1.08
0.04
2.5
1.4
—
—
—
0
0
12
111
1.08
0.04
2.5
1.4
—
—
—
0
0
12
128
0.94
0.02
1.1
1.1
—
—
—
0
0
14
148
0.94
0.02
15.4
9.9
—
—
—
0
0
14
133
1.05
0.01
1.9
1.2
—
—
—
0
0
107
1079
0.99
0.01
1.7
1.6
1.49
1.37
mmol/l
0.59
93
890
141
1403
1.01
0.00
4.0
5.0
2.39
2.63
ug/l
0.21
121
1237
108
1085
0.99
0.00
1.4
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
18.30
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
16.37
—
0
7
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
1.95
—
0
7
0
6
0.00
-0.00
0.0
2.3
—
74.83
—
0
6
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint M13_NECROVASCNAS and mortality.

Females

Parameter HR [95% CI] p-value
M13_NECROVASCNAS 2.738 [2.25, 3.33] < 0.001
Birth year 0.994 [0.99, 1.0] 0.152

During the follow-up period (1.1.1998 — 31.12.2019), 421 out of 1141 females with M13_NECROVASCNAS died.

Males

Parameter HR [95% CI] p-value
M13_NECROVASCNAS 2.719 [2.19, 3.38] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 382 out of 930 males with M13_NECROVASCNAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_NECROVASCNAS.

N-year risk Females Males
1 0.155% 0.461%
5 1.405% 3.089%
10 3.493% 7.542%
15 7.111% 14.245%
20 12.552% 22.975%

Relationships between endpoints

↥

Index endpoint: M13_NECROVASCNAS – Other specified/unspecified necrotizing vasculopathies

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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