spinal stenosis: Narrowing of the spinal canal.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
291 |
4. Check minimum number of eventsNone |
291 |
5. Include endpointsNone |
291 |
6. Filter based on genotype QC (FinnGen only) |
286 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M48
- Name in latin
- Vertebra collapsa non alibi classificata
Similar endpoints
↥List of similar endpoints to
Collapsed vertebra, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2977 | 1951 | 1011 |
| Only index persons | 2606 | 1732 | 874 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 76.32 | 78.64 | 71.80 |
| Only index persons | 76.04 | 78.45 | 71.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 286 | 185 | 101 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | 73.26 | 74.19 | 71.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 291
- Matched controls
- 2910
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M48.5
ICD-10 Finland
Collapsed vertebra, not elsewhere classified
+∞
307.7
291
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
23.1
115.7
94
59
M48.0
ICD-10 Finland
Spinal stenosis
39.7
87.2
55
17
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
9.3
76.9
128
227
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
31.4
76.8
52
20
M54.5
ICD-10 Finland
Low back pain
8.2
73.3
154
349
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
30.8
72.1
49
19
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
18.6
71.2
61
41
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
21.6
62.6
49
27
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
28.7
60.6
42
17
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
12.4
60.1
66
67
M54.9
ICD-10 Finland
Dorsalgia, unspecified
11.7
57.7
66
71
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
19.3
55.9
46
28
N03AX16
ATC
[U] pregabalin
6.7
51.3
109
239
N02AX02
ATC
tramadol; systemic, rectal
4.9
39.9
176
693
N02AA05
ATC
oxycodone; systemic
4.8
36.8
118
359
L03
ICPC
Low back symptom/complaint
4.6
32.5
107
328
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
10.7
32.2
37
39
N03AX12
ATC
[U] gabapentin; oral
5.8
32.1
69
148
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.3
31.8
190
890
M81.9
ICD-10 Finland
Osteoporosis, unspecified
6.9
30.3
52
89
M54.6
ICD-10 Finland
Pain in thoracic spine
10.3
29.8
35
38
M05BX04
ATC
denosumab; parenteral
6.1
27.4
53
102
M05BA04
ATC
alendronic acid; oral
4.5
26.2
79
223
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.6
26.1
165
771
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
6.3
25.2
47
87
M54.4
ICD-10 Finland
Lumbago with sciatica
5.6
25.0
53
111
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
90.9
23.0
25
*
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
130.3
22.9
24
*
L95
ICPC
Osteoporosis
7.0
22.9
37
59
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
56.8
22.5
26
5
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
6.1
21.9
41
76
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
40.5
21.2
26
7
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
23.6
18.5
26
12
X59
ICD-10 Finland
Exposure to unspecified factor
3.5
17.7
76
269
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.1
17.6
101
426
N02BF02
ATC
pregabalin; oral
7.2
17.3
27
41
C03CA01
ATC
furosemide; systemic
2.9
17.3
166
921
318
Kela drug reimbursment
Teriparatide
53.4
17.2
20
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.9
17.2
121
570
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
4.9
17.0
41
95
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
16.4
127
626
M54
ICD-10 Finland
Dorsalgia
4.7
16.4
41
98
N06AX21
ATC
duloxetine; oral
4.8
16.0
39
91
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
16.0
175
1025
N02BF01
ATC
gabapentin; oral
5.6
15.9
32
63
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.3
15.7
73
270
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
15.5
119
580
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.0
15.0
48
138
M01AH02
ATC
rofecoxib; oral
3.5
15.0
61
207
M03BX02
ATC
tizanidine; oral
2.7
14.9
163
943
H05AA02
ATC
teriparatide; parenteral
38.2
14.6
18
5
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.6
14.4
138
747
Z01.8
ICD-10 Finland
Other specified special examinations
2.9
13.8
80
334
L28
ICPC
Limited function/disability (L)
2.8
13.2
84
367
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.4
13.2
54
183
A06AD11
ATC
lactulose; oral
2.8
12.9
81
351
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.4
12.5
50
167
C07AB07
ATC
bisoprolol; oral
2.5
12.3
193
1280
A02BC01
ATC
omeprazole; systemic
2.5
12.3
107
545
A02BC02
ATC
pantoprazole; systemic
2.7
12.1
217
1525
R07.4
ICD-10 Finland
Chest pain, unspecified
2.5
12.1
102
511
AA1AD
NOMESCO Finland
CT of head and brain
2.5
12.0
112
588
R53
ICD-10 Finland
Malaise and fatigue
2.5
11.7
97
481
L02
ICPC
Back symptom/complaint
3.8
11.6
38
111
C90.0
ICD-10 Finland
Multiple myeloma
12.5
11.5
20
17
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
124.7
11.5
12
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
11.4
116
630
S22.3
ICD-10 Finland
Fracture of rib
4.1
11.4
33
88
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.7
11.3
73
319
JN3AD
NOMESCO Finland
Abdominal CT examination
3.2
11.3
49
172
L86
ICPC
Back syndrome with radiating pain
5.6
11.2
22
42
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
11.0
71
310
R52.9
ICD-10 Finland
Pain, unspecified
3.7
11.0
38
115
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
16.3
11.0
17
11
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.4
10.9
115
631
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
13.6
10.8
18
14
NA1AD
NOMESCO Finland
Cervical spine CT examination
5.3
10.7
22
44
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.2
10.7
30
78
N06AX11
ATC
mirtazapine; oral
2.3
10.5
115
640
ZXD05
NOMESCO Finland
Urgent procedure
2.3
10.2
103
552
N02BE01
ATC
paracetamol; systemic, rectal
3.8
10.2
267
2164
A02BC05
ATC
esomeprazole; systemic
2.2
10.0
126
741
N03AE01
ATC
clonazepam; systemic
4.8
10.0
23
51
M54.8
ICD-10 Finland
Other dorsalgia
11.2
9.9
18
17
M43.1
ICD-10 Finland
Spondylolisthesis
20.9
9.9
14
7
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.7
9.8
61
260
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.8
9.8
56
229
B01AB05
ATC
enoxaparin; parenteral
2.2
9.8
114
648
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.7
9.7
23
52
X58
ICD-10 Finland
Exposure to other specified factors
3.0
9.6
47
176
153
Kela drug reimbursment
Lenalidomid
18.3
9.5
14
8
N04BC05
ATC
pramipexole; oral
3.4
9.3
36
117
Z3231
NOMESCO Finland
Registered nurse
2.3
9.3
95
510
R50.9
ICD-10 Finland
Fever, unspecified
2.7
9.2
55
230
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.3
9.1
37
124
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.0
9.1
43
158
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
38.0
9.1
11
*
UJF32
NOMESCO Finland
Coloscopy
2.3
9.0
92
492
A07AA02
ATC
nystatin; oral
3.6
8.9
30
89
H02AB06
ATC
prednisolone; systemic
2.1
8.9
151
986
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.5
8.8
22
52
329
Kela drug reimbursment
Lenalidomide
51.6
8.7
10
*
M51.8
ICD-10 Finland
Other specified intervertebral disc disorders
51.6
8.7
10
*
L04AX04
ATC
lenalidomide; oral
16.9
8.6
13
8
N06AX16
ATC
venlafaxine; oral
3.0
8.5
40
146
SPAT1229
SPAT
Assessment of need for aid
3.1
8.5
37
129
NF1AA
NOMESCO Finland
Hip X-ray examination
3.0
8.5
41
152
N30.0
ICD-10 Finland
Acute cystitis
2.5
8.5
63
292
D07AC01
ATC
betamethasone; topical
2.1
8.5
113
670
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
9.0
8.4
17
20
B01AF02
ATC
apixaban; oral
2.5
8.4
60
273
R52.2
ICD-10 Finland
Other chronic pain
7.4
8.4
19
27
R4110
NOMESCO Finland
Physiotherapy
2.2
8.4
92
505
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
8.4
8
*
M03BC01
ATC
orphenadrine (citrate); systemic
2.6
8.3
53
228
A02BC03
ATC
lansoprazole; oral
2.2
8.3
99
562
A02BA02
ATC
ranitidine; systemic
2.3
8.2
80
418
M01AH05
ATC
etoricoxib; oral
2.0
8.2
154
1033
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
17.8
8.1
12
7
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
17.8
8.1
12
7
K59.09
ICD-10 Finland
Constipation, unspecified
3.5
8.0
28
85
R5110, ,
SPAT
3.3
8.0
31
101
N05BA04
ATC
oxazepam; oral
2.2
7.9
88
484
SPAT1255
SPAT
Intravenous administration of medicine
3.4
7.9
29
91
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
7.8
53
235
Z02.7
ICD-10 Finland
Issue of medical certificate
3.5
7.7
28
87
Z2446
NOMESCO Finland
Social worker
3.5
7.7
28
87
M05BA07
ATC
risedronic acid; oral
3.8
7.6
24
68
M79.6
ICD-10 Finland
Pain in limb
2.0
7.5
114
702
M47.9
ICD-10 Finland
Spondylosis, unspecified
82.1
7.5
8
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.3
7.4
65
323
A97
ICPC
No disease
2.3
7.4
64
316
WW402
NOMESCO Finland
Leucoferesis
+∞
7.3
7
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
7.3
49
216
A28
ICPC
Limited function/disability NOS
2.1
7.3
82
452
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
7.2
102
611
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.2
7.2
30
102
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
30.8
7.2
9
*
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
30.8
7.2
9
*
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
30.8
7.2
9
*
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
7.2
50
224
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.8
7.2
22
61
J01DB01
ATC
cefalexin; oral
2.2
7.2
231
1844
Z3226
NOMESCO Finland
Physiotherapist
2.3
7.1
61
300
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
7.1
32
114
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
7.1
60
294
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
7.0
69
359
A06AC01
ATC
ispaghula (psylla seeds); oral
2.0
6.9
91
530
ZXA05
NOMESCO Finland
Left side
2.1
6.9
88
507
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.2
6.9
73
392
M47.82
ICD-10 Finland
Other spondylosis, cervical region
11.3
6.9
12
11
SCA01
NOMESCO Finland
Preventive oral health care, short
2.2
6.8
71
379
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.2
6.7
18
45
B01AA03
ATC
warfarin; systemic
2.0
6.7
89
519
N06AB03
ATC
fluoxetine; oral
2.7
6.7
38
154
N30.9
ICD-10 Finland
Cystitis, unspecified
3.0
6.6
30
107
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.0
6.6
92
546
A04AA01
ATC
ondansetron; systemic, rectal
2.9
6.6
32
119
ZX120
NOMESCO Finland
Intravenous
2.7
6.6
36
143
SPAT1260
SPAT
Consultation of another employee
2.2
6.6
61
310
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
6.6
91
539
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
4.1
6.5
18
46
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
6.5
61
311
UKC02
NOMESCO Finland
Cystoscopy
2.3
6.5
53
255
WX892
NOMESCO Finland
Monitored bed care
3.0
6.5
29
103
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
71.4
6.5
7
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
71.4
6.5
7
*
W19
ICD-10 Finland
Unspecified fall
2.5
6.4
41
176
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.6
6.4
21
61
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
6.4
119
778
207
Kela drug reimbursment
Chronic arrhythmias
2.1
6.3
73
404
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.8
6.3
19
52
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
18.5
6.3
9
5
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
6.3
6
*
J05AB11
ATC
valaciclovir; oral
2.4
6.3
46
211
WW300
NOMESCO Finland
Transfer of autologic stem cells
27.3
6.3
8
*
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
6.0
6.2
16
28
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.8
6.2
31
117
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
6.2
39
166
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.2
6.2
58
295
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.5
6.2
42
186
N06AB05
ATC
paroxetine; oral
3.8
6.1
19
53
R33
ICD-10 Finland
Retention of urine
2.8
6.1
32
124
S42.2
ICD-10 Finland
Fracture of upper end of humerus
3.0
6.1
28
101
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.0
6.1
28
101
J96.1
ICD-10 Finland
Chronic respiratory failure
6.3
6.1
15
25
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.8
6.0
30
113
J01EA01
ATC
trimethoprim; systemic
1.9
6.0
101
635
XW000
NOMESCO Finland
Bone marrow biopsy
3.3
6.0
23
74
N02AC04
ATC
dextropropoxyphene; oral
3.8
6.0
18
49
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
39
73
6.01
20.57
14.7
3.6
57.33
71.00
mg/l
0.10
31
56
39
73
6.01
20.57
14.4
3.6
77.59
89.25
mg/l
0.11
31
56
133
625
3.08
19.43
5.0
3.0
0.37
0.51
e6/l
0.48
107
482
199
1173
3.20
19.31
13.9
5.9
1.20
1.22
mmol/l
1.63
167
966
91
355
3.27
18.13
3.6
2.2
11.61
12.06
umol/l
0.20
84
317
84
313
3.37
18.03
3.5
2.2
20.70
21.18
%
0.11
75
258
87
334
3.29
17.76
3.4
2.2
2.20
2.29
g/l
0.80
81
297
164
898
2.89
17.64
3.1
2.2
79.52
78.36
nmol/l
0.20
150
759
155
824
2.89
17.63
5.6
3.0
—
—
—
0
0
123
593
2.86
16.61
2.8
2.2
3.30
3.29
mg/l
0.01
98
492
173
1010
2.76
15.89
7.0
4.0
33.45
34.70
g/l
1.90
153
910
185
1124
2.77
15.59
9.5
5.9
11.04
12.35
umol/l
0.97
171
1056
91
385
2.98
15.48
2.5
1.8
—
—
—
0
0
50
146
3.93
15.35
6.0
3.0
10.83
10.55
g/l
0.09
43
132
136
714
2.70
15.28
5.6
3.1
28.62
143.49
e6/l
0.70
107
559
176
1060
2.67
14.81
6.3
4.1
0.00
0.00
estimate
-0.00
34
214
83
347
2.95
14.30
5.2
2.8
4.56
2.98
e6/l
0.39
44
194
147
824
2.58
14.17
3.9
3.2
2223.47
1967.25
ng/l
0.18
125
695
174
1060
2.60
14.02
14.6
5.2
1.20
1.21
mmol/l
1.77
163
932
70
273
3.06
13.58
2.2
1.8
—
—
—
0
0
147
837
2.53
13.53
4.3
2.6
136.78
132.86
ug/l
0.09
130
740
143
804
2.53
13.52
4.2
3.1
2.32
2.36
mmol/l
2.81
131
687
122
638
2.57
13.44
3.3
2.3
50.50
57.77
u/l
1.76
107
580
173
1072
2.51
13.13
9.1
5.7
0.00
0.00
estimate
-0.00
30
187
163
986
2.48
13.00
11.8
5.3
61.02
58.57
%
1.75
152
927
82
357
2.81
12.98
4.2
2.7
1.04
1.44
e6/l
0.57
44
202
69
275
2.98
12.83
2.2
1.7
—
—
—
0
0
172
1072
2.48
12.76
6.4
4.1
0.00
0.00
estimate
-0.00
31
185
183
1177
2.49
12.61
29.8
17.1
1.29
1.37
inr
0.55
46
351
162
996
2.41
12.20
12.2
5.6
23.07
26.21
%
3.37
152
931
231
1673
2.85
12.19
14.8
6.9
84.88
80.95
u/l
0.51
218
1529
184
1207
2.43
11.83
17.8
8.6
4.50
4.21
e9/l
0.81
160
1055
58
222
3.01
11.51
5.2
1.9
7.18
10.80
umol/l
1.11
48
190
36
104
3.81
11.12
1.9
1.8
0.28
4.43
ug/l
0.84
28
88
81
378
2.58
10.99
1.3
1.2
1.57
1.02
u/ml
0.34
20
85
36
107
3.70
10.67
12.6
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
30
79
4.12
10.51
4.5
2.1
0.36
0.35
u/ml
0.05
19
48
63
267
2.74
10.30
10.8
5.9
1.62
1.52
mmol/l
0.05
56
218
215
1568
2.42
10.06
6.5
3.9
19.49
15.17
mm/h
1.99
198
1396
48
179
3.01
9.91
2.2
1.5
—
—
—
0
0
148
938
2.18
9.62
6.3
3.8
47.89
80.68
ng/l
0.43
120
713
49
189
2.92
9.51
2.6
2.0
33.68
29.22
u/l
0.53
41
157
44
162
3.02
9.27
1.9
1.6
—
—
—
0
0
153
999
2.12
9.03
2.5
2.1
91.56
95.12
pmol/l
0.34
83
474
187
1324
2.15
8.84
10.6
4.3
6.91
6.80
mmol/l
0.19
178
1229
46
180
2.85
8.68
2.2
2.0
330.85
402.21
nmol/l
1.01
40
159
115
696
2.08
8.08
2.9
1.9
240.56
313.92
u/l
0.20
104
645
95
535
2.15
8.07
2.3
1.8
1127.46
1087.75
nmol/l
0.15
70
391
103
601
2.10
7.96
2.0
1.5
19.57
21.31
nmol/l
0.56
89
480
106
627
2.09
7.89
4.4
2.8
34.43
33.83
u/l
0.04
95
599
26
76
3.66
7.87
16.0
1.9
0.00
0.00
g/l
-0.00
26
66
33
113
3.17
7.83
2.9
3.7
1.62
2.44
mmol/l
0.45
24
91
26
77
3.61
7.72
16.0
1.9
0.00
0.00
g/l
-0.00
26
66
21
55
4.04
7.39
1.7
1.4
—
—
—
0
0
85
474
2.12
7.31
4.5
2.9
2.47
2.47
mmol/l
0.10
79
416
45
190
2.62
7.31
4.0
3.1
79.43
81.69
ng/l
0.07
35
158
142
962
1.93
6.99
3.8
2.4
—
—
—
0
0
144
982
1.92
6.93
2.5
2.5
—
—
—
0
0
170
1227
1.93
6.86
4.5
2.8
71.08
53.93
u/l
1.28
153
1105
22
63
3.70
6.86
1.4
1.8
—
—
—
0
0
83
470
2.07
6.80
5.9
3.5
158.38
321.93
ng/l
0.75
73
397
17
42
4.24
6.45
1.8
1.9
—
—
—
0
0
48
224
2.37
6.29
6.5
3.1
3.25
2.18
mmol/l
1.30
43
182
33
130
2.74
6.12
2.4
1.7
1.84
1.52
%
0.42
26
111
250
2105
2.33
6.10
40.1
15.1
25.61
25.54
mg/l
0.01
230
1713
35
143
2.65
6.05
2.2
1.4
—
—
—
0
0
16
41
4.07
5.79
1.4
1.2
—
—
—
0
0
86
519
1.93
5.78
3.7
2.3
—
—
—
0
0
17
48
3.70
5.41
1.3
1.4
—
—
—
0
0
17
48
3.70
5.41
1.3
1.4
—
—
—
0
0
75
441
1.94
5.40
2.4
1.7
1.62
1.46
mg/l
0.15
64
350
58
311
2.08
5.40
1.3
1.2
24.67
38.72
iu/ml
0.83
23
106
18
53
3.55
5.40
1.8
1.8
—
—
—
0
0
18
54
3.49
5.25
1.9
1.8
—
—
—
0
0
45
222
2.21
5.16
2.3
2.3
5.46
6.33
ug/l
0.18
35
187
12
19
6.54
5.13
2.6
3.1
—
—
—
0
0
14
29
5.02
4.87
1.6
1.7
—
—
—
0
0
18
57
3.30
4.85
1.8
1.3
—
—
—
0
0
52
279
2.05
4.81
1.2
1.2
42.54
15.56
u/ml
0.47
14
99
14
31
4.69
4.62
1.5
1.7
—
—
—
0
0
22
82
2.82
4.53
3.6
3.3
0.76
0.79
nmol/l
0.10
16
65
119
843
1.70
4.50
7.5
4.4
—
—
—
0
0
15
37
4.22
4.47
1.6
1.6
—
—
—
0
0
14
34
4.27
4.27
1.6
1.6
—
—
—
0
0
21
80
2.75
4.16
3.3
3.2
—
—
—
0
0
20
76
2.75
3.99
1.9
1.2
—
—
—
0
0
11
23
4.93
3.91
1.5
1.7
—
—
—
0
0
12
28
4.42
3.86
1.5
1.8
—
—
—
0
0
10
19
5.41
3.86
1.9
1.6
—
—
—
0
0
6
5
12.21
3.78
1.2
1.0
—
—
—
0
0
74
483
1.71
3.68
6.9
4.4
1.01
1.02
kg/l
0.87
21
82
79
531
1.67
3.51
4.7
2.9
7035.16
8629.04
umol/l
0.08
68
458
13
42
3.19
3.41
3.2
2.2
15.36
15.86
%
—
5
22
7
10
7.14
3.38
2.3
1.2
—
—
—
0
0
8
14
5.84
3.36
1.4
1.3
—
—
—
0
0
7
11
6.49
3.20
1.7
1.8
—
—
—
0
0
251
2255
1.82
3.14
20.3
10.1
22.18
23.65
u/l
0.95
238
2141
79
545
1.62
3.14
1.8
1.8
416.05
23529848.03
pmol/l
0.78
61
425
10
25
4.10
3.11
1.3
1.7
—
—
—
0
0
251
2260
1.80
3.05
44.6
18.1
138.69
139.55
mmol/l
4.22
241
2182
7
12
5.95
3.04
1.7
1.8
—
—
—
0
0
251
2261
1.80
3.03
45.8
18.2
3.97
3.99
mmol/l
0.30
241
2181
5
5
10.14
2.99
1.0
1.4
—
—
—
0
0
12
38
3.25
2.88
1.8
1.7
—
—
—
0
0
12
38
3.25
2.88
1.8
1.7
—
—
—
0
0
16
66
2.51
2.76
1.5
1.2
—
—
—
0
0
7
14
5.09
2.74
1.7
1.6
—
—
—
0
0
16
67
2.47
2.68
1.5
1.2
—
—
—
0
0
12
41
3.01
2.65
1.3
1.5
—
—
—
0
0
42
256
1.75
2.64
5.9
3.2
—
—
—
0
0
7
15
4.75
2.61
3.3
1.7
368.14
375.13
e6/l
—
7
15
188
1608
1.48
2.57
5.1
3.9
15.53
15.18
pmol/l
0.94
175
1387
226
2012
1.55
2.51
34.7
15.0
73.13
72.67
ml/min/173m2
0.11
196
1639
9
26
3.54
2.50
1.9
2.0
—
—
—
0
0
37
222
1.76
2.46
3.2
1.8
0.21
0.20
g/l
0.29
31
207
14
58
2.49
2.41
1.6
1.4
246.22
289.66
ug/g
—
9
36
5
8
6.33
2.38
1.0
1.0
—
—
—
0
0
5
8
6.33
2.38
4.6
3.4
—
—
—
0
0
254
2335
1.69
2.34
54.9
22.4
37.34
38.97
%
2.68
231
2141
9
28
3.28
2.32
1.6
1.5
—
—
—
0
0
9
28
3.28
2.32
3.1
3.4
59.78
57.29
%
—
9
28
254
2336
1.69
2.32
54.7
22.5
126.00
131.75
g/l
6.94
247
2281
254
2336
1.69
2.32
54.1
22.4
4.18
4.38
e12/l
6.55
243
2242
6
13
4.69
2.28
1.2
1.9
—
—
—
0
0
6
13
4.69
2.28
1.2
1.9
—
—
—
0
0
5
9
5.63
2.22
1.4
1.4
1.33
1.03
g/l
—
5
9
5
9
5.63
2.22
2.6
1.3
197.00
214.78
u/l
—
5
9
8
24
3.40
2.19
1.3
1.5
—
—
—
0
0
8
24
3.40
2.19
1.3
1.5
—
—
—
0
0
6
14
4.35
2.16
3.5
1.4
—
—
—
0
0
253
2335
1.64
2.15
53.8
22.4
244.22
243.61
e9/l
0.04
242
2253
8
25
3.26
2.11
1.9
2.0
—
—
—
0
0
26
147
1.84
2.10
2.0
3.2
55.00
54.73
ml/min/173m2
—
10
71
10
37
2.76
2.09
1.3
1.4
—
—
—
0
0
6
15
4.06
2.05
2.0
2.0
—
—
—
0
0
8
26
3.13
2.03
1.4
1.2
—
—
—
0
0
35
219
1.68
2.02
1.5
1.4
—
—
—
0
0
8
27
3.02
1.95
4.1
4.1
—
—
—
0
0
8
27
3.02
1.95
1.8
1.4
3.27
142.72
u/ml
—
8
27
8
27
3.02
1.95
1.1
1.1
—
—
—
0
0
5
12
4.22
1.83
1.4
1.0
—
—
—
0
0
222
2015
1.43
1.82
7.1
6.1
42.03
40.82
mmol/mol
0.73
203
1810
217
1971
1.40
1.70
6.1
4.8
1.91
2.06
mu/l
0.92
203
1711
77
596
1.40
1.68
7.2
4.1
0.00
0.00
estimate
-0.00
30
185
231
2124
1.42
1.65
5.0
5.1
2.44
2.60
mmol/l
1.99
204
1882
17
91
1.92
1.64
1.5
1.3
—
—
—
0
0
12
57
2.15
1.57
1.2
1.3
—
—
—
0
0
7
27
2.63
1.52
2.6
1.3
—
—
—
0
0
7
27
2.63
1.52
2.6
1.3
—
—
—
0
0
7
27
2.63
1.52
2.6
1.3
—
—
—
0
0
7
27
2.63
1.52
2.6
1.3
—
—
—
0
0
222
2039
1.37
1.51
4.4
4.5
1.47
1.50
mmol/l
0.39
194
1794
224
2061
1.38
1.50
4.5
4.5
4.34
4.54
mmol/l
1.96
198
1833
17
95
1.84
1.46
3.1
1.9
—
—
—
0
0
7
28
2.54
1.46
2.6
1.3
—
—
—
0
0
215
1972
1.35
1.42
4.1
4.0
1.31
1.26
mmol/l
0.27
180
1714
6
23
2.64
1.37
2.2
2.0
—
—
—
0
0
6
23
2.64
1.37
2.2
2.0
—
—
—
0
0
6
23
2.64
1.37
2.2
2.0
—
—
—
0
0
71
564
1.34
1.31
5.4
5.0
3.90
2.52
ug/l
0.71
60
496
44
323
1.43
1.30
3.1
3.0
0.78
0.84
ug/l
0.21
31
229
15
86
1.78
1.21
2.5
1.6
—
—
—
0
0
8
40
2.03
1.13
1.8
1.3
—
—
—
0
0
5
21
2.40
1.09
1.2
1.8
—
—
—
0
0
11
59
1.90
1.09
1.6
1.3
—
—
—
0
0
9
47
1.94
1.03
1.0
1.2
—
—
—
0
0
56
451
1.30
0.95
4.2
4.2
21.77
21.86
%
0.01
28
226
6
27
2.25
0.94
1.3
1.1
—
—
—
0
0
6
27
2.25
0.94
2.8
1.3
—
—
—
0
0
38
291
1.35
0.91
16.7
7.6
—
—
—
0
0
222
2093
1.26
0.89
5.2
4.8
6.07
6.07
mmol/l
0.00
200
1833
8
47
1.72
0.81
2.5
1.3
—
—
—
0
0
13
83
1.59
0.76
1.1
1.1
—
—
—
0
0
5
27
1.87
0.68
3.2
1.8
—
—
—
0
0
7
44
1.61
0.65
1.3
1.1
—
—
—
0
0
8
53
1.52
0.59
1.1
1.1
—
14.18
—
0
6
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
12
89
1.36
0.38
2.1
1.3
129.26
300.80
u/ml
0.83
12
77
68
743
0.89
0.34
3.9
3.6
8.51
8.25
mg/mmol
0.02
46
457
6
47
1.28
0.32
1.7
1.1
—
—
—
0
0
26
301
0.85
0.29
4.4
4.6
34.00
32.98
%
0.21
18
175
8
64
1.26
0.27
1.9
1.8
—
—
—
0
0
26
225
1.17
0.27
1.3
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
453.80
—
0
5
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
0.98
—
0
6
53
562
0.93
0.15
1.6
1.6
1.42
1.34
mmol/l
0.29
45
438
5
48
1.04
0.09
1.4
2.1
—
—
—
0
0
8
75
1.07
0.07
1.9
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
77.67
—
0
9
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
28.11
—
0
9
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
1383.00
—
0
6
7
75
0.93
-0.00
3.0
3.9
35.43
24.70
mg/l
—
7
47
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
53
0.94
-0.00
1.4
1.3
—
—
—
0
0
6
59
1.02
-0.00
2.3
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_VERTEBCOLLAPSE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VERTEBCOLLAPSE | 1.885 [1.61, 2.21] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.355 |
During the follow-up period (1.1.1998 — 31.12.2019), 934 out of 1714 females with M13_VERTEBCOLLAPSE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VERTEBCOLLAPSE | 2.57 [1.93, 3.42] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 507 out of 886 males with M13_VERTEBCOLLAPSE died.
Mortality risk
Mortality risk for people of age
years, who have M13_VERTEBCOLLAPSE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.216% | 0.475% |
| 5 | 1.281% | 3.061% |
| 10 | 3.045% | 7.447% |
| 15 | 5.762% | 13.539% |
| 20 | 9.692% | 22.336% |
Relationships between endpoints
↥Index endpoint: M13_VERTEBCOLLAPSE – Collapsed vertebra, not elsewhere classified
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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