No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
504 |
4. Check minimum number of eventsNone |
504 |
5. Include endpointsNone |
504 |
6. Filter based on genotype QC (FinnGen only) |
504 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Conotruncal defects
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5696 | 2805 | 2877 |
| Only index persons | 3689 | 1836 | 1853 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 0.60 | 0.54 | 0.45 |
| Only index persons | 2.47 | 3.18 | 1.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 504 | 243 | 261 |
| Unadjusted period prevalence (%) | 0.10 | 0.08 | 0.12 |
| Median age at first event (years) | 6.54 | 10.05 | 3.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 464
- Matched controls
- 4642
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
180.1
161
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
20.9
146.7
240
225
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
139.7
127
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
40.0
135.0
172
67
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
24.8
121.4
179
114
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
12.0
114.9
254
422
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
113.2
104
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
42.4
112.8
141
47
XF404
NOMESCO Finland
Ambulatory ECG
18.0
110.4
185
164
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
84.4
109.1
120
19
XF402
NOMESCO Finland
ECG with work load test
20.6
101.6
159
114
XF400
NOMESCO Finland
ECG with 12 standard connections
8.1
83.2
234
516
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
27.8
74.2
103
47
C03CA01
ATC
furosemide; systemic
10.0
74.2
166
244
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.2
72.9
294
1005
C01AA05
ATC
digoxin; systemic
33.3
71.3
94
35
C03DA01
ATC
spironolactone; oral
16.1
71.3
121
99
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.6
68.3
145
190
B01AA03
ATC
warfarin; systemic
11.9
67.1
132
149
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
150.3
62.6
65
5
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
+∞
61.8
58
*
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
44.3
61.0
75
20
TPH07
NOMESCO Finland
Cathetrisation of artery
8.7
60.4
145
230
31
HP
Congenital heart failure surgery
105.6
59.5
64
7
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
56.4
53
*
FM2CE
NOMESCO Finland
NA
10.1
55.9
120
155
74629
ICD-8 Finland
Congenital anomalies of heart, Tetralogy of Fallot
+∞
54.2
51
*
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
54.2
51
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.4
52.5
160
350
62
HP
Catheterization and pressure measurement of the right side of the heart
285.0
51.1
51
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
34.7
50.9
66
22
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
68.9
48.4
55
9
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
39.4
46.9
59
17
61
HP
Catheterization and pressure measurement of the left side of the heart
60.7
46.6
54
10
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
20.4
46.2
70
40
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
22.1
45.5
67
35
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
30.2
45.5
61
23
WX408
NOMESCO Finland
General anesthesy, balanced
4.1
43.1
236
927
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
51.8
42.9
51
11
Q21.10
ICD-10 Finland
Persistent ostium secundum
14.4
42.1
73
59
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
7.8
38.7
95
147
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
78.4
38.6
43
6
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
36.9
35
*
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
+∞
35.9
34
*
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
+∞
35.9
34
*
7452A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[TETRALOGIA FALLOT]
+∞
34.8
33
*
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
+∞
34.8
33
*
FJF10
NOMESCO Finland
Replacement of pulmonary valve using biological prosthesis
+∞
34.8
33
*
WX872
NOMESCO Finland
Intensive care
17.1
34.4
55
36
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
27.3
34.3
47
19
Z98.8
ICD-10 Finland
Other specified postsurgical states
20.9
33.0
49
26
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
6.7
32.9
90
161
7460C
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITA CUM STENOSIS]
+∞
32.7
31
*
XF620
NOMESCO Finland
Examination of circulation with color method
+∞
32.7
31
*
Q21.3
ICD-10 Finland
Tetralogy of Fallot
+∞
32.7
31
*
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
345.5
32.2
32
*
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
91.4
31.1
34
*
TFP20
NOMESCO Finland
Cardiodefibrillation
14.4
31.0
53
41
XF600
NOMESCO Finland
Bloodpressure measurement
4.9
30.7
113
287
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
88.5
30.1
33
*
R4110
NOMESCO Finland
Physiotherapy
3.4
30.1
191
786
C01BD01
ATC
amiodarone; systemic
39.9
29.7
37
10
7451A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[TRANSPOSITIO CORDIS COMPLETA]
+∞
29.5
28
*
WX882
NOMESCO Finland
High dependency care
5.1
29.0
101
241
I48
ICD-10 Finland
Atrial fibrillation and flutter
6.8
28.9
77
132
74619
ICD-8 Finland
Congenital anomalies of heart, Transposition of great vessels
+∞
28.4
27
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.3
28.2
185
771
207
Kela drug reimbursment
Chronic arrhythmias
8.4
27.7
63
85
Q21.32
ICD-10 Finland
Pulmonary atresia with Fallot ventricular septal defect
+∞
27.3
26
*
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
+∞
26.3
25
*
Q20.48
ICD-10 Finland
Single ventricle
76.8
26.1
29
*
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
76.8
26.1
29
*
XF622
NOMESCO Finland
Measurement of minute volume of heart
32.1
25.3
33
11
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
25.2
24
*
Q21.31
ICD-10 Finland
Tetralogy of Fallot and double outlet right ventricle
+∞
25.2
24
*
I37.2
ICD-10 Finland
Pulmonary valve stenosis with insufficiency
+∞
25.2
24
*
74663
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae pulmonalis
+∞
25.2
24
*
WX892
NOMESCO Finland
Monitored bed care
5.0
24.5
84
195
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
131.5
23.8
25
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
131.5
23.8
25
*
XFE00
NOMESCO Finland
Epicardial ultrasonography
15.1
23.5
39
28
AEX
HP
Other pulmonary or pulmonary artery valve procedure
+∞
23.1
22
*
C07AB07
ATC
bisoprolol; oral
3.2
22.9
149
601
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
240.9
22.8
23
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
12.8
21.9
39
33
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
16.5
21.4
34
22
I49.5
ICD-10 Finland
Sick sinus syndrome
34.2
20.4
26
8
Q25.0
ICD-10 Finland
Patent ductus arteriosus
12.1
20.3
37
33
I50.9
ICD-10 Finland
Heart failure, unspecified
8.1
20.2
46
62
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
60.2
20.1
23
*
XF640
NOMESCO Finland
NA
16.2
20.0
32
21
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
19.9
19
*
FJD20
NOMESCO Finland
Bypass of pulmonary valve with ventriculopulmonary prosthesis or homograft
+∞
19.9
19
*
I44.2
ICD-10 Finland
Atrioventricular block, complete
21.1
19.3
28
14
G04BE03
ATC
sildenafil; oral
23.7
19.3
27
12
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
18.9
18
*
Q20.00
ICD-10 Finland
Common arterial trunk
+∞
18.9
18
*
Q87.14
ICD-10 Finland
Noonan's syndrome
197.2
18.7
19
*
FHE30
NOMESCO Finland
Repair of tetralogy of Fallot with transannular patch
197.2
18.7
19
*
C07AA07
ATC
sotalol; systemic
12.6
18.1
32
27
R07.4
ICD-10 Finland
Chest pain, unspecified
3.1
16.8
106
409
AF1
HP
Surgery of congenital heart defect
+∞
16.8
16
*
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
175.7
16.6
17
*
AP3
HP
Catheterization of the right and left side of the heart
175.7
16.6
17
*
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
31.2
16.2
21
7
I47.1
ICD-10 Finland
Supraventricular tachycardia
6.1
16.0
44
78
1EA01
NOMESCO Finland
NA
62.1
15.9
18
*
Q22.2
ICD-10 Finland
Congenital pulmonary valve insufficiency
+∞
15.7
15
*
TFP45
NOMESCO Finland
Ablation treatment of non-typical atrial flutter
+∞
15.7
15
*
Q25.1
ICD-10 Finland
Coarctation of aorta
12.9
15.5
27
22
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
18.5
15.3
23
13
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
15.3
115
492
Q21.0
ICD-10 Finland
Ventricular septal defect
58.5
14.9
17
*
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
4.1
14.8
59
157
XQ903
NOMESCO Finland
Production of other scan or drawing
26.0
14.8
20
8
AD1
HP
TVP
+∞
14.6
14
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
82.6
14.6
16
*
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
16.0
14.5
23
15
I47.2
ICD-10 Finland
Ventricular tachycardia
16.0
14.5
23
15
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
28.1
14.4
19
7
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.8
14.2
104
437
ZX120
NOMESCO Finland
Intravenous
3.4
14.1
72
237
C09AA02
ATC
enalapril; systemic
3.6
13.7
64
196
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
77.3
13.6
15
*
74709
ICD-8 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
+∞
13.6
13
*
FDB20
NOMESCO Finland
Arterial switch operation for other congenital heart defect
+∞
13.6
13
*
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
13.6
13
*
AP2
HP
Catheterization of the right side of the heart
143.7
13.5
14
*
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
143.7
13.5
14
*
FM1DM
NOMESCO Finland
Heart very extensive MRI examination with 3 Tesla magnet
143.7
13.5
14
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
18.9
13.5
20
11
AN1
HP
Coronary angiography
6.4
13.4
35
58
Q21.19
ICD-10 Finland
Atrial septal defect NOS
41.3
13.2
16
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
23.3
13.0
18
8
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.3
12.9
150
798
Q21.33
ICD-10 Finland
Fallots pentalogi
+∞
12.5
12
*
74699
ICD-8 Finland
Congenital anomalies of heart, Unspecified anomalies of heart
+∞
12.5
12
*
I28.8
ICD-10 Finland
Other specified diseases of pulmonary vessels
+∞
12.5
12
*
Q20.8
ICD-10 Finland
Other congenital malformations of cardiac chambers and connections
+∞
12.5
12
*
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
25.1
12.5
17
7
90492
NOMESCO Finland
NA
133.2
12.5
13
*
C07AB02
ATC
metoprolol; systemic
3.5
12.5
60
188
FM1BD
NOMESCO Finland
Extensive CT of heart
38.6
12.3
15
*
5253
FHL
Cardiac lung machine
38.6
12.3
15
*
WX402
NOMESCO Finland
General anaesthesia
2.4
12.2
125
627
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
5.0
12.1
39
84
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
10.4
12.1
23
23
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
11.9
99
444
TFP35
NOMESCO Finland
Electroanatomical mapping
19.5
11.7
17
9
FBA96
NOMESCO Finland
Other suture or repair of pulmonary artery
66.5
11.6
13
*
Q24.0
ICD-10 Finland
Dextrocardia
66.5
11.6
13
*
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
+∞
11.5
11
*
74734
ICD-8 Finland
Other congenital anomalies of circulatory system, Stenosis, hypoplasia sive aplasia arteriae pulmonalis
+∞
11.5
11
*
Q22.41
ICD-10 Finland
Tricuspid atresia
122.7
11.5
12
*
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
122.7
11.5
12
*
I50.0
ICD-10 Finland
Congestive heart failure
9.2
11.4
23
26
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
35.9
11.3
14
*
RS224
NOMESCO Finland
NA
7.1
11.3
27
40
C09AA05
ATC
ramipril; oral
3.2
11.2
62
214
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
25.7
11.2
15
6
WX704
NOMESCO Finland
Intubation
3.8
11.2
47
132
Q21.21
ICD-10 Finland
Atrioventricular duct
61.3
10.7
12
*
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
9.5
10.6
21
23
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
4.8
10.6
35
78
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
14.6
10.5
17
12
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
112.2
10.5
11
*
7454A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM NUD]
+∞
10.4
10
*
74689
ICD-8 Finland
Congenital anomalies of heart, Aliae definitae
+∞
10.4
10
*
5208
FHL
Total correction of Fallot's tetralogy
+∞
10.4
10
*
I44.1
ICD-10 Finland
Atrioventricular block, second degree
16.5
10.4
16
10
ZX199
NOMESCO Finland
Other rote
7.7
10.3
23
31
Q26.1
ICD-10 Finland
Persistent left superior vena cava
23.9
10.3
14
6
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
10.2
105
522
TFP34
NOMESCO Finland
Electrophysiological investigation
7.5
10.1
23
32
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
7.0
10.0
24
36
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
40.9
10.0
12
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
9.0
9.9
20
23
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
9.0
9.9
20
23
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
26.6
9.8
13
5
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
8.1
9.7
21
27
K84
ICPC
Heart disease other
10.3
9.6
18
18
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
30.7
9.4
12
*
FJF96
NOMESCO Finland
Other prosthetic replacement of pulmonary valve
+∞
9.4
9
*
AH3
HP
Treatment of arrhythmias, eg atrial fibrillation, in conjunction with other cardiac surgery
+∞
9.4
9
*
I48.4
ICD-10 Finland
Atypical atrial flutter
+∞
9.4
9
*
7452B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[DOUBLE OUTLET RIGHT VENTRICLE AND PULMONAL STENOSIS]
+∞
9.4
9
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
22.2
9.4
13
6
J01CA04
ATC
amoxicillin; systemic
2.4
9.3
417
3623
RK260
NOMESCO Finland
NA
14.0
9.2
15
11
WX002
NOMESCO Finland
Sedation and analgesia
2.5
9.2
76
338
7AX01
NOMESCO Finland
NA
10.3
9.1
17
17
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
19.0
9.0
13
7
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
8.9
94
471
I50.1
ICD-10 Finland
Left ventricular failure
7.9
8.7
19
25
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
50.9
8.7
10
*
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
50.9
8.7
10
*
C02EA02
ATC
NA
9.2
8.6
17
19
K83
ICPC
Heart valve disease NOS
28.0
8.5
11
*
F83
ICD-10 Finland
Mixed specific developmental disorders
3.8
8.4
35
98
FPH10
NOMESCO Finland
Open removal of transvenous cardiac pacemaker or cardioverter-defibrillator
91.5
8.4
9
*
FJD96
NOMESCO Finland
Other operation on right ventricle outlet for congenital or acquired obstruction
91.5
8.4
9
*
74642
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium secundum
91.5
8.4
9
*
PD5BG
NOMESCO Finland
MRI examination of thoracal and abdominal aortta with high intensity magnet
+∞
8.3
8
*
FBE96
NOMESCO Finland
Other expansion or reconstruction of pulmonary artery
+∞
8.3
8
*
FFE02
NOMESCO Finland
Percutaneous transluminal atrial septostomy
+∞
8.3
8
*
B34.9
ICD-10 Finland
Viral infection, unspecified
3.1
8.3
44
150
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
14.8
8.2
13
9
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
17.5
8.1
12
7
Q25.40
ICD-10 Finland
Aortic hypoplasia
17.5
8.1
12
7
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
17.5
8.1
12
7
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
33.9
8.1
10
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
33.9
8.1
10
*
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
22.4
8.0
11
5
Q23.11
ICD-10 Finland
Bicuspid aortic valve
7.4
8.0
18
25
B01AB05
ATC
enoxaparin; parenteral
2.2
7.8
83
417
XG460
NOMESCO Finland
Short time oxymetry
7.8
7.4
16
21
602
Kela drug reimbursment
Children's severe malnutrition
3.7
7.3
31
89
GD1AD
NOMESCO Finland
Thorax CT examination
5.3
7.3
21
41
Q25.8
ICD-10 Finland
Other congenital malformations of great arteries
+∞
7.3
7
*
74669
ICD-8 Finland
Congenital anomalies of heart, Aliae maleformationes valvulae pulmonaris sive ventriculi dextri
+∞
7.3
7
*
FHE00
NOMESCO Finland
Transatrial repair of tetralogy of Fallot
+∞
7.3
7
*
Q25.70
ICD-10 Finland
Aneurysm, congenital of pulmonary artery
+∞
7.3
7
*
7460B
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITUM CUM ATRESIA]
+∞
7.3
7
*
7468X
ICD-9 Finland
Other congenital anomalies of heart, Other specified anomalies of heart[MUU SYDÄMEN EPÄMUODOSTUMA]
+∞
7.3
7
*
FBE20
NOMESCO Finland
Reconstruction of pulmonary artery using tube graft
+∞
7.3
7
*
5269
FHL
Other measure in this category
+∞
7.3
7
*
7453B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Common ventricle[COMMON VENTRICLE]
+∞
7.3
7
*
7450A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Common truncus[TRUNCUS ARTERIOSUS COMMUNIS]
+∞
7.3
7
*
5504
FHL
Subclavian pulmonary anastomosis (Blalock)
+∞
7.3
7
*
5239
FHL
Other measure in this category
+∞
7.3
7
*
Q20.41
ICD-10 Finland
Double inlet right ventricle
+∞
7.3
7
*
Q22.6
ICD-10 Finland
Hypoplastic right heart syndrome
+∞
7.3
7
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.0
7.3
42
151
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
16.0
7.2
11
7
Z31.5
ICD-10 Finland
Genetic counselling
2.7
7.2
49
194
R04.0
ICD-10 Finland
Epistaxis
3.5
7.2
32
96
J96.1
ICD-10 Finland
Chronic respiratory failure
9.0
7.1
14
16
3A019
NOMESCO Finland
NA
9.0
7.1
14
16
R62.0
ICD-10 Finland
Delayed milestone
3.0
7.0
38
132
R06.0
ICD-10 Finland
Dyspnoea
2.1
7.0
80
414
R50.9
ICD-10 Finland
Fever, unspecified
2.0
7.0
100
567
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.3
7.0
33
104
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
3.1
7.0
36
121
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
14.0
6.9
11
8
Z94.1
ICD-10 Finland
Heart transplant status
11.1
6.8
12
11
UGC02
NOMESCO Finland
Rigid bronchoscopy
6.2
6.8
17
28
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
9.5
6.8
13
14
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
6.8
40
147
Q21.18
ICD-10 Finland
Other spedified atrial septal defect
40.6
6.8
8
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
40.6
6.8
8
*
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
40.6
6.8
8
*
1CX08
NOMESCO Finland
NA
17.0
6.8
10
6
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
3.1
6.8
35
118
I35.0
ICD-10 Finland
Aortic (valve) stenosis
7.3
6.7
15
21
Q21.20
ICD-10 Finland
Atrial septal defect of primum type
22.8
6.7
9
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.5
6.5
51
218
K78
ICPC
Atrial fibrillation/flutter
6.3
6.5
16
26
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.1
6.5
34
116
Q22.5
ICD-10 Finland
Ebstein anomaly
70.6
6.4
7
*
71
HP
Electrophysiological Special Examination
70.6
6.4
7
*
ZF61V
NOMESCO Finland
NA
70.6
6.4
7
*
FBJ00
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery
70.6
6.4
7
*
74
HP
Initial installation of the atrial pacemaker
70.6
6.4
7
*
Q20.9
ICD-10 Finland
Congenital malformation of cardiac chambers and connections, unspecified
70.6
6.4
7
*
Q22.40
ICD-10 Finland
Congenital tricuspid stenosis
70.6
6.4
7
*
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
6.7
6.4
15
23
81
HP
Angiography of the heart and coronary arteries
8.3
6.4
13
16
3A077
NOMESCO Finland
NA
11.2
6.3
11
10
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
11.2
6.3
11
10
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
18.3
6.3
9
5
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
18.3
6.3
9
5
I97.0
ICD-10 Finland
Postcardiotomy syndrome
18.3
6.3
9
5
7452C
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[PULMONARY ATRESIA AND VENTRICULAR SEPTAL DEFECT]
+∞
6.3
6
*
7461A
ICD-9 Finland
Other congenital anomalies of heart, Tricuspid atresia and stenosis, congenital[VITIUM VALVULAE TRICUSPIDALIS CONGENITUM CUM ATRESI]
+∞
6.3
6
*
I37.8
ICD-10 Finland
Other pulmonary valve disorders
+∞
6.3
6
*
73
HP
Initial pacemaker installation
+∞
6.3
6
*
XFP02
NOMESCO Finland
NA
+∞
6.3
6
*
Q21.4
ICD-10 Finland
Aortopulmonary septal defect
+∞
6.3
6
*
FPD96
NOMESCO Finland
Other operation for atrial fibrillation
+∞
6.3
6
*
7468B
ICD-9 Finland
Other congenital anomalies of heart, Other specified anomalies of heart[STENOSIS PULMONALIS INFUNDIBULARIS]
+∞
6.3
6
*
FMC96
NOMESCO Finland
Other operation on aortic valve for insufficiency
+∞
6.3
6
*
Q25.5
ICD-10 Finland
Atresia of pulmonary artery
+∞
6.3
6
*
FB1BC
NOMESCO Finland
Extensive angiography of arteria pulmonalis
+∞
6.3
6
*
FHB96
NOMESCO Finland
Other closure of congenital ventricular septal defect
+∞
6.3
6
*
Q22.3
ICD-10 Finland
Other congenital malformations of pulmonary valve
+∞
6.3
6
*
FBL96
NOMESCO Finland
Other connection to pulmonary artery from aorta
+∞
6.3
6
*
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
+∞
6.3
6
*
XX3BW
NOMESCO Finland
NA
27.0
6.2
8
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.0
6.2
84
465
WX870
NOMESCO Finland
Other postsurgical intensive care
12.7
6.1
10
8
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
6.8
6.1
14
21
I34.1
ICD-10 Finland
Mitral (valve) prolapse
10.2
6.1
11
11
RD210
NOMESCO Finland
NA
2.8
6.0
37
140
JDB10
NOMESCO Finland
Percutaneous gastrostomy
6.1
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
241
182
24.50
276.21
5.8
4.4
166.1
186.7
ng/l
0.23
226
162
360
541
20.89
270.07
8.0
5.0
851.9
886.9
ng/l
0.09
348
445
216
573
5.85
81.67
5.4
6.9
32.4
30.5
s
3.99
216
568
197
538
5.38
70.68
6.5
3.6
2766.0
769.4
ng/l
2.25
171
335
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
71
86
9.45
55.75
14.1
22.8
0.3
0.4
u/ml
1.26
51
51
232
890
3.98
50.54
3.3
3.0
—
—
—
0
0
249
1026
3.83
48.35
9.5
7.5
72.2
88.7
%
20.10
249
1013
174
564
4.19
47.78
12.4
10.9
0.8
0.8
mmol/l
0.15
167
540
63
80
8.86
47.48
3.0
6.1
81.5
98.0
%
3.23
63
80
65
92
7.97
44.70
1.4
1.5
—
—
—
0
0
87
177
5.73
42.06
1.7
2.4
23.9
8.7
ug/l
3.04
79
158
140
489
3.58
33.12
4.1
2.9
22.8
22.9
%
0.02
130
451
291
1587
2.98
31.56
4.5
4.3
—
—
—
0
0
68
149
5.12
29.92
20.9
17.0
—
—
—
0
0
95
280
3.95
28.58
18.6
12.3
1.1
0.5
mmol/l
0.70
87
228
26
20
13.65
27.32
2.5
6.0
—
—
—
0
0
171
753
2.93
26.68
4.0
4.0
1.5
1.5
mg/l
0.09
123
541
181
843
2.79
25.18
4.6
3.0
78.9
30.6
ng/l
0.94
115
429
276
1618
2.56
23.63
10.3
7.7
22.1
19.4
umol/l
0.65
265
1520
327
2125
2.54
21.74
12.4
6.9
6.1
6.3
mmol/l
1.18
315
1968
186
937
2.56
21.51
3.3
3.3
3.4
2.7
mg/l
1.46
170
821
74
224
3.70
21.16
43.4
16.1
2.2
1.2
inr
—
9
39
473
3805
5.08
19.99
28.5
13.2
139.3
139.5
mmol/l
1.21
473
3700
18
13
14.32
19.44
1.6
1.5
4770.2
2411.1
e6/l
—
12
8
17
11
15.96
19.43
1.6
1.5
100279.4
21535.0
e6/l
—
11
6
24
33
7.59
16.66
1.6
1.8
153.2
128.6
%
0.92
24
33
141
717
2.34
15.17
8.3
10.1
1.8
1.2
mmol/l
1.57
120
568
92
384
2.71
15.06
2.8
1.9
—
—
—
0
0
212
1279
2.14
14.92
8.3
7.6
35.9
37.3
g/l
2.45
204
1215
92
388
2.68
14.74
3.0
2.0
—
—
—
0
0
273
1821
2.09
14.62
16.8
11.4
1.2
1.2
mmol/l
3.69
259
1648
259
1706
2.07
14.22
20.6
11.7
1.2
1.2
mmol/l
7.20
250
1612
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
25
43
6.07
14.12
1.6
1.8
119.6
121.7
%
0.05
25
43
108
508
2.43
13.72
2.9
1.9
—
—
—
0
0
129
669
2.25
13.02
15.3
9.4
2.3
0.9
mmol/l
7.70
112
481
39
108
3.83
12.57
2.6
2.4
1.0
1.2
g/l
0.83
31
97
16
24
6.85
10.24
1.3
1.1
65.2
88.4
%
—
5
5
304
2276
1.85
9.99
10.0
8.8
27.7
33.6
%
17.51
295
2178
12
13
9.43
9.91
1.5
1.7
—
—
—
0
0
358
2833
1.91
9.75
18.6
8.6
97.7
96.4
ml/min/173m2
0.37
300
2123
254
1862
1.74
8.39
4.1
3.3
93.6
75.8
ug/l
1.21
246
1760
40
146
2.89
8.34
2.4
2.2
—
—
—
0
0
132
799
1.88
8.33
3.4
2.4
412.7
367.7
u/l
0.16
127
771
320
2516
1.75
8.10
11.5
11.4
3.8
3.7
e9/l
0.22
299
2113
31
99
3.27
8.09
1.9
1.9
—
—
—
0
0
39
143
2.87
8.07
2.5
2.1
—
—
—
0
0
23
62
3.84
7.71
1.4
1.3
—
—
—
0
0
90
497
1.99
7.39
4.7
6.1
8.7
8.5
umol/l
0.03
85
410
32
116
2.88
6.77
2.2
1.9
—
—
—
0
0
494
4668
4.26
6.76
34.0
17.4
136.0
136.2
g/l
0.08
494
4616
41
172
2.51
6.56
2.4
1.6
—
—
—
0
0
313
2528
1.63
6.41
10.2
6.5
95.2
101.9
u/l
1.09
305
2382
46
208
2.33
6.26
1.6
1.7
—
—
—
0
0
20
57
3.61
6.22
1.9
1.4
—
—
—
0
0
453
4072
2.13
6.21
23.4
11.6
24.5
22.4
mg/l
0.70
380
2919
27
94
2.98
6.14
2.1
2.0
—
—
—
0
0
27
94
2.98
6.14
2.5
4.0
—
—
—
0
0
24
79
3.14
6.00
1.3
1.2
1.5
3.6
u/ml
—
10
33
24
81
3.06
5.76
1.3
1.2
6.1
4.2
u/ml
—
10
37
23
78
3.04
5.48
1.2
1.1
—
—
—
0
0
41
188
2.29
5.42
3.8
3.0
65.8
79.4
ml/min/173m2
0.50
13
75
443
4016
1.86
4.95
13.3
9.4
27.2
28.8
u/l
0.93
433
3890
453
4138
1.95
4.91
30.3
14.4
39.5
40.2
%
1.33
405
3573
25
95
2.72
4.89
2.5
3.9
13.6
8.6
%
1.16
20
83
174
1296
1.52
4.61
4.5
4.1
—
—
—
0
0
33
148
2.32
4.61
6.8
7.3
24.9
24.6
mmol/l
0.25
33
143
39
188
2.16
4.60
2.5
2.1
110.8
93.6
u/ml
—
5
20
18
61
3.02
4.32
2.4
3.2
16.5
17.7
%
—
10
40
17
57
3.05
4.16
1.6
1.6
—
—
—
0
0
45
240
1.96
4.08
5.4
3.6
4.8
4.9
pmol/l
0.07
40
219
38
191
2.07
4.05
2.5
2.0
—
—
—
0
0
22
87
2.60
4.02
1.7
1.6
—
—
—
0
0
150
1111
1.50
3.99
4.3
3.9
0.5
0.3
e6/l
0.74
118
819
10
24
4.23
3.90
1.5
1.2
—
—
—
0
0
28
128
2.26
3.77
15.0
11.7
295.5
402.8
iu/ml
—
6
22
24
109
2.26
3.31
1.2
1.5
—
—
—
0
0
132
995
1.44
3.13
3.2
3.3
2.4
2.4
mmol/l
0.49
122
897
14
51
2.80
3.01
1.7
1.6
—
—
—
0
0
123
926
1.43
2.92
3.6
2.8
49.3
57.3
u/l
1.89
117
862
97
699
1.48
2.89
2.9
3.6
2.9
2.0
e6/l
0.39
56
397
6
9
6.73
2.87
3.8
4.0
—
—
—
0
0
17
71
2.44
2.83
2.2
1.8
—
—
—
0
0
111
1449
0.70
2.79
1.5
1.6
0.9
2.7
u/ml
2.56
31
281
6
10
6.06
2.70
1.8
1.2
11.2
15.1
u/l
—
6
10
9
24
3.80
2.68
1.6
1.7
—
—
—
0
0
20
93
2.20
2.64
2.2
1.7
—
—
—
0
0
265
2287
1.34
2.64
4.9
3.9
14.5
566.0
e6/l
—
6
25
348
3793
0.73
2.59
4.0
3.8
—
—
—
0
0
18
82
2.24
2.50
5.2
4.4
56.4
52.6
%
0.46
18
82
15
63
2.42
2.48
1.4
1.4
—
—
—
0
0
37
222
1.72
2.38
1.6
1.7
—
—
—
0
0
12
46
2.65
2.37
2.5
1.3
—
—
—
0
0
19
91
2.13
2.36
2.5
1.8
—
—
—
0
0
39
240
1.68
2.30
3.6
2.6
—
—
—
0
0
41
259
1.63
2.20
7.3
5.6
—
—
—
0
0
24
419
0.55
2.18
1.1
1.1
—
—
—
0
0
8
25
3.23
2.10
8.3
8.2
—
—
—
0
0
88
663
1.40
2.06
6.0
4.1
5758.3
3534.2
umol/l
0.16
83
602
16
76
2.14
2.04
2.9
2.0
—
—
—
0
0
9
32
2.84
2.01
1.2
1.7
—
—
—
0
0
9
32
2.84
2.01
1.2
1.7
—
—
—
0
0
9
32
2.84
2.01
1.2
1.7
—
—
—
0
0
54
374
1.50
1.97
1.5
2.4
2.4
2.4
mmol/l
0.55
45
319
5
141
0.35
1.91
1.0
4.2
405.6
364.6
e6/l
—
5
106
7
22
3.21
1.88
5.7
3.2
—
—
—
0
0
9
34
2.68
1.87
7.4
10.9
—
—
—
0
0
10
40
2.53
1.84
2.2
2.4
—
—
—
0
0
7
165
0.42
1.82
1.7
1.7
39.4
36.3
nmol/l
—
7
159
9
36
2.53
1.74
2.4
1.5
—
—
—
0
0
16
82
1.98
1.71
4.8
3.8
3.9
3.5
e9/l
0.22
16
82
0
47
0.00
1.71
0.0
1.3
—
—
—
0
0
91
712
1.34
1.70
3.1
3.4
1.0
0.6
e6/l
0.61
51
408
22
127
1.77
1.67
1.5
1.5
—
—
—
0
0
22
127
1.77
1.67
1.5
1.5
—
—
—
0
0
8
31
2.61
1.66
3.6
2.8
949.6
1055.9
u/ml
—
8
31
47
329
1.47
1.66
1.5
1.6
1065.8
1184.0
nmol/l
0.46
38
252
7
25
2.82
1.65
1.6
1.2
—
—
—
0
0
69
897
0.73
1.62
1.8
2.1
—
—
—
0
0
62
461
1.39
1.59
1.4
1.5
462.6
16184028.8
pmol/l
0.50
54
414
49
350
1.44
1.57
2.2
2.5
28.4
31.5
u/l
0.33
39
291
16
85
1.91
1.56
1.4
1.7
—
—
—
0
0
25
386
0.63
1.46
3.0
2.2
10.5
12.9
nmol/l
0.76
25
332
21
125
1.71
1.46
1.3
1.2
—
—
—
0
0
299
2742
1.22
1.42
4.9
4.3
36.9
38.1
mmol/mol
1.58
283
2596
6
23
2.63
1.37
1.3
1.1
—
—
—
0
0
5
17
2.96
1.36
1.0
1.5
—
—
—
0
0
33
225
1.50
1.35
2.6
2.0
214.9
183.2
u/ml
0.29
24
111
5
18
2.79
1.29
1.0
1.6
1.0
0.9
g/l
—
5
18
5
18
2.79
1.29
1.0
1.6
—
—
—
0
0
79
971
0.78
1.24
1.9
2.3
—
—
—
0
0
7
145
0.48
1.22
1.0
4.0
430.9
424.8
mg/l
—
7
138
13
222
0.57
1.17
1.3
1.9
—
—
—
0
0
21
134
1.59
1.16
1.1
1.1
—
—
—
0
0
7
30
2.35
1.12
6.0
6.7
—
—
—
0
0
7
30
2.35
1.12
7.7
6.7
—
—
—
0
0
7
138
0.50
1.11
1.0
4.0
3.8
3.4
mmol/l
—
7
130
32
227
1.44
1.11
2.5
2.0
—
—
—
0
0
21
137
1.56
1.07
1.1
1.1
—
—
—
0
0
16
98
1.65
1.04
1.8
1.9
—
—
—
0
0
17
106
1.62
1.04
2.3
1.9
3.1
5.3
iu/l
—
5
34
20
297
0.66
1.03
1.2
1.3
17.8
2.1
u/ml
1.25
15
192
14
221
0.62
0.95
1.0
1.4
—
—
—
0
0
6
28
2.16
0.91
1.2
1.8
—
965650.0
—
0
5
312
2937
1.16
0.90
4.4
3.7
15.4
14.5
pmol/l
6.58
290
2728
19
127
1.52
0.90
1.1
3.0
—
—
—
0
0
6
29
2.08
0.89
2.5
4.1
183.8
199.7
ug/l
—
6
29
315
2977
1.16
0.83
3.9
3.3
1.3
1.2
mmol/l
0.43
297
2796
20
283
0.69
0.83
3.9
3.4
29.3
31.1
%
0.33
12
197
17
247
0.68
0.81
1.5
1.4
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
0
25
0.00
0.79
0.0
1.0
—
—
—
0
0
22
302
0.72
0.78
2.1
2.3
0.4
0.7
ug/l
2.44
12
157
0
28
0.00
0.76
0.0
2.2
—
—
—
0
0
14
91
1.55
0.76
1.6
1.7
—
—
—
0
0
283
2669
1.14
0.73
6.5
4.3
7.9
8.6
mm/h
0.55
269
2481
11
68
1.63
0.72
1.0
1.0
160.3
163.2
g/l
0.21
11
68
5
27
1.86
0.68
1.8
1.6
—
—
—
0
0
112
1249
0.87
0.65
4.3
3.2
—
—
—
0
0
10
153
0.65
0.63
1.9
1.7
—
—
—
0
0
74
642
1.18
0.62
4.5
4.1
20.5
35.5
mg/mmol
0.25
52
447
9
138
0.65
0.61
1.4
1.5
—
—
—
0
0
94
833
1.16
0.61
1.8
1.8
1.5
1.4
mmol/l
0.47
87
739
0
20
0.00
0.60
0.0
1.5
—
1.7
—
0
11
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
23
175
1.33
0.59
2.0
1.4
—
—
—
0
0
6
35
1.72
0.58
1.2
1.2
—
—
—
0
0
8
54
1.49
0.57
1.1
1.1
—
—
—
0
0
62
535
1.18
0.56
1.2
1.2
17.3
21.5
iu/ml
0.33
19
153
10
65
1.55
0.56
1.5
2.2
—
—
—
0
0
8
125
0.63
0.55
1.1
2.0
—
—
—
0
0
9
60
1.51
0.54
1.6
1.9
—
—
—
0
0
9
61
1.48
0.54
1.3
1.7
—
—
—
0
0
25
312
0.79
0.50
1.7
2.6
14809.1
3474.1
u/l
—
7
122
19
245
0.77
0.49
1.1
1.2
—
—
—
0
0
13
175
0.74
0.45
1.4
1.6
—
—
—
0
0
324
3129
1.10
0.45
4.2
3.5
4.3
4.6
mmol/l
4.35
310
2950
25
304
0.81
0.42
2.8
2.0
6.1
6.3
u/l
0.03
18
218
354
3440
1.10
0.41
5.1
4.2
2.1
1.9
mu/l
2.19
336
3230
5
33
1.52
0.41
1.0
1.2
82.3
231.7
iu/ml
—
5
33
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
19.5
—
0
16
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.6
—
—
—
0
0
5
34
1.48
0.40
1.2
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
3.1
—
91.1
—
0
18
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
5
36
1.39
0.38
1.4
1.6
—
—
—
0
0
33
384
0.85
0.36
1.5
1.5
—
—
—
0
0
11
145
0.75
0.35
1.0
1.0
21.2
19.3
mmol/l
2.20
11
145
6
45
1.34
0.34
4.5
5.6
—
—
—
0
0
6
46
1.31
0.33
1.5
3.4
25.8
25.1
ug/l
—
6
46
6
89
0.67
0.33
1.7
5.0
415.5
390.7
umol/l
—
6
81
7
53
1.33
0.31
1.1
4.7
—
—
—
0
0
7
53
1.33
0.31
1.1
4.7
—
—
—
0
0
7
54
1.30
0.30
1.1
1.2
81.6
75.5
%
—
7
54
7
54
1.30
0.30
1.1
1.2
—
—
—
0
0
8
107
0.74
0.29
1.1
1.3
14.4
4.7
ug/l
—
8
97
33
289
1.15
0.28
1.7
1.2
—
—
—
0
0
33
374
0.87
0.28
1.4
1.5
—
—
—
0
0
59
539
1.11
0.27
1.4
1.5
—
—
—
0
0
306
2983
1.07
0.27
3.5
3.2
5.7
5.7
mmol/l
0.03
289
2749
5
73
0.68
0.26
1.4
1.2
—
—
—
0
0
5
75
0.66
0.26
1.2
1.4
—
—
—
0
0
36
402
0.89
0.25
2.9
3.4
28.6
21.9
%
0.84
12
143
320
3130
1.06
0.24
4.5
3.7
2.7
2.8
mmol/l
1.38
301
2931
317
3102
1.06
0.23
4.2
3.5
1.3
1.4
mmol/l
4.81
300
2912
11
136
0.80
0.23
1.1
1.1
—
—
—
0
0
21
181
1.17
0.23
1.3
1.3
—
—
—
0
0
5
41
1.22
0.22
1.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
158
1522
1.06
0.20
4.0
3.2
71.3
72.0
nmol/l
0.12
146
1423
6
48
1.25
0.20
1.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
2.9
—
—
—
0
0
8
72
1.11
0.16
1.1
1.2
—
—
—
0
0
40
431
0.92
0.16
1.5
1.9
—
—
—
0
0
93
971
0.95
0.15
1.7
1.7
89.0
95.9
pmol/l
0.95
49
494
6
79
0.76
0.15
1.0
1.3
52.3
194.7
pmol/l
—
6
74
89
852
1.05
0.15
4.6
3.5
0.1
0.0
estimate
0.42
31
313
150
1544
0.96
0.14
1.7
1.9
—
—
—
0
0
248
2434
1.04
0.14
4.1
4.0
53.7
37.3
u/l
2.88
238
2343
55
520
1.06
0.13
1.2
1.2
15.1
6.6
u/ml
0.28
20
191
17
189
0.90
0.12
1.2
1.4
158.0
273.7
miu/ml
—
6
94
25
231
1.09
0.11
1.5
1.8
—
—
—
0
0
50
525
0.95
0.10
2.9
3.4
0.9
1.5
ug/l
4.28
44
481
5
44
1.14
0.10
1.8
1.1
—
—
—
0
0
174
1771
0.97
0.09
3.9
3.4
0.0
0.0
estimate
0.00
32
307
5
62
0.80
0.08
1.8
2.1
0.2
0.1
nmol/l
—
5
51
35
333
1.05
0.07
1.2
1.3
83.9
172.2
iu/ml
0.99
12
117
11
122
0.90
0.07
1.5
2.2
1.8
0.5
nmol/l
1.01
11
108
20
214
0.93
0.07
1.3
1.3
—
—
—
0
0
9
88
1.02
0.07
2.7
4.4
19.1
18.9
u/ml
—
9
82
176
1738
1.02
0.05
3.9
3.3
0.0
0.0
estimate
0.00
33
304
173
1751
0.98
0.05
5.3
4.9
0.0
0.0
estimate
0.00
34
323
18
190
0.95
0.04
1.6
1.4
—
—
—
0
0
18
190
0.95
0.04
1.6
1.4
—
—
—
0
0
18
189
0.95
0.03
1.6
1.4
—
—
—
0
0
18
189
0.95
0.03
1.6
1.4
—
—
—
0
0
13
126
1.03
0.00
1.1
2.0
—
—
—
0
0
15
154
0.97
0.00
1.8
1.8
18.4
3.1
mg/l
—
10
98
21
208
1.01
0.00
1.4
1.5
—
—
—
0
0
5
56
0.89
0.00
1.0
1.1
—
—
—
0
0
6
59
1.02
0.00
4.7
1.3
—
—
—
0
0
5
49
1.02
0.00
1.0
2.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
54
540
1.00
0.00
1.5
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
16.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
7
78
0.90
0.00
1.1
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
346.3
—
0
7
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
4.3
—
3.7
—
0
7
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONOTR_DEFEC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONOTR_DEFEC | 5.183 [3.58, 7.5] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.185 |
During the follow-up period (1.1.1998 — 31.12.2019), 107 out of 1995 females with Q17_CONOTR_DEFEC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONOTR_DEFEC | 5.139 [3.95, 6.69] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 145 out of 1886 males with Q17_CONOTR_DEFEC died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONOTR_DEFEC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.538% | 0.792% |
| 5 | 2.78% | 5.754% |
| 10 | 7.43% | 14.799% |
| 15 | 14.02% | 25.698% |
| 20 | 23.042% | 39.601% |
Relationships between endpoints
↥Index endpoint: Q17_CONOTR_DEFEC – Conotruncal defects
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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