No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
504 |
4. Check minimum number of eventsNone |
504 |
5. Include endpointsNone |
504 |
6. Filter based on genotype QC (FinnGen only) |
465 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Conotruncal defects
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5696 | 2805 | 2877 |
| Only index persons | 3689 | 1836 | 1853 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 0.60 | 0.54 | 0.45 |
| Only index persons | 2.47 | 3.18 | 1.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 465 | 224 | 241 |
| Unadjusted period prevalence (%) | 0.10 | 0.08 | 0.11 |
| Median age at first event (years) | 6.82 | 10.36 | 3.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 503
- Matched controls
- 5030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
20.2
266.4
283
301
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
32.4
257.7
184
88
201
Kela drug reimbursment
Chronic cardiac insufficiency
46.0
255.9
159
50
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
26.1
255.5
205
129
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
54.0
239.0
141
36
XF404
NOMESCO Finland
Ambulatory ECG
23.0
237.7
203
144
XF402
NOMESCO Finland
ECG with work load test
23.0
213.3
176
115
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
190.0
170
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
11.6
175.7
294
545
C01AA05
ATC
digoxin; systemic
38.6
167.9
107
35
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
81.4
152.9
82
12
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
149.7
136
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
25.7
146.5
108
53
B01AA03
ATC
warfarin; systemic
14.1
143.1
152
150
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
88.0
141.5
75
10
C03CA01
ATC
furosemide; systemic
10.9
140.8
194
275
XF400
NOMESCO Finland
ECG with 12 standard connections
9.3
140.4
253
493
C03DA01
ATC
spironolactone; oral
13.9
137.2
146
144
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
130.0
119
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.1
125.4
160
203
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
39.2
113.6
71
21
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
50.5
112.7
66
15
TPH07
NOMESCO Finland
Cathetrisation of artery
9.3
111.7
167
256
FM2CE, ,
NOMESCO Finland
11.7
106.6
124
137
ZXE20
NOMESCO Finland
More than three and less than five hours
8.0
103.3
180
326
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.9
99.7
336
1141
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
21.1
96.9
76
42
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
20.5
96.7
77
44
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.1
95.2
194
410
Z2221
NOMESCO Finland
Medical doctor
5.9
88.5
287
919
Q21.10
ICD-10 Finland
Persistent ostium secundum
17.9
87.2
74
48
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
22.2
86.5
66
34
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
27.8
82.1
57
23
ZXE30
NOMESCO Finland
More than five and less than seven hours
9.7
81.5
107
137
Z98.8
ICD-10 Finland
Other specified postsurgical states
39.5
80.6
50
14
ZXD10
NOMESCO Finland
Scheduled procedure
5.1
71.0
314
1241
TFP20
NOMESCO Finland
Cardiodefibrillation
13.9
68.0
66
54
31
HP
Congenital heart failure surgery
137.4
67.8
71
6
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
+∞
67.2
63
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
7.9
66.0
102
157
ZXE40
NOMESCO Finland
More than seven and less than nine hours
13.2
64.0
64
55
XF600
NOMESCO Finland
Bloodpressure measurement
6.1
62.2
129
268
WX408
NOMESCO Finland
General anesthesy, balanced
4.5
60.7
252
923
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
60.7
57
*
WX872
NOMESCO Finland
Intensive care
13.5
60.1
59
49
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
59.6
56
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
6.5
59.5
113
215
I48
ICD-10 Finland
Atrial fibrillation and flutter
7.5
58.0
92
145
C01BD01
ATC
amiodarone; systemic
21.8
58.0
44
22
62
HP
Catheterization and pressure measurement of the right side of the heart
218.0
57.3
58
*
74629
ICD-8 Finland
Congenital anomalies of heart, Tetralogy of Fallot
613.3
56.8
55
*
61
HP
Catheterization and pressure measurement of the left side of the heart
78.2
55.6
62
9
207
Kela drug reimbursment
Chronic arrhythmias
8.6
55.0
76
102
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
84.7
54.4
60
8
ZXE10
NOMESCO Finland
More than one and less than three hours
4.1
54.0
263
1061
XFE00
NOMESCO Finland
Epicardial ultrasonography
15.3
49.9
45
32
C07AA07
ATC
sotalol; systemic
19.5
47.8
38
21
WX882
NOMESCO Finland
High dependency care
5.6
47.2
103
221
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
17.5
46.6
39
24
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
16.6
46.5
40
26
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
65.6
46.3
53
9
R4110
NOMESCO Finland
Physiotherapy
3.7
45.5
229
922
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
12.6
45.3
46
40
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
+∞
43.4
41
*
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
98.7
41.5
45
5
I50.9
ICD-10 Finland
Heart failure, unspecified
7.6
41.2
62
91
XF640, ,
NOMESCO Finland
17.3
40.4
34
21
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
40.1
38
*
Q21.3
ICD-10 Finland
Tetralogy of Fallot
+∞
40.1
38
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.5
39.4
194
758
7452A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[TETRALOGIA FALLOT]
+∞
39.1
37
*
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
39.1
37
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
5.8
38.1
76
149
7451A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[TRANSPOSITIO CORDIS COMPLETA]
+∞
38.0
36
*
FJF10
NOMESCO Finland
Replacement of pulmonary valve using biological prosthesis
+∞
38.0
36
*
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
+∞
38.0
36
*
WX892
NOMESCO Finland
Monitored bed care
5.0
37.3
90
209
Q25.0
ICD-10 Finland
Patent ductus arteriosus
11.7
35.9
38
35
ZXD05
NOMESCO Finland
Urgent procedure
3.2
35.0
208
900
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
129.0
34.1
36
*
7460C
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITA CUM STENOSIS]
+∞
33.7
32
*
74619
ICD-8 Finland
Congenital anomalies of heart, Transposition of great vessels
+∞
33.7
32
*
C07AB07
ATC
bisoprolol; oral
3.2
32.5
179
735
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
77.2
32.3
36
5
XF620
NOMESCO Finland
Examination of circulation with color method
64.4
31.5
36
6
Z3231
NOMESCO Finland
Registered nurse
3.0
31.1
237
1164
XF622
NOMESCO Finland
Measurement of minute volume of heart
55.2
30.8
36
7
ZXE00
NOMESCO Finland
One hour or less
2.9
30.2
266
1406
I47.1
ICD-10 Finland
Supraventricular tachycardia
6.5
29.6
51
86
Q20.48
ICD-10 Finland
Single ventricle
109.9
29.0
31
*
Q21.32
ICD-10 Finland
Pulmonary atresia with Fallot ventricular septal defect
+∞
28.4
27
*
Q21.31
ICD-10 Finland
Tetralogy of Fallot and double outlet right ventricle
+∞
28.4
27
*
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
45.4
28.1
34
8
I37.2
ICD-10 Finland
Pulmonary valve stenosis with insufficiency
+∞
27.3
26
*
Z3226
NOMESCO Finland
Physiotherapist
3.0
26.8
166
718
ZX120
NOMESCO Finland
Intravenous
4.2
26.3
79
216
I50.0
ICD-10 Finland
Congestive heart failure
9.0
26.0
33
39
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
274.0
25.9
26
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
35.2
25.9
33
10
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
6.1
25.2
46
82
RS224, ,
NOMESCO Finland
10.2
25.2
29
30
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
25.2
24
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
262.5
24.9
25
*
74663
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae pulmonalis
262.5
24.9
25
*
I44.2
ICD-10 Finland
Atrioventricular block, complete
21.4
24.7
36
18
I50.1
ICD-10 Finland
Left ventricular failure
10.2
24.3
28
29
AEX
HP
Other pulmonary or pulmonary artery valve procedure
+∞
24.2
23
*
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
71.1
24.1
27
*
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
91.3
23.9
26
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
23.7
133
540
G04BE03
ATC
sildenafil; oral
23.4
23.3
33
15
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
42.3
22.9
28
7
C09AA05
ATC
ramipril; oral
3.6
22.4
82
256
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
8.9
22.1
28
33
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
24.4
21.5
30
13
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
21.0
20
*
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
21.0
20
*
Q20.00
ICD-10 Finland
Common arterial trunk
+∞
21.0
20
*
I49.5
ICD-10 Finland
Sick sinus syndrome
16.7
20.9
33
21
AP3
HP
Catheterization of the right and left side of the heart
218.7
20.7
21
*
WX402
NOMESCO Finland
General anaesthesia
2.6
20.3
165
803
AN1
HP
Coronary angiography
5.7
20.3
39
73
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
7.6
20.1
29
40
FJD20
NOMESCO Finland
Bypass of pulmonary valve with ventriculopulmonary prosthesis or homograft
+∞
19.9
19
*
FHE30
NOMESCO Finland
Repair of tetralogy of Fallot with transannular patch
+∞
19.9
19
*
1EA01, ,
NOMESCO Finland
+∞
19.9
19
*
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
8.5
19.8
26
32
C09AA02
ATC
enalapril; systemic
3.6
19.5
70
215
Q25.1
ICD-10 Finland
Coarctation of aorta
16.4
19.5
31
20
R07.4
ICD-10 Finland
Chest pain, unspecified
2.8
19.4
124
534
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
+∞
18.9
18
*
FM1DM
NOMESCO Finland
Heart very extensive MRI examination with 3 Tesla magnet
+∞
18.9
18
*
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
197.0
18.7
19
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
5.8
18.6
35
64
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
23.8
17.9
25
11
TFP45
NOMESCO Finland
Ablation treatment of non-typical atrial flutter
+∞
17.8
17
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
186.3
17.6
18
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.7
17.6
113
486
Q87.14
ICD-10 Finland
Noonan's syndrome
43.7
17.4
21
5
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
5.7
17.4
33
61
TFP34
NOMESCO Finland
Electrophysiological investigation
7.2
17.1
26
38
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
22.8
17.0
24
11
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
3.3
16.8
71
242
FDB20
NOMESCO Finland
Arterial switch operation for other congenital heart defect
+∞
16.8
16
*
Q22.2
ICD-10 Finland
Congenital pulmonary valve insufficiency
+∞
16.8
16
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.2
16.2
69
236
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
+∞
15.7
15
*
AP2
HP
Catheterization of the right side of the heart
+∞
15.7
15
*
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
14.4
15.7
26
19
AF1
HP
Surgery of congenital heart defect
164.9
15.6
16
*
FBA96
NOMESCO Finland
Other suture or repair of pulmonary artery
164.9
15.6
16
*
FM1BD
NOMESCO Finland
Extensive CT of heart
46.5
15.2
18
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
15.0
121
578
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
32.8
14.9
19
6
AD1
HP
TVP
+∞
14.7
14
*
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
82.6
14.6
16
*
5253
FHL
Cardiac lung machine
82.6
14.6
16
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
17.6
14.4
22
13
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
28.1
14.4
19
7
XQ903
NOMESCO Finland
Production of other scan or drawing
23.1
14.3
20
9
Q21.0
ICD-10 Finland
Ventricular septal defect
31.0
14.0
18
6
B01AB05
ATC
enoxaparin; parenteral
2.5
13.9
106
491
I47.2
ICD-10 Finland
Ventricular tachycardia
10.9
13.9
26
25
Z2446
NOMESCO Finland
Social worker
2.6
13.8
93
407
C07AB02
ATC
metoprolol; systemic
3.0
13.7
68
253
I48.4
ICD-10 Finland
Atypical atrial flutter
77.3
13.6
15
*
Q21.33
ICD-10 Finland
Fallots pentalogi
+∞
13.6
13
*
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
13.6
13
*
Q24.0
ICD-10 Finland
Dextrocardia
143.7
13.5
14
*
74709
ICD-8 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
143.7
13.5
14
*
Q20.8
ICD-10 Finland
Other congenital malformations of cardiac chambers and connections
143.7
13.5
14
*
WX002
NOMESCO Finland
Sedation and analgesia
2.6
13.4
85
360
WX704
NOMESCO Finland
Intubation
3.4
13.3
50
158
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
12.6
13.2
23
19
R04.0
ICD-10 Finland
Epistaxis
3.9
13.2
40
109
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
5.7
13.2
25
46
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
13.0
106
505
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
19.7
13.0
19
10
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
23.3
13.0
18
8
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
13.0
121
612
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.1
12.9
171
994
ZX199
NOMESCO Finland
Other rote
11.4
12.6
23
21
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
11.4
12.6
23
21
I28.8
ICD-10 Finland
Other specified diseases of pulmonary vessels
+∞
12.5
12
*
74734
ICD-8 Finland
Other congenital anomalies of circulatory system, Stenosis, hypoplasia sive aplasia arteriae pulmonalis
+∞
12.5
12
*
Q22.41
ICD-10 Finland
Tricuspid atresia
+∞
12.5
12
*
FK1AC
NOMESCO Finland
Right cardioangiography
+∞
12.5
12
*
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
25.0
12.5
17
7
Q21.19
ICD-10 Finland
Atrial septal defect NOS
25.0
12.5
17
7
90492, ,
NOMESCO Finland
133.2
12.5
13
*
74699
ICD-8 Finland
Congenital anomalies of heart, Unspecified anomalies of heart
133.2
12.5
13
*
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
38.6
12.3
15
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
4.0
12.1
35
92
I44.1
ICD-10 Finland
Atrioventricular block, second degree
21.9
12.1
17
8
Q26.1
ICD-10 Finland
Persistent left superior vena cava
47.9
11.9
14
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.8
11.8
37
103
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
3.7
11.8
39
113
TFP35
NOMESCO Finland
Electroanatomical mapping
13.0
11.7
20
16
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.8
11.7
36
99
5208
FHL
Total correction of Fallot's tetralogy
+∞
11.5
11
*
74642
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium secundum
+∞
11.5
11
*
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
+∞
11.5
11
*
7454A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM NUD]
+∞
11.5
11
*
74689
ICD-8 Finland
Congenital anomalies of heart, Aliae definitae
+∞
11.5
11
*
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
+∞
11.5
11
*
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
12.2
11.4
20
17
K84
ICPC
Heart disease other
9.9
11.4
22
23
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
35.9
11.3
14
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
4.0
11.3
32
83
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.5
11.2
40
122
K78
ICPC
Atrial fibrillation/flutter
5.6
11.0
21
39
7AX01, ,
NOMESCO Finland
15.9
10.9
17
11
RK260, ,
NOMESCO Finland
22.0
10.7
15
7
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
10.7
52
191
WZC00
NOMESCO Finland
Treatment plan or consultation
1.9
10.5
215
1430
B34.9
ICD-10 Finland
Viral infection, unspecified
3.0
10.5
47
165
1CX08, ,
NOMESCO Finland
112.3
10.5
11
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
+∞
10.4
10
*
602
Kela drug reimbursment
Children's severe malnutrition
3.8
10.4
32
88
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.8
10.4
55
212
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
33.3
10.4
13
*
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
23.9
10.3
14
6
F83
ICD-10 Finland
Mixed specific developmental disorders
3.4
10.2
37
114
GD1AD
NOMESCO Finland
Thorax CT examination
3.9
10.0
30
81
Q21.21
ICD-10 Finland
Atrioventricular duct
40.9
10.0
12
*
J96.1
ICD-10 Finland
Chronic respiratory failure
12.5
9.9
17
14
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
9.0
9.9
20
23
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
26.6
9.9
13
5
Q25.40
ICD-10 Finland
Aortic hypoplasia
20.5
9.8
14
7
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
9.8
9.8
19
20
205
Kela drug reimbursment
Chronic hypertension
2.6
9.7
58
238
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
56.1
9.7
11
*
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
56.1
9.7
11
*
XX3BW, ,
NOMESCO Finland
56.1
9.7
11
*
B01AF02
ATC
apixaban; oral
3.7
9.7
31
88
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.6
9.5
32
94
Q20.9
ICD-10 Finland
Congenital malformation of cardiac chambers and connections, unspecified
101.9
9.4
10
*
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
30.7
9.4
12
*
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
30.7
9.4
12
*
7460B
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITUM CUM ATRESIA]
+∞
9.4
9
*
AH3
HP
Treatment of arrhythmias, eg atrial fibrillation, in conjunction with other cardiac surgery
+∞
9.4
9
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
9.4
9
*
5239
FHL
Other measure in this category
+∞
9.4
9
*
7453B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Common ventricle[COMMON VENTRICLE]
+∞
9.4
9
*
7452B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[DOUBLE OUTLET RIGHT VENTRICLE AND PULMONAL STENOSIS]
+∞
9.4
9
*
FJF96
NOMESCO Finland
Other prosthetic replacement of pulmonary valve
+∞
9.4
9
*
7451X
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[MUU TRANSPOSITIO]
+∞
9.4
9
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
3.3
9.4
35
110
R06.0
ICD-10 Finland
Dyspnoea
2.1
9.3
106
574
Z94.1
ICD-10 Finland
Heart transplant status
11.8
9.1
16
14
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.9
9.1
43
156
K83
ICPC
Heart valve disease NOS
37.4
9.0
11
*
FPH10
NOMESCO Finland
Open removal of transvenous cardiac pacemaker or cardioverter-defibrillator
37.4
9.0
11
*
Z3229
NOMESCO Finland
Other healthcare associate professional
2.4
9.0
63
279
R50.9
ICD-10 Finland
Fever, unspecified
2.0
8.9
115
650
3A019, ,
NOMESCO Finland
14.4
8.7
14
10
J01CA04
ATC
amoxicillin; systemic
2.5
8.7
457
4007
ZX108
NOMESCO Finland
Inhalation
8.4
8.6
18
22
UGC02
NOMESCO Finland
Rigid bronchoscopy
9.2
8.6
17
19
FJD96
NOMESCO Finland
Other operation on right ventricle outlet for congenital or acquired obstruction
91.5
8.4
9
*
XFP02, ,
NOMESCO Finland
91.5
8.4
9
*
PD5BG
NOMESCO Finland
MRI examination of thoracal and abdominal aortta with high intensity magnet
91.5
8.4
9
*
Z31.5
ICD-10 Finland
Genetic counselling
2.5
8.4
57
248
Q22.40
ICD-10 Finland
Congenital tricuspid stenosis
+∞
8.4
8
*
Q25.8
ICD-10 Finland
Other congenital malformations of great arteries
+∞
8.4
8
*
FBE20
NOMESCO Finland
Reconstruction of pulmonary artery using tube graft
+∞
8.4
8
*
ZF61V, ,
NOMESCO Finland
+∞
8.4
8
*
R62.0
ICD-10 Finland
Delayed milestone
2.9
8.3
39
141
Q23.11
ICD-10 Finland
Bicuspid aortic valve
6.7
8.3
20
31
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.0
8.2
94
508
FN1AD
NOMESCO Finland
CT of coronary arteries
12.0
8.1
14
12
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
10.3
8.1
15
15
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.3
8.1
30
94
3A077, ,
NOMESCO Finland
22.4
8.0
11
5
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
22.4
8.0
11
5
RD210, ,
NOMESCO Finland
2.9
8.0
38
138
127
Kela drug reimbursment
Transplant complication
3.8
8.0
24
65
XG460
NOMESCO Finland
Short time oxymetry
8.0
7.9
17
22
C02EA02, ,
ATC
8.0
7.9
17
22
K99
ICPC
Cardiovascular disease other
13.3
7.9
13
10
TLC00
NOMESCO Finland
Insertion of intrauterine device
3.0
7.9
35
122
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.4
7.7
19
44
FFE02
NOMESCO Finland
Percutaneous transluminal atrial septostomy
45.7
7.7
9
*
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
45.7
7.7
9
*
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
45.7
7.7
9
*
FM1AD
NOMESCO Finland
CT of heart
45.7
7.7
9
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.2
7.7
67
326
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
8.2
7.6
16
20
I97.0
ICD-10 Finland
Postcardiotomy syndrome
18.7
7.6
11
6
WX870
NOMESCO Finland
Other postsurgical intensive care
18.7
7.6
11
6
1AB02, ,
NOMESCO Finland
12.1
7.6
13
11
JDB10
NOMESCO Finland
Percutaneous gastrostomy
7.3
7.5
17
24
74
HP
Initial installation of the atrial pacemaker
81.2
7.4
8
*
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
81.2
7.4
8
*
ZXA00
NOMESCO Finland
Right side
2.0
7.4
92
512
Q20.41
ICD-10 Finland
Double inlet right ventricle
+∞
7.3
7
*
7450A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Common truncus[TRUNCUS ARTERIOSUS COMMUNIS]
+∞
7.3
7
*
Q22.6
ICD-10 Finland
Hypoplastic right heart syndrome
+∞
7.3
7
*
FBJ00
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery
+∞
7.3
7
*
Q25.70
ICD-10 Finland
Aneurysm, congenital of pulmonary artery
+∞
7.3
7
*
FHE00
NOMESCO Finland
Transatrial repair of tetralogy of Fallot
+∞
7.3
7
*
5269
FHL
Other measure in this category
+∞
7.3
7
*
74669
ICD-8 Finland
Congenital anomalies of heart, Aliae maleformationes valvulae pulmonaris sive ventriculi dextri
+∞
7.3
7
*
FHB96
NOMESCO Finland
Other closure of congenital ventricular septal defect
+∞
7.3
7
*
Q20.4
ICD-10 Finland
Double inlet ventricle
+∞
7.3
7
*
7452C
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[PULMONARY ATRESIA AND VENTRICULAR SEPTAL DEFECT]
+∞
7.3
7
*
5504
FHL
Subclavian pulmonary anastomosis (Blalock)
+∞
7.3
7
*
7468X
ICD-9 Finland
Other congenital anomalies of heart, Other specified anomalies of heart[MUU SYDÄMEN EPÄMUODOSTUMA]
+∞
7.3
7
*
51
HP
Other heart surgery
+∞
7.3
7
*
FPK00
NOMESCO Finland
Implantation of electrocardiograph with loop recorder
30.5
7.2
9
*
73
HP
Initial pacemaker installation
30.5
7.2
9
*
Q25.3
ICD-10 Finland
Stenosis of aorta
30.5
7.2
9
*
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
20.4
7.2
10
5
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.9
7.2
21
56
L04AD02
ATC
tacrolimus; systemic
4.2
7.1
19
47
GD1LA
NOMESCO Finland
GD
12.3
7.1
12
10
C08DB01
ATC
diltiazem; oral
7.7
6.9
15
20
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
14.0
6.9
11
8
Q53.1
ICD-10 Finland
Undescended testicle, unilateral
6.8
6.9
16
24
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
9.5
6.8
13
14
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.8
6.8
34
127
FBE96
NOMESCO Finland
Other expansion or reconstruction of pulmonary artery
40.6
6.8
8
*
J45.1
ICD-10 Finland
Nonallergic asthma
2.2
6.7
56
267
Q21.20
ICD-10 Finland
Atrial septal defect of primum type
22.9
6.7
9
*
Q21.18
ICD-10 Finland
Other spedified atrial septal defect
22.9
6.7
9
*
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
22.9
6.7
9
*
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
22.9
6.7
9
*
WZC30
NOMESCO Finland
Teaching
2.1
6.7
65
330
FB1AD
NOMESCO Finland
CT examination of arteria pulmonalis
6.0
6.7
17
29
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
7.0
6.6
15
22
I35.0
ICD-10 Finland
Aortic (valve) stenosis
5.4
6.5
18
34
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
4.0
6.5
18
46
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
7.5
6.4
14
19
FB1BC
NOMESCO Finland
Extensive angiography of arteria pulmonalis
70.7
6.4
7
*
FMC96
NOMESCO Finland
Other operation on aortic valve for insufficiency
70.7
6.4
7
*
5401
FHL
Pacemaker installation, transvenous electrode
70.7
6.4
7
*
K80
ICPC
Cardiac arrhythmia NOS
3.0
6.4
28
97
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
14.5
6.4
10
7
B01AB04
ATC
dalteparin; parenteral
3.5
6.4
21
61
81
HP
Angiography of the heart and coronary arteries
6.1
6.3
16
27
AP1
HP
Catheterization of the left side of the heart
11.2
6.3
11
10
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
18.3
6.3
9
5
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
18.3
6.3
9
5
324, ,
NOMESCO Finland
18.3
6.3
9
5
5207
FHL
VSD closure
+∞
6.3
6
*
5233
FHL
Right ventricular bypass surgery (Fontan et al.)
+∞
6.3
6
*
Q21.4
ICD-10 Finland
Aortopulmonary septal defect
+∞
6.3
6
*
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
+∞
6.3
6
*
I37.8
ICD-10 Finland
Other pulmonary valve disorders
+∞
6.3
6
*
Q22.3
ICD-10 Finland
Other congenital malformations of pulmonary valve
+∞
6.3
6
*
7468B
ICD-9 Finland
Other congenital anomalies of heart, Other specified anomalies of heart[STENOSIS PULMONALIS INFUNDIBULARIS]
+∞
6.3
6
*
Q25.5
ICD-10 Finland
Atresia of pulmonary artery
+∞
6.3
6
*
7473A
ICD-9 Finland
Other congenital anomalies of circulatory system, Anomalies of pulmonary artery
+∞
6.3
6
*
7461A
ICD-9 Finland
Other congenital anomalies of heart, Tricuspid atresia and stenosis, congenital[VITIUM VALVULAE TRICUSPIDALIS CONGENITUM CUM ATRESI]
+∞
6.3
6
*
FBL96
NOMESCO Finland
Other connection to pulmonary artery from aorta
+∞
6.3
6
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.0
6.3
27
93
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.2
6.2
52
248
7470A
ICD-9 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
27.0
6.2
8
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.5
6.2
21
62
RS221, ,
NOMESCO Finland
3.5
6.2
21
62
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
6.2
38
158
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.6
6.2
36
146
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
2.8
6.1
31
117
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
2.7
6.1
32
123
M04AA01
ATC
allopurinol; systemic
2.8
6.1
29
106
KFH00
NOMESCO Finland
Operation for undescended or ectopic testis
6.1
6.0
15
25
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
5.7
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
241
182
24.50
276.21
5.8
4.4
166.06
186.73
ng/l
0.23
226
162
360
541
20.89
270.07
8.0
5.0
851.88
886.87
ng/l
0.09
348
445
216
573
5.85
81.67
5.4
6.9
32.39
30.54
s
3.99
216
568
297
1127
4.99
70.68
27.2
8.1
1.77
1.16
inr
9.03
68
327
197
539
5.36
70.50
6.5
3.6
2766.02
769.36
ng/l
2.25
171
335
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
71
86
9.45
55.75
14.1
22.8
0.29
0.36
u/ml
1.26
51
51
232
890
3.98
50.54
3.3
3.0
—
—
—
0
0
249
1026
3.83
48.35
9.5
7.5
72.23
88.69
%
20.10
249
1013
174
564
4.19
47.78
12.4
10.9
0.81
0.81
mmol/l
0.04
167
542
63
80
8.86
47.48
3.0
6.1
81.49
97.99
%
3.23
63
80
65
92
7.97
44.70
1.4
1.5
—
—
—
0
0
87
177
5.73
42.06
1.7
2.4
23.89
8.67
ug/l
3.04
79
158
140
489
3.58
33.12
4.2
2.9
22.80
22.86
%
0.02
130
451
291
1588
2.98
31.50
3.8
3.1
—
—
—
0
0
68
149
5.12
29.92
20.9
17.0
—
—
—
0
0
95
280
3.95
28.58
18.6
12.3
1.06
0.49
mmol/l
0.68
87
230
113
389
3.46
26.87
11.7
10.3
106.12
104.83
mmol/l
2.31
113
389
171
753
2.93
26.68
4.0
4.0
1.54
1.46
mg/l
0.09
123
541
181
843
2.79
25.18
4.6
3.0
78.93
30.47
ng/l
0.95
115
433
276
1619
2.56
23.58
10.3
7.7
22.02
19.42
umol/l
0.63
266
1522
327
2125
2.54
21.74
12.4
6.9
6.13
6.30
mmol/l
1.17
315
1968
186
938
2.56
21.45
3.3
3.3
3.39
2.67
mg/l
1.47
170
822
473
3805
5.08
19.99
28.5
13.2
139.32
139.52
mmol/l
1.23
473
3701
24
33
7.59
16.66
1.6
1.8
153.17
128.61
%
0.92
24
33
26
20
13.64
15.34
2.5
6.1
—
—
—
0
0
141
717
2.34
15.17
8.3
10.1
1.57
1.20
mmol/l
0.79
123
572
92
384
2.71
15.06
2.8
1.9
—
—
—
0
0
212
1280
2.13
14.88
8.3
7.6
35.89
37.31
g/l
2.51
204
1219
92
388
2.68
14.74
3.0
2.0
—
—
—
0
0
273
1822
2.09
14.59
16.8
11.4
1.21
1.22
mmol/l
3.68
259
1652
259
1706
2.07
14.22
20.6
11.7
1.20
1.23
mmol/l
7.35
250
1616
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
25
43
6.07
14.12
1.6
1.8
119.64
121.74
%
0.05
25
43
108
508
2.43
13.72
2.9
1.9
—
—
—
0
0
129
669
2.25
13.02
15.3
9.4
2.26
0.86
mmol/l
7.70
112
481
39
108
3.83
12.57
2.6
2.4
1.01
1.21
g/l
0.83
31
97
36
95
4.00
12.40
7.7
16.7
71.92
69.51
%
0.39
36
95
51
171
3.21
12.30
7.3
11.1
0.71
0.62
%
1.16
51
171
18
13
14.31
11.04
1.6
1.5
4770.17
2411.13
e6/l
—
12
8
17
11
15.94
10.89
1.6
1.5
100279.36
21535.00
e6/l
—
11
6
297
2179
1.89
10.73
10.1
9.0
2.98
3.09
%
0.31
288
2078
291
2128
1.87
10.55
11.1
10.8
0.00
0.00
e9/l
1.01
252
1646
305
2281
1.86
10.11
10.0
8.8
27.70
33.58
%
17.53
296
2188
299
2244
1.82
9.57
9.9
8.7
57.11
51.45
%
14.45
290
2154
358
2844
1.90
9.50
18.6
8.6
97.70
96.44
ml/min/173m2
0.38
300
2137
254
1862
1.74
8.39
4.1
3.3
93.62
75.85
ug/l
1.21
246
1760
40
146
2.89
8.34
2.4
2.2
—
—
—
0
0
132
800
1.88
8.29
3.4
2.4
412.65
367.28
u/l
0.16
127
772
31
99
3.27
8.09
1.9
1.9
—
—
—
0
0
320
2517
1.75
8.08
11.5
11.4
3.78
3.72
e9/l
0.23
299
2114
39
143
2.87
8.07
2.5
2.1
—
—
—
0
0
23
62
3.84
7.71
1.4
1.3
—
—
—
0
0
90
497
1.99
7.39
4.7
6.1
8.66
8.54
umol/l
0.03
85
410
494
4658
4.38
7.06
35.9
17.7
40.39
40.41
%
0.02
483
4463
494
4664
4.31
6.91
32.5
17.2
4.64
4.63
e12/l
0.14
489
4498
16
24
6.85
6.86
1.3
1.1
65.20
88.40
%
—
5
5
32
116
2.88
6.77
2.2
1.9
—
—
—
0
0
494
4668
4.26
6.76
34.0
17.4
136.04
136.22
g/l
0.08
494
4616
20
54
3.82
6.70
2.0
2.2
—
—
—
0
0
41
172
2.51
6.56
2.4
1.6
—
—
—
0
0
313
2529
1.63
6.39
10.2
6.5
95.17
101.82
u/l
1.07
305
2387
12
13
9.42
6.32
1.5
1.7
—
—
—
0
0
46
208
2.33
6.26
1.6
1.7
—
—
—
0
0
20
57
3.61
6.22
1.9
1.4
—
—
—
0
0
453
4072
2.13
6.21
23.4
11.6
24.48
22.43
mg/l
0.70
380
2918
27
94
2.98
6.14
2.1
2.0
—
—
—
0
0
27
94
2.98
6.14
2.5
4.0
—
—
—
0
0
24
79
3.14
6.00
1.3
1.2
1.50
3.58
u/ml
—
10
33
31
120
2.69
5.83
2.6
2.2
—
—
—
0
0
31
120
2.69
5.83
2.6
2.2
—
—
—
0
0
24
81
3.06
5.76
1.3
1.2
6.10
4.22
u/ml
—
10
37
23
78
3.04
5.48
1.2
1.1
—
—
—
0
0
41
188
2.29
5.42
3.8
3.0
65.77
79.40
ml/min/173m2
0.50
13
75
27
104
2.69
5.14
2.8
2.2
—
—
—
0
0
27
104
2.69
5.14
2.8
2.2
—
—
—
0
0
443
4016
1.86
4.95
13.3
9.4
27.18
28.77
u/l
0.93
433
3890
174
1296
1.52
4.61
4.5
4.1
—
—
—
0
0
33
148
2.32
4.61
6.8
7.3
24.89
24.60
mmol/l
0.25
33
143
39
188
2.16
4.60
2.5
2.1
110.80
93.63
u/ml
—
5
20
18
61
3.02
4.32
2.4
3.2
16.52
17.68
%
—
10
40
17
57
3.05
4.16
1.6
1.6
—
—
—
0
0
113
782
1.57
4.11
4.1
3.1
5.43
6.62
e6/l
0.36
101
689
38
191
2.07
4.05
2.5
2.0
—
—
—
0
0
45
241
1.95
4.03
5.4
3.6
4.80
4.85
pmol/l
0.07
40
220
22
87
2.60
4.02
1.7
1.6
—
—
—
0
0
150
1111
1.50
3.99
4.3
3.9
0.52
0.27
e6/l
0.74
118
824
28
128
2.26
3.77
15.0
11.7
295.50
402.82
iu/ml
—
6
22
24
109
2.26
3.31
1.2
1.5
—
—
—
0
0
10
24
4.23
3.21
1.5
1.2
—
—
—
0
0
132
995
1.44
3.13
3.2
3.3
2.37
2.38
mmol/l
0.51
122
903
14
51
2.80
3.01
1.7
1.6
—
—
—
0
0
123
926
1.43
2.92
3.6
2.8
49.35
57.53
u/l
1.99
118
862
97
699
1.48
2.89
2.9
3.6
2.91
1.95
e6/l
0.39
56
397
6
9
6.73
2.87
3.8
4.0
—
—
—
0
0
17
71
2.44
2.83
2.2
1.8
—
—
—
0
0
111
1451
0.70
2.81
1.5
1.6
0.91
2.67
u/ml
2.56
31
281
6
10
6.06
2.70
1.8
1.2
11.17
15.10
u/l
—
6
10
9
24
3.80
2.68
1.6
1.7
—
—
—
0
0
20
93
2.20
2.64
2.2
1.7
—
—
—
0
0
265
2287
1.34
2.64
4.8
3.9
14.50
566.00
e6/l
—
6
25
348
3793
0.73
2.59
4.0
3.8
—
—
—
0
0
18
82
2.24
2.50
5.2
4.4
56.44
52.65
%
0.46
18
82
15
63
2.42
2.48
1.4
1.4
—
—
—
0
0
37
222
1.72
2.38
1.6
1.7
—
—
—
0
0
12
46
2.65
2.37
2.5
1.3
—
—
—
0
0
19
91
2.13
2.36
2.5
1.8
—
—
—
0
0
39
240
1.68
2.30
3.6
2.6
—
—
—
0
0
41
259
1.63
2.20
7.3
5.6
—
—
—
0
0
24
419
0.55
2.18
1.1
1.1
—
—
—
0
0
8
25
3.23
2.10
8.3
8.2
—
—
—
0
0
16
76
2.14
2.04
2.9
2.0
—
—
—
0
0
9
32
2.84
2.01
1.2
1.7
—
—
—
0
0
9
32
2.84
2.01
1.2
1.7
—
—
—
0
0
9
32
2.84
2.01
1.2
1.7
—
—
—
0
0
54
376
1.49
1.93
1.5
2.4
2.41
2.43
mmol/l
0.55
45
321
5
141
0.35
1.91
1.0
4.2
405.60
364.58
e6/l
—
5
106
7
22
3.21
1.88
5.7
3.2
—
—
—
0
0
9
34
2.68
1.87
7.4
10.9
—
—
—
0
0
7
165
0.42
1.82
1.7
1.7
39.43
36.28
nmol/l
—
7
159
9
36
2.53
1.74
2.3
1.5
—
—
—
0
0
16
82
1.98
1.71
4.8
3.8
3.88
3.55
e9/l
0.22
16
82
0
47
0.00
1.71
0.0
1.3
—
—
—
0
0
91
712
1.34
1.70
3.1
3.4
0.98
0.57
e6/l
0.61
51
408
10
40
2.53
1.67
2.2
2.4
—
—
—
0
0
22
127
1.77
1.67
1.5
1.5
—
—
—
0
0
22
127
1.77
1.67
1.5
1.5
—
—
—
0
0
8
31
2.61
1.66
3.6
2.8
949.63
1055.94
u/ml
—
8
31
47
329
1.47
1.66
1.5
1.6
1065.79
1184.05
nmol/l
0.46
38
252
7
25
2.82
1.65
1.6
1.2
—
—
—
0
0
69
896
0.73
1.61
1.8
2.1
—
—
—
0
0
62
461
1.39
1.59
1.4
1.5
462.56
16184028.83
pmol/l
0.50
54
414
49
350
1.44
1.57
2.2
2.5
28.36
31.51
u/l
0.33
39
291
16
85
1.91
1.56
1.4
1.7
—
—
—
0
0
34
225
1.55
1.56
2.5
2.0
214.88
182.68
u/ml
0.29
24
111
25
386
0.63
1.46
3.0
2.2
10.52
12.25
nmol/l
0.50
25
357
21
125
1.71
1.46
1.3
1.2
—
—
—
0
0
5
16
3.15
1.44
1.0
1.4
1.33
1.46
g/l
—
5
16
299
2743
1.22
1.41
4.9
4.3
36.90
38.05
mmol/mol
1.58
283
2597
6
23
2.63
1.37
1.3
1.1
—
—
—
0
0
5
17
2.96
1.36
1.0
1.5
—
—
—
0
0
33
227
1.49
1.30
2.5
2.0
—
—
—
0
0
5
18
2.79
1.29
1.0
1.6
1.01
0.89
g/l
—
5
18
5
18
2.79
1.29
1.0
1.6
—
—
—
0
0
17
276
0.60
1.25
1.1
1.2
7.28
6.84
u/ml
0.05
12
206
79
970
0.78
1.23
1.9
2.3
—
—
—
0
0
7
145
0.48
1.22
1.0
4.0
430.86
424.80
mg/l
—
7
138
17
271
0.61
1.17
1.0
1.2
2.03
1.24
u/ml
0.19
11
193
13
222
0.57
1.17
1.3
1.9
—
—
—
0
0
21
134
1.59
1.16
1.1
1.1
—
—
—
0
0
7
30
2.35
1.12
6.0
6.7
—
—
—
0
0
7
30
2.35
1.12
7.7
6.7
—
—
—
0
0
7
138
0.50
1.11
1.0
4.0
3.76
3.43
mmol/l
—
7
130
21
137
1.56
1.07
1.1
1.1
—
—
—
0
0
16
98
1.65
1.04
1.8
1.9
—
—
—
0
0
17
106
1.62
1.04
2.3
1.9
3.06
5.29
iu/l
—
5
34
20
297
0.66
1.03
1.2
1.3
17.84
2.72
u/ml
1.18
15
215
14
221
0.62
0.95
1.0
1.4
—
—
—
0
0
6
28
2.16
0.91
1.2
1.8
—
965650.00
—
0
5
19
127
1.52
0.90
1.1
3.0
—
—
—
0
0
312
2938
1.16
0.89
4.4
3.7
15.37
14.52
pmol/l
6.57
290
2729
6
29
2.08
0.89
2.5
4.1
183.83
199.67
ug/l
—
6
29
6
29
2.08
0.89
6.2
3.0
107.17
105.86
mmol/l
—
6
29
65
781
0.81
0.86
4.4
3.1
1.02
1.02
kg/l
—
9
124
315
2976
1.16
0.84
3.9
3.3
1.29
1.25
mmol/l
0.43
297
2795
17
248
0.67
0.83
1.5
1.4
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
0
25
0.00
0.79
0.0
1.0
—
—
—
0
0
22
302
0.72
0.78
2.1
2.3
0.41
0.68
ug/l
2.44
12
157
20
279
0.71
0.78
3.8
3.5
30.15
31.09
%
0.16
13
200
0
28
0.00
0.76
0.0
2.2
—
—
—
0
0
14
91
1.55
0.76
1.6
1.7
—
—
—
0
0
5
24
2.09
0.74
2.0
1.3
79.40
70.33
umol/l
—
5
24
283
2670
1.14
0.73
6.5
4.3
7.93
8.58
mm/h
0.55
269
2482
11
68
1.63
0.72
1.0
1.0
160.27
163.22
g/l
0.21
11
68
5
27
1.86
0.68
1.8
1.6
—
—
—
0
0
112
1250
0.87
0.66
4.3
3.2
—
—
—
0
0
10
154
0.64
0.65
1.9
1.7
—
—
—
0
0
20
269
0.73
0.65
1.1
1.2
5.68
2.27
u/ml
0.54
14
198
74
642
1.18
0.62
4.4
3.9
20.54
35.47
mg/mmol
0.25
52
447
9
139
0.64
0.61
1.4
1.5
—
—
—
0
0
94
833
1.16
0.61
1.8
1.8
1.47
1.36
mmol/l
0.47
87
739
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
23
175
1.33
0.59
2.0
1.4
—
—
—
0
0
6
35
1.72
0.58
1.2
1.2
—
—
—
0
0
8
54
1.49
0.57
1.1
1.1
—
—
—
0
0
62
535
1.18
0.56
1.2
1.2
17.29
21.27
iu/ml
0.32
19
155
10
65
1.55
0.56
1.5
2.2
—
—
—
0
0
8
125
0.63
0.55
1.1
1.9
—
—
—
0
0
9
60
1.51
0.54
1.6
1.9
—
—
—
0
0
9
61
1.48
0.54
1.3
1.7
—
—
—
0
0
25
311
0.79
0.49
1.7
2.6
14809.14
3474.06
u/l
—
7
122
19
245
0.77
0.49
1.1
1.2
—
—
—
0
0
13
176
0.73
0.46
1.4
1.6
—
—
—
0
0
324
3128
1.10
0.46
4.2
3.5
4.34
4.60
mmol/l
4.45
310
2959
25
304
0.81
0.42
2.8
2.0
6.15
6.31
u/l
0.03
18
218
5
33
1.52
0.41
1.0
1.2
82.26
231.65
iu/ml
—
5
33
13
172
0.75
0.41
1.1
1.1
12.29
6.87
u/ml
—
8
108
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
19.47
—
0
16
354
3441
1.10
0.41
5.1
4.2
2.10
1.89
mu/l
2.20
336
3231
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.6
—
—
—
0
0
5
34
1.48
0.40
1.2
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
3.1
—
91.11
—
0
18
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
5
36
1.39
0.38
1.4
1.6
—
—
—
0
0
111
1030
1.10
0.36
3.9
4.1
6.30
8.38
mmol/l
5.49
103
945
33
384
0.85
0.36
1.5
1.5
—
—
—
0
0
11
145
0.75
0.35
1.0
1.0
21.18
19.30
mmol/l
2.20
11
145
6
45
1.34
0.34
4.5
5.6
—
—
—
0
0
6
46
1.31
0.33
1.5
3.4
25.83
25.08
ug/l
—
6
46
6
89
0.67
0.33
1.7
5.0
415.50
390.72
umol/l
—
6
81
32
369
0.86
0.32
1.4
1.5
—
—
—
0
0
7
53
1.33
0.31
1.1
4.7
—
—
—
0
0
7
53
1.33
0.31
1.1
4.7
—
—
—
0
0
7
54
1.30
0.30
1.1
1.2
81.57
75.46
%
—
7
54
13
102
1.28
0.30
1.4
1.4
211.57
328.06
ug/g
—
7
55
8
107
0.74
0.29
1.1
1.3
14.43
4.66
ug/l
—
8
97
33
289
1.15
0.28
1.7
1.2
—
—
—
0
0
59
539
1.11
0.27
1.4
1.5
—
—
—
0
0
306
2983
1.07
0.27
3.5
3.2
5.66
5.66
mmol/l
0.03
289
2749
5
73
0.68
0.26
1.4
1.2
—
—
—
0
0
5
75
0.66
0.26
1.2
1.4
—
—
—
0
0
36
402
0.89
0.25
2.9
3.4
28.58
21.88
%
0.84
12
143
320
3129
1.06
0.25
4.5
3.7
2.70
2.81
mmol/l
1.41
302
2940
317
3101
1.06
0.24
4.2
3.5
1.31
1.40
mmol/l
4.82
300
2921
11
136
0.80
0.23
1.1
1.1
—
—
—
0
0
21
181
1.17
0.23
1.3
1.3
—
—
—
0
0
5
41
1.22
0.22
1.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
72.70
—
0
11
0
11
0.00
0.21
0.0
1.2
—
9.06
—
0
11
158
1521
1.06
0.21
4.0
3.2
71.33
72.06
nmol/l
0.13
146
1422
6
48
1.25
0.20
1.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
2.9
—
—
—
0
0
93
972
0.95
0.16
1.7
1.7
88.99
95.89
pmol/l
0.95
49
494
8
72
1.11
0.16
1.1
1.2
—
—
—
0
0
40
431
0.92
0.16
1.5
1.9
—
—
—
0
0
6
76
0.79
0.15
4.3
5.9
2.93
1.94
ug/l
—
6
76
6
79
0.76
0.15
1.0
1.3
52.33
194.68
pmol/l
—
6
74
89
852
1.05
0.15
4.6
3.5
0.06
0.01
estimate
0.42
31
313
150
1544
0.96
0.14
1.7
1.9
—
—
—
0
0
248
2434
1.04
0.14
4.1
4.0
53.70
37.32
u/l
2.88
238
2343
55
520
1.06
0.13
1.2
1.2
15.14
6.57
u/ml
0.28
20
191
17
189
0.90
0.12
1.2
1.4
158.02
273.67
miu/ml
—
6
94
25
231
1.09
0.11
1.5
1.8
—
—
—
0
0
50
525
0.95
0.10
2.9
3.4
0.95
1.55
ug/l
4.28
44
481
5
44
1.14
0.10
1.8
1.1
—
—
—
0
0
174
1771
0.97
0.09
3.9
3.4
0.00
0.00
estimate
-0.00
32
307
5
62
0.80
0.08
1.8
2.1
0.21
0.12
nmol/l
—
5
51
35
333
1.05
0.07
1.2
1.3
83.86
172.24
iu/ml
0.99
12
117
177
1744
1.02
0.07
3.9
3.4
0.00
0.00
estimate
0.50
36
324
11
122
0.90
0.07
1.5
2.2
1.76
0.54
nmol/l
1.01
11
108
20
214
0.93
0.07
1.3
1.3
—
—
—
0
0
9
88
1.02
0.07
2.7
4.4
19.13
19.27
u/ml
—
9
88
173
1751
0.98
0.05
5.3
4.9
0.00
0.00
estimate
-0.00
34
323
18
190
0.95
0.04
1.6
1.4
—
—
—
0
0
18
190
0.95
0.04
1.6
1.4
—
—
—
0
0
18
189
0.95
0.03
1.6
1.4
—
—
—
0
0
18
189
0.95
0.03
1.6
1.4
—
—
—
0
0
15
157
0.95
0.01
1.1
1.1
—
9.58
—
0
6
13
126
1.03
0.00
1.1
2.0
—
—
—
0
0
15
154
0.97
0.00
1.8
1.8
18.42
3.19
mg/l
—
10
103
21
208
1.01
0.00
1.4
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
56
0.89
-0.00
1.0
1.1
—
—
—
0
0
7
78
0.90
-0.00
1.1
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
346.29
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
59
1.02
-0.00
4.7
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.3
—
3.73
—
0
7
5
49
1.02
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
—
—
0
0
54
540
1.00
-0.00
1.5
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
16.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONOTR_DEFEC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONOTR_DEFEC | 5.183 [3.58, 7.5] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.185 |
During the follow-up period (1.1.1998 — 31.12.2019), 107 out of 1995 females with Q17_CONOTR_DEFEC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONOTR_DEFEC | 5.139 [3.95, 6.69] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 145 out of 1886 males with Q17_CONOTR_DEFEC died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONOTR_DEFEC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.538% | 0.792% |
| 5 | 2.78% | 5.754% |
| 10 | 7.43% | 14.799% |
| 15 | 14.02% | 25.698% |
| 20 | 23.042% | 39.601% |
Relationships between endpoints
↥Index endpoint: Q17_CONOTR_DEFEC – Conotruncal defects
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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