info icon

Shock, not elsewhere classified

R18_SHOCK_NOT_ELSEW_CLASSIFIED

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 R57
  • Cause of death: ICD-10 R57

2 out of 7 registries used, show all original rules.

345

4. Check minimum number of events

None

345

5. Include endpoints

None

345

6. Filter based on genotype QC (FinnGen only)

345

Control definitions (FinnGen only)

Control exclude
R18_GENERAL_SYMPTOMS_SIGNS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
R[5-6]
Name in latin
Plaga non alibi classificata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 345 138 207
Unadjusted period prevalence (%) 0.07 0.05 0.09
Median age at first event (years) 65.25 61.81 67.54

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
302
Matched controls
3021
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R57.0
ICD-10 Finland
Cardiogenic shock
+∞
139.7
123
*
R57.9
ICD-10 Finland
Shock, unspecified
+∞
72.9
67
*
R57.1
ICD-10 Finland
Hypovolaemic shock
+∞
71.8
66
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
8.9
55.2
140
267
R57.8
ICD-10 Finland
Other shock
+∞
52.7
49
*
WX872
NOMESCO Finland
Intensive care
12.9
40.5
75
75
N17.9
ICD-10 Finland
Acute renal failure, unspecified
17.4
34.4
55
38
TPH07
NOMESCO Finland
Cathetrisation of artery
6.6
31.5
91
186
A41.9
ICD-10 Finland
Sepsis, unspecified
15.2
29.1
49
38
C03CA01
ATC
furosemide; systemic
4.0
27.7
156
632
R55
ICD-10 Finland
Syncope and collapse
22.7
26.4
38
19
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.9
25.9
80
174
R50.9
ICD-10 Finland
Fever, unspecified
12.4
25.1
46
43
ZXD05
NOMESCO Finland
Urgent procedure
3.8
24.0
139
559
AA1AD
NOMESCO Finland
CT of head and brain
4.1
22.6
105
346
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.4
22.0
93
279
TK800
NOMESCO Finland
Hemodialysis
19.3
21.9
33
19
R56.8
ICD-10 Finland
Other and unspecified convulsions
+∞
21.1
20
*
C07AB07
ATC
bisoprolol; oral
3.2
20.6
188
1025
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.0
20.1
59
118
WX892
NOMESCO Finland
Monitored bed care
6.8
19.9
52
89
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.2
19.8
87
268
WX704
NOMESCO Finland
Intubation
6.8
19.0
50
86
I50.9
ICD-10 Finland
Heart failure, unspecified
4.1
18.8
82
250
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.1
18.3
81
249
TPH04
NOMESCO Finland
Cathetrisation of vein
3.7
17.4
90
312
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
3.3
17.3
110
451
C03DA01
ATC
spironolactone; oral
4.5
17.2
66
176
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.2
16.9
112
469
WX408
NOMESCO Finland
General anesthesy, balanced
3.1
16.0
108
456
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.3
15.9
43
77
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.2
15.8
102
418
B01AA03
ATC
warfarin; systemic
3.2
15.7
99
398
I50.0
ICD-10 Finland
Congestive heart failure
5.0
15.6
53
124
C09AA05
ATC
ramipril; oral
2.9
14.9
111
498
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
5.2
14.5
46
100
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
5.1
14.4
47
105
N17.8
ICD-10 Finland
Other acute renal failure
23.7
14.4
20
9
JAH00
NOMESCO Finland
Laparotomy
10.5
14.0
27
28
L04AA06
ATC
mycophenolic acid; systemic
21.3
14.0
20
10
ZX120
NOMESCO Finland
Intravenous
4.7
13.8
49
120
R53
ICD-10 Finland
Malaise and fatigue
4.1
13.2
54
152
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
4.9
13.1
44
102
FXG00
NOMESCO Finland
Insertion and use of IABP
52.4
13.0
15
*
127
Kela drug reimbursment
Transplant complication
21.2
12.6
18
9
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
12.6
103
478
TK810
NOMESCO Finland
Hemofiltration
135.4
12.5
13
*
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
135.4
12.5
13
*
Z3226
NOMESCO Finland
Physiotherapist
3.1
12.2
76
297
I50.1
ICD-10 Finland
Left ventricular failure
5.3
12.1
37
77
WX882
NOMESCO Finland
High dependency care
9.6
12.0
24
27
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
48.7
12.0
14
*
J15.8
ICD-10 Finland
Other bacterial pneumonia
48.7
12.0
14
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
11.2
12.0
22
21
201
Kela drug reimbursment
Chronic cardiac insufficiency
4.9
12.0
40
92
Z3231
NOMESCO Finland
Registered nurse
2.6
11.9
104
501
ZXE40
NOMESCO Finland
More than seven and less than nine hours
10.7
11.7
22
22
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.0
11.5
48
137
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.9
11.2
47
135
A28
ICPC
Limited function/disability NOS
3.2
11.0
62
225
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.6
11.0
101
496
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
10.8
143
846
WW502
NOMESCO Finland
Autotransfusion
22.4
10.8
15
7
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
9.0
10.7
22
26
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
5.7
10.6
30
57
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
5.1
10.5
33
71
FXE00
NOMESCO Finland
Use of ECLA
113.8
10.5
11
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
7.1
10.4
25
38
WX302
NOMESCO Finland
Thoracal epidural anesthesy
5.5
10.3
30
59
R4110
NOMESCO Finland
Physiotherapy
2.5
10.2
96
474
ZXE30
NOMESCO Finland
More than five and less than seven hours
5.8
10.1
28
52
AN1
HP
Coronary angiography
3.1
9.9
58
214
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
7.2
9.8
23
34
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.5
9.8
86
409
205
Kela drug reimbursment
Chronic hypertension
2.3
9.7
115
637
Z2221
NOMESCO Finland
Medical doctor
2.4
9.6
93
465
FXF00
NOMESCO Finland
Decannulation after ECHLA or ECLA
103.1
9.5
10
*
I42.0
ICD-10 Finland
Dilated cardiomyopathy
8.7
9.2
19
23
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
12.0
9.2
16
14
XF400
NOMESCO Finland
ECG with 12 standard connections
2.8
9.1
65
273
C01BD01
ATC
amiodarone; systemic
7.8
9.1
20
27
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.8
9.1
38
109
1CX08
NOMESCO Finland
NA
37.9
9.1
11
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.2
9.0
49
170
J01FF01
ATC
clindamycin; systemic
2.4
8.9
87
433
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
9.0
8.9
18
21
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
9.9
8.9
17
18
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.0
8.9
54
205
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
5.4
8.9
26
52
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
4.3
8.8
32
81
I25.2
ICD-10 Finland
Old myocardial infarction
3.4
8.8
42
135
C10AA01
ATC
simvastatin; oral
2.1
8.8
148
949
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
3.3
8.7
44
148
H02AB06
ATC
prednisolone; systemic
2.1
8.6
139
873
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
8.5
116
677
ZXD00
NOMESCO Finland
Emergency procedure
5.8
8.5
23
42
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
4.5
8.5
29
69
C01DA14
ATC
isosorbide mononitrate; oral
2.5
8.4
71
327
E87.2
ICD-10 Finland
Acidosis
+∞
8.4
8
*
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
+∞
8.4
8
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.7
8.2
35
102
A02BC02
ATC
pantoprazole; systemic
2.0
8.2
188
1349
GBB00
NOMESCO Finland
Tracheostomy
12.2
8.2
14
12
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
12.2
8.2
14
12
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.2
8.1
42
143
TKC20
NOMESCO Finland
Catheterisation of bladder
3.3
8.1
40
132
JN4AD
NOMESCO Finland
Body CT examination
3.7
8.1
35
104
Z2446
NOMESCO Finland
Social worker
4.6
8.1
27
63
TQW11
NOMESCO Finland
Vacuum treatment of wound
13.5
7.9
13
10
TPX10
NOMESCO Finland
Implantation of vascular injection port
8.8
7.9
16
19
WX725
NOMESCO Finland
Noninvasive ventilation
5.3
7.9
23
46
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
15.5
7.8
12
8
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
3.9
7.7
31
86
R51.80
ICD-10 Finland
Headache
4.7
7.7
25
57
A11CC03
ATC
alfacalcidol; systemic
9.2
7.6
15
17
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.0
7.5
16
21
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.1
7.5
42
151
FXL00
NOMESCO Finland
Insertion and use of extra-, para- or intracorporeal VAD
82.0
7.4
8
*
R11
ICD-10 Finland
Nausea and vomiting
4.0
7.4
29
79
B03XA02
ATC
darbepoetin alfa; parenteral
9.7
7.4
14
15
Z94.1
ICD-10 Finland
Heart transplant status
+∞
7.3
7
*
I95.9
ICD-10 Finland
Hypotension, unspecified
16.2
7.3
11
7
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.7
7.3
31
91
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.3
7.3
73
365
R4130
NOMESCO Finland
Speech therapy
8.2
7.2
15
19
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.1
7.2
27
71
PD1BD
NOMESCO Finland
Extensive CT of abdominal aorta and branches
20.6
7.2
10
5
G04BE03
ATC
sildenafil; oral
10.4
7.1
13
13
I21.09
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
7.3
7.1
16
23
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
14.2
6.9
11
8
C09DX04
ATC
valsartan and sacubitril; oral
14.2
6.9
11
8
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.7
6.9
29
84
I20.90
ICD-10 Finland
Angina pectoris, unspecified
5.3
6.9
20
40
I21.01
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
6.4
6.9
17
28
PD5BD
NOMESCO Finland
Extensive CT of aorta
9.6
6.9
13
14
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
6.8
55
246
JN4BD
NOMESCO Finland
Extensive body CT
2.9
6.8
40
149
D64.9
ICD-10 Finland
Anaemia, unspecified
2.8
6.7
42
162
K72.9
ICD-10 Finland
Hepatic failure, unspecified
23.1
6.7
9
*
Z94.0
ICD-10 Finland
Kidney transplant status
23.1
6.7
9
*
C01AA05
ATC
digoxin; systemic
2.8
6.7
45
180
B01AB05
ATC
enoxaparin; parenteral
2.0
6.6
94
547
J01MA02
ATC
ciprofloxacin; systemic
1.9
6.6
119
759
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.9
6.6
26
72
WX730
NOMESCO Finland
Conventional respirator
7.7
6.5
14
19
R06.0
ICD-10 Finland
Dyspnoea
2.1
6.4
77
416
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.0
6.3
24
64
G72.8
ICD-10 Finland
Other specified myopathies
9.6
6.3
12
13
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
3.3
6.3
30
97
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
18.5
6.3
9
5
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
18.5
6.3
9
5
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.1
6.3
80
445
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.7
6.3
41
164
FQA10
NOMESCO Finland
Orthotopic transplantation of heart with bicaval anastomosis
+∞
6.3
6
*
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
27.3
6.3
8
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.6
6.3
17
32
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.4
6.2
28
87
J01MA14
ATC
moxifloxacin; systemic
3.1
6.2
32
110
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.0
6.1
23
61
Z49.1
ICD-10 Finland
Extracorporeal dialysis
8.9
6.1
12
14
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
5.4
6.1
17
33
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.9
6.1
14
21
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.0
6.1
85
489
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
5.0
6.0
18
38
I20.99
ICD-10 Finland
Angina pectoris, unspecified
3.3
6.0
29
95

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: R18_SHOCK_NOT_ELSEW_CLASSIFIED – Shock, not elsewhere classified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).