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Acidosis

DOID EFO Endpoint Browser PheWeb

E4_ACIDOSIS

lactic acidosis: Metabolic disease characterized by the accumulation of lactate in the body. It is caused by tissue hypoxia

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E87.2
  • Hospital discharge: ICD-9 — 2762
  • Hospital discharge: ICD-8 — 78869
  • Cause of death: ICD-10 — E87.2
  • Cause of death: ICD-9 — 2762
  • Cause of death: ICD-8 — 78869

2 out of 7 registries used, show all original rules.

782

4. Check minimum number of events

None

782

5. Include endpoints

None

782

6. Filter based on genotype QC (FinnGen only)

761

Control definitions (FinnGen only)

Control exclude
E4_METABOLIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E87
Name in latin
Acidosis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5856 2122 3700
Only index persons 5240 1915 3325
Unadjusted period prevalence (%)
Whole population 0.09 0.06 0.10
Only index persons 0.11 0.07 0.13
Median age at first event (years)
Whole population 65.37 68.63 63.47
Only index persons 65.67 68.69 63.92

-FinnGen-

Key figures

All Female Male
Number of individuals 761 267 494
Unadjusted period prevalence (%) 0.18 0.09 0.23
Median age at first event (years) 65.32 64.13 65.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
782
Matched controls
7820
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N17.9
ICD-10 Finland
Acute renal failure, unspecified
41.1
307.7
255
91
E87.2
ICD-10 Finland
Acidosis
4503599627370496.0
307.7
778
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
8.8
204.7
387
786
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
12.4
204.1
237
265
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
8.3
198.9
456
1128
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
60.5
186.6
105
20
103
Kela drug reimbursment
Diabetes, insulin-treated
7.7
182.2
484
1362
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
9.0
168.2
258
406
215
Kela drug reimbursment
Diabetes, non-insulin-treated
7.0
167.1
438
1197
A10AE04
ATC
insulin glargine; parenteral
9.3
164.2
240
356
A10BH01
ATC
sitagliptin; oral
8.6
156.2
245
393
A10BA02
ATC
metformin; oral
6.7
156.2
477
1482
T90
ICPC
Diabetes non-insulin dependent
6.2
145.3
416
1204
E87.6
ICD-10 Finland
Hypokalaemia
32.5
132.5
87
30
F10.25
ICD-10 Finland
Alcohol dependence continuous use
22.0
127.2
97
50
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
10.3
126.8
157
186
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
6.0
126.5
310
766
A10AB05
ATC
insulin aspart; parenteral
8.5
120.9
178
261
TK800
NOMESCO Finland
Hemodialysis
19.8
116.4
93
53
C03CA01
ATC
furosemide; systemic
5.0
110.8
431
1539
N17.8
ICD-10 Finland
Other acute renal failure
30.9
109.7
73
26
A10BB12
ATC
glimepiride; oral
7.5
102.8
169
278
E86
ICD-10 Finland
Volume depletion
148.0
98.7
103
8
E87.5
ICD-10 Finland
Hyperkalaemia
182.0
93.5
96
6
A10BH05
ATC
linagliptin; oral
8.5
85.4
119
161
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
8.2
82.2
118
165
N18.8
ICD-10 Finland
Other chronic renal failure
14.8
79.4
73
54
AA1AD
NOMESCO Finland
CT of head and brain
4.0
79.4
353
1323
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
25.6
77.8
55
23
WX872
NOMESCO Finland
Intensive care
7.6
74.6
115
174
T36
ICD-10 Finland
Poisoning by systemic antibiotics
9.2
73.8
95
116
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
14.0
71.7
68
53
A10AE05
ATC
insulin detemir; parenteral
7.2
71.5
115
182
TPH07
NOMESCO Finland
Cathetrisation of artery
5.0
71.2
182
446
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.6
70.4
205
558
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.9
69.4
184
464
F10.09
ICD-10 Finland
Alcohol intoxication UNS
12.5
68.9
70
61
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
14.8
68.9
63
46
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
15.7
68.9
61
42
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
19.9
68.8
54
29
SPAT1262
SPAT
Handing over of treatment supplies
4.1
68.5
255
831
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
6.5
67.7
122
217
F10.24
ICD-10 Finland
Alcohol depence active use
14.3
65.4
61
46
JN3AD
NOMESCO Finland
Abdominal CT examination
4.8
64.9
172
432
A41.9
ICD-10 Finland
Sepsis, unspecified
8.1
64.9
92
126
P15
ICPC
Chronic alcohol abuse
9.0
63.9
83
102
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
17.0
63.8
54
34
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
22.7
63.4
47
22
N19
ICD-10 Finland
Unspecified kidney failure
9.4
62.6
78
91
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
10.2
62.5
73
78
I50.9
ICD-10 Finland
Heart failure, unspecified
4.2
62.3
209
628
E11
ICD-10 Finland
Type 2 diabetes mellitus
4.0
61.6
225
718
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
8.4
61.4
84
110
N07BB01
ATC
disulfiram; oral
7.0
61.3
100
160
205
Kela drug reimbursment
Chronic hypertension
3.4
61.2
339
1420
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
9.1
59.7
76
91
C07AB07
ATC
bisoprolol; oral
3.4
59.3
518
2836
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
12.2
58.4
60
53
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
15.4
58.4
52
36
R11
ICD-10 Finland
Nausea and vomiting
5.2
56.3
129
285
WX892
NOMESCO Finland
Monitored bed care
5.3
56.1
127
278
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.6
55.3
151
386
WX730
NOMESCO Finland
Conventional respirator
15.9
54.9
48
32
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.2
54.7
176
509
I10
ICD-10 Finland
Essential (primary) hypertension
3.6
52.8
599
3726
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
3.9
52.6
185
569
A10AC01
ATC
insulin (human); parenteral
5.2
52.0
118
258
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.2
50.9
303
1299
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
50.7
478
2646
D64.9
ICD-10 Finland
Anaemia, unspecified
4.2
50.7
158
445
A28
ICPC
Limited function/disability NOS
3.6
50.5
212
733
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.7
50.5
197
649
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.1
50.2
344
1595
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
16.2
49.8
43
28
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
5.7
47.9
97
191
P16
ICPC
Acute alcohol abuse
11.1
47.7
52
50
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.4
47.7
103
215
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
15.2
47.1
42
29
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
7.2
46.2
72
109
F10.20
ICD-10 Finland
Alcohol dependence currently independent
9.5
46.0
56
63
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
5.7
45.3
90
174
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
43.4
312
1462
N05AH04
ATC
quetiapine; oral
3.3
42.5
195
706
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.5
42.3
113
281
Z49.1
ICD-10 Finland
Extracorporeal dialysis
13.5
42.0
40
31
C03DA01
ATC
spironolactone; oral
3.6
41.9
160
515
ZXD05
NOMESCO Finland
Urgent procedure
2.8
41.8
304
1428
M04AA01
ATC
allopurinol; systemic
3.4
41.5
183
646
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.8
41.5
299
1396
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
9.1
41.3
52
61
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
6.5
40.8
70
117
G72.8
ICD-10 Finland
Other specified myopathies
10.3
40.4
46
47
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
14.5
39.3
36
26
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
9.1
39.1
49
57
WX882
NOMESCO Finland
High dependency care
6.8
38.9
63
99
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
6.2
38.7
69
120
C08CA01
ATC
amlodipine; oral
2.6
38.4
386
2113
A11CC03
ATC
alfacalcidol; systemic
9.9
38.3
45
48
I50.0
ICD-10 Finland
Congestive heart failure
4.3
38.2
108
280
C10AA01
ATC
simvastatin; oral
2.6
38.0
405
2276
TKC20
NOMESCO Finland
Catheterisation of bladder
4.3
37.6
106
274
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.2
37.6
83
176
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.8
36.3
59
93
SPAT1254
SPAT
Administration of medicine
3.2
35.9
172
634
A10BJ06
ATC
semaglutide; parenteral
5.4
35.7
75
152
A10BK03
ATC
empagliflozin; oral
3.6
35.6
131
409
K92.0
ICD-10 Finland
Haematemesis
7.3
35.2
53
77
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
34.1
226
994
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.6
33.6
127
403
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.1
33.2
162
602
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
7.9
33.0
46
61
JAH00
NOMESCO Finland
Laparotomy
6.3
32.4
56
94
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.7
32.4
233
1066
TK810
NOMESCO Finland
Hemofiltration
36.0
32.2
41
12
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.6
32.1
116
357
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.5
32.0
122
389
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.1
31.9
70
147
R53
ICD-10 Finland
Malaise and fatigue
2.7
31.8
224
1013
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.6
31.5
117
366
E11.1
ICD-10 Finland
Type 2 diabetes mellitus, with ketoacidosis
41.0
31.5
39
10
N05CF01
ATC
zopiclone; oral
2.5
31.3
310
1646
L28
ICPC
Limited function/disability (L)
2.9
31.2
186
770
JN4AD
NOMESCO Finland
Body CT examination
3.3
31.1
138
483
N06AX11
ATC
mirtazapine; oral
2.4
30.7
309
1650
T89
ICPC
Diabetes insulin dependent
5.5
30.5
61
118
A10AE06
ATC
insulin degludec; parenteral
6.5
30.4
51
83
A10BK01
ATC
dapagliflozin; oral
4.0
30.4
95
264
B03XA02
ATC
darbepoetin alfa; parenteral
7.7
29.9
43
59
N05BA01
ATC
diazepam; systemic, rectal
3.1
29.4
147
551
A10BD07
ATC
metformin and sitagliptin; systemic
4.6
29.2
72
167
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.9
28.8
165
666
XCK10
NOMESCO Finland
Photography of fundus of eye
3.4
28.6
116
383
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
10.4
28.4
32
32
J96.0
ICD-10 Finland
Acute respiratory failure
9.8
28.1
33
35
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
8.1
27.9
38
49
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
5.7
27.8
53
98
M10.9
ICD-10 Finland
Gout, unspecified
3.7
27.4
94
278
C10AA05
ATC
atorvastatin; oral
2.3
27.4
372
2233
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
6.0
27.1
49
86
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
7.0
27.0
42
63
F05.9
ICD-10 Finland
Delirium, unspecified
8.0
27.0
37
48
B03BA03
ATC
hydroxocobalamin; parenteral
4.2
27.0
77
200
A06AD11
ATC
lactulose; oral
2.8
26.8
159
652
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.3
26.6
73
184
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.9
26.4
141
547
SPAT1125
SPAT
Stoma care and guidance
10.0
26.0
30
31
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
25.9
167
714
K70.0
ICD-10 Finland
Alcoholic fatty liver
22.8
25.9
37
17
A02BC02
ATC
pantoprazole; systemic
2.4
25.8
569
4128
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
6.3
25.7
44
73
A10AD05
ATC
insulin aspart; parenteral
9.0
25.6
32
37
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
25.2
289
1605
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
5.2
25.2
54
111
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
6.6
25.0
41
65
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.4
24.6
50
98
E66.00
ICD-10 Finland
Metabolic syndrome
4.3
24.5
66
164
N05CD07
ATC
temazepam; oral
2.9
24.3
134
527
N17.0
ICD-10 Finland
Acute renal failure with tubular necrosis
26.4
24.1
33
13
C09AA05
ATC
ramipril; oral
2.3
24.1
254
1358
A12BA01
ATC
potassium chloride; oral
4.5
23.9
60
141
C09AA02
ATC
enalapril; systemic
2.4
23.7
203
990
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
10.0
23.3
27
28
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
22.9
23.2
33
15
B01AA03
ATC
warfarin; systemic
2.4
23.0
197
959
R06.0
ICD-10 Finland
Dyspnoea
2.3
22.7
243
1301
N05BA04
ATC
oxazepam; oral
2.3
22.6
229
1199
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.3
22.6
230
1207
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.0
22.5
68
184
A10BG03
ATC
pioglitazone; oral
5.4
22.5
45
87
AN1
HP
Coronary angiography
2.9
22.3
114
429
A46
ICD-10 Finland
Erysipelas
2.6
22.2
155
686
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.4
22.1
87
281
E66.01
ICD-10 Finland
Obesity due to excess calories
3.7
22.1
75
220
N05BA02
ATC
chlordiazepoxide; systemic
5.1
22.1
47
96
K70.1
ICD-10 Finland
Alcoholic hepatitis
25.9
21.9
30
12
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
9.0
21.6
27
31
A10BB01
ATC
glibenclamide; oral
4.6
21.6
53
122
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
27.3
21.5
29
11
SPAT1229
SPAT
Assessment of need for aid
3.3
21.4
89
297
ZX120
NOMESCO Finland
Intravenous
3.0
21.2
100
360
S01.0
ICD-10 Finland
Open wound of scalp
3.1
21.0
98
350
N05AH03
ATC
olanzapine; systemic
3.7
20.8
69
199
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.3
20.8
56
139
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.4
20.6
174
838
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.0
20.6
45
94
A10AB04
ATC
insulin lispro; parenteral
5.4
20.5
41
79
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
5.1
20.4
44
91
N05AA02
ATC
levomepromazine; systemic
4.0
19.5
57
150
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
6.0
19.5
35
61
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
19.4
224
1225
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
4.1
19.3
54
138
A12AA04
ATC
calcium carbonate; oral
8.1
19.2
26
33
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.4
19.2
72
225
JFB00
NOMESCO Finland
Partial resection of small intestine
7.4
19.2
28
39
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.0
19.1
42
88
C07AB02
ATC
metoprolol; systemic
2.3
18.9
184
939
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.7
18.9
44
97
K56.7
ICD-10 Finland
Ileus, unspecified
6.7
18.9
30
46
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
6.7
18.9
30
46
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
18.7
151
711
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.1
18.7
85
299
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.2
18.5
79
268
S97
ICPC
Chronic ulcer skin
3.3
18.4
75
247
B01AC04
ATC
clopidogrel; oral
2.4
18.4
153
730
TQW11
NOMESCO Finland
Vacuum treatment of wound
5.8
18.3
34
61
N06AB04
ATC
citalopram; systemic
2.2
18.3
179
914
A10BJ02
ATC
liraglutide; parenteral
5.2
18.3
38
76
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.7
18.2
60
172
X59
ICD-10 Finland
Exposure to unspecified factor
2.3
18.1
173
874
E83.51
ICD-10 Finland
Hypocalcemia
53.8
18.0
21
*
S06.0
ICD-10 Finland
Concussion
2.7
18.0
104
417
A04
ICPC
Weakness/tiredness general
2.5
18.0
125
549
R50.9
ICD-10 Finland
Fever, unspecified
2.4
17.6
140
653
Y94.0
ICD-10 Finland
Accident at home
6.7
17.6
28
43
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
7.0
17.5
27
40
N02AX02
ATC
tramadol; systemic, rectal
1.9
17.5
368
2474
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
17.3
266
1607
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
6.4
17.3
29
47
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.3
17.2
163
819
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.3
17.2
45
109
177
Kela drug reimbursment
Insulin glargine 300 U / ml
6.6
17.2
28
44
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.5
17.1
123
548
A07AA09
ATC
vancomycin; oral
7.7
17.0
24
32
C02AC05
ATC
moxonidine; oral
3.7
16.8
54
152
N06AB10
ATC
escitalopram; oral
2.3
16.8
152
749
J01MA02
ATC
ciprofloxacin; systemic
1.9
16.7
326
2129
UJF32
NOMESCO Finland
Coloscopy
2.0
16.7
237
1389
Z72.1
ICD-10 Finland
Alcohol use
7.1
16.6
25
36
R33
ICD-10 Finland
Retention of urine
2.7
16.5
94
373
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.7
16.5
94
373
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
16.4
145
707
V03AA01, ,
ATC
5.6
16.3
31
57
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
16.3
125
573
Z3231
NOMESCO Finland
Registered nurse
2.0
16.3
231
1352
K29.2
ICD-10 Finland
Alcoholic gastritis
30.8
16.2
21
7
K70.4
ICD-10 Finland
Alcoholic hepatic failure
30.8
16.2
21
7
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
17.2
16.2
25
15
SPAT1231
SPAT
Assessment of adjustments needed in living environment
5.7
16.1
30
54
N06AX16
ATC
venlafaxine; oral
2.5
16.0
115
511
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.1
16.0
69
235
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
4.0
15.9
46
120
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
2.9
15.9
78
286
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.9
15.9
47
125
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
14.1
15.6
26
19
I95.9
ICD-10 Finland
Hypotension, unspecified
6.4
15.6
26
42
J01DB01
ATC
cefalexin; oral
2.1
15.5
634
5217
K85
ICD-10 Finland
Acute pancreatitis
5.9
15.5
28
49
UJD02
NOMESCO Finland
Gastroscopy
3.5
15.5
55
166
K92.1
ICD-10 Finland
Melaena
3.2
15.5
62
202
SPAT1216
SPAT
Assessment of functional ability
2.2
15.5
147
738
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.9
15.4
244
1478
T74.1
ICD-10 Finland
Physical abuse
7.2
15.3
23
33
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.4
15.2
114
516
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.3
15.1
60
194
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.0
15.1
71
254
I21.41
ICD-10 Finland
Acute subendocardial infarction stenosed coronary artery
3.6
14.9
50
145
SPAT1172
SPAT
Guidance concerning hydration
6.9
14.9
23
34
N30.0
ICD-10 Finland
Acute cystitis
2.5
14.9
107
475
R41.0
ICD-10 Finland
Disorientation, unspecified
4.5
14.9
37
86
WX704
NOMESCO Finland
Intubation
3.0
14.9
71
256
E16.19
ICD-10 Finland
Other specified hypoglycaemia
32.4
14.9
19
6
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
6.3
14.7
25
41
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
5.8
14.7
27
48
W19
ICD-10 Finland
Unspecified fall
2.6
14.7
95
402
C01DA14
ATC
isosorbide mononitrate; oral
2.3
14.6
128
620
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.9
14.6
74
276
N05AX08
ATC
risperidone; systemic
2.7
14.5
83
330
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.5
14.5
95
404
SPAT1234
SPAT
Support of social functional capacity
3.4
14.5
54
168
J01MA12
ATC
levofloxacin; systemic
2.1
14.4
171
934
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
10.7
14.3
27
26
R40.2
ICD-10 Finland
Coma, unspecified
13.7
14.3
24
18
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
5.4
14.3
28
53
K08.3
ICD-10 Finland
Retained dental root
2.7
14.2
79
309
A41.8
ICD-10 Finland
Other specified sepsis
5.1
14.1
30
61
A09AA02
ATC
multienzymes (lipase, protease etc.); oral
5.1
14.1
30
61
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
4.8
14.1
32
69
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
3.6
14.1
48
141
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
6.2
13.9
24
40
SPAT1167
SPAT
Insertion of urinary catheter
4.2
13.9
37
91
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.6
13.8
84
344
B01AB05
ATC
enoxaparin; parenteral
1.9
13.8
258
1640
OAB50, ,
SPAT
3.1
13.7
60
206
I95.1
ICD-10 Finland
Orthostatic hypotension
3.9
13.7
41
110
D10
ICPC
Vomiting
3.6
13.6
46
134
N02AA05
ATC
oxycodone; systemic
2.0
13.6
163
891
B01AB10
ATC
tinzaparin; parenteral
2.4
13.3
95
420
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.0
13.3
190
1105
H02AB09
ATC
hydrocortisone; systemic
5.2
13.2
27
53
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
12.4
13.2
23
19
N03AG01
ATC
valproic acid; systemic, rectal
3.1
13.1
58
200
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
5.6
13.1
25
46
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
5.6
13.1
25
46
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.9
13.0
38
100
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
3.9
13.0
38
100
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.7
13.0
24
43
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
5.0
12.7
27
55
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.6
12.7
30
67
C09CA01
ATC
losartan; oral
1.9
12.7
222
1377
N06AA12
ATC
doxepin; systemic
3.1
12.6
54
183
S76
ICPC
Skin infection other
3.1
12.6
54
183
K85.2
ICD-10 Finland
Alcohol-induced acute pancreatitis
17.7
12.6
19
11
207
Kela drug reimbursment
Chronic arrhythmias
2.0
12.5
147
796
127
Kela drug reimbursment
Transplant complication
6.3
12.5
21
34
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
12.5
95
432
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
20.4
12.5
18
9
N06AX03
ATC
mianserin; oral
3.2
12.5
51
168
H04AA01
ATC
glucagon; nasal, parenteral
5.7
12.5
23
41
UKC02
NOMESCO Finland
Cystoscopy
2.0
12.4
155
859
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.5
12.4
43
128
SPAT1301
SPAT
No procedures
1.8
12.3
250
1619
SPAT1263
SPAT
Sampling
1.7
12.3
316
2191
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.4
12.3
89
396
B81
ICPC
Anaemia vit B12/folate deficiency
3.6
12.3
40
114
C03AA03
ATC
hydrochlorothiazide; oral
2.5
12.2
82
352
N03AX16
ATC
[U] pregabalin
1.9
12.2
180
1054
K55.0
ICD-10 Finland
Acute vascular disorders of intestine
16.2
12.2
19
12
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.2
12.2
49
160
J01FF01
ATC
clindamycin; systemic
1.8
12.1
216
1344
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.9
12.1
199
1207
V03AE01
ATC
polystyrene sulfonate; oral
9.5
12.0
24
26
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
10.3
12.0
23
23
N02BE01
ATC
paracetamol; systemic, rectal
2.2
12.0
684
5955
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.9
12.0
35
92
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.1
12.0
121
618
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
4.9
12.0
26
54
Z2446
NOMESCO Finland
Social worker
2.7
11.9
65
252
A02BC01
ATC
omeprazole; systemic
1.8
11.8
212
1321
A10BJ05
ATC
dulaglutide; parenteral
5.0
11.7
25
51
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.0
11.7
149
829
F10.23
ICD-10 Finland
Alcohol dependence currently abstinent but using aversion-inducing or inhibitory medication
30.5
11.7
15
5
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
4.0
11.7
33
85
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.9
11.6
56
203
J01MA14
ATC
moxifloxacin; systemic
2.4
11.6
83
367
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
8.8
11.6
24
28
I25.2
ICD-10 Finland
Old myocardial infarction
2.7
11.6
63
244
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.5
11.5
78
336
R55
ICD-10 Finland
Syncope and collapse
2.3
11.4
95
449
Z02.7
ICD-10 Finland
Issue of medical certificate
2.7
11.4
64
252
F34.1
ICD-10 Finland
Dysthymia
3.7
11.3
36
101
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.8
11.2
25
53
L04AX01
ATC
azathioprine; systemic
3.3
11.2
42
131
J96.1
ICD-10 Finland
Chronic respiratory failure
4.0
11.2
32
83
T68
ICD-10 Finland
Hypothermia
12.9
11.2
19
15
C08CA13
ATC
lercanidipine; oral
2.1
11.2
123
649
F10.03
ICD-10 Finland
Alcohol-related acute intoxication with delirium
20.4
11.2
16
8
Z3226
NOMESCO Finland
Physiotherapist
2.0
11.1
143
798
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.5
11.1
70
292
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.1
11.1
48
164
N05AF03
ATC
chlorprothixene; systemic
4.5
11.1
27
62
NHQ40
NOMESCO Finland
Amputation of toe
5.8
11.0
20
35
EBA00
NOMESCO Finland
Extraction of tooth
1.7
11.0
272
1852
R60.0
ICD-10 Finland
Localized oedema
2.2
11.0
102
504
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.4
10.9
40
123
K91.2
ICD-10 Finland
Postsurgical malabsorption, not elsewhere classified
44.0
10.9
13
*
R42
ICD-10 Finland
Dizziness and giddiness
1.9
10.9
170
1010
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
15.8
10.9
17
11
XF600
NOMESCO Finland
Bloodpressure measurement
2.8
10.8
57
217
R00.1
ICD-10 Finland
Bradycardia, unspecified
3.4
10.8
39
119
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
18.1
10.8
16
9
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
10.7
121
645
NFJ54
NOMESCO Finland
Internal fixation of fracture of upper femur with intramedullary nail
5.4
10.6
21
40
SPAT1252
SPAT
Overall medication plan or its review
2.5
10.6
68
286
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
5.1
10.6
22
44
SPAT1249
SPAT
Treatment-related counselling outside office
1.7
10.6
297
2090
H02AB06
ATC
prednisolone; systemic
1.7
10.5
361
2673
N06AB03
ATC
fluoxetine; oral
2.2
10.5
96
471
Z09.4
ICD-10 Finland
Follow-up examination after treatment of fracture
3.0
10.5
48
169
C07AG02
ATC
carvedilol; oral
2.7
10.4
56
216
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
2.7
10.4
57
222
P76
ICPC
Depressive disorder
3.0
10.4
45
154
SPAT1240
SPAT
Therapeutic discussion
2.4
10.3
71
308
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
10.8
10.3
19
18
A10AB01
ATC
insulin (human); parenteral
3.7
10.3
33
93
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.5
10.2
66
278
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.4
10.2
37
113
OAB43, ,
SPAT
0.3
10.2
29
885
E66.9
ICD-10 Finland
Obesity, unspecified
3.6
10.1
33
94
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
4.4
10.1
25
58
160
Kela drug reimbursment
exenatide
4.4
10.1
25
58
N03AF01
ATC
carbamazepine; oral, rectal
2.8
10.1
51
190
J01EA01
ATC
trimethoprim; systemic
1.8
10.1
170
1034
C09BA02
ATC
enalapril and diuretics; systemic
2.4
10.0
73
325
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.1
10.0
27
67
5CM18, ,
NOMESCO Finland
14.8
10.0
16
11
E14.1
ICD-10 Finland
Unspecified diabetes mellitus, with ketoacidosis
40.6
10.0
12
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
10.0
94
467
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
9.9
138
790
R31
ICD-10 Finland
Unspecified haematuria
2.1
9.9
102
525
L89
ICD-10 Finland
Decubitus ulcer and pressure area
5.0
9.8
21
43
3025
Kela drug reimbursment
Calcium carbonate
20.3
9.8
14
7
E16.0
ICD-10 Finland
Drug-induced hypoglycaemia without coma
20.3
9.8
14
7
N06AA09
ATC
amitriptyline; systemic
2.3
9.8
76
348
I50.1
ICD-10 Finland
Left ventricular failure
2.7
9.8
52
199
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
9.8
203
1311
SPAT1265
SPAT
Breathalyser
7.5
9.7
22
30
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.3
9.7
74
336
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.8
9.7
50
188
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.3
9.7
25
60
S42.2
ICD-10 Finland
Fracture of upper end of humerus
3.0
9.7
43
149
E66.8
ICD-10 Finland
Other obesity
3.4
9.7
35
107
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.5
9.6
23
52
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.8
9.6
48
178
SPAT1279
SPAT
Preparation of immediate hospitalisation
9.2
9.6
19
21
Z49.0
ICD-10 Finland
Preparatory care for dialysis
10.2
9.6
18
18
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
3.3
9.5
35
108
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
15.3
9.5
15
10
SPAT1211
SPAT
Application of soft bandage
2.3
9.5
78
366
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
3.0
9.5
43
151
R4110
NOMESCO Finland
Physiotherapy
1.7
9.5
201
1305
T51.0
ICD-10 Finland
Toxic effect: Ethanol
17.8
9.4
14
8
Z94.0
ICD-10 Finland
Kidney transplant status
8.2
9.4
20
25
S82.6
ICD-10 Finland
Fracture of lateral malleolus
2.6
9.3
53
210
B01AF02
ATC
apixaban; oral
2.0
9.3
105
558
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
3.2
9.3
36
115
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
9.3
337
2508
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
7.4
9.3
21
29
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
4.0
9.2
26
67
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.2
9.2
76
358
EBA30
NOMESCO Finland
Extraction of root of tooth
2.5
9.2
57
236
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
7.9
9.2
20
26
SPAT1054
SPAT
Examination of peripheral nervous system
4.4
9.2
23
54
XG466
NOMESCO Finland
Sleep oxymetry
3.3
9.1
34
106
K07
ICPC
Swollen ankles/oedema
2.9
9.1
44
160
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
4.1
9.1
25
63
K77
ICPC
Heart failure
4.1
9.1
25
63
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.9
9.1
42
149
H36.01
ICD-10 Finland
Diabetic maculopathy
7.2
9.1
21
30
E13.8
ICD-10 Finland
Other specified diabetes mellitus, with unspecified complications
37.1
9.0
11
*
W00
ICD-10 Finland
Fall on same level involving ice and snow
2.1
9.0
87
437
SPAT1247
SPAT
Outpatient detoxication and monitoring
24.3
8.9
12
5
Z93.2
ICD-10 Finland
Ileostomy status
24.3
8.9
12
5
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.5
8.9
55
227
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
8.1
8.9
19
24
N30.9
ICD-10 Finland
Cystitis, unspecified
2.8
8.9
45
168
F43.00
ICD-10 Finland
Acute stress reaction mild
5.0
8.9
19
39
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.3
8.8
66
298
P29
ICPC
Psychological sympt/compl other
2.8
8.7
43
158
UJG02
NOMESCO Finland
Proctoscopy
3.9
8.7
25
65
KH1AD
NOMESCO Finland
CT of urinary organs
3.1
8.7
37
125
IAB10
NOMESCO Finland
Psychiatric consultation concerning substance abuse
50.6
8.7
10
*
E13.1
ICD-10 Finland
Other specified diabetes mellitus, with ketoacidosis
50.6
8.7
10
*
SPAT1255
SPAT
Intravenous administration of medicine
2.4
8.6
60
262
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
3.7
8.6
27
75
JFF13
NOMESCO Finland
Terminal enterostomy
16.5
8.6
13
8
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.6
8.6
50
201
NHJ10
NOMESCO Finland
Internal fixation of fracture of ankle using wire, rod, cerclage or pin
2.8
8.5
41
149
WX725
NOMESCO Finland
Noninvasive ventilation
2.7
8.5
46
178
SPAT1104
SPAT
Monitoring of emergency patient
2.4
8.5
60
264
C10AC01
ATC
colestyramine; oral
3.6
8.5
27
76
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.9
8.4
40
144
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
4.4
8.4
21
49
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.5
8.4
28
81
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
3.5
8.4
29
86
E000001, ,
ATC
1.8
8.4
141
853
L04AA06
ATC
mycophenolic acid; systemic
4.7
8.4
19
41
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
4.7
8.4
19
41
R18
ICD-10 Finland
Ascites
4.1
8.4
23
58
L04AD02
ATC
tacrolimus; systemic
10.9
8.3
15
14
A10BH02
ATC
vildagliptin; oral
4.2
8.3
22
54
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
9.6
8.3
16
17
F20.9
ICD-10 Finland
Schizophrenia, unspecified
3.9
8.3
24
63
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.8
8.3
127
747
ZY010
NOMESCO Finland
Hospital outpatient
2.8
8.2
40
146
S72.1
ICD-10 Finland
Pertrochanteric fracture
3.8
8.2
25
68
WX722
NOMESCO Finland
PEEP
2.6
8.2
49
199
H36.00
ICD-10 Finland
Diabetic background retinopathy
6.6
8.2
20
31
P01AB01
ATC
metronidazole; oral, rectal
1.6
8.2
264
1895
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.3
8.2
64
294
K90
ICPC
Stroke/cerebrovascular accident
3.6
8.2
26
73
I20.09
ICD-10 Finland
Unstable angina
2.6
8.1
46
182
NF1AA
NOMESCO Finland
Hip X-ray examination
2.1
8.1
77
383
KA3EB
NOMESCO Finland
Antegrade pyelography
17.4
8.1
12
7
F51.0
ICD-10 Finland
Nonorganic insomnia
2.0
8.1
99
541
S18
ICPC
Laceration/cut
1.5
8.1
350
2688
SPAT1100
SPAT
Long-term monitoring of blood pressure
2.4
8.1
57
251
F10.73
ICD-10 Finland
Residual or late-onset psychosis caused by alcohol dementia
22.3
8.0
11
5
C09AA03
ATC
lisinopril; oral
2.7
8.0
43
166
A10BG02
ATC
rosiglitazone; oral
4.3
8.0
20
47
P99
ICPC
Psychological disorders other
3.8
8.0
24
65
SPAT1260
SPAT
Consultation of another employee
1.8
7.9
135
819
FN1BT
NOMESCO Finland
Extensive endovascular dilatation of coronary (PTCA) arteries
4.0
7.9
22
56
WW500
NOMESCO Finland
Blood transfusion
2.8
7.9
38
138
N03AX14
ATC
levetiracetam; systemic
3.7
7.9
25
70
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
7.9
7.9
17
22
Y04.9
ICD-10 Finland
Assault by bodily force by unknown person
7.9
7.9
17
22
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
6.2
7.9
20
33
N06AB06
ATC
sertraline; oral
2.1
7.8
74
368
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.7
7.8
42
162
M10.0
ICD-10 Finland
Idiopathic gout
2.9
7.8
36
128
TJF80
NOMESCO Finland
Ostomy education
6.5
7.7
19
30
S70.0
ICD-10 Finland
Contusion of hip
2.9
7.7
35
123
V03AE02
ATC
sevelamer; oral
15.2
7.7
12
8
A10AD01
ATC
insulin (human); parenteral
4.4
7.7
19
44
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
7.7
163
1051
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
7.7
133
811
WZC00
NOMESCO Finland
Treatment plan or consultation
1.6
7.7
253
1822
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.1
7.7
31
102
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.8
7.6
37
135
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.6
7.6
43
170
N05BE01
ATC
buspirone; oral
3.2
7.6
30
97
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.8
7.6
111
642
ZXH04
NOMESCO Finland
Procedure performed in other inpatient unit
12.0
7.6
13
11
E83.50
ICD-10 Finland
Hypercalcemia
25.3
7.6
10
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.5
7.6
26
77
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.9
7.6
36
130
SPAT1227
SPAT
Substance abuse rehabilitation
10.2
7.6
14
14
C07AA05
ATC
propranolol; systemic
1.8
7.5
130
792
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
4.0
7.5
21
54
SPAT1307
SPAT
Psychosocial counselling and guidance
2.9
7.5
34
120
K20
ICD-10 Finland
Oesophagitis
4.5
7.5
18
41
K65.0
ICD-10 Finland
Acute peritonitis
6.6
7.4
18
28
L76
ICPC
Fracture: other
3.3
7.4
27
83
XF402
NOMESCO Finland
ECG with work load test
2.0
7.4
80
418
SPAT1251
SPAT
Organisation of medication
3.0
7.4
33
115
K78
ICPC
Atrial fibrillation/flutter
2.2
7.4
66
321
S92.3
ICD-10 Finland
Fracture of metatarsal bone
3.1
7.4
30
99
137
Kela drug reimbursment
Uraemia requiring dialysis
8.5
7.3
15
18
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.1
7.3
66
322
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
11.0
7.3
13
12
H3601, E113,
ICD-10 Finland
4.2
7.3
19
46
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
9.5
7.3
14
15
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
+∞
7.3
7
*
N17
ICD-10 Finland
Acute renal failure
+∞
7.3
7
*
C09AA04
ATC
perindopril; oral
2.5
7.3
44
180
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.4
7.3
51
224
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.3
7.2
55
250
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.0
7.2
32
111
R03BB04
ATC
tiotropium bromide; inhalant
1.9
7.2
89
487
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
7.2
196
1345
K59.1
ICD-10 Finland
Functional diarrhoea
2.5
7.2
43
175
B82
ICPC
Anaemia other/unspecified
3.3
7.2
27
85
Z72.0
ICD-10 Finland
Tobacco use
3.5
7.2
24
70
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
30.3
7.2
9
*
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.3
7.1
51
226
R02
ICPC
Shortness of breath/dyspnoea
1.9
7.1
95
534
L03.9
ICD-10 Finland
Cellulitis, unspecified
3.8
7.1
21
56
B80
ICPC
Iron deficiency anaemia
4.1
7.1
19
47
AN4
HP
Balloon angioplasty and drug eluding stent
3.1
7.1
29
96
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.1
7.1
29
96
R51.80
ICD-10 Finland
Headache
1.9
7.1
96
542
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
3.5
7.0
24
71
XFP96
NOMESCO Finland
Other intraoperative electrophysiological investigation in arhythmia or disturbance of impulse propagation
3.9
7.0
20
52
SPAT1310
SPAT
Counselling related to known health issue
1.6
7.0
228
1631
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.0
7.0
73
377
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
4.4
7.0
17
39
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.7
7.0
140
889
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.4
6.9
46
197
N05BA06
ATC
lorazepam; systemic, sublingual
2.4
6.9
45
191
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
13.9
6.9
11
8
V03AE03
ATC
lanthanum carbonate; oral
13.9
6.9
11
8
F10.41
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol with seizures
13.9
6.9
11
8
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.5
6.9
23
67
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
2.6
6.9
40
161
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
6.8
360
2848
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
3.8
6.8
20
53
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
3.3
6.7
25
78
Z29
ICPC
Social problem NOS
3.9
6.7
19
49
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
3.9
6.7
19
49
K86.1
ICD-10 Finland
Other chronic pancreatitis
7.3
6.7
15
21
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
7.3
6.7
15
21
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.7
6.7
36
139
SPAT1245
SPAT
Provision of support and information to patient’s family members
2.6
6.7
38
151
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
22.7
6.7
9
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
6.7
81
441
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.1
6.7
27
89
A10AB06
ATC
insulin glulisine; parenteral
6.5
6.7
16
25
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.3
6.7
51
233
E10
ICD-10 Finland
Type 1 diabetes mellitus
5.6
6.6
18
33
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
5.6
6.6
18
33
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
3.6
6.6
21
59
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
3.6
6.6
21
59
196
Kela drug reimbursment
Paricalcitol and cinacalcet
12.4
6.6
11
9
N05CF02
ATC
zolpidem; oral
1.7
6.6
121
749
F41.09
ICD-10 Finland
UNS Panic Syndrome
3.9
6.6
19
50
Z93.3
ICD-10 Finland
Colostomy status
10.1
6.5
12
12
T81.2
ICD-10 Finland
Accidental puncture and laceration during a procedure, not elsewhere classified
10.1
6.5
12
12
F60.9
ICD-10 Finland
Personality disorder, unspecified
6.9
6.5
15
22
A10AA02, ,
ATC
3.1
6.5
26
85
I20.00
ICD-10 Finland
Unstable angina
3.1
6.5
26
85
SPAT1070
SPAT
Doppler ultrasound examination of blood flow in arteries of lower extremity
3.7
6.5
20
55
A10BX07
ATC
[U] liraglutide
5.4
6.5
18
34
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.4
6.5
45
197
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
6.5
241
1771
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
3.6
6.5
21
60
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
6.5
255
1897
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.1
6.5
58
283
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
70.4
6.4
7
*
Y91.1
ICD-10 Finland
Moderate alcohol intoxication
70.4
6.4
7
*
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
3.8
6.4
19
51
S91.1
ICD-10 Finland
Open wound of toe(s) without damage to nail
4.1
6.4
17
42
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
4.1
6.4
17
42
R5110, ,
SPAT
2.2
6.4
50
231
K99
ICPC
Cardiovascular disease other
3.2
6.4
25
81
N18.0
ICD-10 Finland
End-stage renal disease
6.6
6.4
15
23
F10.01
ICD-10 Finland
Alcohol-related acute intoxication with permanent or other somatic damage
6.6
6.4
15
23
J96.9
ICD-10 Finland
Respiratory failure, unspecified
8.2
6.3
13
16
S82.8
ICD-10 Finland
Fractures of other parts of lower leg
2.8
6.3
31
114
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
6.0
6.3
16
27
P01
ICPC
Feeling anxious/nervous/tense
2.2
6.3
55
265
R52.2
ICD-10 Finland
Other chronic pain
2.9
6.3
29
103
KBJ10
NOMESCO Finland
Cutaneous ureteroenterostomy
11.1
6.3
11
10
F10.05
ICD-10 Finland
Alcohol-related acute intoxication with coma
18.2
6.3
9
5
WX402
NOMESCO Finland
General anaesthesia
1.6
6.3
141
921
Z2445
NOMESCO Finland
Psychologist
2.8
6.2
31
115
WVA20
NOMESCO Finland
Medicine administration
3.1
6.2
25
82
C08CA02
ATC
felodipine; oral
1.9
6.2
74
400
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
26.9
6.2
8
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.3
6.2
45
201
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
6.2
135
875
S22.3
ICD-10 Finland
Fracture of rib
2.0
6.2
66
344
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
2.3
6.2
44
195
Z95.5
ICD-10 Finland
Presence of coronary angioplasty implant and graft
2.7
6.1
31
116
TPH05
NOMESCO Finland
Open cannulation of peripheral vein
7.8
6.1
13
17
JN4BD
NOMESCO Finland
Extensive body CT
1.8
6.1
89
514
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.2
6.1
53
255
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.6
6.1
33
128
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
8.7
6.1
12
14
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.4
6.1
39
165
R4190
NOMESCO Finland
Nutritional therapy
2.7
6.1
31
117
F10.3
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state
10.1
6.0
11
11
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
2.8
6.0
29
106
K25.9
ICD-10 Finland
Gastric ulcer, Unspecified as acute or chronic, without haemorrhage or perforation
3.9
6.0
17
44
N05AB01
ATC
dixyrazine; systemic
3.9
6.0
17
44

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
337
484
11.48
244.23
11.4
6.5
12.45
9.43
mmol/l
8.28
322
464
387
724
9.60
222.96
10.3
5.3
1.09
1.03
mmol/l
1.64
364
667
390
906
7.59
177.74
5.7
3.5
0.76
0.83
mmol/l
15.56
370
855
154
130
14.51
157.50
4.2
2.9
38.68
34.35
umol/l
0.91
145
120
269
526
7.27
141.72
9.4
3.9
5.60
5.81
kpa
2.00
261
509
90
31
32.68
137.22
2.3
1.1
1.24
1.23
promille
0.01
71
21
490
1703
6.03
136.86
6.6
4.3
—
—
—
0
0
265
528
7.08
136.62
9.4
3.9
1.06
2.11
mmol/l
2.08
218
433
250
538
6.36
117.58
11.6
7.0
2.23
1.36
mmol/l
4.55
242
526
278
694
5.66
110.47
13.0
7.3
-0.72
1.17
mmol/l
3.59
199
532
277
701
5.57
108.11
13.1
7.2
11.72
12.08
kpa
0.62
262
668
277
701
5.57
108.11
13.2
7.2
4.54
5.09
kpa
7.95
264
667
259
631
5.64
105.29
13.4
7.6
95.64
95.41
%
0.19
252
609
216
459
6.12
101.79
7.5
3.3
4.73
4.60
kpa
0.25
208
446
216
487
5.75
94.95
16.7
8.3
—
—
—
0
0
282
832
4.74
89.41
4.0
2.2
2.16
2.30
g/l
3.19
264
774
227
566
5.24
88.42
14.5
8.1
115.43
122.01
g/l
4.15
221
549
102
111
10.42
86.73
7.4
3.2
—
—
—
0
0
539
2588
4.48
86.72
9.9
4.5
32.00
35.45
g/l
29.05
511
2384
426
1738
4.19
86.30
3.4
2.0
338.11
249.74
u/l
0.69
408
1634
193
430
5.63
85.32
7.8
3.7
7.39
7.41
ph
0.52
41
51
266
782
4.64
84.12
4.2
2.3
21.00
23.39
%
1.90
236
682
454
1973
4.10
83.17
5.9
3.6
20.60
6.30
mg/mmol
4.22
338
1246
442
1900
4.05
81.94
5.2
2.4
65.60
60.52
u/l
0.70
422
1742
223
582
4.96
81.67
2.7
2.3
0.20
0.21
g/l
1.08
200
544
599
3188
4.76
81.49
11.0
6.4
11.98
12.27
umol/l
0.17
580
3025
285
905
4.38
81.04
4.1
2.3
11.45
13.49
umol/l
4.43
267
849
435
1868
3.99
80.35
4.9
3.1
108.47
293.89
mg/l
1.35
337
1201
446
1965
3.96
78.93
5.0
3.0
6.48
8.02
mmol/l
12.66
382
1635
569
2989
4.32
76.99
18.1
6.2
1.17
1.21
mmol/l
19.03
485
2536
371
1468
3.91
76.49
3.1
2.1
3.46
3.13
mg/l
1.27
328
1240
564
2955
4.26
76.34
24.2
14.7
1.29
1.32
inr
0.28
183
867
536
2743
4.03
74.35
17.4
5.5
1.18
1.21
mmol/l
15.72
513
2475
46
19
25.66
65.18
2.5
1.6
147.91
42.38
umol/l
1.13
23
13
378
1667
3.45
63.20
5.1
2.9
—
—
—
0
0
166
422
4.72
61.54
10.2
4.7
—
—
—
0
0
609
3643
4.04
61.52
13.7
4.4
8.14
6.73
mmol/l
22.01
601
3398
129
271
5.50
59.80
2.0
2.1
1.64
1.55
g/l
0.46
121
236
148
356
4.89
58.57
6.5
2.9
122.90
130.18
g/l
2.85
143
347
137
313
5.09
57.60
14.3
9.6
21.42
24.49
mmol/l
6.51
130
306
154
388
4.70
57.51
15.0
7.0
20.40
24.30
mmol/l
9.64
148
367
149
368
4.77
57.01
6.4
3.5
129.12
85.43
ng/l
2.85
125
323
167
465
4.30
54.65
2.3
2.3
398.07
353.70
nmol/l
1.40
150
431
449
2334
3.17
54.64
4.7
2.5
203.53
159.54
ug/l
1.45
416
2121
82
121
7.45
53.98
9.4
3.8
2.89
2.48
mmol/l
0.41
53
82
287
1162
3.32
53.53
2.3
1.7
1319.32
1189.65
nmol/l
1.17
232
875
122
270
5.17
53.06
2.3
2.0
2.59
2.49
ug/l
0.03
102
241
89
149
6.61
52.05
9.3
3.5
7.38
7.42
ph
6.47
81
132
212
723
3.65
51.74
2.8
2.8
1.98
1.72
%
2.79
192
653
379
1850
3.03
50.49
5.1
3.2
44.93
33.08
u/l
2.37
358
1749
80
125
7.02
49.91
4.8
2.3
16.12
16.74
%
0.44
53
64
75
116
7.05
47.19
5.0
2.6
—
—
—
0
0
128
326
4.50
46.69
8.5
4.0
—
—
—
0
0
170
539
3.75
45.82
2.8
3.1
69.67
68.66
e9/l
0.14
144
424
366
1832
2.88
45.33
3.8
2.9
3447.29
1290.79
ng/l
5.90
332
1566
433
2369
2.85
45.20
7.2
3.3
177.62
71.28
ng/l
0.47
381
1724
230
891
3.24
45.13
2.4
2.1
31.02
29.82
s
1.40
225
862
53
59
9.56
43.81
1.9
1.2
69.32
71.55
mmol/l
0.09
38
47
442
2477
2.80
43.51
2.9
2.0
87.06
94.61
pmol/l
2.50
275
1287
348
1728
2.83
43.30
9.3
3.5
7.37
7.40
ph
3.18
91
352
69
110
6.78
42.13
4.9
3.9
—
—
—
0
0
224
890
3.13
41.71
2.4
2.0
—
—
—
0
0
184
665
3.31
40.04
4.6
2.8
8.89
9.15
umol/l
0.06
160
594
67
111
6.51
39.39
1.7
1.3
0.75
0.82
nmol/l
0.29
58
93
297
1425
2.75
38.59
2.0
1.5
20.01
20.35
nmol/l
0.12
258
1180
279
1304
2.77
38.06
2.0
1.7
456.94
34791124.91
pmol/l
1.29
235
1075
110
301
4.09
36.14
17.7
9.5
—
—
—
0
0
397
2276
2.51
34.80
3.3
2.1
68.37
77.77
nmol/l
8.00
364
1995
182
706
3.06
34.70
2.3
1.6
—
—
—
0
0
654
4780
3.25
34.60
15.1
7.3
92.19
78.64
u/l
6.91
638
4458
480
3010
2.54
34.53
7.2
5.8
0.04
0.04
e9/l
0.48
428
2613
381
2149
2.51
34.52
6.3
3.5
98.86
107.36
e6/l
0.08
309
1587
349
1898
2.51
34.12
5.7
3.0
178.33
108.28
e6/l
0.27
307
1486
476
2997
2.50
33.58
7.1
5.8
0.67
0.59
e9/l
6.85
425
2603
456
2819
2.48
33.44
8.3
6.5
—
—
—
0
0
445
2726
2.47
33.22
7.8
6.0
0.66
0.67
%
0.22
421
2543
573
3946
2.69
33.21
7.5
4.1
236.70
2298.15
e6/l
—
10
62
455
2825
2.46
32.82
8.3
6.4
8.91
8.86
%
0.11
432
2644
150
536
3.23
32.78
4.7
2.6
42.98
43.11
u/l
0.00
133
465
482
3073
2.48
32.76
7.4
5.9
1.88
2.01
e9/l
0.32
435
2741
345
1900
2.46
32.40
4.0
2.4
—
—
—
0
0
452
2812
2.44
32.25
7.9
6.1
2.46
2.93
%
4.87
428
2628
483
3097
2.46
32.18
7.7
6.1
0.20
0.20
e9/l
0.02
432
2741
523
3478
2.52
32.13
11.8
9.2
4.91
4.08
e9/l
9.21
476
3050
459
2879
2.44
32.10
8.2
6.2
23.33
27.77
%
13.53
435
2701
41
49
8.77
31.99
1.3
1.2
1.09
1.61
nmol/l
1.62
36
41
359
2036
2.41
31.30
4.3
3.3
2.29
2.35
mmol/l
5.83
321
1772
96
265
3.99
31.02
10.5
4.5
—
—
—
0
0
50
79
6.69
30.67
3.1
1.3
87.37
89.49
%
0.89
50
79
309
1655
2.43
30.44
3.9
2.7
402.10
5223.29
umol/l
4.79
264
1425
321
1758
2.40
29.98
5.6
2.9
0.93
0.49
e6/l
2.23
281
1353
144
530
3.10
29.76
3.5
2.3
7.67
7.20
ug/l
0.13
125
473
251
1237
2.52
29.51
5.9
2.7
472.42
571.74
mosm/kgh2o
11.86
229
1054
446
2842
2.33
28.95
7.9
5.9
60.80
56.92
%
8.40
422
2666
445
2866
2.28
27.71
3.9
2.5
—
—
—
0
0
138
516
3.03
27.63
2.4
2.7
65.04
66.74
g/l
1.18
128
474
37
47
8.21
27.46
1.7
1.5
284.84
283.14
mosm/kgh2o
0.13
31
37
578
4173
2.48
27.33
7.4
4.0
—
—
—
0
0
67
156
4.60
26.99
5.3
4.9
2.20
1.47
mg/l
7.28
61
140
141
548
2.92
26.27
2.0
1.5
—
—
—
0
0
69
169
4.38
26.07
11.9
6.0
2.47
1.22
mmol/l
3.10
60
143
67
162
4.43
25.73
1.6
1.5
246.48
268.25
ug/g
0.29
40
95
80
221
3.92
25.72
4.1
3.4
0.53
0.20
g/l
2.60
51
93
545
3886
2.33
25.68
7.1
3.0
116.02
51.29
u/l
11.97
517
3582
254
1332
2.34
25.40
5.1
2.4
5.92
4.22
e6/l
1.56
236
1195
300
1695
2.25
25.05
5.6
2.9
—
—
—
0
0
217
1090
2.37
23.73
5.6
3.5
377.35
424.30
ng/l
0.10
186
872
268
1480
2.23
23.35
3.9
2.3
—
—
—
0
0
267
1490
2.20
22.52
9.0
3.8
82.07
87.31
%
2.38
259
1459
58
139
4.43
22.49
1.3
1.2
230.00
106.25
titre
—
7
8
69
196
3.76
21.26
2.1
3.7
60.52
82.60
mg/l
0.30
51
161
69
196
3.76
21.26
2.1
3.7
55.23
52.36
mg/l
0.06
51
164
228
1219
2.23
21.19
2.1
1.7
1.81
1.32
mg/l
1.15
195
934
60
157
4.06
20.73
2.6
2.3
123.22
135.26
ug/min
0.07
40
92
121
489
2.74
20.70
3.2
2.8
400.11
190.44
ng/l
2.20
109
449
430
2944
2.02
20.39
5.9
3.4
0.00
0.00
estimate
-0.00
105
604
113
445
2.80
20.29
2.0
2.6
—
—
—
0
0
359
2336
1.99
19.36
5.2
3.2
5.40
5.84
ph
—
10
160
138
621
2.48
18.88
2.1
1.5
—
—
—
0
0
41
89
4.81
17.93
1.1
1.1
44.22
38.59
iu/ml
—
9
17
422
2955
1.93
17.84
5.9
3.5
0.00
0.00
estimate
-0.00
94
541
36
70
5.34
17.84
1.8
1.6
—
—
—
0
0
54
149
3.82
17.32
2.3
4.0
—
—
—
0
0
41
93
4.60
17.01
9.7
2.1
—
—
—
0
0
23
9
26.27
16.98
1.8
1.1
—
—
—
0
0
24
33
7.47
16.60
1.0
1.1
—
—
—
0
0
413
2921
1.88
16.43
7.7
4.6
0.00
0.00
estimate
-0.00
101
568
194
1066
2.09
16.26
3.8
2.6
1.28
1.04
e6/l
0.52
132
630
42
101
4.34
16.20
2.5
4.8
2.40
0.86
%
1.46
36
92
24
34
7.25
16.18
2.9
7.5
10.52
11.91
%
0.72
24
34
23
32
7.38
15.74
1.0
1.0
—
—
—
0
0
23
32
7.38
15.74
2.8
4.2
7.38
7.42
ph
0.67
11
15
181
982
2.10
15.62
3.9
2.8
2.31
1.47
e6/l
0.47
119
551
242
1460
1.95
15.51
8.4
6.9
—
—
—
0
0
106
463
2.49
15.31
2.6
2.8
11.39
10.72
g/l
0.60
98
428
46
126
3.82
14.91
2.5
1.4
—
—
—
0
0
78
299
2.79
14.62
1.7
1.2
—
—
—
0
0
110
503
2.38
14.34
11.4
3.1
1.19
1.22
mmol/l
3.97
104
437
23
36
6.55
14.16
2.9
3.8
—
—
—
0
0
47
137
3.59
13.93
2.4
1.4
—
—
—
0
0
31
67
4.78
13.63
1.5
1.5
—
—
—
0
0
41
111
3.84
13.51
1.8
1.4
—
—
—
0
0
47
140
3.51
13.48
2.4
1.4
—
—
—
0
0
36
89
4.19
13.41
6.9
7.0
12.94
11.06
mg/l
1.28
30
80
46
138
3.48
13.06
2.4
1.4
—
—
—
0
0
109
520
2.27
12.84
4.3
4.7
0.79
0.93
%
0.35
59
196
46
140
3.43
12.78
2.5
1.4
—
—
—
0
0
37
97
3.95
12.75
1.8
2.8
—
—
—
0
0
85
365
2.49
12.68
1.6
1.8
1.22
1.58
g/l
0.78
79
335
218
1350
1.85
12.48
5.0
3.5
—
—
—
0
0
141
754
2.06
12.43
2.2
1.7
—
—
—
0
0
21
17
12.66
12.17
1.5
1.3
—
—
—
0
0
18
11
16.72
11.70
2.1
2.2
—
—
—
0
0
41
123
3.46
11.65
2.5
1.3
—
—
—
0
0
21
37
5.80
11.53
3.1
3.3
—
—
—
0
0
101
489
2.22
11.45
4.3
4.8
0.08
0.12
%
0.29
49
167
256
1703
1.75
11.35
6.6
3.7
0.00
0.00
estimate
-0.00
88
545
32
85
3.88
10.85
1.0
1.1
—
—
—
0
0
96
470
2.19
10.57
3.8
4.6
0.69
0.54
%
0.44
49
170
279
1936
1.69
10.43
6.3
3.5
—
—
—
0
0
17
13
13.34
10.19
1.7
1.5
1.75
2.09
mmol/l
—
11
8
30
80
3.86
10.12
2.0
5.2
—
—
—
0
0
186
1165
1.78
9.98
3.9
3.2
2.48
2.44
mmol/l
1.64
169
1018
691
6139
2.08
9.96
42.1
13.4
29.06
25.96
mg/l
1.76
662
4805
366
2749
1.62
9.88
20.7
9.3
0.00
0.00
e9/l
0.39
312
2269
29
78
3.82
9.67
1.0
1.1
—
—
—
0
0
103
536
2.06
9.67
8.2
3.6
—
—
—
0
0
34
103
3.41
9.54
1.7
1.4
—
—
—
0
0
92
462
2.12
9.48
4.2
4.8
0.00
0.73
%
0.62
41
142
77
362
2.25
9.35
1.7
1.4
—
—
—
0
0
24
58
4.24
9.23
1.6
1.5
—
—
—
0
0
25
63
4.07
9.11
3.4
2.5
1.55
2.05
g/24h
0.17
16
28
26
68
3.92
9.02
1.3
2.1
—
—
—
0
0
32
97
3.40
8.98
2.8
1.7
—
—
—
0
0
127
730
1.88
8.93
1.4
1.3
502.86
446.34
titre
0.13
21
164
16
15
10.86
8.82
6.4
5.0
—
—
—
0
0
29
85
3.50
8.57
1.5
1.5
29.46
32.42
g/l
0.51
22
78
26
71
3.75
8.51
1.6
1.4
2369.11
1285.79
e6/l
0.27
18
52
522
4363
1.59
8.34
4.3
3.5
14.85
14.91
pmol/l
0.17
465
3885
536
4510
1.60
8.30
5.1
3.9
21.49
12.24
mm/h
18.82
499
4127
34
113
3.10
8.25
1.7
1.2
281.75
276.55
u/ml
0.03
16
69
24
66
3.72
7.79
1.6
1.4
89671.00
64805.79
e6/l
0.12
15
39
25
71
3.60
7.75
2.6
4.9
66.50
52.19
%
1.75
19
62
14
14
10.16
7.55
1.9
1.6
—
—
—
0
0
33
114
2.98
7.51
2.8
1.4
113.00
147.29
u/ml
0.31
11
17
655
5856
1.73
7.35
11.4
5.5
47.78
39.74
mmol/mol
35.10
620
5350
17
25
6.92
7.32
2.6
2.4
53182.35
41476.00
ug/l
0.78
17
25
39
150
2.68
7.31
1.3
1.7
—
—
—
0
0
619
5458
1.64
7.27
5.6
4.2
2.08
1.96
mu/l
1.27
569
4877
22
60
3.74
7.23
3.5
2.5
—
—
—
0
0
110
645
1.82
7.22
9.6
3.7
—
—
—
0
0
20
51
4.00
7.20
1.6
1.4
—
—
—
0
0
33
119
2.85
6.98
3.2
3.2
62.00
56.58
%
1.30
33
119
113
675
1.79
6.97
4.6
4.4
5.43
30.56
ug/l
1.29
98
558
17
27
6.41
6.96
1.1
1.0
148.71
131.00
nmol/l
0.64
17
27
193
1337
1.59
6.79
5.6
3.7
1.02
1.02
kg/l
0.65
28
187
98
568
1.83
6.67
5.3
3.1
—
—
—
0
0
23
69
3.40
6.59
2.3
2.1
—
—
—
0
0
61
302
2.11
6.54
3.6
2.7
—
—
—
0
0
20
56
3.64
6.35
1.2
1.3
11.92
28.92
%
2.01
12
37
40
172
2.40
6.00
1.7
1.2
—
—
—
0
0
28
101
2.84
5.95
2.0
2.3
—
—
—
0
0
26
90
2.95
5.94
1.6
2.8
32.92
32.62
pg
0.11
26
90
13
19
6.94
5.75
2.8
2.6
—
—
—
0
0
155
1058
1.58
5.73
2.0
1.4
3.55
2.65
g/l
2.68
108
629
133
875
1.63
5.72
1.4
1.2
—
—
—
0
0
22
71
3.16
5.65
2.0
1.8
4975.26
3187.62
u/l
—
9
24
9
7
12.99
5.59
6.3
5.3
—
—
—
0
0
43
198
2.24
5.54
2.0
2.4
33.14
37.47
g/l
2.95
36
177
12
17
7.15
5.45
1.9
1.4
—
—
—
0
0
8
5
16.15
5.42
5.8
6.0
—
—
—
0
0
30
119
2.58
5.35
1.2
1.6
—
—
—
0
0
47
228
2.13
5.34
2.0
2.5
10.50
11.08
g/l
0.26
40
206
33
138
2.45
5.28
3.4
3.0
0.83
0.86
nmol/l
0.17
23
106
29
114
2.60
5.26
3.3
2.9
4.73
4.21
e9/l
0.65
29
114
5
0
+∞
5.21
1.8
0.0
111.20
—
mmol/l
—
5
0
36
161
2.30
4.99
1.3
1.2
—
—
—
0
0
211
1582
1.46
4.94
6.3
3.2
—
—
—
0
0
39
183
2.19
4.83
7.2
3.3
—
—
—
0
0
9
10
9.09
4.79
1.6
1.3
80.89
63.10
nmol/24h
—
9
10
14
30
4.73
4.69
25.6
17.1
2117.57
1351.30
nmol/l
1.05
14
30
13
26
5.07
4.64
1.0
1.7
50.69
54.67
mg/l
0.12
13
21
20
69
2.95
4.63
1.4
1.1
—
—
—
0
0
507
4463
1.39
4.48
5.7
3.8
—
—
—
0
0
10
15
6.74
4.47
1.2
1.5
157.20
157.31
mmol/24h
—
10
15
700
6553
1.65
4.46
54.2
15.3
138.57
139.79
mmol/l
26.27
692
6360
14
32
4.44
4.45
1.9
1.3
—
—
—
0
0
23
88
2.66
4.43
1.9
1.1
—
—
—
0
0
17
55
3.14
4.38
1.6
1.5
—
—
nmol/l
—
0
0
12
24
5.06
4.33
3.5
2.6
—
—
—
0
0
18
458
0.38
4.32
1.2
1.4
—
—
—
0
0
10
16
6.32
4.30
2.5
4.9
51.80
46.53
%
—
10
16
11
20
5.56
4.30
1.0
1.1
—
—
—
0
0
11
20
5.56
4.30
1.0
1.0
—
—
—
0
0
8
9
8.97
4.28
3.6
13.7
4.29
6.83
mmol/l
—
8
9
109
733
1.57
4.26
1.5
1.4
—
—
—
0
0
14
34
4.17
4.22
1.1
1.4
—
—
—
0
0
9
13
6.99
4.17
1.8
1.3
—
—
—
0
0
701
6584
1.62
4.16
53.8
15.4
4.06
4.00
mmol/l
5.68
691
6378
14
35
4.05
4.11
6.6
1.4
11.89
9.06
mmol/l
2.06
14
35
7
7
10.08
4.01
1.9
1.4
1.17
1.17
mmol/l
—
7
7
10
323
0.30
3.92
1.2
1.4
—
—
—
0
0
157
1159
1.44
3.91
1.4
1.2
1.20
1.69
u/ml
0.50
40
310
17
60
2.87
3.81
1.1
1.1
—
—
—
0
0
32
154
2.12
3.77
1.7
1.6
19197.41
14106.05
e6/l
0.28
22
111
18
67
2.73
3.68
5.2
2.5
—
—
—
0
0
18
67
2.73
3.68
1.1
1.6
79.38
60.98
%
—
8
46
9
17
5.34
3.51
1.1
1.0
—
—
—
0
0
17
63
2.74
3.51
1.1
1.1
—
—
—
0
0
12
32
3.79
3.40
1.5
1.7
—
—
—
0
0
208
1650
1.36
3.36
1.5
1.3
—
—
—
0
0
14
49
2.89
3.20
1.1
1.3
—
—
—
0
0
91
628
1.51
3.18
2.3
2.3
169.76
131.69
ug/g
0.56
76
489
684
6462
1.47
3.15
40.3
12.9
—
—
—
0
0
7
212
0.32
3.10
1.7
1.6
—
—
—
0
0
14
50
2.83
3.10
1.1
1.3
0.33
0.44
g/l
—
9
35
14
50
2.83
3.10
1.1
1.3
2.38
3.03
g/l
—
8
37
14
50
2.83
3.10
1.1
1.3
10.62
7.55
g/l
—
9
36
25
119
2.14
3.07
1.2
1.9
—
—
—
0
0
15
56
2.71
3.07
1.8
1.4
—
—
—
0
0
29
147
2.01
3.03
1.2
1.7
1.00
28.11
e6/l
0.69
21
114
7
12
5.87
3.02
1.1
1.0
—
—
—
0
0
20
88
2.31
2.95
1.3
1.7
0.56
0.89
g/l
1.03
15
71
17
73
2.36
2.66
1.5
1.6
—
—
—
0
0
12
43
2.82
2.65
1.2
1.6
—
—
—
0
0
41
244
1.72
2.65
3.0
3.6
406.42
5059.27
u/ml
0.57
36
201
5
7
7.18
2.55
1.2
1.4
—
—
—
0
0
15
62
2.45
2.55
2.1
2.3
—
—
—
0
0
15
62
2.45
2.55
1.1
1.1
—
—
—
0
0
23
115
2.03
2.53
1.3
2.3
—
—
—
0
0
20
95
2.13
2.50
1.3
1.4
—
—
—
0
0
17
76
2.26
2.45
1.2
1.2
—
—
—
0
0
13
51
2.58
2.45
1.0
1.1
—
—
—
0
0
157
1942
0.76
2.44
2.5
3.0
0.81
0.74
ug/l
0.71
112
1319
15
64
2.37
2.40
1.2
2.0
—
—
—
0
0
8
22
3.66
2.37
2.3
5.5
—
—
—
0
0
12
46
2.63
2.36
1.6
1.3
—
—
—
0
0
98
728
1.40
2.36
1.6
1.3
—
—
—
0
0
79
567
1.44
2.31
1.4
1.4
—
—
—
0
0
25
134
1.89
2.29
1.2
1.7
—
—
—
0
0
6
13
4.64
2.27
3.5
1.9
—
—
—
0
0
20
100
2.03
2.22
1.4
1.6
—
—
—
0
0
7
20
3.52
2.06
1.0
1.0
1964.14
1183.15
miu/ml
—
7
20
6
15
4.02
2.04
1.3
1.2
-1.10
2.87
mmol/l
—
6
15
14
63
2.24
2.02
1.4
2.3
—
—
—
0
0
41
268
1.56
1.91
2.7
1.6
—
—
—
0
0
18
93
1.96
1.86
1.6
1.6
3.69
5.20
iu/l
—
9
26
43
629
0.67
1.86
1.5
1.5
—
—
—
0
0
33
206
1.63
1.86
11.5
10.3
—
—
—
0
0
690
6648
1.32
1.75
21.6
10.0
32.82
26.68
u/l
1.38
676
6358
6
18
3.35
1.75
1.0
1.1
—
—
—
0
0
45
307
1.49
1.75
2.8
2.4
—
—
—
0
0
12
54
2.24
1.74
1.3
1.2
—
—
—
0
0
9
36
2.52
1.74
1.1
1.3
—
—
—
0
0
9
195
0.46
1.74
1.9
1.7
—
—
—
0
0
55
392
1.43
1.72
3.5
2.9
—
—
—
0
0
5
13
3.86
1.71
1.0
1.1
—
—
—
0
0
43
293
1.49
1.68
8.4
3.5
—
—
—
0
0
12
55
2.20
1.68
1.1
1.2
—
—
—
0
0
11
49
2.26
1.64
1.7
2.1
2.17
2.09
u/field
—
6
23
102
811
1.30
1.61
1.4
1.3
—
—
—
0
0
24
145
1.68
1.55
4.4
2.4
—
—
—
0
0
5
15
3.35
1.52
1.0
1.0
—
—
—
0
0
25
156
1.62
1.45
1.3
1.1
—
—
—
0
0
185
2123
0.83
1.40
4.3
2.8
—
—
—
0
0
558
5296
1.19
1.38
44.4
15.8
16.30
15.25
%
3.76
550
5191
25
382
0.64
1.37
1.3
1.4
—
—
—
0
0
42
301
1.42
1.32
1.2
1.2
107.40
138.05
iu/ml
0.34
16
122
56
422
1.35
1.31
3.4
2.8
4.73
5.25
e9/l
0.18
39
337
29
193
1.52
1.31
1.6
1.6
—
—
—
0
0
5
18
2.79
1.28
2.4
1.3
—
—
—
0
0
8
35
2.30
1.27
1.0
1.1
—
—
—
0
0
12
207
0.57
1.11
2.3
1.7
34.58
42.06
nmol/l
0.72
12
200
631
6100
1.18
1.04
6.8
4.6
7.34
5.97
mmol/l
24.86
579
5465
18
114
1.59
1.03
1.4
1.3
—
—
—
0
0
5
23
2.18
0.98
1.0
1.0
—
—
—
0
0
69
564
1.25
0.94
1.7
1.4
—
—
—
0
0
609
5890
1.15
0.91
5.4
3.9
1.64
1.28
mmol/l
10.83
552
5312
14
217
0.64
0.88
1.4
1.2
—
—
—
0
0
8
46
1.75
0.82
1.4
1.1
—
—
—
0
0
9
150
0.60
0.79
2.8
1.9
137.78
226.81
pmol/l
—
9
140
5
24
2.09
0.74
1.0
1.5
—
—
—
0
0
38
300
1.28
0.72
2.4
1.6
—
—
—
0
0
7
40
1.76
0.71
1.0
1.1
—
—
—
0
0
7
41
1.71
0.70
12.7
2.6
—
—
—
0
0
5
28
1.79
0.66
1.0
17.7
—
—
—
0
0
642
6282
1.12
0.59
6.3
4.8
2.19
2.74
mmol/l
47.38
587
5683
49
412
1.20
0.56
1.3
1.2
—
—
—
0
0
10
65
1.55
0.55
11.0
2.6
—
—
—
0
0
6
37
1.63
0.55
1.2
1.4
—
—
—
0
0
6
98
0.61
0.52
1.3
1.3
—
—
—
0
0
29
357
0.81
0.51
1.2
1.3
—
—
—
0
0
703
6936
1.13
0.47
57.4
19.9
7.88
6.69
e9/l
6.61
691
6694
5
81
0.61
0.46
1.0
1.1
—
—
—
0
0
5
81
0.61
0.46
1.0
1.1
—
—
—
0
0
20
156
1.29
0.45
13.3
4.7
—
—
—
0
0
12
163
0.73
0.44
1.0
1.1
—
—
—
0
0
11
78
1.42
0.43
1.2
1.4
—
—
—
0
0
702
6932
1.12
0.43
59.0
19.9
37.05
40.59
%
32.28
653
6461
5
32
1.57
0.42
1.6
1.3
—
—
—
0
0
10
70
1.43
0.42
1.2
1.3
—
—
—
0
0
626
6151
1.09
0.41
5.7
4.4
4.09
4.60
mmol/l
27.67
573
5623
702
6935
1.12
0.41
57.5
19.9
245.16
240.45
e9/l
0.85
692
6716
0
17
0.00
0.40
0.0
1.3
—
—
—
0
0
702
6937
1.12
0.40
57.3
19.8
92.70
91.31
fl
8.46
694
6797
702
6937
1.12
0.40
57.2
19.8
30.55
30.45
pg
0.54
694
6795
17
215
0.79
0.39
1.0
1.1
—
—
—
0
0
5
35
1.43
0.39
1.2
1.3
0.66
1.01
g/l
—
5
35
5
35
1.43
0.39
2.6
2.3
2342.40
1595.14
u/ml
—
5
35
702
6938
1.12
0.39
57.5
19.8
4.10
4.53
e12/l
54.11
691
6692
702
6941
1.11
0.37
58.1
19.9
123.39
137.14
g/l
70.71
694
6795
13
168
0.77
0.36
1.0
1.1
—
—
—
0
0
10
74
1.36
0.32
1.3
1.1
—
—
—
0
0
619
6103
1.07
0.30
5.7
4.3
1.31
1.43
mmol/l
9.19
567
5531
17
139
1.23
0.29
3.1
3.6
70.11
25.70
mg/l
1.58
12
88
82
884
0.92
0.28
1.3
1.2
9.25
13.10
u/ml
0.44
25
330
23
266
0.86
0.25
1.3
1.3
—
—
—
0
0
5
42
1.19
0.21
2.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
3.6
—
6.04
—
0
14
6
49
1.23
0.20
2.0
1.4
87.50
81.73
umol/l
—
6
49
318
3249
0.96
0.18
4.7
4.9
3.17
3.02
ug/l
0.09
280
2898
248
2416
1.04
0.18
2.4
2.1
—
—
—
0
0
89
934
0.95
0.16
1.3
1.3
49.63
36.59
iu/ml
0.16
28
281
57
607
0.93
0.16
2.4
2.2
10.41
13.64
nmol/l
2.03
45
549
48
451
1.07
0.14
1.3
1.4
—
—
—
0
0
172
1680
1.03
0.11
2.0
1.6
1.72
1.34
mmol/l
3.14
142
1364
5
45
1.11
0.10
1.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
2.86
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
17.66
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
-0.00
1.1
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.0
679.40
661.84
ng/l
—
5
31
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_ACIDOSIS and mortality.

Females

Parameter HR [95% CI] p-value
E4_ACIDOSIS 4.343 [3.3, 5.71] < 0.001
Birth year 0.997 [0.99, 1.01] 0.601

During the follow-up period (1.1.1998 — 31.12.2019), 482 out of 1194 females with E4_ACIDOSIS died.

Males

Parameter HR [95% CI] p-value
E4_ACIDOSIS 5.206 [4.09, 6.63] < 0.001
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 864 out of 2128 males with E4_ACIDOSIS died.

Mortality risk

Mortality risk for people of age

years, who have E4_ACIDOSIS.

N-year risk Females Males
1 0.48% 0.771%
5 2.92% 5.339%
10 6.434% 13.916%
15 12.782% 25.455%
20 22.326% 39.972%

Relationships between endpoints

↥

Index endpoint: E4_ACIDOSIS – Acidosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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