pulmonary edema: Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
654 |
4. Check minimum number of eventsNone |
654 |
5. Include endpointsNone |
654 |
6. Filter based on genotype QC (FinnGen only) |
654 |
Control definitions (FinnGen only)
- Control exclude
- J10_INTERSTITIUM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- J80-J84
- Name in latin
- Oedema pulmonum
Similar endpoints
↥List of similar endpoints to
Pulmonary oedema
based on the number of shared cases.
Similar with more cases:
- Other respiratory diseases principally affecting the interstitium
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
- COPD differential diagnosis
- ILD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9006 | 4604 | 4219 |
| Only index persons | 5204 | 2779 | 2425 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.13 | 0.12 |
| Only index persons | 0.10 | 0.10 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 77.49 | 80.34 | 74.43 |
| Only index persons | 76.85 | 79.98 | 73.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 654 | 239 | 415 |
| Unadjusted period prevalence (%) | 0.15 | 0.08 | 0.18 |
| Median age at first event (years) | 73.35 | 73.78 | 73.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 604
- Matched controls
- 6036
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J81
ICD-10 Finland
Pulmonary oedema
+∞
323.0
604
*
C03CA01
ATC
furosemide; systemic
7.1
99.4
475
2067
I50.9
ICD-10 Finland
Heart failure, unspecified
5.8
84.2
328
1024
I50.0
ICD-10 Finland
Congestive heart failure
6.9
78.1
230
493
I50.1
ICD-10 Finland
Left ventricular failure
7.1
57.4
155
279
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.6
51.6
218
657
WX722
NOMESCO Finland
PEEP
7.7
40.6
100
152
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.0
35.4
294
1435
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
3.2
33.5
238
1031
C01DA14
ATC
isosorbide mononitrate; oral
3.0
32.4
249
1135
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
31.3
278
1385
TK800
NOMESCO Finland
Hemodialysis
10.2
31.2
63
68
WX872
NOMESCO Finland
Intensive care
6.4
31.1
86
152
I25.2
ICD-10 Finland
Old myocardial infarction
4.1
29.7
130
380
C07AB07
ATC
bisoprolol; oral
2.7
28.5
392
2477
Z49.1
ICD-10 Finland
Extracorporeal dialysis
13.2
28.3
50
41
C03DA01
ATC
spironolactone; oral
3.6
28.2
147
497
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
8.9
27.5
60
74
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.9
26.0
61
85
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.0
25.7
185
783
AN1
HP
Coronary angiography
3.3
25.5
152
564
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.6
24.4
241
1229
TPH07
NOMESCO Finland
Cathetrisation of artery
3.6
23.2
117
380
103
Kela drug reimbursment
Diabetes, insulin-treated
2.5
22.8
251
1346
201
Kela drug reimbursment
Chronic cardiac insufficiency
3.5
22.4
117
390
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
3.9
22.0
97
281
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.7
22.0
104
320
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.4
21.4
267
1510
J96.0
ICD-10 Finland
Acute respiratory failure
11.2
20.7
39
37
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.4
20.5
224
1177
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
10.1
19.6
39
41
N18.8
ICD-10 Finland
Other chronic renal failure
5.6
19.3
58
113
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.8
19.1
86
253
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.7
19.0
157
704
R06.0
ICD-10 Finland
Dyspnoea
2.4
18.3
191
970
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
14.9
18.3
30
21
205
Kela drug reimbursment
Chronic hypertension
2.2
18.1
287
1777
WX730
NOMESCO Finland
Conventional respirator
8.6
18.0
39
48
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.8
17.6
130
541
C01AA05
ATC
digoxin; systemic
2.6
17.4
145
647
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
17.4
170
833
B01AA03
ATC
warfarin; systemic
2.2
17.3
232
1324
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.2
17.1
99
352
A10AE04
ATC
insulin glargine; parenteral
3.2
17.0
98
346
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.9
16.8
72
202
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
+∞
16.7
16
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
16.5
160
776
WX882
NOMESCO Finland
High dependency care
6.1
16.3
45
79
WX892
NOMESCO Finland
Monitored bed care
3.6
16.1
75
226
A12AA04
ATC
calcium carbonate; oral
7.3
15.9
38
55
B01AC04
ATC
clopidogrel; oral
2.4
15.8
154
746
V03AE01
ATC
polystyrene sulfonate; oral
8.9
15.7
33
39
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
15.6
137
627
A12BA01
ATC
potassium chloride; oral
3.2
15.4
87
304
ZX120
NOMESCO Finland
Intravenous
3.2
14.9
83
286
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.3
14.8
39
65
C09AA05
ATC
ramipril; oral
2.1
14.7
215
1252
WX725
NOMESCO Finland
Noninvasive ventilation
5.1
14.7
47
99
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
5.2
14.6
46
95
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.7
14.5
111
470
A11CC03
ATC
alfacalcidol; systemic
5.1
14.5
46
96
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
9.2
14.1
29
33
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
3.5
14.1
68
211
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.7
14.1
28
30
A10AA02
ATC
NA
4.3
14.0
52
128
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
4.6
14.0
49
114
L04AA06
ATC
mycophenolic acid; systemic
11.8
13.9
25
22
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.0
13.9
243
1518
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
16.7
13.5
21
13
A10BA02
ATC
metformin; oral
2.0
13.4
218
1315
N18.0
ICD-10 Finland
End-stage renal disease
6.6
13.4
34
54
WX704
NOMESCO Finland
Intubation
3.6
13.3
62
187
C08CA01
ATC
amlodipine; oral
1.9
13.2
270
1778
127
Kela drug reimbursment
Transplant complication
11.3
13.1
24
22
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
19.5
13.0
19
10
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.7
12.9
98
409
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
4.1
12.8
50
130
B03XA02
ATC
darbepoetin alfa; parenteral
5.9
12.7
35
62
I21.41
ICD-10 Finland
Acute subendocardial infarction stenosed coronary artery
3.5
12.6
59
179
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
5.6
12.6
36
67
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
+∞
12.5
12
*
J80
ICD-10 Finland
Adult respiratory distress syndrome
+∞
12.5
12
*
A10BB12
ATC
glimepiride; oral
2.6
12.5
94
394
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
12.4
220
1365
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.5
12.4
59
181
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
12.4
149
791
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.6
12.3
97
415
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
8.0
12.2
27
35
TKC20
NOMESCO Finland
Catheterisation of bladder
2.7
12.2
86
347
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.7
12.1
87
352
I20.09
ICD-10 Finland
Unstable angina
3.1
12.0
69
244
A10AA01
ATC
NA
6.3
12.0
31
51
I42.0
ICD-10 Finland
Dilated cardiomyopathy
5.1
11.9
37
76
C09AA02
ATC
enalapril; systemic
2.0
11.9
181
1055
I21.99
ICD-10 Finland
Myocardial infarction (acute) UNS unspecified coronary artery status
3.6
11.8
53
156
WW500
NOMESCO Finland
Blood transfusion
4.2
11.7
44
110
C01BD01
ATC
amiodarone; systemic
4.5
11.7
41
96
Z94.0
ICD-10 Finland
Kidney transplant status
11.4
11.6
21
19
A98
ICPC
Health maint/preventive medicine
0.5
11.4
315
4014
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.0
11.4
69
252
196
Kela drug reimbursment
Paricalcitol and cinacalcet
15.4
11.4
18
12
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
20.5
11.2
16
8
A10AE05
ATC
insulin detemir; parenteral
3.5
11.2
53
163
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
6.5
11.0
28
45
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.6
10.9
81
335
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.3
10.7
39
95
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
2.9
10.7
66
245
A41.9
ICD-10 Finland
Sepsis, unspecified
3.8
10.6
45
126
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
3.2
10.6
57
193
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
2.4
10.3
93
426
A46
ICD-10 Finland
Erysipelas
2.2
10.3
111
556
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.6
10.1
77
324
V03AE02
ATC
sevelamer; oral
10.9
9.8
18
17
M04AA01
ATC
allopurinol; systemic
2.1
9.7
129
705
A10BB01
ATC
glibenclamide; oral
2.6
9.7
74
311
WX890
NOMESCO Finland
Intesive care monitoring
8.0
9.7
21
27
137
Kela drug reimbursment
Uraemia requiring dialysis
10.3
9.6
18
18
C02AC05
ATC
moxonidine; oral
3.2
9.5
50
167
L04AX01
ATC
azathioprine; systemic
5.0
9.4
29
60
I21.09
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
5.0
9.4
29
60
V03AE03
ATC
lanthanum carbonate; oral
22.1
9.4
13
6
I21.9
ICD-10 Finland
Acute myocardial infarction, unspecified
3.6
9.2
40
115
XCK10
NOMESCO Finland
Photography of fundus of eye
2.4
9.1
83
382
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
5.2
9.0
27
54
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
6.2
9.0
23
38
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
8.9
264
1888
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
12.8
8.9
15
12
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
8.8
143
841
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.1
8.8
47
159
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.1
8.8
47
159
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.9
8.8
149
893
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
3.2
8.7
45
149
C08CA02
ATC
felodipine; oral
2.2
8.7
98
498
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
8.4
8.6
18
22
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
11.8
8.6
15
13
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.4
8.5
72
318
81
HP
Angiography of the heart and coronary arteries
2.3
8.5
78
362
I81
ICD-10 Finland
Portal vein thrombosis
20.3
8.5
12
6
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.5
8.3
66
285
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
8.3
90
452
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
3.8
8.3
34
94
I47.2
ICD-10 Finland
Ventricular tachycardia
4.5
8.2
28
65
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.4
8.2
38
116
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
4.8
8.2
26
56
C10AA01
ATC
simvastatin; oral
1.6
8.0
310
2364
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
4.2
8.0
29
72
I21.40
ICD-10 Finland
Acute subendocardial infarction no detected stenosis of the coronary artery
3.4
7.9
37
114
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
13.2
7.9
13
10
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
4.9
7.8
24
50
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
0.3
7.8
21
594
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
4.3
7.7
27
65
11
HP
Coronary artery bypass surgery
3.5
7.6
34
101
N19
ICD-10 Finland
Unspecified kidney failure
3.0
7.6
43
150
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.8
7.6
48
181
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
9.0
7.6
15
17
1CX08
NOMESCO Finland
NA
10.2
7.6
14
14
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
10.2
7.6
14
14
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.8
7.6
48
182
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
7.5
54
220
S97
ICPC
Chronic ulcer skin
2.7
7.4
49
191
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
7.8
7.4
16
21
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
7.0
7.3
17
25
AN2
HP
Balloon angioplasty, including several vessels
3.5
7.3
32
94
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
+∞
7.3
7
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
5.5
7.3
20
37
J15.8
ICD-10 Finland
Other bacterial pneumonia
12.2
7.1
12
10
Z49.2
ICD-10 Finland
Other dialysis
8.9
7.1
14
16
H3603, E103
ICD-10 Finland
NA
10.2
7.1
13
13
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
7.0
87
460
Z02.4
ICD-10 Finland
Examination for driving licence
0.5
7.0
55
1032
AP1
HP
Catheterization of the left side of the heart
4.6
7.0
23
52
I20.01
ICD-10 Finland
Unstable angina
3.2
7.0
35
114
CKC10
NOMESCO Finland
Local photocoagulation of retina
4.3
7.0
24
57
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.3
7.0
65
303
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.2
7.0
68
326
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.0
6.9
26
67
AA1
HP
Conventional CABG
3.9
6.9
27
72
WX702
NOMESCO Finland
Supraglottic ventilation device
3.5
6.9
31
93
C07AB02
ATC
metoprolol; systemic
1.7
6.8
185
1267
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.1
6.8
35
117
ZXF00
NOMESCO Finland
Interruption caused by intraoperative deterioration of general condition
40.5
6.8
8
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
16.9
6.8
10
6
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.3
6.7
31
96
L89
ICD-10 Finland
Decubitus ulcer and pressure area
4.3
6.7
23
55
B03XA01
ATC
erythropoietin; parenteral
6.5
6.7
16
25
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
3.7
6.7
27
75
H05BX01
ATC
cinacalcet; oral
7.9
6.6
14
18
AN3
HP
Balloon angioplasty and metallic stent
3.1
6.6
34
114
J01FF01
ATC
clindamycin; systemic
1.7
6.6
143
920
R41.0
ICD-10 Finland
Disorientation, unspecified
3.0
6.6
35
120
E87.5
ICD-10 Finland
Hyperkalaemia
4.2
6.6
23
56
C09BA02
ATC
enalapril and diuretics; systemic
2.1
6.5
75
383
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
1.9
6.4
102
590
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.3
6.4
30
94
I50
ICD-10 Finland
Heart failure
2.7
6.3
42
165
H3601, E103
ICD-10 Finland
NA
11.2
6.3
11
10
B05DB
ATC
Hypertonic solutions
9.4
6.3
12
13
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
18.2
6.3
9
5
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
2.4
6.3
50
216
TK810
NOMESCO Finland
Hemofiltration
7.1
6.2
14
20
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
26.9
6.2
8
*
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
2.5
6.2
47
198
Z49.0
ICD-10 Finland
Preparatory care for dialysis
5.4
6.2
17
32
A07AA09
ATC
vancomycin; oral
5.8
6.2
16
28
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.7
6.1
40
156
UJD02
NOMESCO Finland
Gastroscopy
2.9
6.1
35
125
B05DA
ATC
Isotonic solutions
8.7
6.1
12
14
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
6.1
62
304
H02AB06
ATC
prednisolone; systemic
1.5
6.0
256
1948
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
173
448
4.89
63.63
20.1
6.5
15.0
11.7
mmol/l
4.74
167
419
186
594
3.98
50.84
14.2
6.2
5.2
5.1
kpa
1.13
171
562
185
595
3.94
49.97
14.3
6.1
10.0
11.4
kpa
4.42
169
563
195
652
3.83
49.76
18.5
5.0
1.2
1.0
mmol/l
7.63
187
597
184
595
3.91
49.24
14.4
6.2
2.4
1.4
mmol/l
1.71
137
454
190
765
3.09
34.60
5.9
3.0
0.8
0.8
mmol/l
2.31
181
706
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
81
184
4.88
33.91
4.0
2.4
0.3
0.3
u/ml
0.65
50
106
42
53
8.39
31.42
9.2
5.7
390.5
238.9
iu/ml
—
11
7
141
506
3.28
30.90
8.8
3.6
2.2
2.0
mmol/l
0.34
113
390
181
760
2.91
30.09
6.6
2.4
2.2
2.2
g/l
1.09
168
686
174
718
2.94
29.84
6.9
2.4
21.1
21.4
%
0.06
133
616
139
511
3.18
29.14
8.9
3.6
5.8
5.8
kpa
0.11
127
492
108
342
3.58
28.74
18.2
5.1
25.3
24.4
mmol/l
1.17
103
316
135
508
3.09
27.06
5.6
3.1
540.1
253.2
ng/l
4.42
123
467
182
828
2.66
25.43
6.8
2.4
10.9
11.8
umol/l
0.48
174
751
107
369
3.27
24.72
8.9
3.8
199.1
97.3
ng/l
2.51
100
316
55
121
4.87
23.77
22.7
4.7
104.6
104.9
mmol/l
0.16
49
107
200
1021
2.38
21.35
7.8
4.0
452.6
218.3
ng/l
1.00
179
876
91
322
3.12
19.98
7.2
3.1
112.2
124.2
g/l
5.32
86
314
77
252
3.33
19.21
9.6
3.8
24.4
24.0
mmol/l
0.49
69
228
79
263
3.28
19.17
11.9
9.0
24.6
24.7
mmol/l
0.04
71
241
72
230
3.39
18.66
18.3
3.8
1.9
1.6
%
3.08
62
213
134
613
2.49
17.91
2.0
1.7
—
—
—
0
0
133
618
2.44
17.13
2.2
1.7
—
—
—
0
0
103
431
2.65
16.48
6.2
3.0
5.6
4.4
kpa
4.00
92
412
96
391
2.70
16.19
2.2
1.6
—
—
—
0
0
40
93
4.51
16.13
1.6
1.6
—
—
—
0
0
67
225
3.20
15.98
3.7
1.9
8.2
3.1
ug/l
0.46
62
183
38
89
4.47
15.19
1.5
1.6
—
—
—
0
0
74
273
2.93
14.99
2.5
1.8
1.5
1.6
g/l
0.18
65
237
45
123
3.85
14.67
5.9
2.4
2.5
1.9
mg/l
2.92
40
109
96
422
2.49
13.78
13.1
6.6
1.4
1.5
mmol/l
0.34
88
401
150
798
2.14
13.76
4.0
1.9
30.8
30.1
s
0.94
144
764
18
7
26.36
13.42
7.7
7.9
—
—
—
0
0
18
7
26.36
13.42
15.3
11.4
5.6
6.8
mmol/l
—
18
7
161
892
2.07
13.22
2.4
1.8
—
—
—
0
0
122
607
2.24
13.19
6.2
3.6
262.8
246.6
u/l
0.74
116
572
30
67
4.64
12.71
1.4
1.5
—
—
—
0
0
70
274
2.74
12.68
7.3
3.3
24.4
24.9
mmol/l
0.36
65
267
45
140
3.38
12.12
3.7
2.3
7.6
7.8
kpa
0.25
45
125
295
3883
0.56
11.67
44.0
16.6
54.9
71.9
ml/min/173m2
16.50
252
3243
23
44
5.38
11.60
1.2
1.0
—
—
—
0
0
42
134
3.28
10.88
1.7
1.6
—
116.7
—
0
6
102
510
2.18
10.79
4.4
2.8
7.3
9.4
umol/l
1.09
87
451
45
156
3.02
10.16
4.1
3.1
0.9
0.9
nmol/l
0.08
37
119
96
489
2.13
9.65
3.7
2.6
6.7
5.9
ug/l
0.28
88
409
11
11
10.15
9.56
3.6
1.9
84.2
99.0
%
0.45
11
11
24
57
4.33
9.44
1.6
1.6
—
—
—
0
0
380
4578
0.59
9.38
65.4
25.4
120.8
132.1
g/l
25.85
371
4474
380
4576
0.59
9.33
65.0
25.3
4.1
4.4
e12/l
14.35
367
4420
70
328
2.27
8.63
7.0
3.6
1.6
2.0
mmol/l
0.30
54
239
23
57
4.14
8.58
1.3
1.5
—
—
—
0
0
24
62
3.98
8.48
1.4
1.5
—
—
—
0
0
27
76
3.66
8.47
1.5
1.2
—
—
—
0
0
313
3911
0.62
8.42
5.4
4.5
1.2
1.4
mmol/l
18.04
293
3496
23
58
4.07
8.39
1.6
1.1
326.1
285.1
u/ml
0.20
18
34
327
4038
0.62
8.28
5.7
4.9
6.5
6.1
mmol/l
3.40
294
3581
200
1359
1.68
8.03
3.0
2.2
3.1
3.2
mg/l
0.31
184
1137
23
60
3.93
8.02
1.6
1.2
—
—
—
0
0
334
4084
0.63
7.86
6.0
5.1
2.2
2.5
mmol/l
8.21
312
3652
370
4408
0.63
7.59
20.4
10.5
28.9
24.5
u/l
1.60
355
4209
323
3956
0.64
7.40
5.5
4.5
4.0
4.4
mmol/l
9.05
301
3569
43
175
2.56
7.23
1.8
1.3
—
—
—
0
0
239
1735
1.59
7.22
6.3
3.2
5925.3
2258.7
ng/l
5.74
216
1506
10
5
20.26
7.15
1.0
1.0
—
—
—
0
0
311
2403
1.56
7.14
26.4
6.3
1.2
1.2
mmol/l
11.45
274
1987
33
118
2.89
7.10
1.5
1.2
—
—
—
0
0
33
118
2.89
7.10
1.5
1.2
—
—
—
0
0
137
2027
0.59
6.95
3.6
5.3
2.5
3.7
ug/l
1.20
117
1783
309
3782
0.65
6.67
5.1
4.1
1.5
1.2
mmol/l
6.17
287
3356
140
904
1.70
6.67
3.6
1.7
1.8
1.4
mg/l
0.74
116
722
285
2184
1.54
6.64
22.6
5.6
1.2
1.2
mmol/l
10.20
266
1932
35
137
2.64
6.38
1.9
1.5
—
—
—
0
0
245
1831
1.54
6.33
6.5
2.7
244.1
156.7
ug/l
2.18
234
1643
380
4436
0.66
6.29
63.4
21.0
4.1
4.0
mmol/l
3.61
370
4301
42
181
2.41
6.28
3.3
3.4
69.9
35.1
mg/l
2.25
35
147
380
4430
0.66
6.17
61.5
20.9
138.9
139.5
mmol/l
4.27
369
4292
82
463
1.88
6.12
2.9
2.6
64.9
65.6
g/l
0.30
76
406
23
73
3.23
6.06
1.5
1.6
—
—
—
0
0
12
23
5.29
6.02
1.1
1.1
—
—
—
0
0
188
1339
1.57
5.96
4.5
2.9
39.6
33.6
u/l
0.25
178
1280
41
180
2.36
5.90
3.4
3.4
95.6
98.4
mg/l
0.03
34
144
21
64
3.35
5.90
1.3
1.2
—
—
—
0
0
106
1615
0.59
5.82
3.5
4.7
23.2
21.6
%
0.46
52
822
77
434
1.88
5.78
2.9
2.1
0.2
0.2
g/l
0.20
72
392
23
77
3.06
5.57
1.3
1.2
—
—
—
0
0
17
48
3.61
5.35
1.4
1.6
—
—
—
0
0
70
393
1.87
5.32
3.2
2.5
34.7
32.4
u/l
0.24
60
327
34
144
2.43
5.31
1.6
2.0
32.6
38.8
u/l
0.81
29
125
68
1141
0.55
5.27
2.3
3.2
1.1
0.8
ug/l
0.54
48
784
272
2139
1.46
5.24
14.0
4.5
31.6
34.4
g/l
12.29
263
1963
14
35
4.06
5.18
1.4
1.1
51.8
53.0
u/l
—
9
23
41
194
2.19
4.99
1.6
2.3
3.4
3.2
g/l
0.55
28
146
43
210
2.12
4.84
1.6
2.3
4.4
3.7
g/l
1.23
28
143
43
211
2.11
4.79
1.6
2.3
8.0
7.5
g/l
0.73
29
148
43
211
2.11
4.79
1.6
2.3
—
—
—
0
0
10
21
4.82
4.54
1.1
1.3
—
—
—
0
0
40
196
2.11
4.48
1.7
2.3
10.9
10.2
g/l
0.51
30
161
323
3780
0.71
4.42
5.4
4.4
2.2
2.0
mu/l
1.75
298
3324
372
4249
0.71
4.37
48.0
17.5
31.8
27.4
mg/l
1.75
352
3529
165
1222
1.47
4.17
4.8
2.7
7617.8
7443.8
umol/l
0.01
153
1031
9
13
7.00
4.17
1.1
1.2
—
—
—
0
0
291
2406
1.38
3.89
9.7
5.8
13.1
12.2
umol/l
0.49
281
2269
188
1445
1.42
3.86
4.8
2.4
61.2
57.6
u/l
0.19
181
1339
36
180
2.06
3.85
2.8
2.8
—
—
—
0
0
341
3908
0.73
3.76
10.3
6.4
45.6
41.2
mmol/mol
7.81
319
3546
56
328
1.77
3.76
2.1
1.5
—
—
—
0
0
21
84
2.55
3.74
1.3
1.3
483.2
1451.7
e6/l
2.21
16
60
11
30
3.71
3.65
1.3
1.6
—
—
—
0
0
27
540
0.48
3.60
6.2
4.6
31.6
32.6
%
0.21
21
346
16
59
2.75
3.34
1.3
1.5
—
—
—
0
0
18
71
2.58
3.31
1.3
1.3
27287.1
30006.9
e6/l
0.06
12
44
25
119
2.14
3.07
1.7
1.3
—
—
—
0
0
182
1440
1.36
3.07
5.9
3.9
43.7
10.2
mg/mmol
4.09
144
915
174
1376
1.36
2.93
5.1
3.1
6.4
7.1
mmol/l
1.63
156
1115
10
31
3.26
2.78
1.2
1.4
—
—
—
0
0
14
54
2.63
2.71
2.9
2.6
—
—
—
0
0
108
799
1.42
2.70
38.5
29.6
1.6
1.5
inr
0.23
15
100
31
169
1.87
2.67
1.8
2.4
34.5
36.6
g/l
1.20
26
136
9
25
3.63
2.58
3.2
1.7
—
—
—
0
0
108
808
1.40
2.53
5.2
3.2
2.5
2.3
e6/l
0.10
67
463
23
115
2.04
2.53
1.9
1.6
—
—
—
0
0
10
33
3.06
2.53
1.8
1.7
—
—
—
0
0
281
2424
1.28
2.45
13.5
8.2
4.9
4.4
e9/l
3.47
252
2110
11
40
2.78
2.38
1.3
1.7
—
—
—
0
0
12
46
2.64
2.36
1.6
2.7
—
—
—
0
0
15
65
2.34
2.32
1.2
1.1
—
—
—
0
0
180
1475
1.30
2.32
3.0
2.0
210.3
297.1
u/l
0.73
169
1373
10
35
2.88
2.31
1.9
1.6
—
—
—
0
0
35
561
0.60
2.27
16.2
8.8
—
—
—
0
0
76
546
1.44
2.24
5.6
4.0
—
—
—
0
0
109
836
1.36
2.21
4.1
3.0
1.2
1.2
e6/l
0.04
68
485
11
42
2.65
2.19
1.2
1.1
—
—
—
0
0
9
31
2.93
2.07
1.2
1.4
—
—
—
0
0
314
2786
1.24
2.04
16.4
4.6
8.1
6.9
mmol/l
9.67
300
2614
17
83
2.07
2.02
1.7
1.3
—
—
—
0
0
49
330
1.52
2.00
5.4
3.1
37.9
57.8
ml/min/173m2
3.57
27
149
236
2040
1.24
1.92
8.9
4.3
—
—
—
0
0
210
1798
1.25
1.85
6.2
3.4
—
—
—
0
0
18
325
0.54
1.84
2.6
2.1
12.4
12.2
nmol/l
0.03
18
281
13
60
2.19
1.78
1.6
1.5
—
—
—
0
0
6
18
3.35
1.75
1.5
1.1
65.3
102.8
u/l
—
6
12
331
3628
0.82
1.74
48.8
18.9
35.4
38.5
%
4.66
189
2272
7
24
2.93
1.72
1.4
1.7
—
—
—
0
0
16
82
1.97
1.70
1.3
1.1
48.9
48.1
u/l
0.01
11
66
7
163
0.42
1.68
1.1
1.0
—
—
—
0
0
7
25
2.82
1.65
1.4
1.7
—
—
—
0
0
166
1407
1.24
1.58
5.5
3.3
0.9
0.6
e6/l
0.55
142
1084
11
50
2.22
1.57
1.3
1.1
2.5
7.5
u/ml
—
6
24
132
1093
1.26
1.54
5.4
2.5
—
—
—
0
0
274
3036
0.83
1.54
4.6
3.6
15.0
15.1
pmol/l
0.15
259
2641
8
33
2.44
1.54
1.5
1.7
—
—
—
0
0
5
15
3.35
1.52
1.4
1.3
—
—
—
0
0
181
1555
1.23
1.52
6.4
3.5
115.8
126.2
e6/l
0.05
158
1226
13
65
2.02
1.49
5.6
1.8
31.4
33.0
pg
0.65
13
65
6
23
2.62
1.37
1.2
2.1
—
—
—
0
0
8
34
2.37
1.29
1.8
1.7
—
—
—
0
0
8
34
2.37
1.29
1.8
1.7
—
—
—
0
0
8
34
2.37
1.29
1.8
1.7
—
—
—
0
0
5
18
2.79
1.28
1.2
1.2
11.2
25.8
%
—
5
10
47
346
1.39
1.28
2.0
1.6
—
—
—
0
0
16
93
1.74
1.22
1.6
1.5
—
—
—
0
0
6
26
2.32
1.19
1.0
1.0
—
—
—
0
0
0
35
0.00
1.15
0.0
3.5
—
—
—
0
0
102
1207
0.82
1.11
7.0
4.5
0.0
0.0
estimate
0.50
27
385
7
31
2.27
1.10
2.3
2.6
—
—
—
0
0
7
31
2.27
1.10
1.1
1.1
—
—
—
0
0
8
41
1.96
1.09
17.4
2.9
428.8
339.4
umol/l
—
8
36
7
33
2.13
1.05
1.4
1.6
—
—
—
0
0
5
22
2.28
1.03
4.4
2.7
—
—
—
0
0
5
22
2.28
1.03
4.4
2.7
—
—
—
0
0
228
2496
0.87
0.99
5.2
3.1
70.8
56.6
u/l
1.48
215
2283
9
49
1.85
0.99
2.3
1.4
—
—
—
0
0
9
49
1.85
0.99
2.4
1.4
—
—
—
0
0
0
32
0.00
0.95
0.0
1.5
—
—
—
0
0
0
32
0.00
0.95
0.0
1.5
—
—
—
0
0
0
32
0.00
0.95
0.0
1.5
—
—
—
0
0
11
62
1.79
0.94
2.7
2.0
87.7
89.7
%
0.51
11
62
22
153
1.45
0.86
2.1
1.5
—
—
—
0
0
8
47
1.71
0.81
2.6
1.4
—
—
—
0
0
152
1689
0.87
0.80
6.4
4.6
—
—
—
0
0
12
74
1.63
0.78
1.1
1.1
—
—
—
0
0
133
1181
1.16
0.77
2.0
1.8
1325.7
1179.3
nmol/l
0.75
112
881
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
63
746
0.83
0.72
1.3
1.2
0.9
1.3
u/ml
0.63
12
190
299
3164
0.90
0.69
5.3
4.0
23.0
14.8
mm/h
8.52
277
2857
5
27
1.86
0.68
1.4
1.4
—
—
—
0
0
5
27
1.86
0.68
1.2
1.1
—
—
—
0
0
7
44
1.60
0.65
1.1
1.1
1.9
1.6
g/l
—
7
39
5
29
1.73
0.64
2.4
1.6
—
—
—
0
0
5
29
1.73
0.64
2.4
1.6
—
—
—
0
0
12
176
0.68
0.63
1.1
1.9
—
—
—
0
0
8
49
1.64
0.62
2.5
1.4
—
—
—
0
0
8
49
1.64
0.62
2.5
1.4
—
—
—
0
0
8
50
1.61
0.61
2.5
1.4
—
—
—
0
0
8
50
1.61
0.61
1.6
1.3
17.9
25.9
iu/l
—
8
43
6
36
1.67
0.56
1.5
1.1
—
—
—
0
0
22
172
1.29
0.48
1.2
1.2
93.9
135.6
iu/ml
—
7
59
92
1019
0.89
0.48
4.0
3.2
2.5
2.5
mmol/l
0.54
76
869
36
428
0.83
0.47
1.4
1.4
—
—
—
0
0
7
48
1.46
0.47
3.9
3.9
—
—
—
0
0
192
2037
0.92
0.44
3.2
2.5
—
—
—
0
0
7
51
1.38
0.44
1.3
1.3
—
—
—
0
0
320
3323
0.93
0.43
56.1
21.2
15.0
14.0
%
19.09
310
3250
5
31
1.62
0.43
1.2
1.1
—
—
—
0
0
12
162
0.74
0.43
1.0
1.7
—
—
—
0
0
6
94
0.63
0.42
4.3
3.9
17.2
425.7
u/ml
—
6
86
139
1291
1.10
0.41
1.8
1.6
18.5
20.1
nmol/l
0.55
124
1087
5
33
1.52
0.41
1.2
1.1
—
—
—
0
0
26
314
0.82
0.41
1.4
1.3
—
—
—
0
0
183
1725
1.08
0.39
3.8
2.2
72.6
78.4
nmol/l
2.05
168
1490
17
134
1.28
0.37
1.1
1.2
—
—
—
0
0
6
44
1.37
0.34
1.8
2.4
434.0
564.5
ml
—
6
25
17
136
1.26
0.33
1.1
1.2
—
—
—
0
0
6
87
0.69
0.33
1.3
1.6
52.8
46.0
nmol/l
—
6
81
6
46
1.31
0.33
1.0
1.3
—
—
—
0
0
205
2142
0.94
0.31
7.7
5.8
0.0
0.0
estimate
0.00
37
398
208
2169
0.94
0.30
5.7
4.3
0.0
0.0
estimate
0.00
34
397
94
1008
0.92
0.29
2.4
1.6
1.7
1.3
mmol/l
2.61
89
822
172
1638
1.07
0.29
5.4
3.2
2.3
2.3
mmol/l
1.61
158
1387
15
121
1.24
0.28
1.1
1.4
—
—
—
0
0
11
85
1.30
0.28
1.3
1.2
—
28.5
—
0
5
16
132
1.22
0.25
1.9
2.4
394.6
92.6
ug/min
—
9
76
24
207
1.16
0.25
11.0
4.2
24.8
25.0
mmol/l
0.09
24
195
12
96
1.25
0.24
1.7
1.5
—
—
—
0
0
103
970
1.07
0.24
5.7
4.8
1.0
1.0
kg/l
0.19
19
162
215
2074
1.05
0.24
2.4
2.1
91.4
91.8
pmol/l
0.04
122
1106
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
10
123
0.81
0.20
6.2
4.2
21.0
31.2
mg/l
—
10
83
0
14
0.00
0.20
0.0
1.7
—
1.2
—
0
14
314
3076
1.04
0.17
6.9
5.1
9215.8
2421.9
e6/l
—
6
71
8
71
1.13
0.16
1.3
1.4
—
—
—
0
0
209
2141
0.96
0.15
5.6
4.2
0.0
0.0
estimate
0.00
37
409
20
180
1.11
0.13
1.2
1.3
—
—
—
0
0
118
1147
1.03
0.10
1.9
1.8
444.1
10532470.5
pmol/l
0.79
108
921
6
57
1.05
0.08
2.0
1.3
—
—
—
0
0
5
61
0.82
0.08
1.2
1.9
—
—
—
0
0
5
61
0.82
0.08
1.2
1.5
—
—
—
0
0
6
74
0.81
0.07
1.2
2.1
—
—
—
0
0
340
3428
0.98
0.07
14.8
7.2
95.1
82.0
u/l
1.03
324
3184
10
89
1.12
0.06
1.5
1.6
—
—
—
0
0
51
525
0.97
0.05
1.3
1.2
7.9
8.9
u/ml
0.08
23
186
52
535
0.97
0.05
4.0
4.1
4.6
31.2
ug/l
1.14
45
455
206
2037
1.02
0.05
8.2
4.2
141.8
68.3
ng/l
0.81
160
1577
21
199
1.06
0.04
3.6
1.7
—
—
—
0
0
54
553
0.97
0.04
1.3
1.2
150.8
39.0
iu/ml
0.67
21
178
10
100
1.00
0.00
1.1
1.3
—
—
—
0
0
22
222
0.99
0.00
3.6
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
7
73
0.96
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint J10_PULMOEDEMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMOEDEMA | 3.634 [3.06, 4.32] | < 0.001 |
| Birth year | 0.996 [0.99, 1.01] | 0.435 |
During the follow-up period (1.1.1998 — 31.12.2019), 1992 out of 2704 females with J10_PULMOEDEMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMOEDEMA | 4.391 [3.53, 5.47] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 1713 out of 2356 males with J10_PULMOEDEMA died.
Mortality risk
Mortality risk for people of age
years, who have J10_PULMOEDEMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.404% | 0.926% |
| 5 | 2.256% | 4.818% |
| 10 | 5.214% | 12.463% |
| 15 | 10.119% | 22.504% |
| 20 | 17.492% | 35.623% |
Relationships between endpoints
↥Index endpoint: J10_PULMOEDEMA – Pulmonary oedema
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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