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Injury of cranial nerves

ST19_INJURY_CRANIAL_NERVES

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 S04
  • Cause of death: ICD-10 S04

2 out of 7 registries used, show all original rules.

231

4. Check minimum number of events

None

231

5. Include endpoints

None

231

6. Filter based on genotype QC (FinnGen only)

231

Control definitions (FinnGen only)

Control exclude
ST19_INJURI_HEAD

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S0
Name in latin
Laesiones nervorum cranialium

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 231 121 110
Unadjusted period prevalence (%) 0.04 0.04 0.05
Median age at first event (years) 51.57 50.32 52.95

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
210
Matched controls
2099
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
S04.3
ICD-10 Finland
Injury of trigeminal nerve
+∞
61.5
56
*
S04.5
ICD-10 Finland
Injury of facial nerve
+∞
36.5
34
*
S04.0
ICD-10 Finland
Injury of optic nerve and pathways
+∞
33.2
31
*
S04.7
ICD-10 Finland
Injury of accessory nerve
+∞
25.5
24
*
S04.1
ICD-10 Finland
Injury of oculomotor nerve
+∞
24.4
23
*
S06.3
ICD-10 Finland
Focal brain injury
+∞
20.1
19
*
S06.0
ICD-10 Finland
Concussion
29.8
18.3
24
9
AA1AD
NOMESCO Finland
CT of head and brain
4.7
17.4
68
195
T90.5
ICD-10 Finland
Sequelae of intracranial injury
51.9
16.3
19
*
S06.2
ICD-10 Finland
Diffuse brain injury
+∞
15.8
15
*
S02.40
ICD-10 Finland
Fracture of malar and maxillary bones, closed
149.2
13.6
14
*
S02.30
ICD-10 Finland
Fracture of orbital floor, closed
+∞
12.6
12
*
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
+∞
12.6
12
*
G50.8
ICD-10 Finland
Other disorders of trigeminal nerve
137.8
12.6
13
*
NA1AD
NOMESCO Finland
Cervical spine CT examination
15.9
12.0
19
13
N03AX12
ATC
gabapentin; oral
4.0
11.5
50
153
N03AX16
ATC
pregabalin; oral
3.2
10.7
67
270
S04.4
ICD-10 Finland
Injury of abducent nerve
+∞
10.5
10
*
S04.9
ICD-10 Finland
Injury of unspecified cranial nerve
+∞
10.5
10
*
S04.2
ICD-10 Finland
Injury of trochlear nerve
+∞
10.5
10
*
R51.80
ICD-10 Finland
Headache
3.9
10.4
45
136
X58
ICD-10 Finland
Exposure to other specified factors
3.6
10.2
50
169
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.2
10.1
40
112
G50.1
ICD-10 Finland
Atypical facial pain
21.3
9.9
14
7
X59
ICD-10 Finland
Exposure to unspecified factor
3.3
9.5
53
197
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.8
9.2
40
121
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
9.7
9.2
18
20
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
9.2
73
340
W19
ICD-10 Finland
Unspecified fall
5.0
8.6
27
60
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.8
8.5
64
285
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
+∞
8.4
8
*
S02.11
ICD-10 Finland
Fracture of base of skull, open
+∞
8.4
8
*
G51.0
ICD-10 Finland
Bell palsy
8.7
8.3
17
21
H53.2
ICD-10 Finland
Diplopia
10.7
8.2
15
15
P15
ICPC
Chronic alcohol abuse
9.4
7.7
15
17
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
26.1
7.6
10
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
7.6
94
544
SAA03
NOMESCO Finland
Extended examination of mouth
2.3
7.6
94
545
T88.8
ICD-10 Finland
Other specified complications of surgical and medical care, not elsewhere classified
82.9
7.5
8
*
S00.8
ICD-10 Finland
Superficial injury of other parts of head
82.9
7.5
8
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
7.8
7.3
16
22
S04.88
ICD-10 Finland
Injury of other cranial nerves
+∞
7.3
7
*
S02.20
ICD-10 Finland
Fracture of nasal bones, closed
+∞
7.3
7
*
A02BC05
ATC
esomeprazole; systemic
2.2
7.1
97
582
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.3
7.1
82
455
N06AA10
ATC
nortriptyline; systemic
9.8
6.9
13
14
R42
ICD-10 Finland
Dizziness and giddiness
2.7
6.8
48
205
SHA04
NOMESCO Finland
Correction of physiology of bite - very demanding therapy visit
23.4
6.7
9
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
6.7
97
593
N05BA04
ATC
oxazepam; oral
2.5
6.7
59
284
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
4.4
6.6
23
57
N02BE01
ATC
paracetamol; systemic, rectal
2.7
6.6
183
1496
K07.60
ICD-10 Finland
Snapping jaw
5.0
6.6
20
43
L01
ICPC
Neck symptom/complaint
3.1
6.6
37
136
R07.3
ICD-10 Finland
Other chest pain
3.9
6.6
26
73
N05AH04
ATC
quetiapine; oral
2.9
6.6
41
162
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.7
6.6
28
84
ZXE20
NOMESCO Finland
More than three and less than five hours
2.9
6.5
40
155
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.8
6.5
27
79
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
5.9
6.5
17
31
AAA27
NOMESCO Finland
Insertion of intracerebral pressure monitoring device
+∞
6.3
6
*
S02.71
ICD-10 Finland
Multiple fractures involving skull and facial bones, open
+∞
6.3
6
*
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
+∞
6.3
6
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
27.6
6.3
8
*
Y60
ICD-10 Finland
Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care
27.6
6.3
8
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.7
6.2
20
46
ZXA05
NOMESCO Finland
Left side
2.4
6.1
56
273
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.3
6.0
30
102

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ST19_INJURY_CRANIAL_NERVES – Injury of cranial nerves

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).