No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
340 |
4. Check minimum number of eventsNone |
340 |
5. Include endpointsNone |
340 |
6. Filter based on genotype QC (FinnGen only) |
331 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amaurosis unius oculi
Similar endpoints
↥List of similar endpoints to
Blindness, monocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2797 | 1353 | 1421 |
| Only index persons | 2501 | 1233 | 1268 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 68.28 | 72.20 | 64.44 |
| Only index persons | 67.17 | 71.56 | 62.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 331 | 172 | 159 |
| Unadjusted period prevalence (%) | 0.07 | 0.06 | 0.07 |
| Median age at first event (years) | 66.62 | 63.88 | 69.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 340
- Matched controls
- 3400
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.4
ICD-10 Finland
Blindness, monocular
+∞
307.7
339
*
S01ED51
ATC
timolol, combinations; ophthalmic
9.3
72.0
105
156
XCK00
NOMESCO Finland
Perimetry
10.3
65.3
83
103
114
Kela drug reimbursment
Glaucoma
7.9
64.7
110
193
S01EC01
ATC
acetazolamide; systemic
17.9
61.0
52
34
S01ED01
ATC
timolol; ophthalmic
12.5
60.7
65
63
H53.1
ICD-10 Finland
Subjective visual disturbances
25.1
60.6
44
20
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.1
54.2
99
185
H43.1
ICD-10 Finland
Vitreous haemorrhage
16.7
50.3
44
30
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
72.5
49.0
55
9
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
8.7
46.2
65
90
H33.0
ICD-10 Finland
Retinal detachment with retinal break
12.0
45.7
49
47
S01EA05
ATC
brimonidine; ophthalmic
13.5
45.5
45
38
H34.8
ICD-10 Finland
Other retinal vascular occlusions
15.2
41.4
38
28
S01EE01
ATC
latanoprost; ophthalmic
7.0
41.2
71
123
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.7
40.7
63
97
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.6
37.7
123
374
H16.0
ICD-10 Finland
Corneal ulcer
8.0
33.6
49
70
S01EC04
ATC
brinzolamide; ophthalmic
7.8
32.7
49
72
XCK10
NOMESCO Finland
Photography of fundus of eye
4.9
30.1
79
199
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.0
29.4
108
351
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.6
29.3
211
1061
CKC12
NOMESCO Finland
Photocoagulation of retina
8.0
29.1
42
59
WX140
NOMESCO Finland
Parabulbar anesthesy
6.6
28.3
49
84
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
9.8
27.3
33
37
H53.4
ICD-10 Finland
Visual field defects
152.1
27.0
28
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.7
26.0
69
174
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
93.6
24.0
26
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.1
23.7
186
948
H34.1
ICD-10 Finland
Central retinal artery occlusion
58.4
23.4
27
5
AA1AD
NOMESCO Finland
CT of head and brain
3.2
23.4
139
603
S01EX03, ,
ATC
9.8
23.3
28
31
CS494
NOMESCO Finland
Other visual field testing
10.0
22.9
27
29
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
51.4
20.4
24
5
H44.5
ICD-10 Finland
Degenerated conditions of globe
111.6
19.8
21
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
8.2
18.9
26
34
H54.0
ICD-10 Finland
Blindness, binocular
+∞
18.9
18
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
14.7
18.6
31
23
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
5.0
18.6
43
96
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
17.9
17
*
H47.2
ICD-10 Finland
Optic atrophy
+∞
17.9
17
*
S01BA01
ATC
dexamethasone; ophthalmic
6.5
17.1
29
48
CKD15
NOMESCO Finland
Injection of vitreous substitute
37.2
16.9
21
6
S01EC03
ATC
dorzolamide; ophthalmic
17.5
16.8
26
16
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
5.6
16.6
33
64
S01FA01
ATC
atropine; ophthalmic
40.1
15.5
19
5
Z3229
NOMESCO Finland
Other healthcare associate professional
3.6
15.4
56
175
S01EE05
ATC
tafluprost; ophthalmic
5.7
14.9
29
55
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
14.8
187
1128
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
23.5
14.4
20
9
S01EC54
ATC
brinzolamide, combinations; ophthalmic
16.7
14.1
22
14
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
5.4
14.1
29
58
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.4
14.1
162
932
S01EE04
ATC
travoprost; ophthalmic
6.8
13.8
22
34
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.4
13.6
55
184
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
145.6
13.5
14
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.9
13.5
72
284
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.0
13.0
40
111
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.7
13.0
25
47
G45.3
ICD-10 Finland
Amaurosis fugax
10.3
13.0
25
26
H27.0
ICD-10 Finland
Aphakia
52.1
12.9
15
*
H26.4
ICD-10 Finland
After-cataract
3.1
12.9
60
218
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
10.7
12.7
24
24
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
72.6
12.7
14
*
A10AA01, ,
ATC
5.9
12.6
23
41
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
25.5
12.6
17
7
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
+∞
12.6
12
*
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
+∞
12.6
12
*
ZXA05
NOMESCO Finland
Left side
2.4
12.5
117
607
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.8
12.1
68
275
H26.2
ICD-10 Finland
Complicated cataract
15.4
11.9
19
13
A10AA02, ,
ATC
4.9
11.9
27
59
H40.0
ICD-10 Finland
Glaucoma suspect
3.6
11.8
42
129
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.6
11.8
41
124
H3603, E103,
ICD-10 Finland
31.3
11.7
15
5
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
19.8
11.7
17
9
H53.9
ICD-10 Finland
Visual disturbance, unspecified
10.6
11.7
22
22
H46
ICD-10 Finland
Optic neuritis
23.9
11.7
16
7
SPAT1360
SPAT
Extensive global examination
3.8
11.7
37
105
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.0
11.6
58
220
S01EA03
ATC
apraclonidine; ophthalmic
15.8
11.4
18
12
H57.1
ICD-10 Finland
Ocular pain
5.0
11.4
25
53
H54.5
ICD-10 Finland
Severe visual impairment, monocular
26.0
11.2
15
6
A10AB01
ATC
insulin (human); parenteral
4.6
11.2
27
62
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
10.1
10.9
21
22
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
62.0
10.7
12
*
Z97.0
ICD-10 Finland
Presence of artificial eye
62.0
10.7
12
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
4.0
10.6
31
83
CDC40
NOMESCO Finland
Evisceration of eye with insertion of prosthesis
+∞
10.5
10
*
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
16.7
10.4
16
10
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
24.2
10.3
14
6
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
8.3
10.3
22
28
CKD20
NOMESCO Finland
Removal of vitreous body substitute
15.2
10.1
16
11
H18.1
ICD-10 Finland
Bullous keratopathy
41.4
10.0
12
*
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.9
9.9
30
82
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
9.8
101
539
A10AE04
ATC
insulin glargine; parenteral
2.9
9.7
50
192
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.7
9.6
32
94
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.4
9.5
35
110
A10AC01
ATC
insulin (human); parenteral
3.0
9.5
45
165
CDC00
NOMESCO Finland
Enucleation of eye
102.8
9.5
10
*
H25.2
ICD-10 Finland
Senile cataract, morgagnian type
31.0
9.5
12
*
H34.2
ICD-10 Finland
Other retinal artery occlusions
22.4
9.4
13
6
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
9.4
9
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
+∞
9.4
9
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
9.4
9
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
14.2
9.3
15
11
XCH00
NOMESCO Finland
Eye pressure measurement
4.0
9.3
27
72
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.7
9.0
29
83
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
19.2
9.0
13
7
Z94.0
ICD-10 Finland
Kidney transplant status
24.8
9.0
12
5
TCG10
NOMESCO Finland
Removal of sutures from cornea
24.8
9.0
12
5
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.5
8.8
22
52
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
14.5
8.8
14
10
ZXD05
NOMESCO Finland
Urgent procedure
2.1
8.7
117
687
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.5
8.7
59
260
H50.1
ICD-10 Finland
Divergent concomitant strabismus
51.3
8.7
10
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
4.8
8.7
20
44
A12AA04
ATC
calcium carbonate; oral
12.0
8.7
15
13
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
12.0
8.7
15
13
B01AC04
ATC
clopidogrel; oral
2.3
8.5
75
372
37520
ICD-8 Finland
Glaucoma, Secondary
92.3
8.5
9
*
A10AB05
ATC
insulin aspart; parenteral
2.9
8.4
41
152
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
8.3
82
426
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
8.3
65
306
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.9
8.3
18
24
C10AA01
ATC
simvastatin; oral
1.9
8.1
164
1105
S01ED02
ATC
betaxolol; ophthalmic
9.3
8.1
16
18
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.5
8.1
28
84
Z94.7
ICD-10 Finland
Corneal transplant status
34.2
8.1
10
*
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
34.2
8.1
10
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
8.1
70
345
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.9
8.0
40
151
N03AX14
ATC
levetiracetam; systemic
7.2
7.9
18
26
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
15.5
7.8
12
8
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
46.1
7.7
9
*
H18.4
ICD-10 Finland
Corneal degeneration
46.1
7.7
9
*
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
7.0
7.7
18
27
S01AX11
ATC
[U] ofloxacin
3.7
7.6
24
68
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.1
7.5
92
519
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.9
7.5
22
59
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
81.8
7.4
8
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
13.8
7.4
12
9
N02BE01
ATC
paracetamol; systemic, rectal
2.6
7.4
304
2589
SPAT1234
SPAT
Support of social functional capacity
3.4
7.4
27
84
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
4.0
7.4
21
55
3690A
ICD-9 Finland
Blindness and low vision, Profound impairment, both eyes
+∞
7.3
7
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.9
7.3
36
135
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.0
7.2
33
118
L28
ICPC
Limited function/disability (L)
2.1
7.2
76
404
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
30.7
7.2
9
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
30.7
7.2
9
*
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
30.7
7.2
9
*
N02AA05
ATC
oxycodone; systemic
2.1
7.1
82
451
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.5
7.1
25
76
S01EB01
ATC
pilocarpine; ophthalmic
10.3
7.1
13
13
ZXA00
NOMESCO Finland
Right side
1.9
7.1
108
657
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.1
7.0
18
31
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.9
7.0
34
126
A28
ICPC
Limited function/disability NOS
2.1
7.0
80
439
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
6.9
6.9
16
24
A11CC03
ATC
alfacalcidol; systemic
6.9
6.9
16
24
SPAT1229
SPAT
Assessment of need for aid
2.8
6.9
36
139
B03XA02
ATC
darbepoetin alfa; parenteral
6.3
6.9
17
28
SPAT1301
SPAT
No procedures
1.9
6.9
117
737
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
6.8
52
241
CKC15
NOMESCO Finland
Panretinal photocoagulation
11.3
6.8
12
11
H04.10
ICD-10 Finland
Dry eye syndrome
2.5
6.8
47
208
S01EE03
ATC
bimatoprost; ophthalmic
4.4
6.8
17
40
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
17.1
6.8
10
6
N18.0
ICD-10 Finland
End-stage renal disease
17.1
6.8
10
6
CHC05
NOMESCO Finland
Iridotomy
7.4
6.8
15
21
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
6.8
219
1679
A10AB04
ATC
insulin lispro; parenteral
4.2
6.7
18
45
H40.9
ICD-10 Finland
Glaucoma, unspecified
5.7
6.7
18
33
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.1
6.7
78
430
V03AE01
ATC
polystyrene sulfonate; oral
9.0
6.6
13
15
127
Kela drug reimbursment
Transplant complication
10.3
6.6
12
12
C03CA01
ATC
furosemide; systemic
1.8
6.5
130
859
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.4
6.4
47
214
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
4.2
6.4
17
42
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
2.0
6.4
75
415
L04AA06
ATC
mycophenolic acid; systemic
9.5
6.3
12
13
R51.80
ICD-10 Finland
Headache
2.2
6.3
58
291
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
18.4
6.3
9
5
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
18.4
6.3
9
5
CKC20
NOMESCO Finland
Cryopexy of undetached retina
18.4
6.3
9
5
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.8
6.3
19
52
3711
FHL
Cyclodiateria or cryocoagulation
+∞
6.3
6
*
CDC30
NOMESCO Finland
Evisceration of eye
+∞
6.3
6
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
27.2
6.3
8
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
27.2
6.3
8
*
CKC70
NOMESCO Finland
Circular buckling of sclera
27.2
6.3
8
*
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.1
6.2
64
336
XCD20
NOMESCO Finland
Photoangiography of eye
5.9
6.2
16
28
H16.9
ICD-10 Finland
Keratitis, unspecified
7.9
6.2
13
17
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.3
6.2
52
252
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.0
6.2
28
100
H54.7
ICD-10 Finland
Unspecified visual loss
12.8
6.1
10
8
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
12.8
6.1
10
8
T89
ICPC
Diabetes insulin dependent
3.5
6.1
21
63
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
6.9
6.1
14
21
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.7
6.1
33
130
L04AA01
ATC
[U] ciclosporin
10.3
6.1
11
11
A04
ICPC
Weakness/tiredness general
2.1
6.1
59
303
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.2
6.0
24
79
Z02.7
ICD-10 Finland
Issue of medical certificate
2.8
6.0
30
113
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
77
219
4.25
24.83
11.3
6.2
12.52
10.15
mmol/l
1.50
71
208
156
805
2.73
18.13
2.9
2.1
260.01
214.60
u/l
0.30
147
759
233
1555
2.58
14.78
7.9
4.9
7.39
6.75
mmol/l
3.14
221
1443
204
1281
2.48
14.78
19.9
16.0
1.33
1.29
inr
0.20
45
375
80
326
2.90
14.17
11.6
5.1
1.13
1.04
mmol/l
1.29
73
296
191
1187
2.39
13.84
13.4
6.2
1.20
1.21
mmol/l
1.18
173
1088
126
670
2.40
12.81
2.6
2.1
3.59
3.29
mg/l
0.54
101
584
176
1089
2.28
12.46
5.7
3.9
31.89
42.00
ng/l
0.83
146
788
48
158
3.37
12.14
6.4
3.4
2.67
1.37
mmol/l
1.45
35
121
36
99
3.95
11.85
2.3
1.8
—
—
—
0
0
61
241
2.87
11.28
2.4
2.5
4.63
6.98
ug/l
0.62
46
212
144
849
2.21
11.15
3.8
3.4
3891.21
1534.12
ng/l
0.83
124
730
188
1233
2.17
11.08
7.2
5.8
25.74
26.93
%
0.67
178
1163
37
111
3.62
10.75
2.7
1.9
—
—
—
0
0
195
1308
2.15
10.72
15.1
6.8
1.20
1.22
mmol/l
1.69
173
1124
38
119
3.47
10.35
1.8
2.4
1.68
1.52
g/l
0.29
27
107
84
409
2.40
10.11
3.1
3.6
0.80
0.82
mmol/l
0.53
79
384
182
1213
2.08
9.90
7.0
5.6
58.83
57.98
%
0.38
173
1147
101
548
2.20
9.34
2.0
1.8
1300.90
1221.56
nmol/l
0.30
77
414
172
1143
2.02
9.22
6.7
4.4
34.72
35.21
g/l
0.54
153
1065
16
15
11.13
8.88
1.2
1.3
—
—
—
0
0
51
214
2.63
8.32
3.2
2.7
64.09
66.46
g/l
1.31
41
191
74
369
2.29
8.31
4.5
2.2
18.86
22.07
%
1.82
59
319
163
1091
1.95
8.29
3.9
2.6
162.89
128.54
ug/l
1.16
146
997
87
467
2.16
8.14
2.3
1.9
—
—
—
0
0
26
74
3.72
8.14
1.7
1.8
—
—
—
0
0
208
1517
1.96
8.13
11.1
8.8
4.26
4.21
e9/l
0.11
187
1342
66
316
2.35
8.13
10.9
7.8
—
—
—
0
0
76
389
2.23
7.99
4.4
2.1
2.25
2.34
g/l
0.62
68
352
42
163
2.80
7.96
1.6
1.4
—
—
—
0
0
16
19
8.78
7.90
1.0
1.2
—
—
—
0
0
257
2037
2.07
7.67
10.0
7.1
78.56
78.52
u/l
0.00
242
1896
248
1953
2.00
7.37
5.0
4.0
17.37
12.68
mm/h
2.94
225
1794
305
2604
2.66
7.37
26.0
15.1
22.91
23.67
mg/l
0.16
255
2076
169
1182
1.85
7.20
3.7
2.7
—
—
—
0
0
147
987
1.86
7.11
5.2
3.0
—
—
—
0
0
54
251
2.37
7.07
9.9
3.2
1.19
2.29
mmol/l
1.99
47
197
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
24
72
3.51
6.97
2.6
3.1
0.43
0.32
u/ml
0.51
15
42
61
302
2.24
6.90
8.5
9.0
4.99
5.07
kpa
0.32
56
290
131
856
1.86
6.85
2.6
2.5
82.61
61.07
u/l
0.26
121
794
13
14
9.60
6.84
1.3
1.7
—
—
—
0
0
309
2679
2.68
6.77
32.7
17.6
139.24
139.64
mmol/l
1.42
298
2609
101
608
1.94
6.77
3.7
2.4
—
—
—
0
0
54
256
2.32
6.75
9.9
3.2
5.80
5.86
kpa
0.19
54
246
51
237
2.36
6.67
2.3
1.8
354.35
376.72
nmol/l
0.24
43
219
309
2686
2.65
6.61
33.0
17.7
4.01
3.99
mmol/l
0.73
298
2613
190
1402
1.81
6.59
5.8
6.0
10.37
11.65
umol/l
1.08
178
1318
242
1933
1.87
6.35
4.3
3.8
15.16
14.88
pmol/l
0.72
206
1743
11
10
11.32
6.34
1.1
1.2
—
—
—
0
0
59
304
2.14
6.02
8.7
9.0
1.02
1.30
mmol/l
0.24
46
249
75
426
1.98
5.88
4.6
2.2
11.16
12.72
umol/l
0.80
68
392
46
218
2.28
5.74
8.9
2.8
4.51
4.29
kpa
0.35
46
207
149
1066
1.71
5.42
2.5
2.0
98.50
95.87
pmol/l
0.22
81
556
276
2351
1.92
5.30
5.3
4.6
1.83
1.97
mu/l
1.17
239
2130
14
27
5.36
5.14
3.7
2.3
—
—
—
0
0
32
137
2.47
5.00
9.0
2.5
1.23
1.31
%
0.23
32
137
129
903
1.69
4.99
3.3
3.1
2.34
2.35
mmol/l
0.39
99
793
59
326
1.98
4.96
5.9
4.4
32.42
31.80
%
0.18
43
209
40
192
2.23
4.85
4.4
2.7
59.90
63.84
ml/min/173m2
0.15
20
76
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
10
9.21
4.81
1.1
1.3
—
—
—
0
0
41
204
2.15
4.56
2.1
1.6
—
—
—
0
0
142
1044
1.62
4.42
3.0
2.3
74.05
77.39
nmol/l
0.75
125
931
171
1315
1.60
4.41
4.9
3.9
0.00
0.00
estimate
0.50
34
281
8
9
9.07
4.30
2.1
2.6
—
—
—
0
0
11
21
5.38
4.17
1.1
1.1
—
—
—
0
0
171
1331
1.57
4.09
4.9
3.9
0.00
0.00
estimate
-0.00
29
252
306
2762
2.08
4.09
15.4
10.2
25.95
25.52
u/l
0.19
293
2658
169
1316
1.57
4.01
6.2
5.2
0.00
0.00
estimate
-0.00
30
260
32
152
2.22
3.99
2.1
1.7
—
—
—
0
0
112
794
1.61
3.96
5.2
3.7
17.49
10.27
mg/mmol
0.90
79
490
315
2881
2.27
3.95
38.6
21.8
38.96
40.03
%
1.80
289
2706
315
2881
2.27
3.95
38.2
21.7
245.74
245.96
e9/l
0.02
302
2813
315
2884
2.25
3.89
38.2
21.7
4.36
4.47
e12/l
2.76
303
2803
104
727
1.62
3.88
5.7
4.2
0.00
0.00
estimate
0.50
28
252
9
15
6.13
3.84
1.1
1.3
—
—
—
0
0
9
15
6.13
3.84
1.1
1.3
—
—
—
0
0
315
2887
2.24
3.83
38.4
21.8
131.38
134.81
g/l
3.38
306
2841
88
593
1.65
3.79
1.6
1.8
473.00
11633100.55
pmol/l
0.50
72
490
14
39
3.70
3.74
1.9
1.7
—
—
—
0
0
274
2409
1.71
3.73
8.3
5.8
43.60
40.25
mmol/mol
3.81
244
2235
291
2602
1.82
3.73
5.8
4.9
2.46
2.71
mmol/l
5.09
262
2368
27
123
2.30
3.72
11.9
3.2
23.47
24.17
mmol/l
0.63
27
118
10
20
5.12
3.71
1.2
1.5
—
—
—
0
0
19
75
2.62
3.53
1.8
1.5
—
—
—
0
0
21
88
2.48
3.47
1.2
1.3
—
—
—
0
0
22
96
2.38
3.34
4.6
1.9
2.91
3.00
g/l
0.10
14
87
6
7
8.70
3.27
1.0
1.3
—
—
—
0
0
273
2431
1.62
3.16
4.6
4.0
1.39
1.30
mmol/l
1.07
243
2204
9
20
4.59
3.13
1.1
1.4
—
—
—
0
0
201
1679
1.48
3.12
3.8
3.0
61.36
50.26
u/l
1.05
190
1550
104
761
1.53
3.10
3.7
3.0
0.26
0.53
e6/l
1.37
91
583
6
8
7.61
3.06
1.2
1.4
—
—
—
0
0
85
597
1.57
3.04
5.9
4.1
1.02
1.02
kg/l
0.07
16
80
7
12
5.93
3.03
1.1
1.0
—
—
—
0
0
5
5
10.12
2.99
1.0
1.0
—
—
—
0
0
5
5
10.12
2.99
1.0
1.0
877.40
1428.20
miu/ml
—
5
5
10
27
3.78
2.90
1.1
1.3
—
—
—
0
0
21
96
2.27
2.90
4.7
1.9
10.14
10.10
g/l
0.02
13
86
22
104
2.19
2.81
4.6
1.9
7.29
7.53
g/l
0.22
14
95
22
104
2.19
2.81
4.6
1.9
3.97
3.52
g/l
0.40
14
95
22
104
2.19
2.81
4.6
1.9
—
—
—
0
0
12
39
3.15
2.80
1.3
1.3
—
—
—
0
0
93
678
1.51
2.79
1.7
1.5
19.66
20.83
nmol/l
0.26
75
576
5
6
8.43
2.76
1.0
1.5
—
—
—
0
0
66
447
1.59
2.74
3.5
2.7
1.07
1.14
e6/l
0.05
49
258
12
44
2.79
2.57
1.1
1.3
—
—
—
0
0
6
11
5.53
2.55
1.2
1.1
—
—
—
0
0
93
691
1.48
2.52
3.6
2.7
4949.26
7488.50
umol/l
0.21
82
590
11
37
3.04
2.51
12.9
2.1
63.00
58.94
%
0.24
11
37
18
83
2.23
2.45
5.3
2.0
36.18
37.46
g/l
—
10
74
277
2522
1.53
2.41
6.1
4.6
6.34
5.98
mmol/l
2.36
243
2299
130
1037
1.41
2.39
5.2
4.1
—
—
—
0
0
7
17
4.18
2.37
8.6
1.8
975.86
440.17
e6/l
—
7
12
108
837
1.43
2.33
3.6
3.0
36.42
31.16
u/l
0.46
101
796
38
233
1.71
2.32
1.9
2.1
0.23
0.22
g/l
0.47
33
222
14
59
2.43
2.32
1.5
1.4
—
—
—
0
0
78
572
1.47
2.24
2.2
1.7
1.87
1.36
mg/l
0.33
56
442
278
2546
1.50
2.22
5.3
4.4
4.33
4.61
mmol/l
4.27
250
2336
5
9
5.62
2.22
1.0
1.3
—
—
—
0
0
7
19
3.74
2.16
1.1
1.3
—
—
—
0
0
18
88
2.10
2.15
2.7
2.6
—
—
—
0
0
276
2531
1.48
2.12
5.4
4.3
1.36
1.46
mmol/l
3.68
245
2310
70
509
1.47
2.10
5.6
3.9
573.96
178.60
ng/l
0.81
56
408
10
37
2.75
2.08
1.4
1.2
134.60
291.89
u/ml
—
5
19
70
511
1.47
2.06
3.3
2.9
2.47
2.46
mmol/l
0.12
55
446
6
16
3.80
1.94
2.7
1.9
—
—
—
0
0
6
16
3.80
1.94
2.7
1.9
—
—
—
0
0
6
16
3.80
1.94
1.2
1.8
—
—
—
0
0
8
28
2.90
1.87
2.3
1.8
—
—
—
0
0
8
28
2.90
1.87
2.3
1.8
—
—
—
0
0
8
28
2.90
1.87
2.3
1.8
—
—
—
0
0
15
73
2.10
1.83
4.3
2.2
26.70
24.56
mmol/l
1.31
15
73
7
23
3.09
1.81
1.6
2.9
—
—
—
0
0
44
300
1.54
1.79
3.5
3.9
3.07
14.21
ug/l
1.49
33
257
17
89
1.96
1.73
5.5
2.2
0.62
0.99
g/l
—
10
76
45
313
1.50
1.68
2.1
2.6
10.16
9.01
umol/l
0.16
38
264
10
40
2.54
1.68
1.6
1.5
—
—
—
0
0
10
40
2.54
1.68
1.6
1.5
—
—
—
0
0
10
40
2.54
1.68
1.6
1.5
—
—
—
0
0
8
32
2.54
1.60
2.4
1.8
—
—
—
0
0
45
317
1.48
1.59
2.0
1.8
—
—
—
0
0
5
15
3.37
1.53
1.0
1.3
—
—
—
0
0
11
51
2.20
1.52
1.7
1.5
—
—
—
0
0
262
2428
1.34
1.50
22.5
14.1
73.83
78.38
ml/min/173m2
1.89
228
2008
11
52
2.15
1.46
1.2
1.5
—
—
—
0
0
13
66
2.01
1.45
1.5
2.5
213.71
68.93
ug/min
—
7
36
5
16
3.16
1.44
1.0
1.2
—
—
—
0
0
9
39
2.34
1.44
1.7
1.5
—
—
—
0
0
9
39
2.34
1.44
1.7
1.5
—
—
—
0
0
6
22
2.76
1.44
1.0
1.5
—
—
—
0
0
6
22
2.76
1.44
1.2
1.1
—
—
—
0
0
9
40
2.28
1.41
1.7
1.5
—
—
—
0
0
6
24
2.53
1.31
1.0
1.0
—
—
—
0
0
12
216
0.54
1.30
1.6
1.7
—
—
—
0
0
44
323
1.42
1.28
2.1
1.8
—
—
—
0
0
10
49
2.07
1.23
3.0
2.6
4.08
4.54
e9/l
—
10
49
8
38
2.13
1.19
1.3
1.3
0.56
0.52
nmol/l
—
8
31
67
535
1.31
1.16
1.4
1.2
3.16
1.38
u/ml
0.31
17
144
8
39
2.08
1.16
1.3
1.5
—
—
—
0
0
11
58
1.93
1.13
1.7
1.3
—
—
—
0
0
10
51
1.99
1.12
2.0
1.6
—
—
—
0
0
10
51
1.99
1.12
3.2
3.1
57.30
58.92
%
—
10
51
10
51
1.99
1.12
2.0
1.6
—
—
—
0
0
8
41
1.97
1.09
1.3
1.5
—
—
—
0
0
7
32
2.21
1.08
2.1
1.6
11.66
15.35
ug/l
—
7
32
101
861
1.25
1.05
5.0
5.0
1.58
2.78
ug/l
1.93
88
767
5
22
2.29
1.03
1.2
1.1
—
—
—
0
0
36
267
1.39
1.01
4.2
3.7
—
—
—
0
0
5
23
2.19
0.98
3.0
2.0
—
—
—
0
0
12
69
1.77
0.97
1.7
1.7
—
—
—
0
0
7
36
1.96
0.97
1.3
1.0
—
—
—
0
0
12
70
1.74
0.94
1.2
1.2
—
—
—
0
0
6
28
2.16
0.92
1.2
1.1
—
—
—
0
0
6
28
2.16
0.92
1.2
1.2
—
—
—
0
0
6
30
2.02
0.87
2.8
1.9
—
—
—
0
0
10
57
1.78
0.84
1.0
1.1
—
—
—
0
0
8
47
1.72
0.81
1.3
1.5
—
—
—
0
0
0
24
0.00
0.79
0.0
1.5
—
—
—
0
0
12
75
1.62
0.76
1.9
1.5
—
—
—
0
0
5
24
2.10
0.75
1.0
1.3
—
—
—
0
0
5
26
1.94
0.71
1.4
1.3
—
62.00
—
0
5
78
676
1.20
0.69
1.9
1.6
1.45
1.38
mmol/l
0.27
73
564
11
69
1.61
0.69
1.6
1.2
—
—
—
0
0
10
63
1.61
0.62
1.2
1.3
—
—
—
0
0
50
420
1.22
0.61
3.7
2.9
1.56
2.16
e6/l
0.48
33
235
12
80
1.52
0.60
1.8
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.5
—
—
—
0
0
8
54
1.49
0.57
2.5
1.6
—
—
—
0
0
8
55
1.47
0.56
1.1
1.3
—
—
—
0
0
9
61
1.49
0.54
4.0
1.4
489.78
280.55
mu/l
—
9
56
166
1553
1.13
0.53
2.7
2.9
—
—
—
0
0
9
64
1.42
0.52
1.2
1.4
—
—
—
0
0
49
426
1.18
0.44
1.1
1.3
75.08
32.33
iu/ml
0.35
18
145
5
33
1.52
0.41
1.6
1.1
—
—
—
0
0
5
33
1.52
0.41
1.0
1.1
—
—
—
0
0
5
33
1.52
0.41
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
37.93
—
0
10
0
18
0.00
0.40
0.0
1.0
—
510.90
—
0
10
44
502
0.86
0.39
3.0
3.0
0.73
0.82
ug/l
0.33
35
323
0
19
0.00
0.39
0.0
1.4
—
187.75
—
0
19
0
19
0.00
0.39
0.0
2.1
—
13.72
—
0
19
5
37
1.36
0.37
3.8
1.6
—
—
—
0
0
36
406
0.87
0.29
1.2
1.3
13.41
8.09
u/ml
—
9
160
28
322
0.86
0.29
1.3
1.4
—
—
—
0
0
9
74
1.22
0.25
2.3
1.5
—
—
—
0
0
9
77
1.17
0.24
2.1
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
5.1
—
225.45
—
0
11
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
5
43
1.17
0.21
1.2
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
2.9
—
—
—
0
0
0
14
0.00
0.20
0.0
2.9
—
—
—
0
0
6
53
1.13
0.19
1.3
1.4
0.86
0.83
nmol/l
—
6
44
71
674
1.07
0.16
4.6
4.4
23.06
20.62
%
0.57
36
313
9
85
1.06
0.07
1.2
1.2
—
—
—
0
0
9
87
1.04
0.07
1.2
1.1
—
—
—
0
0
38
396
0.95
0.06
2.0
1.5
—
—
—
0
0
9
104
0.86
0.06
2.9
1.6
—
—
—
0
0
21
198
1.06
0.05
1.3
1.8
—
—
—
0
0
12
129
0.93
0.03
1.2
1.3
—
—
—
0
0
21
219
0.96
0.03
1.3
1.9
—
—
—
0
0
12
127
0.94
0.01
1.7
2.9
58.00
59.29
u/ml
0.01
12
122
27
267
1.01
0.00
1.6
1.8
1.70
1.50
%
0.84
21
240
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
79.17
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
26.70
—
0
6
6
61
0.98
-0.00
2.0
1.4
—
—
—
0
0
12
120
1.00
-0.00
1.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
61
0.98
-0.00
2.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
84
0.95
-0.00
2.8
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
61
0.98
-0.00
1.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_BLINDMONOCULAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BLINDMONOCULAR | 1.341 [1.11, 1.62] | 0.003 |
| Birth year | 0.995 [0.99, 1.0] | 0.25 |
During the follow-up period (1.1.1998 — 31.12.2019), 434 out of 1186 females with H7_BLINDMONOCULAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BLINDMONOCULAR | 1.671 [1.36, 2.06] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 458 out of 1223 males with H7_BLINDMONOCULAR died.
Mortality risk
Mortality risk for people of age
years, who have H7_BLINDMONOCULAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.173% | 0.358% |
| 5 | 0.869% | 2.093% |
| 10 | 1.878% | 4.866% |
| 15 | 3.93% | 9.27% |
| 20 | 6.913% | 16.066% |
Relationships between endpoints
↥Index endpoint: H7_BLINDMONOCULAR – Blindness, monocular
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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