No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
313 |
4. Check minimum number of eventsNone |
313 |
5. Include endpointsNone |
313 |
6. Filter based on genotype QC (FinnGen only) |
313 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amaurosis unius oculi
Similar endpoints
↥List of similar endpoints to
Blindness, monocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2797 | 1353 | 1421 |
| Only index persons | 2501 | 1233 | 1268 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 68.28 | 72.20 | 64.44 |
| Only index persons | 67.17 | 71.56 | 62.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 313 | 162 | 151 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.07 |
| Median age at first event (years) | 64.27 | 62.76 | 65.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 283
- Matched controls
- 2829
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.4
ICD-10 Finland
Blindness, monocular
+∞
323.0
282
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
90.8
42.3
46
6
114
Kela drug reimbursment
Glaucoma
9.2
38.5
88
132
XCK00
NOMESCO Finland
Perimetry
12.5
37.6
71
74
S01ED51
ATC
timolol, combinations; ophthalmic
9.9
36.7
79
106
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.5
29.4
86
179
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.6
28.6
97
242
H33.0
ICD-10 Finland
Retinal detachment with retinal break
20.1
28.6
43
25
S01EC01
ATC
acetazolamide; systemic
22.0
27.5
40
21
S01ED01
ATC
timolol; ophthalmic
11.2
25.8
50
53
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.8
24.8
157
697
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.7
24.3
169
808
H53.4
ICD-10 Finland
Visual field defects
136.6
24.0
25
*
S01EE01
ATC
latanoprost; ophthalmic
7.8
22.4
54
83
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
237.6
21.9
22
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
16.5
21.8
35
24
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
7.8
21.7
52
79
H53.1
ICD-10 Finland
Subjective visual disturbances
17.4
21.7
34
22
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.4
21.0
87
257
S01EC04
ATC
brinzolamide; ophthalmic
12.4
20.9
38
35
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.2
20.1
57
110
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.8
18.7
44
65
H34.1
ICD-10 Finland
Central retinal artery occlusion
56.4
18.2
21
*
H16.0
ICD-10 Finland
Corneal ulcer
8.2
17.2
39
54
XCK10
NOMESCO Finland
Photography of fundus of eye
4.5
17.1
66
179
AA1AD
NOMESCO Finland
CT of head and brain
3.4
16.8
102
404
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
11.0
15.9
30
30
H54.0
ICD-10 Finland
Blindness, binocular
+∞
15.8
15
*
H44.5
ICD-10 Finland
Degenerated conditions of globe
169.0
15.6
16
*
S01EC03
ATC
dorzolamide; ophthalmic
17.4
15.5
24
15
H34.8
ICD-10 Finland
Other retinal vascular occlusions
11.0
15.4
29
29
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
38.3
14.6
18
5
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.8
14.4
129
651
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
10.2
13.8
27
29
CKD40
NOMESCO Finland
Endophotocoagulation of retina
17.3
13.7
21
13
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
30.0
13.1
17
6
XCD10
NOMESCO Finland
Electrophysiological examination of eye
9.8
13.0
26
29
CKD15
NOMESCO Finland
Injection of vitreous substitute
52.6
13.0
15
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
12.7
146
836
H54.5
ICD-10 Finland
Severe visual impairment, monocular
+∞
12.6
12
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
12.6
12
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
135.8
12.5
13
*
WX140
NOMESCO Finland
Parabulbar anesthesy
5.7
12.5
36
70
H46
ICD-10 Finland
Optic neuritis
39.4
12.3
15
*
H26.4
ICD-10 Finland
After-cataract
4.1
12.2
50
141
S01FA01
ATC
atropine; ophthalmic
28.1
12.2
16
6
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
124.9
11.5
12
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
9.2
11.3
23
27
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.1
11.1
45
126
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
45.2
11.0
13
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
6.4
10.8
28
48
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
5.5
10.5
31
62
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
114.1
10.5
11
*
H47.2
ICD-10 Finland
Optic atrophy
33.9
10.4
13
*
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
24.4
10.3
14
6
S01EX03
ATC
NA
7.7
10.2
23
32
ZXA05
NOMESCO Finland
Left side
2.5
10.1
95
474
H27.0
ICD-10 Finland
Aphakia
41.6
10.0
12
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
20.9
9.9
14
7
CKC12
NOMESCO Finland
Photocoagulation of retina
5.2
9.8
30
63
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
57.0
9.7
11
*
B01AC04
ATC
clopidogrel; oral
2.9
9.7
62
246
I10
ICD-10 Finland
Essential (primary) hypertension
2.2
9.5
182
1266
G45.3
ICD-10 Finland
Amaurosis fugax
13.0
9.5
16
13
CS494
NOMESCO Finland
Other visual field testing
13.0
9.5
16
13
H54.7
ICD-10 Finland
Unspecified visual loss
103.3
9.5
10
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.2
9.3
35
91
H53.9
ICD-10 Finland
Visual disturbance, unspecified
14.3
9.3
15
11
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
12.0
9.2
16
14
S01EA03
ATC
apraclonidine; ophthalmic
16.3
9.1
14
9
C10AA01
ATC
simvastatin; oral
2.1
8.7
145
932
Z97.0
ICD-10 Finland
Presence of artificial eye
51.6
8.7
10
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
10.5
8.6
16
16
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.6
8.6
39
120
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
7.8
8.6
19
26
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
20.8
8.5
12
6
S01ED02
ATC
betaxolol; ophthalmic
13.3
8.5
14
11
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.9
8.4
34
95
CDC00
NOMESCO Finland
Enucleation of eye
+∞
8.4
8
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
8.2
82
415
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
17.8
8.1
12
7
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.0
8.1
47
174
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
22.8
8.1
11
5
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.8
8.1
34
99
A10AA01
ATC
NA
6.4
8.0
20
33
H04.10
ICD-10 Finland
Dry eye syndrome
3.7
8.0
35
105
S01EE04
ATC
travoprost; ophthalmic
8.1
8.0
17
22
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.1
8.0
17
22
H20.1
ICD-10 Finland
Chronic iridocyclitis
11.3
7.9
14
13
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
4.4
7.7
27
66
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
4.9
7.7
24
52
S01EE05
ATC
tafluprost; ophthalmic
5.7
7.7
21
39
Z94.0
ICD-10 Finland
Kidney transplant status
19.0
7.7
11
6
N03AX14
ATC
levetiracetam; systemic
9.2
7.6
15
17
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.2
7.6
28
72
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
25.8
7.6
10
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
25.8
7.6
10
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
10.5
7.6
14
14
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
5.0
7.5
23
49
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
7.5
56
243
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
82.2
7.5
8
*
CDC40
NOMESCO Finland
Evisceration of eye with insertion of prosthesis
82.2
7.5
8
*
H26.2
ICD-10 Finland
Complicated cataract
13.9
7.5
12
9
H40.0
ICD-10 Finland
Glaucoma suspect
3.7
7.4
32
95
H25.1
ICD-10 Finland
Senile nuclear cataract
2.2
7.4
95
538
A10AA02
ATC
NA
4.7
7.3
24
55
H53.2
ICD-10 Finland
Diplopia
+∞
7.3
7
*
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
+∞
7.3
7
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.5
7.3
62
286
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
5.6
7.2
20
38
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
30.9
7.2
9
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
12.5
7.1
12
10
H02AB09
ATC
hydrocortisone; systemic
12.5
7.1
12
10
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
9.1
7.1
14
16
A12AA04
ATC
calcium carbonate; oral
10.4
7.1
13
13
A11CC03
ATC
alfacalcidol; systemic
8.6
6.9
14
17
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
11.3
6.9
12
11
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
17.2
6.8
10
6
137
Kela drug reimbursment
Uraemia requiring dialysis
17.2
6.8
10
6
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
41.1
6.8
8
*
DAX08
NOMESCO Finland
Fitting of hearing aid
5.4
6.8
19
37
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
10.4
6.6
12
12
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
10.4
6.6
12
12
C08CA01
ATC
amlodipine; oral
2.0
6.6
108
671
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.4
6.5
58
275
A28
ICPC
Limited function/disability NOS
2.4
6.5
60
289
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.8
6.5
42
167
ZXA00
NOMESCO Finland
Right side
2.1
6.5
89
510
H33.4
ICD-10 Finland
Traction detachment of retina
71.4
6.5
7
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
71.4
6.5
7
*
H21.0
ICD-10 Finland
Hyphaema
71.4
6.5
7
*
37520
ICD-8 Finland
Glaucoma, Secondary
71.4
6.5
7
*
N02BE01
ATC
paracetamol; systemic, rectal
2.3
6.4
241
2025
H3603, E103
ICD-10 Finland
NA
8.5
6.4
13
16
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.2
6.4
23
59
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.4
6.3
29
91
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
+∞
6.3
6
*
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
27.3
6.3
8
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.0
6.2
16
28
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
6.2
43
178
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
4.8
6.1
19
42
H57.1
ICD-10 Finland
Ocular pain
5.0
6.0
18
38
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
70
192
4.41
23.76
11.4
6.4
12.5
10.3
mmol/l
1.32
64
182
143
740
2.72
16.53
3.0
2.0
273.7
220.4
u/l
0.33
135
698
16
14
11.99
15.43
1.2
1.2
—
—
—
0
0
75
295
3.03
14.28
11.4
5.1
1.1
1.0
mmol/l
0.57
69
266
167
1002
2.43
13.33
5.6
3.9
31.9
44.4
ng/l
1.02
138
722
46
140
3.68
13.19
6.6
3.2
2.7
1.5
mmol/l
1.21
34
108
211
1417
2.50
12.94
7.9
4.9
7.4
6.8
mmol/l
2.96
201
1314
13
12
11.26
12.03
1.3
1.9
—
—
—
0
0
115
610
2.40
11.79
2.6
2.1
3.6
3.3
mg/l
0.48
92
532
172
1093
2.27
11.43
13.2
6.1
1.2
1.2
mmol/l
1.01
154
993
14
17
8.57
10.69
1.0
1.1
—
—
—
0
0
57
224
2.89
10.69
2.5
2.5
4.7
7.0
ug/l
0.56
44
200
32
89
3.89
10.39
2.4
1.8
—
—
—
0
0
35
106
3.59
10.05
1.8
2.4
1.7
1.5
g/l
0.24
24
95
132
787
2.17
9.88
3.5
3.4
2403.9
1530.1
ng/l
1.12
115
676
33
98
3.65
9.75
2.8
2.0
—
—
—
0
0
95
506
2.26
9.32
2.0
1.7
1293.0
1210.9
nmol/l
0.30
73
379
160
1051
2.07
9.07
6.5
4.4
34.6
35.3
g/l
0.83
142
980
176
1199
2.07
9.01
15.1
6.7
1.2
1.2
mmol/l
1.47
155
1025
48
188
2.83
9.00
3.3
2.6
64.1
66.7
g/l
1.40
39
168
70
336
2.40
8.68
4.2
2.2
18.7
21.9
%
1.67
57
288
72
356
2.33
8.32
4.1
2.1
2.3
2.3
g/l
0.55
64
321
24
65
3.92
8.07
1.7
1.9
—
—
—
0
0
150
992
1.98
8.05
3.8
2.6
167.6
131.2
ug/l
1.13
134
906
62
292
2.40
7.98
10.5
7.9
—
—
—
0
0
40
154
2.83
7.72
1.7
1.4
—
—
—
0
0
67
335
2.27
7.49
31.0
26.9
1.4
1.3
inr
—
7
36
13
22
6.12
7.44
3.9
2.4
—
—
—
0
0
79
425
2.15
7.37
2.4
1.8
—
—
—
0
0
189
1392
1.90
7.00
10.6
9.0
4.3
4.1
e9/l
0.36
170
1233
234
1858
2.03
6.84
9.6
7.1
78.4
78.7
u/l
0.04
221
1732
50
230
2.40
6.74
8.3
3.3
1.3
2.2
mmol/l
1.29
42
175
121
780
1.90
6.71
2.5
2.5
84.8
54.9
u/l
0.36
113
722
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
65
3.56
6.55
2.5
3.1
0.4
0.3
u/ml
0.51
15
40
50
235
2.34
6.41
8.2
3.2
5.8
5.8
kpa
0.03
50
224
278
2382
2.49
6.35
26.2
15.1
23.5
23.4
mg/l
0.02
231
1904
134
905
1.84
6.34
4.8
3.1
—
—
—
0
0
71
389
2.07
6.24
4.4
2.1
11.4
12.7
umol/l
0.61
64
355
44
199
2.41
6.14
7.4
2.7
4.4
4.3
kpa
0.20
44
187
47
219
2.35
6.14
2.4
1.8
350.5
380.1
nmol/l
0.33
40
202
10
8
12.86
6.12
1.1
1.0
—
—
—
0
0
56
282
2.20
6.10
9.0
9.0
5.0
5.1
kpa
0.05
51
270
224
1787
1.89
6.00
4.8
4.0
17.1
12.6
mm/h
2.63
204
1645
282
2450
2.52
5.91
32.7
17.6
139.3
139.7
mmol/l
1.21
272
2386
91
554
1.91
5.89
3.8
2.5
—
—
—
0
0
173
1284
1.78
5.81
5.5
6.1
10.1
11.6
umol/l
1.44
162
1209
151
1080
1.77
5.74
5.9
4.4
—
—
—
0
0
282
2458
2.49
5.73
33.0
17.7
4.0
4.0
mmol/l
0.82
272
2391
10
17
6.04
5.66
1.2
1.5
—
—
—
0
0
39
175
2.40
5.53
4.4
2.9
59.9
63.7
ml/min/173m2
0.15
20
70
57
302
2.09
5.43
9.7
6.5
103.9
103.9
mmol/l
0.01
57
292
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
8
11.54
5.32
1.1
1.3
—
—
—
0
0
54
285
2.08
5.19
9.2
9.0
1.2
1.2
mmol/l
0.05
43
229
40
188
2.29
5.12
2.1
1.6
—
—
—
0
0
219
1776
1.78
5.09
4.2
3.7
15.2
14.9
pmol/l
0.66
186
1598
120
826
1.73
5.06
3.2
3.1
2.3
2.4
mmol/l
0.29
93
715
30
126
2.53
4.90
6.9
2.4
1.2
1.3
%
0.11
30
126
136
979
1.69
4.82
2.5
2.0
96.2
95.8
pmol/l
0.02
75
506
10
20
5.13
4.81
1.1
1.1
—
—
—
0
0
13
34
3.95
4.58
1.8
1.7
—
—
—
0
0
159
1204
1.65
4.56
4.3
3.9
0.0
0.0
estimate
0.00
29
241
250
2144
1.82
4.39
5.3
4.5
1.8
2.0
mu/l
1.04
216
1940
9
12
7.68
4.38
1.1
1.4
—
—
—
0
0
9
12
7.68
4.38
1.1
1.4
—
—
—
0
0
8
9
9.08
4.30
2.1
2.6
—
—
—
0
0
158
1225
1.59
3.91
4.4
3.9
0.0
0.0
estimate
0.00
28
230
97
669
1.65
3.89
5.0
4.3
0.0
0.0
estimate
0.50
26
230
18
66
2.83
3.82
1.9
1.4
—
—
—
0
0
29
135
2.27
3.81
2.1
1.8
—
—
—
0
0
6
5
12.20
3.78
1.0
1.2
—
—
—
0
0
156
1213
1.57
3.77
5.6
5.2
0.0
0.0
estimate
0.00
28
237
81
540
1.67
3.68
1.6
1.8
479.3
12752119.5
pmol/l
0.50
66
447
20
81
2.57
3.54
1.3
1.3
—
—
—
0
0
9
17
5.42
3.53
1.1
1.5
—
—
—
0
0
50
295
1.83
3.47
6.1
4.4
31.9
32.1
%
0.04
37
188
288
2637
2.15
3.46
38.3
21.9
131.4
134.9
g/l
3.10
280
2595
103
740
1.58
3.44
5.3
3.9
15.6
9.1
mg/mmol
1.00
71
459
279
2528
1.95
3.43
15.1
10.2
25.5
25.6
u/l
0.03
267
2430
10
27
3.79
3.38
1.1
1.3
—
—
—
0
0
127
965
1.53
3.28
3.1
2.3
75.2
77.0
nmol/l
0.32
112
861
81
555
1.62
3.28
5.0
4.3
1.0
1.0
kg/l
0.09
15
74
6
7
8.71
3.27
1.2
1.1
—
—
—
0
0
97
698
1.56
3.18
3.4
3.0
0.3
0.5
e6/l
0.97
84
532
20
86
2.42
3.15
4.8
2.0
3.1
3.1
g/l
—
10
69
5
5
10.13
2.99
1.0
1.2
—
—
—
0
0
11
35
3.22
2.96
1.2
1.2
—
—
—
0
0
264
2387
1.68
2.82
5.8
4.9
2.5
2.7
mmol/l
4.34
238
2174
19
85
2.32
2.76
4.9
2.0
9.6
10.2
g/l
—
10
74
20
92
2.25
2.73
4.8
2.0
4.2
3.7
g/l
—
10
67
20
92
2.25
2.73
4.8
2.0
—
—
—
0
0
20
92
2.25
2.73
4.8
2.0
7.2
7.6
g/l
—
10
70
6
10
6.09
2.71
1.2
1.1
—
—
—
0
0
10
32
3.20
2.67
1.6
1.6
—
—
—
0
0
10
32
3.20
2.67
1.6
1.6
—
—
—
0
0
10
32
3.20
2.67
1.6
1.6
—
—
—
0
0
74
522
1.55
2.61
2.2
1.7
1.9
1.4
mg/l
0.32
54
406
247
2213
1.55
2.57
8.4
5.9
43.6
40.3
mmol/mol
3.46
221
2054
6
11
5.54
2.55
2.7
2.3
—
—
—
0
0
6
11
5.54
2.55
2.7
2.3
—
—
—
0
0
6
11
5.54
2.55
2.7
2.3
—
—
—
0
0
6
11
5.54
2.55
2.7
2.3
—
—
—
0
0
11
39
2.89
2.50
1.0
1.3
—
—
—
0
0
13
51
2.62
2.47
1.5
1.4
—
—
—
0
0
6
12
5.07
2.41
1.2
1.0
—
—
—
0
0
60
411
1.57
2.40
3.3
2.6
1.1
1.1
e6/l
0.04
44
236
5
8
6.33
2.38
1.0
1.3
—
—
—
0
0
180
1529
1.42
2.38
3.8
2.9
59.5
49.9
u/l
0.98
170
1417
85
632
1.47
2.32
3.7
2.7
5380.3
6959.2
umol/l
0.11
75
539
66
466
1.53
2.31
3.2
3.0
2.5
2.5
mmol/l
0.28
52
404
121
963
1.42
2.29
4.6
4.1
—
—
—
0
0
247
2231
1.51
2.29
4.7
4.0
1.4
1.3
mmol/l
1.08
220
2022
35
211
1.74
2.28
1.8
2.0
0.2
0.2
g/l
0.38
30
202
8
23
3.54
2.28
2.3
1.9
—
—
—
0
0
8
23
3.54
2.28
2.3
1.9
—
—
—
0
0
8
23
3.54
2.28
2.3
1.9
—
—
—
0
0
7
18
3.95
2.26
1.1
1.3
—
—
—
0
0
16
74
2.22
2.18
5.6
2.1
37.2
37.5
g/l
—
9
64
17
81
2.16
2.17
2.1
2.6
—
—
—
0
0
9
31
2.96
2.09
1.7
1.6
—
—
—
0
0
97
756
1.41
2.03
3.2
3.0
37.2
31.0
u/l
0.50
90
722
8
26
3.13
2.02
2.4
1.9
—
—
—
0
0
9
32
2.86
2.01
1.7
1.6
—
—
—
0
0
9
32
2.86
2.01
1.7
1.6
—
—
—
0
0
233
2105
1.42
1.95
23.7
15.8
39.1
39.7
%
0.34
132
1498
81
625
1.40
1.78
1.7
1.5
20.2
20.8
nmol/l
0.10
66
530
250
2302
1.43
1.75
6.2
4.6
6.4
6.0
mmol/l
2.11
219
2100
5
14
3.61
1.62
1.2
1.9
—
—
—
0
0
6
20
3.04
1.59
1.2
1.1
—
—
—
0
0
41
286
1.50
1.53
2.1
2.6
7.7
9.2
umol/l
0.26
34
243
15
79
1.94
1.52
5.9
2.3
0.7
0.9
g/l
—
9
68
251
2332
1.39
1.50
5.3
4.4
4.3
4.6
mmol/l
3.75
227
2141
12
59
2.08
1.45
1.6
2.8
243.8
69.4
ug/min
—
6
33
239
2210
1.34
1.42
21.9
14.1
73.7
78.1
ml/min/173m2
1.65
207
1825
41
292
1.47
1.40
2.0
1.7
—
—
—
0
0
249
2320
1.36
1.38
5.4
4.4
1.4
1.5
mmol/l
3.34
222
2118
39
276
1.47
1.37
3.4
4.1
3.1
9.2
ug/l
2.38
30
236
6
23
2.64
1.37
1.7
3.1
—
—
—
0
0
12
61
2.01
1.34
1.7
1.8
—
—
—
0
0
6
24
2.53
1.31
2.8
2.0
—
—
—
0
0
61
473
1.36
1.30
5.9
3.9
596.0
175.4
ng/l
0.76
50
375
8
34
2.39
1.30
1.3
1.4
0.6
0.5
nmol/l
—
8
29
10
48
2.12
1.29
1.4
1.5
—
—
—
0
0
8
36
2.25
1.25
1.3
1.5
—
—
—
0
0
10
49
2.08
1.23
1.2
1.4
—
—
—
0
0
6
26
2.33
1.19
1.2
1.3
—
—
—
0
0
34
243
1.45
1.16
4.1
3.5
—
—
—
0
0
5
20
2.52
1.15
1.2
1.1
—
—
—
0
0
12
65
1.88
1.15
1.6
1.5
—
0.2
—
0
13
10
51
1.99
1.12
1.0
1.1
—
—
—
0
0
40
297
1.40
1.11
2.1
1.8
—
—
—
0
0
7
31
2.29
1.11
2.1
1.6
11.7
15.3
ug/l
—
7
31
5
21
2.40
1.09
1.0
1.6
—
—
—
0
0
10
52
1.95
1.07
1.2
1.2
—
—
—
0
0
5
22
2.29
1.04
1.0
1.2
—
—
—
0
0
92
781
1.25
1.01
4.8
5.0
1.6
2.9
ug/l
1.88
81
696
12
198
0.59
0.99
1.6
1.7
—
—
—
0
0
5
23
2.19
0.98
1.4
1.3
—
62.0
—
0
5
11
63
1.77
0.91
1.2
1.3
—
—
—
0
0
6
29
2.09
0.90
1.2
1.1
—
—
—
0
0
8
44
1.84
0.86
1.3
1.4
—
—
—
0
0
10
58
1.75
0.80
1.3
1.2
—
—
—
0
0
14
90
1.58
0.79
9.6
3.3
3.9
3.9
mmol/l
0.00
14
79
12
74
1.65
0.79
1.8
1.8
—
—
—
0
0
6
34
1.78
0.76
1.3
1.0
—
—
—
0
0
11
67
1.67
0.76
2.0
1.5
—
—
—
0
0
5
24
2.10
0.75
1.0
1.0
—
—
—
0
0
7
39
1.81
0.73
1.3
1.5
—
—
—
0
0
9
59
1.54
0.69
1.2
1.3
—
—
—
0
0
8
50
1.62
0.61
1.1
1.3
—
—
—
0
0
5
30
1.68
0.61
1.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.6
—
—
—
0
0
57
488
1.21
0.59
1.4
1.2
3.5
1.5
u/ml
0.31
15
132
45
385
1.20
0.48
3.6
2.8
1.6
2.1
e6/l
0.30
29
214
7
47
1.50
0.48
2.7
1.6
—
—
—
0
0
24
294
0.80
0.44
1.3
1.4
—
—
—
0
0
5
31
1.62
0.43
1.6
1.1
—
—
—
0
0
8
56
1.44
0.43
1.1
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
2.3
—
13.9
—
0
16
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
36.3
—
0
9
0
17
0.00
0.41
0.0
1.0
—
480.7
—
0
9
32
371
0.85
0.35
1.2
1.3
14.8
8.8
u/ml
—
8
145
40
455
0.86
0.35
3.0
3.0
0.7
0.8
ug/l
0.30
33
295
44
390
1.15
0.33
1.1
1.3
71.2
31.7
iu/ml
0.30
17
130
147
1401
1.09
0.31
2.7
2.9
—
—
—
0
0
8
66
1.22
0.27
2.5
1.5
—
—
—
0
0
66
613
1.10
0.24
4.7
4.6
23.3
20.8
%
0.56
34
285
0
10
0.00
0.21
0.0
3.0
—
225.6
—
0
10
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
2.9
—
—
—
0
0
0
14
0.00
0.20
0.0
2.9
—
—
—
0
0
10
122
0.81
0.19
1.2
1.3
—
—
—
0
0
7
87
0.80
0.14
1.6
1.5
—
—
—
0
0
65
621
1.06
0.12
1.9
1.7
1.5
1.4
mmol/l
0.49
60
523
34
360
0.94
0.09
2.1
1.5
—
—
—
0
0
6
54
1.11
0.09
1.0
1.4
—
—
—
0
0
7
67
1.05
0.08
1.6
1.5
—
—
—
0
0
26
247
1.06
0.05
1.7
1.8
1.7
1.5
%
0.95
20
221
18
173
1.04
0.01
1.4
1.8
—
—
—
0
0
18
187
0.96
0.01
1.4
1.9
—
—
—
0
0
11
109
1.01
0.00
1.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
0.00
2.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
5
56
0.89
0.00
2.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
26.7
—
0
6
8
80
1.00
0.00
1.3
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
6
69
0.87
0.00
1.3
1.5
—
—
—
0
0
5
49
1.02
0.00
1.4
1.5
0.9
0.8
nmol/l
—
5
41
0
6
0.00
0.00
0.0
2.5
—
79.2
—
0
6
8
82
0.97
0.00
1.3
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_BLINDMONOCULAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BLINDMONOCULAR | 1.341 [1.11, 1.62] | 0.003 |
| Birth year | 0.995 [0.99, 1.0] | 0.25 |
During the follow-up period (1.1.1998 — 31.12.2019), 434 out of 1186 females with H7_BLINDMONOCULAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BLINDMONOCULAR | 1.671 [1.36, 2.06] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 458 out of 1223 males with H7_BLINDMONOCULAR died.
Mortality risk
Mortality risk for people of age
years, who have H7_BLINDMONOCULAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.173% | 0.358% |
| 5 | 0.869% | 2.093% |
| 10 | 1.878% | 4.866% |
| 15 | 3.93% | 9.27% |
| 20 | 6.913% | 16.066% |
Relationships between endpoints
↥Index endpoint: H7_BLINDMONOCULAR – Blindness, monocular
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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