Risteys · G6_TRIOTHUNS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G50.8, G50.9 Hospital discharge: ICD-9 — 350[8-9] Hospital discharge: ICD-8 — 35601 Cause of death: ICD-10 — G50.8, G50.9 Cause of death: ICD-9 — 350[8-9] Cause of death: ICD-8 — 35601 2 out of 7 registries used, show all original rules.	577
4. Check minimum number of events None	577
5. Include endpoints None	577
6. Filter based on genotype QC (FinnGen only)	577

	All	Female	Male
Number of individuals
Whole population	3637	2471	1148
Only index persons	3305	2291	1014
Unadjusted period prevalence (%)
Whole population	0.06	0.07	0.03
Only index persons	0.07	0.08	0.04
Median age at first event (years)
Whole population	53.77	53.33	54.63
Only index persons	52.31	52.25	52.47

	All	Female	Male
Number of individuals	577	416	161
Unadjusted period prevalence (%)	0.12	0.14	0.07
Median age at first event (years)	53.80	52.54	57.06

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
525: Matched controls
5250

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G50.8

ICD-10 Finland

Other disorders of trigeminal nerve

+∞

323.0

283

G50.9

ICD-10 Finland

Disorder of trigeminal nerve, unspecified

+∞

294.4

254

G50.0

ICD-10 Finland

Trigeminal neuralgia

399.6

193.0

183

G50.1

ICD-10 Finland

Atypical facial pain

254.6

176.1

172

N03AF01

ATC

carbamazepine; oral, rectal

27.3

127.6

181

N03AX12

ATC

gabapentin; oral

12.3

117.7

246

352

N03AX16

ATC

pregabalin; oral

9.5

113.0

295

622

N06AX21

ATC

duloxetine; oral

7.6

55.3

143

246

R51.81

ICD-10 Finland

Facial pain NOS

25.2

55.1

119

Kela drug reimbursment

Trigeminal neuralgia or glossofaryngeusneuralgia

+∞

54.1

N02AX02

ATC

tramadol; systemic, rectal

4.1

51.0

314

1393

SAA04

NOMESCO Finland

Special inverstigation of mouth

10.6

49.9

102

117

SHA03

NOMESCO Finland

Correction of physiology of bite - demanding therapy visit

14.5

49.5

K07.60

ICD-10 Finland

Snapping jaw

10.0

48.3

102

124

G56.0

ICD-10 Finland

Carpal tunnel syndrome

16.3

46.1

N03AF02

ATC

oxcarbazepine; oral

14.1

44.6

SHA02

NOMESCO Finland

Correction of physiology of bite - basic therapy visit

7.3

42.5

110

184

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

3.6

42.3

299

1404

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

3.7

41.2

261

1115

WZB00

NOMESCO Finland

Telephone receipt or other advice

3.8

40.9

240

962

WZC05

NOMESCO Finland

Specialty-specific consultation based on referral by dentist or doctor

8.7

40.0

124

SHB00

NOMESCO Finland

Prepation and fitting of bite rail to mouth

5.5

39.4

129

291

N03AE01

ATC

clonazepam; systemic

7.9

39.2

143

F45.8

ICD-10 Finland

Other somatoform disorders

7.1

38.9

102

172

N06AA09

ATC

amitriptyline; systemic

6.0

38.9

118

242

M03BX01

ATC

baclofen; systemic

22.2

38.4

R52.2

ICD-10 Finland

Other chronic pain

11.7

37.4

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

8.8

36.6

108

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

6.6

35.9

178

N03AX09

ATC

lamotrigine; oral

9.3

35.7

R51.80

ICD-10 Finland

Headache

4.4

33.1

139

401

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

25.8

32.4

SHA01

NOMESCO Finland

Correction of physiology of bite - simple therapy visit

4.6

31.2

121

321

SHA04

NOMESCO Finland

Correction of physiology of bite - very demanding therapy visit

21.3

30.6

EB1AI

NOMESCO Finland

Cone beam imaging of teeth and jaws (one quarter)

15.3

29.5

M79.1

ICD-10 Finland

Myalgia

4.1

28.7

126

374

SAA03

NOMESCO Finland

Extended examination of mouth

2.9

28.7

268

1392

N06AX16

ATC

venlafaxine; oral

4.0

27.3

125

384

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

4.8

27.1

240

ACC51

NOMESCO Finland

Release of median nerve

79.5

27.1

N02AA05

ATC

oxycodone; systemic

4.1

26.0

111

319

A02BC02

ATC

pantoprazole; systemic

2.8

25.7

381

2550

EB1AA

NOMESCO Finland

Tooth X-ray examination

2.7

25.4

339

2122

G51.0

ICD-10 Finland

Bell palsy

261.9

24.9

H02AB06

ATC

prednisolone; systemic

2.6

24.8

285

1628

A02BC05

ATC

esomeprazole; systemic

2.6

24.5

268

1486

M01AE03

ATC

ketoprofen; systemic, rectal

2.6

23.7

245

1305

SBB10

NOMESCO Finland

Teeth copy

5.8

23.4

133

R52.1

ICD-10 Finland

Chronic intractable pain

38.2

23.2

ACC59

NOMESCO Finland

Decompression and freeing of adhesions of peripheral nerve: other or unspecified

239.9

22.8

EB1AD

NOMESCO Finland

Cone beam CT of teeth and jaws (one quarter)

47.3

22.6

M03BX02

ATC

tizanidine; oral

2.6

22.5

363

2445

AA3AI

NOMESCO Finland

Cone beam CT of facial bones

30.6

22.1

M79.2

ICD-10 Finland

Neuralgia and neuritis, unspecified

13.1

21.7

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.7

21.6

189

904

N03

ICPC

Pain face

29.5

21.1

EB1BI

NOMESCO Finland

Cone beam imaging of teeth and jaws (1–2 quarters)

14.9

21.1

K08.80

ICD-10 Finland

Toothache NOS

4.4

21.1

208

N92

ICPC

Trigeminal neuralgia

218.2

20.7

K07.63

ICD-10 Finland

Pain in the jaw joint UNS

11.0

19.5

M01AE02

ATC

naproxen; oral, rectal

2.3

19.3

334

2241

N06CA01

ATC

amitriptyline and psycholeptics; systemic

3.6

19.3

298

A02BC03

ATC

lansoprazole; oral

2.5

19.2

191

965

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.4

19.2

251

1463

AAH30

NOMESCO Finland

Thermal destruction of cranial nerve

+∞

18.9

M03BC01

ATC

orphenadrine (citrate); systemic

2.7

18.8

160

741

R52.9

ICD-10 Finland

Pain, unspecified

4.2

18.6

196

N02BE01

ATC

paracetamol; systemic, rectal

3.1

18.4

466

3779

M01AB05

ATC

diclofenac; systemic, rectal

2.4

18.1

375

2701

R20.2

ICD-10 Finland

Paraesthesia of skin

4.7

17.5

142

M54.5

ICD-10 Finland

Low back pain

2.4

17.4

197

1053

SAA01

NOMESCO Finland

Simple examination of mouth

2.4

17.4

391

2900

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.3

17.3

221

1256

M79.6

ICD-10 Finland

Pain in limb

2.3

17.2

209

1157

J01FF01

ATC

clindamycin; systemic

2.5

17.0

169

842

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

2.2

17.0

280

1789

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.2

16.9

269

1689

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

3.3

16.9

322

Z01.8

ICD-10 Finland

Other specified special examinations

2.6

16.8

145

672

N03AX11

ATC

topiramate; oral

8.7

16.8

J01DB01

ATC

cefalexin; oral

2.6

16.8

444

3543

K08.1

ICD-10 Finland

Loss of teeth due to accident, extraction or local periodontal disease

3.5

16.7

278

TEW99

NOMESCO Finland

Other minor procedure in surgery of teeth, jaws, mouth and pharynx

5.3

16.5

104

WX110

NOMESCO Finland

Local anesthesy

2.3

16.3

379

2804

M75.1

ICD-10 Finland

Rotator cuff syndrome

2.6

15.9

140

652

M01AH05

ATC

etoricoxib; oral

2.2

15.9

325

2258

35601

ICD-8 Finland

Other diseases of cranial nerves, Nervi trigemini

+∞

15.7

N06AA10

ATC

nortriptyline; systemic

8.4

15.5

M79.0

ICD-10 Finland

Rheumatism, unspecified

6.4

15.5

SAA02

NOMESCO Finland

Basic examination of mouth

2.2

15.4

354

2568

AA1AD

NOMESCO Finland

CT of head and brain

2.5

15.3

141

673

R01AD08

ATC

fluticasone; nasal

2.3

15.2

182

991

R20.1

ICD-10 Finland

Hypoaesthesia of skin

46.4

15.1

M25.5

ICD-10 Finland

Pain in joint

2.3

15.1

173

921

M54.4

ICD-10 Finland

Lumbago with sciatica

2.8

14.9

106

435

P01AB01

ATC

metronidazole; oral, rectal

2.1

14.8

236

1452

N02AJ06

ATC

codeine and paracetamol; systemic

2.2

14.8

210

1228

K07.65

ICD-10 Finland

Temporomandibular joint-pain-dysfunction syndrome

19.1

14.8

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.3

14.8

174

935

K07.61

ICD-10 Finland

Cracking jaw joint

11.8

14.4

R01AD09

ATC

mometasone; nasal

2.1

14.4

258

1665

H02AB04

ATC

methylprednisolone; systemic

2.7

14.0

104

436

G44.2

ICD-10 Finland

Tension-type headache

2.8

14.0

388

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

3.6

14.0

203

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.6

13.9

114

508

SGC00

NOMESCO Finland

Local medication of root channels of tooth

3.2

13.5

266

K04.5

ICD-10 Finland

Chronic apical periodontitis

2.3

13.5

156

827

K07.69

ICD-10 Finland

Dislocation of the jaw joint UNS

8.5

13.5

N06AX11

ATC

mirtazapine; oral

2.1

13.5

192

1115

EB1CI

NOMESCO Finland

Cone beam imaging of teeth and jaws (3-4 quarters)

21.8

13.4

N05BA04

ATC

oxazepam; oral

2.2

13.3

156

831

J01MA12

ATC

levofloxacin; systemic

2.6

13.2

108

478

A06AC01

ATC

ispaghula (psylla seeds); oral

2.3

13.2

149

779

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.0

13.1

241

1553

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

2.0

13.1

278

1894

DM1AD

NOMESCO Finland

CT of paranasal sinuses and face area

6.0

13.1

DMB20

NOMESCO Finland

Functional endoscopic opening of maxillary antrum

4.4

13.1

118

K04.1

ICD-10 Finland

Necrosis of pulp

3.2

13.0

255

R20.3

ICD-10 Finland

Hyperaesthesia

51.3

12.9

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.7

12.8

410

WX408

NOMESCO Finland

General anesthesy, balanced

2.2

12.7

154

829

R06.0

ICD-10 Finland

Dyspnoea

2.3

12.7

141

728

SBB00

NOMESCO Finland

Fotograf of mouth and teeth

5.2

12.6

H04.10

ICD-10 Finland

Dry eye syndrome

3.1

12.5

266

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

6.5

12.5

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

3.3

12.3

206

A02BC01

ATC

omeprazole; systemic

2.2

12.3

160

888

UDQ12

NOMESCO Finland

Flexible laryngoscopy

4.4

12.2

106

WZA90

NOMESCO Finland

Other doctors statement

2.2

12.1

138

722

N05AH04

ATC

quetiapine; oral

2.5

12.1

101

451

J01FA10

ATC

azithromycin; systemic

1.9

12.0

320

2344

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

3.6

11.9

161

R53

ICD-10 Finland

Malaise and fatigue

2.3

11.9

120

589

J32.0

ICD-10 Finland

Chronic maxillary sinusitis

3.4

11.9

189

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

2.4

11.9

112

534

R01BA52

ATC

pseudoephedrine, combinations; oral

2.0

11.8

184

1098

K04.00

ICD-10 Finland

Hyperemia of pulp

4.9

11.8

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

2.2

11.7

133

689

S04.3

ICD-10 Finland

Injury of trigeminal nerve

+∞

11.5

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

3.0

11.4

253

UJF32

NOMESCO Finland

Coloscopy

2.1

11.4

147

807

R07.4

ICD-10 Finland

Chest pain, unspecified

2.1

11.3

147

809

SXC05

NOMESCO Finland

Other oral or dental procedure

3.5

11.3

162

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

3.2

11.2

204

J01AA02

ATC

doxycycline; systemic

2.1

11.1

419

3439

L03

ICPC

Low back symptom/complaint

2.1

11.0

138

749

F32.9

ICD-10 Finland

Depressive episode, unspecified

2.7

10.9

300

R42

ICD-10 Finland

Dizziness and giddiness

2.2

10.9

128

675

N02CC01

ATC

sumatriptan; nasal, systemic, rectal

2.5

10.8

428

M54.9

ICD-10 Finland

Dorsalgia, unspecified

2.8

10.8

287

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.0

10.7

184

1129

A01

ICPC

Pain general/multiple sites

3.5

10.7

153

K10.21

ICD-10 Finland

Osteoradionecrosis of jaw (acute)(chronic)(suppurative)

61.2

10.7

M53.0

ICD-10 Finland

Cervicocranial syndrome

3.0

10.7

232

N05CF01

ATC

zopiclone; oral

2.0

10.6

180

1100

J01.0

ICD-10 Finland

Acute maxillary sinusitis

2.2

10.6

128

683

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

3.5

10.6

149

M01AC06

ATC

meloxicam; systemic, rectal

1.9

10.5

198

1261

AAH60

NOMESCO Finland

Microvascular decompression of cranial nerve

+∞

10.4

UJF30

NOMESCO Finland

Ileoscopy through colon

2.9

10.4

244

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

7.3

10.4

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

4.1

10.3

104

SPAT1220

SPAT

Assessment of need for rehabilitation and/or rehabilitation plan

3.5

10.2

142

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

3.1

10.2

205

J45.9

ICD-10 Finland

Asthma, unspecified

2.3

10.0

100

487

SJC03

NOMESCO Finland

Positioning and fixed attachment of brackets, extensive

17.1

9.9

N05BA01

ATC

diazepam; systemic, rectal

2.4

9.9

405

G43.9

ICD-10 Finland

Migraine, unspecified

3.6

9.9

130

2402

FHL

External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)

56.0

9.7

S06.0

ICD-10 Finland

Concussion

2.9

9.6

225

M54.2

ICD-10 Finland

Cervicalgia

3.5

9.6

138

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

2.7

9.6

270

A06AC51

ATC

ispaghula, combinations; systemic

3.7

9.6

117

N05CF02

ATC

zolpidem; oral

2.2

9.6

106

542

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.8

9.5

276

2009

UDH02

NOMESCO Finland

Rhinopharyngoscopy

3.3

9.5

156

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.8

9.5

231

1588

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

2.9

9.5

221

J01MA02

ATC

ciprofloxacin; systemic

1.9

9.5

197

1285

M01AX17

ATC

nimesulide; oral

2.0

9.4

136

776

RF211

NOMESCO Finland

101.8

9.4

R20.0

ICD-10 Finland

Anaesthesia of skin

17.9

9.4

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

4.5

9.4

TAB00

NOMESCO Finland

Lumbar puncture

3.9

9.3

104

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.4

9.2

370

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

3.6

9.1

117

N07BC02

ATC

methadone; systemic

37.4

9.0

M19.9

ICD-10 Finland

Arthrosis, unspecified

5.4

9.0

Z01.9

ICD-10 Finland

Special examination, unspecified

3.6

9.0

118

M01AH02

ATC

rofecoxib; oral

2.4

9.0

354

M79.7

ICD-10 Finland

Fibromyalgia

5.0

9.0

G43.0

ICD-10 Finland

Migraine without aura [common migraine]

3.4

9.0

135

M02AA07

ATC

piroxicam; topical

1.8

9.0

197

1303

WX002

NOMESCO Finland

Sedation and analgesia

2.1

8.9

111

593

N02AC04

ATC

dextropropoxyphene; oral

4.7

8.9

K07.13

ICD-10 Finland

Retrognaty, mandibular

8.2

8.9

A02BA02

ATC

ranitidine; systemic

2.1

8.9

113

612

A07AA02

ATC

nystatin; oral

3.2

8.8

148

A03FA02

ATC

cisapride; oral, rectal

3.0

8.8

183

C07AA05

ATC

propranolol; systemic

2.1

8.7

115

631

H57.1

ICD-10 Finland

Ocular pain

4.9

8.7

R03AC02

ATC

salbutamol; inhalant

1.7

8.6

272

2009

J01FA06

ATC

roxithromycin; oral

1.8

8.6

224

1560

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

3.2

8.6

145

R01AD12

ATC

fluticasone furoate; nasal

1.9

8.6

161

1007

EDC10

NOMESCO Finland

Sagittal osteotomy of ramus of mandible

9.2

8.6

A06AD11

ATC

lactulose; oral

2.4

8.6

354

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

2.9

8.5

187

K07.62

ICD-10 Finland

Habitual dislocation of the jaw joint

13.0

8.4

M01AG02

ATC

tolfenamic acid; oral, rectal

2.1

8.4

512

R03BA01

ATC

beclometasone; inhalant

2.2

8.4

429

N03A

ATC

ANTIEPILEPTICS

+∞

8.4

3540A

ICD-9 Finland

Mononeuritis of upper limb and mononeuritis multiplex, Carpal tunnel syndrome

+∞

8.4

G50

ICD-10 Finland

Disorders of trigeminal nerve

+∞

8.4

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

2.9

8.3

184

R50.9

ICD-10 Finland

Fever, unspecified

2.3

8.3

366

M01AB55

ATC

diclofenac, combinations; oral

3.0

8.3

166

SFC01

NOMESCO Finland

Adjuvant procedure of filling therapy

1.9

8.2

146

892

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

2.8

8.1

199

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

2.6

8.1

255

K30

ICD-10 Finland

Functional dyspepsia

2.5

8.1

275

N02CC04

ATC

rizatriptan; oral

3.1

8.1

146

NA1AD

NOMESCO Finland

Cervical spine CT examination

4.0

8.1

M50.3

ICD-10 Finland

Other cervical disc degeneration

6.5

8.1

W0A10

NOMESCO Finland

Mapping of psychosocial situation

22.4

8.0

NE1BG

NOMESCO Finland

Pelvic, hip and femur MRI examination with high intensity magnet

4.9

8.0

F33.10

ICD-10 Finland

Recurrent depression, moderate episode without somatic syndrome

3.5

8.0

108

N02AB03

ATC

fentanyl; nasal, sublingual, transdermal

4.5

7.9

M01AH01

ATC

celecoxib; oral (coxibs)

2.1

7.9

102

552

J01DA01

ATC

[U] cefalexin; systemic

1.7

7.9

320

2515

R10.1

ICD-10 Finland

Pain localized to upper abdomen

2.1

7.9

521

M03BA52

ATC

carisoprodol, combinations excl. psycholeptics; oral

3.9

7.9

J01DA06

ATC

[U] cefuroxime; systemic

2.2

7.9

448

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

3.1

7.9

152

J05AB01

ATC

aciclovir; systemic

1.9

7.9

121

703

SPAT1263

SPAT

Sampling

1.7

7.9

216

1515

G56.2

ICD-10 Finland

Lesion of ulnar nerve

11.0

7.8

Z76.9

ICD-10 Finland

Person encountering health services in unspecified circumstances

2.9

7.8

174

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

2.9

7.8

168

EB1MA

NOMESCO Finland

Cephalometry with X-ray

6.5

7.8

Z04.3

ICD-10 Finland

Examination and observation following other accident

6.5

7.8

WX290

NOMESCO Finland

Other blockade of nerve

1.7

7.8

219

1546

M48.0

ICD-10 Finland

Spinal stenosis

2.5

7.7

270

A03FA01

ATC

metoclopramide; systemic, rectal

1.9

7.7

118

680

R03DC03

ATC

montelukast; oral

2.1

7.7

489

NB1BA

NOMESCO Finland

Shoulder extensive X-ray examination without contrast

4.3

7.7

DNB20

NOMESCO Finland

Endoscopic ethmoidectomy

5.3

7.6

K07.58

ICD-10 Finland

Other abnormal function of teeth and jaws

18.7

7.6

SGA02

NOMESCO Finland

Opening and dilatation of root canal of tooth

2.3

7.6

332

R13

ICD-10 Finland

Dysphagia

3.1

7.6

141

H53.1

ICD-10 Finland

Subjective visual disturbances

3.0

7.6

151

ZXC10

NOMESCO Finland

Use of laser

4.8

7.6

H02AB07

ATC

prednisone; oral

2.2

7.6

425

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

4.0

7.6

K04.4

ICD-10 Finland

Acute apical periodontitis of pulpal origin

2.7

7.6

208

K14.60

ICD-10 Finland

Glossopyrosis

10.2

7.6

J31.0

ICD-10 Finland

Chronic rhinitis

2.8

7.6

175

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.8

7.5

145

909

UKC02

NOMESCO Finland

Cystoscopy

2.2

7.5

386

Z01.2

ICD-10 Finland

Dental examination

1.7

7.5

213

1503

J02AC01

ATC

fluconazole; systemic

1.7

7.5

224

1605

SPAT1104

SPAT

Monitoring of emergency patient

2.9

7.5

154

EGA00

NOMESCO Finland

Arthroscopy of mandibular joint

81.2

7.4

XX2XT

NOMESCO Finland

Other injection with other radiological guidance

81.2

7.4

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.0

7.4

104

582

EFB40

NOMESCO Finland

Removal of internal or external fixation device from facial bones

13.6

7.4

L08

ICPC

Shoulder symptom/complaint

2.0

7.4

535

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

3.0

7.4

149

N05CD07

ATC

temazepam; oral

2.3

7.4

310

J05AB11

ATC

valaciclovir; oral

2.2

7.4

372

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.5

7.4

255

R06AE07

ATC

cetirizine; oral

1.7

7.3

232

1689

G51.8

ICD-10 Finland

Other disorders of facial nerve

+∞

7.3

EB1BA

NOMESCO Finland

Extensive intraoral X-ray examination

16.0

7.3

Z50.1

ICD-10 Finland

Other physical therapy

3.6

7.2

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.6

7.2

292

2266

X59

ICD-10 Finland

Exposure to unspecified factor

2.0

7.2

518

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

2.9

7.2

153

EEC05

NOMESCO Finland

Le Fort I osteotomy

20.3

7.2

SGB30

NOMESCO Finland

Other demanding filling of root channel of tooth

2.3

7.1

309

J01DA09

ATC

[U] cefadroxil; inhalant, oral

1.8

7.1

136

849

H03AA01

ATC

levothyroxine sodium; systemic

1.8

7.0

132

818

H92.0

ICD-10 Finland

Otalgia

3.1

7.0

126

SXC02

NOMESCO Finland

Other oral or dental procedure, restricted

4.2

7.0

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

2.5

7.0

219

SPAT1295

SPAT

Other function in accordance with physical therapy nomenclature

3.1

7.0

121

N06AB04

ATC

citalopram; systemic

1.9

6.9

117

698

C10AA05

ATC

atorvastatin; oral

1.7

6.9

172

1162

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

4.5

6.9

EN1AD

NOMESCO Finland

CT examination of mouth and soft tissues of neck

14.0

6.9

L01

ICPC

Neck symptom/complaint

2.2

6.9

363

G44.8

ICD-10 Finland

Other specified headache syndromes

8.4

6.9

SPAT1215

SPAT

Assessment of need for medical rehabilitation

3.3

6.8

100

SJX21

NOMESCO Finland

Therapeutic intervention or check-up related to orthodontic treatment

11.1

6.8

SPAT1296

SPAT

Other function in accordance with occupational therapy nomenclature

11.1

6.8

S01GX01

ATC

cromoglicic acid; ophthalmic

1.9

6.8

116

693

K04.0

ICD-10 Finland

Pulpitis

2.3

6.8

289

F32.11

ICD-10 Finland

Moderate depressive episode with somatic syndrome

4.2

6.8

M01AE01

ATC

ibuprofen; systemic, rectal

2.0

6.8

461

4120

R06.5

ICD-10 Finland

Mouth breathing

2.7

6.8

171

T88.8

ICD-10 Finland

Other specified complications of surgical and medical care, not elsewhere classified

40.6

6.8

R07.3

ICD-10 Finland

Other chest pain

2.4

6.8

236

R51

ICD-10 Finland

Headache

3.1

6.7

118

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

2.2

6.7

319

K04.09

ICD-10 Finland

Pulpit UNS

3.6

6.7

EG1CG

NOMESCO Finland

Extensive MRI examination of mandipular joint with high intensity magnet

22.8

6.7

EB1WA

NOMESCO Finland

22.8

6.7

L28

ICPC

Limited function/disability (L)

2.1

6.7

390

7890A

ICD-9 Finland

Other symptoms involving abdomen and pelvis, Abdominal pain

3.0

6.7

135

N06AA12

ATC

doxepin; systemic

3.0

6.7

135

SJC10

NOMESCO Finland

Orthodontic bandage in one tooth

8.0

6.6

M47.80

ICD-10 Finland

Other spondylosis, multiple sites in spine

4.9

6.6

M51.9

ICD-10 Finland

Intervertebral disc disorder, unspecified

8.9

6.6

M03BC51

ATC

orphenadrine, combinations; systemic

1.7

6.6

154

1019

WZC20

NOMESCO Finland

Multidisciplinary treatment meeting

2.9

6.6

137

K57.3

ICD-10 Finland

Diverticular disease of large intestine without perforation or abscess

2.0

6.6

445

R11

ICD-10 Finland

Nausea and vomiting

2.6

6.6

194

EBB15

NOMESCO Finland

Insertion of dental implant abutment

10.2

6.6

H16.0

ICD-10 Finland

Corneal ulcer

3.3

6.5

D20

ICPC

Mouth/tongue/lip symptom/complaint

3.3

6.5

C08DA01

ATC

verapamil; systemic

3.2

6.5

104

K59.0

ICD-10 Finland

Constipation

3.0

6.5

131

M53.1

ICD-10 Finland

Cervicobrachial syndrome

2.3

6.5

286

XF400

NOMESCO Finland

ECG with 12 standard connections

2.0

6.5

455

SJD10

NOMESCO Finland

Attachment of arrow to fixed orthodontisk device

7.5

6.4

E87.1

ICD-10 Finland

Hypo-osmolality and hyponatraemia

3.5

6.4

A02BC04

ATC

rabeprazole; oral

2.4

6.4

233

L02

ICPC

Back symptom/complaint

2.4

6.4

223

C05AA08

ATC

fluocortolone; rectal, topical

2.1

6.3

385

M54

ICD-10 Finland

Dorsalgia

2.2

6.3

318

EBB10

NOMESCO Finland

Insertion of dental implant

6.1

6.3

SJD40

NOMESCO Finland

Fixation of ready made palatinal or lingual arrow

11.2

6.3

K07.20

ICD-10 Finland

Crossbite (anterior)(posterior)

11.2

6.3

G47.3

ICD-10 Finland

Sleep apnoea

1.9

6.3

537

SGA04

NOMESCO Finland

Very demanding opening and dilatation of root canal of tooth

2.2

6.3

307

H53.2

ICD-10 Finland

Diplopia

4.9

6.3

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.1

6.3

349

ND1AA

NOMESCO Finland

Wrist X-ray examination

2.8

6.3

136

3501A

ICD-9 Finland

Trigeminal nerve disorders, Trigeminal neuralgia

+∞

6.3

G51.9

ICD-10 Finland

Disorder of facial nerve, unspecified

+∞

6.3

35199

ICD-8 Finland

Trigeminal neuralgia

+∞

6.3

3509X

ICD-9 Finland

Trigeminal nerve disorders, Trigeminal nerve disorder, unspecified

+∞

6.3

T78.4

ICD-10 Finland

Allergy, unspecified

3.3

6.3

N83.1

ICD-10 Finland

Corpus luteum cyst

7.2

6.3

EDA10

NOMESCO Finland

Biopsy of mandible

27.0

6.2

EBA12

NOMESCO Finland

Complicated surgical removal of tooth

4.6

6.2

L07

ICPC

Jaw symptom/complaint

6.4

6.2

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

3.7

6.2

SPAT1153

SPAT

Removal of sutures

1.7

6.2

153

1026

G44.0

ICD-10 Finland

Cluster headache syndrome

7.8

6.2

L11

ICPC

Wrist symptom/complaint

2.7

6.1

156

N05BA12

ATC

alprazolam; oral

2.2

6.1

294

N06AB10

ATC

escitalopram; oral

1.8

6.1

107

644

SPAT1260

SPAT

Consultation of another employee

1.9

6.1

505

K60.1

ICD-10 Finland

Chronic anal fissure

5.0

6.1

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.7

6.1

133

863

NBG15

NOMESCO Finland

Acromioplastia, arthroscopic

2.8

6.1

133

SJD20

NOMESCO Finland

Attachment of modifiable arrow of fixed orthodontisk device

6.8

6.1

G35

ICD-10 Finland

Multiple sclerosis

6.8

6.1

M65.3

ICD-10 Finland

Trigger finger

4.1

6.1

Z03.80

ICD-10 Finland

Observation for other suspected diseases and conditions

4.1

6.1

SFA30

NOMESCO Finland

Filling on tree or more surfaces of tooth

1.6

6.1

202

1467

K07.68

ICD-10 Finland

Other disorders of the jaw joint

10.2

6.1

EP1CG

NOMESCO Finland

Extensive MRI examination of soft tissue of neck with high intesity magnet

10.2

6.1

SJD00

NOMESCO Finland

Removal or reattacment of arrow in fixed orthodontisk device

6.1

6.0

F61.0

ICD-10 Finland

Mixed personality disorders

5.7

6.0

J01AA07

ATC

tetracycline; systemic

1.9

6.0

461

NAME	G6_TRIOTHUNS
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G50[8-9]
HD_ICD_9	350[8-9]
HD_ICD_8	35601
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G50[8-9]
COD_ICD_9	350[8-9]
COD_ICD_8	35601
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
G6_TRIOTHUNS	1.485 [1.28, 1.73]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.513

Parameter	HR [95% CI]	p-value
G6_TRIOTHUNS	1.674 [1.35, 2.07]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.003

N-year risk	Females	Males
1	0.131%	0.338%
5	0.889%	1.895%
10	2.321%	4.687%
15	4.569%	8.682%
20	7.835%	14.589%

Other and unspecified trigeminal disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints