Risteys · M13_VERTEBCOLLAPSE

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M48.5 Cause of death: ICD-10 — M48.5 2 out of 7 registries used, show all original rules.	271
4. Check minimum number of events None	271
5. Include endpoints None	271
6. Filter based on genotype QC (FinnGen only)	271

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2977	1951	1011
Only index persons	2606	1732	874
Unadjusted period prevalence (%)
Whole population	0.05	0.06	0.03
Only index persons	0.05	0.06	0.03
Median age at first event (years)
Whole population	76.32	78.64	71.80
Only index persons	76.04	78.45	71.27

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	271	178	93
Unadjusted period prevalence (%)	0.05	0.06	0.04
Median age at first event (years)	73.22	74.06	71.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
243: Matched controls
2428

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M48.5

ICD-10 Finland

Collapsed vertebra, not elsewhere classified

+∞

323.0

243

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

24.9

48.1

M54.5

ICD-10 Finland

Low back pain

8.1

43.2

118

252

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

8.7

39.6

175

M48.0

ICD-10 Finland

Spinal stenosis

36.0

36.8

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

39.8

34.5

H05BA01

ATC

calcitonin (salmon synthetic); nasal, parenteral

13.9

33.6

N02AX02

ATC

tramadol; systemic, rectal

5.3

32.5

145

530

M54.9

ICD-10 Finland

Dorsalgia, unspecified

14.8

30.8

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

43.3

30.3

S32.0

ICD-10 Finland

Fracture of lumbar vertebra

19.3

30.0

M80.9

ICD-10 Finland

Unspecified osteoporosis with pathological fracture

24.9

28.5

S22.0

ICD-10 Finland

Fracture of thoracic vertebra

27.0

28.5

N03AX16

ATC

pregabalin; oral

6.1

27.8

207

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

4.5

27.2

152

656

N03AX12

ATC

gabapentin; oral

8.8

26.8

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

32.7

26.2

N02AA05

ATC

oxycodone; systemic

5.5

25.9

234

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

120.4

20.9

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

216.9

19.9

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.6

19.9

150

754

M81.9

ICD-10 Finland

Osteoporosis, unspecified

8.9

19.7

M54.4

ICD-10 Finland

Lumbago with sciatica

8.3

19.2

M05BA04

ATC

alendronic acid; oral

5.1

19.1

169

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.8

18.8

103

396

M80.0

ICD-10 Finland

Postmenopausal osteoporosis with pathological fracture

14.6

18.5

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

8.9

18.0

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

45.8

17.6

M54.6

ICD-10 Finland

Pain in thoracic spine

14.9

17.0

L03

ICPC

Low back symptom/complaint

4.1

16.9

237

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

3.2

16.5

126

608

318

Kela drug reimbursment

Teriparatide

64.5

16.0

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

3.1

15.7

121

584

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

34.2

15.0

M05BX04

ATC

denosumab; parenteral

6.2

14.4

H05AA02

ATC

teriparatide; parenteral

79.7

13.7

A02BC02

ATC

pantoprazole; systemic

3.0

13.7

176

1140

N02AB03

ATC

fentanyl; nasal, sublingual, transdermal

6.4

13.5

N02BE01

ATC

paracetamol; systemic, rectal

4.5

13.5

223

1726

M03BX02

ATC

tizanidine; oral

2.8

13.4

139

781

N02AJ06

ATC

codeine and paracetamol; systemic

3.0

12.4

409

C90.0

ICD-10 Finland

Multiple myeloma

19.3

12.2

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.1

11.8

297

NA3AD

NOMESCO Finland

Lumbar spine and sacrum CT examination

20.2

11.8

L95

ICPC

Osteoporosis

6.9

11.6

C03CA01

ATC

furosemide; systemic

2.6

11.6

129

735

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.8

11.6

468

9732/3-C42.1

ICD-O-3

Plasma cell myeloma of bone marrow

26.5

11.3

X59

ICD-10 Finland

Exposure to unspecified factor

3.3

11.3

226

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

3.3

10.9

218

R53

ICD-10 Finland

Malaise and fatigue

3.0

10.8

306

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.7

10.8

469

C07AB07

ATC

bisoprolol; oral

2.5

10.7

157

1023

153

Kela drug reimbursment

Lenalidomid

62.8

10.7

L04AX04

ATC

lenalidomide; oral

62.8

10.7

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

+∞

10.5

N06AX21

ATC

duloxetine; oral

5.3

10.2

Z01.8

ICD-10 Finland

Other specified special examinations

3.0

10.2

267

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

4.0

10.1

121

M79.6

ICD-10 Finland

Pain in limb

2.6

10.0

453

UJF32

NOMESCO Finland

Coloscopy

2.7

9.9

371

B01AB05

ATC

enoxaparin; parenteral

2.5

9.9

513

M01AH05

ATC

etoricoxib; oral

2.4

9.7

127

764

N06AX11

ATC

mirtazapine; oral

2.6

9.5

453

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

4.6

9.5

A02BC05

ATC

esomeprazole; systemic

2.4

9.5

109

613

M43.1

ICD-10 Finland

Spondylolisthesis

31.4

9.5

NA2BG

NOMESCO Finland

Thoracal spine MRI examination with high intensity magnet

103.9

9.5

M54

ICD-10 Finland

Dorsalgia

4.3

9.4

A02BC01

ATC

omeprazole; systemic

2.5

9.4

483

R07.4

ICD-10 Finland

Chest pain, unspecified

2.6

9.3

434

NE1AA

NOMESCO Finland

Pelvis X-ray examination

4.5

9.3

L02

ICPC

Back symptom/complaint

4.5

9.1

X58

ICD-10 Finland

Exposure to other specified factors

3.8

9.0

117

A49.9

ICD-10 Finland

Bacterial infection, unspecified

3.4

9.0

152

R52.2

ICD-10 Finland

Other chronic pain

9.2

9.0

A02BA02

ATC

ranitidine; systemic

2.7

8.9

325

M01AH02

ATC

rofecoxib; oral

3.1

8.8

194

A02BC03

ATC

lansoprazole; oral

2.5

8.8

453

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

2.8

8.6

267

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

5.0

8.6

M51.8

ICD-10 Finland

Other specified intervertebral disc disorders

93.2

8.5

ABC56

NOMESCO Finland

Decompression of lumbar spinal canal and nerve roots

+∞

8.4

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.9

8.4

224

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

2.4

8.3

477

ZXD05

NOMESCO Finland

Urgent procedure

2.3

8.2

502

XW000

NOMESCO Finland

Bone marrow biopsy

6.3

8.2

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

13.6

8.0

A04AA01

ATC

ondansetron; systemic, rectal

4.5

7.9

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

11.3

7.9

L28

ICPC

Limited function/disability (L)

2.7

7.8

267

D64.9

ICD-10 Finland

Anaemia, unspecified

3.2

7.8

154

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

3.8

7.7

J01DB01

ATC

cefalexin; oral

2.3

7.5

191

1482

Z46.9

ICD-10 Finland

Fitting and adjustment of unspecified device

13.9

7.5

NA2CG

NOMESCO Finland

Thoracal spine extensive MRI examination with high intensity magnet

82.5

7.5

M80.8

ICD-10 Finland

Other osteoporosis with pathological fracture

82.5

7.5

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

3.5

7.3

108

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

3.3

7.3

120

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

5.4

7.3

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.2

7.3

142

M03BC01

ATC

orphenadrine (citrate); systemic

3.0

7.3

166

M47.82

ICD-10 Finland

Other spondylosis, cervical region

16.4

7.3

I48

ICD-10 Finland

Atrial fibrillation and flutter

2.2

7.3

539

H02AB06

ATC

prednisolone; systemic

2.1

7.2

119

759

A28

ICPC

Limited function/disability NOS

2.5

7.2

299

A06AD11

ATC

lactulose; oral

2.5

7.2

300

R52.9

ICD-10 Finland

Pain, unspecified

3.8

7.0

ZZH21

NOMESCO Finland

Graft of patients own bone, small pieces

14.3

7.0

L86

ICPC

Back syndrome with radiating pain

6.4

6.9

N05BA04

ATC

oxazepam; oral

2.3

6.9

380

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.7

6.8

220

M80.5

ICD-10 Finland

Idiopathic osteoporosis with pathological fracture

41.2

6.8

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

5.3

6.7

AA1AD

NOMESCO Finland

CT of head and brain

2.2

6.6

437

NA1AD

NOMESCO Finland

Cervical spine CT examination

6.0

6.6

S22.3

ICD-10 Finland

Fracture of rib

3.8

6.6

D07AC01

ATC

betamethasone; topical

2.1

6.5

520

I25.1

ICD-10 Finland

Atherosclerotic heart disease

2.2

6.5

433

M80.4

ICD-10 Finland

Drug-induced osteoporosis with pathological fracture

71.7

6.5

NA3DG

NOMESCO Finland

Lumbar spine very extensive MRI examination with high intensity magnet

71.7

6.5

NAG62

NOMESCO Finland

Posterior fusion of lumbar spine with fixation, 2-3 vertebraea

+∞

6.3

N30.0

ICD-10 Finland

Acute cystitis

2.6

6.2

212

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

3.9

6.2

N03AE01

ATC

clonazepam; systemic

4.4

6.2

G04CA02

ATC

tamsulosin; oral

2.4

6.2

277

ZX120

NOMESCO Finland

Intravenous

3.1

6.1

112

R10.1

ICD-10 Finland

Pain localized to upper abdomen

2.6

6.1

195

M05BA07

ATC

risedronic acid; oral

4.3

6.1

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

3.7

6.0

M54.8

ICD-10 Finland

Other dorsalgia

7.6

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint M13_VERTEBCOLLAPSE and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_VERTEBCOLLAPSE	1.885 [1.61, 2.21]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.355

During the follow-up period (1.1.1998 — 31.12.2019), 934 out of 1714 females with M13_VERTEBCOLLAPSE died.

Males

Parameter	HR [95% CI]	p-value
M13_VERTEBCOLLAPSE	2.57 [1.93, 3.42]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.008

During the follow-up period (1.1.1998 — 31.12.2019), 507 out of 886 males with M13_VERTEBCOLLAPSE died.

Mortality risk

Mortality risk for people of age

years, who have M13_VERTEBCOLLAPSE.

N-year risk	Females	Males
1	0.216%	0.475%
5	1.281%	3.061%
10	3.045%	7.447%
15	5.762%	13.539%
20	9.692%	22.336%

Relationships between endpoints

↥

Index endpoint: M13_VERTEBCOLLAPSE – Collapsed vertebra, not elsewhere classified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	M13_VERTEBCOLLAPSE
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M485
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M485
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Collapsed vertebra, not elsewhere classified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints