Other bacterial agents as the cause of diseases classified to other chapters

AB1_OTHER_BACT_INOTHER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B96
  • Cause of death: ICD-10 B96

2 out of 7 registries used, show all original rules.

354

4. Check minimum number of events

None

354

5. Include endpoints

None

354

6. Filter based on genotype QC (FinnGen only)

354

Control definitions (FinnGen only)

Control exclude
AB1_BACT_BIR_OTHER_INF_AGENTS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3169 1962 1175
Only index persons 2334 1415 919
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.03
Only index persons 0.05 0.05 0.04
Median age at first event (years)
Whole population 62.07 63.04 60.18
Only index persons 53.67 53.02 54.69

-FinnGen-

Key figures

All Female Male
Number of individuals 354 217 137
Unadjusted period prevalence (%) 0.07 0.07 0.06
Median age at first event (years) 57.16 53.73 62.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
319
Matched controls
3189
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B96.2
ICD-10 Finland
Escherichia coli [E. coli] as the cause of diseases classified to other chapters
+∞
140.2
124
*
B96.5
ICD-10 Finland
Pseudomonas (aeruginosa) as the cause of diseases classified to other chapters
+∞
78.4
72
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
10.3
64.3
148
247
B96.1
ICD-10 Finland
Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
+∞
43.8
41
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
20.4
41.5
63
38
J01MA02
ATC
ciprofloxacin; systemic
4.2
31.9
191
839
A41.8
ICD-10 Finland
Other specified sepsis
27.9
25.9
35
14
B96.88
ICD-10 Finland
Other specified bacterial agents as the cause of diseases classified to other chapters
+∞
23.2
22
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.3
23.2
77
179
A41.9
ICD-10 Finland
Sepsis, unspecified
11.2
22.9
44
45
J01MA12
ATC
levofloxacin; systemic
3.9
21.6
104
348
R50.9
ICD-10 Finland
Fever, unspecified
4.3
21.0
89
265
B96.80
ICD-10 Finland
Campylo bacterial infection causing disease classified in other paragraph
+∞
18.9
18
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.8
18.4
90
300
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.4
16.3
44
78
J01EA01
ATC
trimethoprim; systemic
2.8
15.5
127
601
J01GB01
ATC
tobramycin; inhalant, parenteral
+∞
14.7
14
*
B96.0
ICD-10 Finland
Mycoplasma pneumoniae [M. pneumoniae] as the cause of diseases classified to other chapters
+∞
14.7
14
*
B99
ICD-10 Finland
Other and unspecified infectious diseases
14.5
13.9
23
17
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
13.5
109
503
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
10.7
13.2
25
25
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
13.1
95
410
C03CA01
ATC
furosemide; systemic
2.5
12.9
131
686
127
Kela drug reimbursment
Transplant complication
12.3
12.5
22
19
J01FF01
ATC
clindamycin; systemic
2.7
12.5
108
516
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
10.3
12.5
24
25
A11CC03
ATC
alfacalcidol; systemic
9.3
12.3
25
29
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
12.0
81
333
J47
ICD-10 Finland
Bronchiectasis
13.2
11.8
20
16
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.4
11.5
23
26
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.8
11.4
38
87
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
6.3
11.4
30
52
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.9
11.3
37
83
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
11.1
65
241
ZX120
NOMESCO Finland
Intravenous
3.9
11.1
47
136
TK800
NOMESCO Finland
Hemodialysis
10.1
10.9
21
22
J01MA06
ATC
norfloxacin; oral
3.0
10.8
67
256
UKC02
NOMESCO Finland
Cystoscopy
2.9
10.6
71
289
J01MA14
ATC
moxifloxacin; systemic
3.8
10.2
43
124
TQW11
NOMESCO Finland
Vacuum treatment of wound
10.5
9.6
18
18
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.6
9.6
33
78
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
9.6
65
264
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.3
9.5
35
89
B96.7
ICD-10 Finland
Clostridium perfringens [C. perfringens] as the cause of diseases classified to other chapters
+∞
9.4
9
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.8
9.3
40
117
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
9.3
123
708
B03XA02
ATC
darbepoetin alfa; parenteral
9.5
9.2
18
20
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.9
9.0
37
104
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.2
9.0
47
161
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
8.8
152
976
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
6.7
8.6
21
33
L04AD01
ATC
ciclosporin; systemic
8.2
8.5
18
23
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
5.1
8.5
26
55
XF400
NOMESCO Finland
ECG with 12 standard connections
2.5
8.4
72
333
L04AA06
ATC
mycophenolic acid; systemic
8.9
8.4
17
20
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.5
8.4
69
312
J01XE01
ATC
nitrofurantoin; oral
7.4
8.4
19
27
N18.8
ICD-10 Finland
Other chronic renal failure
6.6
8.2
20
32
Z94.0
ICD-10 Finland
Kidney transplant status
12.1
8.1
14
12
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.0
8.1
32
87
L04AA01
ATC
[U] ciclosporin; systemic
9.3
8.1
16
18
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
10.4
8.1
15
15
J01MA01
ATC
ofloxacin; systemic
3.2
8.0
44
153
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
5.2
7.8
23
47
QBB99
NOMESCO Finland
Other procedure for wound of skin of trunk
46.1
7.7
9
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.4
7.5
35
110
J01CA08
ATC
pivmecillinam; oral
2.0
7.5
138
893
H02AB06
ATC
prednisolone; systemic
1.9
7.5
158
1073
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
7.4
103
595
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.1
7.4
41
144
A12AA04
ATC
calcium carbonate; oral
9.7
7.4
14
15
J01XB01
ATC
colistin; inhalant, parenteral
+∞
7.3
7
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
16.2
7.3
11
7
R03AK11
ATC
formoterol and fluticasone; inhalant
8.2
7.2
15
19
L89
ICD-10 Finland
Decubitus ulcer and pressure area
6.3
7.2
18
30
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.4
7.1
34
109
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
7.1
98
563
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
7.1
62
289
Z49.1
ICD-10 Finland
Extracorporeal dialysis
10.4
7.1
13
13
J01DA01
ATC
[U] cefalexin; systemic
1.9
6.8
201
1517
N30.9
ICD-10 Finland
Cystitis, unspecified
3.3
6.8
33
108
J02AC01
ATC
fluconazole; systemic
1.9
6.7
122
776
H02AB07
ATC
prednisone; oral
2.5
6.7
55
249
TKC20
NOMESCO Finland
Catheterisation of bladder
3.3
6.7
33
109
N06AX21
ATC
duloxetine; oral
2.9
6.7
40
151
N03AX16
ATC
pregabalin; oral
2.1
6.7
85
472
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
6.6
42
163
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
6.5
163
1155
J45.9
ICD-10 Finland
Asthma, unspecified
2.3
6.5
66
329
WW500
NOMESCO Finland
Blood transfusion
4.5
6.4
21
49
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.2
6.3
69
355
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
18.5
6.3
9
5
U88
ICD-10 Finland
Agent resistant to multiple antibiotics
+∞
6.3
6
*
G04AC01
ATC
NA
4.4
6.2
21
50
L04AX01
ATC
azathioprine; systemic
4.0
6.2
23
60
J01XX05
ATC
methenamine; oral
7.9
6.2
13
17
M04AA01
ATC
allopurinol; systemic
2.4
6.2
53
243
A10AA02
ATC
NA
5.1
6.1
18
37
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.3
6.1
21
51
TPH05
NOMESCO Finland
Open cannulation of peripheral vein
12.8
6.1
10
8
H02AB04
ATC
methylprednisolone; systemic
2.3
6.1
56
268
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
6.9
6.1
14
21
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.2
6.1
64
325
N02AX02
ATC
tramadol; systemic, rectal
1.8
6.0
130
873

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
171
755
3.45
28.89
10.8
4.2
—
—
—
0
0
32
34
10.25
27.48
9.1
2.9
—
—
—
0
0
100
436
2.80
15.67
7.6
4.3
0.8
0.8
mmol/l
0.15
91
410
63
216
3.33
15.00
3.7
2.9
9.5
10.1
g/l
0.54
57
199
160
904
2.40
14.39
13.4
6.2
—
—
—
0
0
196
1233
2.32
13.48
13.8
6.3
0.6
0.6
%
0.37
186
1154
53
180
3.29
12.74
2.9
1.7
1.5
1.8
g/l
0.19
46
164
199
1280
2.27
12.72
14.1
6.5
8.5
8.5
%
0.07
189
1210
198
1273
2.26
12.65
13.7
6.2
2.5
2.8
%
1.52
187
1192
76
319
2.76
12.57
3.3
1.8
—
—
—
0
0
21
35
6.32
12.27
6.1
4.0
—
—
—
0
0
86
391
2.58
12.11
4.7
2.3
2.1
2.3
g/l
4.00
79
355
201
1316
2.22
12.08
14.1
6.3
25.5
27.9
%
2.07
190
1238
114
598
2.34
11.70
5.9
2.7
494.7
558.1
mosm/kgh2o
2.76
97
506
198
1304
2.18
11.53
13.2
6.1
60.7
57.1
%
3.57
185
1233
82
373
2.56
11.48
5.1
2.4
16.5
22.4
%
5.48
75
327
73
322
2.60
10.85
4.3
3.2
1.9
1.8
%
0.18
62
297
14
5
29.05
10.80
2.6
3.2
0.9
1.1
mg/l
—
9
5
56
219
2.85
10.49
8.8
3.6
131.6
75.5
ng/l
3.03
47
200
135
789
2.15
10.44
6.3
3.0
—
—
—
0
0
215
1497
2.11
10.42
11.0
6.4
10.1
11.3
umol/l
1.27
200
1407
180
1177
2.08
10.29
8.9
4.8
32.7
35.5
g/l
6.30
161
1106
64
272
2.65
10.22
9.0
4.3
1.4
1.8
mmol/l
0.36
57
210
86
421
2.38
10.18
3.8
1.9
—
—
—
0
0
23
50
4.85
10.15
6.7
3.3
51.8
60.0
%
2.21
23
50
137
814
2.11
10.08
6.4
3.1
0.6
0.5
e6/l
0.05
114
610
58
237
2.73
9.99
17.2
9.5
—
—
—
0
0
200
1375
2.04
9.80
13.0
6.0
0.0
0.0
e9/l
0.09
181
1191
225
1620
2.07
9.63
16.4
9.4
4.5
4.1
e9/l
1.63
201
1418
203
1411
2.03
9.56
13.7
6.3
0.2
0.2
e9/l
0.23
184
1241
112
628
2.15
9.48
5.2
2.5
5.5
6.6
e6/l
0.29
98
555
198
1369
2.01
9.41
13.1
6.0
0.6
0.6
e9/l
1.68
179
1184
145
898
2.04
9.40
6.6
3.2
27.3
133.8
e6/l
0.85
120
695
201
1413
1.98
8.93
13.5
6.0
1.7
1.8
e9/l
1.57
184
1244
55
233
2.61
8.79
5.0
3.0
76.2
73.0
e9/l
0.11
38
177
15
25
6.22
8.72
1.2
1.2
0.4
0.4
g/l
—
10
20
15
25
6.22
8.72
1.2
1.2
2.4
2.6
g/l
—
10
20
51
209
2.68
8.70
5.7
4.9
0.3
0.1
%
0.33
26
65
49
200
2.68
8.42
5.7
4.6
0.8
0.4
%
0.87
22
49
197
1395
1.93
8.36
16.7
6.8
1.2
1.2
mmol/l
0.37
162
1171
68
328
2.33
8.20
2.5
1.4
—
—
—
0
0
34
119
3.05
7.72
2.2
2.2
1.7
1.5
g/l
0.33
28
102
44
179
2.67
7.60
3.6
2.6
—
—
—
0
0
27
83
3.44
7.55
2.6
4.4
251.4
30.1
mg/l
0.48
20
65
51
224
2.49
7.54
3.6
3.1
64.5
66.2
g/l
0.84
45
204
67
334
2.24
7.45
5.2
3.1
7.9
8.6
umol/l
0.12
53
291
107
637
1.97
7.45
1.7
1.4
2.3
2.4
g/l
0.17
72
378
23
64
3.77
7.43
2.2
1.8
—
—
—
0
0
144
947
1.88
7.42
4.7
3.2
—
—
—
0
0
51
227
2.46
7.33
5.8
4.7
0.9
0.9
%
0.04
26
74
14
26
5.57
7.31
1.2
1.2
—
—
—
0
0
48
208
2.51
7.30
9.4
5.4
7.4
7.4
ph
0.16
11
24
48
209
2.50
7.22
9.4
5.3
5.1
5.1
kpa
0.01
48
197
154
1042
1.85
7.20
7.7
3.8
50.9
91.5
e6/l
1.22
125
744
26
83
3.30
6.86
2.7
4.4
51.7
61.4
mg/l
0.19
20
65
56
269
2.29
6.77
3.6
2.2
0.2
0.2
g/l
0.22
51
252
20
54
3.87
6.73
2.0
1.6
—
—
—
0
0
45
198
2.46
6.62
6.2
5.0
0.0
0.2
%
0.35
22
55
173
1239
1.78
6.51
4.8
2.7
198.1
109.3
ug/l
1.67
151
1138
161
1135
1.77
6.35
16.2
9.1
1.3
1.2
inr
0.88
55
344
20
57
3.66
6.25
8.3
2.6
—
—
—
0
0
217
1677
1.76
6.11
9.1
4.9
6.9
6.7
mmol/l
0.63
206
1542
22
69
3.33
5.98
1.4
1.2
—
—
—
0
0
37
157
2.52
5.87
1.3
1.3
—
—
—
0
0
155
1105
1.72
5.71
2.2
2.0
88.5
95.8
pmol/l
1.25
80
549
20
61
3.42
5.67
2.5
5.0
—
—
—
0
0
19
56
3.53
5.67
5.3
3.1
—
—
—
0
0
9
7
13.15
5.61
1.9
1.1
—
—
—
0
0
130
896
1.71
5.34
4.5
2.4
—
—
—
0
0
9
8
11.50
5.32
2.0
2.0
—
—
—
0
0
20
64
3.25
5.27
6.3
2.3
15.5
15.6
%
0.05
15
30
258
2138
1.76
5.26
16.3
7.5
92.1
79.6
u/l
2.09
242
1990
26
98
2.78
5.20
7.3
6.9
8.2
8.5
kpa
0.45
26
89
85
525
1.81
5.08
1.9
1.7
952.8
1236.4
nmol/l
2.57
55
395
170
1273
1.65
5.01
15.9
6.3
1.2
1.2
mmol/l
1.26
155
1153
16
46
3.60
4.95
1.3
1.9
0.5
0.9
g/l
0.89
11
41
126
881
1.67
4.81
4.5
2.5
51.6
55.3
u/l
0.50
118
813
63
360
1.91
4.78
25.5
21.3
1.4
1.3
inr
0.17
11
52
123
857
1.67
4.75
11.3
3.8
7.4
7.4
ph
0.17
34
172
117
807
1.67
4.69
4.7
4.0
—
—
—
0
0
12
29
4.25
4.66
1.2
1.4
—
—
—
0
0
232
1904
1.63
4.54
8.3
4.8
8404.8
1957.4
e6/l
—
5
34
16
50
3.30
4.39
9.3
2.6
—
—
—
0
0
246
2057
1.64
4.38
7.0
4.1
20.5
11.7
mm/h
6.35
223
1882
107
734
1.66
4.33
3.4
2.0
3.5
3.1
mg/l
0.66
93
629
13
36
3.71
4.24
2.1
1.2
—
—
—
0
0
98
661
1.67
4.22
4.4
2.7
362.2
5882.3
umol/l
2.63
83
568
9
13
7.07
4.18
3.7
2.4
—
—
—
0
0
36
176
2.16
4.17
4.4
2.1
3.9
4.2
e9/l
0.26
22
137
12
32
3.85
4.12
2.3
2.7
—
—
—
0
0
21
82
2.66
3.96
8.2
3.1
—
—
—
0
0
94
640
1.64
3.87
4.7
2.0
1.3
1.3
mg/l
0.06
75
495
11
29
3.88
3.83
2.2
2.1
31.9
32.8
pg
0.31
11
29
11
29
3.88
3.83
1.1
1.2
—
—
—
0
0
7
8
8.90
3.79
1.6
1.5
—
—
—
0
0
56
332
1.82
3.78
2.2
1.6
—
—
—
0
0
233
1960
1.55
3.71
8.3
4.5
—
—
—
0
0
13
40
3.34
3.66
2.8
1.7
88.4
90.5
%
0.34
13
40
100
701
1.59
3.63
11.9
7.4
—
—
—
0
0
44
245
1.91
3.60
2.0
1.4
—
—
—
0
0
7
9
7.91
3.57
1.6
2.4
—
—
—
0
0
79
527
1.64
3.50
2.3
1.9
—
—
—
0
0
16
58
2.84
3.47
6.8
3.2
—
—
—
0
0
31
155
2.10
3.42
10.5
6.0
—
—
—
0
0
15
53
2.91
3.40
2.5
1.8
—
—
—
0
0
62
391
1.71
3.39
1.2
1.3
—
—
—
0
0
10
27
3.78
3.37
1.9
1.8
—
—
—
0
0
11
33
3.41
3.22
7.5
2.6
—
—
—
0
0
165
1317
1.47
3.20
6.2
4.1
—
—
—
0
0
159
1260
1.48
3.20
22.1
10.2
0.0
0.0
e9/l
0.61
136
1031
37
204
1.91
3.13
1.9
1.5
—
—
—
0
0
42
242
1.83
3.11
2.3
2.4
20.1
7.6
ug/l
0.60
31
211
125
949
1.49
3.09
4.0
3.3
2.3
2.4
mmol/l
1.21
103
828
68
450
1.63
3.09
5.8
3.0
30.7
29.9
s
0.44
63
438
49
297
1.75
3.08
13.0
8.1
1.1
1.2
mmol/l
0.06
39
239
49
297
1.75
3.08
13.0
8.0
11.5
11.8
kpa
0.17
44
286
172
1393
1.46
3.05
6.0
3.9
0.0
0.0
estimate
0.00
39
289
19
81
2.42
3.04
1.3
1.5
222.8
263.1
ug/g
—
10
47
172
1402
1.44
2.90
8.3
5.2
0.0
0.0
estimate
0.00
40
288
173
1420
1.43
2.77
6.1
4.0
0.0
0.0
estimate
0.50
40
282
55
357
1.64
2.70
3.3
2.2
161.9
136.9
ug/g
0.19
42
273
87
629
1.51
2.69
8.5
4.8
—
—
—
0
0
90
658
1.49
2.63
1.7
1.6
19.9
21.0
nmol/l
0.24
74
552
21
103
2.10
2.47
2.2
2.0
—
—
—
0
0
10
35
2.91
2.32
1.2
1.3
—
—
—
0
0
64
447
1.53
2.31
2.3
1.6
—
—
—
0
0
26
143
1.88
2.26
5.8
3.7
—
—
—
0
0
87
653
1.44
2.20
5.0
3.8
—
—
—
0
0
8
24
3.39
2.19
3.3
2.6
—
—
—
0
0
5
10
5.05
2.07
1.0
1.3
—
—
—
0
0
5
10
5.05
2.07
1.0
1.0
—
—
—
0
0
133
1085
1.36
2.05
5.1
3.9
31.7
41.9
ng/l
0.90
105
771
6
15
4.05
2.04
2.0
1.9
—
—
—
0
0
8
26
3.12
2.02
1.9
1.0
—
—
—
0
0
40
261
1.60
1.95
9.3
3.5
—
—
—
0
0
8
27
3.01
1.94
2.5
1.4
—
—
—
0
0
8
27
3.01
1.94
9.0
2.5
—
—
—
0
0
9
33
2.77
1.94
1.0
1.2
—
—
—
0
0
18
92
2.01
1.93
1.4
1.7
—
—
—
0
0
10
39
2.61
1.93
3.8
3.3
—
—
—
0
0
72
537
1.43
1.88
4.5
3.8
133.5
283.8
ng/l
0.72
65
420
9
36
2.54
1.75
2.1
1.8
—
—
—
0
0
9
36
2.54
1.75
2.1
1.8
—
—
—
0
0
9
36
2.54
1.75
2.1
1.8
—
—
—
0
0
9
36
2.54
1.75
2.1
1.8
—
—
—
0
0
38
252
1.57
1.74
9.3
4.4
—
—
—
0
0
8
30
2.70
1.73
1.1
1.2
—
—
—
0
0
7
24
2.95
1.73
1.1
1.1
—
—
—
0
0
5
13
3.88
1.72
1.0
1.5
—
—
—
0
0
10
42
2.42
1.69
2.5
2.7
—
—
—
0
0
107
867
1.34
1.68
3.7
2.1
106.4
309.9
u/l
1.88
101
813
7
25
2.84
1.66
1.0
1.0
—
—
—
0
0
5
14
3.61
1.62
1.0
2.4
—
—
—
0
0
5
14
3.61
1.62
4.2
1.6
1321.8
905.8
u/ml
—
5
14
10
43
2.36
1.61
2.5
2.7
104.7
106.0
mmol/l
—
10
43
10
43
2.36
1.61
2.5
2.7
4.1
4.0
mmol/l
—
10
43
129
1082
1.30
1.57
2.5
2.1
—
—
—
0
0
8
33
2.46
1.54
1.0
1.0
—
—
—
0
0
8
33
2.46
1.54
1.3
1.1
—
—
—
0
0
27
170
1.64
1.54
3.3
3.5
4.4
4.6
pmol/l
0.68
22
148
12
58
2.11
1.51
2.7
2.3
—
—
—
0
0
9
38
2.40
1.46
3.3
1.4
—
—
—
0
0
15
85
1.80
1.25
9.2
4.2
—
—
—
0
0
6
25
2.42
1.25
1.8
3.1
—
—
—
0
0
33
231
1.47
1.23
2.0
1.5
—
—
—
0
0
17
101
1.72
1.22
1.2
1.2
—
—
—
0
0
67
531
1.32
1.22
3.7
2.9
2.4
2.5
mmol/l
0.13
53
466
47
354
1.38
1.18
1.5
1.3
337.8
529.4
titre
—
9
81
0
33
0.00
1.16
0.0
1.5
—
275.0
—
0
23
292
2769
1.31
1.14
43.4
14.7
31.0
23.1
mg/l
3.17
268
2193
26
177
1.51
1.11
3.9
4.4
—
—
—
0
0
264
2476
1.26
1.10
38.0
15.7
37.3
39.4
%
2.86
175
1774
21
137
1.57
1.08
24.6
10.9
—
—
—
0
0
28
196
1.47
1.06
2.5
3.0
—
—
—
0
0
7
34
2.08
1.03
1.4
1.3
—
—
—
0
0
33
444
0.72
1.03
3.2
3.0
1.6
0.7
ug/l
0.36
22
301
16
99
1.65
1.01
1.4
1.4
—
—
—
0
0
7
35
2.02
1.00
1.1
1.3
—
—
—
0
0
9
49
1.86
0.99
1.7
1.5
—
—
—
0
0
9
49
1.86
0.99
3.2
1.5
—
—
—
0
0
0
29
0.00
0.98
0.0
3.1
—
—
—
0
0
247
2616
0.82
0.97
5.0
4.5
6.0
5.9
mmol/l
0.50
213
2368
13
209
0.61
0.97
1.1
1.3
—
—
—
0
0
39
299
1.34
0.91
3.4
3.8
68.6
42.8
ug/l
0.15
33
251
93
798
1.22
0.90
6.5
3.5
—
—
—
0
0
8
45
1.80
0.85
1.3
1.2
—
—
—
0
0
25
180
1.42
0.84
1.3
1.2
—
—
—
0
0
82
699
1.23
0.84
1.2
1.3
0.5
1.5
u/ml
1.99
15
193
23
163
1.44
0.84
4.6
3.1
0.0
0.1
e6/l
1.27
23
158
44
350
1.29
0.81
1.3
1.3
—
—
—
0
0
94
816
1.21
0.81
4.7
3.2
6.3
7.5
mmol/l
1.49
70
689
6
33
1.83
0.79
1.8
1.3
—
—
—
0
0
6
33
1.83
0.79
3.0
1.8
—
—
—
0
0
90
780
1.21
0.79
5.7
4.0
20.3
9.3
mg/mmol
1.03
54
501
0
28
0.00
0.76
0.0
1.7
—
—
—
0
0
5
24
2.10
0.75
1.8
1.3
—
—
—
0
0
9
55
1.65
0.74
1.3
1.9
—
—
—
0
0
54
447
1.25
0.73
1.4
1.3
27.1
32.8
iu/ml
0.25
24
147
7
42
1.68
0.68
2.0
1.5
—
—
—
0
0
5
27
1.86
0.68
1.0
1.0
—
—
—
0
0
176
1889
0.86
0.68
5.1
3.8
—
—
—
0
0
7
43
1.64
0.67
2.0
7.6
5.5
6.3
mmol/l
—
7
36
11
70
1.59
0.66
1.4
2.0
9.4
11.4
mg/l
0.46
11
65
5
29
1.73
0.64
1.0
1.4
—
—
—
0
0
69
597
1.19
0.62
1.7
1.7
529.1
13481348.7
pmol/l
0.50
54
497
299
3074
0.82
0.62
51.4
21.3
7.4
6.7
e9/l
2.63
292
2968
299
3073
0.83
0.60
51.3
21.3
4.3
4.5
e12/l
9.42
292
2969
299
3073
0.83
0.60
51.1
21.2
30.0
30.2
pg
1.20
293
3017
0
21
0.00
0.60
0.0
3.9
—
21.2
—
0
16
299
3072
0.83
0.59
51.2
21.3
91.2
90.9
fl
0.53
293
3017
299
3071
0.83
0.58
51.3
21.3
262.1
251.0
e9/l
1.61
292
2978
15
107
1.42
0.56
5.9
4.0
0.7
0.2
g/l
—
10
51
6
37
1.63
0.56
1.2
1.0
—
—
—
0
0
84
749
1.16
0.54
4.5
3.3
111.6
302.7
mg/l
0.70
54
489
219
2294
0.88
0.53
42.6
19.0
329.1
332.0
g/l
3.94
213
2276
38
316
1.23
0.52
1.3
1.3
—
—
—
0
0
6
40
1.51
0.52
1.2
1.3
—
75.1
—
0
5
63
716
0.85
0.51
1.8
1.6
1.4
1.3
mmol/l
0.16
50
601
17
128
1.34
0.48
1.1
1.0
—
—
—
0
0
7
47
1.50
0.48
2.1
1.9
4.1
96.9
u/ml
—
7
41
10
142
0.70
0.47
1.3
1.4
—
—
—
0
0
81
897
0.87
0.47
3.3
2.9
—
—
—
0
0
257
2654
0.88
0.44
5.0
4.9
2.6
2.7
mmol/l
0.39
225
2422
5
31
1.62
0.43
1.0
1.4
—
—
—
0
0
14
105
1.35
0.41
4.1
2.6
—
—
—
0
0
0
16
0.00
0.41
0.0
9.1
—
0.6
—
0
16
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
11
80
1.39
0.39
5.5
2.1
129.3
63.5
ug/min
—
6
42
11
80
1.39
0.39
1.3
1.7
—
—
—
0
0
5
36
1.39
0.38
1.6
1.2
—
—
—
0
0
69
758
0.89
0.36
4.3
5.2
5.2
2.7
ug/l
0.28
57
669
9
122
0.73
0.36
2.1
1.7
—
—
—
0
0
251
2582
0.90
0.35
4.7
4.4
1.4
1.5
mmol/l
1.02
220
2362
226
2331
0.92
0.31
45.3
18.0
14.2
13.7
%
5.23
220
2286
84
778
1.10
0.31
1.7
1.5
—
—
—
0
0
49
441
1.13
0.30
1.4
1.3
4.2
9.8
u/ml
0.84
17
181
85
790
1.10
0.29
7.4
4.3
0.0
0.0
estimate
0.00
38
280
27
233
1.17
0.28
3.3
3.7
—
—
—
0
0
288
2824
1.11
0.28
42.6
16.7
139.1
139.6
mmol/l
2.61
282
2735
8
63
1.28
0.28
1.5
1.3
—
—
—
0
0
254
2599
0.92
0.27
4.6
4.4
4.6
4.6
mmol/l
0.17
221
2390
24
207
1.17
0.26
1.5
1.3
—
—
—
0
0
17
143
1.20
0.23
2.5
2.4
—
—
—
0
0
13
107
1.22
0.22
1.3
1.6
—
—
—
0
0
13
107
1.22
0.22
1.3
1.6
—
—
—
0
0
59
634
0.92
0.21
5.7
4.3
1.0
1.0
kg/l
—
8
85
0
11
0.00
0.21
0.0
4.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
4.0
—
—
—
0
0
13
108
1.21
0.20
1.3
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
25
281
0.88
0.20
2.0
1.8
—
—
—
0
0
287
2827
1.08
0.20
43.7
16.8
4.0
4.0
mmol/l
3.09
281
2736
28
252
1.12
0.18
1.9
1.5
—
—
—
0
0
8
70
1.15
0.16
1.5
2.1
—
—
—
0
0
15
130
1.16
0.16
1.1
1.2
—
—
—
0
0
6
78
0.77
0.15
1.2
1.3
—
—
—
0
0
12
102
1.18
0.15
1.0
1.1
—
—
—
0
0
285
2884
0.94
0.15
33.4
13.6
—
—
—
0
0
7
87
0.80
0.14
19.9
11.1
—
—
—
0
0
245
2486
0.95
0.13
4.4
3.9
1.4
1.2
mmol/l
1.85
213
2263
18
197
0.91
0.10
1.4
1.3
18.0
140.1
iu/ml
—
6
73
12
106
1.14
0.10
1.1
1.6
—
—
—
0
0
6
57
1.05
0.08
1.2
3.0
22.3
29.3
u/ml
—
6
57
28
295
0.94
0.06
1.8
1.7
—
—
—
0
0
9
104
0.86
0.06
1.0
1.1
—
—
—
0
0
12
109
1.10
0.06
2.3
1.6
14.4
23.6
iu/l
—
7
93
24
251
0.95
0.04
1.1
1.2
—
—
—
0
0
11
101
1.09
0.04
1.3
1.7
—
—
—
0
0
15
152
0.99
0.00
1.9
3.1
106.9
39.1
u/ml
0.76
15
147
246
2458
1.00
0.00
7.5
5.8
41.9
39.8
mmol/mol
1.71
222
2267
214
2136
1.00
0.00
4.2
4.0
14.5
14.9
pmol/l
1.07
188
1914
11
106
1.04
0.00
5.5
4.9
—
—
—
0
0
290
2904
0.99
0.00
20.3
10.4
24.9
24.8
u/l
0.03
279
2786
256
2555
1.01
0.00
5.2
4.8
1.8
1.9
mu/l
0.76
226
2311
0
5
0.00
0.00
0.0
1.0
—
18.6
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
18.3
—
0
6
7
71
0.99
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
3.4
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
4.0
—
48.8
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
8
80
1.00
0.00
1.4
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_OTHER_BACT_INOTHER and mortality.

Females

Parameter HR [95% CI] p-value
AB1_OTHER_BACT_INOTHER 2.026 [1.66, 2.48] < 0.001
Birth year 0.995 [0.99, 1.0] 0.22

During the follow-up period (1.1.1998 — 31.12.2019), 562 out of 1325 females with AB1_OTHER_BACT_INOTHER died.

Males

Parameter HR [95% CI] p-value
AB1_OTHER_BACT_INOTHER 2.755 [2.11, 3.59] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 352 out of 852 males with AB1_OTHER_BACT_INOTHER died.

Mortality risk

Mortality risk for people of age

years, who have AB1_OTHER_BACT_INOTHER.

N-year risk Females Males
1 0.208% 0.509%
5 1.246% 2.961%
10 3.141% 7.155%
15 5.804% 13.554%
20 10.293% 21.955%

Relationships between endpoints

Index endpoint: AB1_OTHER_BACT_INOTHER – Other bacterial agents as the cause of diseases classified to other chapters

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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