Viral infections of central nervous system, not elsewhere classified/unspecified

AB1_VIRAN_CNS_INFECTIONS_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A88, A89
  • Hospital discharge: ICD-9 04[6|9]
  • Hospital discharge: ICD-8 04[6]
  • Cause of death: ICD-10 A88, A89
  • Cause of death: ICD-9 04[6|9]
  • Cause of death: ICD-8 04[6]

2 out of 7 registries used, show all original rules.

418

4. Check minimum number of events

None

418

5. Include endpoints

None

418

6. Filter based on genotype QC (FinnGen only)

418

Control definitions (FinnGen only)

Control exclude
AB1_VIRAL_CNS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3558 1691 1843
Only index persons 3046 1465 1581
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.05
Only index persons 0.06 0.05 0.06
Median age at first event (years)
Whole population 27.63 30.29 24.76
Only index persons 25.73 28.93 22.76

-FinnGen-

Key figures

All Female Male
Number of individuals 418 238 180
Unadjusted period prevalence (%) 0.08 0.08 0.08
Median age at first event (years) 28.90 30.24 27.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
384
Matched controls
3838
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
0499X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Unspecified non-arthropod-borne viral diseases of central nervous system
+∞
323.0
277
*
A89
ICD-10 Finland
Unspecified viral infection of central nervous system
+∞
42.5
40
*
0498X
ICD-9 Finland
Other non-arthropod-borne viral diseases of central nervous system, Other specified non-arthropod-borne viral diseases of central nervous system
+∞
37.1
35
*
A87.9
ICD-10 Finland
Viral meningitis, unspecified
+∞
15.7
15
*
04699
ICD-8 Finland
Other enterovirus diseases of central nervous system
+∞
12.6
12
*
A88.1
ICD-10 Finland
Epidemic vertigo
+∞
10.5
10
*
3229X
ICD-9 Finland
Meningitis of unspecified cause, Meningitis, unspecified
+∞
10.5
10
*
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
9.4
9
*
7840A
ICD-9 Finland
Symptoms involving head and neck, Headache
9.8
8.4
16
17
R51.80
ICD-10 Finland
Headache
2.5
8.0
67
302
TAB00
NOMESCO Finland
Lumbar puncture
4.4
7.8
27
65
AA1AD
NOMESCO Finland
CT of head and brain
2.2
7.3
85
448
J05AB11
ATC
valaciclovir; oral
2.3
6.4
58
274
A86
ICD-10 Finland
Unspecified viral encephalitis
+∞
6.3
6
*
N02AX02
ATC
tramadol; systemic, rectal
1.7
6.2
160
1114
R42
ICD-10 Finland
Dizziness and giddiness
2.0
6.2
79
432
R49.01
ICD-10 Finland
Functional dysphonia
5.3
6.1
17
33

Mortality – FinRegistry

Association

Association between endpoint AB1_VIRAN_CNS_INFECTIONS_NOS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_VIRAN_CNS_INFECTIONS_NOS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: AB1_VIRAN_CNS_INFECTIONS_NOS – Viral infections of central nervous system, not elsewhere classified/unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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