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Malignant neoplasm of eye and adnexa, excluding all cancers (controls excluding all cancers)

Endpoint Browser PheWeb

C3_EYE_ADNEXA_EXALLC

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C69
  • Hospital discharge: ICD-9 — 190
  • Hospital discharge: ICD-8 — 190
  • Cause of death: ICD-10 — C69
  • Cause of death: ICD-9 — 190
  • Cause of death: ICD-8 — 190
  • Cancer registry: Topography ICD-O-3 — C69
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

3 out of 7 registries used, show all original rules.

568

4. Check minimum number of events

None

568

5. Include endpoints

None

568

6. Filter based on genotype QC (FinnGen only)

568

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

↥

List of similar endpoints to Malignant neoplasm of eye and adnexa, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 568 260 308
Unadjusted period prevalence (%) 0.11 0.09 0.14
Median age at first event (years) 62.65 60.04 64.85

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
259
Matched controls
2588
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C69.30
ICD-10 Finland
Malignant tumor of the chorioidea without histology
+∞
155.3
133
*
CKE60
NOMESCO Finland
Brachytherapy of choroid and retina
+∞
137.0
119
*
CKE65
NOMESCO Finland
Removal of brachytherapeutic plate from eye
+∞
137.0
119
*
C69.32
ICD-10 Finland
Malignant tumor of the chorioidea melanoma
+∞
121.7
107
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
92.9
117.5
126
26
WX140
NOMESCO Finland
Parabulbar anesthesy
36.8
77.9
101
44
XCK10
NOMESCO Finland
Photography of fundus of eye
16.8
73.4
131
148
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
201.9
73.3
73
5
C69.3
ICD-10 Finland
Malignant neoplasm: Choroid
+∞
71.2
65
*
8720/3-C69.9
ICD-O-3
Malignant melanoma, NOS, of eye, NOS
+∞
70.0
64
*
8720/3-C69.3
ICD-O-3
Malignant melanoma, NOS, of choroid
+∞
67.7
62
*
130
Kela drug reimbursment
Malignant tumour
+∞
59.7
55
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
17.9
55.3
91
76
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
46.2
43
*
H02AB02
ATC
dexamethasone; systemic
55.6
39.4
46
10
WX002
NOMESCO Finland
Sedation and analgesia
7.0
38.9
117
273
C69.39
ICD-10 Finland
Malignant tumor in chorioidea other or unspecified histology
+∞
37.4
35
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
114.2
36.9
39
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
36.3
34
*
WF002
NOMESCO Finland
Radical radiotherapy
398.1
35.9
35
*
ZXD10
NOMESCO Finland
Scheduled procedure
5.4
35.9
168
655
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
8.8
34.9
82
129
A04AA02
ATC
granisetron; systemic, transdermal
366.7
32.6
32
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
31.9
30
*
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
+∞
31.9
30
*
Z3229
NOMESCO Finland
Other healthcare associate professional
7.6
31.0
80
143
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.0
30.8
86
172
A03FA01
ATC
metoclopramide; systemic, rectal
7.4
30.6
81
150
ZXA05
NOMESCO Finland
Left side
4.9
29.8
130
441
CFA20
NOMESCO Finland
Biopsy of conjunctiva
168.8
29.3
30
*
C69.02
ICD-10 Finland
Malignant tumor in conjunctival melanoma
+∞
28.7
27
*
9510/3-C69.2
ICD-O-3
Retinoblastoma, NOS, of retina
+∞
27.6
26
*
Z2221
NOMESCO Finland
Medical doctor
4.6
27.1
123
424
CAA30
NOMESCO Finland
Biopsy of orbit
+∞
26.5
25
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
50.0
26.2
31
7
JN4BD
NOMESCO Finland
Extensive body CT
10.3
25.9
53
63
Z51.5
ICD-10 Finland
Palliative care
16.0
25.1
41
30
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.8
24.5
55
77
C69.00
ICD-10 Finland
Malignant tumor of the conjunctiva without histology
+∞
24.3
23
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.8
23.4
91
260
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
23.3
22
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
23.3
22
*
ZXE00
NOMESCO Finland
One hour or less
3.7
22.1
147
674
CF2S4
NOMESCO Finland
Photography of conjunctiva
239.3
21.9
22
*
1906B
ICD-9 Finland
Malignant neoplasm of eye, Choroid[MELANOMA CHORIOIDEAE]
+∞
21.1
20
*
ZXA00
NOMESCO Finland
Right side
3.8
20.9
122
496
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.0
20.7
104
373
ZXE10
NOMESCO Finland
More than one and less than three hours
3.6
20.1
129
562
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
20.1
19
*
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
21.6
20.0
29
15
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
19.0
18
*
A04AA01
ATC
ondansetron; systemic, rectal
15.1
18.8
31
23
C61
ICD-10 Finland
Malignant neoplasm of prostate
204.1
18.8
19
*
S01ED51
ATC
timolol, combinations; ophthalmic
6.1
18.7
54
107
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
+∞
17.9
17
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
17.9
17
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
45.5
17.6
21
5
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
13.4
17.3
30
25
CFC00
NOMESCO Finland
Excision of lesion of conjunctiva
53.9
17.2
20
*
C69.21
ICD-10 Finland
Retina
+∞
16.8
16
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
16.8
16
*
L01AX03
ATC
temozolomide; systemic
+∞
16.8
16
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
181.1
16.7
17
*
N02AA05
ATC
oxycodone; systemic
4.6
16.5
63
170
XW000
NOMESCO Finland
Bone marrow biopsy
11.2
16.5
31
31
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
7.0
16.1
41
68
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
14.2
16.1
27
21
8000/3-C69.3
ICD-O-3
Neoplasm, malignant of choroid
+∞
15.8
15
*
9699/3-C69.6
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of orbit, NOS
+∞
15.8
15
*
C69.40
ICD-10 Finland
Malignant tumor of ciliary body without histology
+∞
15.8
15
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
15.8
15
*
3770
FHL
Placing a radiating plate on the surface of the eye with additional measures
+∞
15.8
15
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
15.8
15
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.0
15.7
141
740
JN4CD
NOMESCO Finland
Very extensive body CT
17.5
15.6
24
15
C69.42
ICD-10 Finland
Malignant tumor of ciliary melanoma
+∞
14.7
14
*
CDC10
NOMESCO Finland
Enucleation of eye with insertion of prosthesis
+∞
14.7
14
*
3779
FHL
Other operations in this group include disc removal
+∞
14.7
14
*
D31.6
ICD-10 Finland
Benign neoplasm: Orbit, unspecified
158.5
14.6
15
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
158.5
14.6
15
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
18.3
14.6
22
13
XX3DW
NOMESCO Finland
Time consuming IT work
7.2
14.3
35
55
CBA10
NOMESCO Finland
Biopsy of eyelid
45.2
14.3
17
*
115
Kela drug reimbursment
Breast cancer
+∞
13.7
13
*
180
Kela drug reimbursment
Interferon alfa
+∞
13.7
13
*
CDC00
NOMESCO Finland
Enucleation of eye
+∞
13.7
13
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
13.7
13
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
19.6
13.6
20
11
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
22.6
13.5
19
9
D31.0
ICD-10 Finland
Benign neoplasm: Conjunctiva
20.4
13.1
19
10
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
13.0
83
336
CD2S4
NOMESCO Finland
Photography of eye
73.5
12.7
14
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
12.6
12
*
C69.09
ICD-10 Finland
Malignant tumor in conjunctival other or unspecified histology
+∞
12.6
12
*
C69.20
ICD-10 Finland
Retina
+∞
12.6
12
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
12.6
12
*
PC2ET
NOMESCO Finland
Extensive embolisation of lesion of liver
+∞
12.6
12
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.6
12.3
126
683
Z3231
NOMESCO Finland
Registered nurse
2.8
11.7
95
446
JN6AD
NOMESCO Finland
CT of torso and neck
68.1
11.7
13
*
S01ED01
ATC
timolol; ophthalmic
7.2
11.6
28
43
C69.03
ICD-10 Finland
Malignant tumor of conjunctival carcinoma
+∞
11.5
11
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
11.5
11
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
11.5
11
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
11.5
11
*
C69.99
ICD-10 Finland
Malignant tumor in unspecified localization in eye or other unspecified histology
+∞
11.5
11
*
9699/3-C69.0
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of conjunctiva
+∞
11.5
11
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
8.7
11.4
24
30
CA1ME
NOMESCO Finland
Ultrasound oculometry
29.4
10.8
14
5
CH2S4
NOMESCO Finland
Photography of iris
+∞
10.5
10
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
+∞
10.5
10
*
116
Kela drug reimbursment
Prostate cancer
+∞
10.5
10
*
XX7GT
NOMESCO Finland
Selective internal radio therapy (SIRT) with Yttrium
+∞
10.5
10
*
C69.60
ICD-10 Finland
Malignant tumor in orbit without histology
+∞
10.5
10
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
10.5
10
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.6
10.4
36
87
WX142
NOMESCO Finland
Sub-tenon anesthesy
24.5
10.3
14
6
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
10.2
130
766
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
12.9
10.0
17
14
Z97.0
ICD-10 Finland
Presence of artificial eye
57.2
9.7
11
*
H26.2
ICD-10 Finland
Complicated cataract
10.6
9.7
18
18
A06AH03
ATC
naloxegol; oral
103.6
9.5
10
*
C82.1
ICD-10 Finland
Follicular lymphoma grade II
+∞
9.4
9
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
9.4
9
*
8720/3-C69.0
ICD-O-3
Malignant melanoma, NOS, of conjunctiva
+∞
9.4
9
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
9.4
9
*
C69.29
ICD-10 Finland
Retina
+∞
9.4
9
*
JN4AD
NOMESCO Finland
Body CT examination
6.5
9.2
23
38
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
19.5
9.0
13
7
WZC30
NOMESCO Finland
Teaching
3.7
8.9
39
118
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
51.8
8.7
10
*
L02AE02
ATC
leuprorelin; implant, parenteral
51.8
8.7
10
*
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
51.8
8.7
10
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
28.6
8.5
11
*
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
20.9
8.5
12
6
C69.2
ICD-10 Finland
Malignant neoplasm: Retina
+∞
8.4
8
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
8.4
8
*
L02BB03
ATC
bicalutamide; oral
+∞
8.4
8
*
1905A
ICD-9 Finland
Malignant neoplasm of eye, Retina[RETINOBLASTOMA RETINAE]
+∞
8.4
8
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
8.4
8
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
8.4
8
*
C69.63
ICD-10 Finland
Malignant tumor of orbital carcinoma
+∞
8.4
8
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
8.4
8
*
CAW99
NOMESCO Finland
Other operation on orbit
+∞
8.4
8
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
+∞
8.4
8
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
8.4
8
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
8.4
8
*
19003
ICD-8 Finland
Malignant neoplasm of eye, Retinae
+∞
8.4
8
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
8.4
8
*
ZXA10
NOMESCO Finland
Bilateral
2.6
8.1
68
316
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.4
7.9
23
46
H33.0
ICD-10 Finland
Retinal detachment with retinal break
7.4
7.9
18
26
H05.2
ICD-10 Finland
Exophthalmic conditions
46.4
7.8
9
*
ZX120
NOMESCO Finland
Intravenous
4.1
7.6
29
78
L03AB05
ATC
interferon alfa-2b; parenteral
82.3
7.5
8
*
HAB40
NOMESCO Finland
Wedge excision of mammary gland
82.3
7.5
8
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
82.3
7.5
8
*
9591/3-C69.9
ICD-O-3
Malignant lymphoma, non-Hodgkin, NOS, of eye, NOS
+∞
7.3
7
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
+∞
7.3
7
*
3102
FHL
Enucleation
+∞
7.3
7
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
7.3
7
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
7.3
7
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
7.3
7
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
7.3
7
*
CAD00
NOMESCO Finland
Exenteration of orbit with use of graft or flap
+∞
7.3
7
*
C69.45
ICD-10 Finland
Melanoma of iris
+∞
7.3
7
*
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
+∞
7.3
7
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
6.4
7.2
18
30
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
7.1
44
170
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
11.4
6.9
12
11
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.6
6.8
52
228
HA1AA
NOMESCO Finland
X-ray mammography
7.5
6.8
15
21
QAB10
NOMESCO Finland
Major dressing of wound of skin of head or neck
41.1
6.8
8
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
41.1
6.8
8
*
CA1AD
NOMESCO Finland
Orbita CT
41.1
6.8
8
*
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
6.2
6.7
17
29
D48.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other specified sites
23.2
6.7
9
*
ZX112
NOMESCO Finland
Subcutaneous
23.2
6.7
9
*
XCD20
NOMESCO Finland
Photoangiography of eye
7.2
6.6
15
22
H43.1
ICD-10 Finland
Vitreous haemorrhage
7.2
6.6
15
22
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
6.5
6.6
16
26
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
71.5
6.5
7
*
C83.1
ICD-10 Finland
Mantle cell lymphoma
+∞
6.3
6
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
6.3
6
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
6.3
6
*
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
6.3
6
*
PC2DT
NOMESCO Finland
Embolisation of lesion of liver
+∞
6.3
6
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
6.3
6
*
C69.91
ICD-10 Finland
Malignant tumor in unspecified localization in the eye retinoblastoma
+∞
6.3
6
*
A04AD12
ATC
aprepitant; systemic
+∞
6.3
6
*
L03AA02
ATC
filgrastim; parenteral
+∞
6.3
6
*
CFD10
NOMESCO Finland
Repair of conjunctiva
+∞
6.3
6
*
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
+∞
6.3
6
*
C69.90
ICD-10 Finland
Malignant tumor in unspecified localization in eye without histology
+∞
6.3
6
*
L02BG04
ATC
letrozole; oral
27.4
6.3
8
*
ZXE20
NOMESCO Finland
More than three and less than five hours
2.7
6.2
42
172
WW500
NOMESCO Finland
Blood transfusion
8.9
6.1
12
14

Mortality – FinRegistry

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This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

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Index endpoint: C3_EYE_ADNEXA_EXALLC – Malignant neoplasm of eye and adnexa, excluding all cancers (controls excluding all cancers)

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).