No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF9
- Parent code in ICD-10
- D01
- Name in latin
- Carcinoma in situ hepatis
Similar endpoints
↥List of similar endpoints to
Carcinoma in situ of rectum
based on the number of shared cases.
Similar with more cases:
- Carcinoma in situ of rectum
- Carcinoma in situ of other and unspecified digestive organs
- Carcinoma in situ of other and unspecified digestive organs
- In situ neoplasms
- In situ neoplasms
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 174 | 86 | 84 |
| Only index persons | 103 | 52 | 51 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 71.50 | 70.93 | 71.69 |
| Only index persons | 70.19 | 69.41 | 70.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 262 | 108 | 154 |
| Unadjusted period prevalence (%) | 0.06 | 0.04 | 0.07 |
| Median age at first event (years) | 70.09 | 69.02 | 70.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 233
- Matched controls
- 2328
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
89.8
136.0
148
44
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
62.7
131.7
157
74
8263/2-C20.9
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of rectum, NOS
+∞
105.4
93
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
70.5
64
*
C209, 8211, 2
ICD-O-3
NA
+∞
61.2
56
*
WX402
NOMESCO Finland
General anaesthesia
12.4
53.4
110
157
C209, 8148, 2
ICD-O-3
NA
+∞
53.2
49
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
49.8
46
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
39.7
49.4
62
21
UJF32
NOMESCO Finland
Coloscopy
8.1
46.4
141
370
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
43.1
40
*
130
Kela drug reimbursment
Malignant tumour
+∞
42.0
39
*
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
247.4
41.3
41
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
21.7
38.9
58
35
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
14.7
32.9
57
50
B01AB05
ATC
enoxaparin; parenteral
5.3
29.7
121
394
L01BC06
ATC
capecitabine; oral
+∞
28.7
27
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
27.7
26
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
27.7
26
*
JFF23
NOMESCO Finland
Transversostomy
151.9
26.2
27
*
JGA73
NOMESCO Finland
Transanal excision of lesion of rectum
145.6
25.1
26
*
JGB06
NOMESCO Finland
Partial proctectomy with total excision of mesorectum
+∞
23.3
22
*
TPH07
NOMESCO Finland
Cathetrisation of artery
8.0
23.2
56
89
UJG02
NOMESCO Finland
Proctoscopy
27.3
22.9
31
13
JN4AD
NOMESCO Finland
Body CT examination
14.9
22.1
37
29
C20.92
ICD-10 Finland
Malignant tumor of the rectum carcinoma of the adenoma
+∞
20.1
19
*
WF002
NOMESCO Finland
Radical radiotherapy
114.9
19.9
21
*
WX600
NOMESCO Finland
Single shot through catheter
114.9
19.9
21
*
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
76.4
19.0
21
*
JN4BD
NOMESCO Finland
Extensive body CT
9.1
17.7
38
49
H02AB02
ATC
dexamethasone; systemic
24.1
17.3
24
11
B01AB10
ATC
tinzaparin; parenteral
9.8
16.7
34
40
R4110
NOMESCO Finland
Physiotherapy
3.7
16.6
92
350
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
21.1
15.9
23
12
JG1CG
NOMESCO Finland
Extensive MRI of rectum
+∞
15.8
15
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
15.8
15
*
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
7.2
15.4
38
61
A04AA01
ATC
ondansetron; systemic, rectal
20.1
15.0
22
12
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
14.7
14
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
14.7
14
*
JGB03
NOMESCO Finland
Partial proctectomy with partial excision of mesorectum
+∞
14.7
14
*
JGA75
NOMESCO Finland
Endoscopic microsurgical excision of lesion of rectum
+∞
14.7
14
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.7
14.7
76
270
JG1BG
NOMESCO Finland
MRI of rectum
159.6
14.6
15
*
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
17.2
14.2
22
14
JGA85
NOMESCO Finland
Endoscopic mucosal or submucosal resection in rectum
57.0
14.0
16
*
8140/2-C20.9
ICD-O-3
Adenocarcinoma in situ, NOS, of rectum, NOS
+∞
13.7
13
*
JGB07
NOMESCO Finland
Laparoscopic partial proctectomy with total excision of mesorectum
+∞
13.7
13
*
A03FA01
ATC
metoclopramide; systemic, rectal
4.6
13.5
50
131
K62.1
ICD-10 Finland
Rectal polyp
18.7
12.7
19
11
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.1
12.6
84
356
D01.2
ICD-10 Finland
Carcinoma in situ: Rectum
+∞
12.6
12
*
JGB04
NOMESCO Finland
Laparoscopic partial proctectomy with partial excision of mesorectum
+∞
12.6
12
*
C209, 8213, 2
ICD-O-3
NA
+∞
12.6
12
*
JFG20
NOMESCO Finland
Closure of enterostomy with resection of exteriorised loop
137.1
12.6
13
*
XX3DW
NOMESCO Finland
Time consuming IT work
8.0
12.4
28
39
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
13.5
11.9
20
16
WZC30
NOMESCO Finland
Teaching
4.4
11.7
44
116
A04AA02
ATC
granisetron; systemic, transdermal
68.5
11.7
13
*
WF001
NOMESCO Finland
Preoperative radiotherapy
+∞
11.6
11
*
8140/3-C18.7
ICD-O-3
Adenocarcinoma, NOS, of sigmoid colon
+∞
11.6
11
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
11.6
11
*
TJF80
NOMESCO Finland
Ostomy education
63.0
10.7
12
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
115.0
10.5
11
*
116
Kela drug reimbursment
Prostate cancer
+∞
10.5
10
*
C18.71
ICD-10 Finland
Malignant tumor of the sigmoid invasive carcinoma
+∞
10.5
10
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
10.5
10
*
ZXC96
NOMESCO Finland
Robot assisted procedure
34.2
10.4
13
*
Z71.8
ICD-10 Finland
Other specified counselling
2.9
9.7
69
297
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
9.6
72
321
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
6.0
9.5
26
48
D75
ICPC
Malignant neoplasm colon/rectum
+∞
9.4
9
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
9.4
9
*
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
+∞
9.4
9
*
JFF11
NOMESCO Finland
Laparoscopic loop enterostomy
+∞
9.4
9
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
8.9
97
529
JFB31
NOMESCO Finland
Laparoscopic right hemicolectomy
93.3
8.5
9
*
TQW40
NOMESCO Finland
Remowal of suture of skin
4.4
8.5
30
75
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
8.4
8
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
8.4
8
*
C18.70
ICD-10 Finland
Malignant tumor of the sigmoid without histology
+∞
8.4
8
*
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
7.0
8.1
19
29
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
7.9
7.8
17
23
JGA05
NOMESCO Finland
Endoscopic polypectomy in rectum
26.0
7.6
10
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.5
7.6
35
111
N02BE01
ATC
paracetamol; systemic, rectal
2.9
7.5
206
1694
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
4.7
7.4
24
55
JGB10
NOMESCO Finland
Partial proctectomy and end colostomy
+∞
7.3
7
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
7.3
7
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
7.0
39
142
WX306
NOMESCO Finland
Lumbar epidural anesthesy
6.0
6.9
18
32
L02AE02
ATC
leuprorelin; implant, parenteral
23.3
6.7
9
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
12.7
6.6
11
9
QBE15
NOMESCO Finland
Excision of other superficial lesion of skin of trunk
71.7
6.5
7
*
JN4CD
NOMESCO Finland
Very extensive body CT
8.5
6.4
13
16
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
6.3
6
*
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
+∞
6.3
6
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
27.5
6.3
8
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.8
6.1
19
42
Mortality – FinRegistry
↥Association
Association between endpoint CD2_INSITU_RECTUM_EXALLC and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have CD2_INSITU_RECTUM_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: CD2_INSITU_RECTUM_EXALLC – Carcinoma in situ of rectum
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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