Carcinoma in situ of rectum

CD2_INSITU_RECTUM_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

  • not C3_RECTUM
-

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D01.2&
  • Hospital discharge: ICD-9 2304
  • Cause of death: ICD-10 D01.2&
  • Cause of death: ICD-9 2304
  • Cancer registry: Topography ICD-O-3 C20
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 2

3 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D01
Name in latin
Carcinoma in situ hepatis

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 174 86 84
Only index persons 103 52 51
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 71.50 70.93 71.69
Only index persons 70.19 69.41 70.98

-FinnGen-

Key figures

All Female Male
Number of individuals 262 108 154
Unadjusted period prevalence (%) 0.06 0.04 0.07
Median age at first event (years) 70.09 69.02 70.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
233
Matched controls
2328
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
89.8
136.0
148
44
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
62.7
131.7
157
74
8263/2-C20.9
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of rectum, NOS
+∞
105.4
93
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
70.5
64
*
C209, 8211, 2
ICD-O-3
NA
+∞
61.2
56
*
WX402
NOMESCO Finland
General anaesthesia
12.4
53.4
110
157
C209, 8148, 2
ICD-O-3
NA
+∞
53.2
49
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
49.8
46
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
39.7
49.4
62
21
UJF32
NOMESCO Finland
Coloscopy
8.1
46.4
141
370
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
43.1
40
*
130
Kela drug reimbursment
Malignant tumour
+∞
42.0
39
*
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
247.4
41.3
41
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
21.7
38.9
58
35
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
14.7
32.9
57
50
B01AB05
ATC
enoxaparin; parenteral
5.3
29.7
121
394
L01BC06
ATC
capecitabine; oral
+∞
28.7
27
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
27.7
26
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
27.7
26
*
JFF23
NOMESCO Finland
Transversostomy
151.9
26.2
27
*
JGA73
NOMESCO Finland
Transanal excision of lesion of rectum
145.6
25.1
26
*
JGB06
NOMESCO Finland
Partial proctectomy with total excision of mesorectum
+∞
23.3
22
*
TPH07
NOMESCO Finland
Cathetrisation of artery
8.0
23.2
56
89
UJG02
NOMESCO Finland
Proctoscopy
27.3
22.9
31
13
JN4AD
NOMESCO Finland
Body CT examination
14.9
22.1
37
29
C20.92
ICD-10 Finland
Malignant tumor of the rectum carcinoma of the adenoma
+∞
20.1
19
*
WF002
NOMESCO Finland
Radical radiotherapy
114.9
19.9
21
*
WX600
NOMESCO Finland
Single shot through catheter
114.9
19.9
21
*
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
76.4
19.0
21
*
JN4BD
NOMESCO Finland
Extensive body CT
9.1
17.7
38
49
H02AB02
ATC
dexamethasone; systemic
24.1
17.3
24
11
B01AB10
ATC
tinzaparin; parenteral
9.8
16.7
34
40
R4110
NOMESCO Finland
Physiotherapy
3.7
16.6
92
350
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
21.1
15.9
23
12
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
15.8
15
*
JG1CG
NOMESCO Finland
Extensive MRI of rectum
+∞
15.8
15
*
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
7.2
15.4
38
61
A04AA01
ATC
ondansetron; systemic, rectal
20.1
15.0
22
12
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
14.7
14
*
JGB03
NOMESCO Finland
Partial proctectomy with partial excision of mesorectum
+∞
14.7
14
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
14.7
14
*
JGA75
NOMESCO Finland
Endoscopic microsurgical excision of lesion of rectum
+∞
14.7
14
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.7
14.7
76
270
JG1BG
NOMESCO Finland
MRI of rectum
159.6
14.6
15
*
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
17.2
14.2
22
14
JGA85
NOMESCO Finland
Endoscopic mucosal or submucosal resection in rectum
57.0
14.0
16
*
JGB07
NOMESCO Finland
Laparoscopic partial proctectomy with total excision of mesorectum
+∞
13.7
13
*
8140/2-C20.9
ICD-O-3
Adenocarcinoma in situ, NOS, of rectum, NOS
+∞
13.7
13
*
A03FA01
ATC
metoclopramide; systemic, rectal
4.6
13.5
50
131
K62.1
ICD-10 Finland
Rectal polyp
18.7
12.7
19
11
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.1
12.6
84
356
D01.2
ICD-10 Finland
Carcinoma in situ: Rectum
+∞
12.6
12
*
C209, 8213, 2
ICD-O-3
NA
+∞
12.6
12
*
JGB04
NOMESCO Finland
Laparoscopic partial proctectomy with partial excision of mesorectum
+∞
12.6
12
*
JFG20
NOMESCO Finland
Closure of enterostomy with resection of exteriorised loop
137.1
12.6
13
*
XX3DW
NOMESCO Finland
Time consuming IT work
8.0
12.4
28
39
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
13.5
11.9
20
16
WZC30
NOMESCO Finland
Teaching
4.4
11.7
44
116
A04AA02
ATC
granisetron; systemic, transdermal
68.5
11.7
13
*
8140/3-C18.7
ICD-O-3
Adenocarcinoma, NOS, of sigmoid colon
+∞
11.6
11
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
11.6
11
*
WF001
NOMESCO Finland
Preoperative radiotherapy
+∞
11.6
11
*
TJF80
NOMESCO Finland
Ostomy education
63.0
10.7
12
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
115.0
10.5
11
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
10.5
10
*
116
Kela drug reimbursment
Prostate cancer
+∞
10.5
10
*
C18.71
ICD-10 Finland
Malignant tumor of the sigmoid invasive carcinoma
+∞
10.5
10
*
ZXC96
NOMESCO Finland
Robot assisted procedure
34.2
10.4
13
*
Z71.8
ICD-10 Finland
Other specified counselling
2.9
9.7
69
297
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
9.6
72
321
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
6.0
9.5
26
48
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
+∞
9.4
9
*
JFF11
NOMESCO Finland
Laparoscopic loop enterostomy
+∞
9.4
9
*
D75
ICPC
Malignant neoplasm colon/rectum
+∞
9.4
9
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
9.4
9
*
JFB31
NOMESCO Finland
Laparoscopic right hemicolectomy
93.3
8.5
9
*
TQW40
NOMESCO Finland
Remowal of suture of skin
4.4
8.5
30
75
C18.70
ICD-10 Finland
Malignant tumor of the sigmoid without histology
+∞
8.4
8
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
8.4
8
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
8.4
8
*
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
7.0
8.1
19
29
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
7.9
7.8
17
23
JGA05
NOMESCO Finland
Endoscopic polypectomy in rectum
26.0
7.6
10
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.5
7.6
35
111
N02BE01
ATC
paracetamol; systemic, rectal
2.9
7.5
206
1694
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
4.7
7.4
24
55
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
7.3
7
*
JGB10
NOMESCO Finland
Partial proctectomy and end colostomy
+∞
7.3
7
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
7.0
39
142
WX306
NOMESCO Finland
Lumbar epidural anesthesy
6.0
6.9
18
32
L02AE02
ATC
leuprorelin; implant, parenteral
23.3
6.7
9
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
12.7
6.6
11
9
QBE15
NOMESCO Finland
Excision of other superficial lesion of skin of trunk
71.7
6.5
7
*
JN4CD
NOMESCO Finland
Very extensive body CT
8.5
6.4
13
16
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
6.3
6
*
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
+∞
6.3
6
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
27.5
6.3
8
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.8
6.1
19
42

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
157
118
31.70
184.21
6.1
1.3
12.9
5.2
ug/l
0.54
130
91
185
204
28.45
175.22
2.3
1.3
—
—
—
0
0
216
875
9.36
53.72
5.5
3.5
—
—
—
0
0
57
59
12.07
51.12
1.6
1.2
—
—
—
0
0
79
144
7.42
44.55
1.3
1.1
—
—
—
0
0
164
585
5.82
44.40
3.6
2.1
—
—
—
0
0
98
227
6.30
43.32
1.8
2.3
5.6
7.7
umol/l
1.04
87
195
204
895
6.78
42.71
12.0
10.1
1.3
1.4
inr
1.09
59
239
203
906
6.51
41.05
7.7
3.4
34.5
35.7
g/l
2.22
198
842
162
632
5.10
37.65
2.7
1.6
—
—
—
0
0
81
182
5.99
36.41
1.9
2.0
34.4
31.6
u/l
0.36
69
153
128
448
4.63
33.37
3.7
2.0
—
—
—
0
0
204
1031
5.42
32.16
10.5
3.8
11.1
12.2
umol/l
1.15
199
968
139
624
3.61
23.50
3.8
2.9
21.1
162.5
e6/l
0.75
101
478
48
99
5.71
23.05
10.2
8.7
—
—
—
0
0
118
482
3.63
23.02
1.5
1.3
—
—
—
0
0
209
1250
4.32
22.09
7.3
4.1
6.7
6.8
mmol/l
0.34
200
1167
122
539
3.36
20.53
3.5
2.7
—
—
—
0
0
82
282
3.78
20.44
3.1
2.3
21.5
23.5
%
0.53
74
244
89
327
3.61
20.03
3.2
2.8
0.9
1.3
e6/l
0.70
44
166
124
572
3.22
19.12
3.7
2.8
0.2
0.5
e6/l
1.34
86
420
144
729
3.17
18.82
4.6
3.4
42.7
133.2
e6/l
1.38
103
513
121
555
3.19
18.76
6.6
3.8
—
—
—
0
0
175
1008
3.22
17.94
9.7
5.4
1.2
1.2
mmol/l
2.36
148
871
116
540
3.06
17.22
2.3
2.1
2.7
2.9
mg/l
0.76
101
461
163
923
3.03
16.82
8.1
5.0
1.2
1.2
mmol/l
1.92
152
818
126
650
2.81
15.00
7.1
5.2
—
—
—
0
0
91
396
2.99
14.88
3.5
2.5
525.0
569.3
mosm/kgh2o
1.29
81
325
114
567
2.79
14.45
4.5
3.4
7.4
7.4
ph
0.01
26
88
153
884
2.76
14.42
16.1
7.7
0.0
0.0
e9/l
0.48
121
727
15
14
11.30
13.87
1.2
1.2
—
—
—
0
0
159
955
2.69
13.58
6.7
5.2
23.8
27.0
%
3.02
153
878
155
935
2.61
12.88
6.8
5.0
2.7
3.1
%
1.06
150
857
175
1123
2.68
12.73
13.3
5.8
4.2
4.3
e9/l
0.17
145
982
155
942
2.58
12.57
6.9
5.2
9.0
8.7
%
0.59
150
867
195
1345
2.76
11.84
5.1
4.2
5107.8
711.3
e6/l
—
6
23
62
246
2.99
11.67
9.3
6.1
0.5
1.5
mmol/l
1.17
52
198
161
1026
2.48
11.36
6.5
4.9
1.7
1.8
e9/l
0.25
140
898
119
668
2.43
11.07
5.1
2.0
2.3
2.3
mmol/l
0.08
108
541
161
1040
2.42
10.81
6.9
4.9
0.2
0.2
e9/l
1.36
139
914
157
1004
2.41
10.78
6.5
4.8
0.6
0.6
e9/l
0.29
132
861
34
97
3.88
10.73
12.8
7.2
24.4
25.0
mmol/l
0.40
34
88
157
1011
2.38
10.51
6.5
4.8
0.0
0.0
e9/l
1.98
132
875
111
623
2.36
10.12
3.3
3.1
—
—
—
0
0
47
172
3.11
10.10
12.3
6.5
—
—
—
0
0
214
1607
2.81
9.93
4.5
4.1
16.0
12.6
mm/h
1.89
208
1455
61
262
2.73
9.80
3.0
2.2
1.9
1.7
%
0.94
56
234
84
424
2.44
9.66
3.0
2.2
4.3
4.9
e6/l
0.23
75
367
50
200
2.85
9.15
4.4
2.3
68.8
67.8
e9/l
0.07
30
160
252
2118
5.97
9.00
28.2
12.7
33.2
23.9
mg/l
3.97
241
1641
255
2252
5.95
8.69
34.5
15.7
139.5
139.8
mmol/l
0.87
255
2180
111
659
2.19
8.52
2.8
2.2
60.9
57.0
u/l
0.45
104
613
255
2257
5.86
8.51
35.2
15.8
4.0
4.0
mmol/l
1.63
255
2185
255
2260
5.80
8.33
35.2
15.3
89.4
81.8
umol/l
1.45
255
2260
58
263
2.55
8.26
7.0
4.8
1.0
1.0
mmol/l
0.39
53
238
255
2267
5.67
7.95
16.8
9.0
24.2
25.5
u/l
0.83
255
2169
146
992
2.07
7.60
4.0
3.6
0.0
0.0
estimate
0.00
38
157
201
1555
2.26
7.24
4.9
4.0
—
—
—
0
0
190
1442
2.16
7.12
5.4
4.1
—
—
—
0
0
14
27
5.42
7.05
4.2
2.1
35.3
33.9
pg
0.82
14
27
144
994
2.00
6.96
5.5
5.0
0.0
0.0
estimate
0.00
43
154
144
1011
1.94
6.45
4.0
3.7
0.0
0.0
estimate
0.00
39
151
61
314
2.23
6.44
2.6
1.9
—
—
—
0
0
45
206
2.43
6.20
1.4
1.9
217.7
148.4
ug/g
0.29
37
163
13
27
5.01
6.04
3.2
1.6
3.8
4.8
e9/l
0.65
13
27
13
28
4.83
5.80
4.2
2.3
51.7
57.5
%
0.45
13
28
87
531
1.96
5.77
4.4
3.3
—
—
—
0
0
35
147
2.59
5.76
5.6
3.2
—
—
—
0
0
71
411
2.00
5.44
4.9
2.1
2.5
2.4
mmol/l
1.00
66
349
255
2340
4.36
5.41
42.7
18.8
239.3
240.3
e9/l
0.09
250
2268
255
2341
4.34
5.41
42.7
18.8
91.8
91.4
fl
0.77
255
2291
116
793
1.83
5.34
3.0
3.5
—
—
—
0
0
255
2344
4.29
5.24
43.2
18.9
127.4
136.9
g/l
16.18
255
2293
255
2342
4.32
5.23
42.5
18.7
30.3
30.4
pg
0.70
255
2292
76
457
1.93
5.20
8.7
4.1
—
—
—
0
0
56
304
2.07
5.09
1.4
1.2
—
—
—
0
0
19
61
3.28
5.02
2.3
1.2
66.3
49.1
mg/l
0.42
13
51
19
61
3.28
5.02
2.3
1.2
59.6
35.5
mg/l
0.71
13
51
135
983
1.77
4.91
2.3
2.0
92.2
95.1
pmol/l
0.36
90
514
247
2200
3.14
4.87
25.9
12.4
—
—
—
0
0
14
38
3.84
4.71
3.3
1.6
17.1
16.1
%
—
9
18
31
139
2.40
4.46
1.7
1.3
—
—
—
0
0
10
22
4.69
4.34
1.6
1.1
698.8
2710.1
e6/l
—
5
15
29
128
2.42
4.31
4.7
4.1
0.1
0.0
%
—
8
29
30
135
2.38
4.28
4.5
4.0
0.0
0.0
%
—
9
32
14
41
3.55
4.25
1.6
1.1
—
—
—
0
0
191
1581
1.77
4.05
4.4
3.6
15.4
15.0
pmol/l
1.13
173
1415
88
593
1.73
4.02
3.3
2.4
3488.3
9856.6
umol/l
0.89
77
513
78
508
1.76
4.02
1.8
1.7
460.0
437.8
pmol/l
0.23
66
419
84
562
1.73
3.93
1.8
1.6
19.4
20.4
nmol/l
0.28
78
477
30
141
2.27
3.89
4.5
4.0
0.3
0.9
%
—
9
36
9
15
6.17
3.85
1.7
1.1
—
—
—
0
0
73
472
1.76
3.84
3.8
3.8
276.3
347.8
ng/l
0.13
63
395
19
72
2.77
3.82
3.9
1.7
—
—
—
0
0
7
8
8.95
3.79
1.0
1.0
—
—
—
0
0
215
1862
1.86
3.68
35.3
13.8
37.8
39.9
%
3.84
157
1226
64
403
1.78
3.67
1.2
1.3
2.5
1.6
u/ml
0.30
19
120
27
126
2.27
3.56
4.1
4.1
0.3
0.3
%
—
6
27
81
550
1.68
3.54
3.7
2.6
0.7
0.8
ug/l
0.26
57
377
64
407
1.76
3.54
4.7
4.0
—
—
—
0
0
12
36
3.45
3.52
5.4
2.1
—
—
—
0
0
0
86
0.00
3.38
0.0
9.4
—
—
—
0
0
8
14
5.86
3.36
1.5
1.1
—
—
—
0
0
25
116
2.28
3.35
2.1
2.4
—
—
—
0
0
222
1965
1.85
3.23
5.4
4.5
2.0
2.6
mu/l
0.49
204
1761
10
28
3.67
3.23
1.4
1.3
109.5
58.1
pmol/l
—
10
28
14
50
2.90
3.14
2.9
2.3
8.1
7.9
kpa
0.28
14
42
28
141
2.10
3.09
1.3
1.2
—
—
—
0
0
21
97
2.27
2.86
1.2
1.4
—
—
—
0
0
21
97
2.27
2.86
1.2
1.3
—
—
—
0
0
42
252
1.79
2.81
1.5
1.5
—
—
—
0
0
29
154
1.99
2.79
4.7
4.9
—
—
—
0
0
31
170
1.93
2.73
1.3
1.5
—
—
—
0
0
6
10
6.11
2.71
1.5
1.4
14.7
18.3
ug/l
—
6
10
9
25
3.69
2.60
4.2
1.8
3.3
150.7
u/ml
—
9
25
8
20
4.09
2.59
1.0
1.1
—
—
—
0
0
234
2140
1.87
2.58
4.9
5.0
5.9
6.0
mmol/l
0.90
220
1938
125
1004
1.47
2.43
5.5
4.0
2.0
2.1
ug/l
0.08
115
895
9
27
3.41
2.41
2.7
1.8
—
—
—
0
0
11
40
2.83
2.40
3.2
2.3
—
—
—
0
0
31
179
1.83
2.35
1.3
1.4
—
—
—
0
0
74
538
1.52
2.33
4.9
3.9
0.0
0.0
estimate
0.00
41
153
7
18
3.96
2.26
1.7
1.1
—
—
—
0
0
7
18
3.96
2.26
1.6
1.0
—
—
—
0
0
65
463
1.54
2.24
2.1
1.7
1079.9
1178.8
nmol/l
0.36
49
352
16
74
2.24
2.19
3.9
2.3
0.7
0.3
g/l
—
8
21
225
2057
1.66
2.19
6.8
6.5
40.0
40.4
mmol/mol
0.32
213
1899
8
26
3.14
2.03
3.1
1.4
1.5
1.7
mmol/l
—
8
26
9
32
2.88
2.02
3.9
2.5
—
—
—
0
0
9
33
2.79
1.95
1.1
1.2
—
—
—
0
0
20
108
1.92
1.87
6.0
3.8
23.2
24.4
mmol/l
0.68
20
96
52
367
1.52
1.86
1.4
1.2
2.8
2.9
g/l
0.04
29
216
17
87
2.02
1.84
1.0
1.3
—
—
—
0
0
7
23
3.10
1.81
3.0
1.3
87.6
90.4
%
—
7
23
38
252
1.59
1.78
2.4
1.7
—
—
—
0
0
5
13
3.90
1.72
1.0
1.2
—
—
—
0
0
33
214
1.62
1.70
1.4
1.5
—
—
—
0
0
7
25
2.85
1.66
3.3
5.3
9.2
7.4
mmol/l
—
7
19
89
711
1.38
1.65
3.6
3.2
—
—
—
0
0
33
217
1.60
1.61
6.5
3.4
0.6
1.9
mmol/l
0.72
27
176
234
2199
1.60
1.56
5.2
5.5
2.5
2.7
mmol/l
1.47
214
2009
61
461
1.42
1.55
4.5
1.7
2.5
1.1
mg/l
1.97
51
371
62
472
1.41
1.51
2.7
3.6
—
—
—
0
0
7
28
2.54
1.46
1.4
1.5
—
—
—
0
0
9
39
2.35
1.44
1.4
1.5
—
—
—
0
0
5
16
3.16
1.44
1.6
1.0
—
—
—
0
0
9
40
2.29
1.41
1.4
1.2
203.5
19.4
u/l
—
9
34
193
1762
1.36
1.39
38.0
16.9
329.5
332.6
g/l
4.39
193
1751
9
41
2.24
1.38
1.2
1.1
—
—
—
0
0
13
68
1.96
1.36
2.3
1.9
—
—
—
0
0
111
940
1.31
1.36
3.6
3.7
35.8
78.2
ng/l
0.61
87
685
33
229
1.50
1.30
6.6
3.5
—
—
—
0
0
6
25
2.43
1.25
1.7
1.2
—
—
—
0
0
6
25
2.43
1.25
1.0
1.1
—
—
—
0
0
11
58
1.94
1.14
5.4
2.6
24.8
24.7
mmol/l
0.02
11
47
10
51
2.00
1.12
7.8
2.2
33.7
33.5
umol/l
—
10
45
5
21
2.41
1.09
1.8
2.4
—
—
—
0
0
11
190
0.56
1.07
1.9
3.0
—
—
—
0
0
7
33
2.15
1.06
1.0
1.1
—
—
—
0
0
7
34
2.09
1.03
1.0
1.7
—
—
—
0
0
83
698
1.28
1.03
4.6
4.1
—
—
—
0
0
10
54
1.89
0.98
1.3
1.5
—
—
—
0
0
15
231
0.63
0.95
1.5
1.5
—
—
—
0
0
21
144
1.50
0.90
3.8
3.8
7.4
7.4
ph
—
6
11
17
111
1.57
0.90
4.2
3.8
—
—
—
0
0
225
2149
1.33
0.85
4.7
4.9
4.4
4.5
mmol/l
0.76
209
1969
6
32
1.90
0.82
2.0
1.3
—
—
—
0
0
21
148
1.46
0.81
4.0
3.7
5.1
5.0
kpa
0.05
21
138
83
722
1.22
0.75
2.1
2.1
101.8
315.0
u/l
1.34
78
672
5
24
2.10
0.75
1.2
1.1
—
—
—
0
0
5
26
1.94
0.71
1.6
1.8
—
—
—
0
0
11
69
1.62
0.69
1.5
1.6
—
—
—
0
0
91
805
1.20
0.69
4.2
3.9
29.3
6.8
mg/mmol
1.34
59
501
222
2133
1.27
0.67
4.6
4.9
1.4
1.4
mmol/l
0.23
205
1949
215
2060
1.24
0.65
4.1
4.4
1.3
1.3
mmol/l
0.12
199
1871
5
29
1.74
0.64
1.2
1.2
195.4
302.7
pmol/l
—
5
24
69
600
1.20
0.62
1.6
1.7
1.3
1.4
mmol/l
0.15
59
497
5
30
1.68
0.61
1.0
1.1
364.4
255.3
u/ml
—
5
16
16
114
1.43
0.60
3.2
1.3
2.1
1.2
g/l
0.55
16
105
10
66
1.54
0.53
5.5
4.3
—
—
—
0
0
39
332
1.21
0.45
1.3
1.3
27.3
12.0
u/ml
0.35
15
112
17
217
0.77
0.43
3.2
3.2
—
—
—
0
0
5
31
1.62
0.43
1.0
1.4
—
181.9
—
0
11
8
57
1.42
0.42
1.4
3.6
—
—
—
0
0
8
57
1.42
0.42
6.1
3.0
—
—
—
0
0
8
60
1.34
0.40
1.6
1.7
—
—
—
0
0
5
36
1.40
0.38
5.0
3.0
—
—
—
0
0
22
180
1.24
0.37
6.0
2.8
5.1
4.4
kpa
0.60
22
169
23
190
1.23
0.36
2.6
1.6
420.8
359.8
nmol/l
1.22
23
174
22
182
1.23
0.34
1.7
1.5
—
—
—
0
0
81
758
1.10
0.26
3.1
3.1
913.0
232.8
mg/l
0.45
50
471
20
170
1.19
0.25
1.1
1.4
—
—
—
0
0
6
83
0.72
0.24
1.2
1.1
—
—
—
0
0
83
781
1.09
0.24
3.1
3.0
7.3
7.7
mmol/l
0.42
68
646
5
41
1.22
0.22
1.2
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.9
—
—
—
0
0
0
10
0.00
0.21
0.0
13.4
—
950.4
—
0
10
0
10
0.00
0.21
0.0
16.0
—
1623.2
—
0
10
0
12
0.00
0.21
0.0
2.6
—
52.3
—
0
6
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
153.1
—
0
12
17
145
1.18
0.21
2.4
2.7
—
—
—
0
0
11
132
0.83
0.18
1.4
1.4
—
—
—
0
0
13
110
1.19
0.17
3.9
3.9
—
—
—
0
0
11
94
1.18
0.13
5.0
4.7
—
—
—
0
0
38
356
1.08
0.12
1.4
1.3
16.8
35.2
iu/ml
1.92
14
114
5
45
1.11
0.10
1.2
1.1
—
—
—
0
0
10
114
0.87
0.09
1.2
1.3
—
—
—
0
0
16
147
1.09
0.07
1.1
1.3
—
50.4
—
0
11
7
81
0.86
0.07
1.3
1.3
—
—
—
0
0
9
86
1.05
0.07
1.4
1.3
—
—
—
0
0
46
476
0.96
0.06
3.7
4.0
1.0
1.0
kg/l
—
6
70
12
113
1.06
0.02
1.4
1.2
90.2
117.1
iu/ml
—
7
38
11
117
0.94
0.02
5.8
2.5
1.1
1.2
%
0.14
11
117
14
133
1.06
0.01
1.1
1.2
—
—
—
0
0
17
166
1.03
0.00
2.1
2.5
—
17.4
—
0
6
0
7
0.00
0.00
0.0
5.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
5.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
2.6
—
0
9
6
64
0.94
0.00
1.0
1.2
—
—
—
0
0
6
61
0.98
0.00
1.2
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
5.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
10.4
—
0
5
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_INSITU_RECTUM_EXALLC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_RECTUM_EXALLC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: CD2_INSITU_RECTUM_EXALLC – Carcinoma in situ of rectum

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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