psoriatic arthritis: Joint inflammation associated with psoriasis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
368 |
4. Check minimum number of eventsNone |
368 |
5. Include endpointsNone |
368 |
6. Filter based on genotype QC (FinnGen only) |
368 |
Control definitions (FinnGen only)
- Control exclude
- PSOR_ENTE_ARTHR
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Arthropathy in Crohn disease
based on the number of shared cases.
Similar with more cases:
- Enteropathic arthropathies
- Psoriatic and enteropathic arthropathies
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1448 | 820 | 623 |
| Only index persons | 1391 | 801 | 590 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 45.47 | 45.71 | 45.14 |
| Only index persons | 45.12 | 45.60 | 44.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 368 | 232 | 136 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.06 |
| Median age at first event (years) | 43.90 | 43.23 | 45.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 337
- Matched controls
- 3371
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
323.0
276
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
182.7
268.3
265
66
K50.8
ICD-10 Finland
Other Crohn disease
331.7
225.2
207
16
K50.9
ICD-10 Finland
Crohn disease, unspecified
296.8
212.7
198
16
A07EC02
ATC
mesalazine; oral, rectal
67.8
185.4
215
85
L04AX01
ATC
azathioprine; systemic
82.0
182.8
202
60
K50.1
ICD-10 Finland
Crohn disease of large intestine
274.6
168.4
160
11
A07EC01
ATC
sulfasalazine; oral, rectal
50.8
166.8
207
102
K50.0
ICD-10 Finland
Crohn disease of small intestine
191.9
159.0
156
15
UJF32
NOMESCO Finland
Coloscopy
21.6
132.7
260
455
M07.4
ICD-10 Finland
Arthropathy in Crohn disease [regional enteritis]
+∞
132.2
118
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
31.3
126.8
178
116
A07EA06
ATC
budesonide; oral, local oral
50.6
125.0
151
53
H02AB06
ATC
prednisolone; systemic
13.9
90.0
288
1002
UJF30
NOMESCO Finland
Ileoscopy through colon
16.4
86.3
153
162
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
16.7
84.1
147
149
L04AB04
ATC
adalimumab; parenteral
63.2
83.7
96
21
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
109.4
78.2
83
10
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
41.9
66.7
83
26
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.3
60.8
200
560
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
+∞
60.2
56
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
25.6
59.1
84
43
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
11.8
48.7
96
110
L01BB02
ATC
mercaptopurine; oral
74.7
45.6
51
8
UJF92
NOMESCO Finland
Capsular endoscopy
31.5
45.2
60
23
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.6
43.7
167
503
ZX120
NOMESCO Finland
Intravenous
8.7
42.8
101
157
H02AB07
ATC
prednisone; oral
7.3
42.6
117
229
K51.5
ICD-10 Finland
Left sided colitis
22.3
41.5
61
33
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
10.4
41.3
86
107
J01MA02
ATC
ciprofloxacin; systemic
4.8
40.3
204
811
K50
ICD-10 Finland
Crohn disease [regional enteritis]
142.2
36.5
38
*
L40.5
ICD-10 Finland
Arthropathic psoriasis
142.2
36.5
38
*
M45
ICD-10 Finland
Ankylosing spondylitis
24.8
36.1
51
24
A07EA02
ATC
hydrocortisone; rectal
18.5
35.3
55
35
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
372.7
34.6
34
*
P01AB01
ATC
metronidazole; oral, rectal
4.2
34.1
212
968
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
19.2
33.2
51
31
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.1
32.2
193
837
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
59.1
32.0
37
7
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
121.5
31.3
33
*
N02AX02
ATC
tramadol; systemic, rectal
4.0
31.2
197
883
C10AC01
ATC
colestyramine; oral
21.1
31.1
46
25
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
18.4
30.9
48
30
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
36.4
28.4
36
11
M13.9
ICD-10 Finland
Arthritis, unspecified
8.2
28.1
66
97
M07.3
ICD-10 Finland
Other psoriatic arthropathies
+∞
27.5
26
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
7.7
27.0
66
103
L88
ICPC
Rheumatoid/seropositive arthritis
12.8
24.5
44
39
TPH04
NOMESCO Finland
Cathetrisation of vein
3.9
23.9
118
406
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
11.9
23.7
44
42
L04AC05
ATC
ustekinumab; parenteral
58.4
23.4
27
5
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
58.4
23.4
27
5
K51.8
ICD-10 Finland
Other ulcerative colitis
25.1
23.1
32
14
M074, L405
ICD-10 Finland
NA
+∞
22.1
21
*
M09.1*K50.9
ICD-10 Finland
Juvenile arthritis in Crohn's disease [regional enteritis]
+∞
22.1
21
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
19.1
21.8
33
19
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
12.8
21.3
38
33
4AA12
NOMESCO Finland
NA
82.1
20.9
23
*
JF1BD
NOMESCO Finland
Very extensive small bowel CT
61.4
20.2
23
*
4AB02
NOMESCO Finland
NA
78.0
19.9
22
*
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
33.6
19.5
25
8
A02BC02
ATC
pantoprazole; systemic
2.9
18.2
242
1572
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.6
18.2
95
330
WX002
NOMESCO Finland
Sedation and analgesia
3.5
18.0
96
340
L04AB06
ATC
golimumab; parenteral
70.5
17.9
20
*
56300
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Regional enteritis
+∞
17.9
17
*
D94
ICPC
Chronic enteritis/ulcerative colitis
25.7
17.6
24
10
JFB20
NOMESCO Finland
Ileocaecal resection
52.9
17.2
20
*
L04AA13
ATC
leflunomide; oral
15.1
17.1
28
20
5552A
ICD-9 Finland
Regional enteritis, Small intestine with large intestine
+∞
16.8
16
*
5551A
ICD-9 Finland
Regional enteritis, Large intestine
+∞
16.8
16
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
9.3
16.4
34
40
K60.3
ICD-10 Finland
Anal fistula
13.2
16.2
28
23
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.2
16.0
65
181
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
16.8
16.0
25
16
E0000UV
ATC
NA
2.6
15.8
166
907
JFB00
NOMESCO Finland
Partial resection of small intestine
27.8
15.8
21
8
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
20.5
15.8
23
12
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.6
15.7
160
858
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
11.2
15.5
29
28
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
18.9
15.4
23
13
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.4
15.2
84
302
D07AC01
ATC
betamethasone; topical
2.7
15.2
141
713
L40.0
ICD-10 Finland
Psoriasis vulgaris
7.3
15.0
36
54
P01BA02
ATC
hydroxychloroquine; oral
4.6
14.8
53
130
N02BE01
ATC
paracetamol; systemic, rectal
3.7
14.6
306
2445
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
15.3
14.3
23
16
A02BC01
ATC
omeprazole; systemic
2.7
14.0
117
551
B03BA03
ATC
hydroxocobalamin; parenteral
7.2
14.0
34
52
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
+∞
13.6
13
*
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
145.6
13.5
14
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.4
13.5
41
84
A02BC03
ATC
lansoprazole; oral
2.6
13.4
120
585
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.5
13.3
68
229
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
13.1
159
911
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.0
13.1
54
152
D05AX02
ATC
calcipotriol; topical
8.0
13.0
29
39
J01MA12
ATC
levofloxacin; systemic
3.1
12.8
81
315
A06AC01
ATC
ispaghula (psylla seeds); oral
2.8
12.7
98
433
M01AH01
ATC
celecoxib; oral (coxibs)
3.0
12.7
81
319
K56.7
ICD-10 Finland
Ileus, unspecified
18.2
12.7
19
11
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.1
12.5
50
137
WX302
NOMESCO Finland
Thoracal epidural anesthesy
5.8
12.3
35
66
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
39.1
12.3
15
*
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
14.3
11.6
19
14
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.3
11.5
61
210
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
+∞
11.5
11
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.8
11.4
49
143
E000001
ATC
NA
2.6
11.2
93
429
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.4
11.2
56
185
A02BC05
ATC
esomeprazole; systemic
2.2
11.0
154
918
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.7
11.0
49
147
B81
ICPC
Anaemia vit B12/folate deficiency
9.3
10.9
22
25
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.2
10.9
176
1122
D07XC01
ATC
betamethasone, combinations; topical
3.4
10.7
55
185
JX1LA
NOMESCO Finland
Kinetic X-ray of alimentary tract with pictures
62.0
10.7
12
*
A07DA03
ATC
loperamide; oral
6.8
10.5
26
41
JHD33
NOMESCO Finland
Completing incision of fistula-in-ano
113.4
10.5
11
*
5550A
ICD-9 Finland
Regional enteritis, Small intestine
+∞
10.5
10
*
M07.5
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
10.5
10
*
M25.5
ICD-10 Finland
Pain in joint
2.3
10.3
120
654
JHA00
NOMESCO Finland
Anal or perianal incision
11.8
10.2
18
16
M01AH05
ATC
etoricoxib; oral
2.1
10.0
218
1559
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
10.0
9.9
19
20
M54.9
ICD-10 Finland
Dorsalgia, unspecified
3.1
9.9
56
202
R50.9
ICD-10 Finland
Fever, unspecified
2.9
9.8
64
254
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.5
9.7
46
145
NH3EA
NOMESCO Finland
Feet X-ray examination with load
9.5
9.7
19
21
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.3
9.6
49
164
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
102.8
9.5
10
*
UJF02
NOMESCO Finland
Peroral enteroscopy
31.0
9.5
12
*
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
22.4
9.4
13
6
M075, K509
ICD-10 Finland
NA
+∞
9.4
9
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.3
9.4
49
167
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.5
9.3
32
76
H02AB09
ATC
hydrocortisone; systemic
8.7
9.2
19
23
L04AA01
ATC
[U] ciclosporin; systemic
11.9
9.2
16
14
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
5.5
9.1
26
50
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
12.0
8.7
15
13
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
16.8
8.6
13
8
A07EA01
ATC
prednisolone; rectal
28.3
8.5
11
*
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
28.3
8.5
11
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
8.5
50
185
A07EC03
ATC
olsalazine; oral
92.2
8.5
9
*
K61.0
ICD-10 Finland
Anal abscess
9.8
8.4
16
17
H04.10
ICD-10 Finland
Dry eye syndrome
3.1
8.3
46
161
NF1AA
NOMESCO Finland
Hip X-ray examination
4.0
8.3
33
90
J01DB01
ATC
cefalexin; oral
2.3
8.3
284
2352
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
8.2
102
561
107
Kela drug reimbursment
Pernicious anaemia
12.1
8.1
14
12
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
8.1
87
447
JHD30
NOMESCO Finland
Incomplete incision of fistula-in-ano
34.2
8.1
10
*
253
Kela drug reimbursment
NA
34.2
8.1
10
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
7.5
8.1
18
25
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.9
8.0
19
29
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.0
7.9
45
162
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
7.8
79
394
JFH10
NOMESCO Finland
Total colectomy and ileostomy
46.0
7.7
9
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
7.7
150
985
3042
Kela drug reimbursment
NA
25.7
7.6
10
*
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
7.4
7.6
17
24
A02BA02
ATC
ranitidine; systemic
2.4
7.5
69
330
M05BA04
ATC
alendronic acid; oral
4.0
7.5
29
78
JF1CM
NOMESCO Finland
Small bowel extensive MRI with with high intensity magnet
81.8
7.4
8
*
Z93.2
ICD-10 Finland
Ileostomy status
81.8
7.4
8
*
ZX140
NOMESCO Finland
Intra articular
13.8
7.4
12
9
L20
ICPC
Joint symptom/complaint NOS
4.7
7.4
24
54
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
7.4
70
337
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.3
7.4
37
123
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.2
7.4
38
129
L01BB01
ATC
NA
+∞
7.3
7
*
M074, K508
ICD-10 Finland
NA
+∞
7.3
7
*
JFA38
NOMESCO Finland
Endoscopic dilatation of small intestine
+∞
7.3
7
*
J01AA02
ATC
doxycycline; systemic
2.0
7.3
260
2106
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.9
7.2
172
1206
L12
ICPC
Hand/finger symptom/complaint
2.5
7.2
57
251
M01AH02
ATC
rofecoxib; oral
2.8
7.2
48
191
L52
ICD-10 Finland
Erythema nodosum
30.7
7.2
9
*
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
6.3
7.2
18
30
1370
FHL
Colonoscopy, whole colon
20.5
7.2
10
5
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
12.4
7.1
12
10
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
12.4
7.1
12
10
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
5.1
7.1
21
43
D07AC13
ATC
mometasone; topical
2.0
7.1
103
601
M01AH03
ATC
valdecoxib; oral
3.8
7.1
29
82
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
7.2
7.1
16
23
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
7.0
82
438
M01AX01
ATC
nabumetone; oral
4.6
7.0
23
53
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.9
7.0
130
831
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.9
7.0
27
73
R11
ICD-10 Finland
Nausea and vomiting
3.2
6.9
35
117
J01FA06
ATC
roxithromycin; oral
1.9
6.9
139
912
D07AB08
ATC
desonide; topical
2.7
6.9
47
191
H02AB04
ATC
methylprednisolone; systemic
2.5
6.9
56
252
D05AX52
ATC
calcipotriol, combinations; topical
4.1
6.8
25
64
J01FF01
ATC
clindamycin; systemic
2.0
6.8
101
593
B04AD01
ATC
NA
40.9
6.8
8
*
L04AD01
ATC
ciclosporin; systemic
6.7
6.7
16
25
J02AC01
ATC
fluconazole; systemic
1.8
6.7
149
1014
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
4.3
6.6
23
56
A02BX02
ATC
sucralfate; oral
4.7
6.6
21
47
D07AD01
ATC
clobetasol; topical
2.3
6.6
59
279
A05AA02
ATC
ursodeoxycholic acid; oral
7.6
6.5
14
19
JFH20
NOMESCO Finland
Proctocolectomy and ileostomy
71.1
6.4
7
*
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
14.7
6.4
10
7
M03BX02
ATC
tizanidine; oral
1.8
6.4
215
1662
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
6.4
52
232
JHD20
NOMESCO Finland
Incision of fistula-in-ano
9.5
6.3
12
13
L04AB05
ATC
certolizumab pegol; parenteral
18.4
6.3
9
5
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
5.2
6.3
18
36
L04AA17
ATC
[U] adalimumab; parenteral
+∞
6.3
6
*
6403
FHL
Ileocal resection
+∞
6.3
6
*
5559X
ICD-9 Finland
Regional enteritis, Unspecified site
+∞
6.3
6
*
M074K
ICD-10 Finland
NA
+∞
6.3
6
*
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
27.2
6.3
8
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.2
6.2
22
55
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.9
6.2
117
745
M01CB01
ATC
sodium aurothiomalate; parenteral
12.8
6.1
10
8
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.0
6.1
23
61
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.4
6.1
49
219
K60.0
ICD-10 Finland
Acute anal fissure
10.3
6.1
11
11
K83.0
ICD-10 Finland
Cholangitis
10.3
6.1
11
11
WW200
NOMESCO Finland
Immunization
4.9
6.0
18
38
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
288
428
27.35
222.13
8.6
2.1
176.4
94.8
ug/g
3.67
274
338
99
83
15.95
102.96
1.8
1.7
16.7
0.1
iu/ml
0.48
21
14
317
1109
14.41
100.76
11.2
4.6
36.7
36.7
g/l
0.05
312
1048
117
166
9.87
83.64
2.2
1.5
—
—
—
0
0
307
1197
10.44
81.50
4.6
2.2
72.2
75.3
nmol/l
1.28
302
1081
60
48
14.74
63.02
5.3
2.8
3.9
4.7
e9/l
1.10
60
48
60
49
14.44
62.25
5.4
3.3
57.7
57.1
%
0.10
60
49
338
1703
13.08
61.27
22.5
8.8
4.0
4.0
e9/l
0.06
328
1501
60
7
102.16
55.81
2.2
2.0
110.0
—
au/ml
—
6
0
194
644
5.26
55.72
4.7
2.0
2.8
2.8
mg/l
0.07
185
558
350
2189
13.24
40.33
23.6
6.9
74.2
75.9
u/l
0.60
345
2061
38
33
12.73
37.52
1.3
1.2
—
—
—
0
0
342
2202
8.83
34.97
12.1
3.6
12.9
10.0
mm/h
4.60
336
2039
108
352
3.93
28.96
2.3
2.3
20.4
25.1
%
2.57
97
305
207
1024
3.33
28.60
2.2
1.8
95.7
97.8
pmol/l
0.27
147
509
25
0
+∞
26.36
2.2
0.0
2.8
—
mg/l
—
25
0
249
1442
3.25
25.09
6.9
4.6
0.0
0.0
estimate
0.50
80
275
244
1399
3.21
24.98
4.7
2.7
90.6
102.3
ug/l
0.62
236
1304
249
1457
3.19
24.34
5.6
3.3
0.0
0.0
estimate
0.50
79
266
246
1431
3.17
24.27
5.5
3.2
0.0
0.0
estimate
0.00
74
273
245
1455
3.05
22.66
7.5
6.0
9.9
10.6
umol/l
0.65
232
1390
19
0
+∞
19.97
3.4
0.0
—
—
—
0
0
31
47
7.11
19.89
1.3
1.2
—
—
—
0
0
118
505
2.97
19.53
2.5
1.6
382.6
440.9
pmol/l
2.34
108
442
214
1251
2.70
19.20
6.6
6.6
1.2
1.2
mmol/l
0.24
174
1069
123
547
2.88
18.89
1.4
1.3
13.6
8.3
u/ml
0.30
48
222
150
752
2.68
18.13
6.5
3.5
0.0
0.0
estimate
0.80
80
273
165
877
2.60
17.58
5.3
2.5
59.4
53.8
u/l
1.91
156
821
172
946
2.54
16.88
4.1
2.8
—
—
—
0
0
180
1012
2.52
16.84
5.3
3.2
28.7
30.9
u/l
0.89
164
962
121
576
2.64
15.89
1.4
1.3
21.4
30.6
iu/ml
0.75
39
182
68
241
3.23
15.31
3.7
2.5
0.2
0.2
g/l
0.43
62
226
191
1138
2.41
15.31
6.0
5.7
1.2
1.2
mmol/l
0.54
170
1042
191
1141
2.40
15.18
6.1
3.2
—
—
—
0
0
24
40
6.35
14.04
1.9
2.2
0.7
1.3
%
0.51
16
31
136
740
2.33
12.92
3.8
2.6
0.3
0.4
e6/l
0.63
115
540
57
202
3.16
12.74
4.9
3.4
1.8
1.8
mmol/l
0.01
47
155
29
65
4.76
12.36
1.5
1.2
—
—
—
0
0
23
44
5.51
11.69
1.1
1.2
—
—
—
0
0
358
3078
7.00
11.25
36.6
11.3
12.6
20.4
mg/l
13.01
341
2373
87
410
2.47
11.23
2.0
1.6
1224.6
1237.2
nmol/l
0.04
66
306
127
712
2.20
10.90
2.1
2.4
4091.8
6075.4
umol/l
0.20
118
629
89
434
2.39
10.61
2.7
2.4
1.1
0.9
e6/l
0.49
61
233
36
111
3.49
10.01
2.2
2.0
—
—
—
0
0
226
1612
2.04
9.85
4.8
4.5
6.6
6.5
mmol/l
0.12
218
1472
62
268
2.58
9.51
3.0
2.4
33.7
29.7
u/l
0.59
53
219
335
2820
3.10
9.49
27.1
10.3
92.2
88.0
ml/min/173m2
3.32
310
2274
64
288
2.48
9.01
7.0
6.4
104.5
104.4
mmol/l
0.07
64
278
10
10
10.25
8.68
1.8
1.4
27.7
27.7
umol/l
—
10
10
153
984
1.95
8.64
3.3
3.0
19.5
36.8
ng/l
1.60
92
573
32
105
3.24
8.07
1.3
1.4
—
—
—
0
0
345
3026
3.24
7.60
22.1
12.4
139.1
139.7
mmol/l
5.12
338
2937
56
256
2.40
7.58
2.8
3.1
—
—
—
0
0
345
3033
3.20
7.43
22.1
12.5
3.9
4.0
mmol/l
3.34
338
2933
26
79
3.47
7.39
1.9
1.6
3.3
1.7
ug/l
0.24
26
73
28
92
3.21
7.05
1.3
1.2
—
—
—
0
0
28
92
3.21
7.05
1.3
1.2
—
—
—
0
0
17
39
4.52
7.03
1.6
1.3
—
—
—
0
0
97
577
1.92
6.63
1.8
1.4
18.2
21.5
nmol/l
1.65
87
496
53
252
2.29
6.54
16.2
17.0
1.1
1.3
inr
—
9
43
41
179
2.45
6.12
2.5
3.7
1.2
1.2
mmol/l
0.76
33
156
13
27
4.95
6.02
1.2
1.3
—
—
—
0
0
24
80
3.14
5.92
1.7
1.3
308.0
302.3
ug/g
0.05
13
41
41
185
2.37
5.70
8.5
7.9
8.6
8.8
mmol/l
0.07
41
180
130
883
1.73
5.63
3.2
3.0
2.3
2.3
mmol/l
0.73
120
789
72
409
1.95
5.57
2.7
2.5
2.5
2.7
e6/l
0.10
44
209
14
34
4.24
5.40
2.1
1.3
—
—
—
0
0
277
2328
1.77
5.23
4.1
4.0
14.8
14.5
pmol/l
0.99
251
2146
28
112
2.62
5.01
1.3
1.7
—
—
—
0
0
28
113
2.60
4.92
5.8
3.2
54.3
52.6
%
0.14
28
113
39
186
2.23
4.78
1.3
1.4
—
—
—
0
0
20
70
2.96
4.57
1.5
1.5
—
—
—
0
0
100
666
1.69
4.51
1.8
1.6
0.8
0.9
mg/l
0.43
82
505
19
65
3.03
4.51
1.3
1.6
—
—
—
0
0
63
367
1.86
4.49
2.2
1.8
—
—
—
0
0
314
2780
1.88
4.48
4.8
4.6
1.8
1.8
mu/l
0.18
293
2591
15
45
3.43
4.37
1.1
1.1
—
—
—
0
0
18
61
3.05
4.34
1.5
1.2
—
—
—
0
0
31
140
2.33
4.32
3.0
3.0
0.3
0.1
e6/l
0.79
31
134
17
56
3.13
4.30
1.5
1.2
409.7
200.1
u/ml
1.26
11
28
18
62
3.00
4.23
2.4
2.4
—
—
—
0
0
11
27
4.17
4.19
1.2
1.7
1.8
4.1
u/field
—
6
12
46
256
1.91
3.76
2.5
1.7
—
—
—
0
0
46
256
1.91
3.76
2.5
1.8
—
—
—
0
0
33
164
2.11
3.68
2.1
2.1
4970.2
2153.1
u/l
0.36
11
65
111
801
1.55
3.52
2.0
2.1
125.1
286.8
u/l
1.24
106
764
173
1373
1.49
3.49
5.4
4.0
—
—
—
0
0
8
14
5.81
3.36
1.4
2.1
—
—
—
0
0
30
152
2.06
3.20
2.6
3.5
90.6
87.0
ng/l
0.05
24
138
44
257
1.81
3.11
6.5
9.2
1.2
1.1
mmol/l
0.06
36
204
50
306
1.73
3.03
7.7
5.8
—
—
—
0
0
5
5
10.11
2.98
1.0
1.0
—
—
—
0
0
17
70
2.50
2.92
1.3
1.3
—
43.9
—
0
7
12
41
2.99
2.88
1.5
1.3
—
—
—
0
0
12
41
2.99
2.88
1.5
1.3
—
—
—
0
0
15
59
2.61
2.82
2.9
2.3
24.0
24.6
mmol/l
0.18
15
50
8
18
4.52
2.81
1.0
1.1
—
—
—
0
0
100
737
1.49
2.80
2.2
1.6
—
—
—
0
0
28
149
1.95
2.64
1.3
1.4
—
—
—
0
0
12
44
2.79
2.57
3.3
2.2
5.2
3.0
u/ml
0.66
12
39
8
21
3.87
2.47
1.5
1.2
—
—
—
0
0
9
27
3.39
2.41
1.8
1.6
—
—
—
0
0
99
749
1.44
2.40
1.2
1.3
1.0
1.4
u/ml
0.44
22
208
55
374
1.55
2.23
1.7
1.9
30.1
29.2
s
0.70
55
365
82
612
1.44
2.12
2.5
3.0
1083.8
758.3
ng/l
0.46
74
511
24
134
1.85
2.00
4.3
5.6
26.4
24.6
mmol/l
1.09
24
134
16
77
2.13
1.99
3.6
2.9
1.4
1.5
mg/l
0.28
16
72
24
135
1.83
1.96
2.9
2.9
1.2
1.7
mmol/l
0.20
19
98
62
450
1.45
1.86
2.0
2.0
1.6
1.4
%
0.45
52
406
6
17
3.57
1.84
2.0
2.2
—
—
—
0
0
9
35
2.61
1.81
1.3
1.3
—
—
—
0
0
18
95
1.94
1.78
1.8
1.7
—
—
—
0
0
14
68
2.10
1.72
1.1
1.2
—
—
—
0
0
23
374
0.59
1.69
1.7
1.6
—
—
—
0
0
11
49
2.28
1.65
1.4
1.3
—
—
—
0
0
32
207
1.60
1.63
1.2
1.2
36.5
276.2
u/ml
1.42
27
190
71
542
1.38
1.62
2.4
2.1
—
—
—
0
0
10
43
2.36
1.61
2.2
1.4
—
—
—
0
0
24
145
1.70
1.58
2.9
2.8
4.7
5.1
kpa
1.72
24
133
11
50
2.24
1.58
1.0
2.1
—
—
—
0
0
23
138
1.71
1.56
1.4
1.4
—
—
—
0
0
65
495
1.38
1.50
2.4
2.0
—
—
—
0
0
10
45
2.26
1.47
1.0
1.2
—
—
—
0
0
7
29
2.44
1.40
1.0
1.1
—
—
—
0
0
9
41
2.22
1.38
1.9
1.4
—
—
—
0
0
5
17
2.97
1.36
2.8
3.7
—
—
—
0
0
6
26
2.33
1.19
1.3
1.2
—
—
—
0
0
81
667
1.27
1.11
2.8
2.0
—
—
—
0
0
27
186
1.49
1.09
2.2
3.4
83.3
76.7
ng/l
0.11
22
171
8
41
1.97
1.09
2.0
1.4
—
—
—
0
0
8
41
1.97
1.09
1.9
1.4
—
—
—
0
0
7
35
2.02
1.00
1.0
1.1
—
—
—
0
0
5
23
2.19
0.98
3.0
1.3
0.8
1.1
g/l
—
5
23
5
23
2.19
0.98
4.0
3.5
—
—
—
0
0
11
62
1.80
0.95
1.5
1.4
—
—
—
0
0
31
227
1.40
0.94
5.0
2.3
77.8
72.8
ml/min/173m2
0.30
15
98
35
263
1.37
0.92
3.8
4.5
3.4
25.3
ug/l
0.72
24
210
11
63
1.77
0.91
1.5
1.4
—
—
—
0
0
307
2942
1.26
0.90
29.2
11.8
39.7
40.7
%
1.30
205
2332
7
127
0.54
0.90
1.0
1.4
—
—
—
0
0
7
127
0.54
0.90
1.0
1.4
—
—
—
0
0
7
127
0.54
0.90
1.0
1.4
—
—
—
0
0
7
127
0.54
0.90
1.0
1.4
—
—
—
0
0
6
29
2.09
0.89
1.3
1.1
—
—
—
0
0
8
42
1.92
0.89
1.4
1.4
—
—
—
0
0
247
2318
1.20
0.88
3.7
3.4
—
—
—
0
0
6
30
2.02
0.87
1.3
1.1
—
—
—
0
0
8
45
1.79
0.84
1.3
1.3
—
—
—
0
0
6
31
1.95
0.84
1.3
1.2
—
—
—
0
0
11
65
1.71
0.83
1.5
2.0
1.3
0.9
nmol/l
0.54
11
57
9
151
0.59
0.80
2.1
1.7
—
—
—
0
0
31
400
0.75
0.76
2.4
2.6
0.7
0.7
ug/l
0.07
16
215
12
75
1.62
0.75
6.7
3.5
3.8
3.9
mmol/l
0.20
12
67
19
133
1.45
0.75
1.5
1.3
230.0
269.2
miu/ml
0.20
12
69
45
551
0.79
0.74
4.5
3.6
19.7
21.7
%
0.42
20
219
9
55
1.65
0.74
2.1
1.2
—
—
—
0
0
13
84
1.57
0.73
1.4
1.8
—
—
—
0
0
299
2877
1.21
0.71
3.9
3.9
5.8
5.8
mmol/l
0.28
275
2678
5
26
1.94
0.71
1.0
1.0
—
—
—
0
0
30
233
1.31
0.67
2.0
1.7
—
—
—
0
0
13
86
1.53
0.67
1.1
2.2
—
—
—
0
0
13
86
1.53
0.67
1.1
2.2
6.8
7.3
g/l
—
6
72
13
86
1.53
0.67
1.1
2.2
3.3
3.7
g/l
—
6
63
5
28
1.80
0.66
2.0
2.9
3.7
2.9
nmol/l
—
5
28
17
120
1.44
0.66
2.4
1.4
—
—
—
0
0
24
311
0.76
0.62
3.5
3.9
33.2
31.9
%
0.20
19
212
13
88
1.49
0.61
1.8
1.9
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.6
—
—
—
0
0
13
89
1.48
0.58
1.0
1.3
—
—
—
0
0
280
2698
1.16
0.56
5.5
5.0
38.1
39.0
mmol/mol
0.95
267
2553
37
304
1.24
0.55
2.1
1.8
—
—
—
0
0
12
82
1.48
0.55
1.3
2.0
2.0
6.9
iu/l
—
7
31
6
38
1.59
0.54
1.2
1.3
—
—
—
0
0
56
483
1.19
0.53
4.2
3.6
22.4
457.2
ng/l
1.93
41
325
6
40
1.51
0.52
2.0
1.4
—
—
—
0
0
17
127
1.35
0.50
1.8
1.5
—
—
—
0
0
7
46
1.53
0.48
2.3
2.0
—
—
—
0
0
12
85
1.43
0.47
1.6
1.4
—
—
—
0
0
5
33
1.52
0.41
1.8
1.6
8.6
7.1
mmol/l
—
5
19
0
16
0.00
0.41
0.0
1.0
—
492.1
—
0
9
0
16
0.00
0.41
0.0
1.1
—
39.0
—
0
9
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
230
2211
1.11
0.40
4.6
3.1
58.0
42.9
u/l
1.53
220
2106
8
61
1.32
0.40
1.3
1.8
—
—
—
0
0
10
135
0.73
0.37
1.1
1.6
—
—
—
0
0
86
790
1.12
0.36
1.8
1.6
1.9
1.4
mmol/l
1.50
78
684
6
41
1.47
0.36
2.0
1.4
—
—
—
0
0
6
41
1.47
0.36
2.0
1.4
—
—
—
0
0
11
144
0.76
0.34
1.2
1.5
209.8
296.3
mu/l
1.56
11
128
14
175
0.79
0.31
1.1
1.0
—
—
—
0
0
57
624
0.90
0.28
1.8
1.5
—
—
—
0
0
14
112
1.26
0.28
1.5
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
3.5
—
—
—
0
0
0
13
0.00
0.21
0.0
3.5
—
—
—
0
0
10
123
0.81
0.20
1.5
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
13
154
0.84
0.19
1.8
1.4
—
—
—
0
0
297
3010
0.93
0.18
4.0
4.0
1.4
1.5
mmol/l
2.11
273
2826
8
73
1.10
0.16
1.1
1.2
—
—
—
0
0
303
3064
0.94
0.15
4.4
4.4
2.7
2.9
mmol/l
3.23
280
2875
77
741
1.05
0.11
4.2
4.0
16.7
10.7
mg/mmol
0.23
57
465
7
68
1.03
0.08
1.9
1.5
—
—
—
0
0
289
2908
0.97
0.06
3.7
3.6
1.5
1.3
mmol/l
4.16
266
2724
25
261
0.95
0.04
1.2
1.3
43.4
173.0
iu/ml
—
10
109
10
93
1.08
0.02
1.0
1.1
—
—
—
0
0
302
3018
1.00
0.00
4.1
4.0
4.6
4.8
mmol/l
1.92
282
2848
24
237
1.01
0.00
1.4
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
6
59
1.02
0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
105.1
—
0
9
8
85
0.94
0.00
1.5
1.8
237.9
240.2
pmol/l
—
8
80
6
61
0.98
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.2
—
0
5
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CROHN_ARTHR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CROHN_ARTHR | 1.408 [1.06, 1.87] | 0.018 |
| Birth year | 0.991 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 730 females with CROHN_ARTHR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CROHN_ARTHR | 1.394 [1.06, 1.83] | 0.018 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 562 males with CROHN_ARTHR died.
Mortality risk
Mortality risk for people of age
years, who have CROHN_ARTHR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.125% | 0.215% |
| 5 | 0.773% | 1.587% |
| 10 | 1.813% | 3.786% |
| 15 | 3.506% | 7.126% |
| 20 | 5.89% | 11.945% |
Relationships between endpoints
↥Index endpoint: CROHN_ARTHR – Arthropathy in Crohn disease
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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