Risteys · CROHN

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M07.4, M07.4K50.9 Cause of death: ICD-10 — M07.4, M07.4K50.9 2 out of 7 registries used, show all original rules.	368
4. Check minimum number of events None	368
5. Include endpoints None	368
6. Filter based on genotype QC (FinnGen only)	368

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1448	820	623
Only index persons	1391	801	590
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.03	0.03	0.02
Median age at first event (years)
Whole population	45.47	45.71	45.14
Only index persons	45.12	45.60	44.46

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	368	232	136
Unadjusted period prevalence (%)	0.07	0.08	0.06
Median age at first event (years)	43.90	43.23	45.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
337: Matched controls
3371

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M07.4*K50.9

ICD-10 Finland

Arthropathy in Crohn's disease [regional enteritis]

+∞

323.0

276

208

Kela drug reimbursment

Ulcerative colitis and Crohn's disease

182.7

268.3

265

K50.8

ICD-10 Finland

Other Crohn disease

331.7

225.2

207

K50.9

ICD-10 Finland

Crohn disease, unspecified

296.8

212.7

198

A07EC02

ATC

mesalazine; oral, rectal

67.8

185.4

215

L04AX01

ATC

azathioprine; systemic

82.0

182.8

202

K50.1

ICD-10 Finland

Crohn disease of large intestine

274.6

168.4

160

A07EC01

ATC

sulfasalazine; oral, rectal

50.8

166.8

207

102

K50.0

ICD-10 Finland

Crohn disease of small intestine

191.9

159.0

156

UJF32

NOMESCO Finland

Coloscopy

21.6

132.7

260

455

M07.4

ICD-10 Finland

Arthropathy in Crohn disease [regional enteritis]

+∞

132.2

118

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

31.3

126.8

178

116

A07EA06

ATC

budesonide; oral, local oral

50.6

125.0

151

H02AB06

ATC

prednisolone; systemic

13.9

90.0

288

1002

UJF30

NOMESCO Finland

Ileoscopy through colon

16.4

86.3

153

162

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

16.7

84.1

147

149

L04AB04

ATC

adalimumab; parenteral

63.2

83.7

326

Kela drug reimbursment

Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)

109.4

78.2

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

41.9

66.7

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

7.3

60.8

200

560

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

+∞

60.2

K51.9

ICD-10 Finland

Ulcerative colitis, unspecified

25.6

59.1

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

11.8

48.7

110

L01BB02

ATC

mercaptopurine; oral

74.7

45.6

UJF92

NOMESCO Finland

Capsular endoscopy

31.5

45.2

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

5.6

43.7

167

503

ZX120

NOMESCO Finland

Intravenous

8.7

42.8

101

157

H02AB07

ATC

prednisone; oral

7.3

42.6

117

229

K51.5

ICD-10 Finland

Left sided colitis

22.3

41.5

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

10.4

41.3

107

J01MA02

ATC

ciprofloxacin; systemic

4.8

40.3

204

811

K50

ICD-10 Finland

Crohn disease [regional enteritis]

142.2

36.5

L40.5

ICD-10 Finland

Arthropathic psoriasis

142.2

36.5

M45

ICD-10 Finland

Ankylosing spondylitis

24.8

36.1

A07EA02

ATC

hydrocortisone; rectal

18.5

35.3

M07.5*K51.9

ICD-10 Finland

Arthropathy in ulcerative colitis

372.7

34.6

P01AB01

ATC

metronidazole; oral, rectal

4.2

34.1

212

968

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

19.2

33.2

GD1AA

NOMESCO Finland

Thorax X-ray examination

4.1

32.2

193

837

K51.1

ICD-10 Finland

Ulcerative (chronic) ileocolitis

59.1

32.0

JF1DG

NOMESCO Finland

Small bowel very extensive MRI with with high intensity magnet

121.5

31.3

N02AX02

ATC

tramadol; systemic, rectal

4.0

31.2

197

883

C10AC01

ATC

colestyramine; oral

21.1

31.1

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

18.4

30.9

JF1CG

NOMESCO Finland

Extensive MRI of small bowel

36.4

28.4

M13.9

ICD-10 Finland

Arthritis, unspecified

8.2

28.1

M07.3

ICD-10 Finland

Other psoriatic arthropathies

+∞

27.5

UJF45

NOMESCO Finland

Flexible sigmoidoscopy with biopsy

7.7

27.0

103

L88

ICPC

Rheumatoid/seropositive arthritis

12.8

24.5

TPH04

NOMESCO Finland

Cathetrisation of vein

3.9

23.9

118

406

K52.9

ICD-10 Finland

Noninfective gastroenteritis and colitis, unspecified

11.9

23.7

L04AC05

ATC

ustekinumab; parenteral

58.4

23.4

O99.6

ICD-10 Finland

Diseases of the digestive system complicating pregnancy, childbirth and the puerperium

58.4

23.4

K51.8

ICD-10 Finland

Other ulcerative colitis

25.1

23.1

M074, L405

ICD-10 Finland

+∞

22.1

M09.1*K50.9

ICD-10 Finland

Juvenile arthritis in Crohn's disease [regional enteritis]

+∞

22.1

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

19.1

21.8

NA6BG

NOMESCO Finland

Sacro-iliac joint MRI examination with high intensity magnet

12.8

21.3

4AA12

NOMESCO Finland

82.1

20.9

JF1BD

NOMESCO Finland

Very extensive small bowel CT

61.4

20.2

4AB02

NOMESCO Finland

78.0

19.9

601

Kela drug reimbursment

Severe malabsorption of nutrients, mainly fats

33.6

19.5

A02BC02

ATC

pantoprazole; systemic

2.9

18.2

242

1572

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

3.6

18.2

330

WX002

NOMESCO Finland

Sedation and analgesia

3.5

18.0

340

L04AB06

ATC

golimumab; parenteral

70.5

17.9

56300

ICD-8 Finland

Chronic enteritis and ulcerative colitis, Regional enteritis

+∞

17.9

D94

ICPC

Chronic enteritis/ulcerative colitis

25.7

17.6

JFB20

NOMESCO Finland

Ileocaecal resection

52.9

17.2

L04AA13

ATC

leflunomide; oral

15.1

17.1

5552A

ICD-9 Finland

Regional enteritis, Small intestine with large intestine

+∞

16.8

5551A

ICD-9 Finland

Regional enteritis, Large intestine

+∞

16.8

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

9.3

16.4

K60.3

ICD-10 Finland

Anal fistula

13.2

16.2

JN3BD

NOMESCO Finland

Extensive abdominal CT

4.2

16.0

181

M46.1

ICD-10 Finland

Sacroiliitis, not elsewhere classified

16.8

16.0

E0000UV

ATC

2.6

15.8

166

907

JFB00

NOMESCO Finland

Partial resection of small intestine

27.8

15.8

M46.9

ICD-10 Finland

Inflammatory spondylopathy, unspecified

20.5

15.8

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.6

15.7

160

858

K51.3

ICD-10 Finland

Ulcerative (chronic) rectosigmoiditis

11.2

15.5

K51.0

ICD-10 Finland

Ulcerative (chronic) pancolitis

18.9

15.4

L30.9

ICD-10 Finland

Dermatitis, unspecified

3.4

15.2

302

D07AC01

ATC

betamethasone; topical

2.7

15.2

141

713

L40.0

ICD-10 Finland

Psoriasis vulgaris

7.3

15.0

P01BA02

ATC

hydroxychloroquine; oral

4.6

14.8

130

N02BE01

ATC

paracetamol; systemic, rectal

3.7

14.6

306

2445

K56.6

ICD-10 Finland

Other and unspecified intestinal obstruction

15.3

14.3

A02BC01

ATC

omeprazole; systemic

2.7

14.0

117

551

B03BA03

ATC

hydroxocobalamin; parenteral

7.2

14.0

5568X

ICD-9 Finland

Idiopathic proctocolitis, Other ulcerative colitis

+∞

13.6

UJF12

NOMESCO Finland

Enteroscopy through intestinal stoma

145.6

13.5

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

5.4

13.5

A02BC03

ATC

lansoprazole; oral

2.6

13.4

120

585

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.5

13.3

229

N02AJ06

ATC

codeine and paracetamol; systemic

2.4

13.1

159

911

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

4.0

13.1

152

D05AX02

ATC

calcipotriol; topical

8.0

13.0

J01MA12

ATC

levofloxacin; systemic

3.1

12.8

315

A06AC01

ATC

ispaghula (psylla seeds); oral

2.8

12.7

433

M01AH01

ATC

celecoxib; oral (coxibs)

3.0

12.7

319

K56.7

ICD-10 Finland

Ileus, unspecified

18.2

12.7

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

4.1

12.5

137

WX302

NOMESCO Finland

Thoracal epidural anesthesy

5.8

12.3

ZXE00

NOMESCO Finland

One hour or less

2.3

12.3

159

931

JH1CG

NOMESCO Finland

Extensive MRI of perianal area

39.1

12.3

M02.9

ICD-10 Finland

Reactive arthropathy, unspecified

14.3

11.6

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

3.3

11.5

210

JFB33

NOMESCO Finland

Other resection comprising small intestine and colon

+∞

11.5

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

3.8

11.4

143

E000001

ATC

2.6

11.2

429

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

3.4

11.2

185

A02BC05

ATC

esomeprazole; systemic

2.2

11.0

154

918

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

3.7

11.0

147

B81

ICPC

Anaemia vit B12/folate deficiency

9.3

10.9

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.2

10.9

176

1122

D07XC01

ATC

betamethasone, combinations; topical

3.4

10.7

185

JX1LA

NOMESCO Finland

Kinetic X-ray of alimentary tract with pictures

62.0

10.7

A07DA03

ATC

loperamide; oral

6.8

10.5

JHD33

NOMESCO Finland

Completing incision of fistula-in-ano

113.4

10.5

5550A

ICD-9 Finland

Regional enteritis, Small intestine

+∞

10.5

M07.5

ICD-10 Finland

Arthropathy in ulcerative colitis

+∞

10.5

M25.5

ICD-10 Finland

Pain in joint

2.3

10.3

120

654

JHA00

NOMESCO Finland

Anal or perianal incision

11.8

10.2

M01AH05

ATC

etoricoxib; oral

2.1

10.0

218

1559

JFA98

NOMESCO Finland

Other transluminal endoscopic local operation on intestine

10.0

9.9

M54.9

ICD-10 Finland

Dorsalgia, unspecified

3.1

9.9

202

R50.9

ICD-10 Finland

Fever, unspecified

2.9

9.8

254

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

3.5

9.7

145

NH3EA

NOMESCO Finland

Feet X-ray examination with load

9.5

9.7

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

3.3

9.6

164

56310

ICD-8 Finland

Chronic enteritis and ulcerative colitis, Ulcerative colitis

102.8

9.5

UJF02

NOMESCO Finland

Peroral enteroscopy

31.0

9.5

TNG11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in knee

22.4

9.4

M075, K509

ICD-10 Finland

+∞

9.4

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

3.3

9.4

167

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

4.5

9.3

H02AB09

ATC

hydrocortisone; systemic

8.7

9.2

L04AA01

ATC

[U] ciclosporin; systemic

11.9

9.2

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

5.5

9.1

ZY020

NOMESCO Finland

Telephone, letter or other consultation without direct patient contact

3.9

9.1

103

ZY010

NOMESCO Finland

Hospital outpatient

4.4

9.1

K56.5

ICD-10 Finland

Intestinal adhesions [bands] with obstruction

12.0

8.7

JF1AB

NOMESCO Finland

Passage examination of small bowell with X-ray

16.8

8.6

A07EA01

ATC

prednisolone; rectal

28.3

8.5

UJF14

NOMESCO Finland

Enteroscopy of ileoanal anastomosis

28.3

8.5

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

3.0

8.5

185

A07EC03

ATC

olsalazine; oral

92.2

8.5

K61.0

ICD-10 Finland

Anal abscess

9.8

8.4

H04.10

ICD-10 Finland

Dry eye syndrome

3.1

8.3

161

NF1AA

NOMESCO Finland

Hip X-ray examination

4.0

8.3

J01DB01

ATC

cefalexin; oral

2.3

8.3

284

2352

WX408

NOMESCO Finland

General anesthesy, balanced

2.2

8.2

102

561

107

Kela drug reimbursment

Pernicious anaemia

12.1

8.1

Z01.8

ICD-10 Finland

Other specified special examinations

2.3

8.1

447

JHD30

NOMESCO Finland

Incomplete incision of fistula-in-ano

34.2

8.1

253

Kela drug reimbursment

34.2

8.1

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

7.5

8.1

JJ2AT

NOMESCO Finland

Biopsy of liver with ultrasound guidance

6.9

8.0

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

3.0

7.9

162

A03FA01

ATC

metoclopramide; systemic, rectal

2.3

7.8

394

ZXD10

NOMESCO Finland

Scheduled procedure

2.0

7.8

137

866

JFH10

NOMESCO Finland

Total colectomy and ileostomy

46.0

7.7

ZXE10

NOMESCO Finland

More than one and less than three hours

2.0

7.7

127

781

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.9

7.7

150

985

3042

Kela drug reimbursment

25.7

7.6

TNX00

NOMESCO Finland

Puncture and needle biopsy of soft tissue, unspecified region

7.4

7.6

A02BA02

ATC

ranitidine; systemic

2.4

7.5

330

M05BA04

ATC

alendronic acid; oral

4.0

7.5

Z93.2

ICD-10 Finland

Ileostomy status

81.8

7.4

JF1CM

NOMESCO Finland

Small bowel extensive MRI with with high intensity magnet

81.8

7.4

ZX140

NOMESCO Finland

Intra articular

13.8

7.4

L20

ICPC

Joint symptom/complaint NOS

4.7

7.4

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.4

7.4

337

A49.9

ICD-10 Finland

Bacterial infection, unspecified

3.3

7.4

123

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

3.2

7.4

129

M074, K508

ICD-10 Finland

+∞

7.3

L01BB01

ATC

+∞

7.3

JFA38

NOMESCO Finland

Endoscopic dilatation of small intestine

+∞

7.3

J01AA02

ATC

doxycycline; systemic

2.0

7.3

260

2106

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.9

7.2

172

1206

L12

ICPC

Hand/finger symptom/complaint

2.5

7.2

251

M01AH02

ATC

rofecoxib; oral

2.8

7.2

191

L52

ICD-10 Finland

Erythema nodosum

30.7

7.2

ND2BA

NOMESCO Finland

Hand and fingers extensive X-ray examination

6.3

7.2

1370

FHL

Colonoscopy, whole colon

20.5

7.2

NH1AE

NOMESCO Finland

Ankle joint ultrasound examination

12.4

7.1

NG1AE

NOMESCO Finland

Knee joint ultrasound exmination

12.4

7.1

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

5.1

7.1

D07AC13

ATC

mometasone; topical

2.0

7.1

103

601

M01AH03

ATC

valdecoxib; oral

3.8

7.1

M06.0

ICD-10 Finland

Seronegative rheumatoid arthritis

7.2

7.1

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.2

7.0

438

M01AX01

ATC

nabumetone; oral

4.6

7.0

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.9

7.0

130

831

Z3231

NOMESCO Finland

Registered nurse

2.1

7.0

554

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

3.9

7.0

R11

ICD-10 Finland

Nausea and vomiting

3.2

6.9

117

J01FA06

ATC

roxithromycin; oral

1.9

6.9

139

912

D07AB08

ATC

desonide; topical

2.7

6.9

191

H02AB04

ATC

methylprednisolone; systemic

2.5

6.9

252

D05AX52

ATC

calcipotriol, combinations; topical

4.1

6.8

J01FF01

ATC

clindamycin; systemic

2.0

6.8

101

593

B04AD01

ATC

40.9

6.8

L04AD01

ATC

ciclosporin; systemic

6.7

J02AC01

ATC

fluconazole; systemic

1.8

6.7

149

1014

K43.9

ICD-10 Finland

Other and unspecified ventral hernia without obstruction or gangrene

4.3

6.6

A02BX02

ATC

sucralfate; oral

4.7

6.6

D07AD01

ATC

clobetasol; topical

2.3

6.6

279

A05AA02

ATC

ursodeoxycholic acid; oral

7.6

6.5

JFH20

NOMESCO Finland

Proctocolectomy and ileostomy

71.1

6.4

NA1EA

NOMESCO Finland

Cervical spine X-ray examination with flexion

14.7

6.4

M03BX02

ATC

tizanidine; oral

1.8

6.4

215

1662

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.5

6.4

232

JHD20

NOMESCO Finland

Incision of fistula-in-ano

9.5

6.3

L04AB05

ATC

certolizumab pegol; parenteral

18.4

6.3

NH3BA

NOMESCO Finland

Foot and toes extensive X-ray examination

5.2

6.3

5559X

ICD-9 Finland

Regional enteritis, Unspecified site

+∞

6.3

L04AA17

ATC

[U] adalimumab; parenteral

+∞

6.3

6403

FHL

Ileocal resection

+∞

6.3

M074K

ICD-10 Finland

+∞

6.3

NA6AA

NOMESCO Finland

Sacro-iliac joint X-ray examination

27.2

6.3

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

4.2

6.2

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.9

6.2

117

745

M01CB01

ATC

sodium aurothiomalate; parenteral

12.8

6.1

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

4.0

6.1

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

2.4

6.1

219

K83.0

ICD-10 Finland

Cholangitis

10.3

6.1

K60.0

ICD-10 Finland

Acute anal fissure

10.3

6.1

WW200

NOMESCO Finland

Immunization

4.9

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint CROHN_ARTHR and mortality.

Females

Parameter	HR [95% CI]	p-value
CROHN_ARTHR	1.408 [1.06, 1.87]	0.018
Birth year	0.991 [0.98, 1.0]	0.035

During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 730 females with CROHN_ARTHR died.

Males

Parameter	HR [95% CI]	p-value
CROHN_ARTHR	1.394 [1.06, 1.83]	0.018
Birth year	0.985 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 562 males with CROHN_ARTHR died.

Mortality risk

Mortality risk for people of age

years, who have CROHN_ARTHR.

N-year risk	Females	Males
1	0.125%	0.215%
5	0.773%	1.587%
10	1.813%	3.786%
15	3.506%	7.126%
20	5.89%	11.945%

Relationships between endpoints

↥

Index endpoint: CROHN_ARTHR – Arthropathy in Crohn disease

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	CROHN_ARTHR
CONTROL_EXCLUDE	PSOR_ENTE_ARTHR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M074
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M074
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Arthropathy in Crohn disease

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints