Arthropathy in Crohn disease

CROHN_ARTHR

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

382

4. Check minimum number of events

None

382

5. Include endpoints

None

382

6. Filter based on genotype QC (FinnGen only)

369

Control definitions (FinnGen only)

Control exclude
PSOR_ENTE_ARTHR

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1448 820 623
Only index persons 1391 801 590
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 45.47 45.71 45.14
Only index persons 45.12 45.60 44.46

-FinnGen-

Key figures

All Female Male
Number of individuals 369 231 138
Unadjusted period prevalence (%) 0.07 0.08 0.06
Median age at first event (years) 43.88 42.96 45.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
382
Matched controls
3820
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A07EC01
ATC
sulfasalazine; oral, rectal
45.0
316.2
229
123
L04AX01
ATC
azathioprine; systemic
92.2
307.7
229
61
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
307.7
328
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
214.1
307.7
234
28
K50.0
ICD-10 Finland
Crohn disease of small intestine
145.4
307.7
183
24
K50.8
ICD-10 Finland
Other Crohn disease
248.4
307.7
244
27
K50.1
ICD-10 Finland
Crohn disease of large intestine
216.4
307.7
182
16
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
176.5
307.7
308
88
A07EC02
ATC
mesalazine; oral, rectal
61.7
307.7
241
103
A07EA06
ATC
budesonide; oral, local oral
50.6
294.7
191
74
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
198.8
268.7
131
10
L04AX03
ATC
methotrexate; systemic
28.7
248.6
215
164
L04AB04
ATC
adalimumab; parenteral
73.8
224.9
125
25
UJF32
NOMESCO Finland
Coloscopy
22.1
199.0
296
515
UJF30
NOMESCO Finland
Ileoscopy through colon
18.7
180.1
185
183
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
13.9
137.5
163
194
L01BA01
ATC
methotrexate; systemic
34.3
132.3
88
33
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
25.5
130.3
98
51
M07.4
ICD-10 Finland
Arthropathy in Crohn disease [regional enteritis]
+∞
125.0
113
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
16.0
121.8
120
106
UJF92
NOMESCO Finland
Capsular endoscopy
35.5
117.9
77
27
L01BB02
ATC
mercaptopurine; oral
48.8
109.4
65
16
H02AB06
ATC
prednisolone; systemic
14.3
100.1
332
1209
ZX120
NOMESCO Finland
Intravenous
10.3
90.9
123
168
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
12.0
87.5
101
111
A07EA02
ATC
hydrocortisone; rectal
24.9
85.8
63
30
K51.5
ICD-10 Finland
Left sided colitis
18.7
84.2
71
46
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.2
83.3
232
676
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
20.4
77.3
62
36
M45
ICD-10 Finland
Ankylosing spondylitis
18.8
74.3
62
39
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
18.8
69.9
58
36
H02AB07
ATC
prednisone; oral
7.0
65.6
128
257
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.7
64.3
201
620
C10AC01
ATC
colestyramine; oral
16.2
63.5
57
41
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
20.0
57.6
46
26
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
222.5
56.7
57
*
K51.8
ICD-10 Finland
Other ulcerative colitis
20.6
56.0
44
24
J01MA02
ATC
ciprofloxacin; systemic
5.2
55.8
237
916
L88
ICPC
Rheumatoid/seropositive arthritis
12.4
51.5
54
50
M13.9
ICD-10 Finland
Arthritis, unspecified
7.6
50.1
80
128
K50
ICD-10 Finland
Crohn disease [regional enteritis]
146.6
49.1
51
*
P01AB01
ATC
metronidazole; oral, rectal
4.6
45.3
252
1140
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
7.3
45.2
74
121
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
10.0
44.2
54
62
L04AC05
ATC
ustekinumab; parenteral
247.8
43.9
44
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.6
43.7
147
458
N02AX02
ATC
tramadol; systemic, rectal
4.3
43.0
240
1076
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
454.4
42.0
41
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.2
41.7
233
1039
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
14.4
40.5
38
29
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
65.1
40.3
46
8
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
114.5
38.6
41
*
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
14.7
37.9
35
26
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
10.9
37.2
42
43
L40.5
ICD-10 Finland
Arthropathic psoriasis
108.3
36.5
39
*
K60.3
ICD-10 Finland
Anal fistula
13.7
35.4
34
27
256, ,
Kela drug reimbursment
368.3
34.5
34
*
L04AA13
ATC
[U] leflunomide
14.5
34.4
32
24
L40.0
ICD-10 Finland
Psoriasis vulgaris
9.0
32.2
42
52
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
11.9
31.5
33
30
WX002
NOMESCO Finland
Sedation and analgesia
3.8
29.1
112
372
D94
ICPC
Chronic enteritis/ulcerative colitis
39.5
28.9
36
10
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
42.6
28.6
35
9
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
27.9
28.1
38
15
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.7
26.8
71
178
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.7
26.6
69
170
JF1BD
NOMESCO Finland
Very extensive small bowel CT
75.2
25.2
28
*
H02AB09
ATC
hydrocortisone; systemic
10.7
25.0
28
28
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.0
24.8
199
1015
L04AB02
ATC
infliximab; parenteral
52.1
24.6
29
6
B03BA03
ATC
hydroxocobalamin; parenteral
7.0
24.4
39
61
M09.1*K50.9
ICD-10 Finland
Juvenile arthritis in Crohn's disease [regional enteritis]
+∞
24.2
23
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.3
24.2
120
464
M07.3
ICD-10 Finland
Other psoriatic arthropathies
255.3
23.9
24
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
23.8
80
239
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
30.5
23.6
31
11
A02BC02
ATC
pantoprazole; systemic
3.4
23.0
294
1906
M01AH01
ATC
celecoxib; oral
3.5
22.7
97
340
M074, L405,
ICD-10 Finland
+∞
22.1
21
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
6.0
22.0
41
75
4AA12, ,
NOMESCO Finland
85.2
21.9
24
*
4AB02, ,
NOMESCO Finland
85.2
21.9
24
*
D05AX02
ATC
calcipotriol; topical
8.1
21.5
30
40
D07AC01
ATC
betamethasone; topical
2.8
21.4
178
907
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
23.1
19.8
28
13
WVA20
NOMESCO Finland
Medicine administration
7.7
19.3
28
39
J01MA12
ATC
levofloxacin; systemic
3.2
19.3
95
361
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.2
19.0
56
151
5551A
ICD-9 Finland
Regional enteritis, Large intestine
+∞
18.9
18
*
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
22.2
18.9
27
13
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.8
18.6
65
198
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
15.4
18.4
30
21
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.8
18.3
44
101
JFB20
NOMESCO Finland
Ileocaecal resection
34.8
18.2
23
7
L04AB06
ATC
golimumab; parenteral
28.3
18.0
24
9
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
18.0
209
1226
A06AC01
ATC
ispaghula (psylla seeds); oral
2.8
17.9
125
572
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.7
17.8
62
188
56300
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Regional enteritis
+∞
17.8
17
*
A07DA03
ATC
loperamide; oral
7.2
17.6
27
40
P01BA02
ATC
hydroxychloroquine; oral
3.9
17.4
56
161
3042, ,
Kela drug reimbursment
66.4
16.9
19
*
253, ,
Kela drug reimbursment
66.4
16.9
19
*
E0000UV, ,
ATC
2.5
16.9
195
1131
A02BC01
ATC
omeprazole; systemic
2.6
16.6
131
634
JFB00
NOMESCO Finland
Partial resection of small intestine
17.7
16.3
25
15
A02BC03
ATC
lansoprazole; oral
2.6
16.2
134
663
L04AA33
ATC
[U] vedolizumab
62.8
15.9
18
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
15.8
108
485
JHA00
NOMESCO Finland
Anal or perianal incision
14.6
15.7
26
19
R50.9
ICD-10 Finland
Fever, unspecified
3.0
15.6
81
314
5552A
ICD-9 Finland
Regional enteritis, Small intestine with large intestine
166.5
15.6
16
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.0
15.4
79
304
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
47.0
15.2
18
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
5.2
15.0
32
66
M25.5
ICD-10 Finland
Pain in joint
2.4
14.7
164
921
K56.7
ICD-10 Finland
Ileus, unspecified
16.2
14.6
23
15
M05BA04
ATC
alendronic acid; oral
4.5
14.5
37
89
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.5
14.5
54
171
A02BC05
ATC
esomeprazole; systemic
2.3
14.4
181
1068
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.6
14.2
104
481
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
31.4
14.0
18
6
ZY010
NOMESCO Finland
Hospital outpatient
4.1
13.9
41
110
JHD33
NOMESCO Finland
Completing incision of fistula-in-ano
78.0
13.7
15
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
13.6
63
228
D07XC01
ATC
betamethasone; topical
3.1
13.5
62
223
WZC00
NOMESCO Finland
Treatment plan or consultation
2.3
13.4
159
910
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.1
13.3
61
219
B81
ICPC
Anaemia vit B12/folate deficiency
6.2
13.2
23
39
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.2
13.2
56
192
D05AX52
ATC
calcipotriol, combinations; topical
4.7
13.1
31
70
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
19.9
13.0
19
10
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.3
12.9
34
84
ZXE00
NOMESCO Finland
One hour or less
2.2
12.8
169
1006
N02BE01
ATC
paracetamol; systemic, rectal
4.4
12.7
359
2975
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.2
12.7
199
1267
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.8
12.6
40
113
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.7
12.6
42
123
L04AA01
ATC
[U] ciclosporin
20.9
12.6
18
9
M07.5
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
12.6
12
*
E000001, ,
ATC
2.5
12.5
99
472
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
13.0
12.3
21
17
H04.10
ICD-10 Finland
Dry eye syndrome
2.9
12.2
63
242
UJF02
NOMESCO Finland
Peroral enteroscopy
27.7
12.1
16
6
WX402
NOMESCO Finland
General anaesthesia
2.4
12.0
100
487
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
48.3
12.0
14
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.0
11.9
56
204
J01FF01
ATC
clindamycin; systemic
2.3
11.8
122
653
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
11.6
11.7
21
19
NH3EA
NOMESCO Finland
Feet X-ray examination with load
12.3
11.5
20
17
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
11.3
93
449
JX1LA
NOMESCO Finland
Kinetic X-ray of alimentary tract with pictures
36.2
11.3
14
*
A07AA09
ATC
vancomycin; oral
17.7
11.3
17
10
L20
ICPC
Joint symptom/complaint NOS
4.4
11.3
29
70
A02BA02
ATC
ranitidine; systemic
2.6
11.2
77
342
A02BX02
ATC
sucralfate; oral
6.0
11.1
20
35
WW200
NOMESCO Finland
Immunization
6.0
11.1
20
35
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.1
11.0
146
859
K61.0
ICD-10 Finland
Anal abscess
9.3
10.9
22
25
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.1
10.9
49
174
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.6
10.8
68
289
JHD30
NOMESCO Finland
Incomplete incision of fistula-in-ano
29.0
10.8
14
5
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
61.8
10.7
12
*
JFH20
NOMESCO Finland
Proctocolectomy and ileostomy
+∞
10.5
10
*
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
10.0
10.4
20
21
M01AH05
ATC
etoricoxib; oral
2.1
10.3
263
1953
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
10.2
111
601
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
10.1
97
499
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
17.3
9.9
15
9
WZC30
NOMESCO Finland
Teaching
2.5
9.9
73
334
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.7
9.9
23
51
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
20.7
9.9
14
7
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
9.8
46
167
TQW80
NOMESCO Finland
Local dermatologic skincare
5.5
9.7
19
36
H02AB04
ATC
methylprednisolone; systemic
2.6
9.7
63
272
L04AD01
ATC
ciclosporin; systemic
9.5
9.6
19
21
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.1
9.6
42
146
M01AH03
ATC
valdecoxib; oral
3.8
9.6
30
84
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.7
9.6
55
223
D07AD01
ATC
clobetasol; topical
2.4
9.5
75
354
R03AC02
ATC
salbutamol; inhalant
2.0
9.5
234
1692
M01AH02
ATC
rofecoxib; oral
2.7
9.5
55
224
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
9.5
150
932
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
5.4
9.5
19
37
5550A
ICD-9 Finland
Regional enteritis, Small intestine
102.5
9.5
10
*
JF1CM
NOMESCO Finland
Small bowel extensive MRI with with high intensity magnet
102.5
9.5
10
*
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
102.5
9.5
10
*
M075, K509,
ICD-10 Finland
+∞
9.4
9
*
M074, K508,
ICD-10 Finland
+∞
9.4
9
*
J02AC01
ATC
fluconazole; systemic
2.0
9.4
174
1141
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
7.6
9.3
21
29
N03AX12
ATC
[U] gabapentin; oral
2.3
9.3
77
371
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
9.3
146
904
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
8.6
9.2
19
23
NF1AA
NOMESCO Finland
Hip X-ray examination
3.3
9.2
35
112
J01DB01
ATC
cefalexin; oral
2.6
9.0
333
2774
A07EA01
ATC
prednisolone; oral, rectal
24.7
9.0
12
5
L04AB05
ATC
certolizumab pegol; parenteral
24.7
9.0
12
5
Z3231
NOMESCO Finland
Registered nurse
2.1
8.9
114
653
D07AC13
ATC
mometasone; topical
2.0
8.9
119
693
M01AX01
ATC
nabumetone; oral
4.1
8.7
24
61
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.8
8.7
27
75
R11
ICD-10 Finland
Nausea and vomiting
2.8
8.7
47
184
S18
ICPC
Laceration/cut
1.9
8.7
171
1136
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
3.6
8.7
29
85
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.2
8.6
23
57
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.7
8.6
21
33
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
8.6
176
1184
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.8
8.5
44
168
ZX140
NOMESCO Finland
Intra articular
20.6
8.5
12
6
JFA58
NOMESCO Finland
Endoscopic dilatation of colon
92.0
8.4
9
*
JFA38
NOMESCO Finland
Endoscopic dilatation of small intestine
92.0
8.4
9
*
JFH10
NOMESCO Finland
Total colectomy and ileostomy
92.0
8.4
9
*
A03FA02
ATC
cisapride; oral, rectal
3.3
8.4
32
102
M54.5
ICD-10 Finland
Low back pain
1.9
8.4
151
971
JFB21
NOMESCO Finland
Laparoscopic ileocaecal resection
+∞
8.4
8
*
5559X
ICD-9 Finland
Regional enteritis, Unspecified site
+∞
8.4
8
*
B01AB05
ATC
enoxaparin; parenteral
2.0
8.3
116
684
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
14.9
8.3
13
9
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.6
8.3
27
78
1370
FHL
Colonoscopy, whole colon
22.6
8.1
11
5
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
4.8
8.0
18
39
SPAT1263
SPAT
Sampling
1.9
7.9
163
1091
J01FA06
ATC
roxithromycin; oral
1.9
7.9
159
1056
WZA10
NOMESCO Finland
Extensive medical or dental certificate
8.3
7.7
16
20
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.6
7.7
26
77
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
12.2
7.6
13
11
L04AG05
ATC
vedolizumab; parenteral
25.6
7.6
10
*
Z93.2
ICD-10 Finland
Ileostomy status
25.6
7.6
10
*
UJD02
NOMESCO Finland
Gastroscopy
3.7
7.5
24
68
N03AX16
ATC
[U] pregabalin
2.0
7.5
93
524
N06AX11
ATC
mirtazapine; oral
1.9
7.4
138
889
A07EC03
ATC
olsalazine; oral
81.6
7.4
8
*
S01BA01
ATC
dexamethasone; ophthalmic
4.2
7.4
20
50
SPAT1310
SPAT
Counselling related to known health issue
1.9
7.4
127
799
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
7.4
49
213
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
11.2
7.3
13
12
JAH00
NOMESCO Finland
Laparotomy
6.0
7.3
19
33
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.0
7.3
33
117
M07.0*L40.5
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
+∞
7.3
7
*
4AA33, ,
NOMESCO Finland
+∞
7.3
7
*
L52
ICD-10 Finland
Erythema nodosum
16.1
7.3
11
7
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.7
7.3
23
65
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.5
7.2
25
75
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
6.8
7.2
17
26
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
30.6
7.2
9
*
J01AA02
ATC
doxycycline; systemic
2.0
7.2
294
2404
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
7.1
88
494
M03BX02
ATC
tizanidine; oral
1.8
7.1
254
1985
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.3
7.1
60
291
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
6.5
7.0
17
27
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.3
7.0
26
82
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
14.1
6.9
11
8
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.0
6.9
30
104
D07AB08
ATC
desonide; topical
2.3
6.9
53
246
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.9
6.9
20
53
D64.9
ICD-10 Finland
Anaemia, unspecified
2.7
6.8
37
145
JHD20
NOMESCO Finland
Incision of fistula-in-ano
9.6
6.8
13
14
K91.2
ICD-10 Finland
Postsurgical malabsorption, not elsewhere classified
40.8
6.8
8
*
JF1AD
NOMESCO Finland
Small bowel CT
17.1
6.8
10
6
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
17.1
6.8
10
6
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.8
6.8
148
997
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
23.0
6.7
9
*
A03CA02
ATC
clidinium and psycholeptics; oral
3.7
6.7
21
59
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
6.7
100
599
D02AE01
ATC
carbamide; topical
2.9
6.6
32
118
C05AA08
ATC
fluocortolone; rectal, topical
2.3
6.6
51
237
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.8
6.6
20
55
107
Kela drug reimbursment
Pernicious anaemia
7.6
6.5
14
19
K83.0
ICD-10 Finland
Cholangitis
7.6
6.5
14
19
L01BB01, ,
ATC
71.0
6.4
7
*
L04AF03
ATC
upadacitinib; oral
71.0
6.4
7
*
M01CB01
ATC
sodium aurothiomalate; parenteral
14.6
6.4
10
7
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.3
6.4
24
76
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
6.4
77
428
Z2446
NOMESCO Finland
Social worker
2.7
6.3
34
133
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
6.3
114
724
6403
FHL
Ileocal resection
+∞
6.3
6
*
JH1CM
NOMESCO Finland
Perianal extensive MRI with 3 Tesla magnet
+∞
6.3
6
*
JFA60
NOMESCO Finland
Stricturoplasty in small intestine
+∞
6.3
6
*
B04AD01, ,
ATC
27.2
6.3
8
*
NA6CG
NOMESCO Finland
Sacro-iliac joint extensive MRI examination with high intensity magnet
27.2
6.3
8
*
K92.1
ICD-10 Finland
Melaena
3.5
6.2
21
62
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.9
6.2
16
28
A06AD11
ATC
lactulose; oral
2.3
6.2
47
217
J01CA04
ATC
amoxicillin; systemic
2.1
6.2
323
2776
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.2
6.2
58
293
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
6.1
107
670
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
6.1
145
994
R4190
NOMESCO Finland
Nutritional therapy
3.7
6.1
19
53
B37.09
ICD-10 Finland
Unspecified candidal stomatitis
12.8
6.1
10
8
L12
ICPC
Hand/finger symptom/complaint
2.0
6.1
71
389
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
3.0
6.1
27
95
WX610
NOMESCO Finland
Patient controlled analgesia
10.3
6.1
11
11
S10
ICPC
Boil/carbuncle
2.8
6.1
31
118
A02BA03
ATC
famotidine; systemic
5.7
6.1
16
29
H15.1
ICD-10 Finland
Episcleritis
6.2
6.1
15
25
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.6
6.1
34
136
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.0
6.1
17
44
J01MA14
ATC
moxifloxacin; systemic
2.5
6.0
38
161

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
302
450
28.27
232.91
8.6
2.1
182.67
94.70
ug/g
4.34
288
356
223
342
14.26
158.89
2.3
1.3
—
—
—
0
0
331
1151
15.05
106.42
11.1
4.6
36.67
36.60
g/l
0.09
326
1093
348
1439
16.94
89.00
21.8
5.8
—
—
—
0
0
320
1243
10.70
85.64
4.7
2.3
71.96
75.17
nmol/l
1.45
315
1123
350
1518
16.59
83.14
21.0
5.3
0.59
0.55
e9/l
2.83
342
1345
350
1519
16.57
83.05
21.1
5.4
0.04
0.04
e9/l
1.40
342
1345
353
1575
17.35
80.48
21.0
5.8
0.17
0.18
e9/l
0.61
344
1416
351
1576
16.12
78.78
21.2
5.4
1.93
1.98
e9/l
0.21
345
1429
130
227
8.17
77.12
7.6
4.6
0.07
0.18
%
0.95
43
72
134
242
7.99
77.07
7.5
4.4
0.65
0.98
%
0.76
48
87
126
222
7.98
73.89
6.9
4.4
0.40
0.63
%
0.66
44
70
123
218
7.85
71.56
7.8
4.6
0.00
0.16
%
0.66
35
62
73
6
149.83
70.70
3.5
3.7
7.83
4.05
mg/l
—
55
6
353
1773
14.05
64.75
22.6
8.8
4.02
4.00
e9/l
0.07
343
1564
60
49
14.34
62.18
5.3
2.8
3.88
4.65
e9/l
1.08
60
49
60
50
14.05
61.42
5.3
3.2
57.67
57.00
%
0.12
60
50
206
673
5.47
60.94
4.7
2.0
2.82
2.86
mg/l
0.09
196
582
62
8
91.86
56.95
2.2
1.9
115.75
—
au/ml
—
7
0
152
454
4.90
48.36
1.6
1.4
696.00
465.35
titre
0.90
50
101
278
1359
4.84
44.79
21.9
8.4
0.00
0.00
e9/l
0.63
266
1115
364
2280
13.66
41.88
23.6
6.9
74.15
76.95
u/l
1.03
359
2152
355
2291
8.77
36.03
12.1
3.6
12.86
9.99
mm/h
4.71
349
2122
125
426
3.88
31.56
1.6
1.5
—
—
—
0
0
217
1058
3.43
31.11
2.3
1.8
95.29
97.26
pmol/l
0.26
155
525
113
365
3.98
30.74
2.4
2.3
20.32
25.03
%
2.77
102
317
26
0
+∞
27.42
2.2
0.0
2.84
—
mg/l
—
26
0
261
1494
3.36
27.34
6.8
4.6
0.00
0.00
estimate
0.50
82
291
257
1460
3.32
27.23
4.8
2.7
89.33
101.17
ug/l
0.67
249
1361
259
1490
3.29
26.61
5.5
3.3
0.00
0.00
estimate
0.50
85
305
261
1510
3.30
26.52
5.5
3.3
0.00
0.01
estimate
0.50
81
283
147
626
3.19
25.33
1.7
1.7
—
—
—
0
0
256
1513
3.10
24.11
7.5
6.0
9.85
10.57
umol/l
0.75
243
1448
70
193
4.22
23.26
1.5
1.2
—
—
—
0
0
132
559
3.08
22.57
1.4
1.3
12.47
8.19
u/ml
0.26
53
225
126
527
3.08
21.93
2.5
1.6
378.37
439.99
pmol/l
2.64
116
463
213
1181
2.82
21.84
13.0
9.3
1.09
1.14
inr
0.74
99
375
308
2106
3.39
20.91
6.9
3.8
—
—
—
0
0
156
753
2.81
20.66
14.7
6.3
—
—
—
0
0
223
1303
2.71
20.05
6.8
6.6
1.21
1.22
mmol/l
0.23
184
1118
75
241
3.63
19.91
2.0
2.4
11.65
10.47
g/l
1.51
67
220
158
780
2.75
19.88
6.4
3.5
0.00
0.01
estimate
0.80
82
289
141
662
2.79
19.50
5.0
4.1
—
—
—
0
0
131
592
2.85
19.48
1.4
1.3
20.47
29.88
iu/ml
0.85
42
196
157
785
2.70
19.12
4.1
3.8
7.39
7.40
ph
0.79
28
133
173
917
2.62
18.60
5.3
2.6
59.09
60.57
u/l
0.10
164
861
75
252
3.46
18.52
3.6
2.5
0.24
0.23
g/l
0.66
69
236
210
1226
2.58
18.38
4.8
3.1
5.28
5.81
ph
—
9
114
188
1051
2.55
17.90
5.3
3.2
28.61
30.74
u/l
0.92
172
998
124
567
2.76
17.80
3.4
2.4
5.63
6.66
e6/l
0.27
117
505
57
170
3.77
16.77
1.1
1.1
—
—
—
0
0
199
1179
2.44
16.24
5.9
5.8
1.22
1.22
mmol/l
0.10
181
1082
61
195
3.53
16.17
1.7
1.5
1.43
1.31
g/l
0.31
55
179
145
766
2.44
15.02
3.4
2.6
—
—
—
0
0
61
205
3.35
14.92
5.0
3.4
1.83
1.79
mmol/l
0.03
51
161
153
844
2.36
14.22
3.8
2.8
15.32
130.64
e6/l
0.84
132
630
174
1018
2.30
14.05
4.3
3.3
20.56
60.71
e6/l
1.33
142
685
88
382
2.69
13.61
2.6
2.1
—
—
—
0
0
90
397
2.66
13.47
1.2
1.2
—
—
—
0
0
140
767
2.30
13.00
3.8
2.7
0.28
0.46
e6/l
0.80
119
563
77
322
2.74
12.75
2.5
1.6
—
—
—
0
0
153
879
2.24
12.59
5.3
2.9
—
—
—
0
0
140
779
2.26
12.42
2.0
1.9
—
—
—
0
0
66
260
2.86
12.20
5.9
3.4
—
—
—
0
0
43
131
3.57
12.18
1.8
1.5
14.42
8.45
u/ml
—
5
6
92
429
2.51
12.18
2.0
1.6
1234.45
1229.61
nmol/l
0.02
71
322
134
738
2.26
12.14
2.2
2.3
3881.93
5823.45
umol/l
0.21
125
658
56
202
3.08
12.10
4.3
3.2
—
—
—
0
0
372
3201
7.19
11.66
37.0
11.3
12.41
20.59
mg/l
14.66
354
2461
236
1670
2.08
10.70
4.7
4.5
6.56
6.53
mmol/l
0.10
228
1526
38
119
3.44
10.30
2.1
1.6
—
—
—
0
0
103
541
2.24
10.23
3.7
2.6
533.14
549.35
mosm/kgh2o
0.27
94
468
64
272
2.63
10.15
3.0
2.4
33.80
29.55
u/l
0.65
54
222
68
300
2.54
9.99
6.9
6.2
104.71
104.42
mmol/l
0.18
68
300
30
84
3.79
9.58
1.8
2.0
2.84
1.62
ug/l
0.21
30
77
159
1020
1.96
9.05
3.3
3.0
19.14
36.56
ng/l
1.73
96
597
34
108
3.36
9.01
1.4
1.2
—
—
—
0
0
115
659
2.07
9.00
5.0
3.2
—
—
—
0
0
20
43
4.85
8.92
1.1
1.2
—
—
—
0
0
54
228
2.59
8.64
3.6
2.4
4.41
6.49
e9/l
0.63
45
201
21
33
6.67
8.61
1.5
1.3
—
—
—
0
0
106
598
2.07
8.61
1.8
1.4
17.78
21.47
nmol/l
2.10
95
512
180
1230
1.88
8.26
2.9
1.9
—
—
—
0
0
58
260
2.45
8.18
1.4
1.4
—
—
—
0
0
56
249
2.46
8.03
3.1
2.9
1.89
1.79
%
0.28
56
227
127
783
1.93
7.93
3.6
2.6
—
—
—
0
0
112
664
1.97
7.83
5.8
3.4
1.01
1.02
kg/l
0.47
11
91
27
83
3.42
7.53
1.6
1.3
293.80
300.57
ug/g
0.06
15
43
357
3147
3.05
7.35
22.4
12.4
139.14
139.70
mmol/l
4.56
350
3055
357
3154
3.02
7.18
22.4
12.5
3.90
3.95
mmol/l
3.38
350
3051
29
98
3.12
6.97
1.3
1.2
—
—
—
0
0
138
910
1.81
6.79
3.2
3.1
2.34
2.35
mmol/l
0.59
129
816
12
12
10.28
6.58
1.3
1.3
3183.29
1918.71
e6/l
—
7
7
68
357
2.10
6.55
1.5
1.4
—
—
—
0
0
41
173
2.53
6.55
2.1
2.9
78.31
73.88
e9/l
0.24
33
128
43
189
2.44
6.31
2.9
3.7
1.25
1.22
mmol/l
0.97
35
164
32
123
2.75
6.14
4.8
3.2
—
—
—
0
0
35
144
2.57
5.89
2.8
2.9
0.23
0.11
e6/l
0.71
35
138
43
196
2.35
5.83
8.2
8.0
8.41
8.75
mmol/l
0.12
43
190
20
60
3.46
5.80
1.1
1.2
—
—
—
0
0
255
2059
1.72
5.72
3.5
3.3
—
—
—
0
0
20
61
3.40
5.66
1.4
1.2
385.58
202.58
u/ml
1.14
12
31
289
2426
1.79
5.54
4.1
3.9
14.80
14.47
pmol/l
1.38
263
2231
17
48
3.66
5.39
5.6
2.5
6.92
7.33
mmol/l
0.30
17
48
107
696
1.75
5.32
1.8
1.6
0.76
0.93
mg/l
0.56
87
528
73
424
1.89
5.25
2.7
2.5
2.44
2.63
e6/l
0.08
45
219
41
192
2.27
5.23
4.7
7.4
—
—
—
0
0
10
12
8.52
5.09
1.8
1.3
27.70
28.92
umol/l
—
10
12
17
51
3.44
4.94
5.6
2.4
1.51
1.31
mmol/l
0.72
17
51
327
2889
1.92
4.81
4.8
4.6
1.78
1.83
mu/l
0.27
306
2689
8
7
11.64
4.80
1.6
1.6
—
—
—
0
0
29
121
2.51
4.77
1.6
1.2
—
—
—
0
0
33
147
2.36
4.72
1.2
2.5
—
—
—
0
0
34
155
2.31
4.62
5.7
7.8
—
—
—
0
0
105
704
1.68
4.60
1.7
1.3
3.00
2.28
g/l
1.96
72
456
22
82
2.79
4.50
2.4
2.4
—
—
—
0
0
14
32
4.50
4.48
1.7
1.3
—
—
—
0
0
364
3369
2.71
4.41
24.2
10.8
—
—
—
0
0
16
50
3.30
4.38
1.1
1.5
—
—
—
0
0
129
924
1.60
4.31
2.8
2.1
—
—
—
0
0
110
762
1.62
4.20
3.3
3.2
—
—
—
0
0
35
174
2.11
3.89
3.9
2.1
—
—
—
0
0
12
28
4.39
3.85
1.0
1.4
—
—
—
0
0
7
8
8.88
3.78
1.3
1.0
—
—
—
0
0
7
8
8.88
3.78
1.9
2.3
52.14
58.06
%
—
7
8
116
834
1.56
3.73
2.0
2.1
123.78
287.82
u/l
1.34
111
795
60
366
1.76
3.65
1.5
1.2
—
—
—
0
0
376
3609
3.66
3.62
47.4
16.9
278.37
255.33
e9/l
8.57
371
3536
376
3607
3.70
3.62
46.8
16.8
40.30
40.73
%
0.78
360
3401
376
3613
3.59
3.47
47.4
16.8
4.45
4.55
e12/l
4.27
371
3536
376
3614
3.57
3.47
47.4
16.9
7.06
6.62
e9/l
4.07
371
3533
16
58
2.84
3.46
1.8
1.5
—
—
—
0
0
22
459
0.45
3.46
1.1
1.3
—
—
—
0
0
11
28
4.01
3.31
2.2
2.5
—
—
—
0
0
13
43
3.09
3.28
3.0
2.1
—
—
—
0
0
46
268
1.81
3.27
6.3
9.1
1.29
1.15
mmol/l
0.08
38
213
34
179
1.99
3.26
2.3
2.2
4556.68
2783.97
u/l
0.22
12
71
17
66
2.65
3.26
2.9
1.7
—
—
—
0
0
9
19
4.82
3.25
1.0
1.1
—
—
—
0
0
11
29
3.87
3.21
1.2
1.7
1.83
3.77
u/field
—
6
13
178
1439
1.44
3.11
3.0
2.5
—
—
—
0
0
106
782
1.49
2.95
1.3
1.3
0.98
1.36
u/ml
0.46
23
217
30
158
1.98
2.89
2.6
3.5
90.57
85.19
ng/l
0.08
24
144
56
358
1.66
2.89
4.7
2.7
5.07
7.16
umol/l
1.31
51
309
11
33
3.40
2.83
1.0
1.4
—
—
—
0
0
10
29
3.51
2.71
4.3
2.4
—
—
—
0
0
21
100
2.16
2.64
1.1
1.3
—
—
—
0
0
11
36
3.12
2.58
1.2
1.4
—
—
—
0
0
8
20
4.06
2.58
1.0
1.1
—
—
—
0
0
5
7
7.22
2.55
1.6
2.0
—
—
—
0
0
9
26
3.52
2.49
1.1
1.3
—
—
nmol/l
—
0
0
37
222
1.74
2.42
1.2
1.2
79.08
262.05
u/ml
0.97
32
204
13
52
2.55
2.38
2.8
2.4
—
—
—
0
0
8
22
3.69
2.37
2.3
1.2
—
—
—
0
0
15
65
2.36
2.34
5.6
4.2
—
—
—
0
0
57
388
1.55
2.29
1.7
1.9
30.06
29.30
s
0.60
57
378
9
29
3.15
2.24
2.3
3.0
—
—
—
0
0
8
24
3.38
2.19
1.3
2.0
—
—
—
0
0
8
24
3.38
2.19
2.1
2.1
41.18
37.45
%
—
8
24
16
75
2.18
2.11
1.4
1.2
—
—
—
0
0
25
139
1.85
2.10
4.1
5.7
26.44
24.57
mmol/l
1.27
25
139
9
31
2.95
2.08
1.3
3.6
—
—
—
0
0
9
32
2.86
2.01
1.0
1.3
—
—
—
0
0
7
21
3.38
1.97
1.1
1.2
—
—
—
0
0
5
11
4.59
1.94
1.0
1.1
—
—
—
0
0
6
16
3.79
1.94
1.5
1.4
132.00
157.16
nmol/l
—
6
16
11
46
2.43
1.87
1.2
4.9
—
—
—
0
0
5
12
4.21
1.83
4.4
3.3
—
—
—
0
0
16
80
2.04
1.82
3.6
3.1
1.37
1.49
mg/l
0.27
16
74
6
18
3.37
1.75
1.0
1.1
—
—
—
0
0
15
277
0.52
1.70
1.3
1.4
—
—
—
0
0
5
14
3.60
1.62
1.8
1.4
—
—
—
0
0
7
26
2.72
1.58
1.3
1.8
34.14
33.12
pg
—
7
26
6
20
3.03
1.58
1.3
1.1
—
—
—
0
0
5
15
3.36
1.53
8.2
7.3
—
—
—
0
0
25
155
1.66
1.51
2.8
2.8
4.75
5.09
kpa
1.76
25
149
30
197
1.57
1.45
2.1
3.4
80.65
76.38
ng/l
0.08
25
179
5
16
3.15
1.44
1.8
5.6
—
—
—
0
0
61
465
1.37
1.40
1.8
1.7
—
—
—
0
0
10
47
2.16
1.35
1.1
1.1
—
—
—
0
0
5
20
2.52
1.15
2.0
3.0
37280.00
38590.00
ug/l
—
5
20
7
30
2.36
1.13
1.4
1.5
92.54
91.63
%
—
7
30
8
40
2.02
1.12
1.9
2.5
—
—
—
0
0
16
96
1.70
1.12
6.4
4.0
—
—
—
0
0
37
271
1.40
1.10
3.6
4.5
3.26
25.14
ug/l
0.74
26
215
29
203
1.46
1.09
1.7
1.4
—
—
—
0
0
5
22
2.29
1.03
1.2
1.1
—
—
—
0
0
5
22
2.29
1.03
1.2
1.0
—
—
—
0
0
12
68
1.79
1.01
1.5
2.0
1.25
0.88
nmol/l
0.59
12
60
9
49
1.86
0.99
1.8
1.9
—
—
—
0
0
5
23
2.19
0.98
3.0
1.3
0.83
1.11
g/l
—
5
23
0
31
0.00
0.97
0.0
9.3
—
0.59
—
0
31
7
37
1.91
0.94
1.0
1.3
—
—
—
0
0
56
450
1.29
0.93
1.8
1.4
—
—
—
0
0
6
28
2.16
0.92
1.8
2.9
3.20
2.86
nmol/l
—
6
28
16
238
0.66
0.86
1.6
1.7
—
—
—
0
0
312
2992
1.23
0.84
4.0
3.9
5.84
5.80
mmol/l
0.27
288
2782
32
417
0.75
0.83
2.4
2.6
0.69
0.71
ug/l
0.04
17
227
6
34
1.78
0.76
1.2
1.2
—
—
—
0
0
9
56
1.62
0.73
2.3
2.7
5.04
4.97
kpa
—
9
56
9
56
1.62
0.73
2.3
2.7
9.54
9.07
kpa
—
9
56
9
57
1.59
0.71
1.1
1.1
—
—
—
0
0
9
57
1.59
0.71
3.6
3.7
43.89
36.14
umol/l
—
9
51
9
58
1.56
0.70
1.1
1.1
—
—
—
0
0
292
2800
1.18
0.69
5.5
5.0
38.01
38.96
mmol/mol
1.09
278
2650
242
2289
1.16
0.68
4.6
3.1
57.37
43.17
u/l
1.47
232
2179
18
128
1.43
0.67
7.5
12.7
—
—
—
0
0
59
499
1.22
0.66
4.1
3.5
21.99
445.79
ng/l
1.94
42
335
19
137
1.41
0.66
1.5
1.3
230.01
268.40
miu/ml
0.20
12
71
7
44
1.60
0.65
1.7
1.2
—
—
—
0
0
5
29
1.73
0.64
16.2
11.5
6.26
6.98
mmol/l
—
5
22
0
21
0.00
0.60
0.0
1.7
—
—
—
0
0
10
64
1.58
0.59
1.4
1.4
—
—
—
0
0
6
35
1.73
0.58
1.2
1.0
—
—
titre
—
0
0
17
125
1.38
0.54
1.8
2.1
—
—
—
0
0
9
61
1.49
0.54
1.1
1.3
—
—
—
0
0
9
62
1.46
0.53
1.7
2.0
—
—
—
0
0
10
66
1.53
0.53
2.2
2.8
7.43
7.42
ph
—
10
58
14
100
1.42
0.52
1.3
1.1
—
—
—
0
0
7
108
0.64
0.49
1.0
1.4
—
—
—
0
0
7
109
0.64
0.49
1.0
1.4
—
—
—
0
0
7
110
0.63
0.49
1.0
1.6
—
—
—
0
0
33
394
0.82
0.46
1.4
1.8
—
—
—
0
0
7
50
1.41
0.45
1.4
3.0
—
—
—
0
0
19
148
1.30
0.44
3.2
3.2
—
—
—
0
0
12
87
1.39
0.42
1.3
1.9
1.97
6.46
iu/l
—
7
33
5
32
1.57
0.42
1.2
1.2
116.10
187.06
pmol/l
—
5
32
29
241
1.22
0.41
2.9
4.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
63826.67
—
0
6
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
11
80
1.39
0.39
1.9
2.4
—
—
—
0
0
11
82
1.35
0.34
1.3
1.1
—
—
—
0
0
88
812
1.11
0.34
1.8
1.6
1.84
1.42
mmol/l
1.42
80
699
7
52
1.35
0.31
1.1
1.3
—
—
—
0
0
7
55
1.28
0.30
1.0
1.0
—
0.78
—
0
25
9
120
0.74
0.27
1.9
1.6
—
—
—
0
0
136
1298
1.07
0.25
2.9
2.6
—
—
—
0
0
14
168
0.83
0.23
1.2
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
3.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
6
52
1.16
0.19
1.3
1.1
—
—
—
0
0
76
718
1.07
0.19
3.1
3.4
855.96
254.06
mg/l
0.35
58
464
13
109
1.20
0.19
2.8
2.9
—
—
—
0
0
7
59
1.19
0.18
1.0
1.1
—
12.87
—
0
6
13
152
0.85
0.17
1.2
1.5
207.31
294.65
mu/l
1.93
13
133
8
69
1.16
0.16
1.1
2.4
43.15
39.38
g/l
—
8
64
80
763
1.06
0.15
3.9
3.9
16.16
10.69
mg/mmol
0.22
59
480
309
3123
0.94
0.14
4.0
3.9
1.41
1.48
mmol/l
2.17
285
2934
19
170
1.12
0.13
1.7
2.2
—
—
—
0
0
88
849
1.05
0.12
3.3
3.2
7.49
8.02
mmol/l
0.57
79
737
315
3178
0.95
0.11
4.4
4.4
2.67
2.87
mmol/l
3.77
292
2984
5
44
1.14
0.10
1.0
1.1
—
4.08
—
0
20
5
46
1.09
0.09
1.4
2.0
—
—
—
0
0
9
88
1.02
0.07
1.6
1.8
235.22
235.94
pmol/l
—
9
83
20
213
0.94
0.06
2.3
2.0
—
—
—
0
0
20
212
0.94
0.05
2.2
2.0
—
—
—
0
0
20
212
0.94
0.05
2.2
2.0
—
—
—
0
0
20
212
0.94
0.05
2.3
1.9
—
—
—
0
0
11
101
1.09
0.04
2.0
2.8
—
—
—
0
0
301
3020
0.98
0.02
3.7
3.6
1.51
1.29
mmol/l
4.04
277
2827
24
232
1.04
0.02
1.7
1.3
—
—
—
0
0
314
3133
1.01
0.01
4.1
4.0
4.61
4.78
mmol/l
2.34
294
2956
19
192
0.99
0.00
1.2
1.2
—
—
—
0
0
96
962
1.00
0.00
1.5
1.6
—
—
—
0
0
10
105
0.95
0.00
18.3
6.9
—
—
—
0
0
29
285
1.02
0.00
1.1
1.2
—
—
—
0
0
34
335
1.02
0.00
1.7
1.4
—
—
—
0
0
27
274
0.98
0.00
1.2
1.3
42.46
174.91
iu/ml
5.09
11
111
20
196
1.02
0.00
2.1
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
56
0.89
-0.00
1.0
1.1
—
1.43
—
0
30
0
8
0.00
-0.00
0.0
1.4
—
1.84
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
6.38
—
0
6
7
75
0.93
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.03
—
0
7
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
2.90
—
0
7
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
65
0.92
-0.00
1.8
1.5
—
—
—
0
0
7
75
0.93
-0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
13.51
—
0
9
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CROHN_ARTHR and mortality.

Females

Parameter HR [95% CI] p-value
CROHN_ARTHR 1.408 [1.06, 1.87] 0.018
Birth year 0.991 [0.98, 1.0] 0.035

During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 730 females with CROHN_ARTHR died.

Males

Parameter HR [95% CI] p-value
CROHN_ARTHR 1.394 [1.06, 1.83] 0.018
Birth year 0.985 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 562 males with CROHN_ARTHR died.

Mortality risk

Mortality risk for people of age

years, who have CROHN_ARTHR.

N-year risk Females Males
1 0.125% 0.215%
5 0.773% 1.587%
10 1.813% 3.786%
15 3.506% 7.126%
20 5.89% 11.945%

Relationships between endpoints

Index endpoint: CROHN_ARTHR – Arthropathy in Crohn disease

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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