No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
527 |
4. Check minimum number of eventsNone |
527 |
5. Include endpointsNone |
527 |
6. Filter based on genotype QC (FinnGen only) |
511 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H53
- Name in latin
- Aliae perturbationes visus binocularis
Similar endpoints
↥List of similar endpoints to
Other disorders of binocular vision
based on the number of shared cases.
Similar with more cases:
- Visual disturbances
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4069 | 2676 | 1389 |
| Only index persons | 3914 | 2593 | 1321 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.08 | 0.04 |
| Only index persons | 0.08 | 0.10 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 24.72 | 24.46 | 25.21 |
| Only index persons | 25.18 | 24.84 | 25.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 511 | 391 | 120 |
| Unadjusted period prevalence (%) | 0.12 | 0.14 | 0.05 |
| Median age at first event (years) | 34.56 | 31.77 | 43.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 527
- Matched controls
- 5270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H53.3
ICD-10 Finland
Other disorders of binocular vision
4503599627370496.0
307.7
523
*
H51.1
ICD-10 Finland
Convergence insufficiency and excess
375.4
120.6
117
*
H50.52
ICD-10 Finland
Exophoria
43.2
111.9
68
18
H53.1
ICD-10 Finland
Subjective visual disturbances
16.5
77.2
68
47
WX704
NOMESCO Finland
Intubation
6.8
61.8
110
196
WX725
NOMESCO Finland
Noninvasive ventilation
7.9
55.5
83
122
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
51.3
160
463
H53.2
ICD-10 Finland
Diplopia
120.1
50.8
54
5
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
7.7
41.1
61
88
SPAT1301
SPAT
No procedures
3.1
35.3
234
1074
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.9
34.4
121
373
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.8
33.3
84
201
WX720
NOMESCO Finland
Own respiration
6.3
33.2
59
103
Z01.8
ICD-10 Finland
Other specified special examinations
3.3
31.7
162
633
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
29.6
150
580
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.9
28.5
96
285
N03AX12
ATC
[U] gabapentin; oral
3.4
28.5
122
425
SPAT1324
SPAT
Screening procedure
2.9
27.3
176
776
SPAT1263
SPAT
Sampling
2.7
27.2
291
1658
R51.80
ICD-10 Finland
Headache
2.9
25.1
147
611
WX702
NOMESCO Finland
Supraglottic ventilation device
4.7
23.6
59
139
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
3.9
23.2
74
210
A02BC03
ATC
lansoprazole; oral
2.5
19.8
163
795
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.9
18.8
60
170
R03BA08
ATC
ciclesonide; inhalant
3.3
17.5
72
241
R02
ICPC
Shortness of breath/dyspnoea
3.0
17.2
85
317
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.6
16.4
58
176
H53.0
ICD-10 Finland
Amblyopia ex anopsia
62.0
15.9
18
*
A45
ICPC
General and Unspecified, Observ/health educat/advice/diet
5.8
15.7
29
52
XCK00
NOMESCO Finland
Perimetry
4.7
15.4
37
84
SPAT1097
SPAT
Recording of ECG
3.0
15.3
76
283
A02BC05
ATC
esomeprazole; systemic
2.1
15.1
216
1302
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.6
15.1
105
467
H53.4
ICD-10 Finland
Visual field defects
58.4
14.9
17
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
3.5
14.5
53
164
-, ,
ICD-10 Finland
10.9
14.4
27
26
SPAT1310
SPAT
Counselling related to known health issue
2.1
14.3
204
1222
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.1
14.3
65
230
R42
ICD-10 Finland
Dizziness and giddiness
2.4
14.2
112
526
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
14.1
60
204
H50.31
ICD-10 Finland
Intermittent exotropia
11.9
13.9
25
22
AA1AD
NOMESCO Finland
CT of head and brain
2.3
13.8
121
596
WX234
NOMESCO Finland
Paracervical blockade
3.6
13.8
47
139
N06AX21
ATC
duloxetine; oral
2.6
13.5
85
358
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.0
13.5
40
107
R03CC03
ATC
terbutaline; systemic
4.3
13.5
36
89
R96
ICPC
Asthma
3.0
13.4
62
222
XMA22
NOMESCO Finland
General examination of pregnant woman
2.9
12.8
65
245
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.7
12.8
78
324
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.2
12.7
125
645
H53.9
ICD-10 Finland
Visual disturbance, unspecified
9.7
12.6
25
27
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.3
12.6
49
158
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.8
12.4
66
255
D07AB02
ATC
hydrocortisone butyrate; topical
2.0
12.2
173
1024
N02BF01
ATC
gabapentin; oral
3.0
12.2
55
194
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
18.6
12.1
18
10
H50.2
ICD-10 Finland
Vertical strabismus
27.4
12.1
16
6
R09
ICPC
Sinus symptom/complaint
2.5
12.0
81
353
R03AC02
ATC
salbutamol; inhalant
1.9
11.9
324
2382
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.3
11.8
103
503
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
11.7
198
1242
N02AX02
ATC
tramadol; systemic, rectal
1.9
11.7
203
1285
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
9.6
11.6
23
25
SAA03
NOMESCO Finland
Extended examination of mouth
1.9
11.5
255
1746
N06AX11
ATC
mirtazapine; oral
1.9
11.3
189
1178
H50.1
ICD-10 Finland
Divergent concomitant strabismus
35.9
11.3
14
*
H50.51
ICD-10 Finland
Esophoria
35.9
11.3
14
*
OAB47, ,
SPAT
3.3
11.1
43
138
G44.2
ICD-10 Finland
Tension-type headache
2.3
11.1
101
502
SPAT1081
SPAT
Cardiorespiratory global assessment
4.2
11.1
30
75
MBC10
NOMESCO Finland
Repair of obstetric laceration of vagina
3.6
11.0
37
108
CEC00
NOMESCO Finland
Recession of extraocular muscle
44.3
11.0
13
*
H02AB06
ATC
prednisolone; systemic
1.9
10.9
235
1587
N03AF02
ATC
oxcarbazepine; oral
4.1
10.9
30
76
H04.10
ICD-10 Finland
Dry eye syndrome
2.5
10.7
72
312
SPAT1260
SPAT
Consultation of another employee
2.2
10.7
106
544
SPAT1058
SPAT
PEF monitoring instruction
3.0
10.7
49
174
N03AE01
ATC
clonazepam; systemic
3.5
10.6
38
116
SPAT1044
SPAT
Tympanometry
4.3
10.5
27
65
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.3
10.3
85
405
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.8
10.1
52
197
N03AG01
ATC
valproic acid; systemic, rectal
2.9
9.9
47
170
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
9.8
220
1492
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.1
9.7
108
580
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.7
9.6
56
226
D02
ICPC
Abdominal pain epigastric
2.9
9.6
48
179
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.6
9.6
56
227
A31
ICPC
General and Unspecified, Medical examin/health eval partial
3.7
9.5
30
84
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.4
9.5
35
109
R03AK08
ATC
formoterol and beclometasone; inhalant
3.5
9.5
33
99
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.4
9.0
33
102
R01AD09
ATC
mometasone; nasal
1.8
9.0
266
1939
K07.60
ICD-10 Finland
Snapping jaw
2.7
9.0
49
191
N06AA09
ATC
amitriptyline; systemic
2.7
8.9
49
192
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.3
8.9
74
353
A78
ICPC
Infectious disease other/NOS
3.8
8.8
27
74
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
8.8
127
745
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
3.7
8.8
28
79
D06
ICPC
Abdominal pain localized other
2.5
8.8
60
262
Z31.5
ICD-10 Finland
Genetic counselling
2.7
8.5
47
185
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
2.2
8.5
82
416
G03DB01
ATC
dydrogesterone; oral
2.1
8.4
87
452
M01AH03
ATC
valdecoxib; oral
3.3
8.4
32
102
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
3.6
8.4
27
77
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.3
8.3
21
50
G54.0
ICD-10 Finland
Brachial plexus disorders
3.7
8.2
26
73
N03AX11
ATC
topiramate; oral
3.7
8.2
26
73
S01GX08
ATC
ketotifen; ophthalmic
2.9
8.2
38
136
TPH07
NOMESCO Finland
Cathetrisation of artery
2.7
8.2
45
177
R01AD58
ATC
fluticasone, combinations; nasal
1.8
8.1
165
1074
JN3AD
NOMESCO Finland
Abdominal CT examination
2.5
8.1
54
233
A02BA02
ATC
ranitidine; systemic
2.1
8.1
84
438
F05
ICPC
Visual disturbance other
4.0
8.1
23
60
R03BA01
ATC
beclometasone; inhalant
2.1
8.0
77
389
C07AA05
ATC
propranolol; systemic
1.9
8.0
130
790
R03AK07
ATC
formoterol and budesonide; inhalant
1.9
7.9
116
681
ZXE00
NOMESCO Finland
One hour or less
0.5
7.9
80
1405
SAA04
NOMESCO Finland
Special examination of mouth
2.7
7.9
43
168
R06AX27
ATC
desloratadine; oral
1.7
7.9
192
1315
J01DA09
ATC
[U] cefadroxil
1.8
7.9
149
949
M01AH01
ATC
celecoxib; oral
2.1
7.9
78
399
J01EA01
ATC
trimethoprim; systemic
1.8
7.9
144
908
UJF32
NOMESCO Finland
Coloscopy
1.9
7.8
104
591
OAB50, ,
SPAT
3.2
7.8
31
101
F45.8
ICD-10 Finland
Other somatoform disorders
2.3
7.8
60
277
H52.5
ICD-10 Finland
Disorders of accommodation
45.7
7.7
9
*
S06.0
ICD-10 Finland
Concussion
2.2
7.7
68
332
SPAT1153
SPAT
Removal of sutures
1.8
7.7
137
856
-1, ,
NOMESCO Finland
1.7
7.7
218
1553
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
7.7
220
1572
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
6.9
7.6
18
27
N03AX16
ATC
[U] pregabalin
1.9
7.6
109
635
XA800
NOMESCO Finland
Neuropsychological investigation
3.1
7.6
31
103
KMAK, ,
NOMESCO Finland
1.7
7.6
297
2299
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
7.6
158
1034
WX402
NOMESCO Finland
General anaesthesia
1.9
7.5
112
662
L12
ICPC
Hand/finger symptom/complaint
1.9
7.4
98
555
HAMTE, ,
NOMESCO Finland
7.8
7.4
16
21
R20.2
ICD-10 Finland
Paraesthesia of skin
2.5
7.4
46
192
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.4
7.4
54
243
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.6
7.4
44
180
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.7
7.4
23
64
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.3
7.3
27
84
A30
ICPC
General and Unspecified, Medical examin/health eval complete
3.9
7.3
21
55
N17
ICPC
Vertigo/dizziness
2.2
7.2
60
286
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
7.2
78
413
WX400
NOMESCO Finland
Inhalation anesthesy
2.9
7.1
34
124
LX2A3, ,
SPAT
3.6
7.1
23
66
R44
ICPC
Respiratory, Preventive immunization/medic
10.2
7.1
13
13
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.3
7.0
55
255
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
7.0
178
1224
TAB00
NOMESCO Finland
Lumbar puncture
3.0
7.0
31
108
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
7.0
217
1572
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.1
6.9
19
48
A11
ICPC
Chest pain NOS
2.6
6.9
40
161
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.9
6.9
32
115
G43.9
ICD-10 Finland
Migraine, unspecified
2.2
6.8
56
265
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
6.8
111
672
N05BA01
ATC
diazepam; systemic, rectal
2.1
6.8
67
341
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
4.4
6.8
17
40
S06
ICPC
Rash localized
2.8
6.7
33
122
N06AB10
ATC
escitalopram; oral
1.7
6.7
139
903
M25.5
ICD-10 Finland
Pain in joint
1.7
6.7
170
1167
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.5
6.7
41
170
R55
ICD-10 Finland
Syncope and collapse
2.3
6.7
51
234
XPX04
NOMESCO Finland
Angioscopy
22.8
6.7
9
*
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
6.7
95
551
L86
ICPC
Back syndrome with radiating pain
2.7
6.7
37
146
A02BX02
ATC
sucralfate; oral
4.1
6.7
18
45
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
3.1
6.6
28
95
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
12.4
6.6
11
9
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
8.9
6.6
13
15
SBB10
NOMESCO Finland
Dental impressions
2.2
6.5
56
270
-31
ICPC
Medical examin/health eval partial
2.5
6.5
40
166
R06AX22
ATC
ebastine; oral
1.9
6.5
97
571
N05AH04
ATC
quetiapine; oral
1.8
6.5
112
690
L04AX01
ATC
azathioprine; systemic
3.1
6.5
27
91
C07AB07
ATC
bisoprolol; oral
1.7
6.4
173
1204
C09CA06
ATC
candesartan; oral
1.8
6.4
102
613
D01
ICPC
Abdominal pain/cramps general
1.9
6.4
80
445
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
6.1
6.3
16
27
JAH01
NOMESCO Finland
Laparoscopy
2.9
6.3
30
109
XKC03
NOMESCO Finland
Water cystometry
3.9
6.3
18
47
N06AX26
ATC
vortioxetine; oral
2.2
6.3
52
247
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.8
6.3
31
115
N03AX09
ATC
lamotrigine; oral
2.5
6.3
39
163
XLD10
NOMESCO Finland
Gynaecological examination
6.4
6.2
15
24
A02BC04
ATC
rabeprazole; oral
2.2
6.2
52
249
M79.7
ICD-10 Finland
Fibromyalgia
3.0
6.1
27
94
E0000UV, ,
ATC
1.6
6.1
218
1620
H52.0
ICD-10 Finland
Hypermetropia
4.2
6.1
16
39
K24
ICPC
Fear of heart disease
4.0
6.0
17
44
M54.2
ICD-10 Finland
Cervicalgia
2.2
6.0
51
245
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
6.0
153
1047
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
148
580
3.16
28.44
3.4
2.9
36.78
242.01
ng/l
2.20
77
348
73
181
4.52
27.55
2.7
2.4
66.98
115.52
ng/l
1.16
66
155
197
952
2.71
25.29
4.1
3.2
1.02
1.02
kg/l
0.07
21
126
216
1156
2.47
21.76
2.8
2.3
53.27
57.49
u/l
0.82
206
1077
89
335
2.99
17.73
2.0
1.8
—
—
—
0
0
86
328
2.94
16.69
1.9
1.7
—
—
—
0
0
178
967
2.27
16.44
2.9
1.9
115.43
246.28
u/l
1.19
170
912
233
1429
2.13
15.71
6.6
4.0
36.86
36.76
g/l
0.11
224
1344
77
288
2.96
15.43
3.9
8.4
2.11
1.16
mmol/l
1.29
53
227
312
2152
2.10
15.21
4.3
4.1
6.09
6.36
mmol/l
1.68
271
1925
102
447
2.59
15.08
1.9
2.3
28.14
29.24
s
1.27
93
435
253
1634
2.05
14.53
6.0
5.7
1.21
1.22
mmol/l
0.79
223
1388
227
1413
2.07
14.39
8.8
9.0
1.07
1.13
inr
0.55
50
461
391
3005
2.17
13.48
4.8
3.6
10.03
9.30
mm/h
0.55
384
2807
271
1884
1.90
11.75
5.3
5.3
9.55
10.20
umol/l
0.90
261
1787
22
41
5.56
11.44
1.3
1.4
—
—
—
0
0
22
41
5.56
11.44
1.3
1.4
—
—
—
0
0
377
2943
1.99
11.28
7.4
6.3
69.48
73.46
u/l
1.98
365
2760
318
3914
0.53
11.03
9.6
9.0
90.78
91.96
ml/min/173m2
0.48
247
3072
70
298
2.56
10.84
1.5
1.3
118.09
173.55
u/ml
0.84
63
276
81
372
2.39
10.66
6.7
5.3
—
—
—
0
0
98
502
2.17
9.93
2.1
1.8
—
—
—
0
0
416
3460
1.96
9.05
5.2
4.0
14.50
14.40
pmol/l
0.45
397
3205
55
228
2.58
8.98
1.6
1.6
—
—
—
0
0
203
1378
1.77
8.78
4.3
2.8
25.36
28.87
u/l
2.11
197
1320
22
52
4.37
8.74
1.7
1.5
—
—
—
0
0
92
500
2.02
7.88
3.1
3.2
0.83
0.82
mmol/l
0.27
87
475
209
1465
1.71
7.86
4.5
5.3
1.21
1.22
mmol/l
1.17
200
1347
232
1674
1.69
7.83
4.1
3.1
—
—
—
0
0
28
86
3.38
7.77
2.7
1.9
13.60
13.13
%
0.69
28
86
471
4166
2.23
7.64
15.2
10.6
139.75
139.58
mmol/l
0.91
464
4053
45
956
0.42
7.42
2.2
1.9
—
—
—
0
0
471
4181
2.19
7.33
15.3
10.6
3.92
3.92
mmol/l
0.03
464
4053
290
2251
1.64
7.14
3.2
2.8
80.75
79.46
ug/l
0.05
284
2110
22
61
3.72
7.10
1.3
1.6
—
—
—
0
0
22
61
3.72
7.10
1.3
1.6
—
—
—
0
0
116
706
1.82
7.03
1.5
1.6
134862873.55
41774617.90
pmol/l
0.46
109
620
81
442
1.98
6.83
2.2
2.2
6509.49
4989.75
u/l
0.21
23
183
147
974
1.71
6.60
2.4
2.0
2.17
2.79
mg/l
3.39
137
826
277
2159
1.60
6.46
4.0
3.1
0.00
0.01
estimate
0.50
33
419
454
4031
1.91
6.24
6.1
4.6
1.74
2.05
mu/l
0.56
441
3783
273
2133
1.58
6.21
4.1
3.1
0.00
0.00
estimate
0.50
33
446
18
48
3.85
6.13
1.2
1.5
—
—
—
0
0
62
320
2.06
6.09
3.7
3.3
4.75
4.57
pmol/l
0.55
57
283
479
4344
2.13
6.00
15.0
10.3
18.68
19.95
mg/l
0.42
378
3332
17
34
5.13
5.92
1.1
1.6
—
—
—
0
0
186
1346
1.59
5.78
1.8
1.7
96.62
96.52
pmol/l
0.01
90
709
69
379
1.94
5.69
2.0
1.8
359.75
380.26
nmol/l
0.34
63
358
51
255
2.11
5.45
1.8
2.1
—
—
—
0
0
13
21
6.32
5.41
3.1
2.1
—
—
—
0
0
269
2137
1.53
5.41
5.3
4.3
0.00
0.00
estimate
0.50
34
433
53
273
2.05
5.24
1.6
1.7
—
—
—
0
0
117
773
1.66
5.19
1.3
1.3
20.51
28.57
iu/ml
0.68
51
243
18
55
3.35
5.07
1.2
1.5
—
—
—
0
0
289
2351
1.51
5.06
10.1
8.2
4.02
3.96
e9/l
0.22
273
2060
84
517
1.74
4.82
1.6
1.6
1189.75
1170.23
nmol/l
0.08
75
411
28
115
2.52
4.71
1.5
2.0
—
—
—
0
0
44
221
2.08
4.66
1.4
1.4
—
—
—
0
0
112
751
1.62
4.65
1.3
1.3
8.16
7.85
u/ml
0.02
47
298
22
82
2.76
4.47
1.3
1.5
—
—
—
0
0
46
240
2.00
4.41
1.5
1.5
—
—
—
0
0
56
316
1.86
4.28
1.4
1.5
—
—
—
0
0
250
2028
1.44
4.14
3.1
2.4
—
—
—
0
0
12
26
4.70
4.08
1.1
1.1
0.95
1.18
u/l
—
6
13
21
84
2.56
3.76
1.3
1.5
—
—
—
0
0
12
29
4.21
3.72
1.2
1.1
—
—
—
0
0
90
604
1.59
3.69
2.6
1.8
—
—
—
0
0
16
394
0.39
3.67
1.8
1.5
—
—
—
0
0
14
40
3.57
3.63
1.1
1.2
—
—
—
0
0
14
40
3.57
3.63
1.1
1.2
—
—
—
0
0
14
364
0.37
3.62
1.8
1.4
—
—
—
0
0
14
363
0.37
3.60
1.7
1.4
—
—
—
0
0
14
363
0.37
3.60
1.8
1.4
—
—
—
0
0
484
4534
1.83
3.60
10.9
8.2
24.97
25.06
u/l
0.04
479
4395
14
362
0.37
3.58
1.7
1.4
—
—
—
0
0
430
3916
1.53
3.55
4.0
3.5
5.55
5.68
mmol/l
1.36
414
3638
432
3945
1.53
3.44
19.1
12.5
13.96
14.21
%
0.56
426
3889
8
14
5.78
3.35
1.6
2.0
82.55
60.54
ug/l
—
8
14
131
981
1.45
3.19
1.9
1.7
1.41
1.35
mmol/l
0.39
126
847
55
339
1.69
3.16
3.8
5.9
104.76
104.38
mmol/l
0.22
55
339
122
903
1.46
3.16
1.9
1.9
0.96
0.92
mg/l
0.06
95
662
202
1636
1.38
3.14
2.6
2.2
75.46
74.17
nmol/l
0.28
194
1500
340
2993
1.38
3.13
3.3
2.8
34.93
37.23
u/l
0.43
331
2864
27
133
2.09
3.07
2.2
1.9
2.32
5.01
iu/l
1.72
13
53
12
36
3.39
3.03
1.1
1.1
—
—
—
0
0
30
542
0.53
3.00
3.4
2.5
1.25
3.23
e6/l
2.80
15
288
151
1175
1.40
2.95
3.2
2.9
2.32
2.35
mmol/l
3.46
141
1064
106
774
1.46
2.93
1.5
1.4
20.20
20.87
nmol/l
0.20
100
673
43
254
1.75
2.88
2.1
3.7
2.03
1.73
mmol/l
0.29
32
201
8
19
4.26
2.68
1.0
1.1
—
—
—
0
0
391
3560
1.38
2.67
4.4
4.4
37.06
38.03
mmol/mol
1.76
384
3353
145
1142
1.37
2.60
4.6
3.3
0.00
0.01
estimate
1.08
33
428
144
1138
1.37
2.52
1.6
1.5
—
—
—
0
0
8
21
3.85
2.47
1.1
1.1
1880.50
1329.24
miu/ml
—
8
21
63
429
1.53
2.45
1.1
1.2
54.89
176.03
iu/ml
5.32
30
180
7
17
4.16
2.36
1.3
1.1
—
—
—
0
0
17
78
2.22
2.33
2.0
1.5
6.31
7.44
mmol/l
1.76
17
66
17
79
2.19
2.27
1.2
1.1
—
—
—
0
0
25
136
1.88
2.21
2.6
1.9
—
—
—
0
0
62
432
1.49
2.18
1.4
1.4
—
—
—
0
0
149
1209
1.32
2.16
1.3
1.3
0.57
1.90
u/ml
1.87
32
328
10
36
2.81
2.14
1.1
1.2
—
—
—
0
0
232
2003
1.28
2.10
6.8
5.3
30.16
29.62
%
0.36
224
1910
158
1299
1.31
2.08
1.8
1.6
—
—
—
0
0
9
31
2.94
2.08
1.1
1.1
—
1.06
—
0
16
128
1024
1.33
2.04
2.5
3.0
7.09
7.84
mmol/l
0.92
120
888
92
1184
0.73
2.02
2.3
2.3
—
—
—
0
0
229
1985
1.27
1.98
6.6
5.2
56.03
56.34
%
0.17
219
1886
98
759
1.36
1.93
2.6
1.9
—
—
—
0
0
145
1193
1.30
1.88
3.0
2.9
11.73
31.97
ng/l
2.87
65
617
107
849
1.33
1.80
2.7
3.8
4.19
12.37
mg/mmol
2.46
66
529
11
47
2.37
1.78
1.5
1.3
0.43
0.45
nmol/l
0.13
11
42
6
18
3.36
1.75
1.8
1.2
—
—
—
0
0
12
54
2.25
1.75
1.4
1.1
—
—
—
0
0
9
36
2.53
1.74
1.0
1.1
—
—
—
0
0
5
13
3.87
1.72
1.0
3.2
150.80
194.00
u/l
—
5
13
8
31
2.60
1.66
1.1
1.9
—
—
—
0
0
7
25
2.82
1.65
1.0
1.0
—
—
—
0
0
77
977
0.75
1.52
3.0
2.6
0.25
0.34
e6/l
0.28
60
707
34
227
1.53
1.50
3.5
6.3
5.71
7.99
mmol/l
3.03
34
219
17
96
1.80
1.40
1.5
1.4
281.63
318.14
ug/g
—
8
53
506
4938
1.62
1.37
22.6
15.3
267.17
259.51
e9/l
1.36
506
4836
21
332
0.62
1.37
1.8
1.7
—
—
—
0
0
5
17
2.96
1.36
1.2
1.2
—
—
—
0
0
87
1069
0.78
1.35
2.1
2.1
—
—
—
0
0
425
4041
1.27
1.35
3.8
3.6
4.73
4.74
mmol/l
0.06
413
3821
14
76
1.87
1.31
1.2
1.2
—
—
—
0
0
57
433
1.35
1.30
2.1
2.1
22.58
24.59
%
0.38
28
376
57
434
1.35
1.29
4.9
3.8
19.84
21.92
%
0.48
13
183
37
263
1.44
1.24
3.6
2.2
66.92
75.85
ml/min/173m2
0.84
13
94
8
37
2.18
1.22
1.1
1.8
—
—
—
0
0
38
517
0.71
1.20
1.4
1.5
—
—
—
0
0
505
4938
1.54
1.19
22.4
15.3
40.37
40.20
%
0.29
416
4684
384
3631
1.21
1.17
3.7
3.8
—
—
—
0
0
8
155
0.51
1.15
1.9
1.5
—
—
—
0
0
0
36
0.00
1.14
0.0
1.4
—
—
—
0
0
20
127
1.60
1.13
1.9
2.6
0.65
0.66
%
0.09
20
127
17
267
0.62
1.11
1.9
2.3
32.64
40.74
u/ml
0.17
17
253
23
336
0.67
1.08
2.7
2.8
—
—
—
0
0
11
59
1.88
1.08
1.1
1.2
—
—
—
0
0
14
223
0.62
0.98
1.6
1.7
3.05
3.31
mg/l
—
9
144
0
30
0.00
0.97
0.0
1.5
—
—
—
0
0
12
70
1.73
0.93
1.2
1.4
—
—
—
0
0
6
30
2.01
0.87
1.0
1.6
—
—
—
0
0
6
114
0.52
0.83
10.5
4.6
1.15
1.31
mg/l
—
6
104
424
4090
1.19
0.83
4.2
3.8
2.82
2.84
mmol/l
0.26
409
3843
12
189
0.63
0.83
1.8
3.6
5.44
5.09
kpa
1.05
12
181
8
46
1.75
0.83
1.4
1.2
—
—
—
0
0
8
46
1.75
0.83
1.1
1.4
—
—
—
0
0
14
90
1.57
0.79
1.2
1.4
—
—
—
0
0
0
26
0.00
0.78
0.0
1.7
—
—
—
0
0
16
109
1.48
0.71
1.4
1.3
—
22.33
—
0
8
7
121
0.57
0.68
1.9
9.4
26.57
24.41
mmol/l
—
7
116
416
4029
1.15
0.66
3.7
3.5
1.45
1.50
mmol/l
1.38
401
3792
19
138
1.39
0.63
1.3
1.2
—
—
—
0
0
15
104
1.46
0.63
1.2
1.0
1.28
1.91
u/ml
—
9
56
24
182
1.33
0.62
1.4
1.7
—
—
—
0
0
8
49
1.64
0.62
1.3
1.8
—
—
—
0
0
0
20
0.00
0.60
0.0
1.9
—
—
—
0
0
0
20
0.00
0.60
0.0
1.9
—
—
—
0
0
0
22
0.00
0.59
0.0
1.4
—
21.84
—
0
22
0
23
0.00
0.58
0.0
1.4
—
—
—
0
0
51
430
1.21
0.58
2.7
2.6
5.86
7.26
umol/l
0.31
41
359
13
89
1.47
0.58
5.7
2.2
9.88
10.51
g/l
0.20
13
83
8
54
1.49
0.57
1.9
1.1
—
—
—
0
0
28
221
1.28
0.56
1.9
1.5
—
—
—
0
0
11
74
1.50
0.53
2.3
2.1
—
—
—
0
0
6
41
1.47
0.50
1.5
1.1
—
—
—
0
0
12
84
1.44
0.49
1.1
1.2
1.33
1.91
u/ml
—
6
32
16
120
1.34
0.46
1.2
1.1
0.91
3.67
u/ml
—
10
63
49
562
0.86
0.43
2.8
2.4
0.48
0.77
e6/l
1.66
33
308
5
31
1.62
0.43
1.0
1.3
—
—
—
0
0
14
181
0.77
0.38
1.6
1.3
—
—
—
0
0
13
98
1.33
0.37
5.7
2.2
2.93
3.48
g/l
1.11
13
93
13
98
1.33
0.37
5.7
2.2
6.38
7.18
g/l
2.38
13
93
9
69
1.31
0.37
1.3
2.2
—
—
—
0
0
6
42
1.43
0.35
1.5
1.1
—
—
—
0
0
6
43
1.40
0.35
1.2
1.2
9.31
13.55
u/l
—
6
38
26
308
0.84
0.35
2.6
2.6
0.72
0.70
ug/l
—
9
183
12
154
0.77
0.32
1.7
1.8
—
—
—
0
0
7
96
0.73
0.31
1.9
1.3
—
—
—
0
0
7
53
1.32
0.31
1.4
1.5
20.77
38.70
nmol/l
—
7
47
94
874
1.09
0.30
3.5
2.5
300.73
4551.85
umol/l
2.69
84
781
16
130
1.24
0.29
1.0
1.2
—
—
—
0
0
16
130
1.24
0.29
1.0
1.2
—
—
—
0
0
7
57
1.23
0.29
1.7
2.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
7
57
1.23
0.29
7.4
4.4
0.44
0.32
u/ml
—
7
31
7
57
1.23
0.29
1.3
1.1
—
—
—
0
0
11
85
1.30
0.28
1.3
1.1
—
—
—
0
0
14
171
0.81
0.26
1.3
1.1
—
—
—
0
0
9
76
1.19
0.24
1.6
1.6
—
—
—
0
0
392
3855
1.07
0.24
3.2
3.2
1.27
1.21
mmol/l
0.76
376
3616
11
88
1.26
0.22
1.7
1.5
—
—
—
0
0
10
79
1.27
0.22
1.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
6.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
18.70
—
0
10
12
98
1.23
0.21
6.1
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
17
198
0.85
0.21
1.4
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
52
1.16
0.19
1.8
1.5
—
—
—
0
0
131
1259
1.05
0.18
3.2
2.8
—
—
—
0
0
7
59
1.19
0.18
1.6
1.8
—
—
—
0
0
29
320
0.90
0.17
1.2
1.0
—
—
—
0
0
11
91
1.21
0.17
6.5
2.3
2.12
2.86
g/l
1.49
11
86
16
141
1.14
0.14
1.6
1.3
—
—
—
0
0
74
714
1.04
0.09
2.3
3.0
339.29
917.52
ng/l
5.26
65
575
11
124
0.88
0.09
1.4
1.3
—
7.37
—
0
21
10
88
1.14
0.08
2.1
2.1
307.26
267.43
ug/l
—
10
82
6
74
0.81
0.07
2.3
3.3
59.00
55.62
%
—
6
74
68
659
1.04
0.07
1.6
1.5
—
—
—
0
0
27
255
1.06
0.07
1.2
1.3
88.14
275.41
miu/ml
—
10
129
8
93
0.86
0.06
1.3
1.2
—
—
—
0
0
59
599
0.98
0.02
1.5
1.6
1.33
1.34
%
0.06
52
552
11
107
1.03
0.00
1.1
1.3
—
—
—
0
0
33
326
1.01
0.00
1.2
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
0.50
—
0
6
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
3.07
—
0
5
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
12.67
—
0
6
0
5
0.00
-0.00
0.0
6.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_BINODISTOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BINODISTOTH | 1.046 [0.84, 1.31] | 0.695 |
| Birth year | 0.997 [0.99, 1.01] | 0.575 |
During the follow-up period (1.1.1998 — 31.12.2019), 105 out of 2492 females with H7_BINODISTOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BINODISTOTH | 1.139 [0.89, 1.45] | 0.291 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 1296 males with H7_BINODISTOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_BINODISTOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.227% |
| 5 | 0.569% | 1.355% |
| 10 | 1.518% | 3.457% |
| 15 | 3.118% | 6.739% |
| 20 | 5.849% | 11.563% |
Relationships between endpoints
↥Index endpoint: H7_BINODISTOTH – Other disorders of binocular vision
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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