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Acute myeloid leukaemia, helper endpoint

HLP_C3_AML

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 9840|9861|986[67]|987[1-4]|989[1567]|9910|9920|993[01]
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

351

4. Check minimum number of events

None

351

5. Include endpoints

None

351

6. Filter based on genotype QC (FinnGen only)

351

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Acute myeloid leukaemia, helper endpoint based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 351 146 205
Unadjusted period prevalence (%) 0.07 0.05 0.09
Median age at first event (years) 65.59 57.96 71.03

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
359
Matched controls
3589
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
+∞
323.0
313
*
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
+∞
295.1
241
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
423.2
291.9
260
22
XW000
NOMESCO Finland
Bone marrow biopsy
103.1
191.0
202
44
WW500
NOMESCO Finland
Blood transfusion
72.5
126.7
142
32
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
72.1
107.9
121
25
A04AA01
ATC
ondansetron; systemic, rectal
43.6
85.7
106
34
L03AA02
ATC
filgrastim; parenteral
+∞
78.0
72
*
127
Kela drug reimbursment
Transplant complication
89.4
76.2
83
12
A05AA02
ATC
ursodeoxycholic acid; oral
105.0
70.1
75
9
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
802.1
69.5
66
*
C95.0
ICD-10 Finland
Acute leukaemia of unspecified cell type
+∞
64.5
60
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
368.0
62.4
61
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
19.3
58.0
91
62
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
8.4
50.0
124
212
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
282.5
49.3
49
*
J05AB11
ATC
valaciclovir; oral
8.0
49.2
126
226
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
15.8
49.1
83
67
R50.9
ICD-10 Finland
Fever, unspecified
7.3
45.9
126
247
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
94.3
45.1
49
6
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.7
44.6
116
209
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
40.4
38
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
19.6
39.8
61
37
JN4BD
NOMESCO Finland
Extensive body CT
11.5
37.5
73
78
J01MA12
ATC
levofloxacin; systemic
5.3
36.7
136
373
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
394.8
36.7
36
*
L04AD01
ATC
ciclosporin; systemic
34.9
35.8
46
15
ZX120
NOMESCO Finland
Intravenous
8.0
35.8
87
137
J02AC03
ATC
voriconazole; systemic
382.5
35.6
35
*
D70.89
ICD-10 Finland
Neutropenic splenomegaly
57.6
35.3
41
8
Z51.5
ICD-10 Finland
Palliative care
17.1
33.0
53
36
WW200
NOMESCO Finland
Immunization
19.2
32.6
50
30
H02AB02
ATC
dexamethasone; systemic
48.4
32.6
39
9
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
12.4
32.4
60
57
ZX112
NOMESCO Finland
Subcutaneous
56.9
30.9
36
7
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
10.9
30.9
61
66
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
23.7
30.9
44
21
WW306
NOMESCO Finland
Transfer of stem cells from foreign registered donator
328.5
30.3
30
*
N02AA05
ATC
oxycodone; systemic
5.8
30.0
95
211
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
29.6
28
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
28.9
29.1
39
15
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.6
29.0
209
1003
D64.9
ICD-10 Finland
Anaemia, unspecified
5.4
28.6
97
232
C61
ICD-10 Finland
Malignant neoplasm of prostate
303.8
28.2
28
*
9891/3-C42.1
ICD-O-3
Acute monocytic leukemia of bone marrow
+∞
27.4
26
*
Y84.8
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
81.3
27.2
30
*
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
+∞
26.4
25
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
29.6
26.3
35
13
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
43.7
26.3
32
8
L01BB02
ATC
mercaptopurine; oral
48.3
26.0
31
7
A41.9
ICD-10 Finland
Sepsis, unspecified
9.6
25.7
54
65
C92.4
ICD-10 Finland
Acute promyelocytic leukaemia [PML]
+∞
25.3
24
*
C92.5
ICD-10 Finland
Acute myelomonocytic leukaemia
+∞
25.3
24
*
M04AA01
ATC
allopurinol; systemic
4.4
25.0
105
310
C95.9
ICD-10 Finland
Leukaemia, unspecified
+∞
24.2
23
*
1DB06
NOMESCO Finland
NA
+∞
24.2
23
*
J02AC04
ATC
posaconazole; systemic
+∞
24.2
23
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
10.9
24.1
47
49
C92.1
ICD-10 Finland
Chronic myeloid leukaemia [CML], BCR/ABL-positive
+∞
23.2
22
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.1
23.2
104
324
2050A
ICD-9 Finland
Myeloid leukaemia, Acute
+∞
22.1
21
*
WW302
NOMESCO Finland
Allogenic transfer of stem cells from relative
+∞
22.1
21
*
A41.1
ICD-10 Finland
Sepsis due to other specified staphylococcus
41.5
22.0
27
7
A04AA02
ATC
granisetron; systemic, transdermal
233.5
21.8
22
*
J02AC01
ATC
fluconazole; systemic
3.1
21.5
159
725
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
10.9
21.2
41
42
9873/3-C42.1
ICD-O-3
Acute myeloid leukemia without maturation of bone marrow
+∞
21.0
20
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
21.0
20
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
222.2
20.8
21
*
A03FA01
ATC
metoclopramide; systemic, rectal
4.7
20.6
76
194
L04AA06
ATC
mycophenolic acid; systemic
22.4
20.3
29
14
B73
ICPC
Leukaemia
+∞
20.0
19
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
36.6
19.1
24
7
C92.9
ICD-10 Finland
Myeloid leukaemia, unspecified
+∞
18.9
18
*
WW409
NOMESCO Finland
Other aferesis
+∞
18.9
18
*
2AX04
NOMESCO Finland
NA
+∞
18.9
18
*
D46.2
ICD-10 Finland
Refractory anaemia with excess of blasts [RAEB]
199.9
18.7
19
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
199.9
18.7
19
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
199.9
18.7
19
*
L03AA13
ATC
pegfilgrastim; parenteral
199.9
18.7
19
*
TGC00
NOMESCO Finland
Bronchial lavation
11.0
18.3
35
35
115
Kela drug reimbursment
Breast cancer
+∞
17.9
17
*
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
+∞
17.9
17
*
J01MA14
ATC
moxifloxacin; systemic
5.0
17.5
59
136
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
17.3
143
678
TPH04
NOMESCO Finland
Cathetrisation of vein
3.4
17.1
97
356
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
177.8
16.6
17
*
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
42.2
16.5
20
5
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
42.2
16.5
20
5
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
31.7
16.3
21
7
116
Kela drug reimbursment
Prostate cancer
+∞
15.7
15
*
1BC07
NOMESCO Finland
NA
+∞
15.7
15
*
ZX121
NOMESCO Finland
Central venous catheter
89.0
15.7
17
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
15.2
136
667
R4110
NOMESCO Finland
Physiotherapy
2.8
14.9
115
513
JN4AD
NOMESCO Finland
Body CT examination
8.1
14.8
33
44
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
+∞
14.7
14
*
J05AB01
ATC
aciclovir; systemic
3.0
14.6
98
400
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
37.7
14.6
18
5
A40.8
ICD-10 Finland
Other streptococcal sepsis
23.4
14.4
20
9
L01XX05
ATC
hydroxycarbamide; oral
15.3
14.3
23
16
D70.82
ICD-10 Finland
Drug-induced neutropenia
55.6
13.9
16
*
C90.0
ICD-10 Finland
Multiple myeloma
+∞
13.6
13
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
+∞
13.6
13
*
9866/3-C42.1
ICD-O-3
Acute promyelocytic leukemia, t(15;17)(q22;q11-12) of bone marrow
+∞
13.6
13
*
C93.0
ICD-10 Finland
Acute monoblastic/monocytic leukaemia
+∞
13.6
13
*
L02AE02
ATC
leuprorelin; implant, parenteral
35.5
13.6
17
5
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
6.8
13.6
34
54
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.3
13.5
52
136
A41.8
ICD-10 Finland
Other specified sepsis
15.8
13.3
21
14
H02AB09
ATC
hydrocortisone; systemic
9.9
12.7
25
27
TPH00
NOMESCO Finland
Phlebotomy
25.4
12.6
17
7
1DB07
NOMESCO Finland
NA
+∞
12.6
12
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
12.6
12
*
9920/3-C42.1
ICD-O-3
Therapy-related myeloid neoplasm of bone marrow
+∞
12.6
12
*
B25.9
ICD-10 Finland
Cytomegaloviral disease, unspecified
134.4
12.5
13
*
L04AA01
ATC
[U] ciclosporin; systemic
15.0
12.4
20
14
N05BA06
ATC
lorazepam; systemic, sublingual
5.4
12.1
36
72
H02AB04
ATC
methylprednisolone; systemic
3.0
11.9
74
284
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.5
11.8
106
508
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
11.5
11
*
9874/3-C42.1
ICD-O-3
Acute myeloid leukemia with maturation of bone marrow
+∞
11.5
11
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
11.5
11
*
WF002
NOMESCO Finland
Radical radiotherapy
123.8
11.5
12
*
L02BA01
ATC
tamoxifen; oral
123.8
11.5
12
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.5
11.4
101
479
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.0
11.3
31
56
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
6.9
11.0
27
42
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
12.5
11.0
19
16
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.1
11.0
43
115
TAB00
NOMESCO Finland
Lumbar puncture
5.7
10.7
30
56
JN4CD
NOMESCO Finland
Very extensive body CT
11.7
10.7
19
17
J01MA02
ATC
ciprofloxacin; systemic
2.2
10.5
148
877
WW304
NOMESCO Finland
Transfer of stem cells from registered domestic donator
+∞
10.5
10
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.6
10.4
88
402
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
19.5
10.3
15
8
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
15.1
10.1
16
11
L02BG04
ATC
letrozole; oral
41.3
10.0
12
*
5BA08
NOMESCO Finland
NA
26.9
9.9
13
5
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
9.4
9
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
9.4
9
*
Y77
ICPC
Malignant neoplasm prostate
+∞
9.4
9
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
9.4
9
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
9.4
9
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
9.4
9
*
9867/3-C42.1
ICD-O-3
Acute myelomonocytic leukemia, NOS, of bone marrow
+∞
9.4
9
*
212
Kela drug reimbursment
Gout
5.9
9.2
25
45
HA1AA
NOMESCO Finland
X-ray mammography
7.1
9.0
21
31
306
Kela drug reimbursment
Erythropoietin and darbepoetin
51.2
8.7
10
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.2
8.7
46
158
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.9
8.6
27
58
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.7
8.5
36
104
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
8.4
8
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
8.4
8
*
A04AD12
ATC
aprepitant; systemic
+∞
8.4
8
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
8.4
8
*
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
+∞
8.4
8
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
8.4
8
*
Z85.6
ICD-10 Finland
Personal history of leukaemia
+∞
8.4
8
*
L02BB03
ATC
bicalutamide; oral
+∞
8.4
8
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
8.3
141
880
GD1AD
NOMESCO Finland
Thorax CT examination
5.3
8.2
24
48
ZX108
NOMESCO Finland
Inhalation
17.7
8.1
12
7
ED1AA
NOMESCO Finland
Mandipular X-ray examination
34.2
8.1
10
*
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
7.5
8.1
18
25
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
8.0
75
361
NK6AN
NOMESCO Finland
Total body bone isotope imaging
46.0
7.7
9
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.4
7.6
36
114
RS220
NOMESCO Finland
NA
10.3
7.6
14
14
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.0
7.4
42
150
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
+∞
7.3
7
*
C50.11
ICD-10 Finland
Malignant tumor of the central part of the mammary gland,ductal tumor
+∞
7.3
7
*
9895/3-C42.1
ICD-O-3
Acute myeloid leukemia with myelodysplasia-related changes of bone marrow
+∞
7.3
7
*
130
Kela drug reimbursment
Malignant tumour
+∞
7.3
7
*
20500
ICD-8 Finland
Myeloid leukaemia, Acute
+∞
7.3
7
*
2AX05
NOMESCO Finland
NA
+∞
7.3
7
*
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
+∞
7.3
7
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
7.3
7
*
D89.89
ICD-10 Finland
Other specified disorders involving the immune mechanism, not elsewhere classified
+∞
7.3
7
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
7.3
7
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
7.2
45
172
A98
ICPC
Health maint/preventive medicine
0.5
7.0
232
2785
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.7
6.9
48
197
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.4
6.8
32
101
SPAT1088
SPAT
Blood transfusion
17.1
6.8
10
6
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
23.0
6.7
9
*
A07AA02
ATC
nystatin; oral
3.3
6.7
32
103
B01AB05
ATC
enoxaparin; parenteral
2.0
6.6
97
565
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
3.2
6.5
33
111
B37.7
ICD-10 Finland
Candidal sepsis
71.0
6.4
7
*
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
71.0
6.4
7
*
N05CF01
ATC
zopiclone; oral
1.9
6.4
124
796
RS221
NOMESCO Finland
NA
8.4
6.4
13
16
B02AA02
ATC
tranexamic acid; systemic
2.5
6.3
49
212
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
18.4
6.3
9
5
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.0
6.3
35
123
C92.7
ICD-10 Finland
Other myeloid leukaemia
+∞
6.3
6
*
D72.9
ICD-10 Finland
Disorder of white blood cells, unspecified
+∞
6.3
6
*
HAB40
NOMESCO Finland
Wedge excision of mammary gland
+∞
6.3
6
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
6.3
6
*
128
Kela drug reimbursment
Cancers of female genital organs
+∞
6.3
6
*
D46.3
ICD-10 Finland
Refractory anemia with excess of blasts with transformation
+∞
6.3
6
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
6.3
6
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
6.3
6
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
6.3
6
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
6.3
6
*
C92.3
ICD-10 Finland
Myeloid sarcoma
+∞
6.3
6
*
C50.99
ICD-10 Finland
Breast, unspecified
+∞
6.3
6
*
1BC01
NOMESCO Finland
NA
+∞
6.3
6
*
2AA01
NOMESCO Finland
NA
+∞
6.3
6
*
D64.8
ICD-10 Finland
Other specified anaemias
6.2
6.1
15
25
B02.9
ICD-10 Finland
Zoster without complication
3.3
6.0
29
94

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
104
24
61.16
180.72
1.3
1.1
—
—
—
0
0
112
38
42.82
176.09
7.0
1.9
—
—
—
0
0
88
18
64.91
156.05
1.3
1.4
—
—
—
0
0
88
20
58.39
152.55
2.8
2.6
—
—
—
0
0
88
35
33.22
130.00
1.5
1.7
101.9
98.6
u/ml
—
24
7
88
37
31.41
127.40
1.3
1.6
—
—
—
0
0
85
40
27.72
117.66
1.4
1.5
243.6
174.8
u/ml
1.28
54
21
95
63
20.30
112.80
1.4
1.4
—
—
—
0
0
71
40
22.00
90.34
1.3
1.0
—
—
—
0
0
115
166
9.82
81.18
9.9
4.6
1.5
0.8
%
1.36
70
38
66
40
20.09
80.92
1.3
1.1
—
—
—
0
0
48
19
29.11
69.78
2.6
1.4
—
—
—
0
0
48
19
29.11
69.78
2.6
1.4
—
—
—
0
0
48
19
29.11
69.78
2.6
1.4
—
—
—
0
0
48
19
29.11
69.78
2.6
1.4
—
—
—
0
0
92
129
9.31
65.64
1.4
1.4
—
—
—
0
0
49
24
23.57
65.63
9.5
3.8
0.8
0.7
%
0.09
43
19
46
20
26.32
64.53
1.6
1.1
—
—
—
0
0
121
235
7.33
64.49
8.8
2.2
60.4
67.4
e9/l
0.79
101
193
92
147
8.13
58.36
10.0
4.9
0.8
0.3
%
1.82
43
29
94
156
7.86
57.59
10.5
4.8
0.2
0.1
%
0.91
66
33
113
229
6.80
57.17
1.6
1.4
—
—
—
0
0
136
346
5.78
53.65
14.5
2.9
0.8
0.8
mmol/l
0.57
129
320
88
151
7.44
51.98
10.0
4.8
7.0
3.0
%
0.50
50
29
78
119
8.14
51.19
1.7
1.7
1.6
1.5
g/l
0.30
67
101
54
6
106.05
50.45
1.4
1.2
—
—
—
0
0
54
6
106.05
50.45
1.0
1.0
—
—
—
0
0
114
262
5.96
49.98
1.6
1.5
—
—
—
0
0
39
21
20.77
49.85
9.3
3.8
—
—
—
0
0
31
10
33.91
47.69
5.1
1.4
25.5
—
%
—
11
0
28
11
27.57
40.28
6.9
1.3
1.2
0.7
e9/l
—
13
5
51
65
9.01
38.50
1.7
1.4
—
—
—
0
0
30
17
19.20
37.23
9.9
2.9
39.7
47.3
%
0.40
22
12
112
326
4.58
35.97
1.7
1.8
—
—
—
0
0
177
762
3.67
31.89
28.4
5.2
—
—
—
0
0
165
680
3.69
31.78
23.4
3.9
—
—
—
0
0
158
670
3.47
28.46
11.0
2.6
315.0
9246.2
umol/l
3.88
152
574
208
1095
3.21
25.26
26.4
5.7
10.5
8.7
%
2.50
202
1009
209
1117
3.15
24.46
25.4
5.5
33.1
27.2
%
6.86
203
1027
205
1090
3.12
24.10
24.7
5.4
1.8
2.9
%
15.50
200
1002
28
6
50.53
23.69
6.5
1.7
—
—
—
0
0
128
533
3.21
22.90
3.2
1.7
4.4
1.2
mg/l
2.44
115
400
26
27
10.32
22.60
1.3
1.1
—
—
—
0
0
112
438
3.29
22.17
1.5
1.3
2.4
2.7
g/l
0.79
98
251
148
705
2.90
20.43
18.1
2.0
—
—
—
0
0
24
5
51.29
20.42
1.3
1.0
—
—
—
0
0
20
17
12.42
19.74
1.4
1.2
—
—
—
0
0
196
1108
2.74
19.08
23.6
5.3
47.0
57.8
%
15.83
190
1021
61
176
3.98
18.98
1.3
1.3
—
—
—
0
0
120
541
2.85
17.98
15.7
2.0
—
—
—
0
0
16
12
13.92
16.90
1.1
1.2
—
—
—
0
0
182
1035
2.58
16.87
24.6
3.5
—
—
—
0
0
21
7
31.77
16.30
8.1
1.4
0.2
0.2
e9/l
—
21
7
212
1317
2.54
15.98
57.1
6.2
2.9
4.3
e9/l
3.05
202
1144
21
28
7.91
14.99
7.1
1.8
33.2
34.4
pg
0.47
21
28
106
488
2.68
14.87
16.8
4.3
—
—
—
0
0
20
9
23.46
14.38
50.9
34.2
154.8
137.9
ug/l
—
20
9
197
1221
2.40
14.38
27.2
5.4
0.1
0.2
e9/l
10.09
179
1074
191
1174
2.38
14.13
22.5
5.1
0.8
0.6
e9/l
0.37
176
1011
191
1181
2.35
13.84
22.5
5.2
0.0
0.0
e9/l
7.23
176
1021
17
5
35.60
13.62
2.2
1.0
—
—
—
0
0
23
38
6.41
13.57
3.1
1.2
—
—
—
0
0
191
1203
2.29
12.97
22.9
5.2
2.0
1.8
e9/l
0.25
179
1059
83
360
2.71
12.92
2.4
1.8
—
—
—
0
0
114
579
2.43
12.76
2.4
1.3
—
—
—
0
0
193
1236
2.25
12.40
21.6
5.5
1.2
1.2
mmol/l
0.23
167
1051
170
1040
2.23
12.16
20.1
3.7
32.4
35.4
g/l
7.92
164
954
179
1128
2.20
11.78
18.7
5.2
1.2
1.2
mmol/l
1.18
172
994
128
717
2.24
11.17
18.6
3.1
7.4
7.4
ph
1.00
22
111
64
262
2.76
11.04
3.3
1.4
—
—
—
0
0
52
194
2.97
10.62
1.9
2.1
0.2
0.2
g/l
0.59
46
170
13
5
26.90
9.88
3.7
1.6
—
—
—
0
0
13
5
26.90
9.88
3.7
1.6
15.8
4.0
%
—
13
5
74
347
2.44
9.60
1.5
2.3
2.0
2.3
g/l
4.01
69
318
70
324
2.45
9.33
1.6
2.4
38.7
23.5
%
4.82
54
285
20
43
4.87
8.94
8.2
3.1
41.6
60.2
%
4.02
20
43
21
48
4.59
8.74
2.6
1.3
3.8
4.0
mmol/l
0.42
21
42
62
286
2.42
8.28
1.9
1.7
—
—
—
0
0
12
17
7.27
8.04
3.2
1.1
—
—
—
0
0
155
1045
1.87
7.40
10.0
10.1
1.2
1.4
inr
0.88
39
287
10
13
7.89
7.15
2.3
1.7
—
—
—
0
0
18
43
4.36
7.10
1.2
1.2
—
—
—
0
0
11
17
6.65
6.81
3.5
1.3
—
—
—
0
0
10
14
7.32
6.73
2.9
1.8
1224.6
715.0
u/ml
—
10
14
197
2443
0.56
6.51
4.7
5.2
2.6
2.6
mmol/l
0.01
184
2216
120
781
1.82
6.19
6.1
2.0
2.3
2.4
mmol/l
2.92
108
626
149
1036
1.76
6.13
4.3
2.6
860.9
127.6
ug/l
3.73
140
948
233
2743
0.55
6.09
88.1
19.5
10.3
6.8
e9/l
0.61
227
2646
233
2742
0.55
6.06
88.2
19.5
3.7
4.5
e12/l
37.34
227
2646
233
2741
0.55
6.03
88.2
19.5
162.0
242.7
e9/l
21.82
227
2652
16
40
4.14
5.96
1.1
1.3
—
—
—
0
0
9
6
15.34
5.93
1.3
1.0
—
—
—
0
0
93
567
1.87
5.87
44.2
4.3
—
—
—
0
0
193
2362
0.59
5.35
4.4
4.6
1.3
1.4
mmol/l
6.26
179
2143
186
2295
0.60
5.29
5.2
6.4
40.1
40.9
mmol/mol
0.64
171
2101
8
6
13.60
5.10
1.0
1.5
—
—
—
0
0
30
124
2.55
5.03
3.6
1.4
3.3
5.2
ug/l
0.32
25
91
198
2392
0.60
4.97
5.6
4.7
6.0
6.1
mmol/l
0.16
182
2137
103
678
1.73
4.95
2.3
2.1
2.7
3.1
mg/l
1.05
83
568
27
110
2.58
4.67
1.5
1.2
—
—
—
0
0
220
2574
0.61
4.56
46.4
12.7
—
—
—
0
0
115
800
1.65
4.43
4.2
3.1
—
—
—
0
0
200
2385
0.62
4.39
5.0
4.6
4.3
4.5
mmol/l
1.12
188
2172
10
22
4.65
4.33
1.8
3.0
—
—
—
0
0
83
533
1.73
4.29
4.8
3.9
96.3
353.5
ng/l
1.27
74
439
36
174
2.19
4.29
9.4
6.6
24.8
24.8
mmol/l
0.01
36
164
8
10
8.15
4.08
5.1
2.4
20.4
13.6
mu/l
—
8
10
227
2614
0.63
4.03
43.6
8.9
29.0
25.0
u/l
3.18
220
2487
191
2277
0.65
3.89
5.5
4.5
1.9
2.0
mu/l
0.04
178
2038
8
11
7.41
3.88
1.1
1.2
—
—
—
0
0
34
169
2.12
3.79
1.6
1.1
—
—
—
0
0
36
183
2.08
3.79
6.4
4.2
—
—
—
0
0
107
763
1.58
3.62
4.2
2.2
48.1
57.9
u/l
2.47
97
703
49
287
1.82
3.44
8.6
6.6
1.3
1.7
mmol/l
0.27
39
221
7
10
7.12
3.38
1.1
1.0
—
—
—
0
0
11
32
3.52
3.36
1.1
1.1
—
—
—
0
0
45
259
1.85
3.34
5.0
4.0
1.4
2.1
mmol/l
0.45
35
204
41
229
1.89
3.34
9.4
6.4
99.5
123.0
g/l
9.39
41
222
48
762
0.57
3.26
4.1
3.1
—
—
—
0
0
41
232
1.87
3.21
2.0
1.8
410.4
365.0
nmol/l
0.88
41
211
196
2281
0.68
3.09
5.4
4.1
1.6
1.3
mmol/l
5.34
183
2055
36
198
1.91
3.07
10.3
8.1
—
—
—
0
0
229
2584
0.67
3.02
57.8
16.4
138.7
139.7
mmol/l
6.18
224
2492
5
5
10.12
2.98
1.8
1.4
—
—
—
0
0
85
600
1.55
2.95
1.9
1.8
1322.4
1166.8
nmol/l
0.69
76
451
6
9
6.76
2.88
1.3
1.0
—
—
—
0
0
6
9
6.76
2.88
1.0
1.1
112.8
121.7
nmol/l
—
6
9
135
1059
1.45
2.78
40.3
7.8
0.0
0.0
e9/l
0.79
113
855
42
252
1.76
2.74
11.7
3.7
—
—
—
0
0
7
14
5.08
2.74
12.6
1.9
—
—
—
0
0
24
119
2.09
2.73
11.4
9.5
—
—
—
0
0
104
779
1.48
2.71
5.4
2.9
63.6
150.3
e6/l
0.50
83
606
98
727
1.48
2.67
2.7
1.6
—
—
—
0
0
7
15
4.74
2.61
1.0
1.2
—
—
—
0
0
6
11
5.53
2.55
1.0
1.1
—
—
—
0
0
7
16
4.44
2.48
1.1
1.1
—
—
—
0
0
28
153
1.90
2.46
1.6
1.5
—
—
—
0
0
29
489
0.56
2.41
1.3
1.2
0.8
1.5
u/ml
—
6
131
94
705
1.46
2.40
5.5
2.9
0.3
0.5
e6/l
0.36
73
525
5
8
6.32
2.38
1.0
1.1
—
—
—
0
0
156
1846
0.72
2.37
5.0
3.7
14.8
14.9
pmol/l
0.31
144
1653
89
663
1.46
2.35
5.6
2.8
—
—
—
0
0
7
18
3.94
2.26
1.3
1.2
—
—
—
0
0
7
18
3.94
2.26
13.0
2.5
—
—
—
0
0
0
61
0.00
2.26
0.0
1.1
—
—
—
0
0
25
138
1.87
2.15
5.7
4.6
—
—
—
0
0
12
49
2.50
2.12
5.8
2.8
—
—
—
0
0
61
836
0.67
2.10
3.0
4.1
5.0
9.1
mg/mmol
1.41
39
537
47
314
1.57
2.07
1.3
1.3
669.1
442.0
titre
0.44
11
79
31
186
1.73
2.05
5.4
4.5
7.4
7.4
ph
—
5
15
17
84
2.08
1.99
1.3
1.2
—
—
—
0
0
5
11
4.59
1.94
1.4
1.3
—
—
—
0
0
5
11
4.59
1.94
1.6
1.3
14.7
11.7
ug/l
—
5
11
5
11
4.59
1.94
2.0
2.3
25.6
26.3
umol/l
—
5
11
189
1639
1.33
1.91
6.6
4.5
320.1
3995.7
e6/l
—
7
29
11
234
0.45
1.87
1.7
1.6
—
—
—
0
0
111
900
1.34
1.75
6.2
3.5
56.7
137.9
e6/l
0.97
86
650
137
1148
1.32
1.71
2.2
2.1
85.6
93.4
pmol/l
1.36
100
575
150
1734
0.76
1.70
6.8
3.9
—
—
—
0
0
64
839
0.71
1.70
2.4
3.2
7.0
7.5
mmol/l
0.37
59
700
60
794
0.71
1.68
2.4
3.3
1150.1
278.3
mg/l
0.37
42
525
13
62
2.14
1.67
1.4
1.1
—
—
—
0
0
198
2202
0.77
1.64
62.1
14.6
33.2
39.8
%
13.32
124
1487
8
175
0.44
1.62
1.4
1.1
—
—
—
0
0
6
21
2.89
1.51
1.0
1.2
—
—
—
0
0
21
124
1.74
1.51
6.6
5.1
25.0
24.8
mmol/l
0.11
21
117
76
947
0.75
1.44
4.5
3.9
2.3
2.1
ug/l
0.29
68
835
230
2492
0.78
1.43
70.0
13.3
36.7
24.2
mg/l
4.92
218
1948
9
40
2.28
1.41
1.1
1.2
—
—
—
0
0
7
29
2.44
1.40
1.1
1.3
—
—
—
0
0
10
48
2.12
1.29
1.3
1.5
—
—
—
0
0
5
118
0.42
1.27
2.8
1.5
—
—
—
0
0
6
25
2.42
1.25
1.7
1.2
1.7
2.8
g/l
—
6
19
6
25
2.42
1.25
1.7
1.2
5.5
6.9
g/l
—
6
19
6
25
2.42
1.25
1.7
1.2
—
—
—
0
0
23
148
1.59
1.23
2.1
2.4
1.3
0.2
e6/l
0.51
23
143
18
111
1.66
1.14
6.5
4.5
—
—
—
0
0
38
508
0.72
1.13
3.0
2.7
0.9
0.8
ug/l
0.18
24
359
14
81
1.76
1.10
2.4
1.7
—
—
—
0
0
11
59
1.89
1.08
2.0
1.7
109.8
135.1
g/l
2.20
11
40
28
195
1.47
1.08
1.7
1.4
—
—
—
0
0
7
33
2.14
1.06
2.1
2.7
—
—
—
0
0
12
67
1.82
1.06
9.0
3.7
—
—
—
0
0
9
46
1.98
1.04
2.8
2.1
—
—
—
0
0
17
108
1.60
0.98
1.1
1.3
—
—
—
0
0
0
31
0.00
0.97
0.0
3.5
—
17.6
—
0
25
8
142
0.55
0.95
6.1
3.5
—
—
—
0
0
12
70
1.74
0.93
8.4
5.8
1.2
1.5
mg/l
1.53
12
63
14
86
1.65
0.92
6.6
4.4
3.5
3.9
mmol/l
2.50
14
79
10
169
0.58
0.91
2.2
2.7
—
—
—
0
0
31
230
1.38
0.88
3.3
3.3
—
—
—
0
0
0
25
0.00
0.79
0.0
1.4
—
—
—
0
0
0
25
0.00
0.79
0.0
1.4
—
—
—
0
0
0
27
0.00
0.77
0.0
1.4
—
—
—
0
0
57
472
1.25
0.77
2.7
2.2
2.4
2.4
mmol/l
0.05
49
391
10
159
0.62
0.74
1.3
1.4
—
—
—
0
0
5
25
2.01
0.73
1.0
1.4
—
—
—
0
0
7
39
1.81
0.73
1.1
1.5
—
—
—
0
0
22
161
1.39
0.70
1.3
1.4
—
—
—
0
0
5
27
1.86
0.68
1.8
1.1
3746.8
1827.5
e6/l
—
5
17
5
91
0.54
0.68
9.4
11.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.6
—
—
—
0
0
0
22
0.00
0.59
0.0
3.3
—
—
—
0
0
6
39
1.55
0.53
1.8
1.2
0.5
0.6
g/l
—
6
33
117
1072
1.14
0.51
3.7
3.8
32.7
72.6
ng/l
0.67
90
768
5
83
0.60
0.46
1.0
1.1
—
—
—
0
0
35
414
0.83
0.45
1.2
1.3
14.0
33.5
iu/ml
2.84
12
142
8
56
1.44
0.43
3.1
1.8
11.1
17.6
u/ml
—
8
42
11
150
0.72
0.42
1.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
5
34
1.48
0.40
1.8
2.6
—
—
—
0
0
0
18
0.00
0.40
0.0
2.1
—
2.5
—
0
13
91
836
1.12
0.38
3.3
2.1
136.4
320.3
u/l
1.15
85
777
33
383
0.85
0.36
1.2
1.3
1.0
12.6
u/ml
—
7
146
23
191
1.22
0.34
3.6
3.3
—
—
—
0
0
36
405
0.88
0.28
20.1
27.8
1.1
1.4
inr
—
7
58
29
253
1.16
0.27
1.5
2.0
103.4
127.8
ug/g
0.40
21
197
61
562
1.10
0.25
3.9
3.9
—
—
—
0
0
65
601
1.10
0.25
1.6
1.8
464.4
11753004.3
pmol/l
0.50
54
485
13
105
1.25
0.25
1.4
1.2
—
—
—
0
0
69
643
1.09
0.23
3.5
4.1
0.0
0.0
estimate
0.00
22
188
5
40
1.25
0.22
1.4
2.3
54.0
64.0
%
—
5
40
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
192
1866
1.06
0.21
5.0
4.1
26.0
12.5
mm/h
10.03
180
1692
0
13
0.00
0.21
0.0
2.6
—
—
—
0
0
100
952
1.07
0.20
3.6
3.7
—
—
—
0
0
6
48
1.25
0.20
1.3
3.3
—
—
—
0
0
12
99
1.22
0.20
1.3
2.6
0.3
0.3
g/l
—
5
34
6
77
0.78
0.15
2.0
1.4
—
—
—
0
0
6
77
0.78
0.15
2.0
1.4
—
—
—
0
0
6
80
0.75
0.15
1.5
1.6
—
—
—
0
0
7
86
0.81
0.14
1.1
1.3
—
0.2
—
0
8
15
134
1.12
0.11
7.3
2.6
1.4
1.2
%
0.59
15
134
15
167
0.89
0.11
1.7
1.3
—
—
—
0
0
5
44
1.14
0.10
4.0
2.2
107.4
105.0
mmol/l
—
5
44
5
44
1.14
0.10
1.2
1.6
—
—
—
0
0
5
44
1.14
0.10
4.0
2.2
—
—
—
0
0
5
44
1.14
0.10
4.0
2.2
3.8
4.1
mmol/l
—
5
44
5
48
1.04
0.09
3.0
1.4
—
—
—
0
0
55
572
0.95
0.09
3.7
4.2
1.0
1.0
kg/l
—
9
86
117
1191
0.97
0.06
5.6
5.2
0.0
0.0
estimate
0.00
22
190
173
1712
1.02
0.05
6.6
4.3
—
—
—
0
0
76
773
0.98
0.03
4.7
3.9
—
—
—
0
0
121
1196
1.02
0.03
3.8
3.8
0.0
0.0
estimate
0.00
24
199
120
1214
0.98
0.03
3.9
3.8
0.0
0.0
estimate
0.00
22
192
15
141
1.07
0.03
2.5
2.5
—
—
—
0
0
64
652
0.98
0.03
3.2
3.3
—
—
—
0
0
21
211
0.99
0.00
1.2
1.3
—
—
—
0
0
32
323
0.99
0.00
1.3
1.2
—
—
—
0
0
7
75
0.93
0.00
1.9
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
30.6
—
0
8
7
76
0.92
0.00
2.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
0.00
2.8
2.3
31.7
33.9
umol/l
—
6
52
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
7.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
0.00
5.5
4.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
3.3
—
0
6
0
6
0.00
0.00
0.0
4.2
—
5.8
—
0
6
0
6
0.00
0.00
0.0
5.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: HLP_C3_AML – Acute myeloid leukaemia, helper endpoint

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).