cardiomyopathy: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
200 |
4. Check minimum number of eventsNone |
200 |
5. Include endpointsNone |
200 |
6. Filter based on genotype QC (FinnGen only) |
197 |
Control definitions (FinnGen only)
- Control exclude
- I9_OTHHEART
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Cardiomyopathy in other diseases
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathy
- Other heart diseases, wide
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1290 | 549 | 728 |
| Only index persons | 1090 | 458 | 632 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 75.24 | 77.02 | 73.83 |
| Only index persons | 75.15 | 76.96 | 73.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 197 | 70 | 127 |
| Unadjusted period prevalence (%) | 0.05 | 0.02 | 0.06 |
| Median age at first event (years) | 73.81 | 71.35 | 75.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 200
- Matched controls
- 2000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I50.9
ICD-10 Finland
Heart failure, unspecified
230.1
229.3
112
11
I43.1*E85.9
ICD-10 Finland
Cardiac amyloidosis
+∞
146.4
122
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
324.5
115.2
107
7
C03DA01
ATC
spironolactone; oral
21.1
98.0
91
76
C03CA01
ATC
furosemide; systemic
20.9
91.6
163
348
B01AF02
ATC
apixaban; oral
36.8
90.2
60
23
207
Kela drug reimbursment
Chronic arrhythmias
+∞
88.2
78
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
88.2
78
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
80.8
72
*
I50.0
ICD-10 Finland
Congestive heart failure
992.8
73.0
67
*
M04AA01
ATC
allopurinol; systemic
12.0
70.3
103
163
I43.8*M10.0
ICD-10 Finland
Gout in the heart
+∞
60.5
55
*
B01AA03
ATC
warfarin; systemic
11.3
59.5
80
111
E85.9
ICD-10 Finland
Amyloidosis, unspecified
+∞
59.4
54
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
10.0
58.5
95
166
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
10.2
55.7
83
130
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
538.7
45.1
43
*
C07AB07
ATC
bisoprolol; oral
8.8
43.8
156
576
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
+∞
39.9
37
*
TFP20
NOMESCO Finland
Cardiodefibrillation
+∞
39.9
37
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
6.8
39.9
93
227
XF404
NOMESCO Finland
Ambulatory ECG
14.4
39.7
39
33
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
460.8
39.5
38
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
12.5
39.5
43
43
E85.4
ICD-10 Finland
Organ-limited amyloidosis
+∞
36.6
34
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.9
34.7
69
142
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
396.8
34.0
33
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
396.8
34.0
33
*
M10.9
ICD-10 Finland
Gout, unspecified
8.8
33.4
48
69
XW000
NOMESCO Finland
Bone marrow biopsy
10.8
32.7
39
44
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
367.3
31.8
31
*
I50.1
ICD-10 Finland
Left ventricular failure
+∞
31.0
29
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.7
30.6
142
599
M10
ICD-10 Finland
Gout
11.5
30.3
34
35
201
Kela drug reimbursment
Chronic cardiac insufficiency
35.7
29.8
38
13
R06.0
ICD-10 Finland
Dyspnoea
5.1
28.4
93
293
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
+∞
27.7
26
*
I48.2
ICD-10 Finland
Chronic atrial fibrillation
+∞
25.6
24
*
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
+∞
24.5
23
*
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
+∞
24.5
23
*
E85.89
ICD-10 Finland
Other amyloidosis
+∞
24.5
23
*
A46
ICD-10 Finland
Erysipelas
5.4
24.1
60
148
C90.0
ICD-10 Finland
Multiple myeloma
35.0
23.6
30
10
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
+∞
23.4
22
*
I43.1
ICD-10 Finland
Cardiomyopathy in metabolic diseases
+∞
23.4
22
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
8.4
23.2
33
46
I50
ICD-10 Finland
Heart failure
135.6
23.1
24
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.6
22.9
74
225
I48.1
ICD-10 Finland
Persistent atrial fibrillation
221.0
19.9
20
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
7.5
19.8
31
48
WX892
NOMESCO Finland
Monitored bed care
7.0
19.7
33
55
I49.5
ICD-10 Finland
Sick sinus syndrome
61.4
19.4
22
*
XF402
NOMESCO Finland
ECG with work load test
5.8
19.2
40
83
I44.2
ICD-10 Finland
Atrioventricular block, complete
+∞
18.0
17
*
A10BK01
ATC
dapagliflozin; oral
6.9
17.9
30
50
C01AA05
ATC
digoxin; systemic
18.5
17.1
26
16
K78
ICPC
Atrial fibrillation/flutter
22.5
16.9
24
12
C09AA05
ATC
ramipril; oral
3.5
16.8
87
357
153
Kela drug reimbursment
Lenalidomid
52.2
16.3
19
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
+∞
15.8
15
*
TFJ02
NOMESCO Finland
Muscle biopsy of heart
+∞
15.8
15
*
M10.0
ICD-10 Finland
Idiopathic gout
12.8
15.3
27
24
N07XX08
ATC
tafamidis; oral
+∞
14.8
14
*
XF400
NOMESCO Finland
ECG with 12 standard connections
3.9
14.8
53
169
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
5.8
14.6
29
57
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
29.8
14.6
19
7
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
5.0
14.5
35
82
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
6.0
14.2
27
51
I35.0
ICD-10 Finland
Aortic (valve) stenosis
57.6
14.0
16
*
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
+∞
13.7
13
*
I42.0
ICD-10 Finland
Dilated cardiomyopathy
+∞
13.7
13
*
3011
Kela drug reimbursment
Tafamidis
+∞
13.7
13
*
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
149.7
13.6
14
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
13.4
45
136
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
20.8
13.2
19
10
L04AX04
ATC
lenalidomide; oral
53.7
13.0
15
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.3
12.9
38
104
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
6.8
12.7
21
34
250, ,
Kela drug reimbursment
+∞
12.6
12
*
I47.2
ICD-10 Finland
Ventricular tachycardia
+∞
12.6
12
*
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
138.3
12.6
13
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
11.1
12.4
23
23
R02
ICPC
Shortness of breath/dyspnoea
4.2
12.1
36
99
B01AF01
ATC
rivaroxaban; oral
4.0
12.1
40
119
329
Kela drug reimbursment
Lenalidomide
49.9
12.0
14
*
A02BC02
ATC
pantoprazole; systemic
3.3
12.0
155
1016
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.2
12.0
36
100
A04AA01
ATC
ondansetron; systemic, rectal
4.3
11.8
33
87
I44.1
ICD-10 Finland
Atrioventricular block, second degree
69.1
11.7
13
*
C01BD01
ATC
amiodarone; systemic
69.1
11.7
13
*
I47.1
ICD-10 Finland
Supraventricular tachycardia
69.1
11.7
13
*
J05AB01
ATC
aciclovir; systemic
3.1
11.6
61
245
N08.4*E85.9
ICD-10 Finland
Glomerular disorders in amyloidosis
+∞
11.6
11
*
GD1LA
NOMESCO Finland
GD
+∞
11.6
11
*
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
10.2
11.3
22
24
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
46.0
11.1
13
*
H02AB06
ATC
prednisolone; systemic
2.7
10.9
113
646
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.5
10.9
43
144
H02AB02
ATC
dexamethasone; systemic
3.5
10.9
44
150
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.7
10.7
39
124
AA1AD
NOMESCO Finland
CT of head and brain
2.8
10.6
74
345
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.9
10.6
25
57
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.3
10.6
46
164
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.7
10.4
97
524
R50.9
ICD-10 Finland
Fever, unspecified
3.4
10.3
43
149
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
10.3
57
234
R60.0
ICD-10 Finland
Localized oedema
3.6
10.1
38
123
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.7
10.1
73
346
R55
ICD-10 Finland
Syncope and collapse
3.6
9.9
37
119
C02AC05
ATC
moxonidine; oral
5.7
9.8
19
36
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.8
9.8
22
31
B01AB05
ATC
enoxaparin; parenteral
2.6
9.7
79
396
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
3.7
9.7
34
105
R07.4
ICD-10 Finland
Chest pain, unspecified
2.7
9.5
69
326
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
104.8
9.5
10
*
AN1
HP
Coronary angiography
3.6
9.5
35
112
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
9.3
73
359
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
9.2
76
382
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
19.7
9.1
13
7
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.8
9.0
30
89
N19
ICD-10 Finland
Unspecified kidney failure
7.8
9.0
20
28
R4110
NOMESCO Finland
Physiotherapy
2.6
9.0
70
342
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
8.3
8.9
19
25
I34.1
ICD-10 Finland
Mitral (valve) prolapse
52.3
8.8
10
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
9.7
8.7
17
19
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.6
8.5
63
299
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
93.8
8.5
9
*
1XX32, ,
NOMESCO Finland
+∞
8.4
8
*
J94.8
ICD-10 Finland
Other specified pleural conditions
12.4
8.2
14
12
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
12.4
8.2
14
12
TPH07
NOMESCO Finland
Cathetrisation of artery
3.4
8.2
32
106
ZXD05
NOMESCO Finland
Urgent procedure
2.5
8.2
67
333
ACC51
NOMESCO Finland
Release of median nerve
3.8
8.1
26
75
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
4.0
8.0
24
66
Z3231
NOMESCO Finland
Registered nurse
2.5
7.9
70
359
M13.9
ICD-10 Finland
Arthritis, unspecified
3.9
7.8
24
67
L01AA03
ATC
melphalan; systemic
46.8
7.8
9
*
SPAT1104
SPAT
Monitoring of emergency patient
4.1
7.6
22
59
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
83.0
7.5
8
*
AP4
HP
Myocardial biopsy
+∞
7.3
7
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.8
7.3
41
168
K77
ICPC
Heart failure
20.9
7.2
10
5
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
20.9
7.2
10
5
K07
ICPC
Swollen ankles/oedema
5.9
7.1
19
35
H02AB07
ATC
prednisone; oral
2.8
6.9
38
153
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
6.5
6.9
17
28
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.2
6.9
19
49
A10BH05
ATC
linagliptin; oral
4.0
6.8
20
54
AA1AA
NOMESCO Finland
Head X-ray examination
17.4
6.8
10
6
SPAT1255
SPAT
Intravenous administration of medicine
3.6
6.8
23
69
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
6.7
83
487
ZXA00
NOMESCO Finland
Right side
2.3
6.6
67
362
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
6.6
39
164
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
4.3
6.5
17
42
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.1
6.5
29
104
ZX112
NOMESCO Finland
Subcutaneous
7.0
6.5
15
23
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
14.9
6.5
10
7
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
72.1
6.5
7
*
Z3226
NOMESCO Finland
Physiotherapist
2.5
6.4
46
212
I10
ICD-10 Finland
Essential (primary) hypertension
2.3
6.4
142
1040
R00.0
ICD-10 Finland
Tachycardia, unspecified
9.7
6.4
12
13
JN3AD
NOMESCO Finland
Abdominal CT examination
2.9
6.3
32
123
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
18.7
6.3
9
5
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.2
6.3
17
43
288
Kela drug reimbursment
Febuxostat
+∞
6.3
6
*
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
+∞
6.3
6
*
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
+∞
6.3
6
*
M04AA03
ATC
febuxostat; oral
+∞
6.3
6
*
I43.8*E05.9
ICD-10 Finland
Thyrotoxic heart disease
+∞
6.3
6
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
8.1
6.2
13
17
N03AX16
ATC
[U] pregabalin
2.3
6.2
54
272
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.7
6.2
20
58
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.6
6.2
41
182
J01MA14
ATC
moxifloxacin; systemic
3.2
6.1
25
85
J01FF01
ATC
clindamycin; systemic
2.3
6.1
59
311
ZXE00
NOMESCO Finland
One hour or less
2.1
6.0
80
478
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
94
46
37.67
132.26
11.9
3.0
37.88
57.89
mg/l
1.06
78
38
93
46
36.92
130.18
12.0
3.0
68.60
33.37
mg/l
2.02
77
39
109
131
17.09
93.75
8.3
2.3
63.45
66.62
g/l
2.70
101
115
147
358
12.72
69.68
11.9
1.9
4933.89
392.85
ng/l
14.28
136
297
59
65
12.46
51.37
8.0
2.2
7.20
7.61
g/l
0.81
54
56
59
65
12.46
51.37
7.9
2.2
3.09
3.61
g/l
2.23
54
56
59
65
12.46
51.37
7.9
2.2
—
—
—
0
0
55
59
12.48
48.62
8.2
2.3
0.93
0.86
g/l
0.04
45
49
56
62
12.16
48.43
8.3
2.2
2.80
3.08
g/l
1.05
51
53
56
62
12.16
48.43
7.9
2.2
8.13
10.75
g/l
3.10
50
52
87
172
8.18
46.83
7.6
4.3
1.13
0.98
mmol/l
4.87
81
159
65
99
9.25
43.82
7.0
4.8
12.46
8.72
mmol/l
2.80
60
94
81
178
6.97
38.52
3.5
1.9
18.80
22.87
%
1.84
71
158
47
58
10.29
37.10
7.9
2.3
36.47
37.76
g/l
0.57
41
49
45
53
10.67
36.75
8.1
2.3
0.01
0.10
g/l
0.40
40
47
81
186
6.64
36.62
3.4
1.9
2.31
2.23
g/l
0.51
75
166
44
52
10.57
35.81
8.3
2.4
0.00
0.00
g/l
-0.00
39
46
83
205
6.21
34.49
3.6
1.9
11.15
12.84
umol/l
1.27
78
185
85
233
5.61
31.02
4.4
3.7
0.81
0.82
mmol/l
0.12
80
212
110
378
5.24
30.52
6.8
2.6
412.85
7142.83
umol/l
1.73
95
311
50
85
7.51
29.90
6.4
1.7
486.78
119.82
ng/l
3.00
50
74
83
237
5.28
28.56
2.5
1.7
—
—
—
0
0
145
664
5.30
27.00
31.8
5.8
1.59
1.10
inr
3.98
31
189
34
14
28.92
25.38
3.1
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
29
31
10.77
25.03
3.8
2.6
0.39
0.40
u/ml
0.04
16
13
142
684
4.71
23.57
14.4
4.7
1.20
1.22
mmol/l
2.77
134
608
121
522
4.34
23.33
4.1
2.2
140.96
185.35
ug/l
1.44
110
468
128
581
4.34
22.84
10.8
2.9
74.96
48.85
ng/l
1.28
113
430
96
356
4.26
22.76
2.6
2.0
3.17
3.00
mg/l
0.24
78
298
50
112
5.62
22.27
3.1
2.0
5.02
4.78
ug/l
0.08
40
94
137
661
4.41
22.23
9.1
4.1
33.18
34.93
g/l
2.50
127
622
154
812
4.90
22.01
17.1
9.0
4.53
4.17
e9/l
1.25
140
711
60
161
4.90
21.62
2.1
1.5
—
—
—
0
0
146
763
4.38
20.54
17.2
5.7
1.20
1.22
mmol/l
3.20
130
649
44
95
5.66
20.30
1.9
1.7
—
—
—
0
0
56
149
4.83
20.28
3.4
3.3
10.33
7.74
umol/l
0.36
47
133
58
162
4.63
19.73
2.1
1.5
—
—
—
0
0
49
120
5.08
19.56
5.1
4.4
2.00
1.85
mmol/l
0.09
41
96
51
130
4.92
19.40
5.6
5.0
0.58
1.49
mmol/l
0.64
42
101
28
15
21.47
19.28
1.6
1.5
23.85
35.93
g/l
2.25
22
15
51
133
4.80
18.83
5.6
4.8
4.70
5.14
kpa
1.95
46
128
77
284
3.78
17.66
2.1
1.9
0.83
1.51
mg/l
3.04
54
229
45
114
4.80
17.12
3.6
2.7
106.54
82.21
ng/l
0.98
39
98
147
838
3.85
16.70
9.6
3.9
6.73
6.86
mmol/l
0.37
140
787
70
251
3.75
16.61
13.5
2.9
294.88
167.79
ng/l
0.27
70
208
40
104
4.56
14.62
2.2
1.4
—
—
—
0
0
93
450
2.99
12.93
4.0
2.0
206.98
186.95
u/l
0.12
84
414
30
71
4.79
12.22
1.4
1.8
1.27
1.66
g/l
1.43
23
61
30
73
4.66
11.81
6.3
5.4
94.13
93.90
%
0.09
30
73
19
14
14.85
11.72
1.3
1.2
2941.00
78510.00
e6/l
—
7
8
48
166
3.49
11.65
10.0
6.0
103.31
103.84
mmol/l
0.26
48
166
29
76
4.29
10.37
6.4
5.2
0.57
0.73
%
1.25
29
76
38
127
3.46
9.63
2.1
2.4
608.19
30.15
u/l
0.49
31
103
20
41
5.31
9.53
1.7
1.3
—
—
—
0
0
29
81
4.02
9.51
5.2
3.2
1.64
1.76
mmol/l
0.07
24
61
13
6
23.02
9.48
1.2
2.0
—
—
—
0
0
28
77
4.07
9.38
6.6
5.2
1.26
1.54
%
0.69
28
77
79
413
2.51
8.73
4.0
3.1
41.21
31.72
u/l
0.86
72
393
22
54
4.45
8.51
1.3
1.1
—
—
—
0
0
18
24
8.13
8.37
1.4
1.3
—
—
—
0
0
18
24
8.13
8.37
1.4
1.3
—
—
—
0
0
67
338
2.48
7.87
3.5
2.8
—
—
—
0
0
18
27
7.21
7.79
1.1
1.2
—
—
—
0
0
93
546
2.31
7.72
4.1
3.2
2.32
2.36
mmol/l
1.06
71
476
99
602
2.28
7.51
4.1
3.4
—
—
—
0
0
148
1075
2.45
7.23
6.7
3.9
21.27
13.54
mm/h
3.37
142
965
15
23
6.96
6.47
2.2
2.0
—
—
—
0
0
21
62
3.67
6.34
2.3
1.6
1.22
7.85
ug/l
0.76
16
53
15
24
6.66
6.30
2.2
1.9
—
—
—
0
0
45
209
2.49
6.17
1.4
1.3
15.32
46.71
iu/ml
2.39
18
65
103
673
2.09
6.15
3.6
2.7
—
—
—
0
0
12
14
9.04
6.15
2.0
2.1
—
—
—
0
0
12
14
9.04
6.15
2.0
2.1
—
—
—
0
0
11
11
10.50
6.11
1.0
1.1
—
—
—
0
0
68
380
2.20
6.09
1.9
1.5
22.71
19.99
nmol/l
0.70
59
317
13
18
7.64
6.03
1.1
1.1
—
—
—
0
0
82
495
2.11
6.01
4.8
3.8
45.97
5.08
mg/mmol
2.32
67
304
15
26
6.15
5.97
1.1
1.5
—
—
—
0
0
17
45
4.04
5.95
2.1
1.3
—
—
—
0
0
12
15
8.43
5.93
1.4
1.0
—
—
—
0
0
10
9
11.61
5.86
3.0
3.7
—
—
—
0
0
77
459
2.10
5.80
4.0
3.3
0.83
0.44
e6/l
0.86
66
351
20
61
3.53
5.76
2.4
1.7
—
—
—
0
0
12
16
7.90
5.72
1.4
3.2
34.42
32.81
pg
0.64
12
16
99
651
2.03
5.68
2.6
2.1
86.69
94.72
pmol/l
0.95
55
329
9
7
13.38
5.63
1.3
1.9
16.67
11.86
u/l
—
9
7
76
456
2.08
5.58
3.3
2.3
56.00
64.60
u/l
0.38
68
420
54
286
2.22
5.45
3.6
3.1
0.98
1.09
e6/l
0.16
34
175
133
986
2.04
5.30
4.5
3.5
15.15
14.96
pmol/l
0.35
115
848
52
274
2.21
5.30
3.7
3.3
2.74
1.10
e6/l
0.81
32
165
173
1425
2.59
5.23
44.4
13.7
25.73
28.16
mg/l
0.47
158
1113
16
36
4.74
5.18
1.5
1.1
—
—
—
0
0
20
66
3.26
5.11
3.3
1.9
—
—
—
0
0
16
46
3.69
5.01
1.3
1.8
—
—
—
0
0
13
24
5.71
5.01
1.2
1.3
—
—
—
0
0
25
99
2.74
4.68
1.3
1.3
—
—
—
0
0
110
795
1.85
4.39
4.3
3.0
81.01
53.85
u/l
1.55
100
721
9
13
7.19
4.21
1.4
1.3
—
—
—
0
0
9
13
7.19
4.21
1.6
1.3
—
—
—
0
0
10
17
6.13
4.18
2.5
2.1
—
—
—
0
0
10
17
6.13
4.18
1.5
1.4
—
—
—
0
0
156
1272
2.03
4.18
5.9
4.2
2.36
2.03
mu/l
1.98
140
1097
94
656
1.82
4.13
3.1
2.5
—
—
—
0
0
7
8
9.01
3.80
1.3
1.5
—
—
—
0
0
7
8
9.01
3.80
1.3
1.5
—
—
—
0
0
46
262
1.98
3.74
1.3
1.2
0.75
1.64
u/ml
—
6
65
6
6
10.25
3.52
1.0
1.7
—
—
—
0
0
7
10
7.21
3.39
2.4
2.3
—
—
—
0
0
7
10
7.21
3.39
2.4
2.3
—
—
—
0
0
31
158
2.14
3.37
5.6
3.4
—
—
—
0
0
56
353
1.81
3.32
1.7
1.7
1106.42
1120.77
nmol/l
0.02
40
260
6
7
8.79
3.28
2.7
2.6
—
—
—
0
0
6
7
8.79
3.28
2.7
2.6
—
—
—
0
0
6
7
8.79
3.28
2.7
2.6
—
—
—
0
0
13
45
3.02
3.09
2.3
1.7
—
—
—
0
0
14
51
2.88
3.05
1.4
2.5
—
—
—
0
0
175
1542
2.08
3.01
52.6
15.3
138.86
139.62
mmol/l
3.46
170
1489
5
5
10.21
2.99
3.0
3.0
—
—
—
0
0
5
5
10.21
2.99
3.0
3.0
—
—
—
0
0
5
5
10.21
2.99
3.0
3.0
—
—
—
0
0
11
32
3.58
2.95
1.5
1.5
—
—
—
0
0
175
1551
2.03
2.82
54.9
15.3
4.03
4.01
mmol/l
0.34
169
1498
11
34
3.36
2.77
1.8
1.4
—
—
—
0
0
5
6
8.50
2.76
3.0
2.8
—
—
—
0
0
5
6
8.50
2.76
3.0
2.8
—
—
—
0
0
82
600
1.62
2.75
2.6
2.1
73.94
78.72
nmol/l
1.01
75
517
36
209
1.88
2.74
1.3
1.3
3.61
17.78
u/ml
—
8
79
51
332
1.72
2.67
3.3
2.9
2.49
2.46
mmol/l
0.38
39
290
7
15
4.79
2.62
1.0
1.1
—
—
—
0
0
5
7
7.29
2.56
1.8
1.6
—
—
—
0
0
5
7
7.29
2.56
1.8
1.6
—
—
—
0
0
5
7
7.29
2.56
1.2
1.0
—
—
—
0
0
156
1348
1.71
2.56
5.0
4.0
1.21
1.26
mmol/l
0.45
140
1182
10
33
3.13
2.39
1.2
1.2
5.80
91.70
e6/l
—
10
27
5
8
6.37
2.38
1.8
1.5
—
—
—
0
0
5
8
6.37
2.38
1.8
1.5
—
—
—
0
0
157
1369
1.68
2.37
7.4
6.3
41.26
40.56
mmol/mol
0.46
146
1236
14
59
2.48
2.35
5.3
4.4
0.77
0.66
%
0.51
14
59
14
60
2.43
2.27
5.4
4.4
1.05
1.30
%
0.59
14
60
5
9
5.66
2.22
1.4
1.4
—
—
—
0
0
8
24
3.43
2.20
1.3
1.4
—
—
—
0
0
12
49
2.54
2.15
1.2
1.2
—
—
—
0
0
12
49
2.54
2.15
1.2
1.2
—
—
—
0
0
5
10
5.10
2.08
1.0
1.0
267.80
319.50
mg/l
—
5
10
22
119
1.95
2.07
1.3
1.5
1.88
1.70
%
0.23
16
102
6
15
4.09
2.05
1.2
1.0
—
—
—
0
0
32
198
1.73
1.99
16.5
6.2
—
—
—
0
0
13
58
2.33
1.95
1.2
1.3
—
—
—
0
0
9
34
2.72
1.89
1.7
1.4
—
—
—
0
0
174
1589
1.73
1.86
60.8
20.2
38.95
39.50
%
0.70
162
1472
174
1589
1.73
1.86
60.5
20.2
4.22
4.43
e12/l
5.00
168
1525
157
1404
1.55
1.77
5.5
4.5
4.11
4.56
mmol/l
6.25
142
1257
156
1394
1.54
1.75
5.6
4.5
1.31
1.45
mmol/l
4.58
141
1236
11
48
2.37
1.74
3.3
4.4
1.36
1.44
mmol/l
0.10
11
48
5
13
3.91
1.72
1.2
1.1
—
—
—
0
0
158
1420
1.54
1.68
6.1
4.8
6.14
6.10
mmol/l
0.17
142
1257
10
41
2.51
1.67
3.2
3.2
3.94
3.89
mmol/l
—
10
41
160
1444
1.54
1.65
6.4
5.1
2.35
2.67
mmol/l
4.39
146
1284
5
14
3.63
1.62
2.0
1.6
—
—
—
0
0
88
714
1.42
1.61
3.9
3.7
0.00
0.00
estimate
-0.00
16
150
12
57
2.18
1.58
1.3
1.1
86.16
136.64
iu/ml
—
5
23
87
710
1.40
1.52
5.3
5.0
0.00
0.00
estimate
-0.00
16
138
9
37
2.50
1.50
1.1
1.2
—
—
—
0
0
5
17
2.99
1.36
1.4
1.4
—
—
—
0
0
152
1377
1.43
1.36
40.0
13.2
63.00
74.78
ml/min/173m2
7.29
138
1132
87
725
1.35
1.29
3.9
3.7
0.00
0.00
estimate
-0.00
13
133
91
768
1.34
1.23
5.3
5.4
2.76
3.10
ug/l
0.23
78
690
29
202
1.51
1.16
5.2
4.8
33.20
32.58
%
0.08
20
120
5
20
2.54
1.16
1.2
1.2
—
—
—
0
0
57
452
1.37
1.14
3.0
3.3
0.73
0.77
ug/l
0.11
38
331
7
33
2.16
1.06
1.6
1.3
—
—
—
0
0
23
156
1.54
1.04
1.3
1.3
—
—
—
0
0
19
128
1.54
0.90
14.3
4.0
1.20
1.23
mmol/l
1.51
19
110
6
33
1.84
0.79
1.7
1.4
—
—
—
0
0
0
25
0.00
0.79
0.0
1.4
—
—
—
0
0
0
28
0.00
0.76
0.0
1.2
—
23.37
—
0
28
72
626
1.23
0.70
4.2
4.8
19.46
21.46
%
0.45
35
352
8
58
1.39
0.42
1.1
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
13
99
1.33
0.36
2.8
3.1
41.17
65.64
ml/min/173m2
—
6
44
9
75
1.21
0.25
1.6
3.1
15.44
3592.54
u/ml
—
9
63
53
570
0.90
0.22
4.8
3.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
5
67
0.74
0.17
2.6
1.8
—
—
—
0
0
10
116
0.85
0.12
1.8
1.4
—
—
—
0
0
36
379
0.94
0.09
1.4
1.8
453.87
18387502.61
pmol/l
0.50
23
310
40
403
0.99
0.00
4.8
3.9
0.00
0.00
estimate
-0.00
12
132
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.5
—
52.67
—
0
6
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMYOINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOINOTH | 2.876 [2.14, 3.87] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.266 |
During the follow-up period (1.1.1998 — 31.12.2019), 309 out of 468 females with I9_CARDMYOINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOINOTH | 3.006 [2.13, 4.25] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 575 males with I9_CARDMYOINOTH died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMYOINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.258% | 0.544% |
| 5 | 1.524% | 3.482% |
| 10 | 4.342% | 8.284% |
| 15 | 8.369% | 15.119% |
| 20 | 14.153% | 24.199% |
Relationships between endpoints
↥Index endpoint: I9_CARDMYOINOTH – Cardiomyopathy in other diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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