cardiomyopathy: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
174 |
4. Check minimum number of eventsNone |
174 |
5. Include endpointsNone |
174 |
6. Filter based on genotype QC (FinnGen only) |
174 |
Control definitions (FinnGen only)
- Control exclude
- I9_OTHHEART
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Cardiomyopathy in other diseases
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathy
- Other heart diseases, wide
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1290 | 549 | 728 |
| Only index persons | 1090 | 458 | 632 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 75.24 | 77.02 | 73.83 |
| Only index persons | 75.15 | 76.96 | 73.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 174 | 65 | 109 |
| Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.05 |
| Median age at first event (years) | 73.17 | 71.37 | 74.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 151
- Matched controls
- 1510
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I43.1*E85.9
ICD-10 Finland
Cardiac amyloidosis
+∞
84.5
73
*
I50.9
ICD-10 Finland
Heart failure, unspecified
238.3
77.5
74
6
I48
ICD-10 Finland
Atrial fibrillation and flutter
125.6
74.4
76
12
C03CA01
ATC
furosemide; systemic
21.7
60.0
118
213
I43.8*M10.0
ICD-10 Finland
Gout in the heart
+∞
54.5
49
*
C03DA01
ATC
spironolactone; oral
28.3
45.7
64
38
E85.9
ICD-10 Finland
Amyloidosis, unspecified
568.9
44.6
42
*
I50.0
ICD-10 Finland
Congestive heart failure
149.0
42.3
43
*
207
Kela drug reimbursment
Chronic arrhythmias
139.5
40.0
41
*
M04AA01
ATC
allopurinol; systemic
14.2
39.1
75
98
B01AA03
ATC
warfarin; systemic
16.3
38.8
68
72
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
234.2
36.5
36
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
35.9
33
*
I43.1
ICD-10 Finland
Cardiomyopathy in metabolic diseases
+∞
33.6
31
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
13.1
32.7
63
78
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
139.6
32.1
33
*
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
+∞
31.3
29
*
TFP20
NOMESCO Finland
Cardiodefibrillation
113.7
26.7
28
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
269.2
23.3
23
*
C07AB07
ATC
bisoprolol; oral
6.0
23.2
107
434
I50.1
ICD-10 Finland
Left ventricular failure
+∞
22.4
21
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
255.5
22.2
22
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
8.5
22.0
53
90
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
+∞
21.3
20
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
6.0
19.7
66
174
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.1
19.6
99
413
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
+∞
18.1
17
*
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
+∞
18.1
17
*
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
+∞
18.1
17
*
I49.5
ICD-10 Finland
Sick sinus syndrome
+∞
18.1
17
*
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
202.8
17.9
18
*
M10
ICD-10 Finland
Gout
16.9
17.7
28
20
E85.89
ICD-10 Finland
Other amyloidosis
+∞
17.0
16
*
I50
ICD-10 Finland
Heart failure
45.6
16.8
20
5
XF404
NOMESCO Finland
Ambulatory ECG
13.5
16.6
29
26
R06.0
ICD-10 Finland
Dyspnoea
4.9
16.6
67
211
B01AF02
ATC
apixaban; oral
17.4
16.0
25
17
A46
ICD-10 Finland
Erysipelas
6.0
15.7
48
109
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.3
15.5
54
143
C90.0
ICD-10 Finland
Multiple myeloma
28.5
15.1
20
8
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
89.0
14.9
16
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
10.3
14.6
29
34
K78
ICPC
Atrial fibrillation/flutter
47.5
14.4
17
*
C09AA05
ATC
ramipril; oral
4.2
13.8
65
230
E85.4
ICD-10 Finland
Organ-limited amyloidosis
+∞
13.7
13
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
153.2
13.7
14
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
14.1
13.1
22
18
M10.9
ICD-10 Finland
Gout, unspecified
8.3
12.9
29
42
C01AA05
ATC
digoxin; systemic
15.0
12.9
21
16
I42.0
ICD-10 Finland
Dilated cardiomyopathy
+∞
12.7
12
*
TFJ02
NOMESCO Finland
Muscle biopsy of heart
+∞
11.6
11
*
C01BD01
ATC
amiodarone; systemic
129.5
11.6
12
*
M10.0
ICD-10 Finland
Idiopathic gout
15.5
11.3
18
13
I35.0
ICD-10 Finland
Aortic (valve) stenosis
47.1
11.1
13
*
A02BC02
ATC
pantoprazole; systemic
3.4
11.0
112
687
XW000
NOMESCO Finland
Bone marrow biopsy
6.9
10.8
27
46
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
+∞
10.5
10
*
XF402
NOMESCO Finland
ECG with work load test
5.5
10.5
32
70
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.3
10.4
42
124
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
11.8
10.1
18
17
N17.9
ICD-10 Finland
Acute renal failure, unspecified
11.2
9.8
18
18
153
Kela drug reimbursment
Lenalidomid
58.9
9.8
11
*
WX892
NOMESCO Finland
Monitored bed care
7.6
9.6
22
33
I44.2
ICD-10 Finland
Atrioventricular block, complete
+∞
9.5
9
*
I48.1
ICD-10 Finland
Persistent atrial fibrillation
+∞
9.5
9
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
+∞
9.5
9
*
I44.1
ICD-10 Finland
Atrioventricular block, second degree
+∞
9.5
9
*
A04AA01
ATC
ondansetron; systemic, rectal
6.4
8.9
23
41
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
6.8
8.9
22
37
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
53.1
8.8
10
*
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
21.6
8.6
12
6
ZXD05
NOMESCO Finland
Urgent procedure
3.1
8.4
55
235
I48.2
ICD-10 Finland
Chronic atrial fibrillation
+∞
8.4
8
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
8.3
67
328
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
8.0
8.2
18
25
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
6.4
8.2
21
37
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
35.4
8.2
10
*
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
14.1
8.0
13
10
XF400
NOMESCO Finland
ECG with 12 standard connections
3.5
8.0
42
151
H02AB06
ATC
prednisolone; systemic
2.7
7.7
82
467
J94.8
ICD-10 Finland
Other specified pleural conditions
26.6
7.7
10
*
N19
ICD-10 Finland
Unspecified kidney failure
8.4
7.6
16
21
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.8
7.6
21
41
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
5.4
7.5
22
46
ZXA00
NOMESCO Finland
Right side
2.9
7.5
57
264
I10
ICD-10 Finland
Essential (primary) hypertension
2.7
7.5
106
707
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
7.4
33
105
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
16.8
7.3
11
7
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
16.8
7.3
11
7
I47.2
ICD-10 Finland
Ventricular tachycardia
+∞
7.3
7
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
+∞
7.3
7
*
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
+∞
7.3
7
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
7.3
43
168
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.0
7.3
29
84
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.4
7.2
26
68
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
21.3
7.2
10
5
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
9.5
7.2
14
16
R07.4
ICD-10 Finland
Chest pain, unspecified
2.9
7.2
51
227
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.6
7.1
73
400
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
7.0
57
275
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.7
7.0
59
291
L04AX04
ATC
lenalidomide; oral
42.0
6.8
8
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
9.4
6.7
13
15
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.3
6.7
36
132
B01AB05
ATC
enoxaparin; parenteral
2.6
6.6
55
269
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
6.5
27
81
I47.1
ICD-10 Finland
Supraventricular tachycardia
72.8
6.5
7
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.5
6.5
31
105
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
3.7
6.4
28
88
R4110
NOMESCO Finland
Physiotherapy
2.7
6.4
51
239
B01AF01
ATC
rivaroxaban; oral
4.3
6.3
23
61
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
28.0
6.3
8
*
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
+∞
6.3
6
*
AP4
HP
Myocardial biopsy
+∞
6.3
6
*
I43.8*E05.9
ICD-10 Finland
Thyrotoxic heart disease
+∞
6.3
6
*
N08.4*E85.9
ICD-10 Finland
Glomerular disorders in amyloidosis
+∞
6.3
6
*
L01AA03
ATC
melphalan; systemic
+∞
6.3
6
*
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
+∞
6.3
6
*
N02AA05
ATC
oxycodone; systemic
3.1
6.2
37
144
AN1
HP
Coronary angiography
3.5
6.1
28
92
K07
ICPC
Swollen ankles/oedema
6.9
6.0
14
22
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
6.0
64
352
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMYOINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOINOTH | 2.876 [2.14, 3.87] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.266 |
During the follow-up period (1.1.1998 — 31.12.2019), 309 out of 468 females with I9_CARDMYOINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOINOTH | 3.006 [2.13, 4.25] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 575 males with I9_CARDMYOINOTH died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMYOINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.258% | 0.544% |
| 5 | 1.524% | 3.482% |
| 10 | 4.342% | 8.284% |
| 15 | 8.369% | 15.119% |
| 20 | 14.153% | 24.199% |
Relationships between endpoints
↥Index endpoint: I9_CARDMYOINOTH – Cardiomyopathy in other diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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