brain aneurysm: A congenital or acquired aneurysm within the cranium.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
351 |
4. Check minimum number of eventsNone |
351 |
5. Include endpointsNone |
351 |
6. Filter based on genotype QC (FinnGen only) |
336 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I67
- Name in latin
- Thrombosis non pyogenes systematis venosi intracranialis
Similar endpoints
↥List of similar endpoints to
Nonpyogenic thrombosis of intracranial venous system
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases, wide definition
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1945 | 1146 | 787 |
| Only index persons | 1787 | 1081 | 706 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 47.77 | 44.15 | 53.10 |
| Only index persons | 47.16 | 43.52 | 52.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 336 | 217 | 119 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.05 |
| Median age at first event (years) | 51.10 | 47.59 | 57.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 351
- Matched controls
- 3510
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I67.6
ICD-10 Finland
Nonpyogenic thrombosis of intracranial venous system
+∞
307.7
349
*
B01AA03
ATC
warfarin; systemic
24.4
215.0
224
237
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
14.4
120.8
134
144
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
25.0
86.7
64
31
AA1AD
NOMESCO Finland
CT of head and brain
7.5
79.0
179
430
N03AX14
ATC
levetiracetam; systemic
19.7
59.4
48
28
R51.80
ICD-10 Finland
Headache
5.7
54.4
143
376
B01AB05
ATC
enoxaparin; parenteral
5.2
52.1
191
659
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
17.2
46.7
40
26
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.7
41.5
94
212
XA800
NOMESCO Finland
Neuropsychological investigation
9.6
39.6
50
60
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
112.5
37.6
40
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
199.9
35.5
36
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
7.7
33.7
51
76
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
39.7
31.3
39
11
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.9
24.6
60
141
K90
ICPC
Stroke/cerebrovascular accident
93.4
24.0
26
*
PA2AD
NOMESCO Finland
CT angiography of brain
69.9
23.2
26
*
K91
ICPC
Cerebrovascular disease
55.9
22.4
26
5
R4120
NOMESCO Finland
Occupational therapy
5.5
22.3
46
93
I63.6
ICD-10 Finland
Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
+∞
22.1
21
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.8
21.9
43
83
K94
ICPC
Phlebitis/thrombophlebitis
22.5
21.7
31
15
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.3
21.6
33
49
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
+∞
21.0
20
*
XF400
NOMESCO Finland
ECG with 12 standard connections
3.6
20.7
83
280
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
18.9
105
429
I69.8
ICD-10 Finland
Sequelae of other and unspecified cerebrovascular diseases
200.3
18.7
19
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.4
18.4
81
288
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.2
17.7
52
140
B01AB04
ATC
dalteparin; parenteral
5.6
17.6
35
68
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
16.8
73
257
K99
ICPC
Cardiovascular disease other
13.7
16.5
28
22
WX892
NOMESCO Finland
Monitored bed care
4.0
15.1
46
127
N03AF02
ATC
oxcarbazepine; oral
5.3
14.3
30
61
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
15.3
14.3
23
16
H47.1
ICD-10 Finland
Papilloedema, unspecified
21.1
13.9
20
10
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.0
13.9
25
44
R4110
NOMESCO Finland
Physiotherapy
2.5
13.7
120
606
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
10.7
13.7
26
26
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
145.4
13.5
14
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
19.2
13.5
20
11
G44.2
ICD-10 Finland
Tension-type headache
2.9
13.5
77
314
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.0
13.5
41
113
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
4.7
13.4
32
73
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
11.6
13.2
24
22
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
9.9
13.2
26
28
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
13.7
13.1
22
17
R4150
NOMESCO Finland
Neuropsychological rehabilitation
33.4
12.7
16
5
ZXD35
NOMESCO Finland
Usual procedure
5.9
12.6
23
41
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.6
12.5
31
73
A02BC02
ATC
pantoprazole; systemic
2.4
12.4
248
1761
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
4.3
12.2
33
83
Z2445
NOMESCO Finland
Psychologist
4.4
12.1
32
79
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
11.1
11.9
22
21
B01AB10
ATC
tinzaparin; parenteral
3.1
11.5
52
185
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
+∞
11.5
11
*
I67.7
ICD-10 Finland
Cerebral arteritis, not elsewhere classified
+∞
11.5
11
*
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
+∞
11.5
11
*
R42
ICD-10 Finland
Dizziness and giddiness
2.5
11.5
85
394
WX872
NOMESCO Finland
Intensive care
4.5
11.2
28
66
K78
ICPC
Atrial fibrillation/flutter
3.9
11.0
33
90
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
+∞
10.5
10
*
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
+∞
10.5
10
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
16.7
10.4
16
10
N03AX18
ATC
lacosamide; systemic
19.5
10.3
15
8
H02AB06
ATC
prednisolone; systemic
2.1
10.2
174
1128
JN4AD
NOMESCO Finland
Body CT examination
3.1
10.1
44
153
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
10.1
160
1008
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.9
10.1
31
86
C10AA05
ATC
atorvastatin; oral
2.1
10.1
128
742
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
10.0
45
160
D68.8
ICD-10 Finland
Other specified coagulation defects
12.7
10.0
17
14
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
102.7
9.5
10
*
G93.2
ICD-10 Finland
Benign intracranial hypertension
102.7
9.5
10
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
11.1
9.4
17
16
Z3231
NOMESCO Finland
Registered nurse
2.1
9.4
112
631
R51
ICD-10 Finland
Headache
3.6
9.3
32
96
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
14.2
9.3
15
11
H02AB09
ATC
hydrocortisone; systemic
5.2
9.2
19
38
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
9.4
9.1
18
20
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.8
9.0
50
199
AA1BD
NOMESCO Finland
Extensive CT of head and brain
7.1
9.0
21
31
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.9
9.0
44
164
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
24.8
9.0
12
5
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.3
8.9
35
114
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
8.9
102
563
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.5
8.3
29
88
WX882
NOMESCO Finland
High dependency care
6.6
8.1
20
32
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
17.7
8.1
12
7
G41.9
ICD-10 Finland
Status epilepticus, unspecified
34.2
8.1
10
*
L04AX01
ATC
azathioprine; systemic
4.0
8.1
23
60
N05CF01
ATC
zopiclone; oral
2.0
8.1
119
718
Z2446
NOMESCO Finland
Social worker
3.0
8.1
36
127
R20.2
ICD-10 Finland
Paraesthesia of skin
3.0
7.9
35
123
TPH07
NOMESCO Finland
Cathetrisation of artery
2.7
7.8
43
171
H02AB02
ATC
dexamethasone; systemic
2.6
7.7
49
209
R4130
NOMESCO Finland
Speech therapy
8.3
7.7
16
20
W19
ICD-10 Finland
Unspecified fall
2.8
7.6
40
155
S01EC01
ATC
acetazolamide; systemic
7.4
7.6
17
24
Z3226
NOMESCO Finland
Physiotherapist
2.2
7.5
75
391
N02AA05
ATC
oxycodone; systemic
2.3
7.5
63
306
XCK00
NOMESCO Finland
Perimetry
3.5
7.4
26
79
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.9
7.4
35
128
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
+∞
7.3
7
*
G41.0
ICD-10 Finland
Grand mal status epilepticus
+∞
7.3
7
*
PAW37
NOMESCO Finland
Biopsy of temporal artery
+∞
7.3
7
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.8
7.3
22
60
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
4.7
7.3
17
38
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
30.7
7.2
9
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.6
7.1
44
185
R50.9
ICD-10 Finland
Fever, unspecified
2.3
7.0
60
293
N03AG01
ATC
valproic acid; systemic, rectal
3.0
6.9
32
115
WX730
NOMESCO Finland
Conventional respirator
14.1
6.9
11
8
N03AB02
ATC
phenytoin; systemic
8.5
6.9
14
17
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.7
6.9
37
145
TAB00
NOMESCO Finland
Lumbar puncture
3.3
6.9
26
83
A04AA02
ATC
granisetron; systemic, transdermal
3.2
6.8
28
94
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.6
6.8
41
170
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
6.8
97
574
RS121, ,
NOMESCO Finland
17.1
6.8
10
6
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.0
6.8
31
111
N05BA01
ATC
diazepam; systemic, rectal
2.3
6.8
53
249
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
23.0
6.7
9
*
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
23.0
6.7
9
*
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.7
6.7
21
59
N03AX16
ATC
[U] pregabalin
2.0
6.7
84
476
UJF32
NOMESCO Finland
Coloscopy
2.0
6.7
84
476
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
12.6
6.6
11
9
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
6.6
45
198
XW000
NOMESCO Finland
Bone marrow biopsy
4.1
6.5
18
46
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.1
6.5
28
97
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
6.4
45
201
N02BE01
ATC
paracetamol; systemic, rectal
2.4
6.4
311
2692
CS494
NOMESCO Finland
Other visual field testing
7.2
6.3
14
20
N29
ICPC
Neurological sympt/complt other
7.2
6.3
14
20
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
+∞
6.3
6
*
I61.6
ICD-10 Finland
Intracerebral haemorrhage, multiple localized
+∞
6.3
6
*
D32.05
ICD-10 Finland
Cerebral meninges
+∞
6.3
6
*
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
6.3
6
*
WX704
NOMESCO Finland
Intubation
2.7
6.2
33
128
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
12.8
6.1
10
8
K93
ICPC
Pulmonary embolism
10.3
6.1
11
11
K29
ICPC
Cardiovascular sympt/complt other
4.0
6.1
17
44
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.0
6.1
17
44
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
6.0
80
460
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
84
33
33.15
124.43
1.1
1.1
—
—
—
0
0
73
31
29.47
104.64
1.4
1.1
2.77
3.00
u/ml
—
39
10
71
31
28.46
100.62
1.4
1.2
2.95
1.33
u/ml
0.70
22
12
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
83
59
18.11
94.45
4.7
3.8
0.47
0.32
u/ml
3.24
67
34
84
73
14.81
85.00
5.2
3.4
184.95
184.88
%
0.00
84
73
55
21
30.87
81.26
2.2
2.0
—
—
—
0
0
143
335
6.52
62.87
6.4
2.3
30.24
29.77
s
0.31
138
325
187
697
4.60
44.68
3.0
1.9
136.31
304.08
u/l
1.04
178
656
236
1094
4.53
40.80
31.4
10.5
1.58
1.18
inr
4.98
78
340
157
630
3.70
31.44
3.8
1.8
2.27
1.19
mg/l
1.01
121
470
35
13
29.71
26.33
1.3
1.2
—
—
—
0
0
112
400
3.64
26.09
5.5
4.4
0.82
0.82
mmol/l
0.06
106
378
256
1567
3.34
23.11
8.4
5.0
6.49
6.52
mmol/l
0.07
248
1437
32
17
20.56
21.71
1.2
1.1
1.04
1.09
ratio
—
9
6
217
1290
2.79
19.14
12.5
7.0
1.21
1.22
mmol/l
0.37
195
1096
82
305
3.20
17.23
9.2
7.1
1.07
1.09
mmol/l
0.18
77
284
197
1162
2.58
16.92
12.4
6.4
1.21
1.22
mmol/l
1.25
184
1060
32
60
5.77
16.69
1.7
1.2
11.87
7.00
e6/l
0.23
23
47
32
60
5.77
16.69
1.8
1.3
8496.43
139.13
e6/l
0.48
23
48
184
1063
2.54
16.34
8.6
5.1
34.74
36.25
g/l
2.61
177
986
93
389
2.89
15.78
2.4
1.9
—
—
—
0
0
71
263
3.13
14.88
2.9
1.9
357.18
358.44
nmol/l
0.02
66
240
216
1386
2.45
14.69
11.3
5.7
27.39
28.97
%
1.20
207
1311
210
1343
2.40
14.21
11.2
5.6
2.58
2.74
%
0.58
203
1263
213
1373
2.40
14.12
10.7
5.5
57.74
56.55
%
0.64
205
1298
216
1401
2.41
14.11
9.7
6.3
10.80
11.80
umol/l
0.61
207
1326
124
633
2.48
13.90
2.6
2.0
3.73
3.01
mg/l
1.03
103
545
69
269
2.95
13.13
2.2
1.8
—
—
—
0
0
23
21
11.63
12.72
1.4
1.1
—
—
—
0
0
77
327
2.74
12.46
3.7
2.5
20.89
24.11
%
1.13
66
286
68
272
2.86
12.31
2.3
1.8
—
—
—
0
0
97
471
2.46
11.87
5.5
3.6
91.41
374.47
ng/l
1.90
64
335
62
248
2.82
11.17
12.9
10.9
0.95
1.37
mmol/l
0.42
49
202
234
1676
2.19
10.69
16.6
8.6
4.21
3.95
e9/l
0.80
210
1477
142
844
2.15
10.56
3.6
2.5
63.06
56.45
u/l
0.27
137
780
18
16
11.79
10.17
2.4
2.2
11.77
12.41
umol/l
0.09
18
16
274
2124
2.32
9.82
5.2
3.8
13.02
10.23
mm/h
2.05
255
1956
156
990
2.04
9.49
2.1
1.9
97.92
94.48
pmol/l
0.37
92
502
19
22
9.06
9.41
2.9
2.2
—
—
—
0
0
189
1293
2.00
9.22
3.9
2.8
102.77
100.39
ug/l
0.06
173
1214
125
739
2.07
9.17
4.6
3.1
0.30
0.34
e6/l
0.18
92
544
37
124
3.22
9.04
1.9
1.6
—
—
—
0
0
174
1165
1.98
8.95
3.0
2.4
75.64
75.54
nmol/l
0.02
152
1049
26
70
3.93
8.79
3.0
1.4
—
—
—
0
0
81
410
2.27
8.77
3.4
3.0
3.36
2.70
e6/l
0.20
42
219
84
433
2.24
8.71
1.5
1.6
1094.70
1223.53
nmol/l
0.65
60
327
150
961
1.98
8.70
4.6
3.1
—
—
—
0
0
18
22
8.56
8.68
1.8
2.2
0.14
0.17
e9/l
0.25
13
17
18
23
8.19
8.47
1.8
2.2
398.62
464.61
e6/l
0.28
13
18
13
9
14.94
8.26
1.6
1.3
—
—
—
0
0
42
162
2.81
8.03
14.3
9.0
23.99
24.94
mmol/l
1.40
42
162
268
2135
2.08
7.83
12.9
6.9
81.96
78.01
u/l
0.47
260
2004
142
923
1.90
7.66
5.1
3.2
2.33
2.35
mmol/l
0.84
119
822
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
13
12
11.20
7.35
1.3
1.2
—
—
—
0
0
81
438
2.10
7.34
3.0
2.9
0.80
0.89
e6/l
0.16
41
246
185
1322
1.84
7.30
3.7
2.6
—
—
—
0
0
98
574
1.98
7.12
1.6
1.5
18.74
21.23
nmol/l
1.19
89
493
18
32
5.87
6.85
1.0
1.0
—
—
—
0
0
142
952
1.83
6.76
4.7
3.1
32.04
30.96
u/l
0.11
136
901
50
229
2.38
6.74
6.9
4.7
1.57
1.88
mmol/l
0.25
44
185
41
171
2.58
6.74
1.8
1.5
—
—
—
0
0
27
90
3.17
6.66
2.3
2.7
—
—
—
0
0
62
314
2.18
6.60
2.8
3.5
8.68
8.41
umol/l
0.02
55
269
141
955
1.80
6.41
3.8
3.2
15.93
34.34
ng/l
3.08
84
583
328
2918
2.89
6.15
26.9
11.9
20.77
21.20
mg/l
0.09
283
2226
11
11
10.28
6.07
1.4
1.2
—
—
—
0
0
40
174
2.47
6.03
8.4
5.4
1.87
1.54
mmol/l
0.21
23
136
103
647
1.84
5.92
3.6
2.2
—
—
—
0
0
35
144
2.59
5.91
1.3
1.4
—
—
—
0
0
15
26
5.98
5.90
1.3
1.1
—
—
—
0
0
15
26
5.98
5.90
1.3
1.1
—
—
—
0
0
17
45
3.92
5.88
3.5
2.9
16.95
16.53
%
—
10
23
329
2946
2.86
5.80
28.7
13.2
139.43
139.64
mmol/l
0.96
323
2865
329
2953
2.82
5.64
29.2
13.3
3.92
3.96
mmol/l
1.79
321
2865
45
213
2.28
5.62
13.1
8.8
1.26
1.39
mmol/l
0.46
45
206
18
52
3.59
5.53
2.9
2.3
127.54
131.59
g/l
0.21
13
37
56
292
2.09
5.51
9.6
7.1
104.61
104.17
mmol/l
0.21
56
292
40
182
2.35
5.47
8.6
5.3
5.00
5.15
kpa
0.64
40
174
20
63
3.31
5.40
1.5
1.2
—
—
—
0
0
46
235
2.10
4.77
5.9
3.9
6.62
37.52
ug/l
0.51
41
184
12
22
5.61
4.64
1.2
1.0
—
—
—
0
0
22
81
2.83
4.60
1.8
1.5
0.01
0.08
iu/ml
—
6
14
103
692
1.69
4.54
4.1
2.5
3235.55
7759.63
umol/l
0.67
89
614
13
28
4.78
4.41
1.7
1.9
—
—
—
0
0
19
67
2.94
4.29
2.7
1.8
—
—
—
0
0
19
69
2.85
4.09
2.7
1.8
—
—
—
0
0
14
36
4.01
4.04
2.6
1.6
—
—
—
0
0
11
22
5.13
4.03
1.4
2.1
402.91
527.55
e6/l
0.48
11
22
9
14
6.56
4.01
1.0
1.0
—
—
—
0
0
237
1987
1.59
3.99
4.0
3.1
41.11
44.55
u/l
0.47
227
1872
32
153
2.20
3.92
3.0
2.4
10448.88
2185.08
u/l
0.71
14
57
11
23
4.90
3.90
1.7
2.1
—
—
—
0
0
71
448
1.73
3.89
4.4
2.7
2.44
2.43
mmol/l
0.29
62
383
15
49
3.15
3.85
2.2
1.8
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
8
12
6.79
3.69
1.3
2.8
233.75
131.83
%
—
8
12
8
13
6.27
3.52
1.3
1.5
—
—
—
0
0
6
6
10.14
3.51
3.8
1.8
—
—
—
0
0
46
265
1.85
3.40
4.1
3.2
—
—
—
0
0
16
59
2.79
3.37
1.5
1.2
—
—
—
0
0
16
59
2.79
3.37
1.5
1.2
—
—
—
0
0
22
96
2.38
3.34
2.0
1.9
—
—
—
0
0
14
48
3.00
3.34
2.3
1.8
—
—
—
0
0
14
48
3.00
3.34
2.3
1.8
—
—
—
0
0
12
33
3.73
3.32
2.8
1.4
—
—
—
0
0
301
2725
1.73
3.26
4.3
3.6
1.41
1.25
mmol/l
2.65
275
2531
14
49
2.93
3.23
2.9
1.7
—
—
—
0
0
8
15
5.43
3.21
1.5
1.4
—
—
—
0
0
8
15
5.43
3.21
1.5
1.4
—
—
—
0
0
12
35
3.51
3.13
2.3
1.7
—
—
—
0
0
12
35
3.51
3.13
2.3
1.7
—
—
—
0
0
79
543
1.59
3.08
1.5
1.7
465.29
437.70
pmol/l
0.33
65
467
6
8
7.60
3.06
1.7
1.6
—
—
—
0
0
33
177
1.95
3.03
1.4
2.2
6.50
8.13
ug/l
0.24
26
158
331
3100
2.19
3.03
17.3
9.2
27.18
26.05
u/l
0.60
321
3004
20
89
2.32
2.92
2.3
1.8
—
—
—
0
0
7
13
5.47
2.88
2.3
1.8
—
—
—
0
0
42
249
1.78
2.85
3.6
2.4
29.71
29.88
u/l
0.01
35
209
8
18
4.52
2.81
1.3
1.1
—
—
—
0
0
5
6
8.43
2.76
1.4
1.3
—
—
—
0
0
5
6
8.43
2.76
1.4
1.2
—
—
—
0
0
5
6
8.43
2.76
1.4
1.3
—
—
—
0
0
5
6
8.43
2.76
1.4
1.2
—
—
—
0
0
5
6
8.43
2.76
1.4
1.3
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
6
10
6.08
2.71
1.0
1.0
126.17
146.10
%
—
6
10
8
19
4.28
2.69
5.6
2.2
—
—
—
0
0
296
2705
1.60
2.64
5.6
4.6
1.68
1.84
mu/l
1.79
275
2499
255
2259
1.47
2.64
4.8
3.9
14.72
14.60
pmol/l
0.35
235
2076
169
1391
1.41
2.63
4.3
3.4
0.00
0.00
estimate
0.50
44
293
7
15
4.74
2.61
2.3
1.7
—
—
—
0
0
22
108
2.11
2.58
2.2
1.6
1.28
1.18
g/l
0.52
22
101
13
50
2.66
2.56
3.5
2.5
1.23
1.40
mmol/l
0.74
13
50
10
31
3.29
2.53
1.2
1.0
—
—
—
0
0
37
220
1.76
2.50
2.8
2.4
—
19.58
—
0
13
17
76
2.30
2.48
1.5
1.4
—
—
—
0
0
21
104
2.08
2.41
2.3
1.6
0.28
0.23
g/l
1.12
21
98
167
1390
1.38
2.36
5.7
4.7
0.00
0.00
estimate
0.50
44
279
32
186
1.79
2.34
4.8
4.3
66.15
69.61
ng/l
0.12
26
168
30
171
1.82
2.33
1.9
1.3
29.71
24.26
iu/l
0.35
25
145
13
53
2.51
2.30
9.1
3.2
4.98
5.01
kpa
0.07
13
53
168
1407
1.37
2.25
4.3
3.4
0.00
0.01
estimate
0.50
43
265
87
652
1.44
2.22
2.4
3.1
1833.09
798.02
ng/l
1.04
71
544
305
2835
1.58
2.21
4.8
4.1
4.66
4.74
mmol/l
0.55
281
2655
6
14
4.34
2.16
2.5
1.8
—
—
—
0
0
10
36
2.83
2.15
2.3
1.7
—
—
—
0
0
16
75
2.19
2.12
2.3
2.7
—
—
—
0
0
17
82
2.13
2.10
1.2
1.1
—
—
—
0
0
9
31
2.95
2.08
1.1
2.1
30.14
27.14
ug/l
—
9
31
8
26
3.12
2.02
1.1
1.2
—
—
—
0
0
8
26
3.12
2.02
1.1
1.2
—
—
—
0
0
95
739
1.39
1.96
1.9
1.7
1.49
1.40
mmol/l
0.43
89
637
11
45
2.49
1.95
1.8
1.5
—
—
—
0
0
8
27
3.01
1.94
5.4
2.4
135.88
44.42
u/ml
—
8
27
8
27
3.01
1.94
1.1
1.2
—
—
—
0
0
8
27
3.01
1.94
1.1
1.2
—
—
—
0
0
8
27
3.01
1.94
1.1
1.2
—
—
—
0
0
302
2819
1.51
1.94
4.8
4.0
1.44
1.49
mmol/l
1.39
275
2635
14
66
2.17
1.84
1.1
1.2
—
—
—
0
0
9
35
2.61
1.81
2.6
1.9
—
—
—
0
0
7
23
3.08
1.81
1.0
5.3
99.43
95.43
%
—
7
23
306
2876
1.50
1.77
5.3
4.4
2.76
2.82
mmol/l
0.59
282
2683
9
36
2.54
1.75
1.1
1.0
—
—
—
0
0
289
2689
1.42
1.75
22.3
10.5
86.72
86.20
ml/min/173m2
0.15
258
2172
279
2581
1.39
1.74
5.8
5.1
38.81
38.92
mmol/mol
0.06
258
2423
5
13
3.88
1.72
1.2
1.3
—
—
—
0
0
89
707
1.35
1.59
1.3
1.3
0.84
0.92
u/ml
0.10
27
188
6
20
3.03
1.58
1.3
1.1
—
—
—
0
0
294
2758
1.41
1.56
4.6
4.1
5.85
5.84
mmol/l
0.03
262
2538
65
493
1.39
1.55
1.2
1.3
10.47
8.88
u/ml
0.08
23
196
5
15
3.37
1.53
1.2
1.0
—
—
—
0
0
5
15
3.37
1.53
2.2
3.1
395.60
706.33
u/ml
—
5
15
5
15
3.37
1.53
1.4
6.9
—
36.40
u/ml
—
0
5
7
27
2.62
1.52
1.0
1.1
—
77.60
—
0
5
6
21
2.89
1.51
3.2
1.6
—
—
—
0
0
67
515
1.37
1.48
1.3
1.3
17.11
26.14
iu/ml
1.05
17
169
10
45
2.26
1.47
2.5
1.8
—
—
—
0
0
22
133
1.70
1.46
2.5
1.8
—
—
—
0
0
30
197
1.57
1.46
2.4
3.5
4.18
4.58
pmol/l
1.07
24
171
5
17
2.97
1.36
1.2
1.2
—
—
—
0
0
5
17
2.97
1.36
1.2
1.2
—
—
—
0
0
13
69
1.92
1.30
1.6
1.5
—
—
—
0
0
8
34
2.38
1.30
2.4
2.6
107.38
105.18
mmol/l
—
8
34
9
44
2.07
1.27
1.8
1.3
—
—
—
0
0
9
44
2.07
1.27
1.8
1.3
—
—
—
0
0
20
123
1.66
1.27
6.5
3.4
1.50
1.22
%
0.30
20
123
9
45
2.03
1.24
1.8
1.3
—
—
—
0
0
9
45
2.03
1.24
1.8
1.3
—
—
—
0
0
9
45
2.03
1.24
1.8
1.3
—
—
—
0
0
9
45
2.03
1.24
1.8
1.3
—
—
—
0
0
10
49
2.07
1.23
1.6
1.4
—
—
—
0
0
13
216
0.59
1.08
1.6
1.5
—
—
—
0
0
29
206
1.44
1.02
4.9
2.5
79.68
70.43
ml/min/173m2
1.20
19
76
10
53
1.91
1.02
8.1
3.1
42.60
32.99
u/ml
—
10
53
36
270
1.37
0.95
1.5
1.9
—
—
—
0
0
15
93
1.64
0.95
1.3
1.3
—
—
—
0
0
6
27
2.24
0.94
2.2
1.7
—
—
—
0
0
40
309
1.33
0.89
4.5
4.0
31.00
32.17
%
0.23
26
208
10
56
1.81
0.88
2.2
1.9
—
—
—
0
0
29
213
1.39
0.88
1.4
1.8
—
—
—
0
0
87
749
1.21
0.81
4.8
3.8
9.26
8.44
mg/mmol
0.06
55
463
12
74
1.64
0.79
1.6
1.4
—
—
—
0
0
5
24
2.10
0.75
1.4
1.5
—
—
—
0
0
5
24
2.10
0.75
2.6
4.5
—
—
—
0
0
123
1102
1.18
0.74
4.8
3.4
—
—
—
0
0
5
28
1.80
0.66
1.0
1.0
—
—
—
0
0
5
28
1.80
0.66
1.2
1.5
—
—
—
0
0
8
131
0.60
0.64
1.4
1.5
—
—
—
0
0
335
3288
1.41
0.63
39.1
17.7
269.10
253.64
e9/l
3.30
326
3220
335
3288
1.41
0.63
39.7
17.8
39.76
40.37
%
1.22
313
3110
8
51
1.58
0.61
7.4
3.3
53.00
57.18
%
—
8
51
84
743
1.17
0.59
5.3
3.6
0.00
0.00
estimate
0.50
42
272
7
113
0.61
0.59
2.0
1.8
—
—
—
0
0
335
3292
1.39
0.58
39.1
17.6
4.45
4.52
e12/l
1.87
326
3216
5
89
0.56
0.56
1.8
1.8
—
—
—
0
0
8
124
0.64
0.55
1.3
1.4
—
—
—
0
0
8
124
0.64
0.55
1.3
1.4
—
—
—
0
0
8
125
0.63
0.55
1.3
1.4
—
—
—
0
0
8
125
0.63
0.55
1.3
1.4
—
—
—
0
0
335
3295
1.37
0.54
39.9
17.8
132.76
135.65
g/l
3.02
330
3257
221
2114
1.12
0.46
3.6
3.5
—
—
—
0
0
64
567
1.16
0.45
1.3
1.5
—
—
—
0
0
60
530
1.16
0.44
4.6
4.2
22.84
22.25
%
0.07
26
240
7
51
1.38
0.44
1.3
1.1
—
—
—
0
0
11
150
0.72
0.42
1.3
1.5
—
—
—
0
0
8
59
1.36
0.41
1.8
1.6
—
—
—
0
0
5
34
1.48
0.40
2.0
1.2
—
—
—
0
0
8
114
0.69
0.37
1.5
1.4
—
—
—
0
0
14
179
0.77
0.36
1.1
1.3
—
—
—
0
0
10
75
1.34
0.30
2.3
1.6
—
—
—
0
0
7
56
1.26
0.29
2.0
1.2
—
—
—
0
0
27
234
1.17
0.27
1.4
1.3
150.33
177.11
iu/ml
—
6
94
5
71
0.70
0.26
1.6
1.3
—
—
—
0
0
72
670
1.09
0.25
4.6
4.6
1.84
2.41
ug/l
0.46
65
600
5
41
1.22
0.22
3.2
2.0
13.10
13.20
%
—
5
41
63
675
0.92
0.22
2.0
1.6
—
—
—
0
0
5
42
1.19
0.21
2.8
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
19.50
—
0
12
42
393
1.08
0.14
3.4
2.8
0.76
0.72
ug/l
0.06
32
248
12
103
1.17
0.14
1.9
1.6
—
—
—
0
0
33
306
1.09
0.13
6.0
6.0
—
—
—
0
0
14
124
1.13
0.11
1.1
1.5
—
—
—
0
0
18
164
1.10
0.10
1.1
1.1
—
—
—
0
0
5
63
0.79
0.08
3.6
2.4
27.60
54.57
ug/min
—
5
37
6
73
0.82
0.07
1.7
1.5
—
—
—
0
0
9
102
0.88
0.06
1.8
1.6
—
—
—
0
0
9
103
0.87
0.06
1.1
1.1
—
—
—
0
0
9
104
0.86
0.06
1.1
1.1
—
—
—
0
0
29
303
0.95
0.05
1.3
1.6
—
—
—
0
0
42
431
0.97
0.03
2.0
2.0
—
—
—
0
0
47
477
0.98
0.01
2.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
58.30
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
7.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
2.24
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint I9_THROMBICV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBICV | 2.151 [1.58, 2.92] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 100 out of 916 females with I9_THROMBICV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBICV | 2.538 [1.86, 3.46] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 119 out of 619 males with I9_THROMBICV died.
Mortality risk
Mortality risk for people of age
years, who have I9_THROMBICV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.224% | 0.476% |
| 5 | 1.437% | 3.118% |
| 10 | 3.209% | 7.444% |
| 15 | 5.841% | 13.79% |
| 20 | 10.125% | 22.083% |
Relationships between endpoints
↥Index endpoint: I9_THROMBICV – Nonpyogenic thrombosis of intracranial venous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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