Inflammatory disorders of male genital organs, not elsewhere classified

N14_INFLAMALEGEN

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only males

226837

2. Check conditions

None

226837

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N49
  • Hospital discharge: ICD-9 6080|6084
  • Hospital discharge: ICD-8 607[4-5]
  • Cause of death: ICD-10 N49
  • Cause of death: ICD-9 6080|6084
  • Cause of death: ICD-8 607[4-5]

2 out of 7 registries used, show all original rules.

497

4. Check minimum number of events

None

497

5. Include endpoints

None

497

6. Filter based on genotype QC (FinnGen only)

497

Control definitions (FinnGen only)

Control exclude
N14_MALEGEN

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N40-N51
Name in latin
Morbositates inflammatoriae organorum genitalium masculinorum non alibi classificatae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4288 - 4288
Only index persons 3668 - 3668
Unadjusted period prevalence (%)
Whole population 0.12 - 0.12
Only index persons 0.14 - 0.14
Median age at first event (years)
Whole population - - 48.29
Only index persons - - 45.88

-FinnGen-

Key figures

All Female Male
Number of individuals 497 - 497
Unadjusted period prevalence (%) 0.22 - 0.22
Median age at first event (years) 54.10 - 54.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
448
Matched controls
4479
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N49.2
ICD-10 Finland
Inflammatory disorders of scrotum
3156.5
204.5
182
*
N49.9
ICD-10 Finland
Inflammatory disorder of unspecified male genital organ
+∞
178.4
159
*
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
45.9
72.9
89
24
N45.9
ICD-10 Finland
Orchitis, epididymitis and epididymo-orchitis without abscess
96.6
60.8
66
8
KFA40
NOMESCO Finland
Incision of scrotum
280.6
50.1
50
*
N40
ICD-10 Finland
Hyperplasia of prostate
6.4
46.8
140
296
6084A
ICD-9 Finland
Other disorders of male genital organs, Other inflammatory disorders of male genital organs
+∞
41.3
39
*
KED22
NOMESCO Finland
Transurethral resection of prostate
27.6
33.0
45
18
J01MA02
ATC
ciprofloxacin; systemic
3.5
32.2
216
947
QBA10
NOMESCO Finland
Incision of skin of trunk
36.4
31.5
40
12
N45.0
ICD-10 Finland
Orchitis, epididymitis and epididymo-orchitis with abscess
+∞
29.5
28
*
60750
ICD-8 Finland
Other disease of male genital organs, Other inflammatory diseases
+∞
28.4
27
*
QBB05
NOMESCO Finland
Revision of wound of skin of trunk
28.6
27.5
37
14
UKC02
NOMESCO Finland
Cystoscopy
4.6
26.2
100
262
XKD00
NOMESCO Finland
Uroflowmetry
4.4
24.8
99
270
KGH10
NOMESCO Finland
Operation for phimosis
49.6
23.6
28
6
N49.1
ICD-10 Finland
Inflammatory disorders of spermatic cord, tunica vaginalis and vas deferens
+∞
23.1
22
*
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
11.8
22.7
42
39
KFD20
NOMESCO Finland
Excision of hydrocele of testis
+∞
22.1
21
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.9
21.6
98
299
N49.0
ICD-10 Finland
Inflammatory disorders of seminal vesicle
+∞
21.0
20
*
N47
ICD-10 Finland
Redundant prepuce, phimosis and paraphimosis
31.8
20.8
27
9
R33
ICD-10 Finland
Retention of urine
5.6
19.9
60
120
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
4.0
18.1
78
225
KFA00
NOMESCO Finland
Exploration of testis
187.1
17.6
18
*
N43.3
ICD-10 Finland
Hydrocele, unspecified
30.2
17.6
23
8
J01MA12
ATC
levofloxacin; systemic
3.0
16.1
102
395
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
4.9
15.9
54
123
G04CA02
ATC
tamsulosin; oral
2.5
15.9
154
770
L73.2
ICD-10 Finland
Hidradenitis suppurativa
34.8
15.9
20
6
J01FF01
ATC
clindamycin; systemic
2.6
15.4
139
667
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
15.3
134
628
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.0
15.1
63
176
N30.0
ICD-10 Finland
Acute cystitis
5.9
14.6
41
75
P01AB01
ATC
metronidazole; oral, rectal
2.4
14.6
152
781
J01EA01
ATC
trimethoprim; systemic
3.9
14.5
63
182
J01DB01
ATC
cefalexin; oral
2.4
14.4
355
2735
KFC00
NOMESCO Finland
Unilateral orchiectomy
20.0
14.4
21
11
N49.8
ICD-10 Finland
Inflammatory disorders of other specified male genital organs
+∞
13.6
13
*
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
6.7
13.5
34
54
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
4.9
13.4
44
97
R31
ICD-10 Finland
Unspecified haematuria
3.6
12.8
59
179
N02BE01
ATC
paracetamol; systemic, rectal
2.3
12.7
355
2794
N43.0
ICD-10 Finland
Encysted hydrocele
+∞
12.6
12
*
A46
ICD-10 Finland
Erysipelas
2.8
12.3
87
357
K60.3
ICD-10 Finland
Anal fistula
8.5
11.7
25
31
XJH00
NOMESCO Finland
Transanal ultrasonography
5.0
11.6
37
79
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.4
11.6
57
183
6000A
ICD-9 Finland
Hyperplasia of prostate[HYPERPLASIA PROSTATAE]
+∞
11.5
11
*
N48.1
ICD-10 Finland
Balanoposthitis
8.7
11.4
24
29
J01CA08
ATC
pivmecillinam; oral
4.7
11.3
38
86
N50.8
ICD-10 Finland
Other specified disorders of male genital organs
36.0
11.3
14
*
S97
ICPC
Chronic ulcer skin
4.5
11.3
40
96
N43.4
ICD-10 Finland
Spermatocele
18.4
10.8
16
9
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.9
10.8
44
121
N02AX02
ATC
tramadol; systemic, rectal
2.0
10.8
197
1265
ZZA00
NOMESCO Finland
Split skin graft
5.5
10.7
31
60
Y05
ICPC
Scrotum/testis sympt/compl other
12.4
10.4
18
15
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
6.5
10.3
26
42
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
10.3
126
684
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.2
10.1
114
595
SPAT1125
SPAT
Stoma care and guidance
11.0
9.9
18
17
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
2.8
9.8
64
248
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
3.0
9.7
56
201
R35
ICD-10 Finland
Polyuria
4.3
9.7
35
86
JHA00
NOMESCO Finland
Anal or perianal incision
7.4
9.6
22
31
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.9
9.5
58
215
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
5.6
9.5
27
51
S10
ICPC
Boil/carbuncle
4.2
9.5
35
88
KFH96
NOMESCO Finland
Other reconstructive operation on testis, epididymis or vas deferens
102.1
9.4
10
*
60740
ICD-8 Finland
Other disease of male genital organs, Seminal vesiculitis
+∞
9.4
9
*
7501
FHL
Testicular exploration (includes removal of biopsy, detorsion or appendix test)
+∞
9.4
9
*
XKD06
NOMESCO Finland
Physiologic investigation of micturition
9.0
9.4
19
22
C03CA01
ATC
furosemide; systemic
2.0
9.3
135
781
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
9.2
191
1261
N03AX16
ATC
pregabalin; oral
2.3
9.2
90
438
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
9.1
100
514
G04CB02
ATC
dutasteride; oral
3.9
9.1
37
102
S18
ICPC
Laceration/cut
1.9
9.0
172
1101
UJF32
NOMESCO Finland
Coloscopy
2.1
8.9
110
594
E0000UV
ATC
NA
2.0
8.8
151
926
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.6
8.7
38
111
N44
ICD-10 Finland
Torsion of testis
28.1
8.5
11
*
7502
FHL
Skrotum's incision revision or suturing
+∞
8.4
8
*
JFF23
NOMESCO Finland
Transversostomy
9.7
8.3
16
17
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.7
8.3
20
31
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.4
8.3
29
70
J01DA01
ATC
[U] cefalexin; systemic
1.8
8.2
255
1901
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
12.0
8.1
14
12
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.3
8.1
39
124
N05BA04
ATC
oxazepam; oral
2.2
8.1
93
486
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
8.0
145
902
B01AB05
ATC
enoxaparin; parenteral
2.0
7.9
113
642
A02BC02
ATC
pantoprazole; systemic
1.8
7.9
247
1837
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
7.8
74
352
JN2BD
NOMESCO Finland
Extensive CT exmaniation of lower part of abdomen
45.8
7.7
9
*
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.5
7.6
63
278
K61.0
ICD-10 Finland
Anal abscess
5.6
7.6
21
39
TQW11
NOMESCO Finland
Vacuum treatment of wound
6.3
7.6
19
31
N41.0
ICD-10 Finland
Acute prostatitis
10.3
7.6
14
14
SPAT1263
SPAT
Sampling
1.8
7.6
157
1021
N30.9
ICD-10 Finland
Cystitis, unspecified
6.2
7.5
19
32
N05AH04
ATC
quetiapine; oral
2.2
7.4
76
374
C07AB07
ATC
bisoprolol; oral
1.8
7.4
196
1375
J01FA06
ATC
roxithromycin; oral
1.8
7.4
149
957
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
7.0
7.4
17
25
M72.6
ICD-10 Finland
Necrotizing fasciitis
+∞
7.3
7
*
M54.5
ICD-10 Finland
Low back pain
1.9
7.3
120
718
J01AA02
ATC
doxycycline; systemic
1.7
7.3
296
2362
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
7.3
77
385
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.1
7.3
39
135
N41.1
ICD-10 Finland
Chronic prostatitis
7.5
7.2
16
22
B03XA02
ATC
darbepoetin alfa; parenteral
6.2
7.1
18
30
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
7.1
119
717
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
7.1
65
305
ZXA05
NOMESCO Finland
Left side
1.9
7.1
107
621
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
5.1
7.1
21
43
WX320
NOMESCO Finland
Spinalanesthesy
2.1
7.0
82
430
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
4.2
7.0
25
62
A28
ICPC
Limited function/disability NOS
2.4
7.0
60
273
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
7.0
57
252
R52.9
ICD-10 Finland
Pain, unspecified
3.1
6.8
35
118
L03.9
ICD-10 Finland
Cellulitis, unspecified
6.0
6.7
17
29
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
3.1
6.7
34
114
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.9
6.6
110
658
XKW99
NOMESCO Finland
Other physiological examination of urinary or male genital system
12.5
6.6
11
9
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
6.3
6.5
16
26
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.6
6.4
27
78
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
6.4
40
151
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.4
6.3
21
49
KED33
NOMESCO Finland
Transurethral incision of prostate
18.3
6.3
9
5
KFD70
NOMESCO Finland
Excision of lesion of skin of scrotum
+∞
6.3
6
*
N48.6
ICD-10 Finland
Induratio penis plastica
+∞
6.3
6
*
QBE05
NOMESCO Finland
Excision of sweat glands or sweat gland bearing skin from trunk
+∞
6.3
6
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.2
6.3
31
102
R53
ICD-10 Finland
Malaise and fatigue
2.1
6.3
73
383
A48.0
ICD-10 Finland
Gas gangrene
27.1
6.2
8
*
7451
FHL
Transurethral adenoma removal
27.1
6.2
8
*
G04CA52
ATC
tamsulosin and dutasteride; systemic
2.5
6.2
47
200
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
6.4
6.2
15
24
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.8
6.2
113
698
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.2
6.2
31
103
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.1
6.2
32
109
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.8
6.1
39
149
SPAT1249
SPAT
Treatment-related counselling outside office
1.7
6.1
144
963
SPAT1254
SPAT
Administration of medicine
2.2
6.1
61
297
N05AX08
ATC
risperidone; systemic
2.7
6.1
40
158
M79.6
ICD-10 Finland
Pain in limb
1.8
6.1
118
743
R39.1
ICD-10 Finland
Other difficulties with micturition
5.3
6.1
17
33
N03AX12
ATC
gabapentin; oral
2.3
6.0
56
264

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
148
534
3.52
33.36
4.6
2.8
—
—
—
0
0
144
541
3.34
30.10
3.6
2.3
—
—
—
0
0
218
1039
2.96
30.09
6.3
4.7
—
—
—
0
0
115
458
2.97
21.04
2.5
1.8
—
—
—
0
0
241
1475
2.23
16.97
6.5
3.9
—
—
—
0
0
305
2066
2.23
16.51
8.0
5.8
7.1
6.9
mmol/l
0.75
292
1957
177
976
2.26
15.86
5.2
2.8
127.4
130.4
e6/l
0.01
142
768
185
1048
2.22
15.44
3.3
2.7
—
—
—
0
0
284
1903
2.15
15.37
6.5
3.2
30.3
2994.1
e6/l
—
6
24
85
354
2.69
13.93
5.2
4.2
2.0
1.6
mmol/l
0.44
71
277
185
1086
2.12
13.80
5.7
3.2
112.2
83.0
e6/l
0.27
145
812
351
2612
2.17
13.73
10.1
8.4
78.2
81.1
u/l
0.73
327
2462
155
866
2.15
13.02
5.0
2.8
—
—
—
0
0
105
503
2.38
12.76
9.7
9.2
103.9
104.4
mmol/l
0.39
99
492
228
1477
2.00
12.74
7.4
5.6
33.7
35.6
g/l
3.54
211
1371
158
896
2.12
12.72
5.2
2.8
0.6
0.5
e6/l
0.01
122
684
124
640
2.25
12.65
4.4
2.6
576.1
595.7
mosm/kgh2o
0.42
112
542
150
836
2.14
12.62
3.6
2.6
—
—
—
0
0
107
523
2.33
12.39
4.0
2.5
1.1
0.4
e6/l
1.04
58
290
262
1794
1.97
12.36
8.0
7.4
13.5
13.0
umol/l
0.14
249
1714
278
1947
1.97
12.23
10.6
10.1
5.0
4.3
e9/l
2.99
248
1701
123
660
2.15
11.26
4.3
2.3
3.2
3.3
e6/l
0.09
115
587
238
1613
1.91
11.23
11.7
8.3
1.2
1.2
mmol/l
0.63
206
1375
105
536
2.22
10.86
3.4
2.8
11.8
13.7
umol/l
1.67
97
505
77
348
2.43
10.54
10.1
11.4
—
—
—
0
0
220
1479
1.87
10.42
10.8
7.7
1.2
1.2
mmol/l
1.15
201
1359
118
641
2.10
10.38
4.1
3.8
0.8
0.8
mmol/l
2.78
111
610
106
555
2.16
10.25
2.2
1.8
—
—
—
0
0
248
1739
1.85
10.21
6.8
6.6
0.2
0.2
e9/l
1.63
221
1536
97
491
2.21
10.20
24.7
24.6
1.3
1.4
inr
0.10
17
67
218
1493
1.82
9.49
12.1
9.5
1.4
1.3
inr
0.69
49
407
97
505
2.14
9.46
3.5
2.7
2.2
2.3
g/l
0.17
91
472
134
787
1.96
9.40
2.6
2.0
3.3
3.0
mg/l
0.51
123
675
92
475
2.15
9.15
3.5
2.8
23.6
24.3
%
0.13
81
426
239
1699
1.78
9.05
6.7
6.2
0.0
0.0
e9/l
0.11
214
1476
244
1747
1.78
9.00
6.5
6.3
1.9
1.9
e9/l
0.01
223
1542
118
676
1.98
8.84
4.2
3.2
1.0
1.0
kg/l
1.27
17
86
164
1048
1.84
8.81
3.6
3.0
61.0
57.9
u/l
0.40
154
988
88
454
2.14
8.75
10.0
10.9
1.3
0.9
mmol/l
0.48
69
349
237
1693
1.76
8.73
6.7
6.2
0.6
0.6
e9/l
0.45
214
1464
283
2137
1.75
8.49
6.0
3.5
—
—
—
0
0
87
456
2.10
8.29
10.0
10.9
11.1
12.1
kpa
1.08
82
438
218
1543
1.74
8.13
7.1
6.2
0.6
0.7
%
0.78
211
1462
23
60
3.97
8.06
2.4
3.4
—
—
—
0
0
105
600
1.95
7.85
1.9
1.7
1192.2
1115.4
nmol/l
0.25
80
475
82
429
2.09
7.83
3.3
2.4
1.9
1.8
%
0.16
75
385
209
1475
1.72
7.79
4.7
2.8
0.0
0.0
estimate
0.00
27
240
222
1595
1.71
7.73
7.6
6.2
2.6
3.0
%
2.64
216
1503
42
165
2.69
7.65
2.4
2.1
4.0
0.9
ug/l
0.74
36
146
228
1655
1.70
7.61
7.7
6.3
25.2
26.6
%
0.93
220
1557
173
1165
1.74
7.58
6.7
6.0
—
—
—
0
0
191
1323
1.72
7.56
2.2
2.0
86.7
90.7
pmol/l
0.67
112
759
210
1495
1.70
7.51
4.7
2.8
0.1
0.0
estimate
0.48
24
233
222
1607
1.69
7.44
8.3
6.6
8.8
9.1
%
0.58
216
1522
224
1628
1.68
7.37
7.3
6.1
58.8
57.7
%
0.60
216
1548
132
829
1.81
7.31
7.1
7.3
—
—
—
0
0
407
3488
1.92
7.29
29.7
14.8
35.6
28.2
mg/l
3.53
363
2766
207
1479
1.68
7.23
6.3
3.8
0.0
0.0
estimate
0.00
29
256
155
1037
1.72
6.83
2.5
2.2
348.0
342.5
u/l
0.01
145
965
17
40
4.37
6.80
2.5
1.8
—
—
—
0
0
73
385
2.05
6.80
2.3
2.6
0.2
0.2
g/l
0.43
65
352
113
692
1.82
6.75
3.9
2.9
—
—
—
0
0
301
2405
1.64
6.53
4.5
3.7
14.5
11.9
mm/h
1.57
282
2222
22
65
3.50
6.49
6.1
3.7
—
—
—
0
0
139
914
1.72
6.48
7.1
4.6
7.4
7.4
ph
0.72
26
156
151
1018
1.69
6.41
3.3
3.1
1693.2
1618.1
ng/l
0.09
138
878
123
788
1.75
6.26
5.0
3.0
0.0
0.0
estimate
0.68
26
224
349
2914
1.66
6.18
4.2
3.5
1.9
2.0
mu/l
0.26
322
2637
57
288
2.11
5.94
1.3
3.2
65.5
66.5
g/l
0.33
47
264
280
2241
1.57
5.69
3.3
2.9
15.0
14.8
pmol/l
0.34
248
2016
164
1164
1.61
5.57
4.6
3.4
7.8
8.8
mmol/l
1.94
136
991
165
1174
1.61
5.54
3.6
2.6
175.3
218.4
ug/l
0.91
153
1079
146
1020
1.61
5.24
4.4
3.6
2.3
2.3
mmol/l
0.19
128
897
29
117
2.57
5.05
5.9
3.1
—
—
—
0
0
185
1381
1.54
4.94
4.5
3.5
58.7
53.1
ng/l
0.10
143
989
107
701
1.67
4.93
4.8
3.8
262.6
602.8
ng/l
1.19
88
577
105
685
1.68
4.91
1.7
1.7
1.7
1.4
mg/l
0.16
82
517
20
67
3.07
4.88
1.4
1.4
124.3
89.6
u/ml
—
6
13
51
268
2.01
4.80
6.8
6.9
—
—
—
0
0
39
187
2.18
4.66
1.6
1.8
1.5
1.5
g/l
0.01
34
164
104
686
1.65
4.65
1.8
1.7
443.2
16525107.8
pmol/l
0.79
86
587
72
429
1.79
4.64
2.0
1.7
—
—
—
0
0
65
377
1.83
4.57
1.2
1.3
200.0
315.2
titre
—
9
66
10
21
4.84
4.55
2.4
1.9
—
—
—
0
0
44
225
2.05
4.46
1.2
2.9
—
—
—
0
0
21
78
2.77
4.30
1.5
1.2
363.3
207.1
u/ml
0.84
13
43
409
3675
1.64
4.25
32.4
17.4
4.0
4.0
mmol/l
0.30
398
3583
69
417
1.76
4.24
2.1
3.0
11.9
10.3
umol/l
0.15
62
375
22
86
2.63
4.11
4.0
3.4
—
—
—
0
0
406
3655
1.61
4.03
32.5
17.3
139.1
139.6
mmol/l
3.91
395
3566
70
432
1.72
3.99
1.9
1.6
—
—
—
0
0
59
349
1.78
3.90
2.3
2.3
6.7
10.3
ug/l
0.89
51
310
144
1063
1.50
3.89
4.4
3.4
83.3
220.7
mg/l
0.85
103
758
147
1090
1.50
3.89
2.4
2.1
—
—
—
0
0
192
1502
1.45
3.87
12.5
9.1
0.0
0.0
e9/l
0.84
150
1226
59
350
1.78
3.86
2.8
2.6
192.5
153.9
ug/g
0.36
50
292
48
267
1.88
3.85
5.1
3.2
—
—
—
0
0
151
1129
1.48
3.83
5.6
4.1
11.1
10.9
mg/mmol
0.02
104
800
41
217
1.97
3.81
15.4
16.7
—
—
—
0
0
32
156
2.12
3.70
2.5
2.6
351.1
606.0
ug/l
0.42
32
151
55
327
1.77
3.58
3.0
2.5
73.8
70.4
e9/l
0.25
35
253
21
87
2.48
3.52
1.2
1.5
—
—
—
0
0
19
75
2.59
3.50
1.4
1.3
—
—
—
0
0
40
218
1.91
3.43
6.3
3.6
1.2
1.2
mmol/l
0.05
35
197
29
141
2.12
3.39
2.6
2.7
—
—
—
0
0
330
2895
1.42
3.29
31.2
17.6
14.2
13.7
%
5.48
324
2812
103
735
1.51
3.23
1.7
1.6
15.1
19.1
nmol/l
3.53
91
627
52
314
1.73
3.22
2.8
3.0
198.9
225.0
ng/l
0.25
45
278
11
33
3.39
3.21
2.5
1.5
9.9
11.4
%
0.73
11
33
27
132
2.11
3.13
5.7
2.5
—
—
—
0
0
19
80
2.43
3.10
1.5
4.5
—
—
—
0
0
379
3425
1.45
3.08
4.9
4.3
6.4
6.1
mmol/l
2.04
352
3120
7
12
5.90
3.03
1.3
1.8
—
—
—
0
0
276
2370
1.37
3.00
4.7
4.1
2.9
2.1
ug/l
0.62
252
2086
18
76
2.42
2.92
5.9
3.4
—
—
—
0
0
417
3853
1.51
2.89
13.9
10.3
29.7
31.7
u/l
1.39
407
3728
55
348
1.65
2.89
2.2
2.6
27.4
181.3
u/l
0.59
48
302
55
348
1.65
2.89
1.6
1.3
—
—
—
0
0
18
77
2.39
2.85
1.2
1.1
—
—
—
0
0
365
3295
1.41
2.83
7.3
5.7
42.2
40.3
mmol/mol
2.32
335
3065
404
3715
1.47
2.82
24.6
13.4
—
—
—
0
0
24
117
2.10
2.82
2.7
2.2
67.5
117.4
ug/min
0.67
19
70
19
84
2.31
2.80
1.3
1.2
—
—
—
0
0
129
988
1.41
2.78
3.7
2.8
395.6
6364.9
umol/l
3.17
113
873
32
175
1.89
2.75
5.0
2.7
—
—
—
0
0
31
168
1.90
2.74
8.3
4.4
—
—
—
0
0
33
183
1.86
2.72
3.1
2.5
—
—
—
0
0
287
2504
1.35
2.69
4.3
3.8
—
—
—
0
0
16
67
2.43
2.66
1.4
1.5
—
—
—
0
0
98
720
1.45
2.64
6.4
4.5
—
—
—
0
0
17
74
2.34
2.60
1.4
1.1
—
—
—
0
0
30
164
1.88
2.59
5.2
2.8
—
—
—
0
0
32
179
1.84
2.58
5.0
2.7
—
—
—
0
0
105
786
1.43
2.56
4.9
2.5
—
—
—
0
0
32
180
1.83
2.54
5.3
2.8
—
—
—
0
0
27
144
1.93
2.51
6.0
3.4
—
—
—
0
0
13
51
2.59
2.46
1.8
1.3
342.0
1806.7
e6/l
—
8
36
23
117
2.01
2.44
1.1
1.3
—
—
—
0
0
23
117
2.01
2.44
1.4
1.2
—
—
—
0
0
43
268
1.66
2.41
4.5
4.0
7.4
7.4
ph
—
7
22
31
176
1.81
2.40
5.0
2.7
—
—
—
0
0
17
78
2.22
2.33
1.2
1.1
—
—
—
0
0
5
9
5.60
2.22
1.6
2.2
5.6
16.0
%
—
5
9
18
87
2.11
2.19
1.9
1.6
260.5
264.2
ug/g
0.03
13
51
28
159
1.81
2.18
1.4
1.2
—
—
—
0
0
29
167
1.78
2.16
2.2
1.8
—
—
—
0
0
36
222
1.67
2.12
2.9
3.0
4.4
4.3
e9/l
0.11
28
173
81
599
1.42
2.11
3.6
3.4
2.5
2.4
mmol/l
0.49
69
524
5
10
5.04
2.07
1.6
2.2
42.6
23.6
%
—
5
10
44
288
1.58
2.06
1.5
1.6
—
—
—
0
0
7
20
3.53
2.06
1.7
4.5
—
—
—
0
0
14
63
2.26
2.02
2.3
3.5
57.7
58.0
%
0.02
14
63
8
26
3.11
2.02
1.0
1.0
—
—
—
0
0
22
119
1.89
2.00
1.7
4.2
60.8
57.7
mg/l
0.06
16
101
22
119
1.89
2.00
1.6
4.2
30.3
37.3
mg/l
0.57
16
102
77
573
1.41
1.94
1.3
1.4
3.8
2.9
g/l
1.21
50
373
6
16
3.78
1.94
1.2
1.1
—
—
—
0
0
80
601
1.39
1.91
1.2
1.2
0.6
1.3
u/ml
3.05
19
162
12
52
2.34
1.89
1.2
1.5
—
—
—
0
0
8
28
2.89
1.87
1.3
1.1
—
—
—
0
0
38
247
1.58
1.85
5.0
3.7
0.5
0.5
%
0.05
12
65
10
40
2.53
1.84
3.4
3.0
—
—
—
0
0
20
108
1.89
1.84
8.4
11.9
1.4
1.4
mmol/l
0.14
15
91
26
421
0.60
1.82
1.5
1.4
—
—
—
0
0
8
29
2.79
1.80
1.0
1.0
—
—
—
0
0
10
41
2.47
1.76
1.9
1.4
—
—
—
0
0
41
275
1.54
1.75
5.4
3.8
0.6
1.0
%
0.61
19
85
426
4049
1.36
1.65
38.3
20.5
243.1
235.9
e9/l
1.27
416
3931
38
255
1.53
1.63
4.6
3.8
0.2
0.2
%
0.16
19
76
5
14
3.60
1.62
2.2
3.1
—
—
—
0
0
426
4052
1.36
1.61
38.0
20.4
30.3
30.6
pg
1.76
420
3983
10
43
2.35
1.61
1.0
1.1
—
—
—
0
0
359
3339
1.27
1.61
28.3
15.5
40.4
41.3
%
1.04
263
2466
426
4053
1.36
1.60
38.0
20.4
90.7
91.0
fl
0.48
420
3985
426
4053
1.36
1.60
38.2
20.5
4.5
4.7
e12/l
5.27
416
3924
426
4054
1.36
1.59
38.4
20.6
135.7
142.0
g/l
9.24
419
3984
426
4054
1.36
1.59
38.3
20.5
7.7
6.8
e9/l
5.74
414
3930
6
20
3.02
1.58
1.3
1.0
—
—
—
0
0
8
33
2.45
1.54
1.0
1.2
—
—
—
0
0
8
33
2.45
1.54
2.0
2.4
—
—
—
0
0
5
15
3.36
1.52
1.4
1.7
—
—
—
0
0
11
51
2.18
1.51
10.7
2.8
—
—
—
0
0
6
21
2.88
1.51
1.2
1.3
—
—
—
0
0
12
58
2.10
1.50
1.2
1.3
—
—
—
0
0
26
163
1.63
1.49
1.1
1.2
—
12.4
—
0
5
9
37
2.46
1.48
1.4
1.6
—
—
—
0
0
5
16
3.15
1.44
17.4
11.3
0.8
0.6
mmol/l
—
5
16
5
16
3.15
1.44
6.0
4.8
—
—
—
0
0
55
410
1.38
1.41
1.6
1.6
—
—
—
0
0
10
46
2.20
1.40
2.0
1.3
9255.8
112748.3
e6/l
—
5
29
20
119
1.71
1.40
1.1
1.2
—
—
—
0
0
15
82
1.86
1.37
5.9
4.0
—
—
—
0
0
9
42
2.16
1.34
1.0
1.3
13.4
6.0
iu/l
—
9
30
380
3587
1.25
1.33
4.8
4.3
4.4
4.5
mmol/l
0.59
347
3345
9
43
2.11
1.31
6.0
4.2
—
—
—
0
0
49
364
1.38
1.29
1.7
1.4
—
—
—
0
0
5
18
2.80
1.29
1.0
1.0
124.2
181.6
iu/ml
—
5
18
19
115
1.68
1.26
2.9
1.5
—
—
—
0
0
9
45
2.02
1.24
1.6
1.2
—
—
—
0
0
12
63
1.93
1.23
2.2
3.3
3.9
4.5
e9/l
0.31
12
63
110
922
1.25
1.23
1.4
1.3
—
—
—
0
0
8
37
2.18
1.22
1.4
1.5
—
—
nmol/l
—
0
0
33
232
1.45
1.18
7.1
2.9
—
—
—
0
0
116
984
1.23
1.16
5.3
3.9
—
—
—
0
0
33
234
1.44
1.14
5.5
3.9
0.0
0.0
%
0.80
11
66
384
3650
1.23
1.14
5.2
4.7
2.7
2.7
mmol/l
0.39
353
3371
376
3567
1.22
1.13
4.8
4.2
1.2
1.3
mmol/l
5.32
346
3289
7
30
2.35
1.12
1.3
1.1
—
—
—
0
0
67
535
1.29
1.11
2.2
2.3
12.0
13.8
nmol/l
1.19
59
479
42
314
1.37
1.09
6.6
4.8
—
—
—
0
0
11
59
1.88
1.08
1.5
2.5
—
—
—
0
0
53
414
1.31
1.04
1.3
1.3
—
—
—
0
0
5
22
2.29
1.03
1.0
1.8
—
—
—
0
0
9
48
1.89
1.01
1.4
1.1
—
—
—
0
0
7
35
2.01
1.00
7.0
3.9
—
—
—
0
0
30
215
1.42
1.00
1.2
1.2
—
—
—
0
0
25
173
1.47
0.99
1.4
1.2
—
30.2
—
0
9
365
3471
1.19
0.98
4.5
3.9
1.5
1.4
mmol/l
2.09
336
3191
19
124
1.55
0.98
1.2
1.2
84.5
121.7
iu/ml
—
6
46
7
36
1.96
0.97
1.0
3.0
—
—
—
0
0
37
278
1.36
0.95
1.3
1.5
—
—
—
0
0
15
93
1.63
0.95
1.9
1.7
—
—
—
0
0
10
55
1.83
0.92
4.1
1.7
—
—
—
0
0
8
43
1.87
0.87
1.4
1.8
33.5
33.3
pg
—
8
43
8
44
1.83
0.86
1.6
1.7
—
—
—
0
0
8
44
1.83
0.86
1.6
1.7
—
—
—
0
0
8
44
1.83
0.86
1.6
1.7
—
—
—
0
0
8
44
1.83
0.86
1.6
1.7
—
—
—
0
0
16
104
1.56
0.85
1.1
1.1
—
—
—
0
0
8
45
1.79
0.84
1.4
1.4
—
—
—
0
0
12
73
1.66
0.82
1.2
1.8
—
—
—
0
0
6
32
1.89
0.82
1.2
1.2
—
—
—
0
0
8
47
1.71
0.81
6.4
4.9
—
—
—
0
0
8
47
1.71
0.81
1.1
1.1
—
—
—
0
0
6
34
1.77
0.76
1.0
1.0
—
—
—
0
0
6
34
1.77
0.76
3.3
2.5
—
—
—
0
0
12
75
1.61
0.75
8.6
4.8
3.8
2.2
mmol/l
—
7
48
9
55
1.65
0.74
1.1
1.3
—
—
—
0
0
18
125
1.46
0.73
3.8
4.6
0.6
0.2
g/l
—
8
77
52
428
1.24
0.72
1.3
1.2
17.0
45.7
iu/ml
2.03
24
131
5
26
1.93
0.71
1.0
1.4
—
—
—
0
0
28
213
1.33
0.70
5.3
3.9
—
—
—
0
0
10
157
0.63
0.70
1.8
1.6
—
—
—
0
0
49
407
1.23
0.64
1.3
1.2
13.2
11.9
u/ml
0.05
19
167
10
63
1.60
0.62
1.0
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
16
115
1.40
0.57
7.8
3.9
—
—
—
0
0
125
1360
0.89
0.50
3.3
2.7
—
—
—
0
0
6
41
1.47
0.50
2.7
2.5
—
—
—
0
0
7
49
1.43
0.46
1.7
1.1
—
—
—
0
0
7
49
1.43
0.46
2.1
1.4
—
—
—
0
0
7
50
1.41
0.45
1.7
1.6
—
—
—
0
0
19
148
1.30
0.44
2.7
2.3
—
—
—
0
0
16
122
1.32
0.43
6.4
3.0
1.9
1.6
mg/l
0.70
16
112
40
342
1.18
0.42
3.6
5.0
22.9
40.5
ug/l
0.29
34
297
5
33
1.52
0.41
1.4
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
3.2
—
0
6
5
35
1.43
0.39
1.0
1.2
—
—
—
0
0
97
891
1.11
0.38
1.7
1.7
1.6
1.5
mmol/l
0.67
83
757
8
115
0.69
0.37
2.1
1.4
—
—
—
0
0
25
298
0.83
0.36
1.6
1.4
—
—
—
0
0
29
246
1.19
0.35
1.2
1.4
—
—
—
0
0
141
1332
1.08
0.31
3.0
2.5
1.0
0.7
ug/l
0.60
87
781
7
54
1.30
0.30
1.7
1.2
—
—
—
0
0
5
39
1.28
0.23
1.4
1.4
473430.0
74771.9
e6/l
—
5
33
5
40
1.25
0.22
2.0
1.6
89.0
87.9
%
—
5
40
18
154
1.18
0.21
1.2
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
8.0
—
0
5
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
0.5
—
0
6
24
212
1.14
0.20
1.6
1.8
45.3
37.5
nmol/l
0.82
24
203
19
165
1.16
0.19
1.1
1.1
—
—
—
0
0
7
61
1.15
0.17
6.0
5.0
236.4
340.5
umol/l
—
7
53
12
101
1.19
0.16
1.0
1.1
—
—
—
0
0
13
113
1.15
0.13
1.2
1.2
—
—
—
0
0
21
230
0.91
0.12
1.5
1.3
—
—
—
0
0
5
45
1.11
0.10
3.6
3.8
2.3
7.0
nmol/l
—
5
45
37
390
0.94
0.09
1.4
1.5
—
—
—
0
0
34
327
1.04
0.05
1.4
1.4
—
—
—
0
0
10
97
1.03
0.00
1.9
2.0
11.9
12.5
mg/l
—
10
91
8
89
0.90
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
0.00
2.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
2.6
—
3240.3
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
1.2
—
0
6
0
6
0.00
0.00
0.0
1.2
—
12.5
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
12
120
1.00
0.00
9.9
11.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint N14_INFLAMALEGEN and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
N14_INFLAMALEGEN 2.512 [2.08, 3.03] < 0.001
Birth year 0.99 [0.98, 1.0] 0.029

During the follow-up period (1.1.1998 — 31.12.2019), 722 out of 2965 males with N14_INFLAMALEGEN died.

Mortality risk

Mortality risk for people of age

years, who have N14_INFLAMALEGEN.

N-year risk Females Males
1 No data 0.608%
5 No data 3.211%
10 No data 7.611%
15 No data 14.331%
20 No data 23.47%

Relationships between endpoints

Index endpoint: N14_INFLAMALEGEN – Inflammatory disorders of male genital organs, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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