preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
437 |
4. Check minimum number of eventsNone |
437 |
5. Include endpointsNone |
437 |
6. Filter based on genotype QC (FinnGen only) |
437 |
Control definitions (FinnGen only)
- Control exclude
- O15_OEDEM_PROTUR_HYPERT
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF3
- Parent code in ICD-10
- O10-O16
- Name in latin
- Hypertensio graviditatis non specificata
Similar endpoints
↥List of similar endpoints to
Unspecified maternal hypertension
based on the number of shared cases.
Similar with more cases:
- Pregnancy hypertension
- Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2797 | 2797 | - |
| Only index persons | 2780 | 2780 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | - |
| Only index persons | 0.10 | 0.10 | - |
| Median age at first event (years) | |||
| Whole population | - | 30.63 | - |
| Only index persons | - | 30.63 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 437 | 437 | - |
| Unadjusted period prevalence (%) | 0.15 | 0.15 | - |
| Median age at first event (years) | 30.97 | 30.97 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 382
- Matched controls
- 3818
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O16
ICD-10 Finland
Unspecified maternal hypertension
+∞
323.0
346
*
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1260.6
169.5
153
*
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
+∞
62.2
58
*
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
+∞
60.0
56
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
5.5
44.0
160
440
WX306
NOMESCO Finland
Lumbar epidural anesthesy
5.6
40.1
138
349
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
+∞
33.8
32
*
6429A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Unspecified hypertension complicating pregnancy, childbirth, or the puerperium[HYPERTENSIO GRAVIDARUM NUD,ENNEN SYNNYTYSTÄ]
+∞
32.8
31
*
C07AG01
ATC
labetalol; systemic
56.5
30.9
36
7
O14.1
ICD-10 Finland
Severe pre-eclampsia
+∞
28.5
27
*
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
3.0
23.4
250
1466
I10
ICD-10 Finland
Essential (primary) hypertension
3.4
21.7
127
486
SPAT1324
SPAT
Screening procedure
2.8
20.3
184
941
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
3.3
18.2
109
414
C09CA01
ATC
losartan; oral
4.0
16.1
70
205
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
2.8
15.8
121
538
205
Kela drug reimbursment
Chronic hypertension
5.4
14.7
45
92
O80.9
ICD-10 Finland
Single spontaneous delivery, unspecified
8.3
14.2
31
40
C08CA05
ATC
nifedipine; systemic
6.4
14.0
37
63
MAC96
NOMESCO Finland
Other induction or advancement of labour
4.6
12.9
45
107
W84
ICPC
Pregnancy high risk
4.0
12.5
51
141
C09AA02
ATC
enalapril; systemic
4.7
12.2
42
98
SPAT1210
SPAT
Application of cast or individual aid
6.5
12.1
31
51
SPAT1357
SPAT
Monitoring of problem during pregnancy
4.2
11.1
43
113
OAA41
SPAT
NA
11.0
10.4
19
18
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
2.9
10.1
65
253
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
4.1
10.1
39
103
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.4
9.5
90
433
6424A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Mild or unspecified pre-eclampsia[PRAE-ECLAMPSIA LEVIS, ENNEN SYNNYTYSTÄ]
+∞
9.4
9
*
C07AB07
ATC
bisoprolol; oral
2.2
9.0
103
543
SPAT1249
SPAT
Treatment-related counselling outside office
1.9
8.7
179
1197
E66.9
ICD-10 Finland
Obesity, unspecified
4.4
8.6
30
72
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
13.2
8.4
14
11
C07AB02
ATC
metoprolol; systemic
2.9
7.9
47
174
WX234
NOMESCO Finland
Paracervical blockade
3.5
7.9
36
110
SPAT1316
SPAT
Extensive health check-up of children and adolescents
3.5
7.7
35
107
O12.0
ICD-10 Finland
Gestational oedema
81.6
7.4
8
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
6.5
7.3
18
29
6423A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Transient hypertension of pregnancy[HYPERTENSIO GRAVIDARUM, ENNEN SYNNYTYSTÄ]
+∞
7.3
7
*
O10.9
ICD-10 Finland
Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium
+∞
7.3
7
*
O12.1
ICD-10 Finland
Gestational proteinuria
+∞
7.3
7
*
K85
ICPC
Elevated blood pressure
3.5
7.2
32
97
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
2.6
7.1
54
230
C08CA01
ATC
amlodipine; oral
2.5
7.0
54
233
-
ICD-10 Finland
NA
7.8
7.0
15
20
SPAT1379
SPAT
Health check-up of pregnant person
2.0
6.9
98
560
Z32.1
ICD-10 Finland
Pregnancy confirmed
2.0
6.8
92
516
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.4
6.5
58
269
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
3.6
6.4
27
79
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
2.1
6.2
79
428
SPAT1301
SPAT
No procedures
1.9
6.1
111
690
SPAT1263
SPAT
Sampling
1.7
6.1
169
1200
SPAT1312
SPAT
General health counselling
1.8
6.1
132
870
Z39.2
ICD-10 Finland
Routine postpartum follow-up
1.8
6.1
115
724
O99.80
ICD-10 Finland
The fear of childbirth
2.3
6.1
54
252
SPAT1380
SPAT
Postpartum check-up
2.0
6.0
85
484
Mortality – FinRegistry
↥Association
Association between endpoint O15_MATERN_HYPERT_UNS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have O15_MATERN_HYPERT_UNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: O15_MATERN_HYPERT_UNS – Unspecified maternal hypertension
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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