cryptorchidism: The failure of one or both testes of a male fetus to descend from the abdomen into the scrotum during the late part of pregnancy. If not surgically corrected in early childhood, males may be at increased risk for testicular cancer later in life.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly males |
226837 |
2. Check conditionsNone |
226837 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
400 |
4. Check minimum number of eventsNone |
400 |
5. Include endpointsNone |
400 |
6. Filter based on genotype QC (FinnGen only) |
400 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_GENITAL_ORGANS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF12
- Parent code in ICD-10
- Q5
- Name in latin
- Retentio testis
Similar endpoints
↥List of similar endpoints to
Undescended testicle
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of genital organs
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 400 | - | 400 |
| Unadjusted period prevalence (%) | 0.18 | - | 0.18 |
| Median age at first event (years) | 6.92 | - | 6.92 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 367
- Matched controls
- 3660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q53.1
ICD-10 Finland
Undescended testicle, unilateral
+∞
323.0
297
*
KFH00
NOMESCO Finland
Operation for undescended or ectopic testis
+∞
198.3
172
*
Q53.2
ICD-10 Finland
Undescended testicle, bilateral
+∞
79.0
73
*
KFH10
NOMESCO Finland
Orchiopexy
119.0
72.0
76
8
Q55.20
ICD-10 Finland
Retractile testis
117.6
48.1
51
5
Q53.9
ICD-10 Finland
Undescended testicle, unspecified
+∞
36.0
34
*
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
9.3
27.4
59
74
KFC00
NOMESCO Finland
Unilateral orchiectomy
19.8
27.2
41
23
G03GA01
ATC
chorionic gonadotrophin; parenteral
37.6
22.4
28
8
ZXD10
NOMESCO Finland
Scheduled procedure
2.9
20.3
177
884
Q53.0
ICD-10 Finland
Ectopic testis
+∞
18.9
18
*
ZXE00
NOMESCO Finland
One hour or less
2.6
16.6
185
1032
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
15.8
146
728
JAH01
NOMESCO Finland
Laparoscopy
14.0
14.9
25
19
7525A
ICD-9 Finland
Congenital anomalies of genital organs, Undescended testicle[RETENTIO TESTIS (CRYPTORCHISMUS)]
16.2
14.6
23
15
ZXA00
NOMESCO Finland
Right side
3.0
14.1
92
365
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
12.1
136
728
H01AC01
ATC
somatropin; parenteral
5.6
12.1
35
67
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.6
11.4
53
163
F82
ICD-10 Finland
Specific developmental disorder of motor function
5.2
11.0
34
71
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
4.9
10.6
34
74
75210
ICD-8 Finland
Congenital anomalies of genital organs, Undescended testicle
112.7
10.5
11
*
Q53
ICD-10 Finland
Undescended testicle
+∞
10.4
10
*
ZXA05
NOMESCO Finland
Left side
2.7
10.4
81
351
7505
FHL
Funicular lysis and orchidopexy
12.6
9.9
17
14
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.5
9.8
85
391
101
Kela drug reimbursment
Anterior pituitary hypofunction
5.8
9.5
26
47
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
8.7
101
538
ZXD20
NOMESCO Finland
Day surgery
2.9
8.4
52
197
E29.1
ICD-10 Finland
Testicular hypofunction
11.1
8.3
15
14
N50.0
ICD-10 Finland
Atrophy of testis
34.0
8.1
10
*
ZXA10
NOMESCO Finland
Bilateral
2.3
8.0
79
387
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
16.1
7.3
11
7
301
Kela drug reimbursment
Growth hormone
6.9
6.9
16
24
R62.0
ICD-10 Finland
Delayed milestone
3.1
6.8
38
133
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
4.3
6.8
24
59
121
Kela drug reimbursment
Severe hypofunction of sexual glands
17.0
6.8
10
6
F83
ICD-10 Finland
Mixed specific developmental disorders
3.1
6.6
35
121
602
Kela drug reimbursment
Children's severe malnutrition
3.7
6.4
26
73
WX110
NOMESCO Finland
Local anesthesy
1.8
6.3
245
1943
Q54.2
ICD-10 Finland
Hypospadias, penoscrotal
+∞
6.3
6
*
Q55.1
ICD-10 Finland
Hypoplasia of testis and scrotum
+∞
6.3
6
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
27.1
6.2
8
*
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: Q17_UNDES_TESTICLE – Undescended testicle
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).