This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Hepatomegaly and splenomegaly, not elsewhere classified
R18_HEPATOM_SPLENO_NOT_ELSEW_CLASSIFIED
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
351 |
4. Check minimum number of eventsNone |
351 |
5. Include endpointsNone |
351 |
6. Filter based on genotype QC (FinnGen only) |
351 |
Control definitions (FinnGen only)
- Control exclude
- R18_SYMPTOMS_SIGNS_INVOLVI_DIGES_SYSTEM_ABDOMEN
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- R1
- Name in latin
- Hepatomegalia et/sive splenomegalia non alibi classificata
Similar endpoints
↥List of similar endpoints to
Hepatomegaly and splenomegaly, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Symptoms and signs involving the digestive system and abdomen
- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 351 | 156 | 195 |
| Unadjusted period prevalence (%) | 0.07 | 0.05 | 0.09 |
| Median age at first event (years) | 53.47 | 49.51 | 56.63 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 326
- Matched controls
- 3260
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
+∞
274.1
223
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
15.7
83.1
151
169
R16.0
ICD-10 Finland
Hepatomegaly, not elsewhere classified
+∞
81.7
75
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
7.9
57.2
163
367
XW000
NOMESCO Finland
Bone marrow biopsy
21.8
56.0
84
51
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
8.8
46.7
112
183
R16.2
ICD-10 Finland
Hepatomegaly with splenomegaly, not elsewhere classified
+∞
45.9
43
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
16.6
40.2
66
49
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
9.9
32.3
68
84
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
29.9
189
847
D73.1
ICD-10 Finland
Hypersplenism
+∞
29.6
28
*
UJF32
NOMESCO Finland
Coloscopy
4.4
26.2
113
349
JMA10
NOMESCO Finland
Transabdominal total splenectomy
79.0
26.2
29
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
7.7
24.6
60
93
JN4BD
NOMESCO Finland
Extensive body CT
5.7
24.4
76
164
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.6
22.2
54
83
R50.9
ICD-10 Finland
Fever, unspecified
4.6
21.9
86
237
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
18.5
20.9
32
19
D64.9
ICD-10 Finland
Anaemia, unspecified
5.8
20.8
63
130
R11
ICD-10 Finland
Nausea and vomiting
13.4
19.6
34
28
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
5.4
19.3
61
132
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
74.3
18.9
21
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
46.9
18.5
22
5
A02BC02
ATC
pantoprazole; systemic
2.9
18.2
216
1319
C03CA01
ATC
furosemide; systemic
3.3
17.8
109
429
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
22.4
17.6
25
12
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
50.2
16.2
19
*
C03DA01
ATC
spironolactone; oral
4.6
16.0
58
145
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
20.5
15.8
23
12
ZX120
NOMESCO Finland
Intravenous
4.8
15.3
53
126
M04AA01
ATC
allopurinol; systemic
4.1
15.3
63
178
WW500
NOMESCO Finland
Blood transfusion
7.9
15.2
35
49
J01MA12
ATC
levofloxacin; systemic
3.5
15.0
78
268
N02AX02
ATC
tramadol; systemic, rectal
2.7
15.0
146
761
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.4
14.2
54
141
H02AB06
ATC
prednisolone; systemic
2.5
13.6
159
899
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
+∞
13.6
13
*
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
+∞
13.6
13
*
R18
ICD-10 Finland
Ascites
145.6
13.5
14
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.4
13.5
41
84
A02BC01
ATC
omeprazole; systemic
2.9
13.5
97
416
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
15.9
13.3
21
14
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
17.6
13.1
20
12
R06.0
ICD-10 Finland
Dyspnoea
3.0
13.1
87
354
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
72.7
12.7
14
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
21.0
12.6
18
9
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
11.7
12.2
22
20
JN3AD
NOMESCO Finland
Abdominal CT examination
6.3
12.1
32
55
A10AE04
ATC
insulin glargine; parenteral
3.8
12.1
53
157
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.1
11.7
24
28
9689/3-C42.2
ICD-O-3
Splenic marginal zone B-cell lymphoma of spleen
+∞
11.5
11
*
Z94.4
ICD-10 Finland
Liver transplant status
124.1
11.5
12
*
UJD02
NOMESCO Finland
Gastroscopy
7.9
11.2
25
34
J01MA02
ATC
ciprofloxacin; systemic
2.4
11.1
128
700
UJF30
NOMESCO Finland
Ileoscopy through colon
4.2
11.1
43
114
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
7.3
11.1
26
38
K76.9
ICD-10 Finland
Liver disease, unspecified
16.2
10.9
17
11
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
8.4
10.8
23
29
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
10.7
87
394
R19.0
ICD-10 Finland
Intra-abdominal and pelvic swelling, mass and lump
62.0
10.7
12
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
8.2
10.6
23
30
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
10.5
78
335
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
10.5
10
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
9.3
10.4
21
24
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.5
10.4
51
166
P01AB01
ATC
metronidazole; oral, rectal
2.3
10.3
118
639
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
4.0
10.3
42
117
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.9
9.9
24
37
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
26.9
9.9
13
5
103
Kela drug reimbursment
Diabetes, insulin-treated
2.4
9.9
101
514
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
56.7
9.7
11
*
D47.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
56.7
9.7
11
*
UJF92
NOMESCO Finland
Capsular endoscopy
10.5
9.6
18
18
D70.89
ICD-10 Finland
Neutropenic splenomegaly
15.6
9.6
15
10
A05AA02
ATC
ursodeoxycholic acid; oral
15.6
9.6
15
10
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
18.2
9.5
14
8
I81
ICD-10 Finland
Portal vein thrombosis
+∞
9.4
9
*
A02BC05
ATC
esomeprazole; systemic
2.2
9.3
119
674
A07AA02
ATC
nystatin; oral
5.9
9.2
25
45
A06AD11
ATC
lactulose; oral
3.1
9.2
53
194
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
7.8
9.1
20
27
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
9.0
64
266
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.5
9.0
31
74
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
24.8
9.0
12
5
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.8
8.9
62
255
N03AX16
ATC
pregabalin; oral
2.5
8.9
77
359
127
Kela drug reimbursment
Transplant complication
11.1
8.9
16
15
ZXE00
NOMESCO Finland
One hour or less
2.1
8.9
134
810
JAH01
NOMESCO Finland
Laparoscopy
6.9
8.8
21
32
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
8.8
98
516
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
4.0
8.8
35
96
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
8.6
92
475
R59.9
ICD-10 Finland
Enlarged lymph nodes, unspecified
28.3
8.5
11
*
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
92.2
8.4
9
*
XF600
NOMESCO Finland
Bloodpressure measurement
4.0
8.4
33
89
D73.9
ICD-10 Finland
Disease of spleen, unspecified
+∞
8.4
8
*
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
8.4
8
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.4
8.3
80
391
WW200
NOMESCO Finland
Immunization
6.3
8.3
21
35
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.0
8.1
47
172
JN4AD
NOMESCO Finland
Body CT examination
3.9
8.1
33
92
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
3.4
8.1
38
120
E66.01
ICD-10 Finland
Obesity due to excess calories
3.7
8.1
34
98
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
22.7
8.1
11
5
K92.0
ICD-10 Finland
Haematemesis
13.5
7.9
13
10
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.1
7.9
108
618
R51.80
ICD-10 Finland
Headache
3.0
7.8
45
164
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
7.8
61
268
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
46.0
7.7
9
*
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
46.0
7.7
9
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.2
7.7
23
47
C07AB07
ATC
bisoprolol; oral
2.0
7.7
144
934
A10BA02
ATC
metformin; oral
2.1
7.5
94
517
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.5
7.5
34
104
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.2
7.4
38
128
D01
ICPC
Abdominal pain/cramps general
3.4
7.4
35
111
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
7.4
72
352
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
8.7
7.4
15
18
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
7.4
93
514
PJA10
NOMESCO Finland
Exploration of lymph nodes
11.2
7.4
13
12
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
7.6
7.3
16
22
J01FF01
ATC
clindamycin; systemic
2.1
7.2
90
493
T90
ICPC
Diabetes non-insulin dependent
2.2
7.2
77
394
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
30.7
7.2
9
*
C83.1
ICD-10 Finland
Mantle cell lymphoma
30.7
7.2
9
*
A10BK03
ATC
empagliflozin; oral
3.6
7.2
31
92
D45
ICD-10 Finland
Polycythaemia vera
12.4
7.1
12
10
Z2221
NOMESCO Finland
Medical doctor
2.1
7.1
96
544
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.2
7.1
80
418
J01DB01
ATC
cefalexin; oral
2.0
7.0
256
2089
N02AA05
ATC
oxycodone; systemic
2.9
7.0
43
162
ZXD05
NOMESCO Finland
Urgent procedure
2.0
7.0
100
580
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
40.9
6.8
8
*
R10.0
ICD-10 Finland
Acute abdomen
17.1
6.8
10
6
N06AA09
ATC
amitriptyline; systemic
3.4
6.8
32
102
L04AD01
ATC
ciclosporin; systemic
7.4
6.8
15
21
WX110
NOMESCO Finland
Local anesthesy
1.9
6.8
226
1772
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.4
6.8
23
55
L03AA02
ATC
filgrastim; parenteral
6.7
6.7
16
25
JN4CD
NOMESCO Finland
Very extensive body CT
4.8
6.7
21
46
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.8
6.7
21
46
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.9
6.7
138
913
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.1
6.6
37
131
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.6
6.6
48
201
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
6.6
65
318
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.6
6.6
28
82
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.0
6.6
37
132
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
10.3
6.6
12
12
A02BC03
ATC
lansoprazole; oral
2.1
6.6
84
465
Z3231
NOMESCO Finland
Registered nurse
2.0
6.5
97
572
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.5
6.5
29
89
374
Kela drug reimbursment
Ruxolitinib
71.1
6.4
7
*
K72.1
ICD-10 Finland
Chronic hepatic failure
71.1
6.4
7
*
174
Kela drug reimbursment
Ruxolitinib
71.1
6.4
7
*
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
71.1
6.4
7
*
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
14.7
6.4
10
7
L01XX05
ATC
hydroxycarbamide; oral
11.3
6.3
11
10
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
9.5
6.3
12
13
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.0
6.3
96
569
A06AC01
ATC
ispaghula (psylla seeds); oral
2.2
6.3
64
321
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.1
6.3
35
123
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
18.4
6.3
9
5
WVA40
NOMESCO Finland
Initiation and monitoring of intravenous hydration
18.4
6.3
9
5
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
+∞
6.3
6
*
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
+∞
6.3
6
*
K74.0
ICD-10 Finland
Hepatic fibrosis
+∞
6.3
6
*
L04AX01
ATC
azathioprine; systemic
4.2
6.2
22
55
K92.1
ICD-10 Finland
Melaena
5.1
6.1
18
37
M54.4
ICD-10 Finland
Lumbago with sciatica
2.5
6.1
49
219
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.4
6.1
28
88
L03AA13
ATC
pegfilgrastim; parenteral
5.7
6.1
16
29
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.7
6.1
25
72
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
6.0
55
260
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
6.0
161
1154
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.1
6.0
22
57
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: R18_HEPATOM_SPLENO_NOT_ELSEW_CLASSIFIED – Hepatomegaly and splenomegaly, not elsewhere classified
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).