Pneumocystosis

AB1_PNEUMOCYSTOSIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B59
  • Hospital discharge: ICD-9 1363
  • Hospital discharge: ICD-8 13601
  • Cause of death: ICD-10 B59
  • Cause of death: ICD-9 1363
  • Cause of death: ICD-8 13601

2 out of 7 registries used, show all original rules.

525

4. Check minimum number of events

None

525

5. Include endpoints

None

525

6. Filter based on genotype QC (FinnGen only)

525

Control definitions (FinnGen only)

Control exclude
AB1_PROTOZOAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2264 930 1311
Only index persons 1857 788 1069
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.04
Only index persons 0.04 0.03 0.04
Median age at first event (years)
Whole population 65.64 66.13 65.45
Only index persons 67.08 67.10 67.08

-FinnGen-

Key figures

All Female Male
Number of individuals 525 235 290
Unadjusted period prevalence (%) 0.11 0.08 0.13
Median age at first event (years) 66.93 66.73 67.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
446
Matched controls
4458
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
+∞
323.0
367
*
TGC00
NOMESCO Finland
Bronchial lavation
67.8
182.0
207
56
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
27.6
144.5
209
138
UGC12
NOMESCO Finland
Flexible bronchoscopy
24.8
143.6
217
164
J18.9
ICD-10 Finland
Pneumonia, unspecified
12.2
122.9
305
673
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
23.5
115.7
174
118
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
22.0
109.4
168
119
B59
ICD-10 Finland
Pneumocystosis
+∞
101.0
93
*
R50.9
ICD-10 Finland
Fever, unspecified
10.5
93.5
217
370
GD1AA
NOMESCO Finland
Thorax X-ray examination
9.5
90.0
372
1545
H02AB06
ATC
prednisolone; systemic
8.1
81.8
360
1517
A49.9
ICD-10 Finland
Bacterial infection, unspecified
9.5
77.5
183
303
XW000
NOMESCO Finland
Bone marrow biopsy
14.1
65.5
118
111
ZX108
NOMESCO Finland
Inhalation
63.1
64.3
74
14
JN4BD
NOMESCO Finland
Extensive body CT
7.8
63.1
168
320
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
14.1
62.9
113
105
L03AA02
ATC
filgrastim; parenteral
19.4
61.6
96
62
ZX120
NOMESCO Finland
Intravenous
8.6
60.2
146
238
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
8.1
58.2
147
254
A03FA01
ATC
metoclopramide; systemic, rectal
5.5
53.8
203
588
WW500
NOMESCO Finland
Blood transfusion
12.4
53.2
101
103
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
15.4
52.8
90
72
H02AB02
ATC
dexamethasone; systemic
7.4
51.7
138
254
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
15.6
50.9
86
67
A04AA01
ATC
ondansetron; systemic, rectal
9.2
50.2
113
158
JN4AD
NOMESCO Finland
Body CT examination
7.6
50.2
131
232
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.4
47.6
255
1029
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
8.1
47.3
116
185
M04AA01
ATC
allopurinol; systemic
5.5
44.1
153
385
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
19.8
42.6
65
38
L03AA13
ATC
pegfilgrastim; parenteral
11.4
42.1
82
86
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.9
41.9
166
480
L04AA06
ATC
mycophenolic acid; systemic
25.0
41.8
59
27
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
18.4
41.5
65
41
J05AB11
ATC
valaciclovir; oral
5.7
39.7
129
296
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
9.9
39.3
83
101
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
7.8
39.3
97
153
J01MA14
ATC
moxifloxacin; systemic
6.6
38.2
107
202
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
21.9
38.1
56
29
127
Kela drug reimbursment
Transplant complication
24.4
38.1
54
25
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.8
37.9
93
145
D70.82
ICD-10 Finland
Drug-induced neutropenia
21.2
37.7
56
30
J01FF01
ATC
clindamycin; systemic
3.9
37.2
206
800
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
13.2
37.2
67
59
Z51.5
ICD-10 Finland
Palliative care
7.4
36.5
93
153
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
375.3
35.5
35
*
J01MA12
ATC
levofloxacin; systemic
4.2
34.8
165
552
A02BC02
ATC
pantoprazole; systemic
4.1
34.6
368
2375
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.7
33.3
132
369
A04AA02
ATC
granisetron; systemic, transdermal
7.0
32.1
85
146
GD1AD
NOMESCO Finland
Thorax CT examination
7.6
32.1
79
122
N02AA05
ATC
oxycodone; systemic
4.4
31.7
133
391
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
5.8
30.4
94
197
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
6.9
30.4
80
136
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.3
30.3
219
1005
C03CA01
ATC
furosemide; systemic
3.4
29.9
201
872
L04AX01
ATC
azathioprine; systemic
8.4
29.8
68
93
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
15.1
29.3
49
36
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
11.4
28.4
54
53
TPH04
NOMESCO Finland
Cathetrisation of vein
3.6
28.2
159
596
TPX10
NOMESCO Finland
Implantation of vascular injection port
11.4
27.9
53
52
L04AD01
ATC
ciclosporin; systemic
14.5
27.1
46
35
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
16.1
27.1
44
30
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.6
26.9
105
282
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
24.4
24.3
34
15
L03AA14
ATC
lipegfilgrastim; parenteral
15.7
23.9
39
27
1CX01
NOMESCO Finland
NA
49.6
23.6
28
6
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
12.1
23.5
43
39
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
23.6
23.4
33
15
ZX112
NOMESCO Finland
Subcutaneous
11.8
23.2
43
40
WW200
NOMESCO Finland
Immunization
9.3
22.8
48
57
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.4
22.3
124
448
1XC02
NOMESCO Finland
NA
40.9
22.0
27
7
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
28.1
21.6
29
11
TK800
NOMESCO Finland
Hemodialysis
11.2
21.1
40
39
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
18.0
20.8
32
19
D70.89
ICD-10 Finland
Neutropenic splenomegaly
18.0
20.8
32
19
H02AB07
ATC
prednisone; oral
3.5
20.5
109
377
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.3
20.4
82
223
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
50.5
20.4
24
5
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
18.4
20.3
31
18
WX892
NOMESCO Finland
Monitored bed care
4.8
20.3
72
173
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
20.0
20.2
30
16
R4110
NOMESCO Finland
Physiotherapy
2.8
20.1
174
837
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
6.0
19.9
57
107
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
12.6
19.6
35
30
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.6
19.4
71
176
H02AB04
ATC
methylprednisolone; systemic
3.3
19.3
109
393
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
18.1
19.0
29
17
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.5
18.5
258
1598
A11CC03
ATC
alfacalcidol; systemic
10.5
18.5
36
37
Z94.0
ICD-10 Finland
Kidney transplant status
17.5
18.1
28
17
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
15.4
17.9
29
20
J05AB01
ATC
aciclovir; systemic
2.8
17.3
131
572
Z49.1
ICD-10 Finland
Extracorporeal dialysis
14.0
17.2
29
22
L04AA01
ATC
[U] ciclosporin; systemic
11.0
17.0
32
31
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
10.4
17.0
33
34
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.4
17.0
220
1290
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
66.0
16.9
19
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.7
16.7
43
70
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.6
16.6
36
45
J02AC03
ATC
voriconazole; systemic
176.3
16.6
17
*
WW300
NOMESCO Finland
Transfer of autologic stem cells
24.2
16.6
23
10
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
8.5
16.1
35
44
JN6AD
NOMESCO Finland
CT of torso and neck
12.9
16.1
28
23
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.7
16.1
76
237
R06.0
ICD-10 Finland
Dyspnoea
2.5
16.0
153
760
B01AB05
ATC
enoxaparin; parenteral
2.4
16.0
178
959
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
5.1
15.6
50
107
WF049
NOMESCO Finland
Radiotherapy of metastasis
6.0
15.4
43
78
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
15.4
174
938
XF400
NOMESCO Finland
ECG with 12 standard connections
2.8
15.2
112
476
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
46.7
15.2
18
*
A41.9
ICD-10 Finland
Sepsis, unspecified
5.7
15.1
44
84
B03XA01
ATC
erythropoietin; parenteral
17.2
14.9
23
14
B01AB10
ATC
tinzaparin; parenteral
3.9
14.9
65
189
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.4
14.8
77
258
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
26.1
14.8
20
8
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.0
14.7
33
44
WX726
NOMESCO Finland
High-flow oxygen therapy
+∞
14.7
14
*
6BA02
NOMESCO Finland
NA
82.9
14.7
16
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
28.3
14.4
19
7
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
20.0
14.4
21
11
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.6
14.2
68
213
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
5.0
14.0
45
97
B25.9
ICD-10 Finland
Cytomegaloviral disease, unspecified
55.2
13.9
16
*
A12AA04
ATC
calcium carbonate; oral
9.8
13.7
27
29
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
77.6
13.7
15
*
J17.3
ICD-10 Finland
Pneumonia in parasitic diseases
144.2
13.5
14
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.6
13.5
115
528
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.8
13.4
58
167
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
11.0
13.4
25
24
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
15.7
13.2
21
14
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.3
13.2
72
247
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.7
13.2
99
423
A07EC01
ATC
sulfasalazine; oral, rectal
3.5
13.2
64
203
B03XA02
ATC
darbepoetin alfa; parenteral
9.2
13.2
27
31
M05BX04
ATC
denosumab; parenteral
4.5
13.1
47
114
L01AA01
ATC
cyclophosphamide; systemic
29.4
13.0
17
6
A05AA02
ATC
ursodeoxycholic acid; oral
12.1
13.0
23
20
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
4.3
12.9
49
125
WX002
NOMESCO Finland
Sedation and analgesia
2.5
12.9
121
586
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.1
12.8
75
271
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.4
12.7
133
679
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
11.0
12.4
23
22
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
14.9
12.4
20
14
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
12.3
78
299
A04AA55
ATC
palonosetron, combinations; systemic
6.9
12.3
30
46
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
6.1
12.2
33
58
AA1BD
NOMESCO Finland
Extensive CT of head and brain
6.1
12.2
33
58
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.6
12.2
103
469
D64.9
ICD-10 Finland
Anaemia, unspecified
3.0
12.2
73
270
C90.0
ICD-10 Finland
Multiple myeloma
9.7
12.1
24
26
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
10.5
12.1
23
23
C83.1
ICD-10 Finland
Mantle cell lymphoma
27.6
12.1
16
6
B02.9
ICD-10 Finland
Zoster without complication
4.3
12.1
45
113
WF004
NOMESCO Finland
Palliative radiotherapy
6.8
12.1
30
47
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.1
11.9
184
1115
HA1AA
NOMESCO Finland
X-ray mammography
4.0
11.7
48
132
TPH07
NOMESCO Finland
Cathetrisation of artery
2.9
11.7
75
290
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.5
11.7
56
176
390
Kela drug reimbursment
Ibrutinib
66.8
11.7
13
*
WX720
NOMESCO Finland
Own respiration
5.0
11.6
37
79
KA1AE
NOMESCO Finland
Kidney ultrasound examination
7.8
11.6
26
35
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.8
11.5
49
139
M05BA04
ATC
alendronic acid; oral
3.4
11.4
57
185
L01AA02
ATC
chlorambucil; oral
36.0
11.3
14
*
H02AB09
ATC
hydrocortisone; systemic
7.2
11.0
26
38
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
44.5
11.0
13
*
C81.1
ICD-10 Finland
Nodular sclerosis classical Hodgkin lymphoma
44.5
11.0
13
*
137
Kela drug reimbursment
Uraemia requiring dialysis
16.0
10.9
17
11
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
10.0
10.9
21
22
WW409
NOMESCO Finland
Other aferesis
28.8
10.8
14
5
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.5
10.7
37
87
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
9.5
10.6
21
23
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
9.5
10.6
21
23
N02AX02
ATC
tramadol; systemic, rectal
2.0
10.6
211
1395
J01DB01
ATC
cefalexin; oral
2.2
10.6
368
3026
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.0
10.5
42
113
XX3DW
NOMESCO Finland
Time consuming IT work
2.8
10.5
71
283
L01BB05
ATC
fludarabine; systemic
112.6
10.5
11
*
L01XE27
ATC
[U] ibrutinib; oral
112.6
10.5
11
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.4
10.4
37
89
RD210
NOMESCO Finland
NA
9.1
10.4
21
24
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.3
10.4
105
520
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
24.0
10.3
14
6
P01BA02
ATC
hydroxychloroquine; oral
3.1
10.3
58
205
TDM10
NOMESCO Finland
Puncture of maxillary antrum
5.2
10.2
31
63
C82.1
ICD-10 Finland
Follicular lymphoma grade II
13.5
10.2
17
13
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
10.2
147
854
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
10.2
46
138
WZC30
NOMESCO Finland
Teaching
2.5
10.2
84
376
A07AA02
ATC
nystatin; oral
3.4
10.1
50
161
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
7.5
10.1
23
32
A04AD12
ATC
aprepitant; systemic
7.3
9.9
23
33
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.4
9.8
35
85
M31.3
ICD-10 Finland
Wegener granulomatosis
56.2
9.7
11
*
YNB10
NOMESCO Finland
Collection of stem cells for transplant
56.2
9.7
11
*
1512
Kela drug reimbursment
Ibrutinib
56.2
9.7
11
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.2
9.7
36
91
3AC01
NOMESCO Finland
NA
15.5
9.6
15
10
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.0
9.6
58
214
TQW99
NOMESCO Finland
Other minor procedure on skin
4.2
9.5
35
88
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
3.5
9.4
44
136
B20.6
ICD-10 Finland
HIV disease resulting in Pneumocystis jirovecii pneumonia
+∞
9.4
9
*
B05DA
ATC
Isotonic solutions
22.3
9.4
13
6
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
4.3
9.4
34
84
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
9.0
9.4
19
22
JN4CD
NOMESCO Finland
Very extensive body CT
4.0
9.4
37
99
N18.0
ICD-10 Finland
End-stage renal disease
9.8
9.3
18
19
ZXA00
NOMESCO Finland
Right side
2.0
9.3
142
838
N03AX16
ATC
pregabalin; oral
2.1
9.3
126
710
R03AC02
ATC
salbutamol; inhalant
1.9
9.2
236
1678
E0000UV
ATC
NA
1.9
9.2
176
1132
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
10.3
9.1
17
17
V03AE02
ATC
sevelamer; oral
37.5
9.1
11
*
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
37.5
9.1
11
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
4.8
9.0
29
64
R2110
NOMESCO Finland
Giving the first information
3.7
8.9
39
114
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
9.8
8.8
17
18
JN3AD
NOMESCO Finland
Abdominal CT examination
2.9
8.8
55
208
XX1XW
NOMESCO Finland
Extensive written report from radiologist
7.4
8.8
20
28
WX725
NOMESCO Finland
Noninvasive ventilation
3.9
8.8
35
95
J70.2
ICD-10 Finland
Acute drug-induced interstitial lung disorders
51.0
8.7
10
*
B23.8
ICD-10 Finland
HIV disease resulting in other specified conditions
51.0
8.7
10
*
J01CA04
ATC
amoxicillin; systemic
2.0
8.7
352
2912
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
4.6
8.6
29
67
J02AC01
ATC
fluconazole; systemic
1.9
8.6
162
1031
C81.9
ICD-10 Finland
Hodgkin lymphoma, unspecified
28.1
8.5
11
*
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
5.0
8.5
26
54
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
20.5
8.5
12
6
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
20.5
8.5
12
6
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
13.1
8.4
14
11
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
5.7
8.4
23
42
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
5.0
8.4
26
55
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
8.8
8.4
17
20
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
11.0
8.3
15
14
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
11.0
8.3
15
14
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.7
8.3
27
60
R11
ICD-10 Finland
Nausea and vomiting
3.0
8.3
47
167
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.9
8.3
49
180
DHA10
NOMESCO Finland
Biopsy of cavity of nose
14.8
8.2
13
9
WX722
NOMESCO Finland
PEEP
3.6
8.2
36
106
V03AE03
ATC
lanthanum carbonate; oral
34.0
8.1
10
*
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
22.5
8.0
11
5
B05DB
ATC
Hypertonic solutions
22.5
8.0
11
5
WX610
NOMESCO Finland
Patient controlled analgesia
22.5
8.0
11
5
PJA10
NOMESCO Finland
Exploration of lymph nodes
7.5
8.0
18
25
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.0
8.0
46
165
TAB00
NOMESCO Finland
Lumbar puncture
3.6
8.0
35
103
R81
ICPC
Pneumonia
4.5
8.0
27
63
N02BE01
ATC
paracetamol; systemic, rectal
2.1
7.9
386
3349
RS220
NOMESCO Finland
NA
8.7
7.9
16
19
K65.0
ICD-10 Finland
Acute peritonitis
11.1
7.8
14
13
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.2
7.8
23
46
WX882
NOMESCO Finland
High dependency care
4.3
7.8
28
69
XG410
NOMESCO Finland
Flow-volume spirometry
3.8
7.7
32
90
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
45.8
7.7
9
*
XF600
NOMESCO Finland
Bloodpressure measurement
3.2
7.7
40
135
EBA10
NOMESCO Finland
Surgical removal of tooth
2.6
7.7
56
234
J96.0
ICD-10 Finland
Acute respiratory failure
8.3
7.7
16
20
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
5.3
7.7
22
43
Z49.2
ICD-10 Finland
Other dialysis
18.7
7.6
11
6
153
Kela drug reimbursment
Lenalidomid
12.1
7.6
13
11
J12.1
ICD-10 Finland
Respiratory syncytial virus pneumonia
12.1
7.6
13
11
TK820
NOMESCO Finland
Peritoneal dialysis
25.5
7.6
10
*
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
9.1
7.6
15
17
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
7.6
207
1473
J12.8
ICD-10 Finland
Other viral pneumonia
10.3
7.6
14
14
AA1AD
NOMESCO Finland
CT of head and brain
1.9
7.6
128
775
SPAT1255
SPAT
Intravenous administration of medicine
2.8
7.5
47
177
SPAT1325
SPAT
Vaccination
1.8
7.4
171
1151
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
81.4
7.4
8
*
N19
ICD-10 Finland
Unspecified kidney failure
4.3
7.4
26
63
C07AB07
ATC
bisoprolol; oral
1.7
7.4
224
1638
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
7.4
70
334
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
11.1
7.3
13
12
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.1
7.3
39
134
1AA09
NOMESCO Finland
NA
+∞
7.3
7
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
7.3
7
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
7.3
7
*
ZX131
NOMESCO Finland
Intrathecal
+∞
7.3
7
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.9
7.3
43
158
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.8
7.3
46
176
D69.5
ICD-10 Finland
Secondary thrombocytopenia
16.1
7.3
11
7
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
4.6
7.3
24
55
J01MA02
ATC
ciprofloxacin; systemic
1.8
7.2
184
1275
B24
ICD-10 Finland
Unspecified human immunodeficiency virus [HIV] disease
30.5
7.2
9
*
A46
ICD-10 Finland
Erysipelas
2.1
7.1
82
425
A49.8
ICD-10 Finland
Other bacterial infections of unspecified site
12.3
7.1
12
10
N18.8
ICD-10 Finland
Other chronic renal failure
4.6
7.1
23
52
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
5.3
7.0
20
39
L04AA13
ATC
leflunomide; oral
4.8
7.0
22
48
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.8
7.0
131
822
A07AA09
ATC
vancomycin; oral
7.7
7.0
15
20
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
6.9
69
338
A02BC05
ATC
esomeprazole; systemic
1.7
6.9
179
1241
R4190
NOMESCO Finland
Nutritional therapy
4.0
6.9
26
68
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
6.9
6.9
16
24
WX110
NOMESCO Finland
Local anesthesy
1.7
6.9
302
2446
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
6.3
6.8
17
28
L04AX04
ATC
lenalidomide; oral
11.2
6.8
12
11
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
40.7
6.8
8
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
40.7
6.8
8
*
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
17.0
6.8
10
6
C08CA01
ATC
amlodipine; oral
1.7
6.8
174
1202
329
Kela drug reimbursment
Lenalidomide
22.9
6.7
9
*
Z94.2
ICD-10 Finland
Lung transplant status
22.9
6.7
9
*
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
22.9
6.7
9
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
22.9
6.7
9
*
ZX121
NOMESCO Finland
Central venous catheter
22.9
6.7
9
*
RS221
NOMESCO Finland
NA
6.6
6.7
16
25
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
6.6
105
621
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
7.0
6.6
15
22
J47
ICD-10 Finland
Bronchiectasis
6.3
6.5
16
26
WW302
NOMESCO Finland
Allogenic transfer of stem cells from relative
70.8
6.4
7
*
9691/3-C77.9
ICD-O-3
Follicular lymphoma, grade 2 of lymph node, NOS
70.8
6.4
7
*
L01XX52
ATC
venetoclax; oral
70.8
6.4
7
*
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
70.8
6.4
7
*
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
14.6
6.4
10
7
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
14.6
6.4
10
7
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
8.3
6.4
13
16
L01BC06
ATC
capecitabine; oral
3.5
6.4
28
84
A03
ICPC
Fever
2.1
6.4
71
363
B02
ICD-10 Finland
Zoster [herpes zoster]
3.8
6.3
25
69
B73
ICPC
Leukaemia
+∞
6.3
6
*
1XX08
NOMESCO Finland
NA
+∞
6.3
6
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
6.3
96
559
C82.2
ICD-10 Finland
Follicular lymphoma grade III, unspecified
27.1
6.2
8
*
WW400
NOMESCO Finland
Plasmaferesis
27.1
6.2
8
*
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
27.1
6.2
8
*
C83.00
ICD-10 Finland
Lymphocytic lymphoma
27.1
6.2
8
*
R06AE07
ATC
cetirizine; oral
1.7
6.2
177
1255
N05CF01
ATC
zopiclone; oral
1.7
6.2
143
950
R28
ICPC
Limited function/disability (R)
7.8
6.2
13
17
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
5.0
6.1
18
37
5BA08
NOMESCO Finland
NA
12.7
6.1
10
8
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
6.8
6.1
14
21
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.1
6.1
22
56
R05
ICD-10 Finland
Cough
1.9
6.1
93
541
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
5.3
6.1
17
33
B99
ICD-10 Finland
Other and unspecified infectious diseases
5.3
6.1
17
33
TGD00
NOMESCO Finland
Needle biopsy of lung
10.2
6.1
11
11
M01CB01
ATC
sodium aurothiomalate; parenteral
6.2
6.0
15
25
A41.8
ICD-10 Finland
Other specified sepsis
6.2
6.0
15
25

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
132
32
54.77
225.75
2.6
1.8
27.3
32.4
%
—
13
5
132
42
41.65
209.95
3.1
1.9
1.0
1.0
e9/l
0.22
95
20
140
61
30.93
200.61
2.3
1.5
—
—
—
0
0
140
61
30.93
200.61
2.3
1.5
—
—
—
0
0
140
61
30.93
200.61
2.3
1.5
—
—
—
0
0
140
61
30.93
200.61
2.3
1.5
—
—
—
0
0
110
32
43.22
178.54
3.5
2.1
435.7
682.7
e6/l
0.71
37
15
107
29
46.09
176.89
2.4
1.8
13.3
12.9
%
0.04
36
16
103
31
41.09
165.29
4.0
2.7
31.8
44.0
%
1.23
29
11
418
1318
11.65
147.44
12.7
4.4
—
—
—
0
0
277
573
9.12
145.38
2.4
1.5
—
—
—
0
0
72
11
75.70
132.86
2.0
1.6
—
—
—
0
0
295
719
8.08
130.14
2.6
2.1
—
—
—
0
0
158
207
10.49
120.23
3.1
1.9
1.0
3.0
ug/l
0.79
148
185
103
72
17.55
117.56
3.2
2.9
—
—
—
0
0
260
629
7.21
112.99
15.3
5.8
1.1
1.0
mmol/l
0.40
254
584
176
294
8.50
108.73
3.1
1.7
1.0
1.4
g/l
1.85
154
272
66
20
37.60
104.63
1.3
1.5
—
—
—
0
0
395
1489
7.67
104.58
21.6
5.6
—
—
—
0
0
197
389
7.51
103.80
9.2
4.3
1.1
0.9
%
0.92
137
123
465
2062
11.98
103.33
23.0
6.2
8.8
8.8
%
0.06
457
1939
277
770
6.50
102.21
8.4
3.6
0.8
0.8
mmol/l
0.72
267
723
238
575
6.74
102.09
2.0
1.8
—
—
—
0
0
74
34
25.17
101.97
3.7
1.9
517.5
451.5
e6/l
0.30
69
27
466
2102
11.83
100.64
22.5
6.0
24.7
27.4
%
3.30
459
1962
453
1990
10.31
100.39
21.8
5.8
0.6
0.7
%
1.71
447
1865
460
2055
11.00
100.07
22.2
5.9
2.1
3.0
%
15.83
452
1924
162
270
8.23
99.64
1.8
1.5
—
—
—
0
0
460
2068
10.89
98.94
20.5
5.8
60.3
57.1
%
4.14
454
1945
473
2199
12.62
97.89
20.2
5.7
0.0
0.0
e9/l
4.05
451
1909
95
79
14.46
97.81
2.7
2.7
—
—
—
0
0
471
2188
12.21
97.27
20.3
5.7
0.6
0.6
e9/l
1.89
448
1888
473
2235
12.27
94.99
20.6
5.8
2.1
1.9
e9/l
0.24
457
1968
475
2262
12.55
94.36
22.8
5.9
0.1
0.2
e9/l
15.42
459
1987
99
94
12.75
93.72
1.5
1.4
—
—
—
0
0
137
203
8.78
92.96
3.1
1.5
10.0
7.6
u/ml
—
11
6
94
84
13.41
92.46
1.5
1.4
88.8
99.4
u/ml
0.32
14
14
190
440
6.20
83.24
2.3
1.6
—
—
—
0
0
90
91
11.73
81.34
2.3
1.6
—
—
—
0
0
212
553
5.75
81.16
5.9
2.6
2.0
1.8
%
1.36
201
507
345
1390
5.32
76.89
14.4
4.0
7.4
7.4
ph
0.56
92
251
482
2578
11.62
76.87
39.9
9.3
4.3
4.1
e9/l
0.92
469
2270
74
60
14.19
76.85
1.6
1.3
—
—
—
0
0
191
484
5.63
74.87
2.0
1.5
—
—
—
0
0
175
417
5.79
73.38
1.7
1.4
—
—
—
0
0
414
1986
6.13
72.82
14.2
5.1
32.7
35.2
g/l
12.43
399
1866
162
363
6.01
72.62
9.8
4.5
0.2
0.1
%
0.54
122
108
82
87
10.98
71.41
1.3
1.3
269.6
288.2
u/ml
0.14
60
48
173
418
5.68
71.22
5.7
2.7
73.1
71.6
e9/l
0.15
126
330
457
2421
7.85
70.46
21.8
6.5
10.1
11.6
umol/l
2.78
451
2297
97
131
8.86
70.24
1.4
1.3
—
—
—
0
0
123
218
7.06
69.91
2.6
2.1
1.6
1.5
g/l
0.07
101
191
156
353
5.86
68.88
9.6
4.2
0.6
0.4
%
1.14
97
86
201
580
5.00
66.58
12.0
8.3
10.5
12.0
kpa
4.44
193
559
201
580
5.00
66.58
12.0
8.3
4.8
5.1
kpa
7.09
193
557
260
920
4.62
66.19
4.7
2.9
545.0
561.4
mosm/kgh2o
0.61
249
778
439
2311
6.49
66.15
24.6
7.3
1.2
1.2
mmol/l
2.36
368
1956
420
2143
5.80
65.44
20.6
6.2
1.2
1.2
mmol/l
2.74
410
1933
198
577
4.90
64.53
12.0
8.4
0.9
1.3
mmol/l
0.56
158
458
56
41
15.17
61.36
1.1
1.2
—
—
—
0
0
261
969
4.37
61.32
4.7
2.6
4.1
5.1
e6/l
0.47
251
852
172
470
4.96
60.25
10.1
4.0
—
—
—
0
0
75
89
9.66
59.87
6.2
2.9
—
—
—
0
0
56
43
14.46
59.70
2.3
2.4
—
—
—
0
0
168
457
4.94
59.06
10.2
3.9
1.9
2.0
mmol/l
0.11
138
362
143
343
5.36
58.37
9.6
4.5
0.0
0.1
%
0.53
99
93
39
14
30.01
58.07
1.5
1.3
—
—
—
0
0
39
15
28.01
56.72
2.6
1.4
—
—
—
0
0
202
655
4.39
56.29
4.4
2.4
2.1
2.3
g/l
4.42
195
607
197
630
4.40
55.88
4.5
2.4
21.8
22.4
%
0.26
179
530
49
34
15.79
55.17
1.6
1.4
0.4
0.4
g/l
0.03
29
25
49
34
15.79
55.17
1.6
1.4
1.9
2.6
g/l
1.11
33
26
49
34
15.79
55.17
1.6
1.4
6.4
7.0
g/l
0.19
30
26
140
346
5.15
54.93
7.7
6.1
—
—
—
0
0
209
711
4.22
54.26
4.4
2.4
11.3
12.8
umol/l
2.39
203
656
65
75
9.75
52.84
8.8
3.5
1.4
1.4
%
0.04
59
63
116
253
5.60
52.38
11.3
10.0
24.2
24.6
mmol/l
0.68
111
237
296
1307
3.90
52.18
6.5
3.3
0.2
0.5
e6/l
2.88
264
989
311
1423
3.91
51.88
6.5
3.4
27.7
105.2
e6/l
1.02
281
1108
48
36
14.57
51.72
1.6
1.4
—
—
—
0
0
287
1256
3.83
50.97
6.4
3.2
—
—
—
0
0
267
1116
3.83
50.78
27.8
6.9
—
—
—
0
0
371
1938
4.12
50.17
13.5
9.4
1.2
1.3
inr
1.62
108
542
60
68
9.83
49.36
1.5
1.8
0.4
0.8
g/l
1.43
40
55
149
420
4.56
49.24
14.0
8.3
—
—
—
0
0
64
80
8.97
48.82
7.5
3.5
58.8
57.9
%
0.13
64
80
168
527
4.22
48.04
13.2
8.6
94.1
95.4
%
1.28
163
507
368
1953
3.96
47.62
34.3
9.6
0.0
0.0
e9/l
0.54
326
1608
147
422
4.45
47.27
2.9
2.0
354.7
379.1
nmol/l
0.41
141
387
64
85
8.44
46.43
2.4
1.3
—
—
—
0
0
44
35
13.63
45.73
1.8
1.1
—
—
—
0
0
327
1636
3.65
45.70
7.8
3.9
23.7
100.7
e6/l
2.77
284
1181
271
1207
3.57
45.53
9.0
2.7
4505.6
7321.2
umol/l
0.47
257
1030
66
93
7.97
45.53
2.2
2.5
14.7
15.6
%
0.55
30
49
231
939
3.61
44.65
16.4
4.6
—
—
—
0
0
105
240
5.22
44.58
9.8
4.0
24.0
24.2
mmol/l
0.18
97
219
169
566
3.93
43.60
1.7
1.3
290.7
461.8
titre
1.30
41
125
230
959
3.49
42.26
2.5
1.7
2.2
1.4
mg/l
0.85
200
742
123
334
4.50
42.16
6.2
2.5
—
—
—
0
0
433
2716
4.39
40.46
14.6
5.0
6.8
6.8
mmol/l
0.05
425
2555
210
859
3.41
39.27
3.1
1.4
2.3
2.6
g/l
0.54
164
508
302
1539
3.27
38.92
10.6
3.6
2.3
2.4
mmol/l
3.54
287
1336
45
50
9.75
37.38
1.5
1.2
—
—
—
0
0
247
1145
3.19
37.00
10.7
4.0
89.2
89.4
%
0.04
240
1126
60
97
6.85
36.39
9.5
3.4
2.7
2.5
mmol/l
0.20
53
67
62
108
6.38
34.96
2.6
1.8
—
—
—
0
0
60
103
6.45
34.31
1.5
1.2
—
—
—
0
0
40
43
9.99
33.99
1.2
1.2
—
—
—
0
0
149
541
3.45
33.00
2.3
1.7
—
—
—
0
0
48
70
7.45
31.91
5.8
6.6
11.6
11.2
mg/l
0.22
43
65
436
2948
3.83
31.84
7.9
4.5
64.8
2551.9
e6/l
—
5
48
67
141
5.30
30.85
4.4
3.2
—
—
—
0
0
272
1446
2.83
30.11
5.9
2.5
—
—
—
0
0
69
154
5.01
29.67
9.0
3.5
56.1
98.2
mg/l
0.48
52
121
229
1129
2.82
29.07
2.9
2.2
3.3
3.1
mg/l
0.50
212
958
262
1387
2.77
28.93
3.9
3.1
—
—
—
0
0
68
154
4.92
28.71
9.1
3.5
58.1
35.0
mg/l
1.18
52
123
268
1442
2.75
28.56
4.6
3.0
2307.3
1254.8
ng/l
2.02
250
1231
38
52
7.80
26.63
1.5
1.2
—
—
—
0
0
83
233
4.04
26.57
1.7
1.3
—
—
—
0
0
24
17
14.75
26.37
1.3
1.2
—
—
—
0
0
89
265
3.84
26.21
20.3
11.7
—
—
—
0
0
434
3075
3.37
26.15
9.3
4.3
—
—
—
0
0
264
1463
2.62
25.75
3.5
2.5
60.8
56.6
u/l
0.49
250
1350
185
872
2.73
24.90
5.6
3.9
195.4
268.1
ng/l
0.32
169
723
135
538
3.03
24.88
7.7
2.9
6.7
9.0
umol/l
1.00
123
480
122
461
3.14
24.64
2.5
2.3
0.2
0.2
g/l
1.49
109
425
334
2104
2.61
24.46
9.6
4.2
—
—
—
0
0
110
394
3.27
24.28
3.7
2.8
186.0
200.5
ng/l
0.15
101
364
53
115
5.01
23.43
9.3
3.6
—
—
—
0
0
19
11
17.88
23.01
4.4
5.6
—
—
—
0
0
19
11
17.88
23.01
1.0
1.0
—
—
—
0
0
22
17
13.46
22.97
1.2
1.2
—
—
—
0
0
103
366
3.26
22.95
7.2
4.2
113.4
82.7
ng/l
2.42
97
325
29
9
34.00
22.64
1.2
1.7
—
—
—
0
0
166
773
2.68
22.56
5.4
3.2
1.5
2.0
e6/l
0.64
109
439
442
3287
3.18
21.99
11.3
4.1
22.3
12.7
mm/h
17.48
434
3001
336
2186
2.49
21.96
6.2
3.7
0.0
0.0
estimate
0.00
100
405
336
2188
2.49
21.89
8.3
5.0
0.0
0.0
estimate
0.00
102
404
92
314
3.34
21.84
5.8
3.7
7.4
7.4
ph
2.62
17
37
111
424
3.05
21.81
4.0
2.4
38.1
33.5
u/l
0.46
100
361
93
321
3.31
21.67
5.8
3.6
4.9
5.1
kpa
1.23
87
295
178
873
2.57
21.62
5.5
3.2
2.5
2.5
mmol/l
0.42
164
765
288
1759
2.41
21.54
5.1
2.6
379.7
149.5
ug/l
2.40
277
1604
337
2216
2.45
21.20
6.3
3.7
0.0
0.0
estimate
0.00
98
383
77
239
3.60
21.16
2.3
1.2
197.4
298.2
u/ml
0.40
67
218
209
1116
2.45
21.03
5.0
2.4
—
—
—
0
0
38
69
5.86
20.38
1.1
1.0
—
—
—
0
0
19
14
14.04
20.32
2.0
1.8
—
—
—
0
0
35
59
6.28
20.22
14.9
3.8
—
—
—
0
0
31
46
7.10
20.17
11.0
3.3
60.0
57.6
%
0.17
23
34
17
11
15.94
19.43
1.2
1.1
—
—
—
0
0
51
125
4.41
19.39
4.6
2.5
24.7
24.7
mmol/l
0.01
46
107
26
34
7.99
18.84
1.5
1.3
104.0
98.8
titre
—
5
8
67
205
3.60
18.75
6.0
4.5
—
—
—
0
0
90
332
3.06
18.62
15.0
8.5
24.5
24.6
mmol/l
0.06
85
309
70
222
3.48
18.54
1.7
1.7
—
—
—
0
0
75
252
3.31
18.13
7.7
2.6
1.3
1.2
%
0.32
75
252
281
1795
2.22
17.69
3.5
2.3
77.9
77.4
nmol/l
0.11
271
1587
45
108
4.46
17.55
2.1
2.1
117.1
128.5
g/l
1.96
32
76
94
369
2.88
17.35
6.8
3.5
—
—
—
0
0
19
19
10.34
16.79
2.2
2.3
62.5
74.0
ug/l
0.18
19
19
199
1135
2.21
16.30
2.0
1.5
18.9
20.6
nmol/l
0.81
181
951
36
77
4.95
16.12
1.1
1.1
—
—
—
0
0
272
1765
2.12
15.87
2.6
2.1
—
—
—
0
0
185
1035
2.22
15.81
5.4
3.7
—
—
—
0
0
27
45
6.27
15.73
1.7
1.1
—
—
—
0
0
27
45
6.27
15.73
1.7
1.1
—
—
—
0
0
27
46
6.13
15.40
1.1
1.0
—
—
—
0
0
161
870
2.23
14.84
1.8
1.7
1201.9
1194.6
nmol/l
0.03
135
661
27
48
5.88
14.75
4.6
2.2
—
—
—
0
0
34
75
4.78
14.68
1.3
1.1
—
—
—
0
0
28
52
5.63
14.63
1.2
1.3
—
—
—
0
0
24
39
6.40
14.32
1.3
1.1
—
—
—
0
0
46
136
3.61
13.48
1.4
1.2
—
—
—
0
0
35
86
4.29
13.23
4.4
2.5
—
—
—
0
0
15
15
10.26
13.18
2.5
2.3
—
—
—
0
0
269
1821
1.98
13.12
5.7
3.7
29.3
46.4
ng/l
1.63
239
1337
18
8
23.23
12.97
1.1
1.0
—
—
—
0
0
16
18
9.14
12.95
4.0
1.8
—
—
—
0
0
33
80
4.33
12.69
1.9
1.2
—
—
—
0
0
17
22
7.95
12.35
2.1
1.5
—
—
—
0
0
108
531
2.30
12.25
5.2
4.3
20.9
37.0
ug/l
0.32
90
453
37
103
3.79
11.83
1.9
1.2
4.4
9.8
e6/l
0.39
32
84
12
10
12.26
11.77
1.2
1.6
—
—
—
0
0
39
114
3.62
11.62
10.5
2.6
—
—
—
0
0
216
1410
1.90
11.25
3.7
2.2
103.4
263.4
u/l
2.25
207
1325
27
64
4.39
10.68
3.7
1.7
31.8
33.4
pg
0.95
27
64
18
31
5.98
10.13
3.0
1.8
—
—
—
0
0
18
31
5.98
10.13
5.3
3.3
—
—
—
0
0
33
95
3.64
10.06
12.0
2.1
57.4
61.0
%
0.41
33
95
186
1194
1.86
9.94
6.8
4.0
0.0
0.0
estimate
0.00
86
392
14
19
7.54
9.74
1.0
1.1
—
—
—
0
0
492
4355
3.06
9.64
70.6
15.3
26.5
25.4
mg/l
0.48
483
3491
11
11
10.19
9.57
1.0
1.2
—
—
—
0
0
11
11
10.19
9.57
1.0
1.2
—
—
—
0
0
11
11
10.19
9.57
1.0
1.2
—
—
—
0
0
87
431
2.22
9.56
2.2
2.6
7.6
5.8
ug/l
0.46
79
383
394
3206
1.92
9.40
6.8
4.0
—
—
—
0
0
46
172
2.84
9.16
5.9
3.3
0.3
0.2
g/l
0.37
40
74
28
77
3.78
9.11
6.5
2.7
—
—
—
0
0
14
21
6.82
8.93
1.0
1.1
—
—
—
0
0
176
1144
1.81
8.84
1.7
1.4
—
—
—
0
0
18
36
5.14
8.67
1.5
1.1
—
—
—
0
0
13
8
16.61
8.59
1.5
1.3
—
—
—
0
0
13
8
16.61
8.59
1.7
1.5
—
—
—
0
0
260
1907
1.72
8.46
2.4
2.0
91.5
94.8
pmol/l
0.52
166
991
20
45
4.58
8.43
1.6
1.3
—
—
—
0
0
23
58
4.10
8.42
1.4
1.2
4.6
8.7
u/ml
—
9
25
56
242
2.47
8.38
7.0
3.7
—
—
—
0
0
21
50
4.33
8.27
1.8
1.2
13486.6
30866.5
e6/l
0.85
14
27
11
14
8.00
8.01
4.1
2.8
—
—
—
0
0
40
152
2.77
7.74
17.8
9.9
1.4
1.2
mmol/l
0.84
35
134
26
77
3.50
7.62
10.2
3.0
37.5
32.3
u/ml
0.16
26
77
15
30
5.12
7.22
1.2
1.2
5.5
6.9
u/l
—
10
24
19
47
4.16
7.14
5.5
3.1
—
—
—
0
0
77
411
2.02
6.91
2.6
1.5
—
—
—
0
0
17
40
4.36
6.80
2.6
2.3
—
—
—
0
0
15
32
4.80
6.73
1.9
1.2
7.9
0.1
u/ml
—
7
19
44
189
2.45
6.68
1.6
1.3
—
—
—
0
0
29
101
2.98
6.58
1.8
1.5
11.0
7.5
u/l
0.50
21
75
112
691
1.79
6.45
1.2
1.3
45.5
14.9
u/ml
0.97
24
265
73
392
2.00
6.43
6.1
3.4
—
—
—
0
0
25
81
3.19
6.40
1.4
1.4
—
—
—
0
0
170
1182
1.65
6.32
6.1
3.4
—
—
—
0
0
9
5
18.28
6.28
1.0
1.0
—
—
—
0
0
114
725
1.73
5.88
1.3
1.3
65.8
38.0
iu/ml
0.80
42
219
14
32
4.47
5.80
1.4
1.2
—
—
—
0
0
25
89
2.90
5.48
1.8
1.6
43.2
23.5
iu/l
1.14
19
74
12
26
4.70
5.28
1.6
1.3
—
—
—
0
0
43
205
2.20
5.18
4.3
3.7
683.8
6816.3
u/ml
0.67
38
175
17
50
3.48
5.06
1.8
1.3
—
—
—
0
0
15
41
3.74
4.96
21.5
2.0
8.2
10.7
%
1.68
15
41
21
72
3.00
4.93
1.4
1.3
—
—
—
0
0
91
572
1.71
4.85
1.5
1.3
—
—
—
0
0
15
42
3.65
4.80
1.9
1.3
33.8
30.1
%
—
10
30
435
3901
1.67
4.70
62.4
16.6
36.2
39.9
%
11.62
286
2644
13
34
3.90
4.56
1.4
1.2
—
—
—
0
0
8
8
10.13
4.53
2.3
1.4
—
—
—
0
0
96
626
1.65
4.45
1.4
1.2
—
—
—
0
0
11
26
4.30
4.37
1.5
1.9
—
—
—
0
0
9
12
7.61
4.37
1.0
1.3
—
—
—
0
0
10
23
4.41
4.10
1.4
1.4
48.1
59.8
%
—
10
16
45
242
1.94
3.98
2.0
2.4
—
—
—
0
0
15
48
3.19
3.96
1.3
1.3
—
—
—
0
0
489
4582
1.98
3.92
66.9
18.1
138.5
139.7
mmol/l
17.09
489
4463
28
127
2.27
3.84
1.4
1.2
84.0
44.3
titre
—
5
7
29
134
2.23
3.81
1.2
1.4
245.5
294.6
ug/g
0.54
15
77
6
5
12.12
3.77
7.3
1.4
10.2
47.6
g/mol
—
6
5
6
5
12.12
3.77
1.3
1.2
—
—
—
0
0
12
35
3.49
3.64
1.2
1.2
—
—
—
0
0
18
69
2.67
3.50
4.6
2.8
4.3
4.0
mmol/l
0.75
18
69
57
347
1.72
3.41
1.9
1.4
—
—
—
0
0
13
42
3.15
3.39
1.5
1.2
—
—
—
0
0
80
533
1.59
3.39
1.4
1.3
—
—
—
0
0
8
14
5.78
3.35
2.8
1.9
—
—
—
0
0
16
60
2.72
3.25
5.6
2.1
8740.7
3174.8
u/l
—
7
21
176
1391
1.40
3.17
5.1
4.0
—
—
—
0
0
6
8
7.57
3.06
10.0
5.0
5.0
6.5
mmol/l
—
6
8
482
4550
1.72
2.99
47.6
14.3
—
—
—
0
0
6
196
0.30
2.99
1.0
1.5
—
—
—
0
0
17
69
2.51
2.99
4.8
2.8
106.8
105.0
mmol/l
0.92
17
69
17
69
2.51
2.99
4.8
2.8
—
—
—
0
0
11
35
3.19
2.94
1.8
1.1
—
—
—
0
0
416
4448
0.69
2.90
5.5
5.3
2.6
2.7
mmol/l
1.28
376
4048
7
13
5.44
2.87
1.0
1.2
—
—
—
0
0
10
31
3.27
2.78
1.4
3.9
—
—
—
0
0
9
23
3.96
2.78
4.9
6.3
—
—
—
0
0
5
6
8.40
2.75
2.8
3.2
—
—
—
0
0
7
14
5.05
2.73
1.0
1.2
—
—
—
0
0
14
54
2.64
2.72
1.9
1.4
—
—
—
0
0
112
1457
0.71
2.71
3.6
3.1
—
—
—
0
0
20
92
2.22
2.70
3.8
3.9
561.3
473.5
u/ml
0.06
20
86
7
15
4.71
2.60
3.6
1.7
26.4
28.9
umol/l
—
7
15
5
7
7.20
2.55
3.0
3.6
—
—
—
0
0
5
7
7.20
2.55
1.2
1.0
—
—
—
0
0
14
56
2.54
2.55
2.3
1.4
58.9
64.7
%
—
8
40
38
225
1.74
2.55
2.5
3.3
4.0
4.5
pmol/l
2.06
32
189
19
88
2.20
2.54
2.5
3.1
1.0
0.9
nmol/l
0.20
14
70
23
116
2.03
2.49
2.3
1.5
8796.4
16096.9
e6/l
0.63
18
84
33
189
1.80
2.47
4.8
3.5
53.3
49.1
u/ml
0.05
33
182
40
243
1.70
2.46
5.3
3.7
—
—
—
0
0
43
267
1.66
2.44
3.8
2.9
0.2
0.3
e6/l
0.09
43
261
8
22
3.68
2.37
1.4
1.4
6.6
1.3
%
—
8
16
9
28
3.25
2.31
1.0
1.1
—
—
—
0
0
14
59
2.41
2.31
2.4
1.6
—
—
—
0
0
13
54
2.44
2.21
1.2
1.1
—
—
—
0
0
411
4352
0.74
2.02
5.2
4.7
4.5
4.6
mmol/l
0.82
378
3978
7
21
3.36
1.97
2.7
1.4
146.7
144.9
nmol/l
—
7
21
5
11
4.58
1.94
8.0
8.4
—
—
—
0
0
6
16
3.78
1.94
1.0
1.1
—
—
—
0
0
357
3281
1.28
1.84
4.3
3.8
14.9
14.9
pmol/l
0.05
333
2930
68
500
1.41
1.83
4.0
2.4
216.5
127.7
ug/g
1.10
57
395
7
23
3.07
1.80
1.1
1.2
—
—
—
0
0
121
980
1.30
1.76
1.6
1.7
473.9
12278910.9
pmol/l
0.79
100
790
410
4324
0.76
1.74
5.0
4.6
1.4
1.4
mmol/l
2.16
375
3934
40
271
1.52
1.64
3.8
3.1
4.4
4.0
e9/l
0.37
34
203
5
133
0.37
1.64
2.2
1.6
—
—
—
0
0
176
1507
1.25
1.63
5.6
3.1
6.7
7.6
mmol/l
2.33
160
1254
18
311
0.56
1.62
1.2
1.4
—
—
—
0
0
29
183
1.62
1.61
2.5
1.8
—
—
—
0
0
169
1444
1.25
1.59
5.9
3.2
1864.8
294.9
mg/l
1.50
127
928
7
26
2.71
1.58
3.3
1.9
—
—
—
0
0
7
26
2.71
1.58
4.0
2.5
63.9
14.2
mu/l
—
7
26
385
3598
1.26
1.58
79.7
20.4
328.6
332.5
g/l
12.43
385
3582
12
57
2.13
1.56
1.7
2.8
3.4
6.2
nmol/l
0.47
12
57
0
44
0.00
1.52
0.0
1.0
—
276.1
—
0
25
0
45
0.00
1.50
0.0
4.0
—
17.7
—
0
34
5
16
3.14
1.44
1.4
1.1
—
—
—
0
0
5
16
3.14
1.44
1.0
1.2
—
—
—
0
0
7
29
2.43
1.39
4.0
1.4
0.9
1.0
g/l
—
7
29
5
18
2.79
1.28
3.6
1.3
—
—
—
0
0
17
99
1.74
1.28
3.0
2.0
—
—
—
0
0
22
139
1.61
1.25
6.2
4.6
—
—
—
0
0
50
375
1.37
1.25
2.7
2.2
9.9
13.0
nmol/l
1.72
42
328
77
616
1.29
1.24
29.8
22.7
1.3
1.3
inr
—
6
85
496
4836
1.46
1.19
88.1
22.3
92.9
91.3
fl
9.63
496
4759
496
4837
1.46
1.18
87.9
22.3
30.6
30.4
pg
1.23
496
4760
171
1522
1.18
1.02
6.0
4.0
14.7
8.1
mg/mmol
1.36
129
959
5
23
2.18
0.98
1.0
1.0
—
—
—
0
0
114
983
1.20
0.97
6.3
4.0
1.0
1.0
kg/l
0.03
15
145
6
28
2.16
0.91
1.3
2.1
—
—
—
0
0
37
280
1.35
0.91
1.4
1.4
—
—
—
0
0
417
4318
0.83
0.91
5.6
4.9
6.1
6.0
mmol/l
0.17
389
3901
399
4146
0.84
0.90
7.4
6.3
40.2
40.4
mmol/mol
0.14
378
3830
8
43
1.87
0.87
1.1
1.1
—
—
—
0
0
6
30
2.01
0.87
1.7
3.8
—
—
—
0
0
10
58
1.74
0.80
1.3
1.2
—
—
—
0
0
95
1084
0.85
0.73
2.1
3.1
0.7
0.8
ug/l
0.41
67
734
37
292
1.29
0.71
3.3
2.6
—
—
—
0
0
15
101
1.50
0.71
1.2
1.3
—
—
—
0
0
9
58
1.56
0.70
1.1
1.2
—
—
—
0
0
32
249
1.30
0.69
1.1
1.2
32.5
155.0
iu/ml
—
10
96
5
27
1.86
0.68
1.0
2.3
7.9
7.2
mmol/l
—
5
18
5
27
1.86
0.68
1.4
1.3
—
—
—
0
0
11
71
1.56
0.62
1.7
1.4
—
—
—
0
0
9
140
0.64
0.61
22.2
12.2
—
—
—
0
0
106
952
1.14
0.57
1.2
1.3
0.9
1.4
u/ml
0.83
22
249
8
122
0.65
0.55
1.0
1.2
—
—
—
0
0
18
134
1.36
0.53
2.1
2.6
169.6
112.5
ug/min
0.31
13
73
27
214
1.28
0.53
2.1
2.9
—
—
—
0
0
7
46
1.53
0.48
1.1
1.2
1.2
1.8
nmol/l
—
7
41
18
138
1.32
0.46
1.0
1.1
—
—
—
0
0
12
87
1.39
0.42
1.1
1.2
—
—
—
0
0
5
32
1.57
0.42
1.2
1.5
1.1
1.4
promille
—
5
25
8
57
1.41
0.42
1.1
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
0.8
—
0
8
0
17
0.00
0.40
0.0
2.6
—
—
—
0
0
5
35
1.43
0.39
1.0
1.2
—
2.7
—
0
5
9
121
0.74
0.35
1.1
1.1
—
—
—
0
0
7
54
1.30
0.30
11.9
1.5
—
—
—
0
0
51
459
1.12
0.30
15.0
4.2
—
—
—
0
0
405
3977
1.08
0.29
5.4
4.6
2.1
2.0
mu/l
0.92
374
3583
37
329
1.13
0.26
1.2
1.2
—
—
—
0
0
411
4170
0.93
0.24
5.0
4.2
1.4
1.3
mmol/l
2.67
376
3772
11
135
0.81
0.22
1.9
1.7
45.4
40.5
nmol/l
0.18
11
128
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
22
195
1.13
0.17
1.0
1.1
—
28.5
—
0
6
31
283
1.10
0.16
1.2
1.2
—
—
—
0
0
12
102
1.18
0.15
7.4
1.4
—
—
—
0
0
41
439
0.93
0.14
1.6
1.6
—
—
—
0
0
12
103
1.17
0.14
7.4
1.4
—
—
—
0
0
12
103
1.17
0.14
7.4
1.4
—
—
—
0
0
12
103
1.17
0.14
1.2
1.6
—
6.0
—
0
28
12
104
1.16
0.12
7.4
1.4
—
—
—
0
0
17
155
1.10
0.09
1.9
1.6
—
—
—
0
0
6
57
1.05
0.08
1.2
1.3
—
—
nmol/l
—
0
0
11
98
1.13
0.07
8.0
1.4
—
—
—
0
0
6
72
0.83
0.07
14.2
1.7
—
—
—
0
0
190
1875
1.02
0.06
4.5
5.1
3.4
2.6
ug/l
0.40
170
1669
127
1253
1.02
0.04
1.7
1.7
1.6
1.3
mmol/l
2.70
114
1040
15
159
0.94
0.03
1.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
20.1
—
0
9
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
1.8
—
0
9
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
30.0
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
0.00
10.5
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_PNEUMOCYSTOSIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_PNEUMOCYSTOSIS 10.609 [7.15, 15.75] < 0.001
Birth year 1.003 [0.99, 1.01] 0.449

During the follow-up period (1.1.1998 — 31.12.2019), 296 out of 647 females with AB1_PNEUMOCYSTOSIS died.

Males

Parameter HR [95% CI] p-value
AB1_PNEUMOCYSTOSIS 5.697 [4.03, 8.05] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 404 out of 853 males with AB1_PNEUMOCYSTOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_PNEUMOCYSTOSIS.

N-year risk Females Males
1 1.668% 1.058%
5 7.866% 6.012%
10 18.753% 14.416%
15 32.72% 25.087%
20 51.67% 40.573%

Relationships between endpoints

Index endpoint: AB1_PNEUMOCYSTOSIS – Pneumocystosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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