Anaphylactic shock due to adverse effect of correct drug or medication properly administered

ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 T88.6#

1 out of 7 registries used, show all original rules.

448

4. Check minimum number of events

None

448

5. Include endpoints

None

448

6. Filter based on genotype QC (FinnGen only)

431

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2507 1626 859
Only index persons 2350 1557 793
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.02
Only index persons 0.05 0.06 0.03
Median age at first event (years)
Whole population 51.79 51.85 51.61
Only index persons 51.56 51.44 51.80

-FinnGen-

Key figures

All Female Male
Number of individuals 431 309 122
Unadjusted period prevalence (%) 0.09 0.11 0.06
Median age at first event (years) 53.49 51.32 58.99

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
448
Matched controls
4480
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
T88.6
ICD-10 Finland
Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
+∞
307.7
448
*
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
126.6
307.7
217
33
C01CA24
ATC
epinephrine; parenteral
15.4
163.9
176
181
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
56.4
162.9
94
21
XQ800
NOMESCO Finland
Prick test
11.9
120.9
147
176
T78.4
ICD-10 Finland
Allergy, unspecified
13.3
97.1
102
97
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
8.4
91.9
150
253
H02AB06
ATC
prednisolone; systemic
5.0
55.1
322
1523
J01FF01
ATC
clindamycin; systemic
3.6
37.9
196
797
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
15.2
37.7
34
24
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
12.5
37.4
38
33
J46
ICD-10 Finland
Status asthmaticus
10.9
36.8
41
41
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
8.6
36.5
49
63
L50.0
ICD-10 Finland
Allergic urticaria
8.6
31.6
42
53
N02AX02
ATC
tramadol; systemic, rectal
3.0
29.2
247
1295
J45.9
ICD-10 Finland
Asthma, unspecified
3.3
27.0
137
534
R03DC03
ATC
montelukast; oral
3.3
26.0
127
482
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.6
25.7
102
340
WX892
NOMESCO Finland
Monitored bed care
4.9
25.4
61
140
R06AE07
ATC
cetirizine; oral
2.8
24.7
261
1497
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
24.4
243
1350
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.4
23.9
106
378
L50.9
ICD-10 Finland
Urticaria, unspecified
5.9
23.9
45
83
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.8
23.7
82
248
R06.0
ICD-10 Finland
Dyspnoea
2.9
23.6
163
747
Y59
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified vaccines and biological substances
30.1
23.5
31
11
X57
ICD-10 Finland
Unspecified privation
8.9
23.4
30
36
X59
ICD-10 Finland
Exposure to unspecified factor
3.1
23.1
122
482
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.9
21.1
129
550
R02
ICPC
Shortness of breath/dyspnoea
3.3
20.6
89
310
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.5
20.6
81
266
N03AX16
ATC
[U] pregabalin
2.8
20.5
140
632
A92
ICPC
Allergy/allergic reaction NOS
5.9
20.4
38
69
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.8
20.1
125
536
R03AC02
ATC
salbutamol; inhalant
2.6
20.1
308
2037
A04AA01
ATC
ondansetron; systemic, rectal
3.9
20.1
65
187
XQ820
NOMESCO Finland
Exposure to medicinal substance
37.7
20.0
25
7
R50.9
ICD-10 Finland
Fever, unspecified
3.1
20.0
99
374
X58
ICD-10 Finland
Exposure to other specified factors
3.0
19.3
101
393
N03AX12
ATC
[U] gabapentin; oral
2.9
19.0
110
453
J01MA12
ATC
levofloxacin; systemic
2.9
19.0
109
447
J01MA02
ATC
ciprofloxacin; systemic
2.5
18.9
203
1130
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.0
18.4
97
379
G43.9
ICD-10 Finland
Migraine, unspecified
3.8
17.5
58
169
X49
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
22.0
17.5
25
12
J45
ICD-10 Finland
Asthma
3.3
17.3
75
261
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.0
17.1
88
338
N02AA05
ATC
oxycodone; systemic
2.8
17.1
100
412
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.4
16.7
153
784
C03CA01
ATC
furosemide; systemic
2.5
16.2
140
697
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
16.1
131
634
R55
ICD-10 Finland
Syncope and collapse
3.2
15.9
70
245
R03BB04
ATC
tiotropium bromide; inhalant
3.4
15.8
62
202
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.0
15.7
78
293
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
15.6
206
1227
J45.1
ICD-10 Finland
Nonallergic asthma
3.7
15.6
54
162
A02BC02
ATC
pantoprazole; systemic
2.4
15.5
329
2383
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
15.4
116
540
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.7
15.2
52
155
R03BA05
ATC
fluticasone; inhalant
2.5
14.9
117
555
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
14.8
63
216
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.1
14.7
67
239
R06AX27
ATC
desloratadine; oral
2.3
14.7
168
939
R42
ICD-10 Finland
Dizziness and giddiness
2.5
14.5
118
568
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.5
14.5
54
170
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
14.5
79
312
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.0
14.4
71
265
R51.80
ICD-10 Finland
Headache
2.5
14.4
107
494
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
14.4
125
620
XQ801
NOMESCO Finland
Intracutantest
14.0
14.4
24
18
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.2
14.3
40
103
H02AB07
ATC
prednisone; oral
2.8
14.0
83
342
S06.0
ICD-10 Finland
Concussion
2.9
13.9
74
288
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
13.9
118
579
Y88.0
ICD-10 Finland
Sequelae of adverse effects caused by drugs, medicaments and biological substances in therapeutic use
77.6
13.7
15
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
13.6
149
814
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.3
13.4
36
90
R11
ICD-10 Finland
Nausea and vomiting
3.0
13.2
63
230
J01FA06
ATC
roxithromycin; oral
2.1
13.1
208
1308
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.6
13.1
87
379
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.7
13.0
83
354
H02AB04
ATC
methylprednisolone; systemic
2.6
12.9
85
369
UJF32
NOMESCO Finland
Coloscopy
2.3
12.9
129
677
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.4
12.6
49
158
AA1AD
NOMESCO Finland
CT of head and brain
2.2
12.4
130
693
JAH01
NOMESCO Finland
Laparoscopy
3.9
12.2
37
101
ZXD05
NOMESCO Finland
Urgent procedure
2.1
12.2
165
972
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.0
12.1
225
1486
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.3
11.9
111
563
ZX120
NOMESCO Finland
Intravenous
2.9
11.7
59
222
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
11.7
138
769
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.1
11.7
143
809
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.7
11.6
27
60
R03AK08
ATC
formoterol and beclometasone; inhalant
3.9
11.3
34
92
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.8
11.3
60
232
R06AE09
ATC
levocetirizine; oral
2.4
11.3
87
405
J01FA09
ATC
clarithromycin; systemic
2.0
11.1
167
1015
XF600
NOMESCO Finland
Bloodpressure measurement
3.4
11.1
42
133
M54.8
ICD-10 Finland
Other dorsalgia
3.7
11.1
36
103
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
11.0
51
183
J01AA02
ATC
doxycycline; systemic
2.3
11.0
363
2911
R01AD58
ATC
fluticasone, combinations; nasal
2.1
10.9
136
771
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
10.9
207
1363
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.1
10.9
47
162
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.1
10.7
139
800
A03FA01
ATC
metoclopramide; systemic, rectal
2.1
10.5
122
672
L50.8
ICD-10 Finland
Other urticaria
8.0
10.5
23
30
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
5.1
10.4
22
45
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.9
10.4
23
49
M54.5
ICD-10 Finland
Low back pain
2.0
10.4
182
1163
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.6
10.3
64
269
R03AK07
ATC
formoterol and budesonide; inhalant
2.1
10.3
114
617
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
4.4
10.2
26
62
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
3.6
10.2
34
99
SPAT1312
SPAT
General health counselling
2.0
10.2
157
958
J01MA14
ATC
moxifloxacin; systemic
2.8
10.2
54
209
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.8
10.2
55
215
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
5.0
10.1
22
46
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.2
10.1
27
67
R03DA04
ATC
theophylline; systemic, rectal
3.7
10.1
33
95
R53
ICD-10 Finland
Malaise and fatigue
2.1
10.1
129
736
Z3231
NOMESCO Finland
Registered nurse
2.0
10.1
139
815
M01AG02
ATC
tolfenamic acid; oral, rectal
2.2
10.0
93
469
WX402
NOMESCO Finland
General anaesthesia
2.1
9.9
108
580
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
11.0
9.9
18
17
XQ802
NOMESCO Finland
Epicutan test
3.7
9.8
32
92
R60.0
ICD-10 Finland
Localized oedema
2.5
9.7
64
277
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
5.0
9.6
21
44
JN3AD
NOMESCO Finland
Abdominal CT examination
2.6
9.6
62
265
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.7
9.6
56
228
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
4.0
9.5
27
70
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.8
9.4
51
199
W84
ICD-10 Finland
Unspecified threat to breathing
30.7
9.4
12
*
L04AB04
ATC
adalimumab; parenteral
5.3
9.4
19
37
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
5.3
9.4
19
37
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
4.8
9.4
21
45
T78.3
ICD-10 Finland
Angioneurotic oedema
9.0
9.4
19
22
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.9
9.4
252
1830
SPAT1229
SPAT
Assessment of need for aid
3.2
9.4
38
126
R03AK03
ATC
[U] fenoterol and ipratropium bromide
3.6
9.4
32
95
N02BE01
ATC
paracetamol; systemic, rectal
2.8
9.3
410
3544
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.6
9.3
60
256
J45.8
ICD-10 Finland
Mixed asthma
4.3
9.3
24
58
A46
ICD-10 Finland
Erysipelas
2.5
9.3
66
295
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.9
9.2
45
166
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
14.1
9.2
15
11
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
3.2
9.2
37
122
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
3.0
9.1
42
150
N06AX21
ATC
duloxetine; oral
2.3
9.0
71
333
M54.4
ICD-10 Finland
Lumbago with sciatica
2.1
9.0
98
525
L01BA01
ATC
methotrexate; systemic
4.2
8.9
24
60
J01DB01
ATC
cefalexin; oral
2.3
8.9
382
3217
G44.2
ICD-10 Finland
Tension-type headache
2.2
8.9
83
418
I50.9
ICD-10 Finland
Heart failure, unspecified
2.6
8.8
56
237
N02AJ06
ATC
codeine and paracetamol; systemic
1.8
8.8
202
1388
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.0
8.8
40
142
R03BA02
ATC
budesonide; inhalant
2.1
8.8
99
536
R25.1
ICD-10 Finland
Tremor, unspecified
4.4
8.8
22
52
SPAT1263
SPAT
Sampling
1.8
8.7
195
1328
C07AB07
ATC
bisoprolol; oral
1.8
8.6
198
1360
N05BA04
ATC
oxazepam; oral
1.9
8.6
135
822
ZXE20
NOMESCO Finland
More than three and less than five hours
2.3
8.5
69
327
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.7
8.5
48
192
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
3.9
8.5
25
67
M89.0
ICD-10 Finland
Algoneurodystrophy
13.1
8.4
14
11
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
8.4
92
492
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
8.4
60
269
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
11.0
8.3
15
14
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
8.3
131
798
R03AC03
ATC
terbutaline; inhalant
2.2
8.2
73
359
J33.0
ICD-10 Finland
Polyp of nasal cavity
4.5
8.2
20
46
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
8.2
105
594
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
8.2
52
220
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
2.8
8.1
41
154
E0000UV, ,
ATC
1.8
8.0
194
1346
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
4.6
8.0
19
43
R01AD09
ATC
mometasone; nasal
1.8
8.0
225
1630
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.6
7.9
26
75
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.9
7.9
142
898
N05CF01
ATC
zopiclone; oral
1.8
7.9
150
965
B01AB05
ATC
enoxaparin; parenteral
1.9
7.9
141
890
L17
ICPC
Foot/toe symptom/complaint
1.9
7.9
139
874
B01AF02
ATC
apixaban; oral
2.5
7.9
50
212
A04
ICPC
Weakness/tiredness general
2.2
7.8
73
366
N03AE01
ATC
clonazepam; systemic
3.1
7.8
33
112
SPAT1301
SPAT
No procedures
1.8
7.8
142
901
M25.5
ICD-10 Finland
Pain in joint
1.8
7.8
163
1079
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
7.8
98
551
Z88.6
ICD-10 Finland
Personal history of allergy to analgesic agent
45.8
7.7
9
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
7.7
150
971
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.9
7.7
23
62
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.4
7.7
54
240
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.2
7.6
66
322
G47.3
ICD-10 Finland
Sleep apnoea
1.9
7.6
106
618
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.9
7.6
37
137
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
7.5
167
1123
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.5
7.5
48
204
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.4
7.5
52
230
J01FA10
ATC
azithromycin; systemic
1.8
7.4
284
2224
N02BF01
ATC
gabapentin; oral
2.5
7.3
47
200
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.4
7.3
18
42
R01AD12
ATC
fluticasone furoate; nasal
1.8
7.2
156
1038
M54.3
ICD-10 Finland
Sciatica
2.9
7.2
34
123
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.8
7.2
135
861
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
7.2
60
287
J38.5
ICD-10 Finland
Laryngeal spasm
30.5
7.2
9
*
KH1AD
NOMESCO Finland
CT of urinary organs
3.9
7.2
21
56
R10.0
ICD-10 Finland
Acute abdomen
3.9
7.2
21
56
N03AX11
ATC
topiramate; oral
3.6
7.1
23
66
N06AX11
ATC
mirtazapine; oral
1.7
7.0
160
1081
R96
ICPC
Asthma
2.4
7.0
52
237
A28
ICPC
Limited function/disability NOS
2.1
7.0
67
340
L03
ICPC
Low back symptom/complaint
1.8
7.0
133
853
WZC00
NOMESCO Finland
Treatment plan or consultation
1.7
7.0
166
1135
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.1
6.9
29
98
S18
ICPC
Laceration/cut
1.7
6.9
196
1404
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
6.9
147
974
R01AD08
ATC
fluticasone; nasal
1.8
6.9
138
898
S93.4
ICD-10 Finland
Sprain and strain of ankle
2.2
6.8
63
314
N01
ICPC
Headache
2.1
6.8
68
350
D10
ICPC
Vomiting
2.7
6.8
37
145
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
6.7
51
234
A02BC03
ATC
lansoprazole; oral
1.8
6.7
127
810
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.4
6.7
46
202
N80.0
ICD-10 Finland
Endometriosis of uterus
4.1
6.7
18
45
SPAT1260
SPAT
Consultation of another employee
2.0
6.7
83
463
128
Kela drug reimbursment
Cancers of female genital organs
6.0
6.7
17
29
J01DC02
ATC
cefuroxime; systemic
2.8
6.7
33
123
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.1
6.7
28
95
R03BB01
ATC
ipratropium bromide; inhalant
3.4
6.7
24
74
SPAT1262
SPAT
Handing over of treatment supplies
2.0
6.6
74
397
P01AB01
ATC
metronidazole; oral, rectal
1.7
6.6
195
1408
M79.6
ICD-10 Finland
Pain in limb
1.7
6.6
193
1390
R05FB02
ATC
cough suppressants and expectorants; systemic
1.7
6.6
169
1175
XQ899
NOMESCO Finland
Other assessment of skin
8.9
6.6
13
15
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.8
6.6
33
124
M01AB05
ATC
diclofenac; systemic, rectal
1.7
6.6
296
2386
N05BA01
ATC
diazepam; systemic, rectal
2.1
6.5
67
348
R03BA01
ATC
beclometasone; inhalant
2.0
6.5
71
377
R06.5
ICD-10 Finland
Mouth breathing
2.4
6.5
47
211
M03BX02
ATC
tizanidine; oral
1.7
6.5
281
2236
WX872
NOMESCO Finland
Intensive care
3.3
6.5
24
75
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.2
6.4
25
81
J01EA01
ATC
trimethoprim; systemic
1.8
6.4
127
821
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.7
6.4
20
56
J01FA15
ATC
telithromycin; oral
2.2
6.4
54
260
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.2
6.4
56
274
H02AB02
ATC
dexamethasone; systemic
2.2
6.4
59
295
L04AX03
ATC
methotrexate; systemic
2.3
6.3
52
247
A03
ICPC
Fever
1.9
6.3
88
509
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.1
6.3
26
87
R5140
NOMESCO Finland
Monitoring the use of the aid
2.2
6.3
54
261
UKC02
NOMESCO Finland
Cystoscopy
2.1
6.3
61
310
N06AX16
ATC
venlafaxine; oral
2.0
6.3
76
419
J01DA09
ATC
[U] cefadroxil
1.8
6.3
123
791
L04AX01
ATC
azathioprine; systemic
3.2
6.3
25
82
A02BC05
ATC
esomeprazole; systemic
1.7
6.3
180
1286
L01
ICPC
Neck symptom/complaint
1.9
6.3
80
450
N20.1
ICD-10 Finland
Calculus of ureter
4.1
6.2
17
43
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
3.5
6.2
21
62
J32.4
ICD-10 Finland
Chronic pansinusitis
6.4
6.2
15
24
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.0
6.2
77
429
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.9
6.2
91
537
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
6.2
46
210
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.3
6.2
49
230
C56.71
ICD-10 Finland
Serous epithelial malignant tumor of the ovary
12.7
6.1
10
8
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
3.6
6.1
20
58
J01DA01
ATC
[U] cefalexin
1.7
6.1
281
2258
ZXE00
NOMESCO Finland
One hour or less
1.7
6.1
181
1303
H53.1
ICD-10 Finland
Subjective visual disturbances
2.5
6.1
38
160
SPAT1254
SPAT
Administration of medicine
2.0
6.1
67
358
SPAT1255
SPAT
Intravenous administration of medicine
2.8
6.1
30
112
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.3
6.0
48
225
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
5.7
6.0
16
29
R04.2
ICD-10 Finland
Haemoptysis
4.0
6.0
17
44
L28
ICPC
Limited function/disability (L)
2.0
6.0
72
396
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.0
6.0
74
411

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
196
852
3.31
33.17
6.4
3.9
—
—
—
0
0
329
2159
2.97
23.44
14.2
9.0
4.35
4.06
e9/l
1.39
305
1887
300
1877
2.81
23.42
7.7
5.8
8.71
10.39
umol/l
6.17
288
1778
299
1903
2.72
21.95
8.5
5.6
2.06
1.97
e9/l
0.22
279
1699
282
1748
2.66
21.78
9.8
6.1
—
—
—
0
0
292
1848
2.67
21.49
8.6
5.6
0.58
0.56
e9/l
0.84
267
1610
291
1850
2.63
21.03
8.6
5.6
0.04
0.04
e9/l
1.09
266
1615
297
1920
2.62
20.50
9.4
6.0
0.21
0.18
e9/l
1.25
276
1699
243
1432
2.52
20.42
6.7
4.3
34.90
36.23
g/l
2.71
227
1353
94
348
3.15
19.63
7.5
6.8
1.36
1.24
mmol/l
0.14
75
284
265
1664
2.45
18.84
9.2
5.8
0.65
0.68
%
0.40
252
1553
246
1496
2.43
18.77
14.2
10.5
1.11
1.17
inr
0.75
87
466
265
1669
2.44
18.64
10.4
6.0
1.20
1.22
mmol/l
2.50
223
1423
272
1734
2.45
18.61
9.7
6.0
8.10
8.36
%
0.76
263
1633
99
389
2.98
18.57
2.1
1.6
—
—
—
0
0
270
1725
2.42
18.24
9.3
5.7
2.89
2.76
%
0.34
259
1620
202
1139
2.41
18.10
3.0
2.3
55.14
57.48
u/l
0.20
187
1057
276
1785
2.42
18.07
9.4
5.8
27.10
28.65
%
1.37
267
1686
274
1767
2.42
18.05
9.0
5.6
58.26
56.90
%
0.99
265
1665
47
115
4.45
17.98
2.5
1.7
9.89
3.64
ug/l
0.32
38
104
117
530
2.63
16.59
5.4
3.0
0.81
0.82
mmol/l
0.15
110
501
299
2052
2.37
16.39
7.1
4.2
6.75
6.52
mmol/l
1.00
291
1884
242
1527
2.27
16.11
8.9
5.2
1.20
1.22
mmol/l
2.18
224
1401
60
192
3.45
15.73
6.1
4.4
—
—
—
0
0
89
361
2.83
15.57
2.4
2.0
388.40
371.76
nmol/l
0.21
82
338
87
349
2.85
15.54
7.9
6.8
4.96
5.13
kpa
0.88
82
337
75
282
2.99
15.04
3.0
2.5
9.75
10.10
g/l
0.34
67
264
156
842
2.31
14.86
2.6
1.7
0.78
1.02
mg/l
1.39
128
645
127
632
2.41
14.53
5.3
3.6
199.84
326.81
ng/l
0.33
86
461
364
2796
2.61
14.47
11.6
7.1
77.16
76.43
u/l
0.13
352
2630
205
1280
2.11
13.21
4.7
3.4
25.56
33.22
ng/l
0.63
136
811
174
1023
2.15
13.11
5.8
3.6
7.42
7.40
ph
1.53
37
186
65
248
2.90
12.62
9.0
6.9
—
—
—
0
0
100
487
2.36
11.77
2.6
1.9
—
—
—
0
0
177
1082
2.05
11.75
3.9
2.7
—
—
—
0
0
317
2386
2.12
11.74
7.1
4.2
358.00
168.49
e6/l
—
10
37
59
222
2.91
11.72
4.4
2.8
205.00
178.52
ng/l
0.20
53
194
67
270
2.74
11.72
5.1
3.0
2.42
2.15
mmol/l
0.20
55
217
151
875
2.09
11.54
3.6
3.1
1665.29
986.02
ng/l
0.47
133
723
192
1243
1.95
10.56
4.7
2.9
40.70
30.13
u/l
0.53
181
1181
63
260
2.66
10.49
1.4
1.4
—
—
—
0
0
324
2512
2.05
10.34
6.7
4.0
—
—
—
0
0
100
525
2.16
9.68
1.6
1.4
916.80
482.17
titre
1.07
25
129
168
1078
1.89
9.20
4.0
2.8
17.87
122.95
e6/l
1.02
146
809
49
192
2.74
9.00
5.1
3.3
7.44
7.40
ph
—
7
22
149
925
1.92
8.99
12.2
6.8
—
—
—
0
0
85
434
2.18
8.77
4.0
2.1
21.24
23.79
%
1.16
63
371
89
463
2.15
8.76
3.9
2.1
2.30
2.38
g/l
0.56
81
431
421
3722
3.18
8.54
29.0
12.4
23.16
21.60
mg/l
0.45
393
2904
121
711
1.96
8.53
3.1
2.6
492.81
541.40
mosm/kgh2o
1.81
113
604
30
91
3.46
8.50
1.2
1.2
676.32
150.54
e6/l
0.54
25
71
30
91
3.46
8.50
1.1
1.1
10.50
2.63
e6/l
0.44
24
68
56
245
2.47
8.24
2.1
2.7
65.07
67.27
g/l
1.49
49
230
189
1294
1.80
8.18
4.7
3.3
70.03
70.62
e6/l
0.01
151
876
137
851
1.88
8.12
2.6
2.0
3.04
2.99
mg/l
0.09
117
729
336
2734
1.92
8.09
6.3
3.9
15.31
10.53
mm/h
5.70
322
2528
64
301
2.31
8.02
4.6
4.2
0.78
0.99
%
0.48
32
109
93
508
2.05
8.01
3.8
2.1
11.40
13.90
umol/l
3.43
87
475
174
1172
1.79
7.89
3.4
3.2
2.33
2.36
mmol/l
2.41
153
1056
21
52
4.19
7.89
2.2
2.5
—
—
—
0
0
40
152
2.79
7.78
9.3
8.1
—
—
—
0
0
311
2484
1.82
7.77
4.3
3.5
—
—
—
0
0
421
3756
3.01
7.72
30.0
13.6
3.94
3.94
mmol/l
0.21
416
3648
190
1322
1.76
7.65
2.1
1.9
93.00
97.39
pmol/l
0.63
114
681
23
63
3.79
7.56
4.5
2.7
3.33
2.85
mmol/l
0.30
13
44
68
337
2.20
7.51
3.4
2.9
1.78
1.78
%
0.00
57
307
36
133
2.86
7.38
1.3
1.3
—
—
—
0
0
23
65
3.68
7.24
6.1
2.2
—
—
—
0
0
233
1740
1.71
7.11
3.4
2.3
—
—
—
0
0
209
1521
1.70
6.98
2.9
2.2
72.79
76.23
nmol/l
0.96
191
1371
52
238
2.34
6.92
4.5
3.3
85.74
74.44
ng/l
0.37
47
216
70
365
2.09
6.78
1.4
1.4
—
—
—
0
0
123
776
1.81
6.77
1.7
1.5
20.46
21.41
nmol/l
0.25
113
662
17
41
4.27
6.60
4.6
3.0
—
—
—
0
0
56
270
2.23
6.60
4.7
4.0
0.58
0.52
%
0.12
24
86
198
1439
1.67
6.52
5.1
3.3
5.78
5.82
ph
0.06
16
131
17
30
5.85
6.51
1.3
1.2
0.24
0.37
u/ml
0.19
12
15
32
119
2.82
6.49
4.6
4.3
—
—
—
0
0
57
282
2.17
6.30
5.0
4.4
0.04
0.12
%
0.76
24
90
51
241
2.26
6.30
2.9
2.4
5.45
5.60
ug/l
0.02
46
216
26
89
3.04
6.10
1.5
1.2
—
—
—
0
0
108
675
1.79
6.07
1.9
1.6
419.50
11652614.78
pmol/l
0.50
94
575
234
1797
1.63
6.06
5.6
3.5
0.00
0.00
estimate
0.50
61
370
57
287
2.13
6.03
2.5
2.3
9.48
18.34
au/ml
—
5
18
18
49
3.79
5.98
6.2
1.6
64.22
63.63
%
0.03
18
49
143
973
1.69
5.93
3.9
2.7
—
—
—
0
0
91
544
1.84
5.90
1.8
1.7
1217.24
1196.65
nmol/l
0.07
68
408
141
960
1.68
5.81
6.5
3.8
0.00
0.00
estimate
0.50
59
344
232
1790
1.61
5.81
6.8
4.8
0.00
0.00
estimate
0.50
58
348
44
204
2.28
5.69
2.3
2.4
—
—
—
0
0
53
267
2.12
5.60
5.1
4.5
0.05
0.16
%
0.43
20
77
16
42
3.91
5.58
1.8
1.4
—
—
—
0
0
23
78
3.05
5.50
1.2
1.2
—
—
—
0
0
19
58
3.38
5.36
2.5
2.4
16.84
16.04
%
—
7
28
232
1815
1.58
5.30
5.5
3.5
0.00
0.01
estimate
0.50
57
338
160
1148
1.61
5.28
2.9
2.1
—
—
—
0
0
141
981
1.64
5.27
4.1
2.7
0.33
0.41
e6/l
0.18
119
716
16
35
4.70
5.22
2.3
1.8
89.42
90.37
%
0.29
16
35
222
1731
1.56
5.07
3.8
2.7
144.74
98.42
ug/l
1.84
208
1609
39
181
2.26
5.04
3.1
2.4
0.74
0.12
e6/l
1.29
39
175
340
2929
1.67
5.04
5.0
4.2
14.60
14.64
pmol/l
0.10
322
2682
105
685
1.70
4.99
1.4
1.3
17.28
33.00
iu/ml
2.56
35
230
33
144
2.39
4.90
5.3
3.4
—
—
—
0
0
306
2577
1.59
4.90
4.1
2.9
52.84
42.66
u/l
1.17
292
2429
19
62
3.16
4.85
2.1
1.5
17906.54
19044.45
e6/l
0.03
13
44
81
498
1.76
4.74
2.5
2.4
198.84
115.97
ug/g
0.87
67
390
116
789
1.63
4.67
6.3
3.7
1.02
1.02
kg/l
0.03
12
106
425
3958
2.44
4.41
16.3
9.6
27.06
25.56
u/l
1.05
415
3833
15
47
3.27
4.09
1.5
1.4
61.50
66.02
mmol/l
—
10
42
140
1027
1.53
4.01
3.5
2.9
8.02
7.73
mmol/l
0.20
122
876
31
145
2.22
3.97
1.2
1.2
—
—
—
0
0
12
27
4.54
3.96
1.6
1.4
—
—
—
0
0
52
296
1.86
3.91
1.8
2.2
0.21
0.23
g/l
0.67
47
278
98
666
1.60
3.91
1.4
1.3
6.90
10.64
u/ml
0.45
40
264
58
342
1.80
3.90
2.7
2.5
38.49
34.33
u/l
0.18
47
288
18
65
2.84
3.90
2.6
3.6
4.70
4.35
e9/l
0.17
18
65
19
71
2.75
3.87
5.8
4.5
26.37
23.63
mg/l
0.14
14
50
8
11
7.38
3.87
1.6
2.8
—
—
—
0
0
131
955
1.53
3.84
3.8
3.4
—
—
—
0
0
6
5
12.14
3.77
1.0
1.0
0.06
0.04
u/ml
—
6
5
18
67
2.76
3.70
2.6
4.0
60.00
55.82
%
0.66
18
67
121
877
1.52
3.62
3.7
2.5
338.76
5883.45
umol/l
3.32
109
775
19
74
2.64
3.60
1.4
1.3
200.46
229.20
u/ml
0.27
13
42
53
312
1.79
3.59
5.2
3.5
—
—
—
0
0
10
21
4.85
3.57
2.5
3.0
1454.50
747.52
u/ml
—
10
21
205
1655
1.44
3.53
16.3
8.8
0.01
0.00
e9/l
0.29
174
1356
137
1027
1.48
3.46
4.6
3.1
—
—
—
0
0
17
64
2.72
3.43
4.0
2.2
—
—
—
0
0
15
53
2.89
3.39
1.3
1.1
2.67
0.76
u/ml
—
10
22
7
10
7.09
3.37
1.0
1.1
—
—
—
0
0
14
48
2.98
3.33
2.1
1.6
—
—
—
0
0
10
23
4.42
3.32
1.8
2.0
42.36
38.44
%
—
10
23
111
808
1.50
3.22
5.5
3.5
—
—
—
0
0
7
11
6.44
3.19
2.7
1.9
56.41
62.95
ug/l
—
7
11
42
240
1.83
3.15
1.8
2.8
72.75
74.44
e9/l
0.12
29
181
123
918
1.47
3.14
4.0
3.1
1815.91
408.06
mg/l
0.83
81
592
66
429
1.63
3.14
1.8
1.3
—
—
—
0
0
9
20
4.57
3.13
1.6
5.9
—
—
—
0
0
13
41
3.23
3.08
4.8
3.5
—
—
—
0
0
378
3469
1.57
3.05
5.9
4.9
1.71
2.18
mu/l
0.75
354
3207
111
818
1.47
3.01
1.9
1.3
2.22
2.24
g/l
0.06
76
510
14
51
2.80
3.01
1.5
1.2
—
—
—
0
0
49
298
1.72
2.99
1.4
1.4
—
—
—
0
0
25
121
2.13
2.99
1.2
1.3
15.10
2.79
u/ml
—
6
17
18
76
2.43
2.93
2.1
1.8
—
—
—
0
0
25
122
2.11
2.93
1.2
1.3
11.17
5.84
u/ml
—
6
26
9
22
4.15
2.89
1.4
1.1
—
—
—
0
0
415
3912
1.83
2.86
24.7
11.5
—
—
—
0
0
22
103
2.19
2.85
1.2
1.1
—
—
—
0
0
14
53
2.69
2.82
4.1
2.0
—
—
—
0
0
8
18
4.50
2.80
1.1
1.1
—
—
—
0
0
8
18
4.50
2.80
4.0
2.5
—
—
—
0
0
9
23
3.97
2.79
4.1
1.5
12.10
11.57
%
—
9
23
126
966
1.42
2.76
4.1
3.6
28.22
7.46
mg/mmol
1.62
83
604
74
514
1.53
2.66
1.4
1.2
—
—
—
0
0
49
309
1.66
2.63
1.1
1.2
—
—
—
0
0
120
919
1.42
2.63
1.2
1.2
0.73
1.40
u/ml
1.51
30
259
24
121
2.04
2.61
1.9
1.3
—
—
—
0
0
7
15
4.72
2.60
1.4
1.2
29.45
30.13
umol/l
—
7
15
69
475
1.54
2.59
2.2
1.5
—
—
—
0
0
11
36
3.11
2.58
2.0
1.2
—
—
—
0
0
37
217
1.77
2.58
1.4
1.2
—
—
—
0
0
22
109
2.07
2.50
4.5
4.1
0.64
0.21
g/l
1.02
12
40
6
12
5.05
2.41
1.8
2.3
—
—
—
0
0
51
334
1.59
2.38
4.9
4.0
16.74
43.82
ug/l
0.52
38
272
10
33
3.08
2.37
1.0
1.1
—
—
—
0
0
43
270
1.66
2.36
5.6
3.4
—
—
—
0
0
110
847
1.40
2.32
2.3
1.9
—
—
—
0
0
21
107
2.01
2.24
2.6
1.8
—
—
—
0
0
76
551
1.46
2.23
3.5
2.5
4.44
2.74
e6/l
0.96
40
281
10
35
2.90
2.22
5.1
3.3
—
—
—
0
0
33
197
1.73
2.19
4.3
2.2
6168.26
3435.75
u/l
0.18
12
83
14
61
2.34
2.16
1.1
1.4
—
—
—
0
0
24
131
1.88
2.12
3.9
1.9
20.94
21.57
s
0.28
17
112
67
479
1.47
2.11
1.3
1.3
—
—
—
0
0
91
689
1.40
2.11
2.0
1.7
—
—
—
0
0
14
62
2.30
2.09
1.1
1.0
—
—
—
0
0
14
62
2.30
2.09
1.1
1.0
—
—
—
0
0
5
10
5.04
2.07
1.0
1.3
—
—
—
0
0
7
20
3.54
2.06
2.1
1.3
0.86
1.41
u/field
—
7
13
432
4170
2.01
2.05
39.5
18.4
39.58
40.25
%
1.37
401
3949
82
614
1.41
2.02
2.9
2.6
2.44
2.45
mmol/l
0.15
68
544
432
4172
1.99
2.02
39.7
18.4
4.45
4.50
e12/l
1.38
427
4061
432
4172
1.99
2.02
39.6
18.4
7.48
6.65
e9/l
4.13
427
4059
8
27
3.00
1.94
4.0
2.4
—
—
—
0
0
6
16
3.79
1.94
2.0
1.8
—
—
—
0
0
30
182
1.69
1.90
1.2
1.1
—
—
—
0
0
13
59
2.24
1.86
1.5
1.4
—
—
—
0
0
5
12
4.20
1.83
1.4
1.7
—
—
—
0
0
5
12
4.20
1.83
1.0
1.5
127.40
126.67
nmol/l
—
5
12
12
53
2.30
1.82
1.2
1.2
—
—
—
0
0
13
61
2.16
1.73
2.6
4.8
—
—
—
0
0
178
1527
1.27
1.72
2.3
2.0
—
—
—
0
0
376
3545
1.38
1.72
4.7
4.1
5.97
5.83
mmol/l
1.16
347
3276
353
3300
1.33
1.68
6.3
5.2
40.59
39.09
mmol/mol
1.53
331
3101
6
19
3.19
1.66
1.2
1.1
1431.67
1788.63
miu/ml
—
6
19
21
120
1.79
1.65
1.2
1.2
—
—
—
0
0
7
27
2.62
1.52
1.1
1.1
—
—
—
0
0
15
79
1.93
1.51
2.5
1.4
—
—
—
0
0
24
148
1.66
1.47
1.5
1.3
270.71
293.94
miu/ml
0.12
17
72
44
314
1.44
1.44
6.2
4.1
—
—
—
0
0
7
29
2.44
1.39
1.9
2.9
—
—
—
0
0
10
47
2.15
1.34
1.2
1.3
—
—
—
0
0
56
424
1.37
1.32
1.3
1.3
—
—
—
0
0
57
433
1.36
1.32
1.6
1.4
—
—
—
0
0
6
24
2.52
1.31
1.8
1.2
—
—
—
0
0
26
170
1.56
1.29
3.0
1.6
—
—
—
0
0
26
171
1.55
1.26
2.8
1.5
—
—
—
0
0
26
171
1.55
1.26
2.9
1.5
—
—
—
0
0
17
100
1.73
1.25
4.4
2.7
—
—
—
0
0
13
70
1.88
1.25
2.7
1.3
78.62
111.76
u/ml
—
5
17
6
25
2.42
1.24
1.0
1.0
—
—
—
0
0
5
19
2.65
1.22
9.8
1.9
—
—
—
0
0
5
19
2.65
1.22
2.0
1.7
—
—
—
0
0
5
19
2.65
1.22
2.0
1.3
—
—
—
0
0
8
39
2.07
1.16
1.5
1.5
—
—
—
0
0
24
159
1.54
1.14
2.8
1.6
—
—
—
0
0
5
114
0.43
1.14
1.2
1.3
—
—
—
0
0
21
135
1.58
1.13
2.2
1.6
—
—
—
0
0
30
417
0.70
1.10
2.0
2.8
0.60
0.69
ug/l
0.20
14
253
5
21
2.40
1.09
1.6
1.4
—
—
—
0
0
7
32
2.21
1.08
1.3
1.2
—
—
—
0
0
367
3507
1.26
1.08
4.0
3.7
1.44
1.25
mmol/l
4.71
336
3250
14
82
1.73
1.06
1.2
1.2
—
—
—
0
0
7
33
2.14
1.06
1.1
1.1
—
—
—
0
0
5
22
2.29
1.03
1.4
1.3
—
—
—
0
0
41
310
1.36
1.01
1.6
1.3
—
—
—
0
0
7
35
2.02
1.00
1.7
1.2
—
—
—
0
0
126
1435
0.83
1.00
2.9
2.7
—
—
—
0
0
5
23
2.19
0.98
1.2
1.2
1932.60
197.29
iu/ml
—
5
23
5
23
2.19
0.98
1.0
1.3
—
—
—
0
0
0
29
0.00
0.98
0.0
7.4
—
—
—
0
0
0
30
0.00
0.97
0.0
1.1
—
—
—
0
0
23
158
1.48
0.95
2.5
1.8
—
—
—
0
0
34
252
1.38
0.95
3.3
2.8
4.29
6.91
e9/l
0.88
27
211
6
28
2.16
0.92
4.5
1.4
21.17
18.04
ug/l
—
6
28
6
29
2.08
0.89
1.0
1.0
—
—
—
0
0
6
29
2.08
0.89
1.5
1.2
—
—
—
0
0
31
229
1.38
0.89
4.1
2.6
—
—
—
0
0
34
445
0.74
0.89
1.3
1.4
—
—
—
0
0
383
3701
1.24
0.85
4.8
4.5
2.87
2.85
mmol/l
0.15
352
3447
24
171
1.43
0.85
3.1
1.5
—
—
—
0
0
20
283
0.69
0.84
1.4
1.4
—
—
—
0
0
53
429
1.27
0.83
1.8
1.8
—
—
—
0
0
0
28
0.00
0.76
0.0
1.6
—
1.05
—
0
28
10
59
1.71
0.76
1.8
1.8
—
—
—
0
0
8
133
0.59
0.74
10.6
8.7
—
—
—
0
0
15
100
1.52
0.73
1.3
1.4
359.11
320.24
ug/g
—
9
56
9
57
1.59
0.71
1.1
1.4
—
30.14
—
0
5
5
93
0.53
0.67
7.4
4.5
—
—
—
0
0
5
28
1.79
0.66
1.4
1.1
—
—
—
0
0
11
71
1.56
0.62
1.1
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
2.7
—
602.64
—
0
11
8
52
1.55
0.59
3.8
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
1.59
—
0
23
373
3628
1.17
0.58
4.4
4.0
1.45
1.50
mmol/l
1.59
344
3382
9
61
1.49
0.54
1.0
1.0
—
—
—
0
0
11
75
1.48
0.51
1.2
1.3
—
—
—
0
0
14
102
1.38
0.48
1.7
2.6
—
—
—
0
0
22
174
1.28
0.46
2.3
2.3
—
—
—
0
0
18
139
1.31
0.44
2.1
1.6
—
—
—
0
0
6
94
0.63
0.42
1.2
1.1
—
—
—
0
0
8
58
1.39
0.41
1.4
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
2.4
—
491.60
—
0
10
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
372
3642
1.13
0.40
4.5
4.1
4.80
4.77
mmol/l
0.17
346
3408
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
9
66
1.37
0.38
1.6
1.8
—
—
—
0
0
6
42
1.43
0.35
1.3
2.0
—
—
—
0
0
6
44
1.37
0.34
1.7
1.2
—
—
nmol/l
—
0
0
7
54
1.30
0.30
1.1
1.2
—
—
—
0
0
36
318
1.14
0.28
1.3
1.2
83.38
167.67
iu/ml
1.92
13
134
76
709
1.09
0.24
3.8
4.5
1.43
2.50
ug/l
1.29
67
632
5
38
1.32
0.23
2.0
3.0
10.70
3.42
nmol/l
—
5
38
5
38
1.32
0.23
1.0
1.3
—
—
—
0
0
5
38
1.32
0.23
1.4
1.9
30.60
32.42
pg
—
5
38
5
40
1.25
0.22
2.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
53
490
1.09
0.21
2.0
1.7
—
—
—
0
0
5
43
1.16
0.21
2.0
2.7
—
—
—
0
0
22
248
0.88
0.18
1.4
1.7
—
—
—
0
0
22
195
1.13
0.17
1.2
1.1
—
—
—
0
0
112
1083
1.05
0.13
1.6
1.5
—
—
—
0
0
11
94
1.17
0.13
5.1
2.5
—
—
—
0
0
5
46
1.09
0.09
1.8
1.1
—
—
—
0
0
5
46
1.09
0.09
1.0
1.0
1.35
1.43
g/l
—
5
41
16
175
0.91
0.08
4.4
3.4
—
—
—
0
0
6
57
1.05
0.08
2.7
1.6
145.50
211.52
pmol/l
—
6
52
26
248
1.05
0.05
1.1
1.2
—
—
—
0
0
98
964
1.02
0.04
1.7
1.6
1.71
1.40
mmol/l
1.96
84
833
11
117
0.94
0.01
1.4
1.5
—
—
—
0
0
10
95
1.05
0.00
7.8
2.2
1.70
1.35
mg/l
—
10
88
11
114
0.96
0.00
1.4
1.4
—
—
—
0
0
11
113
0.97
0.00
1.4
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
4.44
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
73
0.96
-0.00
1.9
2.4
4.59
4.71
umol/l
—
7
57
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE and mortality.

Females

Parameter HR [95% CI] p-value
ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE 2.664 [2.09, 3.4] < 0.001
Birth year 0.994 [0.99, 1.0] 0.195

During the follow-up period (1.1.1998 — 31.12.2019), 249 out of 1378 females with ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE died.

Males

Parameter HR [95% CI] p-value
ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE 2.263 [1.67, 3.07] < 0.001
Birth year 0.989 [0.98, 1.0] 0.023

During the follow-up period (1.1.1998 — 31.12.2019), 140 out of 723 males with ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE died.

Mortality risk

Mortality risk for people of age

years, who have ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE.

N-year risk Females Males
1 0.262% 0.476%
5 1.442% 2.752%
10 3.806% 6.509%
15 7.505% 12.835%
20 12.907% 22.173%

Relationships between endpoints

Index endpoint: ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE – Anaphylactic shock due to adverse effect of correct drug or medication properly administered

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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