No definition available.
Anaphylactic shock due to adverse effect of correct drug or medication properly administered
ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
423 |
4. Check minimum number of eventsNone |
423 |
5. Include endpointsNone |
423 |
6. Filter based on genotype QC (FinnGen only) |
423 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Anaphylactic shock due to adverse effect of correct drug or medication properly administered
based on the number of shared cases.
Similar with more cases:
- Other complications of surgical and medical care, not elsewhere classified
- Complications of surgical and medical care, not elsewhere classified
- Injury, poisoning and certain other consequences of external causes
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2507 | 1626 | 859 |
| Only index persons | 2350 | 1557 | 793 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 51.79 | 51.85 | 51.61 |
| Only index persons | 51.56 | 51.44 | 51.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 423 | 298 | 125 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.06 |
| Median age at first event (years) | 53.02 | 50.66 | 58.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 382
- Matched controls
- 3819
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
T88.6
ICD-10 Finland
Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
+∞
323.0
382
*
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
98.3
173.7
185
36
C01CA24
ATC
epinephrine; parenteral
20.6
89.3
140
104
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
86.5
74.8
82
12
XQ800
NOMESCO Finland
Prick test
10.3
57.4
124
170
T78.4
ICD-10 Finland
Allergy, unspecified
15.1
50.5
87
73
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
7.8
45.9
118
207
H02AB06
ATC
prednisolone; systemic
4.7
43.5
268
1270
N02AX02
ATC
tramadol; systemic, rectal
3.2
25.1
209
1054
J01FF01
ATC
clindamycin; systemic
3.2
22.5
159
702
J45.9
ICD-10 Finland
Asthma, unspecified
3.7
21.5
110
378
Y59
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified vaccines and biological substances
30.9
19.9
26
9
R03DC03
ATC
montelukast; oral
3.6
19.6
103
357
R03AC02
ATC
salbutamol; inhalant
2.7
19.5
248
1541
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.9
19.5
88
270
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
19.1
194
1048
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
18.3
19.0
29
17
R06AE07
ATC
cetirizine; oral
2.6
17.8
215
1267
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.2
17.6
111
439
L50.0
ICD-10 Finland
Allergic urticaria
10.0
17.6
35
38
J46
ICD-10 Finland
Status asthmaticus
10.6
17.5
34
35
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.2
16.4
67
186
R06.0
ICD-10 Finland
Dyspnoea
2.9
16.1
122
537
WX892
NOMESCO Finland
Monitored bed care
5.2
15.9
51
110
X57
ICD-10 Finland
Unspecified privation
12.5
15.8
28
24
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.5
15.6
80
269
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
11.1
15.5
29
28
R50.9
ICD-10 Finland
Fever, unspecified
3.5
15.4
80
272
N03AX12
ATC
gabapentin; oral
3.2
15.3
92
348
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.9
15.1
66
194
X58
ICD-10 Finland
Exposure to other specified factors
3.2
14.5
85
315
A02BC02
ATC
pantoprazole; systemic
2.4
14.2
261
1815
XQ801
NOMESCO Finland
Intracutantest
31.4
14.0
18
6
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.6
13.9
120
567
J01MA02
ATC
ciprofloxacin; systemic
2.4
13.8
166
935
A04AA01
ATC
ondansetron; systemic, rectal
4.2
13.3
52
138
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.9
13.2
92
381
X49
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
17.5
13.1
20
12
J01MA12
ATC
levofloxacin; systemic
2.9
13.1
90
366
N03AX16
ATC
pregabalin; oral
2.6
13.1
113
530
J01FA06
ATC
roxithromycin; oral
2.3
13.0
179
1067
R51.80
ICD-10 Finland
Headache
3.0
12.9
84
333
N02AA05
ATC
oxycodone; systemic
3.2
12.5
71
256
C03CA01
ATC
furosemide; systemic
2.6
12.5
110
521
A92
ICPC
Allergy/allergic reaction NOS
7.9
12.4
28
38
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
12.4
100
448
N02BE01
ATC
paracetamol; systemic, rectal
3.0
12.2
342
2830
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
11.8
128
672
R55
ICD-10 Finland
Syncope and collapse
3.6
11.8
55
170
R03BA05
ATC
fluticasone; inhalant
2.6
11.8
97
440
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
11.8
166
987
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
11.7
120
612
J01AA02
ATC
doxycycline; systemic
2.4
11.6
309
2434
Y88.0
ICD-10 Finland
Sequelae of adverse effects caused by drugs, medicaments and biological substances in therapeutic use
123.6
11.5
12
*
R06AX27
ATC
desloratadine; oral
2.3
11.5
136
741
G43.9
ICD-10 Finland
Migraine, unspecified
4.1
11.5
45
120
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.8
11.4
81
335
L50.9
ICD-10 Finland
Urticaria, unspecified
5.7
11.3
32
60
J01DB01
ATC
cefalexin; oral
2.6
11.3
328
2676
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
4.0
11.3
45
122
R02
ICPC
Shortness of breath/dyspnoea
3.1
11.0
62
222
UJF32
NOMESCO Finland
Coloscopy
2.4
10.9
111
558
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.8
10.7
45
128
X59
ICD-10 Finland
Exposure to unspecified factor
2.5
10.6
93
435
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.1
10.5
195
1283
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.9
10.3
43
121
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.9
10.3
43
121
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.6
10.2
85
385
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.3
10.2
37
92
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.2
10.2
54
185
H02AB07
ATC
prednisone; oral
2.7
10.1
72
298
R42
ICD-10 Finland
Dizziness and giddiness
2.4
10.1
94
452
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
10.0
64
247
J45.1
ICD-10 Finland
Nonallergic asthma
3.7
9.9
43
126
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.3
9.8
105
541
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
9.8
100
501
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.0
9.7
58
213
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.8
9.7
64
254
XF600
NOMESCO Finland
Bloodpressure measurement
4.1
9.6
37
97
XQ820
NOMESCO Finland
Exposure to medicinal substance
22.4
9.4
13
6
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
9.9
9.4
18
19
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.8
9.3
63
251
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
5.6
9.2
26
49
H02AB04
ATC
methylprednisolone; systemic
2.7
9.2
69
292
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.0
9.2
190
1279
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
4.1
9.1
35
92
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
2.2
9.1
100
520
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
9.0
81
381
R03DA04
ATC
theophylline; systemic, rectal
5.1
8.9
27
56
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
8.9
50
178
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
8.6
89
445
R11
ICD-10 Finland
Nausea and vomiting
3.2
8.6
46
159
R06AE09
ATC
levocetirizine; oral
2.4
8.2
71
326
S06.0
ICD-10 Finland
Concussion
2.9
8.2
51
195
J45
ICD-10 Finland
Asthma
2.8
8.1
53
207
JAH01
NOMESCO Finland
Laparoscopy
3.7
8.0
34
98
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.4
8.0
68
311
J01FA10
ATC
azithromycin; systemic
1.9
8.0
242
1834
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
6.3
8.0
20
33
R03BA02
ATC
budesonide; inhalant
2.3
8.0
81
404
R01AD09
ATC
mometasone; nasal
1.9
7.9
186
1291
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
4.7
7.9
26
59
E0000UV
ATC
NA
1.9
7.9
158
1034
N06AX21
ATC
duloxetine; oral
2.6
7.9
59
250
A03FA01
ATC
metoclopramide; systemic, rectal
2.2
7.9
94
502
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.6
7.8
26
60
L17
ICPC
Foot/toe symptom/complaint
2.1
7.8
101
561
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
15.4
7.8
12
8
R03BB04
ATC
tiotropium bromide; inhalant
3.0
7.7
45
165
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.9
7.7
48
183
R05FB02
ATC
cough suppressants and expectorants
1.9
7.6
149
966
AA1AD
NOMESCO Finland
CT of head and brain
2.1
7.6
94
512
R53
ICD-10 Finland
Malaise and fatigue
2.2
7.6
88
464
ZX120
NOMESCO Finland
Intravenous
2.8
7.5
48
186
L50.8
ICD-10 Finland
Other urticaria
6.2
7.5
19
32
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
7.3
39
135
J01DA01
ATC
[U] cefalexin; systemic
1.8
7.3
244
1883
I50.9
ICD-10 Finland
Heart failure, unspecified
2.8
7.2
45
171
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
7.2
80
414
P01AB01
ATC
metronidazole; oral, rectal
1.8
7.1
164
1118
N05CF01
ATC
zopiclone; oral
1.9
7.1
123
757
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
3.9
7.1
28
76
J01MA14
ATC
moxifloxacin; systemic
2.9
7.1
42
156
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
7.0
163
1109
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.9
7.0
118
720
J45.8
ICD-10 Finland
Mixed asthma
5.4
7.0
20
39
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.3
7.0
66
314
D07AC01
ATC
betamethasone; topical
1.9
7.0
132
841
T78.3
ICD-10 Finland
Angioneurotic oedema
7.8
7.0
15
20
M79.6
ICD-10 Finland
Pain in limb
1.9
7.0
140
908
M54.8
ICD-10 Finland
Other dorsalgia
4.0
6.9
26
68
M54.4
ICD-10 Finland
Lumbago with sciatica
2.2
6.9
72
363
R01AD08
ATC
fluticasone; nasal
1.9
6.8
115
702
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.3
6.8
65
314
XQ899
NOMESCO Finland
Other assessment of skin
17.1
6.8
10
6
J33.8
ICD-10 Finland
Other polyp of sinus
7.4
6.8
15
21
M25.5
ICD-10 Finland
Pain in joint
1.9
6.7
123
770
TPH07
NOMESCO Finland
Cathetrisation of artery
2.8
6.7
43
168
L03
ICPC
Low back symptom/complaint
2.0
6.7
101
590
SPAT1312
SPAT
General health counselling
1.8
6.6
131
844
J01FA09
ATC
clarithromycin; systemic
1.8
6.6
137
895
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.2
6.6
72
370
M01AG02
ATC
tolfenamic acid; oral, rectal
2.1
6.5
76
402
J32.4
ICD-10 Finland
Chronic pansinusitis
7.6
6.5
14
19
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.8
6.5
41
158
N05BA04
ATC
oxazepam; oral
1.9
6.5
103
616
T78.0
ICD-10 Finland
Anaphylactic shock due to adverse food reaction
71.0
6.4
7
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.7
6.4
42
166
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.7
6.4
20
44
J01DC02
ATC
cefuroxime; systemic
3.2
6.4
32
107
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.1
6.3
23
59
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.5
6.3
49
212
W84
ICD-10 Finland
Unspecified threat to breathing
27.2
6.3
8
*
R01AD12
ATC
fluticasone furoate; nasal
1.8
6.1
124
802
R03BB01
ATC
ipratropium bromide; inhalant
4.7
6.1
19
42
M54.5
ICD-10 Finland
Low back pain
1.8
6.0
133
883
J01FA15
ATC
telithromycin; oral
2.4
6.0
49
219
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
6.0
116
736
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
282
1760
2.81
22.17
7.6
5.8
8.7
10.5
umol/l
5.97
270
1665
123
502
3.04
22.05
2.3
1.8
—
—
—
0
0
307
2033
2.86
20.95
14.4
8.9
4.3
4.1
e9/l
0.72
283
1773
229
1356
2.50
18.97
6.7
4.2
35.0
36.2
g/l
2.17
214
1274
92
352
3.06
18.16
2.3
1.8
—
—
—
0
0
91
349
3.05
17.87
2.3
1.7
—
—
—
0
0
87
335
3.01
16.90
7.6
6.9
1.3
1.3
mmol/l
0.08
67
270
185
1063
2.32
15.54
3.0
2.4
55.8
56.0
u/l
0.02
172
985
242
1566
2.27
15.15
10.2
6.0
1.2
1.2
mmol/l
2.36
202
1325
83
336
2.83
14.59
8.0
6.9
5.0
5.1
kpa
1.00
78
324
279
1934
2.30
14.54
6.8
4.2
6.7
6.5
mmol/l
0.78
271
1779
84
343
2.81
14.53
2.5
2.0
391.2
371.2
nmol/l
0.25
77
322
344
2625
2.66
14.24
11.5
7.1
77.5
76.5
u/l
0.16
332
2463
41
108
4.10
14.23
2.5
1.8
11.3
3.8
ug/l
0.35
33
99
120
596
2.41
13.83
5.3
3.7
212.4
339.5
ng/l
0.30
80
440
221
1433
2.14
13.10
8.6
5.2
1.2
1.2
mmol/l
1.87
206
1303
105
505
2.44
12.90
5.7
3.0
0.8
0.8
mmol/l
0.55
98
476
191
1177
2.14
12.87
4.3
2.9
—
—
—
0
0
27
56
5.08
12.55
1.9
1.6
—
—
—
0
0
22
39
5.90
12.07
1.8
1.7
—
—
—
0
0
16
20
8.28
11.96
3.2
2.2
—
—
—
0
0
142
800
2.17
11.87
2.6
1.7
0.8
1.0
mg/l
1.32
115
610
24
49
5.13
11.35
1.9
1.6
—
—
—
0
0
190
1210
2.04
11.34
4.5
3.4
26.9
34.4
ng/l
0.55
123
761
299
2243
2.14
11.30
7.1
4.2
397.7
168.5
e6/l
—
9
37
81
366
2.50
11.28
7.1
6.3
103.7
103.9
mmol/l
0.16
74
357
32
84
4.04
11.14
1.7
1.6
—
—
—
0
0
31
80
4.10
11.04
1.7
1.6
—
—
—
0
0
63
257
2.71
10.78
3.8
3.0
2.1
2.2
mmol/l
0.03
50
205
55
209
2.88
10.75
4.5
2.8
200.5
184.8
ng/l
0.11
50
184
142
833
2.06
10.46
3.6
3.1
1745.7
972.0
ng/l
0.51
124
685
21
41
5.34
10.42
1.8
1.5
—
—
—
0
0
56
233
2.62
9.18
2.2
1.5
—
—
—
0
0
21
46
4.75
9.16
1.7
1.4
—
—
—
0
0
23
57
4.21
8.63
1.6
1.6
—
—
—
0
0
177
1183
1.85
8.51
4.8
2.9
41.3
30.0
u/l
0.52
166
1123
18
37
5.04
8.43
1.7
1.4
—
—
—
0
0
15
26
5.94
8.38
1.3
1.2
0.4
0.1
u/ml
—
8
12
54
232
2.52
8.28
2.1
2.7
65.5
67.2
g/l
1.08
47
218
166
1104
1.83
8.00
3.3
3.2
2.3
2.4
mmol/l
2.21
146
987
396
3508
3.02
7.75
28.4
12.5
22.8
21.7
mg/l
0.29
369
2734
51
221
2.49
7.67
4.2
3.4
82.3
74.1
ng/l
0.25
46
201
46
191
2.58
7.56
1.9
1.5
—
—
—
0
0
82
442
2.06
7.33
3.9
2.1
2.3
2.4
g/l
0.56
75
411
78
413
2.09
7.31
3.9
2.1
21.2
23.6
%
0.97
57
354
42
171
2.62
7.18
4.4
3.3
2.5
1.9
mmol/l
0.44
36
127
127
800
1.84
7.16
2.7
2.0
3.1
3.0
mg/l
0.09
108
683
315
2583
1.86
7.11
6.3
3.9
15.6
10.5
mm/h
5.72
301
2390
27
87
3.25
6.99
1.1
1.1
11.0
2.6
e6/l
0.43
22
66
396
3548
2.82
6.80
29.0
13.7
3.9
3.9
mmol/l
0.22
391
3445
10
14
7.29
6.72
2.2
1.4
—
—
—
0
0
118
746
1.81
6.49
2.0
1.5
—
—
—
0
0
176
1250
1.70
6.41
2.1
1.9
92.8
97.7
pmol/l
0.66
103
640
85
486
1.94
6.39
3.7
2.1
11.6
13.8
umol/l
2.75
78
450
10
15
6.80
6.34
2.3
1.3
—
—
—
0
0
10
15
6.80
6.34
2.2
1.5
—
—
—
0
0
216
1636
1.65
6.04
5.9
3.8
—
—
—
0
0
137
923
1.72
5.97
4.0
2.8
0.2
0.4
e6/l
2.18
113
676
48
229
2.24
5.82
2.9
2.4
5.7
5.7
ug/l
0.00
43
205
14
32
4.49
5.81
2.1
1.8
89.4
90.3
%
0.25
14
32
192
1434
1.62
5.53
3.0
2.2
72.5
76.1
nmol/l
0.99
179
1292
12
25
4.91
5.52
1.2
1.0
—
—
—
0
0
219
1691
1.61
5.48
5.6
3.5
0.0
0.0
estimate
0.00
54
325
112
734
1.72
5.32
1.8
1.5
20.2
21.3
nmol/l
0.29
103
626
217
1688
1.59
5.15
6.9
4.7
0.0
0.0
estimate
0.50
54
324
22
76
3.00
5.11
1.4
1.2
—
—
—
0
0
11
23
4.88
5.04
2.0
1.3
—
—
—
0
0
84
517
1.78
4.94
1.9
1.7
1200.4
1203.1
nmol/l
0.01
63
388
99
641
1.71
4.87
1.9
1.6
415.7
12249072.1
pmol/l
0.50
85
547
130
905
1.63
4.85
6.7
3.7
0.0
0.0
estimate
0.50
55
320
18
57
3.25
4.82
2.1
1.5
17906.5
21356.3
e6/l
0.08
13
39
58
321
1.94
4.76
4.2
3.1
—
—
—
0
0
19
63
3.11
4.73
5.7
4.3
119.2
613.8
iu/ml
—
6
9
25
97
2.68
4.73
6.2
3.8
4.0
3.9
mmol/l
0.23
20
87
217
1711
1.55
4.70
5.6
3.5
0.0
0.0
estimate
0.00
53
314
23
86
2.77
4.66
1.4
1.2
—
—
—
0
0
17
54
3.24
4.53
2.1
2.1
17.5
16.0
%
—
5
26
19
65
3.01
4.50
1.5
1.3
—
—
—
0
0
61
350
1.87
4.49
22.2
16.8
1.5
1.3
inr
—
10
47
36
171
2.21
4.43
2.9
2.4
0.8
0.1
e6/l
1.30
36
165
287
2427
1.57
4.41
4.0
2.9
53.6
43.0
u/l
1.13
274
2285
205
1621
1.51
4.24
3.7
2.7
149.8
99.6
ug/l
1.87
191
1510
108
749
1.59
4.00
6.4
3.6
1.0
1.0
kg/l
—
10
100
96
647
1.63
4.00
1.4
1.3
15.4
33.1
iu/ml
3.27
32
211
56
325
1.83
3.98
2.5
2.6
38.9
34.6
u/l
0.18
45
275
19
70
2.79
3.97
1.4
1.3
200.5
228.0
u/ml
0.25
13
41
400
3731
2.33
3.96
16.2
9.6
27.2
25.6
u/l
1.08
390
3613
315
2749
1.57
3.96
5.0
4.2
14.6
14.6
pmol/l
0.02
297
2518
8
11
7.39
3.87
2.0
3.1
—
—
—
0
0
8
11
7.39
3.87
2.0
3.1
—
—
—
0
0
17
60
2.91
3.84
2.5
3.7
4.7
4.4
e9/l
0.14
17
60
170
1313
1.49
3.83
6.0
3.5
—
—
—
0
0
17
62
2.81
3.63
2.5
4.1
59.7
56.2
%
0.49
17
62
34
173
2.05
3.55
2.0
1.7
—
—
—
0
0
17
63
2.77
3.53
1.6
1.3
—
—
—
0
0
17
63
2.77
3.53
1.6
1.3
—
—
—
0
0
6
6
10.12
3.50
1.0
1.0
—
—
—
0
0
7
10
7.10
3.37
2.7
1.8
56.4
66.8
ug/l
—
7
10
24
109
2.27
3.32
2.8
2.3
3.1
3.1
g/l
0.01
16
88
114
834
1.50
3.27
3.7
2.6
338.3
6219.0
umol/l
3.32
102
731
24
110
2.25
3.25
2.4
2.3
7.5
10.3
g/l
2.42
17
98
90
626
1.56
3.25
1.4
1.3
7.4
11.3
u/ml
0.43
37
243
12
38
3.22
3.23
1.1
1.2
—
—
—
0
0
8
15
5.41
3.20
1.3
1.1
—
—
—
0
0
7
11
6.45
3.19
7.4
7.0
—
—
—
0
0
12
39
3.14
3.11
1.2
1.1
—
—
—
0
0
25
119
2.17
3.11
2.7
2.3
7.5
7.4
g/l
0.08
16
92
25
119
2.17
3.11
2.7
2.3
—
—
—
0
0
25
119
2.17
3.11
2.7
2.3
3.2
3.8
g/l
1.74
16
86
20
87
2.36
3.05
1.2
1.1
—
—
—
0
0
50
305
1.73
3.03
2.3
1.9
—
—
—
0
0
23
108
2.19
2.96
1.2
1.2
12.4
6.8
u/ml
—
5
21
27
136
2.05
2.92
2.0
1.7
—
—
—
0
0
10
30
3.39
2.92
1.2
1.1
—
—
—
0
0
15
58
2.64
2.90
1.6
1.4
—
—
—
0
0
15
59
2.60
2.81
1.4
1.1
0.3
1.7
u/ml
—
10
21
19
84
2.32
2.81
1.3
1.4
—
—
—
0
0
8
18
4.51
2.80
1.0
1.2
—
—
—
0
0
356
3275
1.55
2.76
26.9
13.3
39.1
40.0
%
1.12
251
2531
23
113
2.09
2.67
1.2
1.2
—
—
—
0
0
7
15
4.73
2.60
1.4
1.2
29.5
30.1
umol/l
—
7
15
8
20
4.06
2.58
2.9
2.9
1691.0
773.5
u/ml
—
8
20
45
280
1.68
2.56
1.9
2.2
0.2
0.2
g/l
0.76
40
262
74
520
1.51
2.54
3.4
2.6
4.2
2.8
e6/l
0.75
38
266
353
3257
1.51
2.53
5.8
4.9
1.7
2.2
mu/l
0.78
329
3010
119
918
1.41
2.52
4.3
3.8
24.2
7.7
mg/mmol
1.40
78
573
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
21
3.86
2.47
1.0
1.2
—
—
—
0
0
7
17
4.17
2.37
2.1
1.4
0.9
0.9
u/field
—
7
11
279
2487
1.36
2.30
4.7
3.3
—
—
—
0
0
23
120
1.97
2.30
2.5
2.0
—
—
—
0
0
11
41
2.73
2.29
1.2
1.1
—
—
—
0
0
42
265
1.65
2.28
3.9
2.6
60.0
68.8
ml/min/173m2
0.68
19
110
68
482
1.49
2.24
2.1
1.9
—
—
—
0
0
6
14
4.33
2.16
1.2
1.0
—
—
—
0
0
18
88
2.09
2.14
3.1
1.5
—
—
—
0
0
9
31
2.94
2.08
1.9
1.9
—
—
—
0
0
6
15
4.04
2.04
1.0
1.3
—
—
—
0
0
30
179
1.73
2.01
4.3
2.3
6420.8
3611.2
u/l
0.17
11
76
78
581
1.42
2.00
2.8
2.6
2.4
2.5
mmol/l
0.08
65
515
20
105
1.95
1.99
1.9
1.6
—
0.1
—
0
18
5
11
4.59
1.94
1.0
1.1
—
—
—
0
0
23
128
1.84
1.94
2.1
1.9
—
—
—
0
0
22
378
0.56
1.93
1.6
1.7
—
—
—
0
0
13
58
2.28
1.92
2.3
1.3
—
—
—
0
0
21
114
1.89
1.91
1.2
1.1
—
—
—
0
0
8
28
2.89
1.87
2.1
1.4
—
—
—
0
0
5
12
4.20
1.83
1.0
1.1
—
—
—
0
0
9
35
2.60
1.81
1.1
1.1
—
—
—
0
0
8
29
2.79
1.80
1.1
1.1
—
—
—
0
0
107
856
1.33
1.77
1.2
1.3
0.7
1.4
u/ml
1.43
26
243
71
534
1.40
1.73
2.2
2.1
—
—
—
0
0
46
319
1.50
1.71
5.3
3.8
17.6
43.7
ug/l
0.47
36
260
6
19
3.19
1.66
1.2
1.1
1431.7
1788.6
miu/ml
—
6
19
36
238
1.56
1.66
2.1
1.8
—
—
—
0
0
13
63
2.10
1.61
1.2
1.3
—
—
—
0
0
5
15
3.36
1.52
1.0
1.3
—
—
—
0
0
5
15
3.36
1.52
1.6
1.3
—
—
—
0
0
5
15
3.36
1.52
1.6
1.3
—
—
—
0
0
350
3302
1.35
1.52
23.0
11.5
84.5
85.5
ml/min/173m2
0.34
299
2688
16
86
1.89
1.52
2.6
2.5
—
—
—
0
0
7
27
2.62
1.52
1.1
1.3
—
—
—
0
0
20
116
1.76
1.51
2.6
1.8
—
—
—
0
0
14
72
1.98
1.50
1.9
1.4
—
—
—
0
0
23
140
1.68
1.48
1.5
1.3
270.6
292.9
miu/ml
0.11
16
68
10
45
2.25
1.47
1.3
1.1
—
—
—
0
0
71
552
1.34
1.42
3.5
2.5
0.8
1.0
e6/l
0.36
36
298
11
53
2.10
1.39
1.0
1.1
—
—
—
0
0
99
810
1.29
1.38
2.7
2.0
—
—
—
0
0
9
41
2.22
1.37
1.3
1.2
—
—
—
0
0
6
23
2.63
1.37
3.5
1.3
—
—
—
0
0
10
47
2.15
1.34
1.3
1.3
—
—
—
0
0
51
380
1.39
1.33
10.0
6.5
—
—
—
0
0
9
43
2.12
1.31
1.1
1.2
—
—
—
0
0
11
55
2.03
1.28
1.3
1.2
—
—
—
0
0
31
214
1.48
1.22
1.3
1.4
—
—
—
0
0
5
19
2.65
1.22
1.2
2.1
—
—
—
0
0
331
3128
1.27
1.21
6.3
5.2
40.6
39.1
mmol/mol
1.47
311
2941
15
87
1.75
1.16
1.5
1.2
—
—
—
0
0
351
3348
1.28
1.14
4.7
4.1
6.0
5.8
mmol/l
1.16
324
3092
7
30
2.36
1.13
1.3
1.2
—
—
titre
—
0
0
8
40
2.02
1.12
1.3
1.8
—
—
—
0
0
24
160
1.53
1.12
1.3
1.4
—
—
—
0
0
7
32
2.21
1.08
1.3
1.8
—
—
—
0
0
7
32
2.21
1.08
1.3
1.8
—
—
—
0
0
7
32
2.21
1.08
1.3
1.8
—
—
—
0
0
7
32
2.21
1.08
1.1
1.1
—
—
—
0
0
7
33
2.14
1.06
1.1
1.2
—
—
—
0
0
12
67
1.81
1.05
2.8
1.3
78.6
108.5
u/ml
—
5
16
7
34
2.08
1.03
1.3
1.9
—
—
—
0
0
18
115
1.59
1.01
1.0
1.1
—
12.9
—
0
15
7
35
2.02
1.00
1.1
1.2
—
—
—
0
0
5
23
2.19
0.98
1.0
1.2
—
—
—
0
0
30
403
0.72
0.92
2.0
2.9
0.6
0.7
ug/l
0.20
14
247
6
28
2.16
0.92
4.5
1.4
21.2
18.0
ug/l
—
6
28
19
127
1.52
0.90
1.2
1.6
—
—
—
0
0
13
204
0.63
0.88
1.0
1.0
—
—
—
0
0
6
30
2.01
0.87
1.5
1.4
—
—
—
0
0
6
31
1.95
0.84
5.8
3.9
—
—
—
0
0
11
65
1.71
0.83
1.2
1.1
—
—
—
0
0
55
450
1.26
0.80
1.8
1.7
1.4
1.4
%
0.11
43
404
344
3314
1.20
0.76
3.9
3.7
1.4
1.3
mmol/l
4.34
314
3070
5
24
2.10
0.74
1.0
3.5
—
—
—
0
0
5
27
1.86
0.68
1.6
2.9
—
—
—
0
0
7
43
1.64
0.67
2.3
1.5
—
—
—
0
0
10
62
1.63
0.65
2.5
2.0
—
—
—
0
0
5
29
1.73
0.64
1.0
1.0
—
—
—
0
0
360
3499
1.19
0.62
4.8
4.6
2.9
2.8
mmol/l
0.18
330
3254
82
723
1.17
0.58
1.5
1.4
—
—
—
0
0
6
35
1.72
0.58
1.5
1.0
—
—
—
0
0
6
38
1.59
0.54
1.0
1.1
—
—
—
0
0
14
100
1.41
0.52
1.9
1.8
—
—
—
0
0
8
57
1.41
0.42
1.3
1.3
4.0
3.3
ug/l
—
8
49
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
5
35
1.43
0.39
1.6
2.0
—
16.2
—
0
10
34
397
0.84
0.39
4.3
4.0
31.5
31.8
%
0.05
24
269
9
67
1.35
0.38
1.3
1.5
—
—
—
0
0
5
37
1.36
0.37
2.0
3.1
10.7
3.4
nmol/l
—
5
37
6
42
1.43
0.35
1.7
1.5
—
—
—
0
0
6
43
1.40
0.35
1.7
1.5
—
—
—
0
0
6
43
1.40
0.35
1.7
1.5
—
—
—
0
0
6
44
1.37
0.34
1.7
1.5
—
—
—
0
0
350
3432
1.11
0.34
4.3
4.0
1.5
1.5
mmol/l
1.47
322
3197
7
54
1.30
0.30
1.1
1.1
—
—
—
0
0
34
298
1.15
0.29
1.4
1.2
83.4
164.2
iu/ml
1.80
13
127
74
684
1.10
0.28
3.9
4.5
1.4
2.5
ug/l
1.28
65
609
7
91
0.77
0.22
2.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
5
43
1.16
0.21
1.6
1.5
—
—
—
0
0
9
112
0.80
0.20
1.8
1.6
—
—
—
0
0
6
49
1.23
0.20
2.5
2.0
3.6
6.4
u/ml
—
6
43
349
3446
1.07
0.19
4.5
4.1
4.8
4.8
mmol/l
0.14
324
3224
6
53
1.13
0.18
2.7
1.7
145.5
215.7
pmol/l
—
6
48
19
166
1.15
0.18
1.5
1.9
4.0
2.8
mg/l
0.51
14
116
16
140
1.15
0.15
1.6
1.9
—
—
—
0
0
58
548
1.07
0.15
3.6
4.1
23.1
20.8
%
0.16
11
246
10
84
1.20
0.14
1.2
1.5
—
—
—
0
0
14
122
1.15
0.14
1.1
1.3
—
—
—
0
0
12
134
0.89
0.09
1.4
1.4
—
—
—
0
0
12
134
0.89
0.09
1.4
1.4
—
—
—
0
0
12
133
0.90
0.07
1.4
1.4
—
—
—
0
0
12
133
0.90
0.07
1.4
1.4
—
—
—
0
0
8
74
1.08
0.07
1.4
1.8
—
—
—
0
0
89
907
0.98
0.05
1.8
1.6
1.7
1.4
mmol/l
2.00
76
779
13
138
0.94
0.02
2.3
1.4
—
—
—
0
0
14
142
0.99
0.00
1.4
1.5
—
—
—
0
0
24
241
1.00
0.00
1.4
1.5
—
—
—
0
0
16
157
1.02
0.00
1.4
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE | 2.664 [2.09, 3.4] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.195 |
During the follow-up period (1.1.1998 — 31.12.2019), 249 out of 1378 females with ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE | 2.263 [1.67, 3.07] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 140 out of 723 males with ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE died.
Mortality risk
Mortality risk for people of age
years, who have ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.262% | 0.476% |
| 5 | 1.442% | 2.752% |
| 10 | 3.806% | 6.509% |
| 15 | 7.505% | 12.835% |
| 20 | 12.907% | 22.173% |
Relationships between endpoints
↥Index endpoint: ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE – Anaphylactic shock due to adverse effect of correct drug or medication properly administered
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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