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Malignant neoplasm of gum, excluding all cancers (controls excluding all cancers)

C3_GUM_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C03
  • Hospital discharge: ICD-9 143
  • Hospital discharge: ICD-8 143
  • Cause of death: ICD-10 C03
  • Cause of death: ICD-9 143
  • Cause of death: ICD-8 143
  • Cancer registry: Topography ICD-O-3 C03
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

329

4. Check minimum number of events

None

329

5. Include endpoints

None

329

6. Filter based on genotype QC (FinnGen only)

329

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of gum, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 329 162 167
Unadjusted period prevalence (%) 0.06 0.06 0.07
Median age at first event (years) 67.12 68.02 66.24

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
124
Matched controls
1238
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C03.1
ICD-10 Finland
Malignant neoplasm: Lower gum
+∞
113.7
91
*
130
Kela drug reimbursment
Malignant tumour
+∞
85.6
72
*
8070/3-C03.1
ICD-O-3
Squamous cell carcinoma, NOS, of lower gum
+∞
76.1
65
*
EDB00
NOMESCO Finland
Partial excision of mandible
+∞
74.7
64
*
ECA20
NOMESCO Finland
Biopsy of gingiva
358.1
72.8
67
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
57.9
51
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
304.1
56.1
53
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
27.2
54.2
103
189
JDB10
NOMESCO Finland
Percutaneous gastrostomy
275.4
52.4
50
*
GBB00
NOMESCO Finland
Tracheostomy
275.4
52.4
50
*
C03.0
ICD-10 Finland
Malignant neoplasm: Upper gum
+∞
50.5
45
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
373.4
50.0
47
*
SAA03
NOMESCO Finland
Extended examination of mouth
26.5
49.4
109
266
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
+∞
46.9
42
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
21.4
45.5
76
85
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
44.5
40
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
99.4
42.6
45
7
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
281.0
40.4
39
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
+∞
37.4
34
*
EKA10
NOMESCO Finland
Biopsy of cheek
86.7
34.3
37
6
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
31.3
33.7
45
22
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
44.5
32.9
40
13
SBB10
NOMESCO Finland
Teeth copy
26.4
32.0
45
26
EBB10
NOMESCO Finland
Insertion of dental implant
92.5
31.8
34
5
WX408
NOMESCO Finland
General anesthesy, balanced
11.0
31.5
76
156
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
30.0
30.4
41
20
8070/3-C03.0
ICD-O-3
Squamous cell carcinoma, NOS, of upper Gum
+∞
29.3
27
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
63.5
29.2
33
7
A03FA01
ATC
metoclopramide; systemic, rectal
13.0
29.0
57
76
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
11.0
28.9
65
113
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
44.2
27.2
33
10
ZZQ20
NOMESCO Finland
Free microvascular graft of skin, muscle and bone
+∞
25.9
24
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
26.5
25.3
35
18
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
71.5
25.3
28
5
EBB15
NOMESCO Finland
Insertion of dental implant abutment
108.7
24.7
26
*
WX110
NOMESCO Finland
Local anesthesy
13.5
24.7
114
568
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
294.6
24.6
24
*
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
68.2
24.2
27
5
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
7.5
23.8
90
322
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
23.7
22
*
H02AB02
ATC
dexamethasone; systemic
56.9
23.5
27
6
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
22.6
21
*
EBA15
NOMESCO Finland
Extraction of large number of teeth
19.1
21.4
33
23
XX3DW
NOMESCO Finland
Time consuming IT work
20.1
21.2
32
21
A07AA02
ATC
nystatin; oral
13.6
21.1
38
39
EEB00
NOMESCO Finland
Partial excision of maxilla
+∞
20.4
19
*
WF002
NOMESCO Finland
Radical radiotherapy
+∞
20.4
19
*
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
125.2
20.2
21
*
SAA04
NOMESCO Finland
Special inverstigation of mouth
16.2
19.5
32
26
EP1AE
NOMESCO Finland
Neck ultrasound examination
14.2
19.5
34
32
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
+∞
19.3
18
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
19.3
18
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
27.0
19.1
26
12
N02AA05
ATC
oxycodone; systemic
8.0
18.6
47
88
K13.29
ICD-10 Finland
Indefinite leukoplakia
111.2
18.1
19
*
EHA10
NOMESCO Finland
Biopsy of palate
208.6
18.0
18
*
R4190
NOMESCO Finland
Nutritional therapy
37.7
17.7
22
7
ZXE40
NOMESCO Finland
More than seven and less than nine hours
37.7
17.7
22
7
SBA00
NOMESCO Finland
Microbiological examinations
33.0
17.2
22
8
K13.78
ICD-10 Finland
Other change in the oral mucosa
27.8
17.2
23
10
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
14.8
17.2
29
25
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
+∞
17.1
16
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
17.1
16
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
17.1
16
*
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
195.2
16.9
17
*
ZXE90
NOMESCO Finland
More than 22 hours
69.5
16.2
18
*
SXC03
NOMESCO Finland
Other oral or dental procedure
69.5
16.2
18
*
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
+∞
16.0
15
*
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
16.0
15
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
+∞
16.0
15
*
R4110
NOMESCO Finland
Physiotherapy
5.4
15.8
60
184
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
52.1
15.5
18
*
XF612
NOMESCO Finland
Measurement of central venous pressure
+∞
14.9
14
*
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
169.1
14.8
15
*
WZC30
NOMESCO Finland
Teaching
7.8
14.7
36
62
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
18.8
14.6
22
14
WX404
NOMESCO Finland
Intravenous generell anesthesy
6.0
14.5
45
107
ZXE60
NOMESCO Finland
More than 12 and less than 15 hours
60.7
14.2
16
*
SPF20
NOMESCO Finland
Temporary soling for filling
84.3
13.9
15
*
JN4BD
NOMESCO Finland
Extensive body CT
11.4
13.8
26
28
C03.9
ICD-10 Finland
Malignant neoplasm: Gum, unspecified
+∞
13.8
13
*
EEB10
NOMESCO Finland
Maxillectomy
+∞
13.8
13
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
13.8
13
*
WX872
NOMESCO Finland
Intensive care
10.1
13.4
27
33
ZZA00
NOMESCO Finland
Split skin graft
22.1
13.4
19
10
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.2
12.9
81
384
K13.20
ICD-10 Finland
Idiopathic leukoplakia
+∞
12.7
12
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
12.7
12
*
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
+∞
12.7
12
*
EDB20
NOMESCO Finland
Hemimandibulectomy
+∞
12.7
12
*
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
11.2
12.7
24
26
Z51.5
ICD-10 Finland
Palliative care
14.6
12.7
21
17
Z2446
NOMESCO Finland
Social worker
10.1
12.5
25
30
A04AA01
ATC
ondansetron; systemic, rectal
17.0
12.3
19
13
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
52.1
12.2
14
*
EKB00
NOMESCO Finland
Excision of lesion of cheek
+∞
11.6
11
*
A04AD12
ATC
aprepitant; systemic
+∞
11.6
11
*
EDC42
NOMESCO Finland
Mandibular repair with implant
+∞
11.6
11
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
11.6
11
*
C06.9
ICD-10 Finland
Malignant neoplasm: Mouth, unspecified
+∞
11.6
11
*
L43.8
ICD-10 Finland
Other lichen planus
28.1
11.4
15
6
SAA01
NOMESCO Finland
Simple examination of mouth
4.2
11.2
99
598
SXA10
NOMESCO Finland
Epithel biopsy of mouth
31.2
11.0
14
5
ZXE20
NOMESCO Finland
More than three and less than five hours
5.7
10.9
33
74
TPH07
NOMESCO Finland
Cathetrisation of artery
6.3
10.8
30
60
K05.31
ICD-10 Finland
Periodontitis pronounced
6.2
10.7
30
61
RS316
NOMESCO Finland
NA
119.7
10.6
11
*
ECA35
NOMESCO Finland
Complicated excision of lesion of gingiva
119.7
10.6
11
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
10.6
10
*
EJB30
NOMESCO Finland
Excision of lesion of floor of mouth
+∞
10.6
10
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
10.6
10
*
C06.0
ICD-10 Finland
Malignant neoplasm: Cheek mucosa
+∞
10.6
10
*
SPA02
NOMESCO Finland
Preparation for dental prosthetics
26.0
10.5
14
6
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
10.6
10.5
20
22
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
11.6
10.5
19
19
Z3226
NOMESCO Finland
Physiotherapist
4.5
10.2
40
118
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
18.7
10.2
15
9
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
43.9
10.2
12
*
TEA00
NOMESCO Finland
Biopsy of lip
43.9
10.2
12
*
WX402
NOMESCO Finland
General anaesthesia
5.0
9.9
34
87
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
6.6
9.9
26
48
WX730
NOMESCO Finland
Conventional respirator
32.9
9.6
12
*
ECA30
NOMESCO Finland
Excision of lesion of gingiva
32.9
9.6
12
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
107.9
9.6
10
*
EBA00
NOMESCO Finland
Extraction of tooth
3.5
9.5
58
249
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
9.5
9
*
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
9.5
9
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
3.7
9.3
48
179
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
39.9
9.2
11
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
9.8
9.2
18
21
GD1AD
NOMESCO Finland
Thorax CT examination
10.7
9.1
17
18
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
26.3
9.1
12
5
EBA10
NOMESCO Finland
Surgical removal of tooth
6.4
9.0
24
45
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.2
9.0
73
381
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
6.6
9.0
23
41
K05.30
ICD-10 Finland
Periodontitis complex
4.4
8.9
34
97
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
53.9
8.8
10
*
EB1WA
NOMESCO Finland
NA
53.9
8.8
10
*
SPF30
NOMESCO Finland
Soling for prothesis
17.9
8.8
13
8
ZXD10
NOMESCO Finland
Scheduled procedure
3.2
8.7
63
302
B37.08
ICD-10 Finland
Other candidal stomatitis
96.3
8.5
9
*
PH2CD
NOMESCO Finland
Very extensive CT of inferior vena cava, pelvic veins and veins of lower extremity
96.3
8.5
9
*
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
96.3
8.5
9
*
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
96.3
8.5
9
*
SPA05
NOMESCO Finland
Guiding rail
+∞
8.4
8
*
EDC45
NOMESCO Finland
Reconstruction of mandible using bone graft
+∞
8.4
8
*
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
+∞
8.4
8
*
C06.29
ICD-10 Finland
Malignant tumor of the retromolar surface UNS
+∞
8.4
8
*
C06.21
ICD-10 Finland
Malignant tumor of the lower retromolar surface
+∞
8.4
8
*
WX707
NOMESCO Finland
Fiberoscopic intubation
+∞
8.4
8
*
SAA02
NOMESCO Finland
Basic examination of mouth
3.1
8.2
85
510
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
3.1
8.1
58
272
R13
ICD-10 Finland
Dysphagia
6.1
7.8
21
40
SPF11
NOMESCO Finland
Fitting of dental prosthesis
48.1
7.8
9
*
SPA48
NOMESCO Finland
Precision impression for denture, demanding
48.1
7.8
9
*
SPF00
NOMESCO Finland
Repatation of teeth prosthesis
8.0
7.8
17
24
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
11.1
7.8
14
14
SPF10
NOMESCO Finland
Demanding repatation of teeth prosthesis
14.6
7.6
12
9
WF049
NOMESCO Finland
Radiotherapy of metastasis
85.0
7.5
8
*
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
85.0
7.5
8
*
TJD20
NOMESCO Finland
Change of gastrostomy tube
85.0
7.5
8
*
K12.10
ICD-10 Finland
Stomatitis NOS
85.0
7.5
8
*
C04.0
ICD-10 Finland
Malignant neoplasm: Anterior floor of mouth
+∞
7.4
7
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
7.4
7
*
EDW99
NOMESCO Finland
Other operation on mandible
+∞
7.4
7
*
ZZQ40
NOMESCO Finland
Free microvascular graft of bone
+∞
7.4
7
*
8070/3-C03.9
ICD-O-3
Squamous cell carcinoma, NOS, of gum, NOS
+∞
7.4
7
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
7.4
7
*
EKC20
NOMESCO Finland
Plastic repair of cheek
+∞
7.4
7
*
QAE30
NOMESCO Finland
Excision and repair of surgical scar in head or neck
+∞
7.4
7
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
+∞
7.4
7
*
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
32.1
7.3
9
*
SPD00
NOMESCO Finland
Fitting and preparation of total teeth prosthesis
32.1
7.3
9
*
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
10.2
7.0
13
14
WX002
NOMESCO Finland
Sedation and analgesia
3.4
6.9
37
138
ECB20
NOMESCO Finland
Oral alveoplasty
17.9
6.9
10
6
J01CE02
ATC
phenoxymethylpenicillin; oral
2.9
6.8
91
605
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
6.9
6.7
16
26
SXC05
NOMESCO Finland
Other oral or dental procedure
7.3
6.6
15
23
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
73.5
6.5
7
*
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
73.5
6.5
7
*
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
4.6
6.4
22
56
RD210
NOMESCO Finland
NA
19.2
6.4
9
5
ZXA05
NOMESCO Finland
Left side
2.9
6.3
44
197
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
28.3
6.3
8
*
K08.0
ICD-10 Finland
Exfoliation of teeth due to systemic causes
+∞
6.3
6
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
6.3
6
*
EEW99
NOMESCO Finland
Other operation on maxilla
+∞
6.3
6
*
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
+∞
6.3
6
*
EEA10
NOMESCO Finland
Biopsy of maxilla
+∞
6.3
6
*
EHB00
NOMESCO Finland
Excision of lesion of palate
+∞
6.3
6
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
6.3
6
*
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
+∞
6.3
6
*
L43.0
ICD-10 Finland
Hypertrophic lichen planus
+∞
6.3
6
*
EB1JA
NOMESCO Finland
Double panorama tomography of teeth and jaws or similar X-ray examination
+∞
6.3
6
*
L03AA02
ATC
filgrastim; parenteral
+∞
6.3
6
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
7.4
6.2
14
21
SDA02
NOMESCO Finland
Parodonthologic therapy
2.8
6.2
49
236

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_GUM_EXALLC – Malignant neoplasm of gum, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).