Marginal zone B-cell lymphoma, excluding all cancers (controls excluding all cancers)

C3_MARGINAL_ZONE_LYMPHOMA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C83.80, C83.89
  • Cause of death: ICD-10 C83.80, C83.89
  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 9699
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

532

4. Check minimum number of events

None

532

5. Include endpoints

None

532

6. Filter based on genotype QC (FinnGen only)

532

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 532 263 269
Unadjusted period prevalence (%) 0.10 0.09 0.12
Median age at first event (years) 64.89 63.61 66.13

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
265
Matched controls
2650
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
+∞
285.9
220
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
578.5
113.7
105
*
XW000
NOMESCO Finland
Bone marrow biopsy
55.1
89.1
105
31
JN4BD
NOMESCO Finland
Extensive body CT
26.5
82.5
120
80
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
904.7
72.7
68
*
WF002
NOMESCO Finland
Radical radiotherapy
308.9
71.0
69
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
608.6
52.3
50
*
A03FA01
ATC
metoclopramide; systemic, rectal
10.4
49.5
110
169
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
44.0
41
*
JN4AD
NOMESCO Finland
Body CT examination
23.4
42.7
62
34
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
48.1
42.5
51
13
A04AA02
ATC
granisetron; systemic, transdermal
+∞
41.8
39
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
32.0
39.4
52
20
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
38.5
36
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
+∞
38.5
36
*
JN6AD
NOMESCO Finland
CT of torso and neck
82.6
38.2
42
6
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
151.6
37.8
39
*
9699/3-C16.9
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of stomach, NOS
+∞
37.4
35
*
H02AB02
ATC
dexamethasone; systemic
56.6
36.9
43
9
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
410.0
36.9
36
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.8
36.6
137
412
L03AA13
ATC
pegfilgrastim; parenteral
+∞
35.2
33
*
9699/3-C77.9
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of lymph node, NOS
+∞
34.1
32
*
L03AA02
ATC
filgrastim; parenteral
+∞
34.1
32
*
XX3DW
NOMESCO Finland
Time consuming IT work
13.3
33.1
60
57
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
187.5
32.5
33
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
30.8
29
*
C85.7
ICD-10 Finland
Other specified types of non-Hodgkin lymphoma
+∞
29.7
28
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
12.7
28.9
53
51
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
+∞
28.7
27
*
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
+∞
28.7
27
*
C83.89
ICD-10 Finland
Other types of diffuse non-Hodgkin's lymphoma
+∞
25.4
24
*
A04AA01
ATC
ondansetron; systemic, rectal
17.2
25.2
40
27
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
23.3
22
*
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
+∞
22.2
21
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
22.2
21
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
21.1
20
*
PJA10
NOMESCO Finland
Exploration of lymph nodes
119.4
20.9
22
*
M04AA01
ATC
allopurinol; systemic
4.9
20.2
74
194
ZX120
NOMESCO Finland
Intravenous
6.7
20.2
54
97
9699/3-C42.1
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of bone marrow
+∞
20.0
19
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
20.0
19
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
20.2
19.6
29
16
9699/3-C77.8
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of lymph nodes of multiple regions
+∞
19.0
18
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
19.0
18
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
41.7
18.9
23
6
WW500
NOMESCO Finland
Blood transfusion
15.9
18.6
30
21
1XC02
NOMESCO Finland
NA
47.7
18.5
22
5
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
8.5
18.0
40
54
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
17.9
17
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
17.9
17
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
192.2
17.7
18
*
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
67.9
17.0
19
*
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
67.9
17.0
19
*
C83.8
ICD-10 Finland
Other non-follicular lymphoma
+∞
16.8
16
*
9699/3-C34.9
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of lung, NOS
+∞
16.8
16
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
16.8
16
*
C82.9
ICD-10 Finland
Follicular lymphoma, unspecified
+∞
15.8
15
*
9699/3-C69.6
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of orbit, NOS
+∞
15.8
15
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
15.8
15
*
PJA12
NOMESCO Finland
Sentinel node biopsy
169.5
15.6
16
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.1
15.2
114
523
C83.39
ICD-10 Finland
Diffuse non-Hodgkin's large cell lymphoma UNS
+∞
14.7
14
*
130
Kela drug reimbursment
Malignant tumour
+∞
14.7
14
*
9699/3-C07.9
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of parotid gland
+∞
14.7
14
*
C83.00
ICD-10 Finland
Lymphocytic lymphoma
+∞
14.7
14
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.8
14.6
51
124
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
38.4
14.6
18
5
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.7
14.4
52
131
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
14.3
90
363
Z51.5
ICD-10 Finland
Palliative care
12.4
14.1
25
22
ZX112
NOMESCO Finland
Subcutaneous
32.0
14.1
18
6
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
79.3
13.7
15
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
79.3
13.7
15
*
CAA30
NOMESCO Finland
Biopsy of orbit
+∞
13.7
13
*
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
11.9
13.3
24
22
WZC30
NOMESCO Finland
Teaching
4.5
13.2
49
127
R50.9
ICD-10 Finland
Fever, unspecified
4.0
13.0
56
167
CFA20
NOMESCO Finland
Biopsy of conjunctiva
52.7
13.0
15
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.9
12.9
58
179
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
12.6
12
*
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
136.1
12.5
13
*
A02BC02
ATC
pantoprazole; systemic
2.7
12.4
195
1342
JN4CD
NOMESCO Finland
Very extensive body CT
13.3
12.3
21
17
H02AB06
ATC
prednisolone; systemic
2.6
12.1
149
885
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
12.1
142
824
9699/3-C69.0
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of conjunctiva
+∞
11.5
11
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
11.5
11
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
11.5
11
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
11.5
11
*
HA1AA
NOMESCO Finland
X-ray mammography
8.4
11.1
24
31
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
14.7
11.1
18
13
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
22.6
10.8
15
7
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
6.4
10.8
28
48
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
9.8
10.7
21
23
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.4
10.5
119
661
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
114.3
10.5
11
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
16.9
10.5
16
10
115
Kela drug reimbursment
Breast cancer
+∞
10.5
10
*
C82.1
ICD-10 Finland
Follicular lymphoma grade II
+∞
10.5
10
*
9680/3-C77.9
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of lymph node, NOS
+∞
10.5
10
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
13.0
9.5
16
13
HA1AT
NOMESCO Finland
Biopsy of mammary glands with ultrasound guidance
103.5
9.5
10
*
116
Kela drug reimbursment
Prostate cancer
+∞
9.4
9
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.1
9.0
35
95
N02AA05
ATC
oxycodone; systemic
3.3
8.7
45
154
WX402
NOMESCO Finland
General anaesthesia
3.2
8.7
48
171
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
92.8
8.5
9
*
D31.6
ICD-10 Finland
Benign neoplasm: Orbit, unspecified
92.8
8.5
9
*
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
92.8
8.5
9
*
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
92.8
8.5
9
*
TGE00
NOMESCO Finland
Needle biopsy of mediastinum
92.8
8.5
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
8.4
66
295
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
9.9
8.4
16
17
9699/3-C08.0
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of submandibular gland
+∞
8.4
8
*
L01AA02
ATC
chlorambucil; oral
+∞
8.4
8
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
8.4
8
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
8.4
8
*
9699/3-C80.9
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of unknown primary site
+∞
8.4
8
*
9699/3-C44.9
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of skin, NOS
+∞
8.4
8
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
8.4
8
*
C82.01
ICD-10 Finland
Follicular nodular lymphoma, grade I
+∞
8.4
8
*
1AA09
NOMESCO Finland
NA
+∞
8.4
8
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
8.4
8
*
C88.4
ICD-10 Finland
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lyphoma]
+∞
8.4
8
*
H02AB07
ATC
prednisone; oral
2.9
8.3
52
203
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.8
8.3
57
236
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.4
8.2
40
131
GD1AD
NOMESCO Finland
Thorax CT examination
5.3
8.1
24
49
WX002
NOMESCO Finland
Sedation and analgesia
2.5
7.8
67
313
CBA10
NOMESCO Finland
Biopsy of eyelid
15.6
7.8
12
8
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
15.6
7.8
12
8
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.2
7.8
29
76
ZXA05
NOMESCO Finland
Left side
2.3
7.7
81
422
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
9.8
7.4
14
15
ZX013
NOMESCO Finland
Radiotherapy with large shaped fields - SSD therapy
+∞
7.3
7
*
C83.01
ICD-10 Finland
Lymphoplasmacytic lymphoma
+∞
7.3
7
*
GDC01
NOMESCO Finland
Thoracoscopic lobectomy of lung
+∞
7.3
7
*
ED1AA
NOMESCO Finland
Mandipular X-ray examination
30.9
7.2
9
*
D70.89
ICD-10 Finland
Neutropenic splenomegaly
30.9
7.2
9
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
12.5
7.1
12
10
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.7
6.9
13
14
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
5.2
6.8
20
41
D37.00
ICD-10 Finland
Aryepiglottic fold marginal zone
41.1
6.8
8
*
EL4AT
NOMESCO Finland
Salivary gland cytology with ultrasound guidance
41.1
6.8
8
*
WX110
NOMESCO Finland
Local anesthesy
2.0
6.7
173
1287
D47.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
71.4
6.5
7
*
XW3AT
NOMESCO Finland
Biopsy of other superficial organ with ultrasound guidance
71.4
6.5
7
*
J05AB11
ATC
valaciclovir; oral
2.8
6.4
41
162
B01AB05
ATC
enoxaparin; parenteral
2.1
6.4
86
492
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
18.5
6.3
9
5
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
6.3
6
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
6.3
6
*
C83.1
ICD-10 Finland
Mantle cell lymphoma
+∞
6.3
6
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
6.3
6
*
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
+∞
6.3
6
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
6.3
6
*
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
+∞
6.3
6
*
ELB00
NOMESCO Finland
Excision or exploration of lesion of salivary gland
+∞
6.3
6
*
C83.3
ICD-10 Finland
Diffuse large B-cell lymphoma
+∞
6.3
6
*
A04AD12
ATC
aprepitant; systemic
+∞
6.3
6
*
EL3AE
NOMESCO Finland
Salivary gland ultrasound examination
27.4
6.3
8
*
ZX108
NOMESCO Finland
Inhalation
27.4
6.3
8
*
UJF32
NOMESCO Finland
Coloscopy
2.1
6.3
77
425
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
8.0
6.2
13
17
B01AB10
ATC
tinzaparin; parenteral
4.5
6.1
20
47
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.4
6.1
28
89

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
230
128
30.89
304.92
2.2
1.2
—
—
—
0
0
246
212
20.72
260.31
1.3
1.3
—
—
—
0
0
140
30
62.98
246.56
1.7
1.0
—
—
—
0
0
118
13
116.36
230.36
1.5
1.0
—
—
—
0
0
269
344
14.80
218.35
1.5
1.4
—
—
—
0
0
275
379
13.95
210.76
1.5
1.5
—
—
—
0
0
292
464
12.73
199.65
1.6
1.6
—
—
—
0
0
99
23
52.66
169.59
3.3
1.8
1.2
1.1
e9/l
0.11
69
13
216
289
11.90
165.31
4.0
2.2
9.2
10.8
g/l
3.49
207
266
116
55
26.69
159.66
1.9
1.8
—
—
—
0
0
80
19
49.38
135.68
2.6
1.9
14.8
11.3
%
—
29
9
68
11
70.73
124.14
3.5
1.4
0.3
0.2
e9/l
0.41
68
11
170
237
10.07
123.28
3.1
1.3
2.8
1.1
g/l
3.07
163
216
380
1331
7.49
110.29
10.1
5.5
—
—
—
0
0
176
309
8.02
103.44
2.4
1.4
—
—
—
0
0
347
1186
6.54
101.07
4.1
2.4
884.3
7237.2
umol/l
3.68
339
1009
432
1821
8.30
98.86
11.4
5.3
0.7
0.7
%
0.14
421
1690
436
1871
8.37
97.26
11.7
5.4
2.8
3.0
%
0.87
426
1733
435
1875
8.24
96.13
12.3
5.6
9.7
8.7
%
7.02
425
1745
449
2023
8.82
93.56
10.6
5.1
0.6
0.6
e9/l
0.02
412
1751
435
1905
8.04
93.43
11.9
5.5
28.6
27.2
%
1.26
424
1765
450
2037
8.84
93.12
10.6
5.2
0.0
0.0
e9/l
2.24
414
1769
452
2067
8.89
92.07
10.7
5.2
2.0
1.8
e9/l
0.44
424
1820
429
1891
7.55
90.25
11.0
5.3
55.7
57.6
%
2.03
416
1760
453
2108
8.74
89.45
11.1
5.3
0.2
0.2
e9/l
1.75
420
1855
442
2069
7.72
84.72
13.4
3.7
10.7
11.7
umol/l
1.90
435
1937
459
2238
8.66
83.62
22.0
6.2
3.4
4.3
e9/l
19.77
432
1959
52
16
35.91
81.67
4.1
1.7
553.5
1279.7
e6/l
—
27
6
170
389
5.95
74.56
4.3
2.4
74.6
68.8
e9/l
0.87
148
308
196
512
5.48
73.96
4.4
2.2
1.9
1.8
%
0.67
185
459
161
354
6.09
73.66
2.6
1.6
66.0
67.8
g/l
1.59
150
316
50
21
26.18
70.76
4.4
2.4
29.6
46.7
%
—
26
8
389
1812
5.27
69.27
7.5
3.5
35.1
35.5
g/l
0.86
374
1676
146
314
6.03
67.98
6.6
3.9
0.6
0.8
%
0.30
73
65
73
77
10.83
63.62
1.3
1.4
—
—
—
0
0
92
133
8.15
62.62
2.1
1.4
23.1
31.5
mg/l
1.71
82
108
92
133
8.15
62.62
2.2
1.4
51.0
42.7
mg/l
0.38
80
109
135
291
5.88
62.34
6.5
3.9
0.5
0.5
%
0.08
53
53
197
599
4.63
60.19
5.9
2.6
0.8
0.8
mmol/l
1.36
191
549
62
59
11.76
57.85
1.5
1.3
—
—
—
0
0
131
299
5.49
56.41
7.0
4.0
0.1
0.1
%
0.37
67
57
76
100
8.70
55.79
2.1
1.4
—
—
—
0
0
402
2133
4.62
54.79
9.8
5.4
1.2
1.2
mmol/l
0.84
339
1815
300
1303
3.99
54.68
2.6
1.6
—
—
—
0
0
57
56
11.28
51.95
1.5
1.4
107.2
109.2
u/ml
—
20
6
88
160
6.39
47.94
2.7
1.4
10.3
10.5
g/l
0.07
76
131
119
286
5.07
47.77
6.7
4.1
0.0
1.6
%
0.49
57
54
366
1951
3.81
46.28
8.3
5.0
1.2
1.2
mmol/l
1.37
358
1730
52
56
10.18
44.31
2.9
2.1
33.9
33.2
pg
0.42
52
56
49
7
76.77
43.82
2.6
1.6
8.6
3.1
%
—
49
7
49
7
76.77
43.82
2.6
1.6
—
—
—
0
0
45
41
11.90
42.96
5.7
3.3
1.0
1.1
%
0.05
37
32
201
762
3.63
42.91
2.2
1.3
1.9
2.8
g/l
6.06
158
438
253
1111
3.44
42.72
7.6
3.9
—
—
—
0
0
288
1379
3.37
41.98
6.0
2.0
2.4
2.4
mmol/l
0.10
269
1131
268
1246
3.32
40.71
7.3
3.2
7.4
7.4
ph
0.15
72
218
477
3245
5.55
38.23
18.6
5.3
80.5
75.7
u/l
2.20
471
2969
111
300
4.41
37.99
1.5
1.1
—
—
—
0
0
327
1816
3.08
34.74
18.7
8.6
0.0
0.0
e9/l
0.11
290
1501
204
874
3.16
34.45
8.7
4.1
—
—
—
0
0
203
907
3.00
31.32
16.0
4.7
—
—
—
0
0
32
29
11.68
30.49
7.0
3.3
48.7
47.6
%
0.06
21
21
37
42
9.39
30.14
1.1
1.1
—
—
—
0
0
462
3274
4.12
30.05
7.9
4.2
17.4
12.5
mm/h
5.92
448
2985
34
35
10.31
29.73
6.8
3.7
—
—
—
0
0
317
1842
2.78
29.03
6.1
3.5
—
—
—
0
0
86
239
4.10
27.95
2.3
1.4
3.0
4.0
ug/l
0.34
61
186
34
9
40.23
27.42
1.5
1.0
—
—
—
0
0
306
1784
2.68
27.23
7.8
9.7
1.1
1.3
inr
8.22
93
525
200
969
2.70
25.54
5.4
3.4
86.0
87.3
%
0.32
190
939
228
1201
2.57
24.29
4.1
2.0
—
—
—
0
0
38
58
6.98
24.15
1.2
1.2
268.0
286.7
u/ml
0.11
23
34
36
57
6.70
22.09
2.0
2.4
—
—
—
0
0
68
188
4.00
22.09
4.2
1.7
1.4
1.5
g/l
0.16
57
166
146
643
2.75
22.04
2.8
1.8
29.9
29.5
s
0.34
139
623
135
580
2.78
21.31
2.4
2.3
2.2
2.3
g/l
0.92
125
537
185
932
2.51
21.09
3.7
2.0
—
—
—
0
0
128
543
2.79
20.64
2.5
2.4
23.4
23.7
%
0.04
111
463
35
61
6.07
19.55
1.3
1.3
144.2
273.0
miu/ml
—
8
23
28
39
7.52
19.25
1.4
1.2
—
—
—
0
0
24
28
8.93
19.03
2.3
2.3
—
—
—
0
0
24
28
8.93
19.03
1.1
1.1
—
—
—
0
0
41
86
5.08
18.79
1.3
1.2
—
—
—
0
0
137
636
2.55
18.23
2.6
2.3
13.1
13.4
umol/l
0.13
129
583
365
2574
2.33
18.06
5.7
4.4
6.6
6.8
mmol/l
1.66
355
2400
103
428
2.74
17.04
3.9
2.3
5.8
6.9
umol/l
0.82
95
372
212
1248
2.16
15.90
3.8
3.0
39.2
105.6
e6/l
0.64
164
953
237
1474
2.10
15.23
4.5
3.5
55.3
91.6
e6/l
0.92
168
1032
192
1103
2.16
15.19
3.7
2.9
—
—
—
0
0
32
65
5.17
15.18
1.1
1.1
—
—
—
0
0
84
333
2.81
15.11
1.8
1.8
0.2
0.2
g/l
0.97
74
294
14
10
14.35
15.09
1.2
1.0
—
—
—
0
0
196
1149
2.12
14.60
3.7
3.0
0.3
0.4
e6/l
1.23
144
853
188
1100
2.10
13.96
2.4
2.2
3.1
3.0
mg/l
0.22
169
927
25
45
5.78
13.48
1.5
1.3
7.0
6.3
g/l
0.18
17
31
25
45
5.78
13.48
1.5
1.3
0.3
0.3
g/l
0.10
17
31
25
45
5.78
13.48
1.6
1.3
—
—
—
0
0
25
45
5.78
13.48
1.5
1.3
1.9
2.6
g/l
0.88
18
31
30
64
4.91
13.46
1.7
1.7
0.4
0.8
g/l
1.22
21
49
121
603
2.30
13.37
2.0
1.9
—
—
—
0
0
23
39
6.12
13.16
1.1
1.3
—
—
—
0
0
127
652
2.25
13.04
3.0
2.8
2.1
2.1
e6/l
0.02
68
344
28
58
5.04
12.99
1.1
1.0
—
—
—
0
0
36
93
4.08
12.74
1.9
1.7
44.3
142.0
u/ml
0.54
31
72
262
1784
1.92
12.22
2.6
2.2
80.5
78.3
nmol/l
0.51
245
1541
31
75
4.33
11.95
4.9
3.3
56.4
58.9
%
0.36
31
75
365
2788
1.98
11.91
5.6
4.3
2356.1
3471.7
e6/l
—
7
41
381
2956
2.02
11.86
5.2
4.2
—
—
—
0
0
143
797
2.09
11.79
3.2
2.5
516.6
546.5
mosm/kgh2o
1.00
128
668
75
331
2.47
10.76
6.3
7.3
—
—
—
0
0
149
869
1.99
10.72
3.2
2.3
5.0
5.3
e6/l
0.16
134
756
152
895
1.98
10.63
3.4
4.1
269.2
364.0
ng/l
0.19
124
731
16
23
7.14
10.62
2.3
1.1
—
—
—
0
0
251
1740
1.84
10.59
3.4
2.6
283.4
131.3
ug/l
3.81
235
1572
29
74
4.09
10.44
4.4
3.0
3.2
4.5
e9/l
3.75
29
74
166
1016
1.92
10.31
1.6
1.3
—
—
—
0
0
12
13
9.42
9.90
1.3
1.0
—
—
—
0
0
113
614
2.07
9.80
1.8
1.2
—
—
—
0
0
91
459
2.19
9.56
5.8
3.5
—
—
—
0
0
15
23
6.68
9.40
1.3
2.1
—
—
—
0
0
20
41
5.03
9.38
1.4
1.4
—
—
—
0
0
20
41
5.03
9.38
1.4
1.4
—
—
—
0
0
20
41
5.03
9.38
1.4
1.4
—
—
—
0
0
20
41
5.03
9.38
1.4
1.4
—
—
—
0
0
15
24
6.40
9.03
2.1
2.8
3407.3
1372.7
u/ml
0.81
15
24
481
4262
2.34
7.98
34.7
13.0
21.7
23.7
mg/l
0.62
453
3307
38
139
2.87
7.88
2.4
1.8
—
—
—
0
0
190
1298
1.72
7.83
4.0
3.1
—
—
—
0
0
15
29
5.29
7.49
2.3
1.1
—
—
—
0
0
16
33
4.97
7.45
1.3
1.1
—
—
—
0
0
57
262
2.32
7.44
3.2
2.8
3.8
3.9
e9/l
0.06
44
185
49
216
2.40
7.03
5.3
9.3
—
—
—
0
0
142
919
1.74
6.98
1.8
1.6
1.6
1.2
mg/l
1.03
114
705
37
144
2.69
6.85
2.5
2.7
0.9
0.3
g/l
0.62
20
45
10
6
16.95
6.76
3.2
1.0
—
—
—
0
0
22
64
3.54
6.63
1.0
1.1
—
—
—
0
0
34
130
2.73
6.52
1.4
1.2
2.2
3.1
u/ml
0.47
11
18
96
570
1.83
6.25
1.3
1.3
1012.9
586.2
titre
0.88
28
139
14
30
4.77
6.24
1.6
1.1
13766.7
21613.7
e6/l
—
6
16
11
19
5.89
6.13
1.3
2.1
1.9
3.3
nmol/l
0.87
11
19
15
35
4.38
6.06
1.5
1.1
1167.4
2549.7
e6/l
—
8
23
190
1375
1.59
5.91
2.8
2.1
56.4
57.0
u/l
0.08
174
1254
49
234
2.21
5.86
4.6
7.9
25.5
25.1
mmol/l
0.24
49
234
140
945
1.65
5.76
1.9
1.8
1179.3
1205.6
nmol/l
0.12
111
711
80
465
1.85
5.56
5.2
6.4
96.9
95.2
%
2.87
75
451
12
25
4.89
5.52
1.4
1.2
—
—
—
0
0
86
516
1.80
5.39
5.3
6.2
13.3
11.5
kpa
2.14
81
500
86
516
1.80
5.39
5.3
6.2
5.1
5.1
kpa
0.06
81
499
367
3119
1.57
5.36
4.4
4.1
—
—
—
0
0
86
518
1.79
5.32
5.2
6.2
1.4
1.5
mmol/l
0.04
70
400
63
344
1.94
5.29
4.5
3.7
—
—
—
0
0
19
59
3.30
5.22
1.4
1.3
118.4
62.4
pmol/l
1.44
19
59
42
198
2.22
5.19
1.5
1.2
—
—
—
0
0
13
31
4.27
5.12
1.6
1.6
—
—
—
0
0
11
23
4.86
5.03
1.3
1.1
—
—
—
0
0
70
404
1.84
4.97
4.6
3.3
1.8
2.1
mmol/l
0.23
59
326
160
1156
1.55
4.85
1.7
1.5
20.3
20.9
nmol/l
0.19
146
965
35
158
2.30
4.80
1.5
1.2
—
—
—
0
0
12
29
4.21
4.65
1.1
1.4
—
—
—
0
0
23
87
2.72
4.55
1.6
1.1
—
—
—
0
0
78
479
1.74
4.50
1.8
1.7
—
—
—
0
0
246
1971
1.46
4.42
2.3
2.0
92.7
95.0
pmol/l
0.30
148
992
193
1475
1.48
4.41
2.9
3.0
1652.4
1371.8
ng/l
0.42
169
1246
11
26
4.30
4.37
1.1
1.2
—
—
—
0
0
24
96
2.57
4.27
3.4
2.3
1.7
1.7
mg/l
0.18
24
85
68
413
1.74
4.08
2.1
3.2
306.0
196.9
ng/l
0.71
63
385
256
2090
1.43
4.05
3.8
3.6
0.0
0.0
estimate
0.00
70
368
18
64
2.88
3.99
1.0
1.1
—
—
—
0
0
16
54
3.02
3.88
1.5
1.5
—
—
—
0
0
10
25
4.06
3.71
1.5
1.3
22.5
15.1
ug/l
—
10
25
256
2113
1.41
3.70
4.0
3.6
0.0
0.0
estimate
0.50
70
357
18
68
2.70
3.60
2.1
2.9
—
—
—
0
0
51
296
1.80
3.58
5.8
3.6
7.4
7.4
ph
—
7
36
7
9
7.86
3.57
1.0
1.1
—
—
—
0
0
7
9
7.86
3.57
1.1
1.0
—
—
—
0
0
252
2084
1.40
3.55
5.3
4.9
0.0
0.0
estimate
0.00
68
357
36
187
1.99
3.53
1.6
1.5
—
—
—
0
0
8
13
6.23
3.51
2.1
1.0
—
—
—
0
0
78
514
1.61
3.45
1.9
1.5
—
—
—
0
0
40
220
1.88
3.33
5.1
3.6
—
—
—
0
0
30
149
2.07
3.32
1.6
1.5
—
—
—
0
0
52
314
1.73
3.21
3.9
4.4
—
—
—
0
0
7
11
6.43
3.19
2.4
2.2
—
—
—
0
0
387
4212
0.70
3.16
5.7
6.5
39.8
40.6
mmol/mol
0.89
350
3880
57
355
1.68
3.15
1.7
1.5
—
—
—
0
0
33
175
1.94
3.07
2.0
2.2
138.0
579.6
ug/l
1.03
33
161
6
9
6.73
2.87
1.7
1.4
—
—
—
0
0
413
3778
1.42
2.83
32.2
14.1
37.6
39.8
%
4.00
273
2446
65
439
1.55
2.61
1.4
1.3
—
—
—
0
0
5
7
7.20
2.55
1.6
1.4
—
—
—
0
0
6
11
5.50
2.55
1.5
1.5
—
—
—
0
0
20
95
2.15
2.52
4.1
2.1
117.3
133.5
g/l
1.92
11
71
18
82
2.24
2.50
4.9
2.6
—
—
—
0
0
8
21
3.85
2.47
1.0
1.0
—
—
—
0
0
48
307
1.62
2.43
1.3
1.2
—
—
—
0
0
6
12
5.04
2.41
1.0
1.9
—
—
—
0
0
5
8
6.30
2.37
1.6
1.7
—
—
—
0
0
7
17
4.16
2.36
1.0
1.1
—
—
—
0
0
7
17
4.16
2.36
1.0
1.1
—
—
—
0
0
7
17
4.16
2.36
1.0
1.1
—
—
—
0
0
217
1838
1.31
2.33
3.8
3.8
21.4
40.3
ng/l
4.77
168
1348
53
352
1.56
2.30
5.2
3.7
94.3
83.3
ng/l
0.39
48
309
21
106
2.02
2.28
2.7
3.3
—
—
—
0
0
198
1667
1.30
2.20
3.3
3.4
—
—
—
0
0
116
1448
0.75
2.08
2.7
3.1
—
—
—
0
0
112
876
1.35
2.07
1.3
1.3
4.1
1.7
u/ml
0.51
24
236
10
38
2.66
2.02
1.1
1.1
—
—
—
0
0
360
3293
1.29
2.00
3.9
3.8
14.8
15.0
pmol/l
0.89
331
2941
21
113
1.89
1.94
1.5
1.4
259.5
309.0
ug/g
0.61
16
66
8
27
2.99
1.94
1.0
1.1
—
—
—
0
0
97
750
1.36
1.93
1.3
1.3
64.4
37.2
iu/ml
0.89
36
229
6
17
3.56
1.84
1.2
1.1
—
—
—
0
0
30
471
0.62
1.84
1.4
1.6
—
—
—
0
0
11
47
2.37
1.78
1.2
1.1
—
—
—
0
0
170
1437
1.27
1.77
4.3
4.0
—
—
—
0
0
16
81
2.01
1.76
1.1
1.7
—
—
—
0
0
6
18
3.36
1.75
1.2
1.1
—
—
—
0
0
18
96
1.91
1.72
1.2
1.2
—
—
—
0
0
40
273
1.50
1.59
1.4
1.3
—
—
—
0
0
27
168
1.64
1.58
1.9
1.9
—
—
—
0
0
16
85
1.91
1.56
5.1
3.9
—
—
—
0
0
8
33
2.45
1.54
1.0
1.1
—
—
—
0
0
140
1648
0.80
1.53
4.1
4.0
12.8
7.8
mg/mmol
0.35
88
1045
11
51
2.18
1.51
1.1
1.3
—
—
—
0
0
9
38
2.39
1.46
1.2
1.1
—
—
—
0
0
418
4380
0.79
1.44
4.1
4.8
1.4
1.5
mmol/l
3.96
372
3985
6
22
2.75
1.44
1.0
1.3
—
—
—
0
0
432
4507
0.78
1.41
4.7
5.5
2.6
2.7
mmol/l
1.44
385
4110
423
4420
0.79
1.36
4.2
4.9
4.4
4.6
mmol/l
1.67
378
4046
39
275
1.45
1.35
1.4
1.3
—
42.7
—
0
15
467
4490
1.33
1.35
26.8
12.5
—
—
—
0
0
9
42
2.16
1.34
1.7
1.5
274.4
269.8
mosm/kgh2o
—
9
26
135
1151
1.23
1.27
4.4
3.9
0.0
0.0
estimate
0.50
69
354
9
44
2.06
1.27
1.2
1.1
—
—
—
0
0
9
44
2.06
1.27
1.2
1.1
—
—
—
0
0
16
92
1.76
1.26
2.8
4.6
5.1
5.1
kpa
0.07
16
92
13
70
1.88
1.25
2.1
1.7
341.5
274.6
mu/l
0.35
13
64
121
1024
1.24
1.22
3.7
3.6
—
—
—
0
0
16
93
1.74
1.22
2.8
4.6
8.6
8.2
kpa
0.35
16
93
16
93
1.74
1.22
5.0
2.8
14.2
16.2
%
—
9
44
16
262
0.60
1.22
1.4
1.4
—
—
—
0
0
78
628
1.28
1.20
25.0
26.3
1.2
1.3
inr
0.30
12
96
16
94
1.72
1.18
3.8
3.0
—
—
—
0
0
6
130
0.46
1.17
1.3
1.6
—
—
—
0
0
7
30
2.35
1.12
2.0
2.3
—
—
—
0
0
127
1092
1.21
1.10
3.9
3.3
—
—
—
0
0
35
253
1.41
1.09
2.5
2.4
—
—
—
0
0
8
41
1.97
1.09
2.5
2.3
—
—
—
0
0
7
33
2.14
1.06
1.0
1.0
—
—
—
0
0
165
1461
1.19
1.04
2.1
2.2
211.6
269.3
u/l
0.33
154
1370
138
1568
0.84
1.01
3.5
3.3
2933.9
233.1
mg/l
1.89
95
995
7
35
2.01
1.00
1.9
1.1
—
—
—
0
0
87
728
1.23
0.99
1.2
1.3
6.5
14.8
u/ml
1.37
30
268
5
23
2.18
0.98
2.2
3.2
—
—
—
0
0
142
1605
0.84
0.98
3.3
3.1
7.3
7.5
mmol/l
0.37
119
1338
7
36
1.96
0.97
4.0
2.1
9.1
10.2
%
—
7
36
11
62
1.79
0.95
1.5
1.3
—
—
—
0
0
12
70
1.73
0.93
2.7
2.1
—
—
—
0
0
489
4783
1.28
0.80
47.5
19.0
4.3
4.5
e12/l
13.91
483
4618
37
287
1.31
0.79
3.1
2.5
—
—
—
0
0
489
4784
1.27
0.78
47.6
19.0
6.6
6.7
e9/l
0.23
483
4621
0
26
0.00
0.78
0.0
1.0
—
149.2
—
0
26
411
4248
0.86
0.76
3.7
4.3
1.3
1.3
mmol/l
0.17
364
3834
9
53
1.71
0.75
1.6
1.2
—
—
—
0
0
5
24
2.09
0.74
1.2
2.3
—
—
—
0
0
488
4780
1.25
0.72
47.8
19.0
219.9
244.6
e9/l
11.18
482
4627
415
4012
1.16
0.69
4.9
4.7
2.0
2.3
mu/l
0.51
383
3601
12
180
0.66
0.69
7.0
10.6
—
—
—
0
0
7
44
1.60
0.65
1.3
1.3
—
—
—
0
0
13
189
0.68
0.65
1.5
1.5
—
—
—
0
0
117
1051
1.15
0.62
1.6
1.8
501.7
29384327.6
pmol/l
1.26
95
844
28
218
1.30
0.61
3.3
2.3
0.5
0.2
e6/l
0.77
28
212
105
938
1.15
0.60
2.9
2.7
0.8
0.8
ug/l
0.23
71
623
0
20
0.00
0.60
0.0
2.2
—
—
—
0
0
6
35
1.72
0.58
1.0
1.5
—
—
—
0
0
30
239
1.27
0.56
1.2
1.2
150.0
110.6
iu/ml
—
9
98
16
117
1.38
0.53
1.7
1.2
—
—
—
0
0
29
234
1.25
0.50
3.6
2.7
24.7
25.3
mmol/l
0.43
29
228
33
272
1.23
0.48
2.1
2.2
13.8
15.1
nmol/l
0.33
28
236
10
68
1.48
0.47
1.4
1.5
51.8
73.1
%
—
5
45
41
349
1.19
0.45
1.4
1.5
—
—
—
0
0
8
56
1.44
0.42
1.1
1.2
—
—
—
0
0
5
33
1.52
0.41
1.0
1.1
—
5.7
—
0
7
0
16
0.00
0.41
0.0
11.1
—
942.7
—
0
16
0
16
0.00
0.41
0.0
13.1
—
1751.3
—
0
16
0
17
0.00
0.40
0.0
10.6
—
0.6
—
0
17
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
205.2
—
0
19
9
68
1.33
0.37
2.9
2.3
—
—
—
0
0
9
68
1.33
0.37
2.9
2.3
105.7
105.0
mmol/l
—
9
68
9
68
1.33
0.37
2.9
2.3
4.2
4.1
mmol/l
—
9
68
13
98
1.33
0.37
4.0
3.8
25.4
25.9
mg/l
—
8
67
447
4392
1.11
0.37
4.9
5.0
5.9
6.1
mmol/l
1.66
404
3962
34
394
0.85
0.36
4.7
3.1
—
—
—
0
0
114
1223
0.91
0.35
1.8
1.7
1.4
1.4
mmol/l
0.03
97
1003
7
52
1.35
0.31
1.0
1.0
1.7
1.5
g/l
—
7
44
7
57
1.23
0.29
1.1
1.3
—
—
—
0
0
50
451
1.12
0.28
1.8
2.2
197.5
139.3
ug/g
0.68
44
354
8
65
1.23
0.27
1.1
1.2
—
—
—
0
0
91
972
0.92
0.26
4.3
3.9
1.0
1.0
kg/l
0.11
19
141
27
235
1.16
0.26
3.0
3.4
—
—
—
0
0
9
77
1.17
0.24
1.3
1.5
—
—
—
0
0
16
134
1.20
0.23
1.1
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
6.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
6.3
—
—
—
0
0
0
14
0.00
0.20
0.0
5.6
—
24.7
—
0
14
9
113
0.79
0.20
1.0
1.1
—
—
—
0
0
6
50
1.20
0.19
1.3
1.3
—
—
—
0
0
6
53
1.13
0.18
1.2
2.5
—
—
—
0
0
26
233
1.12
0.18
1.2
1.3
—
—
—
0
0
7
62
1.13
0.17
1.1
1.3
—
—
—
0
0
8
68
1.18
0.16
1.1
1.2
—
—
—
0
0
8
69
1.16
0.16
1.1
1.2
—
—
—
0
0
8
70
1.15
0.16
1.1
1.2
—
—
—
0
0
8
70
1.15
0.16
1.1
1.2
—
—
—
0
0
14
121
1.16
0.15
4.0
4.5
—
—
—
0
0
18
202
0.89
0.14
4.2
4.2
—
—
—
0
0
14
156
0.89
0.10
1.1
1.1
—
—
—
0
0
171
1677
1.03
0.09
4.6
3.9
2.3
2.0
ug/l
0.83
153
1488
11
97
1.14
0.09
2.4
2.1
—
—
—
0
0
7
67
1.05
0.08
1.1
1.3
0.6
0.6
nmol/l
—
7
59
10
89
1.13
0.07
2.0
1.6
—
—
—
0
0
11
99
1.11
0.06
1.2
1.6
—
—
—
0
0
49
474
1.04
0.06
1.9
2.4
4.2
7.0
ug/l
1.54
42
410
10
102
0.98
0.00
1.8
1.9
44.5
42.6
nmol/l
—
10
96
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
6.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_MARGINAL_ZONE_LYMPHOMA_EXALLC – Marginal zone B-cell lymphoma, excluding all cancers (controls excluding all cancers)

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).