brain disease: A disease affecting the brain or part of the brain.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
369 |
4. Check minimum number of eventsNone |
369 |
5. Include endpointsNone |
369 |
6. Filter based on genotype QC (FinnGen only) |
359 |
Control definitions (FinnGen only)
- Control exclude
- G6_OTHNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of brain, other and unspecified
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4808 | 2024 | 2697 |
| Only index persons | 2930 | 1376 | 1554 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.06 | 0.08 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 48.81 | 47.92 | 49.20 |
| Only index persons | 41.61 | 43.17 | 40.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 359 | 158 | 201 |
| Unadjusted period prevalence (%) | 0.08 | 0.06 | 0.09 |
| Median age at first event (years) | 48.23 | 43.52 | 51.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 369
- Matched controls
- 3690
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G93.8
ICD-10 Finland
Other specified disorders of brain
+∞
77.9
72
*
G93.99
ICD-10 Finland
Disorder of brain, unspecified
+∞
75.7
70
*
34799
ICD-8 Finland
Other disease of brain, Other and unspecified
+∞
67.8
63
*
34798
ICD-8 Finland
Other disease of brain, Alii definiti
+∞
62.3
58
*
G93.90
ICD-10 Finland
Brain death
+∞
56.8
53
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
9.9
55.4
70
85
N03AX14
ATC
levetiracetam; systemic
13.3
34.6
34
28
G40.9
ICD-10 Finland
Epilepsy, unspecified
9.7
33.4
41
47
YKA02
NOMESCO Finland
Excision of kidneys from cadaver donor
+∞
27.4
26
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
11.1
25.6
28
27
3489X
ICD-9 Finland
Other conditions of brain, Unspecified condition of brain
+∞
22.1
21
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
28.5
21.7
29
11
AA1AD
NOMESCO Finland
CT of head and brain
3.0
21.4
129
555
3488X
ICD-9 Finland
Other conditions of brain
+∞
20.0
19
*
YJA10
NOMESCO Finland
Excision of liver from cadaver donor
+∞
20.0
19
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.9
18.5
26
35
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
4.3
18.3
51
132
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.1
16.6
49
132
XA800
NOMESCO Finland
Neuropsychological investigation
5.8
16.5
31
57
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
16.0
87
347
G93.9
ICD-10 Finland
Disorder of brain, unspecified
+∞
15.7
15
*
N03AF02
ATC
oxcarbazepine; oral
7.1
15.5
24
36
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.0
15.0
34
74
TAB00
NOMESCO Finland
Lumbar puncture
5.1
14.3
31
65
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.6
14.1
50
153
N03AF01
ATC
carbamazepine; oral, rectal
4.3
13.8
38
97
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
13.5
13.6
23
18
R41.0
ICD-10 Finland
Disorientation, unspecified
6.6
13.4
22
35
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
15.3
11.9
19
13
R42
ICD-10 Finland
Dizziness and giddiness
2.4
11.9
97
469
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
10.6
11.7
22
22
G93.4
ICD-10 Finland
Encephalopathy, unspecified
123.7
11.5
12
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
18.5
10.8
16
9
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
13.4
10.8
18
14
YFA50
NOMESCO Finland
Excision of heart for preparation of homograft
+∞
10.5
10
*
N05BA01
ATC
diazepam; systemic, rectal
2.6
10.0
65
281
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
4.2
10.0
27
68
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
4.7
9.9
23
51
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.7
9.7
32
93
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
8.7
9.7
20
24
N03AG01
ATC
valproic acid; systemic, rectal
3.6
9.4
32
95
183
Kela drug reimbursment
Lamotrigin and topiramate
16.1
9.1
14
9
WX730
NOMESCO Finland
Conventional respirator
19.2
9.0
13
7
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.1
9.0
38
130
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
16.8
8.6
13
8
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.1
8.6
24
62
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.6
8.5
20
45
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
+∞
8.4
8
*
H53.2
ICD-10 Finland
Diplopia
4.9
8.2
18
38
WX892
NOMESCO Finland
Monitored bed care
3.0
8.1
37
132
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
7.8
74
377
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.0
7.4
34
122
N06AB04
ATC
citalopram; systemic
2.1
7.3
83
452
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
7.3
7
*
A06AD11
ATC
lactulose; oral
2.2
7.3
68
344
N03AX09
ATC
lamotrigine; oral
3.8
7.1
22
61
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.5
7.1
46
198
N05AB03
ATC
perphenazine; systemic, rectal
4.1
7.0
19
48
N03AX18
ATC
lacosamide; systemic
17.1
6.8
10
6
78020
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Convulsions
17.1
6.8
10
6
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.2
6.6
27
90
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
6.6
68
357
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.8
6.6
20
55
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
6.4
6.5
16
26
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
71.0
6.4
7
*
L04AD02
ATC
tacrolimus; systemic
14.6
6.4
10
7
G93.1
ICD-10 Finland
Anoxic brain damage, not elsewhere classified
+∞
6.3
6
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
6.3
6
*
G93.0
ICD-10 Finland
Cerebral cysts
+∞
6.3
6
*
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
27.2
6.3
8
*
Z2445
NOMESCO Finland
Psychologist
3.7
6.2
20
57
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
6.2
55
271
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
7.9
6.2
13
17
W17
ICD-10 Finland
Other fall from one level to another
3.7
6.1
19
53
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
29
54
5.74
15.20
2.2
1.3
975.04
322.98
e6/l
0.40
23
44
29
54
5.74
15.20
2.2
1.2
25.04
2.91
e6/l
0.92
23
44
75
311
2.77
12.65
10.6
8.0
1.54
1.33
mmol/l
0.18
62
244
79
349
2.61
11.71
9.5
5.6
1.01
1.04
mmol/l
0.43
74
318
75
328
2.61
11.32
11.9
6.0
105.05
103.98
mmol/l
0.95
75
328
17
17
10.42
9.12
2.9
1.1
—
—
—
0
0
181
1231
1.92
8.64
12.1
5.7
1.19
1.21
mmol/l
3.04
169
1119
185
1298
1.85
7.75
21.0
14.2
1.33
1.29
inr
0.17
47
359
190
1347
1.85
7.68
10.7
6.5
1.20
1.21
mmol/l
1.28
161
1149
216
1627
1.79
6.84
8.4
4.5
6.95
6.73
mmol/l
0.79
208
1512
14
19
7.61
6.47
1.2
1.0
—
—
—
0
0
131
880
1.76
5.96
2.8
2.4
57.98
56.77
u/l
0.12
122
816
142
996
1.69
5.43
5.0
3.1
—
—
—
0
0
14
26
5.55
5.27
1.1
1.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
75
3.06
5.24
4.5
2.6
0.28
0.35
u/ml
0.63
17
41
5
0
+∞
5.22
3.8
0.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
12
8.53
5.09
1.2
1.1
—
—
—
0
0
100
647
1.75
5.07
3.4
2.3
—
—
—
0
0
84
520
1.80
4.94
4.0
3.5
1021.34
351.40
ng/l
0.33
67
420
14
29
4.98
4.86
1.0
1.0
—
—
—
0
0
84
525
1.78
4.77
1.9
1.6
1193.42
1150.21
nmol/l
0.14
69
400
14
31
4.65
4.60
1.0
1.0
—
—
—
0
0
35
166
2.22
4.35
1.8
1.4
—
—
—
0
0
74
458
1.77
4.32
1.9
1.8
—
—
—
0
0
8
9
9.05
4.30
1.1
1.0
—
—
—
0
0
21
79
2.76
4.23
1.5
1.4
—
—
—
0
0
7
7
10.16
4.02
1.7
1.0
—
—
—
0
0
52
295
1.89
4.01
5.8
4.1
295.62
233.93
u/l
0.50
47
280
7
238
0.28
3.89
1.7
1.8
—
—
—
0
0
89
599
1.64
3.80
2.5
1.7
2.39
1.19
mg/l
0.89
74
463
19
72
2.73
3.79
1.9
1.8
—
—
—
0
0
6
5
12.17
3.77
11.8
1.0
86.00
99.80
%
—
6
5
154
1181
1.52
3.73
8.3
4.5
33.63
35.46
g/l
3.05
142
1108
55
326
1.81
3.70
1.7
1.6
—
—
—
0
0
55
327
1.80
3.66
1.8
1.7
—
—
—
0
0
15
51
3.02
3.61
1.3
1.2
—
—
—
0
0
15
51
3.02
3.61
1.3
1.2
—
—
—
0
0
70
448
1.69
3.61
4.5
2.9
1.84
2.00
e6/l
0.10
44
251
184
1472
1.50
3.60
9.0
6.5
11.10
11.24
umol/l
0.07
177
1394
21
87
2.50
3.54
2.0
1.5
0.22
0.24
g/l
0.39
21
87
13
36
3.70
3.53
1.2
1.1
—
—
—
0
0
108
786
1.53
3.26
4.4
3.0
0.29
0.47
e6/l
0.77
90
599
7
12
5.92
3.03
1.1
1.1
—
—
—
0
0
18
75
2.47
3.02
1.6
1.6
—
—
—
0
0
46
277
1.75
2.95
3.4
3.5
—
—
—
0
0
14
52
2.76
2.92
1.2
1.6
—
—
—
0
0
10
27
3.78
2.90
1.8
1.8
—
—
—
0
0
6
9
6.75
2.88
3.0
1.6
26.00
31.11
umol/l
—
6
9
35
196
1.87
2.83
1.9
1.5
—
—
—
0
0
11
33
3.40
2.83
1.3
1.4
—
—
—
0
0
11
33
3.40
2.83
1.3
1.4
—
—
—
0
0
137
1073
1.44
2.81
4.0
3.6
41.06
41.19
ng/l
0.00
105
739
159
1283
1.42
2.75
3.7
2.6
—
—
—
0
0
13
48
2.77
2.74
1.8
1.5
—
—
—
0
0
13
48
2.77
2.74
1.8
1.5
—
—
—
0
0
8
19
4.28
2.69
2.3
2.2
—
—
—
0
0
95
700
1.48
2.65
2.7
2.0
3.50
3.21
mg/l
0.40
88
600
27
142
1.97
2.63
2.4
3.5
4.05
4.52
pmol/l
1.25
22
126
8
20
4.06
2.58
1.4
1.4
—
—
—
0
0
12
42
2.92
2.57
1.3
1.3
2.00
1.40
u/ml
—
6
15
30
166
1.88
2.53
1.4
1.7
—
—
—
0
0
34
197
1.80
2.49
8.9
3.9
103.89
85.41
ng/l
0.47
28
174
29
160
1.88
2.47
1.1
1.3
—
44.89
—
0
10
10
32
3.18
2.45
1.8
1.7
—
—
—
0
0
14
58
2.47
2.40
1.7
1.6
—
—
—
0
0
31
179
1.80
2.31
2.0
2.4
—
11.75
—
0
10
68
482
1.50
2.28
4.3
2.7
0.57
0.94
e6/l
1.64
43
283
6
13
4.67
2.28
1.8
1.5
—
—
—
0
0
6
13
4.67
2.28
1.8
1.5
—
—
—
0
0
7
18
3.94
2.26
1.0
1.0
790.43
540.00
ng/l
—
7
11
7
18
3.94
2.26
1.9
1.8
—
—
—
0
0
7
18
3.94
2.26
1.0
1.0
3884.00
252.00
ng/l
—
7
11
7
18
3.94
2.26
1.3
1.8
—
—
—
0
0
7
18
3.94
2.26
1.9
1.8
—
—
—
0
0
12
48
2.55
2.21
1.3
1.1
368.75
240.32
u/ml
0.72
12
28
188
1601
1.36
2.20
11.8
9.4
4.38
4.15
e9/l
0.61
175
1401
9
30
3.05
2.16
1.1
1.1
—
—
—
0
0
159
1327
1.35
2.10
10.0
5.9
27.41
27.54
%
0.06
149
1252
39
248
1.64
2.09
1.6
2.4
30.41
31.76
u/l
0.16
34
206
7
20
3.55
2.06
1.9
1.8
—
—
—
0
0
16
76
2.16
2.05
1.6
1.2
—
—
—
0
0
16
76
2.16
2.05
1.7
1.6
—
—
—
0
0
12
50
2.45
2.04
1.3
1.2
—
—
—
0
0
156
1306
1.34
1.99
10.2
5.7
57.57
57.51
%
0.02
147
1233
19
100
1.95
1.89
1.3
1.9
—
—
—
0
0
55
390
1.48
1.85
3.8
2.4
20.87
24.12
%
1.22
48
341
5
12
4.21
1.83
1.4
1.4
—
—
—
0
0
5
12
4.21
1.83
1.4
1.4
—
—
—
0
0
132
1091
1.33
1.81
3.2
2.2
70.93
77.19
nmol/l
2.35
120
974
11
48
2.33
1.72
1.1
1.5
—
—
—
0
0
248
2696
0.76
1.72
4.8
4.3
1.42
1.46
mmol/l
0.73
224
2492
131
1090
1.31
1.69
2.5
2.0
92.46
94.48
pmol/l
0.20
81
571
33
213
1.60
1.69
1.3
2.3
63.45
66.92
g/l
1.29
27
191
29
182
1.64
1.66
5.1
3.6
1.99
2.04
mmol/l
0.02
20
136
82
639
1.36
1.64
1.8
1.6
19.06
20.60
nmol/l
0.46
70
549
5
14
3.60
1.62
1.2
2.1
833.80
864.21
u/ml
—
5
14
15
77
1.99
1.61
1.2
3.4
—
3.64
—
0
7
8
32
2.53
1.60
1.1
1.3
0.79
0.48
nmol/l
—
8
27
293
3102
0.73
1.59
34.0
20.7
131.18
135.88
g/l
5.58
286
3051
293
3101
0.73
1.58
33.7
20.5
4.37
4.51
e12/l
4.01
280
3008
293
3098
0.74
1.53
34.0
20.6
246.34
245.72
e9/l
0.05
282
3015
293
3098
0.74
1.53
34.2
20.5
39.41
40.12
%
1.38
264
2902
258
2774
0.77
1.50
5.4
4.8
2.66
2.75
mmol/l
0.84
237
2563
241
2613
0.78
1.50
4.5
3.9
1.31
1.29
mmol/l
0.21
218
2403
9
38
2.40
1.46
1.6
1.3
—
—
—
0
0
9
38
2.40
1.46
1.1
1.6
—
—
—
0
0
12
59
2.07
1.45
1.1
1.3
—
9.96
—
0
5
25
157
1.64
1.45
1.3
1.2
47.13
142.03
iu/ml
—
6
63
5
16
3.15
1.44
1.0
1.4
—
—
—
0
0
11
53
2.11
1.40
1.7
4.2
57.09
56.21
%
0.05
11
53
6
23
2.63
1.37
1.7
1.4
—
—
—
0
0
6
23
2.63
1.37
1.3
1.2
—
—
—
0
0
25
160
1.60
1.35
1.5
1.2
753.75
242.38
u/ml
0.40
25
144
5
18
2.80
1.29
3.6
1.6
0.96
0.94
g/l
—
5
18
10
48
2.11
1.29
1.3
1.6
—
—
—
0
0
10
48
2.11
1.29
2.0
1.5
—
—
—
0
0
14
77
1.85
1.27
1.4
1.4
294.33
327.93
ug/g
—
9
39
86
702
1.29
1.25
5.0
3.8
0.00
0.00
estimate
0.50
23
233
13
70
1.89
1.25
1.7
1.4
—
—
—
0
0
12
63
1.94
1.24
1.2
1.2
—
—
—
0
0
254
2714
0.79
1.23
4.8
4.4
4.47
4.65
mmol/l
2.03
231
2529
6
26
2.33
1.19
1.0
1.0
—
—
—
0
0
10
50
2.03
1.17
1.3
3.6
4.12
4.61
e9/l
—
10
50
100
841
1.26
1.15
4.2
3.8
27.28
9.49
mg/mmol
0.87
65
549
17
103
1.68
1.15
1.9
1.9
—
—
—
0
0
18
111
1.65
1.14
2.2
2.1
—
—
—
0
0
7
30
2.36
1.13
1.0
1.5
—
—
—
0
0
5
21
2.40
1.09
1.0
1.1
—
—
—
0
0
233
2153
1.22
1.08
10.5
7.6
76.35
78.11
u/l
0.32
221
2006
243
2595
0.81
1.07
20.4
13.0
84.80
80.37
ml/min/173m2
2.48
205
2142
21
139
1.54
1.02
4.0
2.5
1.05
1.38
%
1.15
21
139
107
919
1.23
1.02
3.7
3.4
2.33
2.35
mmol/l
0.63
92
810
88
1035
0.80
1.01
4.1
4.9
1.78
2.63
ug/l
1.38
77
914
17
256
0.65
0.96
3.0
1.8
—
—
—
0
0
20
134
1.52
0.94
4.1
2.5
0.66
0.67
%
0.08
20
134
15
231
0.63
0.93
3.1
1.6
—
—
—
0
0
6
28
2.16
0.92
1.7
1.2
—
—
—
0
0
44
343
1.32
0.91
8.5
2.6
9.19
8.30
umol/l
0.11
37
301
6
29
2.09
0.89
2.3
1.6
—
—
—
0
0
6
29
2.09
0.89
2.3
1.6
—
—
—
0
0
6
29
2.09
0.89
2.3
1.6
—
—
—
0
0
8
42
1.92
0.89
1.4
1.7
—
—
—
0
0
8
43
1.88
0.88
1.9
1.5
—
—
—
0
0
8
43
1.88
0.88
1.0
1.6
—
—
—
0
0
6
30
2.02
0.87
1.2
1.2
—
—
—
0
0
41
319
1.32
0.87
10.1
6.6
—
—
—
0
0
95
819
1.22
0.87
2.4
3.1
1286.54
1558.18
ng/l
0.29
82
706
241
2554
0.84
0.86
6.5
5.7
40.72
40.03
mmol/mol
0.45
222
2377
6
31
1.95
0.84
1.7
2.0
—
—
—
0
0
67
558
1.25
0.84
1.9
1.8
446.66
414.26
pmol/l
0.40
56
481
38
294
1.33
0.84
2.5
1.8
1.57
1.52
%
0.19
32
263
13
81
1.63
0.82
1.1
1.1
—
—
—
0
0
49
599
0.79
0.79
2.9
2.9
1.03
0.76
ug/l
0.26
38
387
14
90
1.58
0.79
13.6
3.3
1.41
1.60
mg/l
0.41
14
83
13
82
1.61
0.79
1.1
1.1
—
—
—
0
0
0
26
0.00
0.78
0.0
3.1
—
59.72
—
0
26
5
24
2.10
0.75
8.2
2.3
14.56
6.04
umol/l
—
5
18
10
60
1.69
0.72
1.2
1.3
—
—
—
0
0
132
1191
1.17
0.72
3.8
2.6
124.01
144.92
ug/l
0.46
121
1103
147
1341
1.16
0.69
4.8
3.6
0.00
0.00
estimate
-0.00
29
261
7
43
1.64
0.67
1.4
1.6
—
—
—
0
0
5
28
1.80
0.66
1.4
1.1
—
—
—
0
0
5
29
1.73
0.64
5.0
5.0
—
—
—
0
0
60
511
1.21
0.63
3.6
2.8
2.45
2.45
mmol/l
0.03
51
450
14
96
1.48
0.62
2.4
1.9
—
—
—
0
0
10
63
1.60
0.62
1.0
1.1
—
—
—
0
0
196
1837
1.14
0.61
6.0
3.0
61.08
47.71
u/l
0.47
180
1729
18
131
1.39
0.60
1.2
1.4
—
—
—
0
0
232
2435
0.87
0.60
27.1
16.8
14.83
15.11
%
0.36
226
2392
285
2948
0.85
0.59
15.5
10.3
26.39
26.59
u/l
0.06
273
2839
70
609
1.18
0.59
6.1
3.7
1.02
1.02
kg/l
0.07
11
90
6
39
1.55
0.53
1.0
1.1
—
—
—
0
0
10
66
1.53
0.53
1.7
1.2
—
—
—
0
0
213
2020
1.13
0.53
4.8
3.7
14.64
14.76
pmol/l
0.29
193
1826
145
1346
1.13
0.51
6.6
4.9
0.00
0.00
estimate
-0.00
26
240
73
819
0.86
0.50
4.1
4.4
22.75
21.49
%
0.26
29
394
15
110
1.38
0.49
1.9
1.9
—
—
—
0
0
66
743
0.86
0.47
1.4
1.7
1.57
1.40
mmol/l
0.77
55
635
146
1362
1.12
0.47
4.9
3.6
0.00
0.00
estimate
-0.00
26
226
159
1685
0.90
0.43
2.7
3.0
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
8
58
1.39
0.42
1.5
1.3
—
—
—
0
0
5
33
1.52
0.41
2.8
2.0
—
—
—
0
0
5
34
1.48
0.40
2.8
1.6
—
—
—
0
0
5
35
1.43
0.39
1.6
1.5
16.07
16.06
ug/l
—
5
35
6
45
1.34
0.34
2.0
2.8
105.67
105.38
mmol/l
—
6
45
25
212
1.19
0.31
3.1
2.7
67.20
62.90
ml/min/173m2
—
10
90
42
373
1.14
0.30
1.5
1.4
—
—
—
0
0
13
102
1.28
0.30
2.2
2.7
—
—
—
0
0
41
454
0.89
0.25
1.7
1.4
—
—
—
0
0
9
74
1.22
0.25
1.0
1.3
—
—
—
0
0
6
83
0.72
0.24
1.2
1.1
—
10.97
—
0
10
65
604
1.09
0.23
1.4
1.3
1.04
1.91
u/ml
1.00
21
164
5
39
1.29
0.23
1.6
1.2
—
—
—
0
0
7
91
0.76
0.22
1.4
1.4
20.27
23.79
iu/l
—
7
73
31
345
0.89
0.21
5.2
4.3
31.35
31.37
%
0.00
23
240
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
111
1059
1.07
0.21
5.0
3.6
—
—
—
0
0
7
59
1.19
0.18
2.3
1.5
—
—
—
0
0
21
236
0.88
0.17
1.9
2.0
14.53
13.13
nmol/l
0.15
14
219
5
70
0.71
0.17
1.6
1.4
—
—
—
0
0
291
2871
1.06
0.16
26.0
16.0
3.94
3.99
mmol/l
1.95
284
2784
290
2863
1.06
0.15
27.1
15.9
139.51
139.72
mmol/l
0.56
283
2780
7
90
0.77
0.14
1.4
1.4
—
—
—
0
0
264
2670
0.96
0.10
4.4
4.5
6.03
5.98
mmol/l
0.16
242
2437
47
448
1.06
0.10
1.2
1.3
25.11
34.72
iu/ml
0.52
17
148
5
63
0.79
0.08
1.2
1.3
0.88
0.84
nmol/l
—
5
52
251
2498
1.02
0.02
5.7
4.4
2.03
1.90
mu/l
0.64
230
2257
15
142
1.06
0.02
1.0
1.0
—
—
—
0
0
280
2789
1.02
0.02
23.4
13.8
29.36
23.43
mg/l
1.58
232
2200
204
2030
1.01
0.02
5.3
3.9
12.68
12.16
mm/h
0.16
190
1864
44
434
1.02
0.00
1.2
1.3
1.32
13.44
u/ml
2.72
11
168
69
695
0.99
0.00
3.8
2.6
312.20
8279.76
umol/l
3.63
59
603
10
96
1.04
0.00
1.4
1.6
—
—
—
0
0
30
296
1.01
0.00
2.8
4.5
38.30
50.86
ug/l
0.11
23
247
0
6
0.00
0.00
0.0
2.0
—
1.19
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.2
—
7.86
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
-0.00
2.6
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
114.11
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
78
0.90
-0.00
1.3
1.4
—
—
—
0
0
5
49
1.02
-0.00
3.8
1.2
162.80
16.61
u/l
—
5
43
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_DISBROTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DISBROTHUNS | 3.99 [2.68, 5.94] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.697 |
During the follow-up period (1.1.1998 — 31.12.2019), 173 out of 487 females with G6_DISBROTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DISBROTHUNS | 4.946 [3.66, 6.68] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 227 out of 545 males with G6_DISBROTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_DISBROTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.44% | 0.838% |
| 5 | 2.171% | 5.642% |
| 10 | 6.164% | 14.249% |
| 15 | 11.626% | 26.237% |
| 20 | 20.3% | 41.219% |
Relationships between endpoints
↥Index endpoint: G6_DISBROTHUNS – Disorders of brain, other and unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data