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Disorders of brain, other and unspecified

DOID EFO Endpoint Browser PheWeb

G6_DISBROTHUNS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G93.8, G93.90, G93.99, G94.8*
  • Hospital discharge: ICD-9 — 348[8-9]
  • Hospital discharge: ICD-8 — 3479[8-9]
  • Cause of death: ICD-10 — G93.8, G93.90, G93.99, G94.8*
  • Cause of death: ICD-9 — 348[8-9]
  • Cause of death: ICD-8 — 3479[8-9]

2 out of 7 registries used, show all original rules.

351

4. Check minimum number of events

None

351

5. Include endpoints

None

351

6. Filter based on genotype QC (FinnGen only)

351

Control definitions (FinnGen only)

Control exclude
G6_OTHNEU

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4808 2024 2697
Only index persons 2930 1376 1554
Unadjusted period prevalence (%)
Whole population 0.07 0.06 0.08
Only index persons 0.06 0.05 0.06
Median age at first event (years)
Whole population 48.81 47.92 49.20
Only index persons 41.61 43.17 40.23

-FinnGen-

Key figures

All Female Male
Number of individuals 351 153 198
Unadjusted period prevalence (%) 0.07 0.05 0.09
Median age at first event (years) 47.34 42.25 51.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
323
Matched controls
3228
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G93.99
ICD-10 Finland
Disorder of brain, unspecified
+∞
69.3
64
*
G93.8
ICD-10 Finland
Other specified disorders of brain
+∞
64.8
60
*
34799
ICD-8 Finland
Other disease of brain, Other and unspecified
+∞
63.7
59
*
34798
ICD-8 Finland
Other disease of brain, Alii definiti
+∞
53.6
50
*
G93.90
ICD-10 Finland
Brain death
+∞
42.6
40
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
9.1
27.0
59
77
3489X
ICD-9 Finland
Other conditions of brain, Unspecified condition of brain
+∞
21.1
20
*
3488X
ICD-9 Finland
Other conditions of brain
+∞
20.0
19
*
YKA02
NOMESCO Finland
Excision of kidneys from cadaver donor
+∞
20.0
19
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
74.4
18.9
21
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.9
16.8
36
45
AA1AD
NOMESCO Finland
CT of head and brain
3.3
16.6
97
367
YJA10
NOMESCO Finland
Excision of liver from cadaver donor
+∞
12.6
12
*
G93.4
ICD-10 Finland
Encephalopathy, unspecified
124.2
11.5
12
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
11.3
66
243
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.6
11.2
39
93
TAB00
NOMESCO Finland
Lumbar puncture
6.9
11.1
27
42
N03AX14
ATC
levetiracetam; systemic
9.4
10.9
22
25
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
22.4
10.8
15
7
G93.9
ICD-10 Finland
Disorder of brain, unspecified
+∞
10.5
10
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
9.6
10.2
20
22
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.4
9.5
20
25
N05BA01
ATC
diazepam; systemic, rectal
2.9
9.4
58
223
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.8
9.2
39
113
R51.80
ICD-10 Finland
Headache
3.2
9.0
48
166
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
8.6
8.7
18
22
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.7
8.5
37
110
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
8.9
8.4
17
20
N03AF01
ATC
carbamazepine; oral, rectal
3.9
8.4
34
95
R42
ICD-10 Finland
Dizziness and giddiness
2.4
8.1
77
377
183
Kela drug reimbursment
Lamotrigin and topiramate
22.7
8.1
11
5
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.3
7.9
28
69
XA800
NOMESCO Finland
Neuropsychological investigation
5.0
7.8
24
51
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
12.2
7.6
13
11
N03AF02
ATC
oxcarbazepine; oral
5.8
7.5
20
36
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
+∞
7.3
7
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.9
7.2
28
76
R41.0
ICD-10 Finland
Disorientation, unspecified
5.7
7.0
19
35
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.3
6.9
33
106
WX892
NOMESCO Finland
Monitored bed care
3.2
6.8
34
113
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
6.8
92
522
N06AB04
ATC
citalopram; systemic
2.2
6.6
74
388
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.4
6.6
30
93
N03AX09
ATC
lamotrigine; oral
4.8
6.4
20
44
N05AH03
ATC
olanzapine; systemic
3.6
6.4
27
79
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
6.2
6.4
16
27
N03AG01
ATC
valproic acid; systemic, rectal
3.7
6.4
26
74
G93.1
ICD-10 Finland
Anoxic brain damage, not elsewhere classified
+∞
6.3
6
*
G93.0
ICD-10 Finland
Cerebral cysts
+∞
6.3
6
*
YFA50
NOMESCO Finland
Excision of heart for preparation of homograft
+∞
6.3
6
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.7
6.2
42
169

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
45
6.42
15.83
1.6
1.3
—
—
—
0
0
17
17
10.46
15.03
2.9
1.1
—
—
—
0
0
15
13
12.01
14.51
1.4
1.0
—
—
—
0
0
27
53
5.44
13.38
2.3
1.2
26.2
3.0
e6/l
0.93
22
43
27
53
5.44
13.38
2.3
1.3
949.4
327.4
e6/l
0.36
22
43
76
325
2.71
12.11
9.0
5.5
1.0
1.0
mmol/l
0.57
71
297
34
92
3.98
11.42
13.6
4.8
—
—
—
0
0
67
302
2.51
9.46
11.3
8.0
1.6
1.3
mmol/l
0.18
55
237
170
1171
1.88
7.66
12.0
5.7
1.2
1.2
mmol/l
2.68
156
1057
180
1282
1.83
7.12
10.6
6.5
1.2
1.2
mmol/l
1.37
153
1084
66
335
2.19
7.01
29.1
23.8
1.4
1.4
inr
—
8
43
42
174
2.61
7.00
11.8
7.1
—
—
—
0
0
113
721
1.84
6.22
5.0
4.0
—
—
—
0
0
11
19
5.94
6.14
1.7
1.2
—
—
—
0
0
88
523
1.91
6.02
3.1
2.8
539.2
572.7
mosm/kgh2o
0.74
75
451
13
27
4.96
6.02
1.5
1.3
—
—
—
0
0
125
834
1.77
5.88
2.6
2.4
57.9
56.9
u/l
0.09
116
773
201
1534
1.73
5.83
8.2
4.5
6.9
6.7
mmol/l
0.57
193
1422
26
92
2.97
5.81
1.8
3.1
0.5
0.2
g/l
1.07
20
33
125
837
1.77
5.79
8.4
5.5
—
—
—
0
0
42
202
2.23
5.06
13.5
7.3
—
—
—
0
0
112
753
1.72
4.99
4.2
2.9
—
—
—
0
0
81
496
1.82
4.97
4.0
3.5
1035.4
357.8
ng/l
0.31
64
402
142
1044
1.60
4.36
11.0
8.7
1.2
1.3
inr
0.08
35
283
18
62
3.01
4.23
1.5
1.2
—
—
—
0
0
78
496
1.74
4.17
1.9
1.7
1147.5
1149.9
nmol/l
0.01
64
380
86
567
1.68
4.02
2.5
1.7
1.6
1.2
mg/l
0.75
71
441
177
1389
1.55
4.00
8.1
6.4
11.1
11.3
umol/l
0.09
170
1314
114
810
1.60
3.96
4.2
3.1
17.8
164.2
e6/l
1.14
94
626
83
548
1.67
3.85
2.7
2.5
6.6
5.2
e6/l
0.28
75
490
6
5
12.17
3.77
5.2
4.4
—
—
—
0
0
147
1120
1.54
3.72
7.6
4.5
33.6
35.4
g/l
2.95
135
1048
9
17
5.40
3.53
1.2
1.2
—
—
—
0
0
9
254
0.34
3.47
1.1
1.3
—
—
—
0
0
20
82
2.53
3.45
2.0
1.6
0.2
0.2
g/l
0.23
20
82
125
932
1.53
3.44
5.6
3.6
34.7
88.2
e6/l
1.45
97
665
111
809
1.54
3.38
4.2
2.4
—
—
—
0
0
8
14
5.82
3.36
3.3
2.9
44.0
13.7
mu/l
—
8
14
102
731
1.56
3.34
4.3
3.0
0.3
0.4
e6/l
0.51
84
548
99
707
1.56
3.29
4.2
2.9
—
—
—
0
0
9
19
4.83
3.26
2.4
2.2
—
—
—
0
0
92
649
1.57
3.22
11.8
6.5
—
—
—
0
0
10
28
3.65
3.22
1.2
1.1
—
—
—
0
0
20
85
2.43
3.21
2.0
1.6
1.1
1.2
g/l
0.56
20
85
51
312
1.74
3.10
2.3
1.6
—
—
—
0
0
27
136
2.07
2.94
2.4
3.4
4.0
4.5
pmol/l
1.16
22
120
61
400
1.64
2.88
2.1
1.7
—
—
—
0
0
42
250
1.77
2.81
8.3
3.5
—
—
—
0
0
5
6
8.43
2.76
3.4
1.8
1.7
2.1
umol/l
—
5
6
48
300
1.70
2.71
3.5
2.5
1.6
1.8
%
0.48
37
281
90
661
1.49
2.57
2.7
2.0
3.4
3.2
mg/l
0.29
83
564
13
50
2.66
2.56
1.2
3.5
—
—
—
0
0
158
1290
1.41
2.56
8.8
5.5
0.0
0.0
e9/l
0.07
141
1131
157
1283
1.40
2.52
8.8
5.5
0.6
0.6
e9/l
0.03
141
1118
99
746
1.46
2.48
3.4
3.2
77.7
317.8
mg/l
0.96
63
495
102
774
1.45
2.46
5.9
3.7
7.4
7.4
ph
0.99
26
137
9
27
3.39
2.41
1.2
1.1
—
—
—
0
0
144
1173
1.39
2.30
9.8
5.7
0.7
0.7
%
0.04
135
1101
12
47
2.61
2.29
2.2
1.5
—
—
—
0
0
68
925
0.67
2.28
3.0
2.8
—
—
—
0
0
148
1213
1.38
2.27
9.6
5.6
2.9
2.8
%
0.14
138
1133
149
1223
1.38
2.27
9.8
5.9
8.8
8.7
%
0.25
139
1152
27
151
1.85
2.23
1.1
1.3
—
47.4
—
0
9
147
1207
1.37
2.22
5.6
4.2
—
—
—
0
0
32
190
1.75
2.19
8.6
3.8
101.3
84.5
ng/l
0.40
26
165
161
1348
1.36
2.13
9.6
5.7
0.2
0.2
e9/l
0.11
148
1197
29
169
1.78
2.11
2.0
2.5
—
12.8
—
0
9
127
1025
1.37
2.11
4.0
3.6
43.5
41.4
ng/l
0.04
97
694
231
2550
0.72
2.11
4.8
4.3
1.4
1.5
mmol/l
0.98
207
2352
8
25
3.25
2.10
1.3
1.2
—
—
—
0
0
5
10
5.05
2.07
4.8
2.1
—
—
—
0
0
56
392
1.51
2.01
2.4
2.0
—
—
—
0
0
49
334
1.54
1.98
1.6
1.3
443.6
517.1
titre
0.18
11
82
101
793
1.38
1.97
3.8
3.1
6.6
7.7
mmol/l
1.80
84
664
9
33
2.77
1.94
1.2
1.4
—
—
—
0
0
9
33
2.77
1.94
1.2
1.4
—
—
—
0
0
9
33
2.77
1.94
1.2
1.4
—
—
—
0
0
9
33
2.77
1.94
1.2
1.4
—
—
—
0
0
224
2472
0.74
1.92
4.5
3.9
1.3
1.3
mmol/l
0.40
201
2271
156
1316
1.33
1.90
8.8
5.7
1.8
1.9
e9/l
0.74
143
1181
8
28
2.90
1.87
1.1
1.3
—
—
nmol/l
—
0
0
149
1255
1.33
1.82
9.9
5.8
27.3
27.5
%
0.10
138
1173
32
201
1.65
1.82
1.3
2.3
63.4
67.0
g/l
1.30
26
179
7
23
3.08
1.81
1.1
1.1
—
—
—
0
0
241
2622
0.74
1.79
5.3
4.8
2.6
2.7
mmol/l
1.02
218
2416
175
1515
1.31
1.73
12.2
9.2
4.4
4.2
e9/l
0.74
162
1325
8
30
2.70
1.73
1.0
1.3
—
—
—
0
0
8
30
2.70
1.73
1.1
1.3
0.8
0.5
nmol/l
—
8
25
8
30
2.70
1.73
1.8
1.5
—
—
—
0
0
275
2929
0.72
1.73
33.6
20.6
131.6
135.8
g/l
4.25
268
2882
146
1234
1.31
1.72
10.2
5.6
57.8
57.6
%
0.06
137
1160
26
157
1.71
1.71
2.0
1.9
1.1
2.0
g/l
1.03
26
145
275
2928
0.72
1.71
33.3
20.6
7.2
6.7
e9/l
2.66
263
2839
275
2928
0.72
1.71
33.4
20.5
4.4
4.5
e12/l
3.21
262
2841
275
2928
0.72
1.71
33.1
20.4
30.3
30.3
pg
0.01
268
2883
23
134
1.77
1.71
10.5
11.9
—
—
—
0
0
275
2926
0.72
1.67
33.3
20.5
91.0
91.1
fl
0.02
268
2882
15
76
2.02
1.67
11.1
7.3
—
—
—
0
0
8
31
2.62
1.67
1.5
1.6
—
—
—
0
0
6
19
3.19
1.67
1.3
1.7
277.5
282.1
mosm/kgh2o
—
6
11
275
2925
0.72
1.66
33.6
20.6
246.8
246.1
e9/l
0.05
264
2849
41
281
1.52
1.64
1.8
1.5
—
—
—
0
0
23
136
1.74
1.63
2.3
2.4
—
—
—
0
0
124
1031
1.31
1.63
2.6
2.0
92.3
94.2
pmol/l
0.18
77
539
220
2409
0.77
1.58
26.6
15.0
38.7
39.8
%
0.99
130
1754
24
146
1.69
1.55
1.5
1.2
785.1
253.9
u/ml
0.39
24
130
10
44
2.31
1.54
1.2
1.1
342.6
242.0
u/ml
—
10
25
237
2567
0.76
1.54
4.7
4.3
4.4
4.6
mmol/l
2.18
214
2385
258
2761
0.75
1.52
21.8
13.2
—
—
—
0
0
74
578
1.36
1.47
5.5
3.5
—
—
—
0
0
76
601
1.34
1.40
1.8
1.6
19.1
20.6
nmol/l
0.42
64
514
97
797
1.30
1.36
4.4
3.9
28.5
10.1
mg/mmol
0.86
62
518
12
216
0.54
1.29
2.1
1.3
—
—
—
0
0
84
682
1.30
1.29
1.4
1.4
—
—
—
0
0
5
18
2.80
1.29
1.0
1.0
805.2
540.0
ng/l
—
5
11
5
18
2.80
1.29
1.0
1.0
5341.0
252.0
ng/l
—
5
11
8
35
2.31
1.27
4.3
1.9
—
—
—
0
0
81
660
1.30
1.21
5.0
3.8
0.0
0.0
estimate
0.50
21
212
26
174
1.53
1.19
1.4
1.4
—
—
—
0
0
24
158
1.56
1.18
1.5
2.2
—
—
—
0
0
222
2037
1.24
1.18
9.9
7.5
76.7
78.3
u/l
0.27
210
1894
13
72
1.84
1.16
1.2
1.2
—
—
—
0
0
0
35
0.00
1.15
0.0
1.1
—
—
—
0
0
0
35
0.00
1.15
0.0
1.1
—
—
—
0
0
82
984
0.78
1.15
4.2
4.9
1.9
2.7
ug/l
1.16
71
873
23
151
1.56
1.15
1.3
1.2
47.1
142.0
iu/ml
—
6
63
14
80
1.78
1.14
4.9
3.3
—
—
—
0
0
45
340
1.37
1.12
2.0
1.6
—
—
—
0
0
33
236
1.44
1.11
5.4
4.0
—
—
—
0
0
42
314
1.38
1.11
8.6
2.4
8.8
8.5
umol/l
0.03
35
275
30
211
1.46
1.10
6.4
3.1
—
—
—
0
0
129
1128
1.23
1.05
12.5
9.3
0.0
0.0
e9/l
0.52
110
920
11
60
1.86
1.04
3.9
4.2
—
—
—
0
0
7
34
2.08
1.03
2.7
3.2
—
—
—
0
0
5
109
0.45
1.02
3.8
1.8
—
—
—
0
0
20
131
1.56
1.02
4.0
2.5
1.0
1.4
%
1.21
20
131
47
364
1.34
1.01
3.7
2.4
21.6
23.8
%
0.61
40
316
196
1793
1.21
1.00
5.8
4.1
—
—
—
0
0
9
49
1.86
0.99
1.1
1.6
—
—
—
0
0
9
49
1.86
0.99
1.6
4.2
57.0
56.4
%
—
9
49
9
50
1.82
0.97
6.7
2.2
—
—
—
0
0
9
51
1.78
0.95
1.3
1.2
—
—
—
0
0
45
567
0.76
0.92
3.0
3.0
1.1
0.8
ug/l
0.30
35
371
100
863
1.22
0.91
3.6
3.4
2.3
2.3
mmol/l
0.60
86
752
12
72
1.69
0.86
1.4
1.4
267.4
333.2
ug/g
—
7
38
6
31
1.95
0.85
2.5
1.3
—
—
—
0
0
21
146
1.47
0.84
7.3
3.6
—
—
—
0
0
43
339
1.31
0.84
1.8
1.5
—
—
—
0
0
8
47
1.72
0.81
1.4
3.6
4.5
4.7
e9/l
—
8
47
228
2414
0.84
0.80
6.6
5.8
41.0
40.0
mmol/mol
0.65
209
2247
15
98
1.55
0.80
1.3
1.2
—
3.3
—
0
8
6
33
1.83
0.79
1.2
1.2
—
—
—
0
0
6
33
1.83
0.79
2.2
1.5
—
—
—
0
0
139
1257
1.18
0.75
4.9
3.6
0.0
0.0
estimate
0.00
26
221
5
24
2.10
0.75
1.0
1.1
—
—
—
0
0
267
2782
0.83
0.74
15.0
10.2
26.6
26.4
u/l
0.06
255
2677
124
1113
1.18
0.73
3.6
2.6
119.5
144.5
ug/l
0.59
113
1029
63
531
1.23
0.73
1.7
1.8
455.3
415.6
pmol/l
0.48
52
456
7
39
1.81
0.73
1.0
1.1
—
—
—
0
0
5
27
1.86
0.68
1.6
1.1
—
—
—
0
0
22
293
0.73
0.68
1.8
1.3
—
—
—
0
0
12
78
1.56
0.66
1.1
1.2
—
—
—
0
0
202
1894
1.16
0.66
4.8
3.8
14.7
14.8
pmol/l
0.21
182
1709
60
701
0.83
0.65
1.4
1.6
1.6
1.4
mmol/l
0.79
50
601
5
29
1.73
0.64
1.0
1.1
—
—
—
0
0
26
200
1.32
0.62
2.3
3.7
—
—
—
0
0
5
30
1.68
0.61
1.0
9.4
6.8
6.4
mmol/l
—
5
23
56
476
1.21
0.61
3.7
2.8
2.5
2.4
mmol/l
0.07
47
418
0
21
0.00
0.60
0.0
1.9
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
18
241
0.73
0.59
1.4
1.5
—
—
—
0
0
6
35
1.73
0.58
1.5
1.3
—
—
—
0
0
66
574
1.18
0.57
6.2
3.7
1.0
1.0
kg/l
0.15
11
84
9
63
1.44
0.52
4.3
1.6
—
—
—
0
0
137
1268
1.13
0.51
6.7
5.0
0.0
0.0
estimate
0.00
24
222
65
571
1.17
0.50
4.1
5.2
—
—
—
0
0
210
2201
0.89
0.50
27.4
17.2
13.9
13.7
%
0.81
204
2152
17
222
0.75
0.49
1.7
2.0
11.2
13.1
nmol/l
—
10
205
138
1283
1.12
0.48
4.9
3.6
0.0
0.0
estimate
0.00
24
207
12
85
1.43
0.47
14.2
3.3
1.4
1.6
mg/l
0.43
12
78
58
508
1.17
0.47
1.8
1.4
2.0
2.5
g/l
2.25
40
309
21
264
0.78
0.46
2.0
1.6
—
—
—
0
0
7
51
1.38
0.44
1.0
1.1
—
—
—
0
0
23
186
1.25
0.41
1.8
1.5
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
5
34
1.48
0.40
3.6
3.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.8
—
507.1
—
0
12
172
1808
0.90
0.40
4.2
3.8
—
—
—
0
0
5
35
1.43
0.39
1.2
1.2
—
—
—
0
0
5
35
1.43
0.39
1.6
1.5
16.1
16.8
ug/l
—
5
35
22
179
1.24
0.38
1.3
1.4
—
—
—
0
0
5
37
1.36
0.37
2.6
1.8
—
—
—
0
0
6
43
1.40
0.35
1.2
3.0
—
—
—
0
0
6
44
1.37
0.34
2.0
2.9
3.8
4.1
mmol/l
—
6
44
6
44
1.37
0.34
2.0
2.9
105.7
105.2
mmol/l
—
6
44
6
44
1.37
0.34
2.0
2.9
—
—
—
0
0
6
87
0.68
0.33
1.2
1.1
—
—
—
0
0
6
46
1.31
0.33
2.7
3.2
0.7
1.0
%
—
6
36
6
47
1.28
0.32
1.0
1.5
—
—
—
0
0
11
140
0.78
0.28
1.3
1.2
—
—
—
0
0
247
2527
0.92
0.25
4.3
4.4
6.1
6.0
mmol/l
0.30
226
2307
10
79
1.27
0.22
4.1
1.5
—
—
—
0
0
5
41
1.22
0.22
3.2
1.7
76.3
59.4
%
—
5
41
25
220
1.15
0.22
1.5
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
4.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
3.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
10
80
1.26
0.20
7.2
2.7
9.1
8.2
kpa
—
10
72
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
107
1022
1.07
0.20
2.5
2.0
—
—
—
0
0
12
101
1.19
0.17
1.7
2.6
—
—
—
0
0
60
567
1.07
0.15
1.4
1.3
1.1
2.0
u/ml
1.02
20
153
7
87
0.80
0.14
1.4
1.4
20.3
23.5
iu/l
—
7
70
62
652
0.94
0.14
3.8
2.6
312.9
7634.2
umol/l
3.22
52
560
10
84
1.20
0.14
4.2
1.5
—
—
—
0
0
10
85
1.18
0.12
4.0
1.5
—
—
—
0
0
10
85
1.18
0.12
4.1
1.5
—
—
—
0
0
44
418
1.06
0.10
1.2
1.3
23.4
34.6
iu/ml
0.58
14
138
32
301
1.07
0.09
1.7
2.3
129.3
120.7
ug/g
0.06
20
242
6
54
1.11
0.09
1.8
2.5
—
—
—
0
0
81
786
1.04
0.09
4.4
3.8
—
—
—
0
0
6
58
1.04
0.08
2.0
1.2
—
—
—
0
0
7
66
1.06
0.08
1.1
1.1
—
—
—
0
0
9
86
1.05
0.07
4.7
1.5
—
—
—
0
0
9
87
1.04
0.07
6.1
4.6
—
—
—
0
0
15
138
1.09
0.06
1.3
1.2
—
—
—
0
0
30
315
0.95
0.06
1.6
1.3
—
—
—
0
0
20
187
1.07
0.06
3.9
3.9
0.1
0.4
%
—
8
54
9
104
0.86
0.06
1.8
1.8
—
—
—
0
0
18
192
0.93
0.05
4.0
4.2
0.0
0.2
%
—
8
60
273
2715
1.02
0.04
25.7
16.0
3.9
4.0
mmol/l
2.06
266
2633
10
91
1.10
0.04
1.8
1.6
—
—
—
0
0
70
714
0.98
0.04
3.6
3.3
—
—
—
0
0
29
279
1.04
0.04
2.8
4.3
40.0
53.8
ug/l
0.11
22
233
236
2346
1.02
0.03
5.8
4.5
2.0
1.9
mu/l
0.72
215
2116
272
2708
1.02
0.03
26.8
15.9
139.5
139.7
mmol/l
0.46
265
2630
14
148
0.94
0.02
5.1
3.8
—
—
—
0
0
20
208
0.96
0.02
1.3
1.2
—
—
—
0
0
22
213
1.04
0.01
3.9
4.0
0.8
0.7
%
—
9
76
263
2637
0.99
0.01
23.2
13.9
30.0
23.4
mg/l
1.74
218
2085
191
1909
1.00
0.00
4.9
3.9
12.7
12.2
mm/h
0.13
177
1751
11
113
0.97
0.00
1.4
1.3
—
—
—
0
0
17
173
0.98
0.00
3.9
2.9
—
—
—
0
0
11
105
1.05
0.00
1.0
1.1
—
—
—
0
0
41
405
1.01
0.00
1.2
1.3
1.4
14.6
u/ml
—
9
153
36
356
1.01
0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
1.9
—
0
5
20
200
1.00
0.00
4.0
4.1
0.1
0.1
%
—
9
67
0
7
0.00
0.00
0.0
6.0
—
6.6
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
0.00
2.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
1.2
—
0
7
0
5
0.00
0.00
0.0
2.6
—
3706.6
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
18.1
—
0
6
0
6
0.00
0.00
0.0
7.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
0
7
0.00
0.00
0.0
5.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint G6_DISBROTHUNS and mortality.

Females

Parameter HR [95% CI] p-value
G6_DISBROTHUNS 3.99 [2.68, 5.94] < 0.001
Birth year 0.998 [0.99, 1.01] 0.697

During the follow-up period (1.1.1998 — 31.12.2019), 173 out of 487 females with G6_DISBROTHUNS died.

Males

Parameter HR [95% CI] p-value
G6_DISBROTHUNS 4.946 [3.66, 6.68] < 0.001
Birth year 0.99 [0.98, 1.0] 0.041

During the follow-up period (1.1.1998 — 31.12.2019), 227 out of 545 males with G6_DISBROTHUNS died.

Mortality risk

Mortality risk for people of age

years, who have G6_DISBROTHUNS.

N-year risk Females Males
1 0.44% 0.838%
5 2.171% 5.642%
10 6.164% 14.249%
15 11.626% 26.237%
20 20.3% 41.219%

Relationships between endpoints

↥

Index endpoint: G6_DISBROTHUNS – Disorders of brain, other and unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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