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Inflammation of lacrimal passages (chronic)

DOID EFO Endpoint Browser PheWeb

H7_LACRIMINFLAMCHRON

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H04.4
  • Hospital discharge: ICD-9 — 3754
  • Hospital discharge: ICD-8 — 36804
  • Cause of death: ICD-10 — H04.4
  • Cause of death: ICD-9 — 3754
  • Cause of death: ICD-8 — 36804

2 out of 7 registries used, show all original rules.

579

4. Check minimum number of events

None

579

5. Include endpoints

None

579

6. Filter based on genotype QC (FinnGen only)

579

Control definitions (FinnGen only)

Control exclude
H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H04
Name in latin
Inflammatio viarum lacrimalium chronica

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7052 5227 1789
Only index persons 5097 3749 1348
Unadjusted period prevalence (%)
Whole population 0.12 0.15 0.05
Only index persons 0.11 0.14 0.05
Median age at first event (years)
Whole population 63.41 65.52 57.34
Only index persons 59.43 62.29 51.49

-FinnGen-

Key figures

All Female Male
Number of individuals 579 400 179
Unadjusted period prevalence (%) 0.12 0.14 0.08
Median age at first event (years) 59.21 59.12 59.43

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
518
Matched controls
5179
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H04.4
ICD-10 Finland
Chronic inflammation of lacrimal passages
+∞
323.0
404
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
4642.9
305.7
264
*
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
2457.6
181.4
165
*
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
923.9
146.6
137
*
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
+∞
93.6
87
*
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
927.5
82.9
79
*
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
927.5
82.9
79
*
36804
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Dacryocystitis chronica
+∞
74.8
70
*
3754A
ICD-9 Finland
Disorders of lachrymal system, Chronic inflammation of lachrymal passages
+∞
60.6
57
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.5
56.7
330
1450
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
307.7
55.3
55
*
H04.0
ICD-10 Finland
Dacryoadenitis
+∞
55.2
52
*
3317
FHL
Transcutaneous dacryocystorinostomy (Toti)
+∞
44.4
42
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
8.5
41.5
96
135
H04.10
ICD-10 Finland
Dry eye syndrome
11.2
41.5
81
84
UDM02
NOMESCO Finland
Sinoscopy
23.1
38.8
56
27
CCD40
NOMESCO Finland
Percutaneous dacryocystorhinostomy
+∞
35.8
34
*
S01AX11
ATC
[U] ofloxacin; ophthalmic
7.7
29.4
71
105
3755A
ICD-9 Finland
Disorders of lachrymal system, Stenosis and insufficiency of lachrymal passages
+∞
28.4
27
*
H02.3
ICD-10 Finland
Blepharochalasis
52.9
25.5
30
6
CCD30
NOMESCO Finland
Reconstruction of lacrimal canaliculus
+∞
24.1
23
*
H04.2
ICD-10 Finland
Epiphora
131.1
23.8
25
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
20.5
270
1605
CCA20
NOMESCO Finland
Incision of lacrimal punctum or canaliculus
+∞
18.9
18
*
36802
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Obstructio, stenosis viarum lacrimalium
+∞
18.9
18
*
3329
FHL
Other measure in this category
+∞
16.8
16
*
H02.1
ICD-10 Finland
Ectropion of eyelid
+∞
15.7
15
*
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.9
14.5
48
106
ZXA05
NOMESCO Finland
Left side
2.2
13.8
175
970
CCC50
NOMESCO Finland
Dacryocystectomy
+∞
13.6
13
*
F03
ICPC
Eye discharge
4.4
13.0
47
114
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
133.1
12.5
13
*
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
4.7
12.4
42
95
J01DA01
ATC
[U] cefalexin; systemic
1.9
11.7
334
2500
H02.4
ICD-10 Finland
Ptosis of eyelid
35.9
11.3
14
*
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.3
11.0
40
98
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
3.6
10.7
48
142
J01DB01
ATC
cefalexin; oral
2.0
10.6
406
3325
3315
FHL
Tear bag removal
+∞
10.4
10
*
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
4.2
9.8
37
94
ZXA00
NOMESCO Finland
Right side
1.9
9.6
168
1035
H01.0
ICD-10 Finland
Blepharitis
5.2
9.4
28
56
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.9
8.9
55
204
S01GX01
ATC
cromoglicic acid; ophthalmic
2.2
8.7
94
474
ZXC10
NOMESCO Finland
Use of laser
6.7
8.3
20
31
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
3.1
8.2
44
151
R01AD09
ATC
mometasone; nasal
1.7
7.9
204
1408
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
7.6
92
485
R01AD08
ATC
fluticasone; nasal
1.9
7.5
133
812
J31.0
ICD-10 Finland
Chronic rhinitis
3.0
7.5
42
147
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
5.7
7.4
20
36
H00.1
ICD-10 Finland
Chalazion
8.5
7.4
15
18
M31.3
ICD-10 Finland
Wegener granulomatosis
20.3
7.2
10
5
J01AA02
ATC
doxycycline; systemic
1.7
7.1
389
3290
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
7.0
101
573
S01AA03
ATC
neomycin; ophthalmic (antibiotics)
14.0
6.9
11
8
S01AA12
ATC
tobramycin; ophthalmic
17.0
6.8
10
6
S01AA13
ATC
fusidic acid; ophthalmic
4.3
6.7
23
55
H10.4
ICD-10 Finland
Chronic conjunctivitis
10.2
6.6
12
12
F29
ICPC
Eye symptom/complaint other
2.6
6.5
46
189
J34.2
ICD-10 Finland
Deviated nasal septum
3.4
6.5
29
88
CCD99
NOMESCO Finland
Other reconstructive operation on lacrimal apparatus
+∞
6.3
6
*
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
6.3
6
*
3312
FHL
Probing under general anesthesia
+∞
6.3
6
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
27.0
6.2
8
*
H10
ICD-10 Finland
Conjunctivitis
3.1
6.2
32
108
H57.1
ICD-10 Finland
Ocular pain
5.5
6.2
17
32
J01FF01
ATC
clindamycin; systemic
1.7
6.2
135
877

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
120
502
2.75
19.62
2.3
1.6
—
—
—
0
0
159
1023
1.76
7.98
4.8
3.8
—
—
—
0
0
91
514
1.91
6.88
1.7
1.4
—
—
—
0
0
156
1097
1.58
5.29
2.0
2.2
—
—
—
0
0
308
2532
1.46
4.82
8.0
8.6
4.0
4.2
e9/l
1.23
260
2225
191
1434
1.50
4.72
2.1
2.4
—
—
—
0
0
492
4482
1.65
4.47
15.8
14.9
—
—
—
0
0
481
4359
1.61
4.45
17.5
15.2
24.4
24.9
mg/l
0.13
405
3458
236
1867
1.45
4.40
4.5
3.9
42.8
59.0
ng/l
0.36
179
1392
98
644
1.63
4.35
2.1
1.9
—
—
—
0
0
497
4547
1.66
4.34
20.9
18.4
139.5
139.6
mmol/l
0.15
485
4410
497
4556
1.64
4.19
21.0
18.5
4.0
4.0
mmol/l
0.10
482
4411
219
1731
1.43
4.01
2.3
2.2
—
—
—
0
0
498
4584
1.62
3.93
11.3
10.6
22.8
24.1
u/l
1.37
475
4383
514
4769
1.69
3.93
25.8
22.7
91.7
91.4
fl
0.66
508
4674
514
4770
1.69
3.91
25.8
22.6
30.4
30.3
pg
1.15
508
4674
514
4771
1.69
3.90
25.9
22.7
4.4
4.4
e12/l
0.14
506
4615
514
4772
1.69
3.88
25.9
22.7
6.6
6.8
e9/l
1.61
504
4614
514
4773
1.68
3.86
25.9
22.8
132.3
132.2
g/l
0.07
509
4675
252
2054
1.40
3.83
4.2
4.5
34.9
34.9
g/l
0.03
230
1900
134
973
1.49
3.80
5.5
4.6
1.0
1.0
kg/l
1.16
17
143
513
4769
1.66
3.74
26.0
22.7
241.9
248.7
e9/l
1.64
505
4625
372
3267
1.39
3.47
4.6
4.1
12.4
14.0
mm/h
1.86
346
2970
250
2077
1.36
3.23
3.8
4.1
—
—
—
0
0
352
3086
1.36
3.18
6.0
5.0
12.6
2753.2
e6/l
—
7
54
128
952
1.44
3.18
2.5
2.9
2.4
2.5
mmol/l
1.25
111
843
389
3466
1.37
3.16
7.5
7.3
76.4
79.6
u/l
0.35
366
3208
312
2694
1.34
3.07
4.6
4.7
6.6
6.8
mmol/l
0.70
296
2517
179
1428
1.37
2.94
2.1
2.0
138.9
249.6
u/l
1.26
164
1346
180
1438
1.37
2.93
5.7
5.0
—
—
—
0
0
263
2226
1.33
2.92
4.8
4.0
0.0
0.0
estimate
0.50
38
401
258
2185
1.33
2.82
4.6
4.0
0.0
0.0
estimate
0.00
39
416
260
2210
1.32
2.75
5.9
5.4
0.0
0.0
estimate
0.50
39
409
438
4014
1.37
2.73
5.9
4.9
2.0
2.0
mu/l
0.31
397
3597
352
3130
1.32
2.66
4.7
4.1
—
—
—
0
0
256
2180
1.31
2.65
5.6
5.8
1.2
1.2
mmol/l
0.25
228
1946
60
396
1.57
2.64
4.6
3.6
—
—
—
0
0
454
4200
1.37
2.55
4.8
4.5
4.6
4.6
mmol/l
0.28
416
3795
232
1959
1.31
2.52
13.1
10.0
1.4
1.3
inr
0.60
54
547
374
3369
1.31
2.49
4.8
4.0
15.0
15.0
pmol/l
0.08
339
3002
65
444
1.52
2.47
2.8
2.5
3.2
7.1
ug/l
3.64
54
383
201
1673
1.31
2.40
2.6
3.4
2.3
2.4
mmol/l
0.55
170
1428
463
4311
1.37
2.38
5.4
5.1
2.6
2.7
mmol/l
0.50
422
3878
258
2226
1.29
2.33
6.4
5.3
0.2
0.2
e9/l
0.25
217
1947
49
323
1.56
2.20
1.2
1.2
—
—
—
0
0
33
531
0.60
2.19
2.3
4.0
8.4
30.6
ug/l
0.83
24
444
437
4052
1.32
2.18
6.1
6.2
40.0
40.4
mmol/mol
0.48
398
3711
254
2202
1.27
2.17
6.5
5.1
1.8
1.9
e9/l
0.87
216
1934
25
137
1.86
2.17
19.2
9.4
—
—
—
0
0
273
2388
1.27
2.16
5.8
6.6
1.2
1.2
mmol/l
0.16
229
2001
455
4246
1.33
2.15
5.0
4.8
5.9
6.0
mmol/l
0.70
412
3785
174
1440
1.30
2.14
3.0
3.9
7.4
7.4
ph
0.00
24
268
125
992
1.33
2.07
5.3
5.1
3.1
2.9
ug/l
0.10
114
864
345
3116
1.27
2.05
5.2
4.6
—
—
—
0
0
185
1551
1.28
2.05
3.2
3.2
1477.5
1603.5
ng/l
0.17
168
1321
113
888
1.34
2.00
1.2
1.2
2.7
1.6
u/ml
0.36
28
228
135
1096
1.30
1.90
2.7
2.6
4833.1
8005.7
umol/l
0.42
113
922
79
592
1.39
1.89
5.3
6.0
104.4
104.0
mmol/l
0.42
79
571
193
1648
1.26
1.81
3.7
3.5
—
—
—
0
0
235
2053
1.24
1.79
6.7
5.1
57.5
58.3
%
0.44
213
1908
147
1216
1.28
1.79
5.4
4.4
0.0
0.0
estimate
0.50
36
405
236
2073
1.23
1.69
6.9
5.4
27.2
26.8
%
0.20
209
1914
223
1950
1.23
1.66
2.1
2.1
95.2
94.4
pmol/l
0.08
105
970
131
1079
1.28
1.64
6.0
6.6
—
—
—
0
0
243
2148
1.23
1.63
6.6
5.0
0.0
0.0
e9/l
0.45
206
1857
242
2140
1.22
1.61
6.6
5.0
0.6
0.6
e9/l
0.26
205
1848
28
175
1.63
1.61
3.0
2.8
—
—
—
0
0
429
4026
1.25
1.59
4.2
4.1
1.3
1.3
mmol/l
0.55
385
3587
230
2033
1.22
1.52
7.1
5.5
8.7
8.6
%
0.22
211
1889
39
268
1.49
1.51
1.2
1.3
—
—
—
0
0
442
4172
1.25
1.50
4.8
4.5
1.5
1.5
mmol/l
0.16
399
3751
270
2428
1.21
1.49
5.8
5.9
11.7
11.7
umol/l
0.01
252
2290
22
132
1.69
1.48
1.2
1.2
—
—
—
0
0
165
1415
1.23
1.45
4.7
4.2
—
—
—
0
0
153
1304
1.24
1.43
4.5
4.0
—
—
—
0
0
67
514
1.34
1.42
1.3
1.3
818.5
453.2
titre
0.41
13
121
88
705
1.29
1.38
1.4
1.3
15.1
36.8
iu/ml
3.77
26
225
72
561
1.32
1.38
2.9
3.0
0.8
0.8
ug/l
0.13
51
363
227
2021
1.20
1.36
6.8
5.2
3.0
2.7
%
1.05
209
1862
21
128
1.66
1.35
3.5
3.4
—
—
—
0
0
19
113
1.70
1.33
1.3
1.1
—
—
—
0
0
5
18
2.79
1.28
4.4
2.4
33.4
22.7
mu/l
—
5
18
95
776
1.27
1.28
1.3
1.4
2.3
2.5
g/l
0.65
54
440
8
35
2.30
1.27
1.3
1.1
—
—
—
0
0
44
323
1.39
1.24
4.1
5.8
—
—
—
0
0
35
247
1.44
1.22
2.8
2.5
—
—
—
0
0
187
1653
1.19
1.19
3.7
3.8
97.8
99.7
e6/l
0.02
126
1204
6
26
2.32
1.19
1.0
1.2
—
—
—
0
0
21
133
1.60
1.19
1.4
1.4
297.0
291.9
ug/g
0.04
14
78
21
135
1.58
1.13
1.4
1.6
—
—
—
0
0
68
548
1.27
1.05
5.6
7.5
1.2
1.4
mmol/l
0.09
58
425
32
230
1.41
1.04
7.1
11.0
—
—
—
0
0
118
1012
1.21
1.04
2.2
2.7
6.3
6.6
e6/l
0.09
101
902
217
1963
1.17
1.03
7.0
5.2
0.7
0.7
%
0.16
197
1811
5
22
2.28
1.03
2.6
1.1
6.4
5.6
ug/l
—
5
17
5
22
2.28
1.03
3.0
3.2
—
—
—
0
0
66
531
1.27
1.03
1.3
1.3
—
—
—
0
0
114
1322
0.83
1.03
3.1
3.2
—
—
—
0
0
151
1328
1.19
1.01
2.8
3.2
0.4
0.5
e6/l
0.11
113
1016
81
673
1.24
0.97
40.4
25.3
1.4
1.3
inr
—
8
83
145
1278
1.18
0.95
2.7
3.1
—
—
—
0
0
6
119
0.50
0.94
2.7
2.9
7.2
8.1
kpa
—
6
110
17
109
1.58
0.94
3.9
3.6
23.0
28.9
mg/l
—
9
68
20
286
0.69
0.87
2.5
3.9
—
—
—
0
0
8
45
1.79
0.84
1.1
1.4
—
—
—
0
0
8
45
1.79
0.84
1.1
1.4
—
—
—
0
0
8
45
1.79
0.84
1.1
1.4
—
—
—
0
0
8
45
1.79
0.84
1.1
1.4
—
—
—
0
0
80
677
1.21
0.82
1.4
1.3
2.0
14.4
u/ml
3.76
31
246
10
162
0.61
0.78
3.0
4.6
—
—
—
0
0
0
27
0.00
0.77
0.0
2.3
—
41.5
—
0
8
18
254
0.70
0.75
3.3
3.1
0.0
0.3
e6/l
2.88
18
248
5
24
2.09
0.74
1.2
1.2
—
—
—
0
0
8
134
0.59
0.74
1.5
1.3
—
—
—
0
0
116
1027
1.16
0.73
1.7
1.8
1330.1
1209.2
nmol/l
0.71
89
751
10
60
1.68
0.72
1.3
1.5
—
—
—
0
0
9
57
1.59
0.71
1.1
1.1
—
—
—
0
0
22
160
1.39
0.71
4.4
3.6
3.8
3.9
mmol/l
0.17
22
144
56
465
1.23
0.71
3.2
3.3
5.7
5.8
kpa
0.16
56
448
107
1205
0.86
0.69
3.8
3.8
—
—
—
0
0
5
27
1.86
0.68
1.0
1.2
—
—
—
0
0
48
580
0.81
0.68
2.6
2.4
1.7
1.8
%
0.21
37
507
33
259
1.29
0.67
1.1
1.2
90.2
152.7
iu/ml
—
9
95
369
3532
1.12
0.67
20.9
19.1
13.8
13.8
%
0.44
362
3450
56
469
1.21
0.66
1.9
2.0
96.3
134.5
ug/g
0.91
43
367
5
28
1.79
0.66
2.0
2.4
—
—
—
0
0
5
28
1.79
0.66
1.4
1.8
—
—
—
0
0
155
1411
1.13
0.66
2.6
2.5
62.4
56.2
u/l
0.30
141
1288
7
44
1.60
0.65
3.3
3.0
—
—
—
0
0
135
1220
1.14
0.64
2.2
2.2
3.0
3.2
mg/l
0.54
113
1027
55
463
1.21
0.62
3.2
3.4
1.7
2.0
mmol/l
0.20
49
362
12
80
1.51
0.60
1.2
1.3
—
—
—
0
0
11
72
1.54
0.59
1.3
1.4
—
—
—
0
0
57
486
1.19
0.58
5.1
4.2
—
—
—
0
0
50
421
1.21
0.58
5.0
6.1
1.6
1.5
mmol/l
0.12
50
397
396
3823
1.11
0.57
19.5
16.9
39.0
38.8
%
0.18
264
2484
11
73
1.52
0.56
1.7
1.4
33.3
32.9
g/l
0.03
11
65
8
55
1.46
0.56
15.9
6.5
7.2
7.1
mmol/l
—
8
41
32
394
0.80
0.56
4.3
4.0
—
—
—
0
0
9
132
0.68
0.52
2.7
3.0
23.5
25.3
mmol/l
—
9
114
101
910
1.13
0.51
5.5
4.1
320.9
266.2
ng/l
0.09
86
758
11
75
1.48
0.51
1.3
1.4
—
—
—
0
0
45
381
1.20
0.50
6.4
7.4
—
—
—
0
0
7
45
1.56
0.49
1.0
1.2
—
—
—
0
0
11
76
1.46
0.48
1.3
1.4
—
—
—
0
0
11
76
1.46
0.48
1.3
1.4
—
—
—
0
0
11
76
1.46
0.48
1.3
1.4
—
—
—
0
0
31
254
1.23
0.48
1.3
1.3
—
—
—
0
0
8
117
0.68
0.46
1.6
2.4
—
—
—
0
0
19
147
1.30
0.45
1.2
1.2
3.2
2.3
u/ml
—
5
12
24
192
1.26
0.45
4.9
4.2
—
—
—
0
0
14
103
1.37
0.45
1.7
2.8
—
—
—
0
0
7
50
1.40
0.45
1.7
1.2
—
—
—
0
0
155
1444
1.10
0.45
3.0
3.3
19.6
56.0
e6/l
2.11
117
1125
37
312
1.20
0.44
1.6
1.4
—
—
—
0
0
7
51
1.38
0.44
1.0
1.3
—
—
—
0
0
6
94
0.63
0.42
2.7
2.9
—
—
—
0
0
5
32
1.57
0.42
1.0
1.0
—
—
—
0
0
5
32
1.57
0.42
1.2
1.0
1.4
1.5
nmol/l
—
5
26
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
198
1873
1.09
0.41
2.5
2.7
120.7
129.7
ug/l
0.29
180
1682
37
432
0.85
0.41
2.6
2.5
70.4
69.5
e9/l
0.07
31
346
0
17
0.00
0.40
0.0
1.3
—
40.1
—
0
8
5
34
1.47
0.40
1.2
1.0
—
—
—
0
0
5
34
1.47
0.40
1.0
1.4
12.2
9.2
%
—
5
34
8
60
1.34
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
49.9
—
0
7
0
18
0.00
0.40
0.0
2.8
—
29.9
—
0
10
20
248
0.80
0.40
1.4
1.3
—
—
—
0
0
7
103
0.68
0.40
2.0
3.5
—
—
—
0
0
8
61
1.32
0.39
1.0
1.0
—
—
—
0
0
5
36
1.39
0.38
2.4
1.9
—
—
—
0
0
13
98
1.33
0.37
2.2
1.5
4.7
4.8
iu/l
—
7
23
5
37
1.35
0.37
1.0
1.2
—
—
—
0
0
31
363
0.85
0.36
1.4
1.4
—
—
—
0
0
6
43
1.40
0.35
1.5
1.3
—
—
—
0
0
10
73
1.38
0.34
1.2
3.1
—
—
—
0
0
6
44
1.37
0.34
2.0
2.4
—
—
—
0
0
6
44
1.37
0.34
1.5
1.4
—
—
—
0
0
86
933
0.91
0.33
5.0
4.5
—
—
—
0
0
6
87
0.69
0.33
1.5
1.3
68473.3
225.3
e6/l
—
6
71
6
87
0.69
0.33
1.5
1.2
33.2
17.2
e6/l
—
6
69
6
47
1.28
0.32
2.2
1.3
—
—
—
0
0
17
207
0.82
0.30
1.2
1.8
1.5
1.6
g/l
0.21
12
182
37
419
0.88
0.30
1.4
1.5
—
—
—
0
0
7
55
1.28
0.30
1.0
3.7
—
—
—
0
0
7
57
1.23
0.29
2.4
2.9
—
—
—
0
0
103
965
1.08
0.28
1.8
1.6
1.7
1.3
mg/l
0.41
79
761
8
63
1.27
0.28
2.0
1.6
—
—
—
0
0
199
1910
1.06
0.28
10.2
9.4
0.0
0.0
e9/l
0.75
164
1568
9
116
0.77
0.27
1.1
1.7
—
—
—
0
0
104
978
1.08
0.26
2.1
2.9
535.5
531.6
mosm/kgh2o
0.07
85
835
22
189
1.17
0.24
1.1
1.2
—
—
—
0
0
9
77
1.17
0.24
4.1
2.6
4.2
4.4
e9/l
—
9
77
20
233
0.85
0.24
1.2
1.3
—
—
—
0
0
114
1080
1.07
0.24
1.7
1.8
420.2
13371874.6
pmol/l
0.80
90
875
44
399
1.11
0.24
1.3
1.4
—
—
—
0
0
30
266
1.13
0.23
3.6
3.2
25.0
24.9
mmol/l
0.05
30
259
17
200
0.85
0.23
1.6
2.0
—
—
—
0
0
5
39
1.28
0.23
1.0
1.6
—
—
—
0
0
7
93
0.75
0.22
2.4
1.5
—
—
—
0
0
5
41
1.22
0.22
3.2
2.7
—
—
—
0
0
13
107
1.22
0.21
1.2
1.5
34.1
24.2
iu/l
0.41
13
95
5
42
1.19
0.21
1.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
142
1362
1.06
0.20
2.8
3.2
581.4
281.8
mg/l
0.23
77
845
6
48
1.25
0.20
1.0
1.1
—
—
—
0
0
13
108
1.21
0.20
1.3
1.1
—
—
—
0
0
9
114
0.79
0.20
1.1
4.1
—
—
—
0
0
6
51
1.18
0.19
1.2
1.2
—
—
—
0
0
10
81
1.24
0.19
1.2
1.3
—
—
—
0
0
15
128
1.18
0.18
1.7
3.4
7.4
7.4
ph
—
8
100
115
1200
0.95
0.18
1.5
1.6
22.8
20.6
nmol/l
0.75
99
994
13
153
0.85
0.18
2.5
1.7
—
—
—
0
0
7
62
1.13
0.17
1.6
1.3
—
—
—
0
0
13
110
1.19
0.17
1.0
1.1
—
—
—
0
0
8
68
1.18
0.16
1.6
1.3
10.3
11.6
u/l
—
8
58
71
749
0.94
0.16
1.7
2.4
12.8
12.2
umol/l
0.28
64
671
32
349
0.91
0.16
3.7
4.1
0.0
0.1
%
—
7
95
9
81
1.11
0.15
6.2
2.9
56.9
60.1
%
—
9
81
7
87
0.80
0.14
2.3
2.4
—
—
—
0
0
34
367
0.92
0.14
3.5
4.1
0.0
0.1
%
—
8
110
37
396
0.93
0.13
3.5
3.9
0.6
1.0
%
—
10
124
23
252
0.91
0.13
1.7
1.5
1.0
1.6
g/l
1.03
18
231
66
691
0.95
0.12
1.7
2.4
2.3
2.3
g/l
0.13
61
621
62
649
0.95
0.11
1.7
2.4
23.0
21.2
%
0.35
49
541
21
192
1.10
0.11
1.2
1.5
—
—
—
0
0
34
361
0.94
0.10
1.3
2.5
—
—
—
0
0
31
330
0.94
0.09
1.6
1.5
—
—
—
0
0
108
1051
1.03
0.09
1.3
1.3
—
—
—
0
0
44
419
1.05
0.09
1.7
2.7
67.5
66.6
g/l
0.35
38
372
51
489
1.05
0.08
1.3
1.6
—
—
—
0
0
6
58
1.03
0.08
1.0
1.3
—
—
—
0
0
5
65
0.77
0.08
1.0
1.2
—
—
—
0
0
63
609
1.04
0.07
1.1
1.2
—
—
—
0
0
24
225
1.07
0.07
4.0
3.8
—
—
—
0
0
39
408
0.95
0.07
2.7
3.8
1.2
1.2
mmol/l
1.15
33
355
8
75
1.07
0.07
1.3
1.7
234.6
315.2
mu/l
—
8
70
33
346
0.95
0.07
3.4
4.0
0.2
0.4
%
—
6
87
21
224
0.94
0.07
1.3
1.3
—
—
—
0
0
114
1118
1.02
0.06
1.6
1.6
1.4
1.3
mmol/l
0.43
99
923
19
179
1.06
0.05
2.0
1.5
—
—
—
0
0
10
91
1.10
0.04
2.6
1.7
—
—
—
0
0
48
493
0.97
0.04
3.1
2.6
8.6
9.6
umol/l
0.09
36
422
74
726
1.02
0.04
2.7
3.1
0.9
0.8
mmol/l
3.43
69
672
42
431
0.97
0.03
2.3
2.0
0.2
0.2
g/l
1.12
36
400
40
410
0.97
0.02
1.4
1.6
—
—
—
0
0
48
490
0.98
0.02
1.1
1.3
—
—
—
0
0
34
332
1.03
0.02
4.5
3.0
—
—
—
0
0
141
1403
1.01
0.00
2.8
3.1
6.2
6.9
mmol/l
1.34
119
1165
13
129
1.01
0.00
1.3
1.1
—
—
—
0
0
5
56
0.89
0.00
2.2
1.4
—
—
—
0
0
9
99
0.91
0.00
1.7
1.3
564.9
501.4
mg/l
—
9
94
0
8
0.00
0.00
0.0
1.1
—
7.6
—
0
8
5
53
0.94
0.00
3.0
3.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
5
55
0.91
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
3.8
—
—
—
0
0
5
59
0.85
0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
145
1450
1.00
0.00
3.5
4.0
7.3
7.9
mg/mmol
0.05
83
902
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
8
80
1.00
0.00
2.6
1.4
—
—
—
0
0
5
50
1.00
0.00
2.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
18.7
—
0
7
6
60
1.00
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
9.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
18.3
—
0
8
6
68
0.88
0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
1.3
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_LACRIMINFLAMCHRON and mortality.

Females

Parameter HR [95% CI] p-value
H7_LACRIMINFLAMCHRON 0.99 [0.89, 1.11] 0.858
Birth year 0.995 [0.99, 1.0] 0.231

During the follow-up period (1.1.1998 — 31.12.2019), 939 out of 2779 females with H7_LACRIMINFLAMCHRON died.

Males

Parameter HR [95% CI] p-value
H7_LACRIMINFLAMCHRON 0.993 [0.84, 1.18] 0.931
Birth year 0.991 [0.98, 1.0] 0.127

During the follow-up period (1.1.1998 — 31.12.2019), 290 out of 989 males with H7_LACRIMINFLAMCHRON died.

Mortality risk

Mortality risk for people of age

years, who have H7_LACRIMINFLAMCHRON.

N-year risk Females Males
1 0.102% 0.225%
5 0.573% 1.344%
10 1.423% 3.252%
15 2.833% 6.231%
20 5.208% 10.524%

Relationships between endpoints

↥

Index endpoint: H7_LACRIMINFLAMCHRON – Inflammation of lacrimal passages (chronic)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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