No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
579 |
4. Check minimum number of eventsNone |
579 |
5. Include endpointsNone |
579 |
6. Filter based on genotype QC (FinnGen only) |
579 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H04
- Name in latin
- Inflammatio viarum lacrimalium chronica
Similar endpoints
↥List of similar endpoints to
Inflammation of lacrimal passages (chronic)
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7052 | 5227 | 1789 |
| Only index persons | 5097 | 3749 | 1348 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.15 | 0.05 |
| Only index persons | 0.11 | 0.14 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 63.41 | 65.52 | 57.34 |
| Only index persons | 59.43 | 62.29 | 51.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 579 | 400 | 179 |
| Unadjusted period prevalence (%) | 0.12 | 0.14 | 0.08 |
| Median age at first event (years) | 59.21 | 59.12 | 59.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 518
- Matched controls
- 5179
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H04.4
ICD-10 Finland
Chronic inflammation of lacrimal passages
+∞
323.0
404
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
4642.9
305.7
264
*
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
2457.6
181.4
165
*
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
923.9
146.6
137
*
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
+∞
93.6
87
*
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
927.5
82.9
79
*
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
927.5
82.9
79
*
36804
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Dacryocystitis chronica
+∞
74.8
70
*
3754A
ICD-9 Finland
Disorders of lachrymal system, Chronic inflammation of lachrymal passages
+∞
60.6
57
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.5
56.7
330
1450
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
307.7
55.3
55
*
H04.0
ICD-10 Finland
Dacryoadenitis
+∞
55.2
52
*
3317
FHL
Transcutaneous dacryocystorinostomy (Toti)
+∞
44.4
42
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
8.5
41.5
96
135
H04.10
ICD-10 Finland
Dry eye syndrome
11.2
41.5
81
84
UDM02
NOMESCO Finland
Sinoscopy
23.1
38.8
56
27
CCD40
NOMESCO Finland
Percutaneous dacryocystorhinostomy
+∞
35.8
34
*
S01AX11
ATC
[U] ofloxacin; ophthalmic
7.7
29.4
71
105
3755A
ICD-9 Finland
Disorders of lachrymal system, Stenosis and insufficiency of lachrymal passages
+∞
28.4
27
*
H02.3
ICD-10 Finland
Blepharochalasis
52.9
25.5
30
6
CCD30
NOMESCO Finland
Reconstruction of lacrimal canaliculus
+∞
24.1
23
*
H04.2
ICD-10 Finland
Epiphora
131.1
23.8
25
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
20.5
270
1605
CCA20
NOMESCO Finland
Incision of lacrimal punctum or canaliculus
+∞
18.9
18
*
36802
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Obstructio, stenosis viarum lacrimalium
+∞
18.9
18
*
3329
FHL
Other measure in this category
+∞
16.8
16
*
H02.1
ICD-10 Finland
Ectropion of eyelid
+∞
15.7
15
*
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.9
14.5
48
106
ZXA05
NOMESCO Finland
Left side
2.2
13.8
175
970
CCC50
NOMESCO Finland
Dacryocystectomy
+∞
13.6
13
*
F03
ICPC
Eye discharge
4.4
13.0
47
114
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
133.1
12.5
13
*
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
4.7
12.4
42
95
J01DA01
ATC
[U] cefalexin; systemic
1.9
11.7
334
2500
H02.4
ICD-10 Finland
Ptosis of eyelid
35.9
11.3
14
*
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.3
11.0
40
98
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
3.6
10.7
48
142
J01DB01
ATC
cefalexin; oral
2.0
10.6
406
3325
3315
FHL
Tear bag removal
+∞
10.4
10
*
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
4.2
9.8
37
94
ZXA00
NOMESCO Finland
Right side
1.9
9.6
168
1035
H01.0
ICD-10 Finland
Blepharitis
5.2
9.4
28
56
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.9
8.9
55
204
S01GX01
ATC
cromoglicic acid; ophthalmic
2.2
8.7
94
474
ZXC10
NOMESCO Finland
Use of laser
6.7
8.3
20
31
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
3.1
8.2
44
151
R01AD09
ATC
mometasone; nasal
1.7
7.9
204
1408
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
7.6
92
485
R01AD08
ATC
fluticasone; nasal
1.9
7.5
133
812
J31.0
ICD-10 Finland
Chronic rhinitis
3.0
7.5
42
147
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
5.7
7.4
20
36
H00.1
ICD-10 Finland
Chalazion
8.5
7.4
15
18
M31.3
ICD-10 Finland
Wegener granulomatosis
20.3
7.2
10
5
J01AA02
ATC
doxycycline; systemic
1.7
7.1
389
3290
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
7.0
101
573
S01AA03
ATC
neomycin; ophthalmic (antibiotics)
14.0
6.9
11
8
S01AA12
ATC
tobramycin; ophthalmic
17.0
6.8
10
6
S01AA13
ATC
fusidic acid; ophthalmic
4.3
6.7
23
55
H10.4
ICD-10 Finland
Chronic conjunctivitis
10.2
6.6
12
12
F29
ICPC
Eye symptom/complaint other
2.6
6.5
46
189
J34.2
ICD-10 Finland
Deviated nasal septum
3.4
6.5
29
88
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
6.3
6
*
CCD99
NOMESCO Finland
Other reconstructive operation on lacrimal apparatus
+∞
6.3
6
*
3312
FHL
Probing under general anesthesia
+∞
6.3
6
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
27.0
6.2
8
*
H10
ICD-10 Finland
Conjunctivitis
3.1
6.2
32
108
H57.1
ICD-10 Finland
Ocular pain
5.5
6.2
17
32
J01FF01
ATC
clindamycin; systemic
1.7
6.2
135
877
Mortality – FinRegistry
↥Association
Association between endpoint H7_LACRIMINFLAMCHRON and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LACRIMINFLAMCHRON | 0.99 [0.89, 1.11] | 0.858 |
| Birth year | 0.995 [0.99, 1.0] | 0.231 |
During the follow-up period (1.1.1998 — 31.12.2019), 939 out of 2779 females with H7_LACRIMINFLAMCHRON died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LACRIMINFLAMCHRON | 0.993 [0.84, 1.18] | 0.931 |
| Birth year | 0.991 [0.98, 1.0] | 0.127 |
During the follow-up period (1.1.1998 — 31.12.2019), 290 out of 989 males with H7_LACRIMINFLAMCHRON died.
Mortality risk
Mortality risk for people of age
years, who have H7_LACRIMINFLAMCHRON.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.102% | 0.225% |
| 5 | 0.573% | 1.344% |
| 10 | 1.423% | 3.252% |
| 15 | 2.833% | 6.231% |
| 20 | 5.208% | 10.524% |
Relationships between endpoints
↥Index endpoint: H7_LACRIMINFLAMCHRON – Inflammation of lacrimal passages (chronic)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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