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Inflammation of lacrimal passages (chronic)

DOID EFO Endpoint Browser PheWeb

H7_LACRIMINFLAMCHRON

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H04.4
  • Hospital discharge: ICD-9 — 3754
  • Hospital discharge: ICD-8 — 36804
  • Cause of death: ICD-10 — H04.4
  • Cause of death: ICD-9 — 3754
  • Cause of death: ICD-8 — 36804

2 out of 7 registries used, show all original rules.

598

4. Check minimum number of events

None

598

5. Include endpoints

None

598

6. Filter based on genotype QC (FinnGen only)

581

Control definitions (FinnGen only)

Control exclude
H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H04
Name in latin
Inflammatio viarum lacrimalium chronica

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7052 5227 1789
Only index persons 5097 3749 1348
Unadjusted period prevalence (%)
Whole population 0.12 0.15 0.05
Only index persons 0.11 0.14 0.05
Median age at first event (years)
Whole population 63.41 65.52 57.34
Only index persons 59.43 62.29 51.49

-FinnGen-

Key figures

All Female Male
Number of individuals 581 405 176
Unadjusted period prevalence (%) 0.12 0.14 0.08
Median age at first event (years) 60.35 59.94 61.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
598
Matched controls
5980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
816.8
307.7
312
8
H04.4
ICD-10 Finland
Chronic inflammation of lacrimal passages
+∞
307.7
474
*
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
+∞
213.7
192
*
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
2396.3
183.1
168
*
CCD50
NOMESCO Finland
Dacryocystorhinostomy with insertion of tube
+∞
114.3
106
*
H04.3
ICD-10 Finland
Acute and unspecified inflammation of lacrimal passages
245.3
102.0
102
5
TCC30
NOMESCO Finland
Intubation of lacrimal canaliculus/duct
1041.3
93.5
89
*
36804
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Dacryocystitis chronica
+∞
83.3
78
*
UDM02
NOMESCO Finland
Sinoscopy
19.3
79.3
64
37
UDH02
NOMESCO Finland
Rhinopharyngoscopy
7.9
74.1
114
174
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.7
73.3
391
1724
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
763.4
70.6
68
*
H04.0
ICD-10 Finland
Dacryoadenitis
700.4
65.2
63
*
3754A
ICD-9 Finland
Disorders of lachrymal system, Chronic inflammation of lachrymal passages
+∞
64.8
61
*
H04.10
ICD-10 Finland
Dry eye syndrome
7.2
62.6
103
168
S01AX11
ATC
[U] ofloxacin
7.8
54.3
81
118
3317
FHL
Transcutaneous dacryocystorinostomy (Toti)
+∞
49.7
47
*
CCD40
NOMESCO Finland
Percutaneous dacryocystorhinostomy
+∞
44.3
42
*
3755A
ICD-9 Finland
Disorders of lachrymal system, Stenosis and insufficiency of lachrymal passages
+∞
32.6
31
*
H02.3
ICD-10 Finland
Blepharochalasis
63.7
31.4
36
6
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
5.0
29.7
68
149
H04.2
ICD-10 Finland
Epiphora
81.7
28.0
31
*
CCD30
NOMESCO Finland
Reconstruction of lacrimal canaliculus
294.6
28.0
28
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.6
27.9
339
2020
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
5.1
24.6
54
114
F03
ICPC
Eye discharge
4.5
23.0
60
146
S01AA01
ATC
chloramphenicol; ophthalmic
4.4
22.5
59
144
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
5.0
22.4
50
107
CCA20
NOMESCO Finland
Incision of lacrimal punctum or canaliculus
+∞
22.0
21
*
36802
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Obstructio, stenosis viarum lacrimalium
+∞
21.0
20
*
ZXA05
NOMESCO Finland
Left side
2.3
18.8
202
1093
H01.0
ICD-10 Finland
Blepharitis
5.1
18.5
40
83
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
8.0
17.5
24
31
3329
FHL
Other measure in this category
+∞
16.7
16
*
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
+∞
16.7
16
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
174.7
16.6
17
*
H02.1
ICD-10 Finland
Ectropion of eyelid
61.7
15.8
18
*
CCC50
NOMESCO Finland
Dacryocystectomy
+∞
15.7
15
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
3.4
15.6
58
181
ZXA00
NOMESCO Finland
Right side
2.1
14.7
197
1145
F29
ICPC
Eye symptom/complaint other
3.0
14.0
68
249
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.5
13.7
48
144
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.8
13.1
68
258
H02.4
ICD-10 Finland
Ptosis of eyelid
20.6
12.5
18
9
S01AA13
ATC
fusidic acid; ophthalmic
4.8
12.5
28
60
J01DB01
ATC
cefalexin; oral
2.1
12.5
479
3905
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
12.4
120
610
S01GX01
ATC
cromoglicic acid; ophthalmic
2.2
11.6
117
604
S01ED51
ATC
timolol, combinations; ophthalmic
2.4
10.5
75
334
3315
FHL
Tear bag removal
+∞
10.4
10
*
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
+∞
10.4
10
*
H57.1
ICD-10 Finland
Ocular pain
4.5
10.4
25
57
S01GX08
ATC
ketotifen; ophthalmic
3.8
10.3
31
84
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.0
10.2
131
738
J01FF01
ATC
clindamycin; systemic
1.9
9.9
163
997
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
5.0
9.9
21
43
R01AD08
ATC
fluticasone; nasal
1.9
9.7
156
945
S01ED01
ATC
timolol; ophthalmic
3.1
9.5
41
140
J31.0
ICD-10 Finland
Chronic rhinitis
2.7
9.2
51
200
J01DA01
ATC
[U] cefalexin
1.7
8.8
371
2929
S01EA05
ATC
brimonidine; ophthalmic
3.4
8.7
31
94
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.3
8.7
72
341
ZXA10
NOMESCO Finland
Bilateral
1.9
8.5
129
763
S01GX02
ATC
levocabastine; ophthalmic
2.9
8.5
41
150
H10
ICD-10 Finland
Conjunctivitis
2.9
8.5
41
150
J34.2
ICD-10 Finland
Deviated nasal septum
3.2
8.4
34
112
114
Kela drug reimbursment
Glaucoma
2.1
8.4
83
423
CCA30
NOMESCO Finland
Incision of lacrimal sac
+∞
8.3
8
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
8.2
217
1509
S18
ICPC
Laceration/cut
1.7
8.2
261
1905
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.5
8.2
28
83
S01AA12
ATC
tobramycin; ophthalmic
17.5
8.1
12
7
H00.03
ICD-10 Finland
Preseptal cellulite in the eyelid
33.8
8.1
10
*
R01AD09
ATC
mometasone; nasal
1.7
7.9
235
1681
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.5
7.9
27
80
ZXC10
NOMESCO Finland
Use of laser
4.0
7.8
22
57
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.5
7.8
26
76
J01AA02
ATC
doxycycline; systemic
1.7
7.6
449
3799
Z97.4
ICD-10 Finland
Presence of external hearing-aid
2.6
7.6
44
177
R01AD58
ATC
fluticasone, combinations; nasal
1.9
7.4
107
621
CBB20
NOMESCO Finland
Correction of lax skin of eyelid and resection of herniated fat
81.1
7.4
8
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
7.3
224
1606
S01AA03
ATC
neomycin; ophthalmic
11.0
7.3
13
12
CCC99
NOMESCO Finland
Other operation on lacrimal passages
+∞
7.3
7
*
F73
ICPC
Eye infection/inflammation other
5.7
7.1
19
34
S01EE04
ATC
travoprost; ophthalmic
3.8
7.0
21
57
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
14.0
6.9
11
8
WX002
NOMESCO Finland
Sedation and analgesia
1.8
6.8
119
732
S01GA55
ATC
phenylephrine, combinations; ophthalmic
40.5
6.8
8
*
J33.0
ICD-10 Finland
Polyp of nasal cavity
3.8
6.7
20
54
N05BA04
ATC
oxazepam; oral
1.7
6.7
162
1092
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
6.7
144
941
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
12.4
6.6
11
9
H10.4
ICD-10 Finland
Chronic conjunctivitis
8.8
6.6
13
15
R42
ICD-10 Finland
Dizziness and giddiness
1.7
6.6
155
1037
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.9
6.5
88
500
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.4
6.5
44
191
3312
FHL
Probing under general anesthesia
70.6
6.4
7
*
S01EX03, ,
ATC
3.0
6.3
27
92
XCK00
NOMESCO Finland
Perimetry
2.4
6.3
45
200
S01AA30
ATC
combinations of different antibiotics; ophthalmic
11.2
6.3
11
10
3743B
ICD-9 Finland
Other disorders of eyelids, Ptosis of eyelid[BLEPHAROCHALASIS ET DERMATOCHALASIS]
+∞
6.3
6
*
CCD99
NOMESCO Finland
Other reconstructive operation on lacrimal apparatus
+∞
6.3
6
*
ZXD20
NOMESCO Finland
Day surgery
1.9
6.2
79
440
H00.1
ICD-10 Finland
Chalazion
5.3
6.0
17
33

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
131
522
2.93
23.72
2.4
1.6
—
—
—
0
0
165
1053
1.78
8.54
4.7
3.8
—
—
—
0
0
95
523
1.97
7.75
1.7
1.4
—
—
—
0
0
235
1785
1.52
5.65
4.2
3.8
5.63
5.95
ph
—
8
101
321
2626
1.48
5.24
8.7
8.8
3.95
4.19
e9/l
1.20
272
2312
159
1129
1.56
5.12
2.3
2.2
—
—
—
0
0
103
667
1.66
4.84
2.1
1.9
—
—
—
0
0
516
4711
1.70
4.73
21.3
18.4
139.55
139.59
mmol/l
0.15
504
4569
516
4721
1.68
4.56
21.3
18.6
4.06
3.98
mmol/l
0.50
501
4571
508
4635
1.64
4.48
15.8
15.0
—
—
—
0
0
195
1482
1.47
4.45
2.3
2.3
—
—
—
0
0
496
4511
1.58
4.30
17.7
15.3
24.02
25.00
mg/l
0.28
418
3584
243
1939
1.43
4.24
4.4
3.9
42.00
58.08
ng/l
0.37
185
1455
533
4940
1.73
4.22
26.2
22.8
91.68
91.38
fl
0.72
527
4839
140
1005
1.51
4.21
5.4
4.5
1.02
1.02
kg/l
1.48
18
155
533
4941
1.72
4.20
26.3
22.8
6.57
6.77
e9/l
1.69
522
4775
533
4941
1.72
4.20
26.2
22.7
30.45
30.27
pg
1.38
527
4839
533
4942
1.72
4.18
26.3
22.9
4.38
4.39
e12/l
0.16
524
4778
226
1783
1.43
4.18
2.3
2.2
—
—
—
0
0
533
4944
1.72
4.15
26.3
23.0
132.28
132.07
g/l
0.13
528
4840
516
4751
1.63
4.09
11.6
10.7
22.74
24.03
u/l
1.45
493
4540
532
4940
1.70
4.02
26.4
22.9
242.00
248.81
e9/l
1.69
523
4788
532
4940
1.70
4.02
26.3
22.9
39.44
39.22
%
0.35
507
4564
259
2126
1.38
3.70
4.4
4.5
34.87
34.95
g/l
0.09
237
1968
367
3198
1.38
3.58
5.9
5.0
12.57
2703.16
e6/l
—
7
55
384
3387
1.37
3.38
4.6
4.2
12.36
14.17
mm/h
2.24
358
3084
403
3590
1.38
3.28
7.6
7.3
76.23
79.73
u/l
0.42
380
3325
132
982
1.44
3.26
2.5
3.0
2.44
2.47
mmol/l
1.36
114
870
63
400
1.64
3.21
4.3
3.6
—
—
—
0
0
256
2146
1.34
3.03
2.6
2.6
—
—
—
0
0
272
2301
1.33
3.02
4.7
4.1
0.00
0.01
estimate
0.50
38
417
268
2267
1.33
2.96
4.6
4.1
0.00
0.00
estimate
0.50
45
477
366
3243
1.33
2.90
4.7
4.1
—
—
—
0
0
269
2282
1.32
2.89
5.8
5.4
0.00
0.00
estimate
0.50
40
425
322
2802
1.32
2.89
4.8
4.6
6.66
6.79
mmol/l
0.59
306
2623
267
2274
1.31
2.75
6.1
5.8
1.21
1.22
mmol/l
0.34
241
2045
471
4350
1.39
2.75
4.8
4.6
4.55
4.61
mmol/l
0.58
432
3928
389
3491
1.33
2.74
4.7
4.0
15.03
15.00
pmol/l
0.08
353
3110
455
4186
1.36
2.66
5.9
4.9
2.05
1.99
mu/l
0.33
413
3747
481
4467
1.39
2.64
5.5
5.1
2.61
2.67
mmol/l
0.80
439
4016
183
1487
1.33
2.60
2.1
2.0
137.79
246.75
u/l
1.31
167
1406
270
2317
1.30
2.59
7.2
5.3
0.19
0.19
e9/l
0.20
228
2028
207
1723
1.31
2.46
2.6
3.4
2.35
2.36
mmol/l
0.60
178
1479
233
1971
1.30
2.46
2.2
2.3
80.42
79.22
nmol/l
0.28
206
1716
473
4401
1.36
2.40
5.1
4.8
5.96
6.01
mmol/l
0.48
429
3916
266
2295
1.29
2.39
7.2
5.2
1.77
1.89
e9/l
0.83
231
2029
455
4211
1.34
2.38
6.2
6.2
40.12
40.43
mmol/mol
0.35
415
3842
10
33
3.06
2.36
1.4
1.2
—
—
—
0
0
26
140
1.90
2.35
18.7
9.3
—
—
—
0
0
182
1499
1.31
2.32
3.0
3.8
7.40
7.40
ph
0.05
25
279
66
460
1.49
2.29
2.7
2.5
3.21
7.02
ug/l
3.69
55
395
284
2482
1.27
2.27
6.3
6.6
1.22
1.22
mmol/l
0.19
243
2105
25
137
1.86
2.16
1.3
1.2
—
—
—
0
0
129
1022
1.33
2.15
5.3
5.1
3.11
2.86
ug/l
0.10
117
890
236
2030
1.27
2.11
2.1
2.1
96.28
94.53
pmol/l
0.19
113
1003
358
3235
1.27
2.11
5.2
4.6
—
—
—
0
0
82
609
1.40
2.05
5.4
5.9
104.52
104.03
mmol/l
0.56
82
609
242
2095
1.26
2.03
7.2
5.7
—
—
—
0
0
50
338
1.52
2.02
1.1
1.2
—
—
—
0
0
153
1255
1.29
1.98
5.2
4.4
0.00
0.00
estimate
0.50
37
422
189
1606
1.26
1.83
3.2
3.1
1553.78
1628.46
ng/l
0.09
172
1371
254
2232
1.24
1.82
7.3
5.1
0.58
0.59
e9/l
0.41
215
1932
137
1120
1.29
1.81
7.4
6.6
—
—
—
0
0
37
553
0.65
1.81
2.4
4.1
7.50
29.62
ug/l
0.89
28
463
202
1734
1.25
1.79
3.6
3.5
—
—
—
0
0
115
921
1.31
1.78
1.2
1.2
2.64
1.55
u/ml
0.36
29
233
254
2238
1.23
1.77
7.2
5.1
0.04
0.04
e9/l
0.33
216
1939
244
2142
1.24
1.75
7.5
5.2
57.34
58.30
%
0.62
223
1997
6
18
3.36
1.75
4.5
2.4
32.23
22.71
mu/l
—
6
18
266
2361
1.23
1.71
24.7
16.4
1.34
1.29
inr
0.31
65
673
246
2166
1.23
1.71
7.7
5.4
27.63
26.77
%
0.55
224
2020
29
181
1.63
1.66
2.9
3.0
—
—
—
0
0
459
4323
1.27
1.66
4.8
4.5
1.49
1.51
mmol/l
0.22
415
3887
411
3825
1.24
1.64
20.5
18.7
15.73
15.20
%
0.82
405
3749
444
4172
1.25
1.60
4.3
4.1
1.29
1.26
mmol/l
0.40
399
3716
173
1481
1.24
1.54
4.5
4.2
—
—
—
0
0
239
2122
1.21
1.48
7.9
5.5
8.74
8.62
%
0.21
219
1975
279
2516
1.20
1.47
6.3
6.0
11.65
11.71
umol/l
0.03
261
2374
39
271
1.47
1.43
1.2
1.3
—
—
—
0
0
23
141
1.66
1.43
1.4
1.4
297.00
285.77
ug/g
0.10
14
80
74
575
1.33
1.43
2.9
2.9
0.78
0.82
ug/l
0.15
52
375
136
1143
1.25
1.43
2.7
2.6
4678.40
8949.50
umol/l
0.64
117
974
70
543
1.33
1.38
1.3
1.3
—
—
—
0
0
6
23
2.62
1.37
2.8
3.7
—
—
—
0
0
236
2110
1.20
1.33
7.6
5.2
3.02
2.77
%
0.96
217
1955
98
801
1.27
1.31
1.4
1.3
2.34
2.56
g/l
0.64
56
453
22
137
1.63
1.31
3.4
3.6
—
—
—
0
0
45
331
1.39
1.25
4.1
5.8
—
—
—
0
0
5
19
2.64
1.22
1.6
1.7
14.34
5.18
umol/l
—
5
14
90
736
1.26
1.21
1.4
1.3
14.88
35.70
iu/ml
3.83
28
235
67
528
1.30
1.20
1.3
1.3
818.46
446.56
titre
0.42
13
122
194
1719
1.19
1.19
3.8
3.8
95.26
96.03
e6/l
0.01
130
1262
36
258
1.42
1.16
2.8
2.5
—
—
—
0
0
156
1364
1.19
1.11
4.6
4.0
—
—
—
0
0
117
1364
0.82
1.11
3.1
3.1
—
—
—
0
0
19
120
1.60
1.09
1.3
1.1
—
—
—
0
0
70
563
1.28
1.09
5.6
7.4
1.23
1.36
mmol/l
0.09
60
443
226
2049
1.17
1.04
7.8
5.3
0.67
0.67
%
0.08
205
1894
20
298
0.66
1.03
2.5
3.8
—
—
—
0
0
157
1382
1.18
1.03
3.0
3.2
0.42
0.47
e6/l
0.11
120
1067
33
241
1.39
0.99
6.9
10.7
—
—
—
0
0
21
140
1.52
0.98
1.4
1.6
—
—
—
0
0
60
482
1.27
0.96
1.9
2.0
92.12
135.84
ug/g
1.20
47
381
151
1334
1.18
0.95
2.9
3.2
—
—
—
0
0
122
1059
1.19
0.94
2.1
2.7
6.11
6.56
e6/l
0.14
109
967
6
28
2.15
0.91
1.0
1.2
—
—
—
0
0
18
266
0.67
0.91
3.3
3.1
0.05
0.26
e6/l
2.98
18
260
6
29
2.08
0.89
1.3
1.7
—
—
—
0
0
17
111
1.55
0.88
3.9
3.6
22.96
28.63
mg/l
—
9
69
10
167
0.59
0.86
3.0
4.5
—
—
—
0
0
8
44
1.83
0.86
1.5
1.3
—
—
—
0
0
31
232
1.35
0.83
7.6
3.3
24.20
24.20
mmol/l
0.00
31
223
8
47
1.71
0.81
3.0
3.1
—
—
—
0
0
53
430
1.26
0.80
2.4
2.3
41.20
31.90
u/l
0.73
44
351
110
1252
0.85
0.80
3.7
3.8
—
—
—
0
0
154
1384
1.15
0.78
3.1
3.4
28.17
31.83
u/l
1.31
144
1312
0
27
0.00
0.77
0.0
2.3
—
40.06
—
0
17
10
59
1.71
0.76
1.1
1.1
—
—
—
0
0
5
24
2.09
0.74
2.6
1.1
6.36
5.57
ug/l
—
5
19
34
264
1.31
0.73
1.1
1.2
90.24
148.94
iu/ml
—
9
94
5
25
2.01
0.73
1.2
1.2
—
—
—
0
0
120
1065
1.16
0.72
1.7
1.8
1303.46
1200.04
nmol/l
0.60
93
777
26
194
1.36
0.72
4.8
4.2
—
—
—
0
0
13
84
1.56
0.72
1.3
1.2
—
—
—
0
0
141
1269
1.15
0.70
2.2
2.2
3.00
3.21
mg/l
0.46
118
1068
10
61
1.65
0.69
1.3
1.4
—
—
—
0
0
5
27
1.86
0.68
1.0
1.2
—
—
—
0
0
5
28
1.79
0.66
2.0
2.4
—
—
—
0
0
33
260
1.28
0.65
1.3
1.3
—
—
—
0
0
82
713
1.17
0.65
1.4
1.2
1.98
13.97
u/ml
3.75
32
254
209
1939
1.12
0.65
2.8
2.7
123.03
129.69
ug/l
0.20
191
1743
33
410
0.79
0.61
4.2
4.1
—
—
—
0
0
51
431
1.20
0.57
5.2
6.0
1.59
1.47
mmol/l
0.10
51
417
159
1463
1.12
0.57
2.6
2.5
64.89
113.80
u/l
0.42
145
1335
57
488
1.19
0.55
5.7
3.3
5.73
5.78
kpa
0.16
57
469
105
944
1.14
0.55
5.4
4.1
307.03
260.70
ng/l
0.08
90
790
6
38
1.58
0.54
3.3
1.3
12.65
9.43
%
—
6
38
59
508
1.18
0.54
5.0
4.2
—
—
—
0
0
11
74
1.50
0.53
1.3
1.4
—
—
—
0
0
6
98
0.61
0.52
2.7
2.8
—
—
—
0
0
9
132
0.68
0.52
1.4
1.3
—
—
—
0
0
15
109
1.39
0.51
2.6
2.7
—
—
—
0
0
11
75
1.48
0.51
1.7
1.4
33.28
32.90
g/l
0.03
11
66
56
485
1.17
0.49
5.8
3.3
1.73
2.01
mmol/l
0.23
51
390
52
601
0.85
0.49
4.6
2.3
1.70
1.81
%
0.49
41
527
7
108
0.64
0.49
2.0
3.4
—
—
—
0
0
46
394
1.18
0.46
9.1
7.2
—
—
—
0
0
11
77
1.44
0.46
1.3
1.4
—
—
—
0
0
14
103
1.37
0.45
2.1
1.5
4.45
4.56
iu/l
—
8
26
7
51
1.38
0.44
1.7
1.2
—
—
—
0
0
19
148
1.29
0.44
1.2
1.2
3.20
2.33
u/ml
—
5
12
11
78
1.42
0.43
1.3
1.4
—
—
—
0
0
11
78
1.42
0.43
1.3
1.4
—
—
—
0
0
11
78
1.42
0.43
1.3
1.4
—
—
—
0
0
8
56
1.43
0.42
1.1
3.7
—
—
—
0
0
8
58
1.38
0.41
15.9
6.2
7.18
7.13
mmol/l
—
8
44
5
33
1.52
0.41
1.2
1.0
1.36
1.49
nmol/l
—
5
26
0
16
0.00
0.41
0.0
1.3
—
41.21
—
0
7
0
17
0.00
0.40
0.0
2.9
—
37247.35
—
0
17
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.8
—
29.90
—
0
10
107
985
1.11
0.39
2.1
1.6
1.67
1.30
mg/l
0.37
81
771
0
19
0.00
0.39
0.0
1.3
—
45.19
—
0
8
38
327
1.17
0.38
1.6
1.4
—
—
—
0
0
151
1417
1.09
0.37
2.8
3.2
546.50
271.27
mg/l
0.22
82
887
14
107
1.32
0.37
1.4
1.5
31.82
24.23
iu/l
0.32
14
95
160
1506
1.09
0.37
3.1
3.4
26.87
54.93
e6/l
1.24
121
1178
5
37
1.35
0.37
1.2
1.0
—
—
—
0
0
9
71
1.27
0.36
1.9
1.3
9.32
11.39
u/l
—
9
59
47
414
1.15
0.36
1.3
1.4
—
—
—
0
0
32
373
0.85
0.36
1.4
1.4
—
—
—
0
0
10
73
1.38
0.34
1.2
3.1
—
—
—
0
0
6
45
1.34
0.34
2.0
2.3
—
—
—
0
0
21
253
0.82
0.33
1.3
1.3
—
—
—
0
0
6
89
0.67
0.33
1.5
1.3
68473.33
215.53
e6/l
—
6
73
6
89
0.67
0.33
1.5
1.2
33.17
16.75
e6/l
—
6
71
7
97
0.72
0.31
2.4
1.6
—
—
—
0
0
7
55
1.28
0.30
1.0
1.2
—
—
—
0
0
38
429
0.88
0.29
1.4
1.4
—
—
—
0
0
17
206
0.82
0.29
1.6
2.0
—
—
—
0
0
8
62
1.29
0.28
1.0
1.1
—
—
—
0
0
8
62
1.29
0.28
1.0
1.0
—
—
—
0
0
207
1989
1.06
0.27
11.3
9.5
0.00
0.00
e9/l
0.78
170
1636
9
120
0.75
0.27
1.1
1.7
—
—
—
0
0
9
121
0.74
0.27
1.1
4.0
—
—
—
0
0
8
65
1.23
0.27
2.0
1.5
—
—
—
0
0
8
65
1.23
0.27
1.6
1.3
—
—
—
0
0
21
245
0.85
0.25
1.2
1.3
—
—
—
0
0
23
198
1.17
0.25
1.1
1.2
—
—
—
0
0
16
133
1.21
0.24
1.8
3.3
7.44
7.42
ph
1.24
11
115
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
5
40
1.25
0.22
1.0
1.6
—
—
—
0
0
5
41
1.22
0.22
3.2
2.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
11
134
0.82
0.21
2.5
2.8
—
—
—
0
0
122
1165
1.06
0.20
1.6
1.6
1.36
1.33
mmol/l
0.16
106
960
34
375
0.90
0.20
1.3
2.5
—
—
—
0
0
6
49
1.23
0.20
2.2
1.2
—
—
—
0
0
6
50
1.20
0.19
1.0
1.1
—
—
—
0
0
13
154
0.84
0.19
2.5
1.8
—
—
—
0
0
82
775
1.07
0.19
3.3
3.0
3.06
3.03
e6/l
0.01
37
423
6
52
1.16
0.19
1.2
1.2
—
—
—
0
0
120
1252
0.95
0.18
1.5
1.6
22.46
20.76
nmol/l
0.54
104
1036
41
445
0.92
0.18
4.2
2.5
69.80
69.28
e9/l
0.04
35
353
117
1121
1.05
0.18
1.7
1.7
424.72
12914352.94
pmol/l
0.80
92
906
7
59
1.19
0.18
2.4
3.0
—
—
—
0
0
7
62
1.13
0.17
1.0
1.1
—
—
—
0
0
5
66
0.76
0.17
1.0
1.2
—
—
—
0
0
151
1461
1.04
0.16
2.9
3.1
6.05
6.88
mmol/l
1.73
128
1220
11
92
1.20
0.16
2.5
1.7
—
—
—
0
0
35
379
0.92
0.15
3.5
4.0
0.00
0.12
%
3.34
11
128
33
358
0.92
0.15
3.7
4.1
0.00
0.08
%
—
9
106
66
626
1.06
0.14
1.1
1.2
—
—
—
0
0
9
83
1.09
0.14
4.1
2.7
4.25
4.50
e9/l
—
9
83
7
89
0.78
0.14
2.3
2.4
—
—
—
0
0
10
84
1.19
0.14
1.2
1.3
—
—
—
0
0
30
276
1.09
0.14
3.6
3.1
24.95
24.90
mmol/l
0.03
30
267
22
199
1.11
0.13
1.2
1.5
—
—
—
0
0
38
407
0.93
0.13
3.5
3.9
0.50
0.91
%
1.02
14
155
13
113
1.15
0.13
1.0
1.1
—
—
—
0
0
13
113
1.15
0.13
1.3
1.1
—
—
—
0
0
40
427
0.93
0.13
2.7
3.8
1.21
1.23
mmol/l
1.54
34
368
108
1046
1.04
0.11
2.2
3.1
536.88
523.06
mosm/kgh2o
0.31
88
903
24
259
0.92
0.10
2.0
1.5
1.00
1.52
g/l
0.96
19
237
5
44
1.14
0.10
1.0
1.0
—
—
—
0
0
154
1507
1.03
0.09
3.5
3.8
7.13
8.03
mg/mmol
0.09
86
940
46
439
1.05
0.09
2.3
2.7
67.11
66.61
g/l
0.19
40
389
111
1082
1.03
0.09
1.3
1.3
—
—
—
0
0
6
58
1.03
0.08
1.0
1.3
—
—
—
0
0
7
66
1.06
0.08
4.9
2.9
—
—
—
0
0
49
510
0.96
0.08
4.3
2.6
8.61
9.79
umol/l
0.11
37
434
6
70
0.86
0.07
1.2
1.4
—
—
—
0
0
8
75
1.07
0.07
1.3
1.7
234.62
315.19
mu/l
—
8
70
9
87
1.04
0.07
6.2
3.0
56.89
60.36
%
—
9
87
34
356
0.95
0.06
3.4
4.0
0.18
0.49
%
1.38
11
125
9
101
0.89
0.06
1.7
1.3
564.89
498.43
mg/l
—
9
96
52
503
1.04
0.06
1.3
1.6
—
—
—
0
0
25
237
1.06
0.05
4.0
3.7
—
—
—
0
0
19
178
1.07
0.05
1.9
1.5
—
—
—
0
0
33
344
0.96
0.05
1.6
1.5
—
—
—
0
0
66
676
0.97
0.05
1.7
2.4
23.95
21.11
%
0.64
53
563
10
107
0.93
0.02
1.8
3.5
1.28
2.85
mmol/l
—
5
66
14
133
1.05
0.01
1.3
1.1
—
—
—
0
0
77
778
0.99
0.01
1.7
2.4
13.13
12.20
umol/l
0.60
69
706
274
2731
1.01
0.01
3.9
3.1
46.52
49.49
u/l
0.19
244
2484
21
216
0.97
0.00
1.2
1.8
1.43
1.55
g/l
0.27
16
189
50
506
0.99
0.00
1.1
1.3
—
—
—
0
0
42
423
0.99
0.00
1.3
1.6
—
—
—
0
0
45
447
1.01
0.00
2.2
2.0
0.23
0.20
g/l
1.49
39
415
35
351
1.00
0.00
4.4
3.1
—
—
—
0
0
72
719
1.00
0.00
1.6
2.4
2.31
2.31
g/l
0.02
66
646
5
56
0.89
0.00
1.2
1.1
—
—
—
0
0
5
50
1.00
0.00
2.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
7.63
—
0
8
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
73
0.96
-0.00
1.3
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
18.28
—
0
8
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
-0.00
2.6
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
9.3
—
—
—
0
0
5
58
0.86
-0.00
2.2
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
18.70
—
0
7
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
23
230
1.00
-0.00
1.4
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
9.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_LACRIMINFLAMCHRON and mortality.

Females

Parameter HR [95% CI] p-value
H7_LACRIMINFLAMCHRON 0.99 [0.89, 1.11] 0.858
Birth year 0.995 [0.99, 1.0] 0.231

During the follow-up period (1.1.1998 — 31.12.2019), 939 out of 2779 females with H7_LACRIMINFLAMCHRON died.

Males

Parameter HR [95% CI] p-value
H7_LACRIMINFLAMCHRON 0.993 [0.84, 1.18] 0.931
Birth year 0.991 [0.98, 1.0] 0.127

During the follow-up period (1.1.1998 — 31.12.2019), 290 out of 989 males with H7_LACRIMINFLAMCHRON died.

Mortality risk

Mortality risk for people of age

years, who have H7_LACRIMINFLAMCHRON.

N-year risk Females Males
1 0.102% 0.225%
5 0.573% 1.344%
10 1.423% 3.252%
15 2.833% 6.231%
20 5.208% 10.524%

Relationships between endpoints

↥

Index endpoint: H7_LACRIMINFLAMCHRON – Inflammation of lacrimal passages (chronic)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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