lens disease: A disease involving the lens of camera-type eye. [database_cross_reference: MONDO:DesignPattern]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
551 |
4. Check minimum number of eventsNone |
551 |
5. Include endpointsNone |
551 |
6. Filter based on genotype QC (FinnGen only) |
551 |
Control definitions (FinnGen only)
- Control exclude
- H7_LENS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- H27
- Name in latin
- Dislocatio lentis
Dislocation of lens
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5172 | 2808 | 2333 |
| Only index persons | 4530 | 2530 | 2000 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.07 |
| Only index persons | 0.09 | 0.09 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 75.35 | 79.10 | 70.85 |
| Only index persons | 75.57 | 79.29 | 70.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 551 | 255 | 296 |
| Unadjusted period prevalence (%) | 0.11 | 0.09 | 0.13 |
| Median age at first event (years) | 73.94 | 76.52 | 71.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 496
- Matched controls
- 4969
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
282.7
323.0
332
35
Z96.1
ICD-10 Finland
Presence of intraocular lens
245.3
323.0
372
59
H27.1
ICD-10 Finland
Dislocation of lens
4503599627370496.0
323.0
463
*
H25.1
ICD-10 Finland
Senile nuclear cataract
137.2
263.9
268
42
WX140
NOMESCO Finland
Parabulbar anesthesy
104.4
215.5
228
40
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
23.8
203.6
399
724
S01ED51
ATC
timolol, combinations; ophthalmic
28.6
150.8
214
128
H26.4
ICD-10 Finland
After-cataract
441.1
135.7
130
*
H25.8
ICD-10 Finland
Other senile cataract
297.9
117.3
115
5
CJB10
NOMESCO Finland
Laser discission of secondary cataract
173.0
117.0
119
9
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
1198.4
103.0
97
*
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
+∞
100.5
93
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
161.7
100.4
103
8
CKD60
NOMESCO Finland
Anterior vitrectomy
588.2
100.2
96
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
53.6
86.8
103
24
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
95.9
86.6
94
12
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
442.4
78.1
76
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
11.9
75.9
151
176
S01BC05
ATC
ketorolac; ophthalmic
44.2
73.9
91
25
H33.0
ICD-10 Finland
Retinal detachment with retinal break
51.0
71.0
85
20
114
Kela drug reimbursment
Glaucoma
9.9
68.2
150
207
S01EC01
ATC
acetazolamide; systemic
51.1
65.2
78
18
CJF15
NOMESCO Finland
Secondary implantation of skleral fixed artificial lens in posterior chamber
+∞
65.0
61
*
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
25.5
62.8
89
42
S01EE01
ATC
latanoprost; ophthalmic
12.3
62.1
119
124
S01ED01
ATC
timolol; ophthalmic
18.3
61.0
97
65
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
31.1
59.1
79
30
ZXA00
NOMESCO Finland
Right side
4.9
52.7
222
701
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.3
50.6
290
1224
XCH00
NOMESCO Finland
Eye pressure measurement
26.9
50.5
70
30
CJF45
NOMESCO Finland
Removal and implantation of artificial lens in anterior chamber with iridectomy or iridotomy
526.6
49.2
48
*
ZXA05
NOMESCO Finland
Left side
4.8
48.9
208
652
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
10.0
46.2
97
117
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
12.6
45.8
85
80
S01EA03
ATC
apraclonidine; ophthalmic
132.4
45.6
48
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
105.9
44.6
48
5
XCK10
NOMESCO Finland
Photography of fundus of eye
6.8
43.0
118
216
H27.0
ICD-10 Finland
Aphakia
+∞
42.3
40
*
CJF20
NOMESCO Finland
Removal of artificial lens
+∞
42.3
40
*
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
442.2
41.8
41
*
S01EC04
ATC
brinzolamide; ophthalmic
14.1
41.7
73
60
H40.0
ICD-10 Finland
Glaucoma suspect
9.6
41.6
89
110
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
78.0
38.6
43
6
XCK00
NOMESCO Finland
Perimetry
8.7
37.8
86
117
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.3
36.6
125
296
WX002
NOMESCO Finland
Sedation and analgesia
4.3
35.7
155
470
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
371.8
35.4
35
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
11.9
34.6
65
62
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
99.7
34.2
37
*
CJG40
NOMESCO Finland
Extraction of dislocated lens with implantation of artificial scleral fixed lens in posterior chamber and iridectomy or iridotomy
+∞
32.6
31
*
H25.0
ICD-10 Finland
Senile incipient cataract
17.4
31.0
49
31
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
60.6
29.5
34
6
CJG15
NOMESCO Finland
Extraction of dislocated lens with implantation of artificial lens in anterior chamber and iridectomy or iridotomy
308.8
29.1
29
*
H26.02
ICD-10 Finland
Presenil cataract
308.8
29.1
29
*
H26.2
ICD-10 Finland
Complicated cataract
+∞
28.4
27
*
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
285.5
27.0
27
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
12.2
26.7
49
44
CJF00
NOMESCO Finland
Secondary implantation of artificial lens in anterior chamber
+∞
26.3
25
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
42.6
26.1
32
8
Q87.4
ICD-10 Finland
Marfan syndrome
273.9
25.9
26
*
S01BC03
ATC
diclofenac; ophthalmic
15.3
24.8
41
29
H43.1
ICD-10 Finland
Vitreous haemorrhage
17.8
24.4
38
23
S01EE05
ATC
tafluprost; ophthalmic
10.3
24.1
48
51
3793B
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[DISLOCATIO LENTIS]
+∞
23.1
22
*
S01AX11
ATC
[U] ofloxacin; ophthalmic
9.3
22.4
47
55
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
11.4
22.3
42
40
37870
ICD-8 Finland
Other diseases of eye, Subluxatio et luxatio lentis
+∞
22.0
21
*
3661A
ICD-9 Finland
Cataract, Senile cataract
+∞
22.0
21
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
83.9
21.9
24
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
83.9
21.9
24
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
8.0
21.8
50
68
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
7.5
21.6
52
76
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
+∞
21.0
20
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
218.6
20.7
21
*
ZXA10
NOMESCO Finland
Bilateral
3.7
20.1
97
307
H35.36
ICD-10 Finland
Macular cyst
76.6
19.8
22
*
CA1TM
NOMESCO Finland
Calculation of intraocular lens power
207.7
19.7
20
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
207.7
19.7
20
*
CHC05
NOMESCO Finland
Iridotomy
17.6
19.4
30
18
CG2T4
NOMESCO Finland
Topography assessment of cornea
57.3
19.1
22
*
S01EC03
ATC
dorzolamide; ophthalmic
16.7
19.0
30
19
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
11.7
19.0
35
32
CJD30
NOMESCO Finland
Pars plana lensectomy
+∞
18.9
18
*
3793C
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[PSEUDOPHAKIA]
196.9
18.7
19
*
S01EX03
ATC
NA
9.9
18.4
37
40
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
+∞
16.8
16
*
3663A
ICD-9 Finland
Cataract secondary to ocular disorders
+∞
16.8
16
*
CKC70
NOMESCO Finland
Circular buckling of sclera
93.2
16.7
18
*
CJE15
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in anterior chamber and iridectomy or iridotomy
175.5
16.6
17
*
S01EE04
ATC
travoprost; ophthalmic
10.9
16.4
31
30
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
49.2
16.1
19
*
CS494
NOMESCO Finland
Other visual field testing
13.5
15.8
27
21
3660C
ICD-9 Finland
Cataract, Infantile, juvenile and presenile cataract[CATARACTA PRAESENILIS]
+∞
15.7
15
*
CJW99
NOMESCO Finland
Other operation on lens
+∞
15.7
15
*
CKC30
NOMESCO Finland
Cryopexy of detached retina
87.8
15.6
17
*
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
164.8
15.6
16
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
164.8
15.6
16
*
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
29.6
15.3
20
7
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
9.4
15.2
31
35
H40.9
ICD-10 Finland
Glaucoma, unspecified
14.8
14.7
24
17
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
19.8
14.3
21
11
A98
ICPC
Health maint/preventive medicine
2.5
14.3
420
3399
H20.1
ICD-10 Finland
Chronic iridocyclitis
43.8
14.2
17
*
CKC60
NOMESCO Finland
Local buckling of sclera using implant
31.0
14.0
18
6
H33.3
ICD-10 Finland
Retinal breaks without detachment
7.7
13.9
32
44
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
9.2
13.6
28
32
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
77.2
13.6
15
*
H21.0
ICD-10 Finland
Hyphaema
143.6
13.5
14
*
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
6.0
13.4
37
66
S01EB01
ATC
pilocarpine; ophthalmic
21.9
13.4
19
9
S01EE03
ATC
bimatoprost; ophthalmic
7.9
13.4
30
40
N02BE01
ATC
paracetamol; systemic, rectal
2.3
13.1
409
3302
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
51.4
12.9
15
*
J01DB01
ATC
cefalexin; oral
2.1
12.8
368
2845
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
12.7
12.7
22
18
S01FA01
ATC
atropine; ophthalmic
32.9
12.6
16
5
CJF99
NOMESCO Finland
Other operation on artificial lens
+∞
12.5
12
*
CJG99
NOMESCO Finland
Other operation on dislocated lens
+∞
12.5
12
*
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
25.0
12.5
17
7
Z94.7
ICD-10 Finland
Corneal transplant status
133.1
12.5
13
*
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
5.0
11.9
38
81
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
66.5
11.6
13
*
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
7.0
11.6
28
42
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
11.5
11
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
+∞
11.5
11
*
CJE99
NOMESCO Finland
Other extracapsular cataract operation using phakoemulsification technique
+∞
11.5
11
*
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
122.6
11.5
12
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.3
10.9
118
599
WX199
NOMESCO Finland
Other local analgesia
8.5
10.9
23
28
A02BC02
ATC
pantoprazole; systemic
1.9
10.9
305
2257
SPAT1153
SPAT
Removal of sutures
2.1
10.7
154
887
WX110
NOMESCO Finland
Local anesthesy
1.9
10.5
276
1984
3639
FHL
Other measure in this category
+∞
10.4
10
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
10.9
10.3
19
18
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
10.0
218
1457
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.4
10.0
93
438
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
9.8
129
714
H27.8
ICD-10 Finland
Other specified disorders of lens
101.8
9.4
10
*
3631
FHL
Setting up an artificial lens as the only procedure
+∞
9.4
9
*
CJF50
NOMESCO Finland
Removal and implantation of artificial lens in posterior chamber
+∞
9.4
9
*
H26.1
ICD-10 Finland
Traumatic cataract
+∞
9.4
9
*
I10
ICD-10 Finland
Essential (primary) hypertension
1.8
9.1
319
2473
H52.1
ICD-10 Finland
Myopia
9.3
9.1
18
20
L28
ICPC
Limited function/disability (L)
2.2
8.9
99
506
S18
ICPC
Laceration/cut
1.8
8.7
190
1256
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
8.6
129
746
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
16.6
8.6
13
8
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
8.5
104
555
CKC12
NOMESCO Finland
Photocoagulation of retina
5.2
8.4
25
50
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
+∞
8.4
8
*
37405
ICD-8 Finland
Cataract, Traumatica
+∞
8.4
8
*
CJF40
NOMESCO Finland
Removal and implantation of artificial lens in anterior chamber
+∞
8.4
8
*
S01ED02
ATC
betaxolol; ophthalmic
9.7
8.3
16
17
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.8
8.3
53
203
CKC20
NOMESCO Finland
Cryopexy of undetached retina
33.9
8.1
10
*
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.8
8.1
190
1281
CHD00
NOMESCO Finland
Laser trabeculoplasty
7.4
8.0
18
25
AA1AD
NOMESCO Finland
CT of head and brain
1.9
8.0
134
804
H25.9
ICD-10 Finland
Senile cataract, unspecified
13.3
7.9
13
10
XCD10
NOMESCO Finland
Electrophysiological examination of eye
8.7
7.9
16
19
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
11.0
7.8
14
13
SPAT1254
SPAT
Administration of medicine
2.2
7.8
87
444
XCD20
NOMESCO Finland
Photoangiography of eye
7.6
7.7
17
23
Z97.4
ICD-10 Finland
Presence of external hearing-aid
3.3
7.7
37
117
H02AB06
ATC
prednisolone; systemic
1.7
7.7
213
1502
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
7.7
168
1103
C07AB07
ATC
bisoprolol; oral
1.7
7.6
260
1949
D07AC01
ATC
betamethasone; topical
1.8
7.5
151
962
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
81.2
7.4
8
*
37403
ICD-8 Finland
Cataract, Complicata
81.2
7.4
8
*
37520
ICD-8 Finland
Glaucoma, Secondary
81.2
7.4
8
*
J01CA04
ATC
amoxicillin; systemic
1.7
7.4
336
2727
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
7.3
173
1159
CFB00
NOMESCO Finland
Suture of conjunctiva
+∞
7.3
7
*
H18.2
ICD-10 Finland
Other corneal oedema
+∞
7.3
7
*
H26.3
ICD-10 Finland
Drug-induced cataract
+∞
7.3
7
*
CJG20
NOMESCO Finland
Extraction of dislocated lens with implantation of artificial lens in posterior chamber
+∞
7.3
7
*
CJC15
NOMESCO Finland
Intracapsular cataract extraction with implantation of artificial lens in anterior chamber and iridectomy or iridotomy
+∞
7.3
7
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
7.3
61
270
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
30.5
7.2
9
*
3643
FHL
Vitrectomy through pars Plana
30.5
7.2
9
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
30.5
7.2
9
*
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
10.2
7.1
13
13
H16.0
ICD-10 Finland
Corneal ulcer
4.2
7.0
25
62
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
17.0
6.8
10
6
SPAT1325
SPAT
Vaccination
1.7
6.7
174
1195
C08CA01
ATC
amlodipine; oral
1.7
6.6
194
1376
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
6.6
81
429
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.5
6.6
50
213
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
3.2
6.6
33
109
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
6.5
86
469
R06.0
ICD-10 Finland
Dyspnoea
1.8
6.5
121
748
H53.9
ICD-10 Finland
Visual disturbance, unspecified
4.8
6.5
20
43
K02.1
ICD-10 Finland
Caries of dentine
1.7
6.4
196
1402
CA1ME
NOMESCO Finland
Ultrasound oculometry
70.7
6.4
7
*
3747
FHL
Combined ablation and vitreous surgery with coagulation
70.7
6.4
7
*
H40.8
ICD-10 Finland
Other glaucoma
70.7
6.4
7
*
3744
FHL
Pericardial identification surgery with coagulation (includes epi- and intrascleral indications and eg Lincoff catheter)
70.7
6.4
7
*
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
8.3
6.4
13
16
S01FA04
ATC
cyclopentolate; ophthalmic
11.2
6.3
11
10
B01AB05
ATC
enoxaparin; parenteral
1.7
6.3
144
948
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
6.3
131
839
R42
ICD-10 Finland
Dizziness and giddiness
1.8
6.3
113
691
H25.2
ICD-10 Finland
Senile cataract, morgagnian type
+∞
6.3
6
*
37401
ICD-8 Finland
Cataract, Praesenilis
+∞
6.3
6
*
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
+∞
6.3
6
*
3642
FHL
Anterior vitrectomy
+∞
6.3
6
*
3628
FHL
Intracapsular cataract surgery and implantation of an artificial lens
+∞
6.3
6
*
37602
ICD-8 Finland
Detachment of retina, Foramen, ruptura retinae
+∞
6.3
6
*
PD5CG
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
27.0
6.2
8
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
27.0
6.2
8
*
H3603, E103
ICD-10 Finland
NA
27.0
6.2
8
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.8
6.2
106
638
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.2
6.1
59
282
SPAT1263
SPAT
Sampling
1.7
6.1
178
1253
TK800
NOMESCO Finland
Hemodialysis
5.3
6.1
17
33
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.8
6.0
103
619
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
488
3741
3.70
23.02
26.2
19.2
139.3
139.5
mmol/l
1.28
471
3621
448
3273
2.99
22.99
21.3
15.7
69.0
72.7
ml/min/173m2
2.64
392
2682
488
3748
3.68
22.80
26.7
19.3
4.0
4.0
mmol/l
0.61
470
3623
493
3885
3.60
20.47
32.2
23.2
239.1
240.7
e9/l
0.19
477
3739
493
3886
3.59
20.44
32.2
23.2
4.3
4.4
e12/l
6.04
475
3728
479
3714
3.24
20.41
12.7
10.3
25.8
24.5
u/l
0.44
452
3539
493
3887
3.59
20.41
32.4
23.4
129.7
132.8
g/l
4.04
484
3785
374
2586
2.39
20.02
4.6
3.8
16.9
14.7
mm/h
1.28
327
2347
400
2865
2.45
19.50
8.3
7.1
83.5
81.7
u/l
0.25
369
2649
171
861
2.43
19.11
1.8
1.7
1021.4
1211.1
nmol/l
1.87
121
625
234
1360
2.25
18.62
3.6
3.1
2785.5
1803.1
ng/l
1.13
207
1189
302
1968
2.19
17.81
5.3
5.9
11.8
12.3
umol/l
0.48
285
1856
302
1977
2.17
17.50
8.8
6.5
1.2
1.2
mmol/l
1.27
246
1660
458
3564
2.70
17.49
23.4
15.9
28.0
28.0
mg/l
0.00
393
2876
122
552
2.56
16.95
31.4
29.0
1.5
1.5
inr
0.02
23
73
259
1648
2.08
15.60
2.3
2.1
93.2
94.7
pmol/l
0.19
142
827
328
2279
2.09
15.52
5.7
4.7
6.8
6.8
mmol/l
0.16
305
2127
230
1413
2.08
15.11
2.4
2.1
80.0
79.7
nmol/l
0.05
193
1224
246
1564
2.04
14.58
4.7
3.9
286.9
62.5
ng/l
0.42
203
1185
411
3148
2.21
14.56
5.6
4.6
2.1
2.0
mu/l
0.25
357
2799
297
2043
1.99
13.84
9.4
8.4
4.4
4.3
e9/l
0.37
266
1751
262
1726
1.99
13.83
5.2
4.5
34.1
34.6
g/l
0.72
240
1579
417
3259
2.16
13.33
6.7
6.1
41.1
40.6
mmol/mol
0.45
369
2960
165
934
2.10
13.17
2.7
2.2
—
—
—
0
0
177
1032
2.05
13.02
2.6
2.1
3.1
3.1
mg/l
0.03
140
847
430
3421
2.18
12.81
5.4
5.0
2.4
2.6
mmol/l
3.00
380
3055
265
1788
1.93
12.72
8.2
5.7
1.2
1.2
mmol/l
0.66
233
1611
216
1377
1.94
12.15
3.4
3.2
2.3
2.4
mmol/l
0.78
172
1162
344
2553
1.93
12.14
4.4
3.7
15.4
15.2
pmol/l
1.10
298
2267
257
1739
1.90
12.02
3.9
3.9
—
—
—
0
0
288
2026
1.88
11.90
3.5
3.0
76.3
53.7
u/l
1.69
258
1846
89
413
2.38
11.44
3.6
3.5
—
—
—
0
0
417
3335
2.04
11.43
4.8
4.5
4.3
4.5
mmol/l
3.52
365
2995
217
1412
1.89
11.27
3.6
2.7
180.3
163.2
ug/l
0.47
187
1263
413
3303
2.01
11.17
4.9
4.4
1.4
1.4
mmol/l
0.35
361
2953
402
3201
1.95
10.80
4.5
3.9
1.3
1.3
mmol/l
0.38
348
2831
82
379
2.37
10.60
2.4
2.3
6.9
6.7
ug/l
0.06
68
320
94
462
2.25
10.53
2.5
3.8
259.8
263.4
u/l
0.06
87
437
420
3415
1.97
10.32
5.3
4.7
6.2
6.1
mmol/l
0.73
358
3042
43
150
3.02
9.67
2.2
1.8
—
—
—
0
0
175
1121
1.82
9.19
2.5
2.5
57.3
56.2
u/l
0.15
163
1031
177
1142
1.81
9.05
2.2
2.0
195.2
295.2
u/l
0.73
169
1055
55
227
2.58
9.04
3.8
4.1
2.1
1.9
mmol/l
0.10
39
171
155
964
1.85
8.92
1.8
1.6
19.4
20.1
nmol/l
0.24
128
822
44
163
2.85
8.90
2.4
1.9
—
—
—
0
0
112
627
1.99
8.85
3.5
2.8
0.8
0.8
mmol/l
0.02
104
579
57
244
2.49
8.69
3.8
4.0
5.0
5.2
kpa
0.72
52
220
145
894
1.84
8.53
3.1
2.8
380.7
13136.3
umol/l
6.13
112
760
209
1447
1.72
8.21
4.2
3.3
—
—
—
0
0
83
434
2.07
7.87
4.7
4.6
33.4
32.6
%
0.21
53
260
111
652
1.88
7.52
3.7
2.3
11.1
12.2
umol/l
1.12
98
598
46
194
2.50
7.24
1.8
1.6
1.4
1.6
g/l
0.71
37
169
376
3096
1.68
7.21
23.5
18.2
36.5
38.4
%
2.14
216
1983
117
715
1.81
6.95
2.0
1.8
—
—
—
0
0
24
72
3.44
6.90
1.2
1.2
—
—
—
0
0
101
593
1.86
6.82
3.8
2.3
2.2
2.3
g/l
0.85
89
546
63
314
2.14
6.75
6.3
3.5
1.2
1.2
mmol/l
0.19
57
266
93
539
1.87
6.52
9.3
4.8
1.0
1.0
mmol/l
0.16
88
489
95
557
1.85
6.42
3.9
2.4
20.6
22.2
%
0.67
81
476
106
650
1.78
6.18
1.6
1.9
29.3
29.9
s
0.68
100
630
91
539
1.82
5.94
7.9
6.7
104.5
104.2
mmol/l
0.22
91
529
232
1757
1.55
5.85
4.3
3.8
0.0
0.0
estimate
0.00
54
309
11
20
5.59
5.82
1.0
1.1
—
—
—
0
0
229
1737
1.55
5.70
5.6
5.2
0.0
0.0
estimate
0.00
54
312
33
134
2.56
5.64
3.2
4.6
48.8
104.2
mg/l
0.62
26
110
33
134
2.56
5.64
3.2
4.6
36.8
44.7
mg/l
0.43
26
111
54
274
2.08
5.54
1.8
1.6
—
—
—
0
0
128
851
1.66
5.53
1.6
1.7
458.7
422.4
pmol/l
0.81
104
678
166
1186
1.57
5.32
4.3
3.7
15.3
10.2
mg/mmol
0.44
95
732
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
35
151
2.41
5.29
3.5
2.3
0.3
0.3
u/ml
0.05
15
77
64
352
1.93
5.25
2.1
2.1
0.2
0.2
g/l
0.46
59
321
160
1142
1.57
5.12
4.2
3.3
0.4
0.6
e6/l
1.27
129
860
225
1737
1.50
4.98
4.3
3.8
0.0
0.0
estimate
0.00
54
311
72
421
1.82
4.89
2.2
2.9
213.7
282.7
ng/l
0.81
65
388
214
1645
1.49
4.79
2.7
2.5
—
—
—
0
0
110
731
1.63
4.71
1.7
1.6
1.6
1.4
mg/l
0.24
86
577
338
2858
1.47
4.59
26.6
19.9
14.1
13.9
%
1.85
327
2783
125
872
1.56
4.35
3.6
3.0
2.5
2.5
mmol/l
0.19
107
749
49
265
1.93
4.24
1.4
1.4
—
—
—
0
0
21
81
2.66
4.02
1.6
1.6
—
—
—
0
0
48
263
1.90
4.01
2.7
2.8
60.7
58.7
ml/min/173m2
0.14
23
117
18
65
2.83
3.89
3.6
2.4
15.1
15.5
%
0.17
12
30
26
114
2.34
3.84
1.3
1.6
—
—
—
0
0
189
1473
1.43
3.75
5.2
5.2
7.4
6.6
ug/l
0.06
166
1300
130
952
1.48
3.55
4.9
4.1
0.0
0.0
estimate
0.00
52
295
50
290
1.80
3.51
1.4
1.9
395.3
369.0
nmol/l
0.35
41
254
13
41
3.22
3.51
2.2
2.3
89.9
89.5
%
0.12
13
41
13
41
3.22
3.51
3.0
2.6
—
—
—
0
0
91
619
1.56
3.51
1.4
1.2
0.8
1.1
u/ml
1.10
26
140
22
94
2.40
3.45
1.4
1.3
—
—
—
0
0
27
127
2.18
3.41
3.1
3.4
0.7
0.8
nmol/l
0.48
21
102
169
1327
1.39
3.12
4.5
4.2
—
—
—
0
0
32
167
1.97
3.11
1.8
1.9
0.7
1.5
ug/l
0.61
24
139
20
86
2.38
3.11
2.5
2.0
123.6
131.0
g/l
0.83
15
60
14
50
2.85
3.11
1.2
1.2
—
—
—
0
0
48
286
1.74
3.10
2.0
1.6
—
—
—
0
0
73
500
1.53
2.74
7.3
6.9
1.5
1.0
mmol/l
0.54
56
394
112
836
1.43
2.74
4.7
3.9
1140.7
287.0
ng/l
0.65
100
724
52
332
1.63
2.63
5.4
3.5
148.4
88.6
ng/l
1.96
41
284
11
38
2.93
2.59
1.3
1.2
—
—
—
0
0
29
157
1.89
2.57
2.8
2.8
10.3
10.1
g/l
0.10
18
137
64
432
1.54
2.57
5.8
3.4
1.3
2.0
mmol/l
0.68
53
340
72
501
1.50
2.52
7.4
6.9
11.0
11.8
kpa
1.03
65
473
72
501
1.50
2.52
7.4
6.9
5.1
5.1
kpa
0.01
67
471
93
682
1.44
2.50
3.5
3.1
1.7
2.7
e6/l
0.58
52
369
7
16
4.42
2.48
1.6
1.8
—
—
—
0
0
56
372
1.56
2.42
2.7
2.7
66.3
65.8
g/l
0.22
48
344
63
430
1.53
2.41
5.3
3.4
5.9
5.8
kpa
0.26
63
418
6
12
5.04
2.40
1.7
1.8
—
—
—
0
0
15
64
2.38
2.40
1.1
1.4
64218.3
20073.5
e6/l
—
10
42
97
722
1.42
2.40
3.5
3.0
0.8
1.3
e6/l
1.57
57
401
67
466
1.50
2.36
3.2
3.9
30.6
24.4
ug/l
0.08
54
399
140
1111
1.35
2.35
2.7
3.1
34.6
32.0
u/l
0.52
130
1061
9
28
3.25
2.31
1.3
1.2
—
—
—
0
0
71
503
1.47
2.29
8.1
8.0
—
—
—
0
0
6
13
4.65
2.27
1.7
1.8
—
—
—
0
0
7
18
3.92
2.26
1.0
1.2
—
—
—
0
0
25
136
1.88
2.21
2.5
2.3
568.2
942.0
ug/l
0.39
25
131
6
14
4.32
2.15
1.0
1.1
—
—
—
0
0
53
359
1.53
2.12
2.4
2.5
31.0
33.4
u/l
0.29
45
308
23
127
1.85
1.97
1.4
1.2
—
—
—
0
0
62
442
1.45
1.95
2.3
2.5
7.7
9.3
umol/l
0.39
53
380
6
16
3.78
1.94
1.2
1.0
—
—
—
0
0
9
33
2.76
1.94
1.3
1.8
—
—
—
0
0
145
1188
1.30
1.93
4.7
4.5
20.2
21.3
%
0.39
70
606
52
359
1.50
1.92
3.5
2.7
4.8
4.5
kpa
0.47
52
351
17
85
2.03
1.92
1.8
1.6
44861.2
13491.4
e6/l
—
9
58
28
166
1.72
1.91
2.8
2.7
3.3
3.6
g/l
0.74
16
125
28
166
1.72
1.91
2.8
2.7
7.4
7.6
g/l
0.29
16
130
28
166
1.72
1.91
2.8
2.7
—
—
—
0
0
7
22
3.21
1.88
1.6
1.8
—
—
—
0
0
22
122
1.84
1.87
1.4
1.7
—
—
—
0
0
23
133
1.76
1.72
2.6
2.6
—
—
—
0
0
26
156
1.70
1.72
3.0
2.8
3.0
3.2
g/l
0.83
16
129
19
105
1.84
1.65
1.3
1.5
245.8
263.3
ug/g
0.13
12
64
23
136
1.72
1.61
1.3
1.2
365.2
200.4
u/ml
0.37
23
125
39
267
1.50
1.53
1.8
1.8
1.9
1.6
%
1.38
31
223
22
131
1.71
1.51
3.3
2.3
37.3
36.5
g/l
0.25
14
118
105
853
1.29
1.48
3.0
3.1
0.6
0.8
ug/l
3.75
74
586
67
511
1.35
1.47
1.7
1.7
—
—
—
0
0
10
45
2.24
1.47
1.4
1.7
—
—
—
0
0
22
136
1.64
1.34
1.1
1.0
—
—
—
0
0
8
34
2.37
1.29
1.5
1.7
—
—
—
0
0
21
130
1.64
1.28
1.8
1.9
40.8
36.7
u/l
0.34
16
113
11
55
2.02
1.28
3.0
2.9
59.5
60.8
%
0.11
11
55
15
85
1.79
1.24
3.8
3.6
39.6
32.3
mg/l
—
9
59
5
20
2.51
1.15
1.0
1.3
7.0
1.6
u/field
—
5
15
8
40
2.01
1.12
1.4
1.6
—
—
—
0
0
8
40
2.01
1.12
1.5
1.7
—
—
—
0
0
11
59
1.88
1.08
1.3
1.1
3.5
13.9
u/ml
—
5
7
22
146
1.53
1.05
4.5
2.8
2.1
1.0
g/l
0.35
14
129
5
22
2.28
1.03
1.0
1.2
—
—
—
0
0
5
22
2.28
1.03
1.0
1.2
—
—
—
0
0
10
53
1.90
1.02
1.5
2.4
—
30.9
—
0
10
12
68
1.78
1.01
2.6
1.7
—
—
—
0
0
9
161
0.55
0.99
1.3
1.7
—
—
—
0
0
31
224
1.41
0.99
3.9
3.1
25.0
25.2
mmol/l
0.06
31
218
5
23
2.18
0.98
3.6
2.3
—
—
—
0
0
10
54
1.87
0.97
1.4
1.8
—
—
—
0
0
10
54
1.87
0.97
1.4
1.6
—
—
—
0
0
91
767
1.22
0.96
4.4
4.3
1.0
1.0
kg/l
0.69
17
118
13
78
1.68
0.92
1.3
1.7
—
—
—
0
0
18
118
1.54
0.92
3.8
2.4
0.0
0.0
g/l
0.00
13
111
6
29
2.08
0.89
1.3
1.5
—
—
—
0
0
6
29
2.08
0.89
1.3
1.8
—
—
—
0
0
63
515
1.25
0.89
1.7
1.7
—
—
—
0
0
8
42
1.92
0.89
1.5
1.6
—
—
—
0
0
8
42
1.92
0.89
1.5
1.6
—
—
—
0
0
8
42
1.92
0.89
1.5
1.6
—
—
—
0
0
8
42
1.92
0.89
1.5
1.7
—
—
—
0
0
8
42
1.92
0.89
1.5
1.6
—
—
—
0
0
8
42
1.92
0.89
1.5
1.6
—
—
—
0
0
15
95
1.60
0.88
1.3
1.2
—
—
—
0
0
15
95
1.60
0.88
1.3
1.2
—
—
—
0
0
6
31
1.95
0.84
1.0
1.4
—
—
—
0
0
18
121
1.50
0.83
3.8
2.4
0.0
0.0
g/l
0.00
13
112
0
25
0.00
0.79
0.0
1.3
—
—
—
0
0
12
74
1.64
0.78
1.2
1.5
—
—
—
0
0
12
75
1.61
0.75
1.3
1.7
—
—
—
0
0
7
41
1.72
0.70
1.0
1.3
—
—
—
0
0
12
77
1.57
0.69
1.5
1.5
—
—
—
0
0
23
170
1.37
0.68
1.0
1.2
213.5
155.5
iu/ml
—
9
60
7
43
1.64
0.67
1.6
1.7
—
—
—
0
0
5
28
1.79
0.66
1.0
1.2
—
—
—
0
0
5
28
1.79
0.66
1.0
1.2
—
—
—
0
0
11
70
1.58
0.65
2.5
1.7
2.8
6.1
iu/l
—
5
23
14
95
1.49
0.64
1.3
1.5
—
—
—
0
0
5
29
1.73
0.64
1.4
1.1
—
—
—
0
0
11
71
1.56
0.62
1.6
1.4
—
—
—
0
0
18
131
1.39
0.60
3.8
2.3
0.0
0.0
g/l
0.50
13
120
35
288
1.23
0.51
3.6
3.0
124.0
127.6
g/l
0.44
35
280
21
162
1.31
0.50
1.3
1.3
—
61.9
—
0
13
17
127
1.35
0.50
1.2
1.3
—
—
—
0
0
7
45
1.56
0.49
1.1
1.4
—
—
—
0
0
42
355
1.20
0.48
1.4
1.4
—
—
—
0
0
7
48
1.46
0.47
2.3
3.9
—
—
—
0
0
16
122
1.32
0.42
1.3
1.5
—
93.3
—
0
6
5
33
1.52
0.41
1.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
5
35
1.43
0.39
1.6
1.2
—
—
—
0
0
6
44
1.37
0.34
1.7
1.3
—
—
—
0
0
36
314
1.16
0.32
1.4
1.4
—
—
—
0
0
7
52
1.35
0.31
1.3
1.4
—
280.7
—
0
21
7
54
1.30
0.30
1.0
1.2
—
—
—
0
0
53
479
1.12
0.29
1.3
1.2
43.5
45.8
iu/ml
0.05
14
145
10
79
1.27
0.22
1.8
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
6
53
1.13
0.18
2.5
1.9
—
—
—
0
0
8
70
1.14
0.16
2.5
2.0
—
—
—
0
0
18
162
1.11
0.12
2.1
1.8
—
—
—
0
0
11
96
1.15
0.10
1.3
1.2
—
—
—
0
0
11
96
1.15
0.10
1.3
1.2
—
—
—
0
0
16
145
1.11
0.09
2.1
1.7
—
—
—
0
0
14
126
1.11
0.09
3.7
3.7
3.8
4.0
mmol/l
1.04
14
115
6
58
1.03
0.08
7.2
3.8
52.7
41.7
u/ml
—
6
58
7
66
1.06
0.08
1.1
1.1
—
—
—
0
0
49
472
1.04
0.07
1.2
1.2
1.8
13.4
u/ml
2.23
18
156
88
874
1.01
0.00
1.6
1.6
1.3
1.3
mmol/l
0.53
72
727
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
114.0
—
0
6
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
98.0
—
0
6
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
0.00
1.4
1.6
—
—
—
0
0
6
60
1.00
0.00
1.5
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
88.2
—
0
6
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
0.00
0.0
1.0
—
148.3
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_LENSDISLOCATIO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LENSDISLOCATIO | 1.052 [0.92, 1.2] | 0.453 |
| Birth year | 0.994 [0.99, 1.0] | 0.142 |
During the follow-up period (1.1.1998 — 31.12.2019), 976 out of 2298 females with H7_LENSDISLOCATIO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LENSDISLOCATIO | 1.095 [0.92, 1.3] | 0.293 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 628 out of 1783 males with H7_LENSDISLOCATIO died.
Mortality risk
Mortality risk for people of age
years, who have H7_LENSDISLOCATIO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.085% | 0.2% |
| 5 | 0.743% | 1.17% |
| 10 | 1.606% | 3.076% |
| 15 | 2.894% | 5.677% |
| 20 | 5.148% | 10.003% |
Relationships between endpoints
↥Index endpoint: H7_LENSDISLOCATIO – Dislocation of lens
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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