No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
170 |
4. Check minimum number of eventsNone |
170 |
5. Include endpointsNone |
170 |
6. Filter based on genotype QC (FinnGen only) |
170 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other/unspecified mastoiditis and related conditions
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1654 | 727 | 908 |
| Only index persons | 1276 | 608 | 668 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 37.17 | 38.88 | 35.47 |
| Only index persons | 33.83 | 36.42 | 31.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 170 | 82 | 88 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 35.16 | 33.07 | 37.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 152
- Matched controls
- 1521
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
38299
ICD-8 Finland
Unspecified otitis media with mastoiditis
+∞
99.1
84
*
H70.9
ICD-10 Finland
Mastoiditis, unspecified
+∞
49.7
45
*
UDC00
NOMESCO Finland
Ear microscopy
17.0
29.2
48
40
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
28.0
26
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
18.1
17
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
14.1
17.5
30
26
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
95.1
15.9
17
*
DC1AD
NOMESCO Finland
Temporalbone CT
+∞
15.9
15
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
+∞
14.8
14
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
13.7
13
*
38399
ICD-8 Finland
Mastoiditis without mention of otitis media, Unspecified
+∞
12.7
12
*
H70.0
ICD-10 Finland
Acute mastoiditis
+∞
10.5
10
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
+∞
10.5
10
*
H70.8
ICD-10 Finland
Other mastoiditis and related conditions
+∞
10.5
10
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
14.7
9.9
16
12
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.0
9.6
91
507
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
9.5
9
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
9.5
9
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
8.9
9.2
19
24
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.1
8.9
61
269
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
53.1
8.8
10
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.6
8.6
43
151
DFF00
NOMESCO Finland
Pure tone audiometry
5.2
8.6
27
61
H66.9
ICD-10 Finland
Otitis media, unspecified
10.4
8.5
16
17
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
+∞
8.4
8
*
H02AB06
ATC
prednisolone; systemic
2.7
8.1
85
484
H65.0
ICD-10 Finland
Acute serous otitis media
84.0
7.5
8
*
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
+∞
7.3
7
*
4151
FHL
Reoperation for chronic otitis media
+∞
7.3
7
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.7
7.3
32
101
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
23.7
6.8
9
*
H02AB04
ATC
methylprednisolone; systemic
3.6
6.7
31
102
UJF32
NOMESCO Finland
Coloscopy
2.7
6.5
50
230
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
72.7
6.5
7
*
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
72.7
6.5
7
*
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
11.7
6.4
11
10
TDA90
NOMESCO Finland
Removal wax from ear
19.0
6.3
9
5
H65.2
ICD-10 Finland
Chronic serous otitis media
+∞
6.3
6
*
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
21
32
7.35
13.53
3.2
3.2
4.8
5.1
kpa
0.89
21
32
41
128
3.90
11.75
5.9
3.6
—
—
—
0
0
30
74
4.71
11.70
13.7
5.9
24.6
25.2
mmol/l
0.42
30
74
32
99
3.75
9.18
4.4
3.6
1.2
1.2
mmol/l
0.28
26
89
18
36
5.47
8.83
1.6
1.4
—
—
—
0
0
16
30
5.78
8.38
2.2
2.5
18.3
16.1
%
—
7
12
64
341
2.41
6.73
4.5
4.1
0.0
0.0
estimate
0.00
28
114
12
21
6.07
6.68
1.9
2.0
91.6
91.1
%
0.11
12
21
12
22
5.79
6.38
3.5
2.5
4.1
4.7
e9/l
0.40
12
22
12
23
5.54
6.10
5.4
3.2
59.9
57.7
%
0.18
12
23
14
33
4.53
5.67
1.3
1.4
—
—
—
0
0
80
502
2.12
5.42
4.1
4.0
—
—
—
0
0
94
639
2.05
5.02
4.0
3.8
0.0
0.0
estimate
0.00
32
117
93
642
1.99
4.63
5.0
5.3
0.0
0.0
estimate
0.00
31
118
15
45
3.56
4.44
3.5
2.6
—
—
—
0
0
93
650
1.95
4.39
4.1
3.9
0.0
0.0
estimate
0.00
32
111
49
282
2.04
3.98
1.7
1.7
379.3
461.3
pmol/l
2.36
34
241
123
963
2.00
3.97
5.5
4.1
14.8
12.3
mm/h
0.80
108
880
59
368
1.92
3.79
4.0
2.8
0.4
0.3
e6/l
0.21
44
275
79
542
1.85
3.78
4.9
3.8
27.8
43.9
ng/l
0.91
62
390
8
12
6.93
3.71
1.5
1.3
—
—
—
0
0
70
472
1.82
3.47
4.1
2.9
—
—
—
0
0
37
206
2.02
3.25
1.9
1.6
—
—
—
0
0
8
15
5.54
3.23
1.5
1.4
—
—
—
0
0
10
29
3.60
3.10
1.4
1.4
—
—
—
0
0
9
21
4.46
3.04
1.4
1.3
—
—
—
0
0
43
265
1.83
2.78
1.6
1.8
2.4
1.3
mg/l
0.34
31
208
5
6
8.54
2.76
1.0
1.2
4.8
1.8
mmol/l
—
5
6
6
10
6.17
2.72
1.2
1.0
—
—
—
0
0
9
24
3.90
2.71
1.4
1.4
—
—
—
0
0
10
32
3.26
2.69
1.4
1.4
—
—
—
0
0
76
559
1.65
2.60
3.4
2.6
152.0
116.0
ug/l
0.70
62
509
5
7
7.31
2.56
1.6
1.6
—
—
—
0
0
5
7
7.31
2.56
1.6
1.6
—
—
—
0
0
6
11
5.61
2.56
1.7
1.7
—
—
—
0
0
6
11
5.61
2.56
1.7
1.7
—
—
—
0
0
6
11
5.61
2.56
1.7
1.7
—
—
—
0
0
6
11
5.61
2.56
1.7
1.7
—
—
—
0
0
41
256
1.79
2.53
2.3
3.2
2.5
2.5
mmol/l
0.62
36
224
6
12
5.14
2.42
1.7
1.7
—
—
—
0
0
6
12
5.14
2.42
1.7
1.7
—
—
—
0
0
7
17
4.25
2.38
1.4
1.5
—
—
—
0
0
5
9
5.68
2.23
1.6
1.7
—
—
—
0
0
5
9
5.68
2.23
1.2
1.2
—
—
—
0
0
5
9
5.68
2.23
1.0
1.2
—
—
—
0
0
48
333
1.62
1.99
2.7
2.0
3.3
3.0
mg/l
0.51
37
292
140
1245
1.71
1.90
4.7
4.6
6.0
6.0
mmol/l
0.02
107
1123
7
22
3.27
1.90
1.6
1.6
—
—
—
0
0
17
87
2.06
1.87
1.5
1.5
—
—
—
0
0
6
17
3.62
1.85
1.5
1.5
—
—
—
0
0
16
81
2.08
1.81
4.0
2.4
4.7
5.0
kpa
0.53
16
74
74
577
1.50
1.81
5.3
4.4
34.4
35.6
g/l
0.78
60
534
53
387
1.54
1.75
2.1
2.1
124.9
232.0
u/l
1.30
44
367
7
24
3.00
1.74
1.4
1.4
—
—
—
0
0
33
218
1.64
1.65
1.7
1.4
—
—
—
0
0
6
20
3.07
1.59
1.5
1.5
—
—
—
0
0
58
440
1.48
1.58
3.0
3.6
2.4
2.4
mmol/l
0.04
52
383
56
423
1.48
1.56
2.7
2.4
51.0
56.9
u/l
0.94
48
388
44
317
1.52
1.53
1.8
1.5
16.7
21.5
nmol/l
1.57
34
263
93
778
1.43
1.50
11.7
9.7
4.4
4.1
e9/l
0.65
80
685
45
328
1.51
1.48
2.1
2.6
11947.7
6484.1
umol/l
0.19
37
273
136
1227
1.54
1.44
21.7
13.4
80.2
81.0
ml/min/173m2
0.16
120
997
140
1273
1.57
1.41
4.7
4.4
4.6
4.6
mmol/l
0.13
112
1169
139
1263
1.55
1.40
4.7
4.4
1.4
1.5
mmol/l
0.96
112
1145
71
575
1.40
1.33
12.8
5.5
1.2
1.2
mmol/l
0.42
62
517
155
1450
1.78
1.32
31.1
21.0
131.8
135.2
g/l
1.74
144
1422
5
18
2.83
1.29
1.4
1.2
—
—
—
0
0
123
1098
1.43
1.28
25.2
17.6
13.9
13.7
%
0.74
111
1077
19
116
1.72
1.28
4.8
3.7
5.9
5.7
kpa
0.34
19
111
10
49
2.11
1.24
1.6
1.7
—
—
—
0
0
22
142
1.63
1.22
1.7
1.6
—
—
—
0
0
28
194
1.53
1.16
2.8
2.1
2.2
2.4
g/l
1.15
23
176
134
1224
1.45
1.16
4.3
3.9
1.3
1.2
mmol/l
0.64
110
1108
76
635
1.36
1.14
11.1
6.1
1.2
1.2
mmol/l
0.66
46
533
10
51
2.02
1.13
1.6
1.8
—
—
—
0
0
8
40
2.05
1.13
2.1
2.2
23.2
24.7
mmol/l
—
8
31
100
874
1.35
1.11
3.3
3.0
72.5
48.6
u/l
0.40
85
828
130
1186
1.41
1.08
21.6
15.3
40.3
39.8
%
0.37
70
848
114
1019
1.36
1.08
9.5
7.4
75.1
79.6
u/l
0.64
100
943
7
33
2.17
1.07
1.9
1.4
—
—
—
0
0
9
45
2.05
1.07
4.9
2.1
—
—
—
0
0
21
139
1.58
1.06
1.7
1.5
—
—
—
0
0
52
414
1.37
1.05
3.9
3.2
1596.9
1288.3
ng/l
0.26
40
354
140
1298
1.45
1.03
5.1
4.9
2.7
2.7
mmol/l
0.17
110
1183
141
1309
1.45
1.03
22.8
14.3
23.2
23.1
mg/l
0.01
127
1033
92
801
1.32
1.02
3.2
2.9
—
—
—
0
0
17
108
1.64
1.01
27.2
5.6
1.8
1.3
mmol/l
0.26
17
100
7
37
1.93
0.95
1.1
1.2
—
—
—
0
0
106
947
1.32
0.95
4.1
4.1
14.8
14.9
pmol/l
0.05
86
848
6
27
2.27
0.94
1.2
1.2
—
—
—
0
0
33
249
1.40
0.91
2.5
1.7
1348.6
1234.9
nmol/l
0.29
16
190
147
1384
1.46
0.90
12.7
10.4
27.4
25.9
u/l
0.46
134
1334
6
31
1.97
0.85
1.0
1.5
—
—
—
0
0
42
335
1.34
0.83
1.7
1.6
1.5
1.3
mmol/l
0.40
22
278
128
1185
1.32
0.82
6.6
5.9
39.8
40.1
mmol/mol
0.13
104
1096
0
25
0.00
0.79
0.0
1.1
—
—
—
0
0
12
75
1.65
0.77
1.8
1.5
—
—
—
0
0
5
26
1.95
0.71
2.0
1.5
—
—
—
0
0
79
699
1.24
0.69
5.9
6.4
9.6
11.8
umol/l
2.27
72
664
141
1335
1.33
0.67
26.3
16.1
139.4
139.6
mmol/l
0.25
129
1292
141
1338
1.32
0.63
26.6
16.2
4.0
4.0
mmol/l
0.15
129
1291
8
49
1.66
0.63
3.1
2.2
—
—
—
0
0
55
472
1.24
0.62
6.1
4.7
2.3
2.1
ug/l
0.08
43
413
6
37
1.64
0.56
1.5
2.1
—
—
—
0
0
27
215
1.30
0.55
1.3
1.2
37.7
35.9
iu/ml
—
7
73
13
94
1.41
0.47
4.4
3.6
111.3
79.4
ng/l
—
7
83
59
528
1.18
0.43
2.5
2.2
82.2
77.3
nmol/l
0.58
49
452
12
160
0.73
0.42
13.6
8.8
—
—
—
0
0
8
59
1.37
0.41
1.1
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
1.0
—
0
7
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
8
60
1.35
0.41
4.5
2.3
—
—
—
0
0
0
17
0.00
0.41
0.0
4.1
—
99.8
—
0
17
10
71
1.43
0.40
4.9
2.6
0.9
1.3
%
—
10
71
143
1383
1.21
0.36
23.4
16.4
79.3
78.0
umol/l
0.26
143
1383
6
41
1.48
0.36
1.5
1.5
—
—
—
0
0
17
136
1.28
0.35
2.3
2.0
—
—
—
0
0
6
44
1.38
0.35
1.7
1.6
—
—
—
0
0
6
45
1.35
0.34
3.0
1.4
—
0.1
—
0
8
48
431
1.16
0.33
2.4
3.2
33.1
31.9
u/l
0.11
42
406
31
273
1.17
0.27
2.6
2.8
0.7
0.7
ug/l
0.12
23
169
122
1176
1.13
0.27
4.8
4.8
1.9
1.9
mu/l
0.18
100
1054
23
199
1.18
0.25
1.3
1.3
24.4
10.8
u/ml
—
7
83
5
38
1.33
0.23
1.0
2.2
92.4
88.6
%
—
5
38
25
220
1.16
0.23
3.9
2.5
2.0
1.0
e6/l
0.30
15
130
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
38.0
—
0
5
0
12
0.00
0.21
0.0
1.0
—
506.2
—
0
5
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
2.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
3.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
3.5
—
—
—
0
0
23
204
1.15
0.19
4.0
2.7
0.3
1.7
e6/l
1.41
11
116
17
147
1.17
0.19
2.4
2.2
—
—
—
0
0
26
284
0.90
0.15
1.2
1.2
0.7
1.1
u/ml
—
8
85
11
128
0.85
0.14
2.7
2.7
28.4
30.7
u/l
0.22
11
106
9
105
0.85
0.13
1.8
1.7
—
—
—
0
0
13
148
0.87
0.13
4.3
5.2
33.8
31.8
%
—
8
89
11
95
1.17
0.12
1.9
2.7
78.8
61.9
ml/min/173m2
—
5
40
36
380
0.93
0.10
4.6
4.1
22.0
21.7
%
0.05
17
181
7
84
0.83
0.07
1.3
1.3
—
—
—
0
0
30
310
0.96
0.03
2.4
2.1
—
—
—
0
0
16
153
1.05
0.01
26.6
6.1
5.3
5.1
kpa
0.41
16
144
16
153
1.05
0.01
26.6
6.1
11.3
11.8
kpa
0.24
16
145
63
622
1.02
0.01
4.8
4.0
—
—
—
0
0
19
183
1.04
0.01
1.6
1.4
—
—
—
0
0
24
246
0.97
0.00
4.1
3.3
261.2
160.6
ng/l
0.18
14
192
52
517
1.01
0.00
2.3
1.9
100.1
94.2
pmol/l
0.46
29
255
0
6
0.00
0.00
0.0
1.5
—
15.8
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
6
62
0.97
0.00
2.0
2.4
36.8
42.5
u/l
—
6
54
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
137.4
—
0
5
0
5
0.00
0.00
0.0
4.6
—
103.4
—
0
5
0
7
0.00
0.00
0.0
6.4
—
225.1
—
0
7
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
1.3
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
1610.3
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint H8_MASTNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have H8_MASTNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: H8_MASTNAS – Other/unspecified mastoiditis and related conditions
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data