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Oral lichen ruber planus, hypothyreosis or thyroxin

K11_ORAL_LICHEN_HYPOT_THYRO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • HYPOT_THYRO_INCL
66417

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

533

6. Filter based on genotype QC (FinnGen only)

533

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF8

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 533 494 39
Unadjusted period prevalence (%) 0.16 0.17 0.02
Median age at first event (years) 65.49 65.40 66.70

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
449
Matched controls
4490
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
+∞
323.0
449
24
H03AA01
ATC
levothyroxine sodium; systemic
863.8
268.2
447
938
EKA10
NOMESCO Finland
Biopsy of cheek
50.6
130.6
157
47
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
12.3
113.4
247
404
SAA03
NOMESCO Finland
Extended examination of mouth
9.2
96.0
351
1259
L43.8
ICD-10 Finland
Other lichen planus
36.0
86.4
112
41
L43.9
ICD-10 Finland
Lichen planus, unspecified
36.5
83.0
107
38
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
22.5
78.5
117
69
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
26.7
67.1
94
44
WZB00
NOMESCO Finland
Telephone receipt or other advice
4.8
51.4
246
907
104
Kela drug reimbursment
Thyroid insufficiency
7.2
48.0
130
241
SAA02
NOMESCO Finland
Basic examination of mouth
5.5
47.6
382
2283
SAA01
NOMESCO Finland
Simple examination of mouth
6.8
46.7
407
2640
SBA00
NOMESCO Finland
Microbiological examinations
17.1
46.3
75
52
D07AC01
ATC
betamethasone; topical
4.2
45.5
267
1152
D07AD01
ATC
clobetasol; topical
4.7
41.4
175
539
K13.78
ICD-10 Finland
Other change in the oral mucosa
15.7
37.9
63
46
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.7
37.3
246
1103
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
14.2
36.3
63
51
L43
ICD-10 Finland
Lichen planus
18.6
36.1
56
34
SXA10
NOMESCO Finland
Epithel biopsy of mouth
32.6
35.9
47
16
E03
ICD-10 Finland
Other hypothyroidism
6.9
33.2
89
156
WX110
NOMESCO Finland
Local anesthesy
3.9
30.8
375
2534
L43.0
ICD-10 Finland
Hypertrophic lichen planus
63.0
30.6
35
6
SFA10
NOMESCO Finland
Fillning on one surface of tooth
3.2
29.1
312
1869
K13.29
ICD-10 Finland
Indefinite leukoplakia
19.4
29.0
44
25
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
3.1
28.3
245
1256
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
3.0
27.5
286
1645
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
3.1
26.7
322
2023
R01AD11
ATC
triamcinolone; nasal
4.7
25.9
97
249
K02.1
ICD-10 Finland
Caries of dentine
2.9
24.7
307
1914
A07AA02
ATC
nystatin; oral
5.4
24.6
79
171
SDA02
NOMESCO Finland
Parodonthologic therapy
2.9
24.4
217
1097
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
2.8
24.3
270
1566
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.8
24.1
246
1351
Z01.2
ICD-10 Finland
Dental examination
2.8
23.8
253
1422
E03.89
ICD-10 Finland
Other specified hypothyroidism
7.1
23.8
60
95
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
6.7
23.4
62
105
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
6.8
22.7
59
97
T86
ICPC
Hypothyroidism/myxoedema
6.6
22.6
60
102
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
2.7
21.7
279
1714
ECA20
NOMESCO Finland
Biopsy of gingiva
16.6
21.4
34
22
EB1AA
NOMESCO Finland
Tooth X-ray examination
2.7
21.3
308
2013
D20
ICPC
Mouth/tongue/lip symptom/complaint
6.5
20.3
54
92
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
2.9
19.9
156
705
KMAK
NOMESCO Finland
NA
2.5
18.7
283
1827
VALMI
NOMESCO Finland
NA
2.7
18.0
153
718
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
2.4
17.1
231
1380
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
2.5
16.2
163
830
-1
NOMESCO Finland
NA
2.4
15.4
183
1012
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
2.5
15.3
157
806
K03.64
ICD-10 Finland
Dental calculus supragingival
2.4
15.0
167
893
D82
ICPC
Teeth/gum disease
2.2
14.0
192
1125
B37.08
ICD-10 Finland
Other candidal stomatitis
18.3
14.0
21
12
WZA90
NOMESCO Finland
Other doctors statement
2.4
13.9
144
734
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.6
13.8
114
514
A01AB09
ATC
miconazole; local oral
3.4
13.5
69
228
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
2.4
13.2
144
749
SAA04
NOMESCO Finland
Special inverstigation of mouth
4.2
13.0
51
134
E0000UV
ATC
NA
2.1
13.0
224
1436
WX290
NOMESCO Finland
Other blockade of nerve
2.1
13.0
212
1326
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.3
12.9
146
775
S02.51
ICD-10 Finland
Fracture of tooth, open
3.1
12.6
74
266
D07AB02
ATC
hydrocortisone butyrate; topical
2.2
12.6
161
903
K05.1
ICD-10 Finland
Chronic gingivitis
3.8
12.2
52
148
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
3.8
11.9
51
146
B37.03
ICD-10 Finland
Chronic atrophic candida infection in the mouth
30.9
11.7
15
5
SDA01
NOMESCO Finland
Simple parodonthologic therapy
2.2
11.6
150
837
R01AD09
ATC
mometasone; nasal
2.0
11.4
248
1713
J02AC01
ATC
fluconazole; systemic
2.0
11.3
250
1733
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
2.2
11.2
149
839
B37.09
ICD-10 Finland
Unspecified candidal stomatitis
14.4
11.1
18
13
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
10.9
160
940
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
5.9
10.9
30
54
K12.10
ICD-10 Finland
Stomatitis NOS
28.8
10.8
14
5
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
2.8
10.6
72
288
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
10.4
238
1654
L43.3
ICD-10 Finland
Subacute (active) lichen planus
33.4
10.4
13
*
A02BC05
ATC
esomeprazole; systemic
1.9
10.4
227
1551
K05.30
ICD-10 Finland
Periodontitis complex
2.7
10.3
76
317
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
10.2
152
895
SFA00
NOMESCO Finland
Small filling
2.5
9.9
82
366
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.0
9.7
324
2550
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
4.2
9.7
36
91
K02.0
ICD-10 Finland
Caries limited to enamel
2.6
9.5
72
305
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.9
9.4
58
218
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
6.3
9.3
24
40
R06AE07
ATC
cetirizine; oral
1.9
9.3
232
1640
K05.10
ICD-10 Finland
Gingivitis (chronic) NOS
2.6
9.2
73
317
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
4.9
9.2
29
62
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
37.5
9.1
11
*
A02BC02
ATC
pantoprazole; systemic
1.9
9.0
321
2548
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
3.8
9.0
37
103
EJ2S1
NOMESCO Finland
Photography of oral mucosa
19.1
9.0
13
7
D07AB08
ATC
desonide; topical
2.7
8.7
62
255
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
28.1
8.5
11
*
K13.20
ICD-10 Finland
Idiopathic leukoplakia
13.1
8.4
14
11
SBB10
NOMESCO Finland
Teeth copy
3.4
8.3
39
121
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
4.7
8.3
27
60
D07AC13
ATC
mometasone; topical
1.9
8.3
154
969
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.0
8.1
123
717
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
17.6
8.1
12
7
UJF32
NOMESCO Finland
Coloscopy
1.9
8.1
138
842
M79.1
ICD-10 Finland
Myalgia
2.3
8.0
74
349
SCA03
NOMESCO Finland
Preventive oral health care, extensive
3.9
8.0
32
87
XQ802
NOMESCO Finland
Epicutan test
3.6
8.0
35
103
N03AX16
ATC
pregabalin; oral
1.9
8.0
136
829
SXA20
NOMESCO Finland
Local application of medicine to mouth
3.2
7.9
40
132
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
2.6
7.8
59
251
SFA40
NOMESCO Finland
Replacement of krone of tooth
2.0
7.7
115
665
R06AX27
ATC
desloratadine; oral
1.9
7.7
141
878
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.4
7.6
64
288
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
4.1
7.6
28
71
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
3.0
7.6
44
159
K05.31
ICD-10 Finland
Periodontitis pronounced
2.6
7.5
57
241
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
2.7
7.4
50
197
L28.0
ICD-10 Finland
Lichen simplex chronicus
7.0
7.4
17
25
N02AX02
ATC
tramadol; systemic, rectal
1.7
7.3
202
1435
B37.01
ICD-10 Finland
Acute athrophy candidal stomatitis
20.4
7.2
10
5
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.3
7.1
66
312
L01
ICPC
Neck symptom/complaint
2.1
7.0
79
406
WYA10
NOMESCO Finland
First aid or other corresponding healthcare contact
2.6
6.9
51
213
N06AA09
ATC
amitriptyline; systemic
2.2
6.9
71
353
A01AC01
ATC
triamcinolone; local oral
5.2
6.9
20
40
-50
ICPC
Medication/prescr/renewal
3.5
6.9
30
89
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.2
6.9
70
343
M01AH05
ATC
etoricoxib; oral
1.7
6.9
283
2244
E000006
ATC
NA
2.5
6.9
53
227
N02BE01
ATC
paracetamol; systemic, rectal
2.2
6.9
403
3594
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.4
6.8
59
269
EBA00
NOMESCO Finland
Extraction of tooth
1.8
6.8
151
998
A02BC03
ATC
lansoprazole; oral
1.8
6.7
156
1044
K60.1
ICD-10 Finland
Chronic anal fissure
5.1
6.7
20
41
PAD
NOMESCO Finland
NA
22.9
6.7
9
*
R03AC02
ATC
salbutamol; inhalant
1.7
6.7
256
1981
K03.1
ICD-10 Finland
Abrasion of teeth
4.5
6.6
22
51
SXC03
NOMESCO Finland
Other oral or dental procedure
10.2
6.6
12
12
E000001
ATC
NA
1.9
6.6
108
644
R01AD12
ATC
fluticasone furoate; nasal
1.7
6.5
150
1000
K03.80
ICD-10 Finland
Irradiated enamel
3.3
6.5
31
99
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
2.2
6.4
66
327
P06
ICPC
Sleep disturbance
2.4
6.4
54
243
K13
ICD-10 Finland
Other diseases of lip and oral mucosa
70.8
6.4
7
*
-34
ICPC
Blood test
4.5
6.4
21
48
SXC05
NOMESCO Finland
Other oral or dental procedure
3.0
6.4
36
126
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.8
6.4
119
739
B37.0
ICD-10 Finland
Candidal stomatitis
8.3
6.4
13
16
TEA00
NOMESCO Finland
Biopsy of lip
8.3
6.4
13
16
G44.2
ICD-10 Finland
Tension-type headache
2.1
6.4
75
393
M03BX02
ATC
tizanidine; oral
1.7
6.3
298
2422
L15
ICPC
Knee symptom/complaint
1.8
6.3
116
719
P01BA02
ATC
hydroxychloroquine; oral
2.3
6.3
58
273
A01AB04
ATC
amphotericin B; local oral
3.0
6.3
34
119
L08
ICPC
Shoulder symptom/complaint
1.9
6.2
104
622
B81
ICPC
Anaemia vit B12/folate deficiency
3.5
6.2
27
80
EMAK
NOMESCO Finland
NA
3.6
6.2
26
75
M25.5
ICD-10 Finland
Pain in joint
1.7
6.2
142
943
M01AE02
ATC
naproxen; oral, rectal
1.6
6.2
266
2107
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
6.1
175
1237
EB1CA
NOMESCO Finland
Tooth X-ray additional picture
2.3
6.1
54
248
A02BC04
ATC
rabeprazole; oral
2.3
6.1
54
250
K29.4
ICD-10 Finland
Chronic atrophic gastritis
5.3
6.1
17
33
R01AD01
ATC
beclometasone; nasal
2.0
6.0
84
470
R06AX22
ATC
ebastine; oral
1.9
6.0
96
565

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: K11_ORAL_LICHEN_HYPOT_THYRO – Oral lichen ruber planus, hypothyreosis or thyroxin

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).